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Conserved domains on  [gi|11321601|ref|NP_002618|]
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ATP-dependent 6-phosphofructokinase, platelet type isoform 1 [Homo sapiens]

Protein Classification

ATP-dependent 6-phosphofructokinase( domain architecture ID 10092100)

ATP-dependent 6-phosphofructokinase catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committed step of glycolysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 22-783 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


:

Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1449.64  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  22 GAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAF 101
Cdd:cd00764   1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 102 RTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGT 181
Cdd:cd00764  81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 182 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRA 261
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 262 RKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTP 341
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 342 ACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAP 421
Cdd:cd00764 321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAP 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 422 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSIN 501
Cdd:cd00764 401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 502 ALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIE 581
Cdd:cd00764 481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 582 TMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGV 661
Cdd:cd00764 561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 662 FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDF 741
Cdd:cd00764 641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTF 720

                       730       740       750       760
                ....*....|....*....|....*....|....*....|..
gi 11321601 742 EHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWS 783
Cdd:cd00764 721 EHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 22-783 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1449.64  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  22 GAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAF 101
Cdd:cd00764   1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 102 RTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGT 181
Cdd:cd00764  81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 182 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRA 261
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 262 RKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTP 341
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 342 ACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAP 421
Cdd:cd00764 321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAP 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 422 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSIN 501
Cdd:cd00764 401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 502 ALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIE 581
Cdd:cd00764 481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 582 TMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGV 661
Cdd:cd00764 561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 662 FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDF 741
Cdd:cd00764 641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTF 720

                       730       740       750       760
                ....*....|....*....|....*....|....*....|..
gi 11321601 742 EHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWS 783
Cdd:cd00764 721 EHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 25-766 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1315.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601    25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMT 184
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACV 344
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   345 VSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNC---NVAVINVGAP 421
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEAsrlRIAIIHVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   422 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSIN 501
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   502 ALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIE 581
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   582 TMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGV 661
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   662 FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVA-ELKKQTD 740
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSADDTSAVVIGIRGSNVLFTPVKqLLANETD 720

                         730       740
                  ....*....|....*....|....*.
gi 11321601   741 FEHRIPKEQWWLKLRPLMKILAKYKA 766
Cdd:TIGR02478 721 FEHRRPKNQWWLQLRPLVRILAGRDS 746
PFK pfam00365
Phosphofructokinase;
27-330 6.13e-146

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 428.68  E-value: 6.13e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601    27 IGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTREG 106
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   107 RLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSglleelarngqidkeavqkyayLNVVGMVGSIDNDFCGTDMTIG 186
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   187 TDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLsENRARKKRL 266
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKI-KELRKGKRF 213

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 11321601   267 NIIIVAEGAIDTqnkpitsEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAV 330
Cdd:pfam00365 214 SIIVVAEGASDG-------EFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
25-373 9.10e-125

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 376.34  E-value: 9.10e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsglleeLARNGqidkeavqkyayLNVVGMVGSIDNDFCGTDMT 184
Cdd:PRK03202  80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAKR-----------LTEHG------------IPVIGLPGTIDNDIAGTDYT 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKK 264
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGK 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  265 RLNIIIVAEGAIDTQNKpitSEKIKElvvtQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTpacV 344
Cdd:PRK03202 214 KHAIIVVAEGVMPAEEL---AKEIEE----RTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR---M 283

                        330       340       350
                 ....*....|....*....|....*....|
gi 11321601  345 VSLNGNHAVRLPLMECV-QMTQDVQKAMDE 373
Cdd:PRK03202 284 VGIQNNKIVHVPIEEAVeNMKHPFDKDLYE 313
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 25-382 7.95e-122

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 369.40  E-value: 7.95e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:COG0205   2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSglleelarngqidkeavqkyayLNVVGMVGSIDNDFCGTDMT 184
Cdd:COG0205  80 EGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYT 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKK 264
Cdd:COG0205 138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGK 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 265 RLNIIIVAEGAIDTQNKPI---------------TSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEA 329
Cdd:COG0205 215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAA 294

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 11321601 330 VIALLEatpDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDerRFQDAVRL 382
Cdd:COG0205 295 VELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPVDPDSP--LIQLAREL 342
 
Name Accession Description Interval E-value
Eukaryotic_PFK cd00764
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 22-783 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include eukaryotic ATP-dependent phosphofructokinases. These have evolved from the bacterial PFKs by gene duplication and fusion events and exhibit complex allosteric behavior.


Pssm-ID: 238389 [Multi-domain]  Cd Length: 762  Bit Score: 1449.64  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  22 GAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAF 101
Cdd:cd00764   1 GAGKAIAVLTSGGDAQGMNAAVRAVVRMGIYVGAKVFFVYEGYEGLVKGGDYIKQAEWESVSNWLQEGGTIIGSARCKEF 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 102 RTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGT 181
Cdd:cd00764  81 REREGRLQAAYNLIQRGITNLCVIGGDGSLTGADLFRSEWPSLLEELVKDGKITEEEVAKYQHLNIVGMVGSIDNDFCGT 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 182 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRA 261
Cdd:cd00764 161 DMTIGTDSALHRICEVVDAITTTAQSHQRTFVLEVMGRHCGYLALVSGLATGADWIFIPERPPEDGWEDQMCRRLSEHRS 240

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 262 RKKRLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTP 341
Cdd:cd00764 241 RGKRLNIIIVAEGAIDDQLKPITSEDVKDLVVERLGLDTRVTTLGHVQRGGTPSAFDRILASLMGVEAVMALLEATPDTP 320

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 342 ACVVSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNCNVAVINVGAP 421
Cdd:cd00764 321 ACVVSLNGNKAVRLPLMECVQLTKDVQKAMDEKRFDEAAALRGKSFDKNWNLYKLLAIELPQPLPEKTNLNIAIVNVGAP 400

                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 422 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSIN 501
Cdd:cd00764 401 AAGMNAAVRSAVRYGLAHGHRPYAIYDGFEGLAKGQIVELGWIDVGGWTGRGGSELGTKRTLPKKDLETIAYNFQKYGID 480

                       490       500       510       520       530       540       550       560
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 502 ALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIE 581
Cdd:cd00764 481 GLIIVGGFEAYKGLLQLREAREQYEEFCIPMVLIPATVSNNVPGTDFSLGSDTALNALMKYCDRIKQSASGTKRRVFIVE 560

