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Conserved domains on  [gi|66932916|ref|NP_002736|]
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mitogen-activated protein kinase 1 [Homo sapiens]

Protein Classification

mitogen-activated protein kinase( domain architecture ID 10167605)

mitogen-activated protein kinase (MAPK) is a serine/threonine-protein kinase that catalyzes the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates, and acts as an essential component of the MAPK signal transduction pathway

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
STKc_ERK1_2_like cd07849
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine ...
19-353 0e+00

Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the mitogen-activated protein kinases (MAPKs) ERK1, ERK2, baker's yeast Fus3, and similar proteins. MAPK pathways are important mediators of cellular responses to extracellular signals. ERK1/2 activation is preferentially by mitogenic factors, differentiation stimuli, and cytokines, through a kinase cascade involving the MAPK kinases MEK1/2 and a MAPK kinase kinase from the Raf family. ERK1/2 have numerous substrates, many of which are nuclear and participate in transcriptional regulation of many cellular processes. They regulate cell growth, cell proliferation, and cell cycle progression from G1 to S phase. Although the distinct roles of ERK1 and ERK2 have not been fully determined, it is known that ERK2 can maintain most functions in the absence of ERK1, and that the deletion of ERK2 is embryonically lethal. The MAPK, Fus3, regulates yeast mating processes including mating-specific gene expression, G1 arrest, mating projection, and cell fusion. This ERK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


:

Pssm-ID: 270839 [Multi-domain]  Cd Length: 336  Bit Score: 723.32  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQM 98
Cdd:cd07849   1 FDVGPRYQNLSYIGEGAYGMVCSAVHKPTGQKVAIKKISPFEHQTYCLRTLREIKILLRFKHENIIGILDIQRPPTFESF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDH 178
Cdd:cd07849  81 KDVYIVQELMETDLYKLIKTQHLSNDHIQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTNCDLKICDFGLARIADPEH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINL 258
Cdd:cd07849 161 DHTGFLTEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLSNRPLFPGKDYLHQLNLILGILGTPSQEDLNCIISL 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 259 KARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMEL-DD 337
Cdd:cd07849 241 KARNYIKSLPFKPKVPWNKLFPNADPKALDLLDKMLTFNPHKRITVEEALAHPYLEQYHDPSDEPVAEEPFPFDMELfDD 320
                       330
                ....*....|....*.
gi 66932916 338 LPKEKLKELIFEETAR 353
Cdd:cd07849 321 LPKEKLKELIFEEIMR 336
 
Name Accession Description Interval E-value
STKc_ERK1_2_like cd07849
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine ...
19-353 0e+00

Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the mitogen-activated protein kinases (MAPKs) ERK1, ERK2, baker's yeast Fus3, and similar proteins. MAPK pathways are important mediators of cellular responses to extracellular signals. ERK1/2 activation is preferentially by mitogenic factors, differentiation stimuli, and cytokines, through a kinase cascade involving the MAPK kinases MEK1/2 and a MAPK kinase kinase from the Raf family. ERK1/2 have numerous substrates, many of which are nuclear and participate in transcriptional regulation of many cellular processes. They regulate cell growth, cell proliferation, and cell cycle progression from G1 to S phase. Although the distinct roles of ERK1 and ERK2 have not been fully determined, it is known that ERK2 can maintain most functions in the absence of ERK1, and that the deletion of ERK2 is embryonically lethal. The MAPK, Fus3, regulates yeast mating processes including mating-specific gene expression, G1 arrest, mating projection, and cell fusion. This ERK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270839 [Multi-domain]  Cd Length: 336  Bit Score: 723.32  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQM 98
Cdd:cd07849   1 FDVGPRYQNLSYIGEGAYGMVCSAVHKPTGQKVAIKKISPFEHQTYCLRTLREIKILLRFKHENIIGILDIQRPPTFESF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDH 178
Cdd:cd07849  81 KDVYIVQELMETDLYKLIKTQHLSNDHIQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTNCDLKICDFGLARIADPEH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINL 258
Cdd:cd07849 161 DHTGFLTEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLSNRPLFPGKDYLHQLNLILGILGTPSQEDLNCIISL 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 259 KARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMEL-DD 337
Cdd:cd07849 241 KARNYIKSLPFKPKVPWNKLFPNADPKALDLLDKMLTFNPHKRITVEEALAHPYLEQYHDPSDEPVAEEPFPFDMELfDD 320
                       330
                ....*....|....*.
gi 66932916 338 LPKEKLKELIFEETAR 353
Cdd:cd07849 321 LPKEKLKELIFEEIMR 336
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
25-313 1.45e-90

