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Conserved domains on  [gi|12408677|ref|NP_002614|]
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prefoldin subunit 4 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Prefoldin_4 cd23165
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic ...
 19-122 8.61e-40

prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


:

Pssm-ID: 467481 [Multi-domain]  Cd Length: 103  Bit Score: 128.82  E-value: 8.61e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12408677  19 DQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDcLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEI 98
Cdd:cd23165   1 DQQKINKFSRLNARLHELKEELKAKKKELENLEDASDELELADDD-EPVPYKIGEVFVHLSLEEAQERLEKAKEELEEEI 79

                        90       100
                ....*....|....*....|....
gi 12408677  99 DALESRVESIQRVLADLKVQLYAK 122
Cdd:cd23165  80 EKLEEEIDEIEEEMKELKVQLYAK 103
 
Name Accession Description Interval E-value
Prefoldin_4 cd23165
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic ...
 19-122 8.61e-40

prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467481 [Multi-domain]  Cd Length: 103  Bit Score: 128.82  E-value: 8.61e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12408677  19 DQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDcLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEI 98
Cdd:cd23165   1 DQQKINKFSRLNARLHELKEELKAKKKELENLEDASDELELADDD-EPVPYKIGEVFVHLSLEEAQERLEKAKEELEEEI 79

                        90       100
                ....*....|....*....|....
gi 12408677  99 DALESRVESIQRVLADLKVQLYAK 122
Cdd:cd23165  80 EKLEEEIDEIEEEMKELKVQLYAK 103
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 23-125 2.68e-17

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 71.49  E-value: 2.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12408677    23 INKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDcLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALE 102
Cdd:pfam01920   1 INKFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDED-TKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTLE 79

                          90       100
                  ....*....|....*....|...
gi 12408677   103 SRVESIQRVLADLKVQLYAKFGS 125
Cdd:pfam01920  80 KQLEKLEKELEELKEELYKKFGQ 102
 
Name Accession Description Interval E-value
Prefoldin_4 cd23165
prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic ...
 19-122 8.61e-40

prefoldin subunit 4; Prefoldin subunit 4 is one of the beta subunits of the eukaryotic prefoldin complex. Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467481 [Multi-domain]  Cd Length: 103  Bit Score: 128.82  E-value: 8.61e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12408677  19 DQQKINKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDcLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEI 98
Cdd:cd23165   1 DQQKINKFSRLNARLHELKEELKAKKKELENLEDASDELELADDD-EPVPYKIGEVFVHLSLEEAQERLEKAKEELEEEI 79

                        90       100
                ....*....|....*....|....
gi 12408677  99 DALESRVESIQRVLADLKVQLYAK 122
Cdd:cd23165  80 EKLEEEIDEIEEEMKELKVQLYAK 103
Prefoldin_2 pfam01920
Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.
 23-125 2.68e-17

Prefoldin subunit; This family includes prefoldin subunits that are not detected by pfam02996.


Pssm-ID: 396482 [Multi-domain]  Cd Length: 102  Bit Score: 71.49  E-value: 2.68e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12408677    23 INKFARNTSRITELKEEIEVKKKQLQNLEDACDDIMLADDDcLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALE 102
Cdd:pfam01920   1 INKFQQLQQQLQLLAQQIKQLETQLKELELALEELELLDED-TKVYKLIGDVLVKQDKEEVKEQLEERKETLEKEIKTLE 79

                          90       100
                  ....*....|....*....|...
gi 12408677   103 SRVESIQRVLADLKVQLYAKFGS 125
Cdd:pfam01920  80 KQLEKLEKELEELKEELYKKFGQ 102
Prefoldin cd00890
prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and ...
 32-110 6.06e-15

prefoldin; Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits; the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes, there are two or more paralogous genes encoding each subunit, adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467470  Cd Length: 79  Bit Score: 65.05  E-value: 6.06e-15
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12408677  32 RITELKEEIEVKKKQLQNLEDACDDIMLADDDCLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALESRVESIQR 110
Cdd:cd00890   1 QVQALSQQIEQLNRQINELEEALDELSNLDKDTEEVYRSVGGVFIEKSKEETKEELEEKLDELQKEIKKLEQQLEAKTK 79
Prefoldin_beta cd00632
Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, ...
 32-110 1.44e-14

Prefoldin beta subunit; Beta subunits of prefoldin, a hexameric molecular chaperone complex, found in both eukaryotes and archaea. Prefoldin binds and stabilizes newly synthesized polypeptides allowing them to fold correctly. The complex contains two alpha and four beta subunits, the two subunits being evolutionarily related. In archaea, there is usually only one gene for each subunit while in eukaryotes there two or more paralogous genes encoding each subunit adding heterogeneity to the structure of the hexamer. The structure of the complex consists of a double beta barrel assembly with six protruding coiled-coils.


Pssm-ID: 467469  Cd Length: 78  Bit Score: 63.90  E-value: 1.44e-14
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 12408677  32 RITELKEEIEVKKKQLQNLEDACDDIMLADDdCLMIPYQIGDVFISHSQEETQEMLEEAKKNLQEEIDALESRVESIQR 110
Cdd:cd00632   1 EVLALKSQKEELERKINEQKVVLDELSNLKK-NRKVYRQQGNIFILASKEETLSELKKTLDHLQKEIKELEQQLKAKEK 78
FAM76 pfam16046
FAM76 protein; This family of proteins is functionally uncharacterized. This family of ...
 33-116 7.23e-03

FAM76 protein; This family of proteins is functionally uncharacterized. This family of proteins is found in eukaryotes. Proteins in this family are typically between 233 and 341 amino acids in length.


Pssm-ID: 464993 [Multi-domain]  Cd Length: 303  Bit Score: 35.15  E-value: 7.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 12408677    33 ITELKEEIEVKKKQLQnledACDDIMLADDDclmipyQIGDVFISHSQEET--QEMLEEAKKNLQEEIDALESRVESIQR 110
Cdd:pfam16046 224 ITQLKEQIASLQKQLA----QKDQQLLEKDK------QITELKAKHFTKERelRNKMKTMEKEHEDKVEQLQIKIRSLLK 293


                  ....*.
gi 12408677   111 VLADLK 116
Cdd:pfam16046 294 EVATLS 299
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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