                       570       580       590       600       610       620       630       640
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 582 TMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGV 661
Cdd:cd00764 561 TMGGYCGYLATMTGLAVGADAAYVFEEPFNIRDLQENVEHLTEKMKTTIGRGLVLRNEKCNENYTTVFTYELYSEEGKGV 640

                       650       660       670       680       690       700       710       720
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 662 FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVAELKKQTDF 741
Cdd:cd00764 641 FDCRTNVLGHVQQGGAPSPFDRNFGTKFAVKAMKWIEQKLKENYAAGNEFANDPDFNCVNGVKKYAVLFEPVEELKQTTF 720

                       730       740       750       760
                ....*....|....*....|....*....|....*....|..
gi 11321601 742 EHRIPKEQWWLKLRPLMKILAKYKASYDVSDSGQLEHVQPWS 783
Cdd:cd00764 721 EHRIPKEQWWLSLRPLLKILAKYKISADISDHGQLEHVTRGQ 762
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 25-766 0e+00

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 1315.80  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601    25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:TIGR02478   1 KRIAVLTSGGDAQGMNAAVRAVVRMAIYVGCRVYAIREGYQGLVDGGDNIEEAQWEDVRGILSLGGTIIGTARCKEFRER 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGLLEELARNGQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMT 184
Cdd:TIGR02478  81 PGRLKAARNLVSNGIDALVVIGGDGSLTGADLFREEWPSLLEELVDTGKITAEQAEEHRHLTIVGLVGSIDNDMCGTDMT 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264
Cdd:TIGR02478 161 IGADSALHRICEAIDAISSTAQSHQRAFVVEVMGRHCGYLALMAAIATGADYVFIPERPPEEGWEDQLCHKLKRNRKAGK 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACV 344
Cdd:TIGR02478 241 RKTIVIVAEGAIDRDLNPITSEDVKDVLVERLGLDTRITVLGHVQRGGAPSAFDRILATRQGVEAVLAVLESTPETPSPV 320

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   345 VSLNGNHAVRLPLMECVQMTQDVQKAMDERRFQDAVRLRGRSFAGNLNTYKRLAIKLPDDQIPKTNC---NVAVINVGAP 421
Cdd:TIGR02478 321 ISLRGNKIVRKPLVEAVAQTKTVAKAIEEKDFDEAMRLRGREFAENLETFLFLSIPDDDKKLVPSEAsrlRIAIIHVGAP 400

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   422 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLEEIATQMRTHSIN 501
Cdd:TIGR02478 401 AGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHDVRELTWSDVEGWVGEGGSELGTNRSLPGDDLGTIAYYFQQHKID 480

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   502 ALLIIGGFEAYLGLLELSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKRRVFIIE 581
Cdd:TIGR02478 481 GLIIIGGFEAFEALYQLDAAREKYPAFRIPMVVIPATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASASKRRVFVVE 560

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   582 TMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIQRGLVLRNESCSENYTTDFIYQLYSEEGKGV 661
Cdd:TIGR02478 561 TMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQEDIEHLKETFAEGRAGKLILRNEKASKVYTTDFIARIISEEGKGR 640

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   662 FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKLKEARGRGKKFTTDDSICVLGISKRNVIFQPVA-ELKKQTD 740
Cdd:TIGR02478 641 FDARTAVLGHMQQGGSPSPFDRVRATRLAIRAVDFIEEKIKANKHADKLSADDTSAVVIGIRGSNVLFTPVKqLLANETD 720

                         730       740
                  ....*....|....*....|....*.
gi 11321601   741 FEHRIPKEQWWLKLRPLMKILAKYKA 766
Cdd:TIGR02478 721 FEHRRPKNQWWLQLRPLVRILAGRDS 746
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 25-392 0e+00

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 546.90  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:cd00363   1 KKIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEG--DIKELDWESVSDIINRGGTIIGSARCKEFRTE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSGlleelarngqidkeavqKYAYLNVVGMVGSIDNDFCGTDMT 184
Cdd:cd00363  79 EGRAKAAENLKKHGIDALVVIGGDGSYTGADLLTEEWPS-----------------KYQGFNVIGLPGTIDNDIKGTDYT 141

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVKLSENRARKK 264
Cdd:cd00363 142 IGFDTALKTIVEAIDRIRDTASSHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEWEEEMVDVIKKRRERGK 221

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 265 RLNIIIVAEGAIDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTPACV 344
Cdd:cd00363 222 RHGIVIVAEGAIDFIPKPITEKLLAKLVEERLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEGTGGTPVGI 301

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*...
gi 11321601 345 VSLNGNHAVRLPLMECVQMTQDVQkamderrfqdaVRLRGRSFAGNLN 392
Cdd:cd00363 302 QNLNENQVVRHPLTEAVNMTKRVG-----------VDLEGRPFKKFAK 338
PFK pfam00365
Phosphofructokinase;
27-330 6.13e-146

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 428.68  E-value: 6.13e-146
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601    27 IGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTREG 106
Cdd:pfam00365   2 IGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEG--DIDELTWRDVSGILNRGGTILGTSRSKPFKTEEG 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   107 RLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSglleelarngqidkeavqkyayLNVVGMVGSIDNDFCGTDMTIG 186
Cdd:pfam00365  80 REKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG----------------------IPVVGIPKTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   187 TDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLsENRARKKRL 266
Cdd:pfam00365 138 FDTALNTIVEAIDRIRDTASSHNRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFD---IEELCEKI-KELRKGKRF 213

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 11321601   267 NIIIVAEGAIDTqnkpitsEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAV 330
Cdd:pfam00365 214 SIIVVAEGASDG-------EFLAKLIEEGTGIETRVTVLGHVQRGGTPSAFDRILATRLGVKAV 270
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
25-373 9.10e-125

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 376.34  E-value: 9.10e-125
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:PRK03202   2 KRIGVLTSGGDAPGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEG--DIVKLDLKSVSDIINRGGTILGSARFPEFKDE 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsglleeLARNGqidkeavqkyayLNVVGMVGSIDNDFCGTDMT 184
Cdd:PRK03202  80 EGRAKAIENLKKLGIDALVVIGGDGSYMGAKR-----------LTEHG------------IPVIGLPGTIDNDIAGTDYT 136

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKK 264
Cdd:PRK03202 137 IGFDTALNTAVEAIDRLRDTASSHERVFIVEVMGRHAGDLALHAGIAGGAEVILIPEVPFD---IEELCAKIKKGRERGK 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  265 RLNIIIVAEGAIDTQNKpitSEKIKElvvtQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEATPDTpacV 344
Cdd:PRK03202 214 KHAIIVVAEGVMPAEEL---AKEIEE----RTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVELLLEGKGGR---M 283