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 272.10  E-value: 1.45e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916     25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTieqmkDVYIV 104
Cdd:smart00220   1 YEILEKLGEGSFGKVYLARDKKTGKLVAIKVIKKKKIKKDRERILREIKILKKLKHPNIVRLYDVFEDED-----KLYLV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916    105 QDLMET-DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPdhdhTG 182
Cdd:smart00220  76 MEYCEGgDLFDLLKKRgRLSEDEARFYLRQILSALEYLHSKGIVHRDLKPENILLDEDGHVKLADFGLARQLDP----GE 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916    183 FLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhylDQLNHILGILGSPsqedlnciinlkarn 262
Cdd:smart00220 152 KLTTFVGTPEYMAPEV-LLGKGYGKAVDIWSLGVILYELLTGKPPFPGD---DQLLELFKKIGKP--------------- 212
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 66932916    263 yllslphknKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:smart00220 213 ---------KPPFPPPEWDISPEAKDLIRKLLVKDPEKRLTAEEALQHPFF 254
PTZ00024 PTZ00024
cyclin-dependent protein kinase; Provisional
19-331 1.58e-69

cyclin-dependent protein kinase; Provisional


Pssm-ID: 240233 [Multi-domain]  Cd Length: 335  Bit Score: 221.17  E-value: 1.58e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   19 FDVGPRYTNL-SYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQR-------------TLREIKILLRFRHENII 84
Cdd:PTZ00024   4 FSISERYIQKgAHLGEGTYGKVEKAYDTLTGKIVAIKKVKIIEISNDVTKdrqlvgmcgihftTLRELKIMNEIKHENIM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   85 GINDIIraptIEQmKDVYIVQDLMETDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL 163
Cdd:PTZ00024  84 GLVDVY----VEG-DFINLVMDIMASDLKKVVDRKiRLTESQVKCILLQILNGLNVLHKWYFMHRDLSPANIFINSKGIC 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  164 KICDFGLAR--VADPDHDHTGF---------LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH 232
Cdd:PTZ00024 159 KIADFGLARryGYPPYSDTLSKdetmqrreeMTSKVVTLWYRAPELLMGAEKYHFAVDMWSVGCIFAELLTGKPLFPGEN 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  233 YLDQLNHILGILGSPSQEDLNciinlKARNYLLSLP--HKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAH 310
Cdd:PTZ00024 239 EIDQLGRIFELLGTPNEDNWP-----QAKKLPLYTEftPRKPKDLKTIFPNASDDAIDLLQSLLKLNPLERISAKEALKH 313
                        330       340
                 ....*....|....*....|.
gi 66932916  311 PYLEQYYDPSDepIAEAPFKF 331
Cdd:PTZ00024 314 EYFKSDPLPCD--PSQLPFNF 332
Pkinase pfam00069
Protein kinase domain;
25-313 2.46e-48

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 162.41  E-value: 2.46e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916    25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPfEHQT--YCQRTLREIKILLRFRHENIIGINDIIRAPtieqmKDVY 102
Cdd:pfam00069   1 YEVLRKLGSGSFGTVYKAKHRDTGKIVAIKKIKK-EKIKkkKDKNILREIKILKKLNHPNIVRLYDAFEDK-----DNLY 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   103 IVQDLME-TDLYKLLKTQ-HLSNDHICYFLYQILRGLKyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdH 180
Cdd:pfam00069  75 LVLEYVEgGSLFDLLSEKgAFSEREAKFIMKQILEGLE-----------------------------------------S 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   181 TGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsqedlnciinlka 260
Cdd:pfam00069 114 GSSLTTFVGTPWYMAPEV-LGGNPYGPKVDVWSLGCILYELLTGKPPFPGINGNEIYELII------------------- 173
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 66932916   261 rnyllslphKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:pfam00069 174 ---------DQPYAFPELPSNLSEEAKDLLKKLLKKDPSKRLTATQALQHPWF 217
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
21-310 4.45e-45

