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Conserved domains on  [gi|25777671|ref|NP_002705|]
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serine/threonine-protein phosphatase 1 regulatory subunit 10 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TFIIS_I super family cl00146
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ...
 102-146 2.31e-10

N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme


The actual alignment was detected with superfamily member smart00509:

Pssm-ID: 469629 [Multi-domain]  Cd Length: 75  Bit Score: 57.32  E-value: 2.31e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 25777671    102 PLTVDHLKQNNTAKLVKQLSKSSeDEELRKLASVLVSDWMAVIRS 146
Cdd:smart00509  32 PITVDLLEETRIGKKVNGLRKHK-NEEIRKLAKKLIKSWKKLVYS 75
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
909-932 1.49e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


:

Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 39.48  E-value: 1.49e-04
                          10        20
                  ....*....|....*....|....
gi 25777671   909 RPVCRHFMMKGNCRYENNCAFYHP 932
Cdd:pfam00642   3 TELCRFFLRTGYCKYGDRCKFAHG 26
 
Name Accession Description Interval E-value
TFS2N smart00509
Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);
102-146 2.31e-10

Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);


Pssm-ID: 197766 [Multi-domain]  Cd Length: 75  Bit Score: 57.32  E-value: 2.31e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 25777671    102 PLTVDHLKQNNTAKLVKQLSKSSeDEELRKLASVLVSDWMAVIRS 146
Cdd:smart00509  32 PITVDLLEETRIGKKVNGLRKHK-NEEIRKLAKKLIKSWKKLVYS 75
Med26 pfam08711
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ...
 102-144 1.29e-09

TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.


Pssm-ID: 462573 [Multi-domain]  Cd Length: 52  Bit Score: 54.44  E-value: 1.29e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 25777671   102 PLTVDHLKQNNTAKLVKQLSKSSEDEELRKLASVLVSDWMAVI 144
Cdd:pfam08711  10 PVTLELLKSTGIGKVVNKLRKHKENPEIKKLAKELVKKWKRLV 52
TFIIS_I cd00183
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ...
 102-145 1.46e-09

N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme


Pssm-ID: 238107  Cd Length: 76  Bit Score: 55.01  E-value: 1.46e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 25777671 102 PLTVDHLKQNNTAKLVKQLSKSSeDEELRKLASVLVSDWMAVIR 145
Cdd:cd00183  34 PLTVEILKETRIGKKVNSLRKHS-NEKIRKLAKALIKSWKKLVD 76
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
909-932 1.49e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 39.48  E-value: 1.49e-04
                          10        20
                  ....*....|....*....|....
gi 25777671   909 RPVCRHFMMKGNCRYENNCAFYHP 932
Cdd:pfam00642   3 TELCRFFLRTGYCKYGDRCKFAHG 26
ZnF_C3H1 smart00356
zinc finger;
910-932 2.56e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.76  E-value: 2.56e-04
                           10        20
                   ....*....|....*....|...
gi 25777671    910 PVCRHFMmKGNCRYENNCAFYHP 932
Cdd:smart00356   5 ELCKFFK-RGYCPRGDRCKFAHP 26
 
Name Accession Description Interval E-value
TFS2N smart00509
Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);
102-146 2.31e-10

Domain in the N-terminus of transcription elongation factor S-II (and elsewhere);


Pssm-ID: 197766 [Multi-domain]  Cd Length: 75  Bit Score: 57.32  E-value: 2.31e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 25777671    102 PLTVDHLKQNNTAKLVKQLSKSSeDEELRKLASVLVSDWMAVIRS 146
Cdd:smart00509  32 PITVDLLEETRIGKKVNGLRKHK-NEEIRKLAKKLIKSWKKLVYS 75
Med26 pfam08711
TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is ...
 102-144 1.29e-09

TFIIS helical bundle-like domain; Mediator is a large complex of up to 33 proteins that is conserved from plants to fungi to humans - the number and representation of individual subunits varying with species {1-2]. It is arranged into four different sections, a core, a head, a tail and a kinase-activity part, and the number of subunits within each of these is what varies with species. Overall, Mediator regulates the transcriptional activity of RNA polymerase II but it would appear that each of the four different sections has a slightly different function. Mediator exists in two major forms in human cells: a smaller form that interacts strongly with pol II and activates transcription, and a large form that does not interact strongly with pol II and does not directly activate transcription. Notably, the 'small' and 'large' Mediator complexes differ in their subunit composition: the Med26 subunit preferentially associates with the small, active complex, whereas cdk8, cyclin C, Med12 and Med13 associate with the large Mediator complex. This family includesthe C terminal region of a number of eukaryotic hypothetical proteins which are homologous to the Saccharomyces cerevisiae protein IWS1. IWS1 is known to be an Pol II transcription elongation factor and interacts with Spt6 and Spt5.


Pssm-ID: 462573 [Multi-domain]  Cd Length: 52  Bit Score: 54.44  E-value: 1.29e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 25777671   102 PLTVDHLKQNNTAKLVKQLSKSSEDEELRKLASVLVSDWMAVI 144
Cdd:pfam08711  10 PVTLELLKSTGIGKVVNKLRKHKENPEIKKLAKELVKKWKRLV 52
TFIIS_I cd00183
N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a ...
 102-145 1.46e-09

N-terminal domain (domain I) of transcription elongation factor S-II (TFIIS); similar to a domain found in elongin A and CRSP70; likely to be involved in transcription; domain I from TFIIS interacts with RNA polymerase II holoenzyme


Pssm-ID: 238107  Cd Length: 76  Bit Score: 55.01  E-value: 1.46e-09
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 25777671 102 PLTVDHLKQNNTAKLVKQLSKSSeDEELRKLASVLVSDWMAVIR 145
Cdd:cd00183  34 PLTVEILKETRIGKKVNSLRKHS-NEKIRKLAKALIKSWKKLVD 76
zf-CCCH pfam00642
Zinc finger C-x8-C-x5-C-x3-H type (and similar);
909-932 1.49e-04

Zinc finger C-x8-C-x5-C-x3-H type (and similar);


Pssm-ID: 459885 [Multi-domain]  Cd Length: 27  Bit Score: 39.48  E-value: 1.49e-04
                          10        20
                  ....*....|....*....|....
gi 25777671   909 RPVCRHFMMKGNCRYENNCAFYHP 932
Cdd:pfam00642   3 TELCRFFLRTGYCKYGDRCKFAHG 26
ZnF_C3H1 smart00356
zinc finger;
910-932 2.56e-04

zinc finger;


Pssm-ID: 214632 [Multi-domain]  Cd Length: 27  Bit Score: 38.76  E-value: 2.56e-04
                           10        20
                   ....*....|....*....|...
gi 25777671    910 PVCRHFMmKGNCRYENNCAFYHP 932
Cdd:smart00356   5 ELCKFFK-RGYCPRGDRCKFAHP 26
zf-CCCH_4 pfam18044
CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and ...
 910-932 4.91e-04

CCCH-type zinc finger; This short zinc binding domain has the pattern of three cysteines and one histidine to coordinate the zinc ion. This domain is found in a wide variety of proteins such as E3 ligases.


Pssm-ID: 465626  Cd Length: 22  Bit Score: 37.95  E-value: 4.91e-04
                          10        20
                  ....*....|....*....|...
gi 25777671   910 PVCRHFMmKGNCRYENNCAFYHP 932
Cdd:pfam18044   1 RLCRYFQ-KGGCRYGDNCRFSHD 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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