                        330       340       350
                 ....*....|....*....|....*....|
gi 11321601  345 VSLNGNHAVRLPLMECV-QMTQDVQKAMDE 373
Cdd:PRK03202 284 VGIQNNKIVHVPIEEAVeNMKHPFDKDLYE 313
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 25-382 7.95e-122

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 369.40  E-value: 7.95e-122
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:COG0205   2 KRIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEG--DIIDLTREDVSGILQRGGTILGSSRSKPFKTE 79

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEWSglleelarngqidkeavqkyayLNVVGMVGSIDNDFCGTDMT 184
Cdd:COG0205  80 EGREKALENLKKLGIDALVVIGGDGSLDGAAKLAEEYG----------------------IPVVGIPKTIDNDLPGTDYT 137

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKK 264
Cdd:COG0205 138 IGFDTAVNTAAEAIDRLRDTAASHERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFD---LDKLLEKLKERRKRGK 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 265 RLNIIIVAEGAIDTQNKPI---------------TSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEA 329
Cdd:COG0205 215 GYSIIVVAEGAGDEDGEAVleadtdafghvrlggIGEYLAKEIEERTGIETRVTVLGHLQRGGSPSAFDRVLASRLGAAA 294

                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|...
gi 11321601 330 VIALLEatpDTPACVVSLNGNHAVRLPLMECVQMTQDVQKAMDerRFQDAVRL 382
Cdd:COG0205 295 VELLLE---GKTGVMVGIRRGEIVLVPLEEVANKEKPVDPDSP--LIQLAREL 342
PFKA_ATP TIGR02482
6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate ...
 27-359 2.38e-110

6-phosphofructokinase; 6-phosphofructokinase (EC 2.7.1.11) catalyzes the addition of phosphate from ATP to fructose 6-phosphate to give fructose 1,6-bisphosphate. This represents a key control step in glycolysis. This model hits bacterial ATP-dependent 6-phosphofructokinases which lack a beta-hairpin loop present in TIGR02483 family members. TIGR02483 contains members that are ATP-dependent as well as members that are pyrophosphate-dependent. TIGR02477 represents the pyrophosphate-dependent phosphofructokinase, diphosphate--fructose-6-phosphate 1-phosphotransferase (EC 2.7.1.90). [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 213713 [Multi-domain]  Cd Length: 301  Bit Score: 338.17  E-value: 2.38e-110
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601    27 IGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTREG 106
Cdd:TIGR02482   2 IGILTSGGDAPGMNAAIRAVVRTAIYHGFEVYGIRRGYKGLING--KIEPLESKNVSGIIHRGGTILGTARCPEFKTEEV 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   107 RLKAACNLLQRGITNLCVIGGDGSLTGANLFRKEwsglleelarnGQIdkeavqkyaylNVVGMVGSIDNDFCGTDMTIG 186
Cdd:TIGR02482  80 REKAVENLKKLGIEGLVVIGGDGSYTGAQKLYEE-----------GGI-----------PVIGLPGTIDNDIPGTDYTIG 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   187 TDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKKRL 266
Cdd:TIGR02482 138 FDTALNTIIDAVDKIRDTATSHERAFVIEVMGRHAGDLALYAGIATGAEIIIIPEFDYD---IDELIQRLKEQHEAGKKH 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   267 NIIIVAEGAIDTQNKPItSEKIKELVvtqlGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEatpDTPACVVS 346
Cdd:TIGR02482 215 SIIIVAEGNIVGSAKEV-AKKIEEKT----GIETRVTVLGHTQRGGSPSAFDRVLASRLGAKAVELLLE---GKGGVMIG 286

                         330
                  ....*....|...
gi 11321601   347 LNGNHAVRLPLME 359
Cdd:TIGR02482 287 IQNNKIVTHPIEE 299
PFK pfam00365
Phosphofructokinase;
412-695 1.02e-104

Phosphofructokinase;


Pssm-ID: 459783 [Multi-domain]  Cd Length: 271  Bit Score: 322.37  E-value: 1.02e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   412 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGK---YL 488
Cdd:pfam00365   1 RIGILTSGGDAPGMNAAIRAVVRTAIYRGHEVYGIRNGYEGLVEGDIDELTWRDVSGILNRGGTILGTSRSKPFKteeGR 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   489 EEIATQMRTHSINALLIIGGFEAYLGLLELSAAREkheefcVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQ 568
Cdd:pfam00365  81 EKIAENLKKLGIDALVVIGGDGSLTGANKLSEERG------IPVVGIPKTIDNDIPGTDYTIGFDTALNTIVEAIDRIRD 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   569 SASGTkRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKTTIqrglVLRNESCSenyTTD 648
Cdd:pfam00365 155 TASSH-NRVFVVEVMGRHCGWLALMAGLAGGADAILIPEIPFDIEELCEKIKELRKGKRFSI----IVVAEGAS---DGE 226

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 11321601   649 FIYQLYsEEGKGvFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAME 695
Cdd:pfam00365 227 FLAKLI-EEGTG-IETRVTVLGHVQRGGTPSAFDRILATRLGVKAVE 271
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 25-371 9.40e-99

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 308.57  E-value: 9.40e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGgsNIAEADWESVSSILQVGGTIIGSARCQAFRTR 104
Cdd:cd00763   1 KRIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAG--DIVPLDRYSVSDIINRGGTFLGSARFPEFKDE 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsglleeLARNGqidkeavqkyayLNVVGMVGSIDNDFCGTDMT 184
Cdd:cd00763  79 EGQAKAIEQLKKHGIDALVVIGGDGSYMGAMR-----------LTEHG------------FPCVGLPGTIDNDIPGTDYT 135

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKK 264
Cdd:cd00763 136 IGFDTALNTVVEAIDRIRDTSSSHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFD---REEVANRIKAGIERGK 212

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 265 RLNIIIVAEGAIDtqnkpitSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVEAVIALLEAtpdTPACV 344
Cdd:cd00763 213 KHAIVVVAEGVYD-------VDELAKEIEEATGFETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLAG---KGGLA 282