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 160.95  E-value: 4.45e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  21 VGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISP--FEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIeqm 98
Cdd:COG0515   5 LLGRYRILRLLGRGGMGVVYLARDLRLGRPVALKVLRPelAADPEARERFRREARALARLNHPNIVRVYDVGEEDGR--- 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 kdVYIVQDLME-TDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD- 175
Cdd:COG0515  82 --PYLVMEYVEgESLADLLRRRgPLPPAEALRILAQLAEALAAAHAAGIVHRDIKPANILLTPDGRVKLIDFGIARALGg 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 PDHDHTGFLteyVATRWYRAPEIMLNSKGYTKSiDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsqedlnci 255
Cdd:COG0515 160 ATLTQTGTV---VGTPGYMAPEQARGEPVDPRS-DVYSLGVTLYELLTGRPPFDGDSPAELLRAHL-------------- 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 256 inlkarnyllslpHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI----EVEQALAH 310
Cdd:COG0515 222 -------------REPPPPPSELRPDLPPALDAIVLRALAKDPEERYqsaaELAAALRA 267
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
24-230 5.59e-17

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 82.15  E-value: 5.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   24 RYTNLSYIGEGayGM--VCSAYDNVNKVRVAIKKIspfeHQTYCqrtlREIKILLRFRHE--NIIGINDiiraPTIEQMK 99
Cdd:NF033483   8 RYEIGERIGRG--GMaeVYLAKDTRLDRDVAVKVL----RPDLA----RDPEFVARFRREaqSAASLSH----PNIVSVY 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  100 DV-------YIVqdlME----TDLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICD 167
Cdd:NF033483  74 DVgedggipYIV---MEyvdgRTLKDYIREHGpLSPEEAVEIMIQILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTD 150
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916  168 FGLAR-VADPDHDHTGFLteyVATRWYRAPEIMLNSKGYTKSiDIWSVGCILAEMLSNRPIFPG 230
Cdd:NF033483 151 FGIARaLSSTTMTQTNSV---LGTVHYLSPEQARGGTVDARS-DIYSLGIVLYEMLTGRPPFDG 210
TOMM_kin_cyc TIGR03903
TOMM system kinase/cyclase fusion protein; This model represents proteins of 1350 in length, ...
50-230 9.60e-12

TOMM system kinase/cyclase fusion protein; This model represents proteins of 1350 in length, in multiple species of Burkholderia, in Acidovorax avenae subsp. citrulli AAC00-1 and Delftia acidovorans SPH-1, and in multiple copies in Sorangium cellulosum, in genomic neighborhoods that include a cyclodehydratase/docking scaffold fusion protein (TIGR03882) and a member of the thiazole/oxazole modified metabolite (TOMM) precursor family TIGR03795. It has a kinase domain in the N-terminal 300 amino acids, followed by a cyclase homology domain, followed by regions without named domain definitions. It is a probable bacteriocin-like metabolite biosynthesis protein. [Cellular processes, Toxin production and resistance]


Pssm-ID: 274846 [Multi-domain]  Cd Length: 1266  Bit Score: 66.41  E-value: 9.60e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916     50 RVAIK--KISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTieqmKDVYIVQDLME-TDLYKLLKTQH-LSNDH 125
Cdd:TIGR03903    5 EVAIKllRTDAPEEEHQRARFRRETALCARLYHPNIVALLDSGEAPP----GLLFAVFEYVPgRTLREVLAADGaLPAGE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916    126 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFGLAR----VADPDHDHTGFLTEYVATRWYRAPEi 198
Cdd:TIGR03903   81 TGRLMLQVLDALACAHNQGIVHRDLKPQNIMVSQTGVrphAKVLDFGIGTllpgVRDADVATLTRTTEVLGTPTYCAPE- 159
                          170       180       190
                   ....*....|....*....|....*....|..
gi 66932916    199 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 230
Cdd:TIGR03903  160 QLRGEPVTPNSDLYAWGLIFLECLTGQRVVQG 191
 