                       330       340
                ....*....|....*....|....*..
gi 11321601 345 VSLNGNHAVRLPLMECVQMTQDVQKAM 371
Cdd:cd00763 283 VGIQNEQLVHHDIIDAIENMKPFKKDW 309
PFK_mixed TIGR02483
phosphofructokinase; Members of this family that are characterized, save one, are ...
 27-361 5.69e-81

phosphofructokinase; Members of this family that are characterized, save one, are phosphofructokinases dependent on pyrophosphate (EC 2.7.1.90) rather than ATP (EC 2.7.1.11). The exception is one of three phosphofructokinases from Streptomyces coelicolor. Family members are both bacterial and archaeal. [Energy metabolism, Glycolysis/gluconeogenesis]


Pssm-ID: 274155 [Multi-domain]  Cd Length: 324  Bit Score: 262.24  E-value: 5.69e-81
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601    27 IGVLTSGGDAQGMNAAVRAVVRMGIYV-GAKVYFIYEGYQGMVDGGSnIAEADWESVSSILQVGGTIIGSARCQAFRT-R 104
Cdd:TIGR02483   2 IGVLTGGGDCPGLNAVIRGVVRRAIAEyGWEVIGIRDGWRGLLEGDT-VPLLDLEDVRGILPRGGTILGSSRTNPFKYeE 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANlfrkewsglleELARNGqidkeavqkyayLNVVGMVGSIDNDFCGTDMT 184
Cdd:TIGR02483  81 DGDDKIVANLKELGLDALIAIGGDGTLGIAR-----------RLADKG------------LPVVGVPKTIDNDLEATDYT 137

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   185 IGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEegwEEQMCVKLSENRARKK 264
Cdd:TIGR02483 138 FGFDTAVEIATEALDRLHTTAESHHRVMVVEVMGRHAGWIALHSGIAGGADVILIPEIPFD---IDSVCEKVRERFARGK 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   265 RLNIIIVAEGA--------IDTQNKPI--------TSEKIKELVVTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVE 328
Cdd:TIGR02483 215 RFAIVVVAEGAkpkggemvVQEGVKDAfghvrlggIGNWLAEEIERRTGIETRATVLGHLQRGGSPSAFDRVLATRFGVA 294

                         330       340       350
                  ....*....|....*....|....*....|...
gi 11321601   329 AVIALLEATPDTpacVVSLNGNHAVRLPLMECV 361
Cdd:TIGR02483 295 AVDLVHEGQFGH---MVALRGTDIVYVPIAEAV 324
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
22-330 1.84e-59

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 205.69  E-value: 1.84e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   22 GAGKAIGVLTSGGDAQGMNAAVRAVVR--MGIYvGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQ 99
Cdd:PRK14071   2 GEKKRIGILTSGGDCAGLNAVIRAVVHraRGTY-GWEVIGIRDATQGLMARPPQYIELDLDQVDDLLRMGGTILGTTNKG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  100 ---AFRTREGRLKAACN-----LLQRGITNLCVIGGDGSLtganlfrkewsGLLEELARNGQIdkeavqkyaylNVVGMV 171
Cdd:PRK14071  81 dpfAFPMPDGSLRDRSQeiidgYHSLGLDALIGIGGDGSL-----------AILRRLAQQGGI-----------NLVGIP 138

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  172 GSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPpeegWE-E 250
Cdd:PRK14071 139 KTIDNDVGATEVSIGFDTAVNIATEALDRLHFTAASHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIP----YTlE 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  251 QMCVKLSENRARKKRLNIIIVAEGAIDTQNKPITSEK-------------IKELVVTQLGYDTRVTILGHVQRGGTPSAF 317
Cdd:PRK14071 215 NVCKKIRERQEEGKNFCLVVVSEAVRTEEGEQVTKTQalgedryggigqyLAEQIAERTGAETRVTVLGHIQRGGIPSPR 294

                        330
                 ....*....|...
gi 11321601  318 DRILASRMGVEAV 330
Cdd:PRK14071 295 DRLLASAFGVAAV 307
PfkA COG0205
6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part ...
 412-697 1.00e-51

6-phosphofructokinase [Carbohydrate transport and metabolism]; 6-phosphofructokinase is part of the Pathway/BioSystem: Glycolysis


Pssm-ID: 439975 [Multi-domain]  Cd Length: 344  Bit Score: 183.74  E-value: 1.00e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 412 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGK---YL 488
Cdd:COG0205   3 RIGILTSGGDAPGLNAAIRAVVRTAIKYGIEVYGIRDGYEGLLEGDIIDLTREDVSGILQRGGTILGSSRSKPFKteeGR 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 489 EEIATQMRTHSINALLIIGGfeaylgllE--LSAAREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRI 566
Cdd:COG0205  83 EKALENLKKLGIDALVVIGG--------DgsLDGAAKLAEEYGIPVVGIPKTIDNDLPGTDYTIGFDTAVNTAAEAIDRL 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 567 KQSASGTkRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLqsnVEHLTEKMKTTIQRGLVL--------RN 638
Cdd:COG0205 155 RDTAASH-ERVFVVEVMGRHAGWLALAAGLAGGADLILIPEVPFDLDKL---LEKLKERRKRGKGYSIIVvaegagdeDG 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 11321601 639 ESCSENYTTDFIYQLYSEEGKGV---------FDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWI 697
Cdd:COG0205 231 EAVLEADTDAFGHVRLGGIGEYLakeieertgIETRVTVLGHLQRGGSPSAFDRVLASRLGAAAVELL 298
6PF1K_euk TIGR02478
6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one ...
 15-349 1.87e-51

6-phosphofructokinase, eukaryotic type; Members of this family are eukaryotic (with one exception) ATP-dependent 6-phosphofructokinases (EC 2.7.1.11) in which two tandem copies of the phosphofructokinase are found. Members are found, often including several isozymes, in animals and fungi and in the bacterium Propionibacterium acnes KPA171202 (a human skin commensal).


Pssm-ID: 274152 [Multi-domain]  Cd Length: 746  Bit Score: 192.17  E-value: 1.87e-51
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601    15 KFLEHLSGAGKAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIYEGYQGMVDGGsnIAEADWESVSSILQVGGTIIG 94
Cdd:TIGR02478 380 KKLVPSEASRLRIAIIHVGAPAGGMNAATRSAVRYALARGHTVIAIHNGFSGLARHD--VRELTWSDVEGWVGEGGSELG 457

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601    95 SARcqafRTREGRLKA-ACNLLQRGITNLCVIGGDGSLTGANlfrkewsglleelarngQIDKeAVQKYAYLNV--VGMV 171
Cdd:TIGR02478 458 TNR----SLPGDDLGTiAYYFQQHKIDGLIIIGGFEAFEALY-----------------QLDA-AREKYPAFRIpmVVIP 515

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   172 GSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQ-SHQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEE 250
Cdd:TIGR02478 516 ATISNNVPGTEYSLGSDTALNEITEYCDNIKQSASaSKRRVFVVETMGGYSGYLATMAGLATGADAAYIPEEGISLKDLQ 595

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   251 QMCVKLSENRARKKRLNIIIVAEGAIDTqnkpITSEKIKELV--VTQLGYDTRVTILGHVQRGGTPSAFDRILASRMGVE 328
Cdd:TIGR02478 596 EDIEHLKETFAEGRAGKLILRNEKASKV----YTTDFIARIIseEGKGRFDARTAVLGHMQQGGSPSPFDRVRATRLAIR 671

                         330       340       350
                  ....*....|....*....|....*....|..
gi 11321601   329 AVIALLEATP-----------DTPACVVSLNG 349
Cdd:TIGR02478 672 AVDFIEEKIKankhadklsadDTSAVVIGIRG 703
Bacterial_PFK cd00763
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 413-754 4.97e-51

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent phosphofructokinases. These are allosrterically regulated homotetramers; the subunits are of about 320 amino acids.


Pssm-ID: 238388 [Multi-domain]  Cd Length: 317  Bit Score: 181.07  E-value: 4.97e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 413 VAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvLPGKYLEEI- 491
Cdd:cd00763   3 IGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIRDGYAGLIAGDIVPLDRYSVSDIINRGGTFLGSAR-FPEFKDEEGq 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 492 ---ATQMRTHSINALLIIGGFEAYLGLLELSaarekheEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQ 568
Cdd:cd00763  82 akaIEQLKKHGIDALVVIGGDGSYMGAMRLT-------EHGFPCVGLPGTIDNDIPGTDYTIGFDTALNTVVEAIDRIRD 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 569 SASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKttiQRGLVLRNESCsenYTTD 648
Cdd:cd00763 155 TSS-SHQRISVVEVMGRHCGDIALAAGIAGGAEFIVIPEAEFDREEVANRIKAGIERGK---KHAIVVVAEGV---YDVD 227

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 649 FIYQLYSEEGKgvFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAklkearGRGkkfttddSICVlGISKRNVI 728
Cdd:cd00763 228 ELAKEIEEATG--FETRATVLGHIQRGGSPTAFDRILASRMGAYAVELLLA------GKG-------GLAV-GIQNEQLV 291

                       330       340
                ....*....|....*....|....*.
gi 11321601 729 FQPVAELkkqtdFEHRIPKEQWWLKL 754
Cdd:cd00763 292 HHDIIDA-----IENMKPFKKDWLAL 312
PFK cd00363
Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of ...
 412-735 5.16e-50

Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases. Some members evolved by gene duplication and thus have a large C-terminal/N-terminal extension comprising a second PFK domain. Generally, ATP-PFKs are allosteric homotetramers, and PPi-PFKs are dimeric and nonallosteric except for plant PPi-PFKs which are allosteric heterotetramers.


Pssm-ID: 238216 [Multi-domain]  Cd Length: 338  Bit Score: 179.03  E-value: 5.16e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 412 NVAVINVGAPAAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvLPGKYLEEI 491
Cdd:cd00363   2 KIGVLTSGGDAPGMNAAIRGVVRSAIAEGLEVYGIYEGYAGLVEGDIKELDWESVSDIINRGGTIIGSAR-CKEFRTEEG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 492 ----ATQMRTHSINALLIIGGFEAYLGLLEL-SAAREKHEEFcvPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRI 566
Cdd:cd00363  81 rakaAENLKKHGIDALVVIGGDGSYTGADLLtEEWPSKYQGF--NVIGLPGTIDNDIKGTDYTIGFDTALKTIVEAIDRI 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 567 KQSASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDlqsnVEHLTEKMKTTIQRG----LVLRNEScs 642
Cdd:cd00363 159 RDTAS-SHQRTFVVEVMGRHCGDIALEAGLATGADIIFIPEEPAADEW----EEEMVDVIKKRRERGkrhgIVIVAEG-- 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601 643 enyTTDFIYQLYSEEG-------KGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITAKlkeargrgkkfTTDD 715
Cdd:cd00363 232 ---AIDFIPKPITEKLlaklveeRLGFDTRATVLGHVQRGGTPTAFDRILASRLGAEAVELLLEG-----------TGGT 297

                       330       340
                ....*....|....*....|
gi 11321601 716 SICVLGISKRNVIFQPVAEL 735
Cdd:cd00363 298 PVGIQNLNENQVVRHPLTEA 317
PRK03202 PRK03202
ATP-dependent 6-phosphofructokinase;
422-695 1.77e-49

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235111 [Multi-domain]  Cd Length: 320  Bit Score: 176.81  E-value: 1.77e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  422 AAGMNAAVRSAVRVGIADGHRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRVLPGKYLE---EIATQMRTH 498
Cdd:PRK03202  13 APGMNAAIRAVVRTAISEGLEVYGIYDGYAGLLEGDIVKLDLKSVSDIINRGGTILGSARFPEFKDEEgraKAIENLKKL 92

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  499 SINALLIIGGFEAYLGLLELSaarekheEFCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASgTKRRVF 578
Cdd:PRK03202  93 GIDALVVIGGDGSYMGAKRLT-------EHGIPVIGLPGTIDNDIAGTDYTIGFDTALNTAVEAIDRLRDTAS-SHERVF 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  579 IIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIRDLQSNVEHLTEKMKttiQRGLVLRNES-CSENYTTDFIyqlyseE 657
Cdd:PRK03202 165 IVEVMGRHAGDLALHAGIAGGAEVILIPEVPFDIEELCAKIKKGRERGK---KHAIIVVAEGvMPAEELAKEI------E 235

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 11321601  658 GKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAME 695
Cdd:PRK03202 236 ERTGLETRVTVLGHIQRGGSPTAFDRVLASRMGAHAVE 273
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 27-279 2.64e-27

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 115.91  E-value: 2.64e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   27 IGVLTSGGDAQGMNAAVRAVVRMGIYV-GAK-VYFIYEGYQGMVDGGSniAEADWESVSSILQVGGTIIGSARcqafrTR 104
Cdd:PTZ00286  90 AGIVTCGGLCPGLNVVIRELVMNLINNyGVKtIYGAKYGYKGLYKEDW--IKLDPKDVKTIHRLGGTILGSSR-----GG 162