Name Accession Description Interval E-value
STKc_ERK1_2_like cd07849
Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine ...
19-353 0e+00

Catalytic domain of Extracellular signal-Regulated Kinase 1 and 2-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the mitogen-activated protein kinases (MAPKs) ERK1, ERK2, baker's yeast Fus3, and similar proteins. MAPK pathways are important mediators of cellular responses to extracellular signals. ERK1/2 activation is preferentially by mitogenic factors, differentiation stimuli, and cytokines, through a kinase cascade involving the MAPK kinases MEK1/2 and a MAPK kinase kinase from the Raf family. ERK1/2 have numerous substrates, many of which are nuclear and participate in transcriptional regulation of many cellular processes. They regulate cell growth, cell proliferation, and cell cycle progression from G1 to S phase. Although the distinct roles of ERK1 and ERK2 have not been fully determined, it is known that ERK2 can maintain most functions in the absence of ERK1, and that the deletion of ERK2 is embryonically lethal. The MAPK, Fus3, regulates yeast mating processes including mating-specific gene expression, G1 arrest, mating projection, and cell fusion. This ERK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270839 [Multi-domain]  Cd Length: 336  Bit Score: 723.32  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQM 98
Cdd:cd07849   1 FDVGPRYQNLSYIGEGAYGMVCSAVHKPTGQKVAIKKISPFEHQTYCLRTLREIKILLRFKHENIIGILDIQRPPTFESF 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDH 178
Cdd:cd07849  81 KDVYIVQELMETDLYKLIKTQHLSNDHIQYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTNCDLKICDFGLARIADPEH 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINL 258
Cdd:cd07849 161 DHTGFLTEYVATRWYRAPEIMLNSKGYTKAIDIWSVGCILAEMLSNRPLFPGKDYLHQLNLILGILGTPSQEDLNCIISL 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 259 KARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMEL-DD 337
Cdd:cd07849 241 KARNYIKSLPFKPKVPWNKLFPNADPKALDLLDKMLTFNPHKRITVEEALAHPYLEQYHDPSDEPVAEEPFPFDMELfDD 320
                       330
                ....*....|....*.
gi 66932916 338 LPKEKLKELIFEETAR 353
Cdd:cd07849 321 LPKEKLKELIFEEIMR 336
STKc_MAPK cd07834
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs ...
24-350 0e+00

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Typical MAPK pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPK kinase (MAP2K or MKK), which itself is phosphorylated and activated by a MAPK kinase kinase (MAP3K or MKKK). Each cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. There are three typical MAPK subfamilies: Extracellular signal-Regulated Kinase (ERK), c-Jun N-terminal Kinase (JNK), and p38. Some MAPKs are atypical in that they are not regulated by MAP2Ks. These include MAPK4, MAPK6, NLK, and ERK7. The MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270828 [Multi-domain]  Cd Length: 329  Bit Score: 562.92  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVY 102
Cdd:cd07834   1 RYELLKPIGSGAYGVVCSAYDKRTGRKVAIKKISnVFDDLIDAKRILREIKILRHLKHENIIGLLDILRPPSPEEFNDVY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDhT 181
Cdd:cd07834  81 IVTELMETDLHKVIKSpQPLTDDHIQYFLYQILRGLKYLHSAGVIHRDLKPSNILVNSNCDLKICDFGLARGVDPDED-K 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKAR 261
Cdd:cd07834 160 GFLTEYVVTRWYRAPELLLSSKKYTKAIDIWSVGCIFAELLTRKPLFPGRDYIDQLNLIVEVLGTPSEEDLKFISSEKAR 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 262 NYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKF-DMELDDLPK 340
Cdd:cd07834 240 NYLKSLPKKPKKPLSEVFPGASPEAIDLLEKMLVFNPKKRITADEALAHPYLAQLHDPEDEPVAKPPFDFpFFDDEELTI 319
                       330
                ....*....|
gi 66932916 341 EKLKELIFEE 350
Cdd:cd07834 320 EELKELIYEE 329
STKc_TEY_MAPK cd07858
Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; ...
19-356 1.10e-171