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  105 EGRLKAACNLLQRGITNLCVIGGDGSLTGANlfrkewsglleelarngQIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMT 184
Cdd:PTZ00286 163 FDPKVMVDTLIRHGINILFTLGGDGTHRGAL-----------------AIYKELRRRKLNISVVGIPKTIDNDIPIIDES 225

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  185 IGTDSALHRIIEVVDAIMTTAQSHQRTF-VLEVMGRHCGYLALVSALACG-ADWVFLPESPpeegWEEQMCVKLSENRAR 262
Cdd:PTZ00286 226 FGFQTAVEEAQNAIRAAYVEAKSAKNGVgIVKLMGRDSGFIALHASVASAdVNVCLIPEFD----IPLEGVLEYIEQRLQ 301

                        250
                 ....*....|....*..
gi 11321601  263 KKRLNIIIVAEGAIDTQ 279
Cdd:PTZ00286 302 KKGHCVIVVAEGAGQSL 318
PRK06830 PRK06830
ATP-dependent 6-phosphofructokinase;
28-275 7.62e-20

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 235869  Cd Length: 443  Bit Score: 93.01  E-value: 7.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   28 GVLTSGGDAQGMNAAVRAVVR--MGIYVGAKVYFIYEGYQGMV-DGGSNIAEADWESVSSILQVGGTIIGSARcqafrtr 104
Cdd:PRK06830  84 AIVTCGGLCPGLNDVIRAIVLelHHHYGVRRILGIRYGYQGLIpRYGHDPVELTPEVVADIHEFGGTILGSSR------- 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  105 eGRLKAAC---NLLQRGITNLCVIGGDGSLTGAnlfrkewSGLLEELARNGqidkeavQKYAylnVVGMVGSIDNDFCGT 181
Cdd:PRK06830 157 -GPQDPEEivdTLERMNINILFVIGGDGTLRGA-------SAIAEEIERRG-------LKIS---VIGIPKTIDNDINFI 218

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  182 DMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVL-EVMGRHCGYLALVSALACG-ADWVFLPESPPEEGWEEQMCVKLsEN 259
Cdd:PRK06830 219 QKSFGFETAVEKATEAIRCAHVEANGAPNGIGLvKLMGRHSGFIAAYAALASKdVNFVLIPEVPFDLEGPNGLLAAL-EK 297

                        250
                 ....*....|....*.
gi 11321601  260 RARKKRLNIIIVAEGA 275
Cdd:PRK06830 298 RLAERGHAVIVVAEGA 313
PRK14071 PRK14071
ATP-dependent 6-phosphofructokinase;
413-699 2.78e-18

ATP-dependent 6-phosphofructokinase;


Pssm-ID: 184487 [Multi-domain]  Cd Length: 360  Bit Score: 87.43  E-value: 2.78e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  413 VAVINVGAPAAGMNAAVRSAVRVGIAD-GHRMLAIYDGFDGFAKG--QIKEIGWTDVGGWTGQGGSILGT-KRVLPGKY- 487
Cdd:PRK14071   7 IGILTSGGDCAGLNAVIRAVVHRARGTyGWEVIGIRDATQGLMARppQYIELDLDQVDDLLRMGGTILGTtNKGDPFAFp 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  488 ---------LEEIATQMRTHSINALLIIGGfEAYLGLLelsaaREKHEEFCVPMVMVPATVSNNVPGSDFSIGADTALNT 558
Cdd:PRK14071  87 mpdgslrdrSQEIIDGYHSLGLDALIGIGG-DGSLAIL-----RRLAQQGGINLVGIPKTIDNDVGATEVSIGFDTAVNI 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  559 ITDTCDRIKQSASgTKRRVFIIETMGGYCGYLANMGGLAAGADAAYIFEEPFDIrdlqsnvEHLTEKMKTTIQRG----L 634
Cdd:PRK14071 161 ATEALDRLHFTAA-SHNRVMILEVMGRDAGHIALAAGIAGGADVILIPEIPYTL-------ENVCKKIRERQEEGknfcL 232

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  635 VLRNESC----SENYTTDF---------IYQLYSEE--GKGVFDCRKNVLGHMQQGGAPSPFDRNFGTKISARAMEWITA 699
Cdd:PRK14071 233 VVVSEAVrteeGEQVTKTQalgedryggIGQYLAEQiaERTGAETRVTVLGHIQRGGIPSPRDRLLASAFGVAAVDLIAQ 312
PLN02564 PLN02564
6-phosphofructokinase
 29-275 3.99e-16

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 82.10  E-value: 3.99e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   29 VLTSGGDAQGMNAAVRAVVrMGI---YVGAKVYFIYEGYQGMVdgGSNIAEADWESVSSILQVGGTIIGSARcqafrTRE 105
Cdd:PLN02564  92 IVTCGGLCPGLNTVIREIV-CGLsymYGVTRILGIDGGYRGFY--SRNTIPLTPKVVNDIHKRGGTILGTSR-----GGH 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  106 GRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsgLLEELARNGqidkeavQKYAylnVVGMVGSIDNDFCGTDMTI 185
Cdd:PLN02564 164 DTSKIVDSIQDRGINQVYIIGGDGTQKGASV-------IYEEIRRRG-------LKVA---VAGIPKTIDNDIPVIDKSF 226

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  186 GTDSALHRIIEVVDAIMTTAQS-HQRTFVLEVMGRHCGYLALVSALAC-GADWVFLPESP----PEEGWEEQMCVKLSEN 259
Cdd:PLN02564 227 GFDTAVEEAQRAINAAHVEAESvENGIGLVKLMGRYSGFIAMYATLASrDVDCCLIPESPfyleGKGGLFEFIEKRLKEN 306

                        250
                 ....*....|....*.
gi 11321601  260 RARkkrlnIIIVAEGA 275
Cdd:PLN02564 307 GHM-----VIVVAEGA 317
PRK14072 PRK14072
diphosphate--fructose-6-phosphate 1-phosphotransferase;
157-335 3.54e-15

diphosphate--fructose-6-phosphate 1-phosphotransferase;


Pssm-ID: 237600 [Multi-domain]  Cd Length: 416  Bit Score: 78.36  E-value: 3.54e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  157 EAVQKYAY-LNVVGMVGSIDNDFCGTDMTIGTDSALHRIIEVV-----D-AIMTTaqsHQRTFVLEVMGRHCGYLALVSA 229
Cdd:PRK14072 124 QLAKKMGYpIRCIGIPKTIDNDLPGTDHCPGFGSAAKYIATSVleaalDvAAMAN---TSKVFILEVMGRHAGWLAAAAA 200

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  230 LAC-----GADWVFLPESPPEegwEEQMCVKLSENRARKKRLnIIIVAEGAIDTQNKPITSEK----------------- 287
Cdd:PRK14072 201 LAKqnpddAPHLIYLPERPFD---EEKFLADVRAIVKRYGYC-VVVVSEGIRDADGKFIAEAGlaedafghaqlggvapv 276

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 11321601  288 IKELVVTQLGYDTRVTILGHVQR--GGTPSAFDRILASRMGVEAVIALLE 335
Cdd:PRK14072 277 LANLIKEKLGKKVHWAVLDYLQRaaRHIASKTDVEEAYAVGKAAVEYALA 326
PLN02884 PLN02884
6-phosphofructokinase
 28-367 4.99e-15

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 77.93  E-value: 4.99e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   28 GVLTSGGDAQGMNAAVRAVV-RMGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSILQVGGTIIGSARCQAfRTREg 106
Cdd:PLN02884  57 AIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRKVVQNIHLSGGSLLGVSRGGA-KTSD- 134

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  107 rlkAACNLLQRGITNLCVIGGDGSLTGANLfrkewsglleelarngqIDKEAVQKYAYLNVVGMVGSIDNDFCGTDMTIG 186
Cdd:PLN02884 135 ---IVDSIEARGINMLFVLGGNGTHAGANA-----------------IHNECRKRKMKVSVVGVPKTIDNDILLMDKTFG 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  187 TDSALHRIIEVVDAIMTTAQSHQRTF-VLEVMGRHCGYLALVSALACG-ADWVFLPESPPEEGWEEQMCVKLsENRARKK 264
Cdd:PLN02884 195 FDTAVEEAQRAINSAYIEAHSAYHGIgLVKLMGRSSGFIAMHASLASGqVDICLIPEVPFTLDGPNGVLRHL-EHLIETK 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  265 RLNIIIVAEGA-IDTQNKPITSEKIKELVVTQLGYDTRVTILGHVQRGGTPS-----------------AFDRILASRMG 326
Cdd:PLN02884 274 GSAVVCVAEGAgQDLLQKTNATDASGNPVLGDIGVHLQQEIKKHFKDIGVPAdvkyidptymiracranASDAILCTVLG 353

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|.
gi 11321601  327 VEAVIAlleATPDTPACVVSLNGNHAVRLPLMECVQMTQDV 367
Cdd:PLN02884 354 QNAVHG---AFAGFSGITVGICNTHYVYLPIPEVIAYPRRV 391
PRK06555 PRK06555
pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated
 25-231 1.20e-10

pyrophosphate--fructose-6-phosphate 1-phosphotransferase; Validated


Pssm-ID: 180620 [Multi-domain]  Cd Length: 403  Bit Score: 64.26  E-value: 1.20e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   25 KAIGVLTSGGDAQGMNAAVRAVVRMGIYVGAKVYFIY--EGYQGMVDGGS-NIAEADWESVSSILQVGGTIIGSARCQAF 101
Cdd:PRK06555   4 KKVALLTAGGLAPCLSSAVGGLIERYTEIAPEVEIIAyrSGYQGLLLGDSiEITPAVRANAGLLHRYGGSPIGNSRVKLT 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  102 RT---------REGR--LKAACNLLQR-GITNLCVIGGDGSLTGAnlfrkewSGLLEELARNGqidkeavqkYAyLNVVG 169
Cdd:PRK06555  84 NVadcvkrglvKEGEnpLKVAAERLAAdGVDILHTIGGDDTNTTA-------ADLAAYLAENG---------YD-LTVVG 146

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 11321601  170 MVGSIDNDFCGTDMTIGTDSALHRIIEVVDAIMTTAQSHQRTFVL-EVMGRHCGYLALVSALA 231
Cdd:PRK06555 147 LPKTIDNDVVPIRQSLGAWTAAEQGARFFDNVINEHSANPRMLIIhEVMGRNCGWLTAATARA 209
PTZ00286 PTZ00286
6-phospho-1-fructokinase; Provisional
 413-591 1.33e-09

6-phospho-1-fructokinase; Provisional


Pssm-ID: 185539  Cd Length: 459  Bit Score: 61.21  E-value: 1.33e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  413 VAVINVGAPAAGMNAAVRSAVRVGIADGH--RMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvlPGKYLEE 490
Cdd:PTZ00286  90 AGIVTCGGLCPGLNVVIRELVMNLINNYGvkTIYGAKYGYKGLYKEDWIKLDPKDVKTIHRLGGTILGSSR--GGFDPKV 167

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  491 IATQMRTHSINALLIIGGFEAYLGLLELS--AAREKHEefcVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQ 568
Cdd:PTZ00286 168 MVDTLIRHGINILFTLGGDGTHRGALAIYkeLRRRKLN---ISVVGIPKTIDNDIPIIDESFGFQTAVEEAQNAIRAAYV 244

                        170       180
                 ....*....|....*....|...
gi 11321601  569 SASGTKRRVFIIETMGGYCGYLA 591
Cdd:PTZ00286 245 EAKSAKNGVGIVKLMGRDSGFIA 267
PTZ00287 PTZ00287
6-phosphofructokinase; Provisional
 27-277 5.81e-06

6-phosphofructokinase; Provisional


Pssm-ID: 240345 [Multi-domain]  Cd Length: 1419  Bit Score: 50.04  E-value: 5.81e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601    27 IGVLTSGGDAQGMNAAVRavvrmGIYVGAKVYFIYEGYQGMVDGGSNIAEADWESVSSIL-----QVGG-TIIGSARCQA 100
Cdd:PTZ00287  180 IGIILSGGPAPGGHNVIS-----GIYDYAKRYNEQSQVIGFLGGIDGLYSKNYVTITDSLmnrfrNLGGfNMLWSGRGKV 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   101 fRTREGRLKAACNLLQRGITNLCVIGGDGSLTGAnlfrkewsGLLEELARNGQIDkeavqkyayLNVVGMVGSIDNDFC- 179
Cdd:PTZ00287  255 -RNKDDLIAIENIVAKLKLNGLVIIGGDGSNSNA--------ALISEYFAERQIP---------ISIIGIPKTIDGDLKs 316

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   180 -GTDMTIGTDSALHRIIEVVDAIMTTAQS-HQRTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWEEQMCVK-- 255
Cdd:PTZ00287  317 eAIEISFGFDTATKTYSEVIGNLCTDVKTgHNVYHVVRVMGRSASHVVLECALQTRPNIVLIGEEVEKENLSLKDIVSni 396

                         250       260
                  ....*....|....*....|....*
gi 11321601   256 ---LSENRARKKRLNIIIVAEGAID 277
Cdd:PTZ00287  397 vntILKRRSLNKNYGVILIPEGLIE 421
PLN02884 PLN02884
6-phosphofructokinase
 412-591 8.47e-06

6-phosphofructokinase


Pssm-ID: 178472 [Multi-domain]  Cd Length: 411  Bit Score: 49.04  E-value: 8.47e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  412 NVAVINVGAPAAGMNAAVRSAV-RVGIADGHRMLAIYDGFDGFAKGQIKEIGWTD--VGGWTGQGGSILGTKRvlPGKYL 488
Cdd:PLN02884  55 KAAIVTCGGLCPGLNDVIRQIVfTLEIYGVKNIVGIPFGYRGFFEKGLSEMPLSRkvVQNIHLSGGSLLGVSR--GGAKT 132

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  489 EEIATQMRTHSINALLIIGGFEAYLGllelsaAREKHEEfC------VPMVMVPATVSNNVPGSDFSIGADTALNTITDT 562
Cdd:PLN02884 133 SDIVDSIEARGINMLFVLGGNGTHAG------ANAIHNE-CrkrkmkVSVVGVPKTIDNDILLMDKTFGFDTAVEEAQRA 205

                        170       180
                 ....*....|....*....|....*....
gi 11321601  563 CDRIKQSASGTKRRVFIIETMGGYCGYLA 591
Cdd:PLN02884 206 INSAYIEAHSAYHGIGLVKLMGRSSGFIA 234
PTZ00468 PTZ00468
phosphofructokinase family protein; Provisional
 25-305 1.16e-05

phosphofructokinase family protein; Provisional


Pssm-ID: 185647 [Multi-domain]  Cd Length: 1328  Bit Score: 49.20  E-value: 1.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601    25 KAIGVLTSGGDAQGMNAAVRAVVRmgiYV-----GAKVYFIYEGYQGMVDggSNIAEADWESVSSILQVGG-TIIGSARc 98
Cdd:PTZ00468  103 RRIGVVLSGGQASGGHNVIAGLMS---YIklcnqSSQLFGFLGGPEGVYS--ERYRELTEDDINGILNQGGfNIICSGR- 176

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601    99 QAFRTREgRLKAACNLLQR-GITNLCVIGGDGSLTGANLfrkewsgLLEELARNGqidkeavqkyAYLNVVGMVGSIDND 177
Cdd:PTZ00468  177 HKIETEE-QMRASLEICEKlKLHGLVVIGGDDSNTNAAV-------LAEYFKRNS----------SSTVVVGCPKTIDGD 238

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   178 FCG--TDMTIGTDSALHRIIEVVDAIMTTAQSHQ-RTFVLEVMGRHCGYLALVSALACGADWVFLPESPPEEGWE----- 249
Cdd:PTZ00468  239 LKNevIETSFGYDTAVKTYSEQIGSIMDAIKTEGyGYYFVRLMGRSASHITLECGLQTRANMILIGEEIKEENRSlmsiv 318

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 11321601   250 EQMCVKLSENRARKKRLNIIIVAEGAIDTqnKPITSEKIKELVVTQLGYDTRVTIL 305
Cdd:PTZ00468  319 DEIVEMILKRDSLGKKHGIVLLPEGLIEF--IPEFETLIKELNLILLKTNDRKQII 372
PLN02564 PLN02564
6-phosphofructokinase
 424-591 4.76e-05

6-phosphofructokinase


Pssm-ID: 178178  Cd Length: 484  Bit Score: 46.66  E-value: 4.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  424 GMNAAVRSAVrVGIADG---HRMLAIYDGFDGFAKGQIKEIGWTDVGGWTGQGGSILGTKRvlPGKYLEEIATQMRTHSI 500
Cdd:PLN02564 101 GLNTVIREIV-CGLSYMygvTRILGIDGGYRGFYSRNTIPLTPKVVNDIHKRGGTILGTSR--GGHDTSKIVDSIQDRGI 177

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601  501 NALLIIGGFEAYLGllelsaAREKHEE-----FCVPMVMVPATVSNNVPGSDFSIGADTALNTITDTCDRIKQSASGTKR 575
Cdd:PLN02564 178 NQVYIIGGDGTQKG------ASVIYEEirrrgLKVAVAGIPKTIDNDIPVIDKSFGFDTAVEEAQRAINAAHVEAESVEN 251

                        170
                 ....*....|....*.
gi 11321601  576 RVFIIETMGGYCGYLA 591
Cdd:PLN02564 252 GIGLVKLMGRYSGFIA 267
PRK07085 PRK07085
diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional
 27-230 1.48e-03

diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional


Pssm-ID: 235930  Cd Length: 555  Bit Score: 41.83  E-value: 1.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   27 IGVLTSGGDAQG-MNaavravVRMGIYVGAKVY--------FIyEGYQGMVDGgsNIAEADWESVSSILQVGG-TIIGSA 96
Cdd:PRK07085  73 VGVILSGGQAPGgHN------VIAGLFDGLKKLnpdsklfgFI-GGPLGLLNG--KYIEITEEVIDEYRNTGGfDMIGSG 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 11321601   97 RCQaFRTREGRLKAACNLLQRGITNLCVIGGDGSLTGANLfrkewsgLLEELARNGqidkeavqkyAYLNVVGMVGSIDN 176
Cdd:PRK07085 144 RTK-IETEEQKEACLETVKKLKLDGLVIIGGDDSNTNAAI-------LAEYFAKHG----------CKTQVIGVPKTIDG 205

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 11321601  177 DFCGT--DMTIGTDSALHRIIEVVDAIMTTAQSHQRT--FVlEVMGRHCGYLALVSAL 230
Cdd:PRK07085 206 DLKNEfiETSFGFDTATKTYSEMIGNISRDALSAKKYwhFI-KLMGRSASHIALECAL 262
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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