Catalytic domain of the Serine/Threonine Kinases, Plant TEY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TEY subtype of plant MAPKs and is further subdivided into three groups (A, B, and C). Group A is represented by AtMPK3, AtMPK6, Nicotiana tabacum BTF4 (NtNTF4), among others. They are mostly involved in environmental and hormonal responses. AtMPK3 and AtMPK6 are also key regulators for stomatal development and patterning. Group B is represented by AtMPK4, AtMPK13, and NtNTF6, among others. They may be involved in both cell division and environmental stress response. AtMPK4 also participates in regulating innate immunity. Group C is represented by AtMPK1, AtMPK2, NtNTF3, Oryza sativa MAPK4 (OsMAPK4), among others. They may also be involved in stress responses. AtMPK1 and AtMPK2 are activated following mechanical injury and in the presence of stress chemicals such as jasmonic acid, hydrogen peroxide and abscisic acid. OsMAPK4 is also called OsMSRMK3 for Multiple Stress-Responsive MAPK3. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20. The TEY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143363 [Multi-domain]  Cd Length: 337  Bit Score: 481.10  E-value: 1.10e-171
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQ 97
Cdd:cd07858   1 FEVDTKYVPIKPIGRGAYGIVCSAKNSETNEKVAIKKIAnAFDNRIDAKRTLREIKLLRHLDHENVIAIKDIMPPPHREA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  98 MKDVYIVQDLMETDLYKLLK-TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADP 176
Cdd:cd07858  81 FNDVYIVYELMDTDLHQIIRsSQTLSDDHCQYFLYQLLRGLKYIHSANVLHRDLKPSNLLLNANCDLKICDFGLARTTSE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 DHDhtgFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
Cdd:cd07858 161 KGD---FMTEYVVTRWYRAPELLLNCSEYTTAIDVWSVGCIFAELLGRKPLFPGKDYVHQLKLITELLGSPSEEDLGFIR 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 257 NLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELD 336
Cdd:cd07858 238 NEKARRYIRSLPYTPRQSFARLFPHANPLAIDLLEKMLVFDPSKRITVEEALAHPYLASLHDPSDEPVCQTPFSFDFEED 317
                       330       340
                ....*....|....*....|
gi 66932916 337 DLPKEKLKELIFEETARFQP 356
Cdd:cd07858 318 ALTEEDIKELIYNEMLAYHP 337
STKc_ERK5 cd07855
Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; ...
19-350 2.24e-162

Catalytic domain of the Serine/Threonine Kinase, Extracellular signal-Regulated Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ERK5 (also called Big MAPK1 (BMK1) or MAPK7) has a unique C-terminal extension, making it approximately twice as big as other MAPKs. This extension contains transcriptional activation capability which is inhibited by the N-terminal half. ERK5 is activated in response to growth factors and stress by a cascade that leads to its phosphorylation by the MAP2K MEK5, which in turn is regulated by the MAP3Ks MEKK2 and MEKK3. Activated ERK5 phosphorylates its targets including myocyte enhancer factor 2 (MEF2), Sap1a, c-Myc, and RSK. It plays a role in EGF-induced cell proliferation during the G1/S phase transition. Studies on knockout mice revealed that ERK5 is essential for cardiovascular development and plays an important role in angiogenesis. It is also critical for neural differentiation and survival. The ERK5 pathway has been implicated in the pathogenesis of many diseases including cancer, cardiac hypertrophy, and atherosclerosis. MAPKs are important mediators of cellular responses to extracellular signals. The ERK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270842 [Multi-domain]  Cd Length: 336  Bit Score: 457.60  E-value: 2.24e-162
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAP-TIE 96
Cdd:cd07855   1 FDVGDRYEPIETIGSGAYGVVCSAIDTKSGQKVAIKKIPnAFDVVTTAKRTLRELKILRHFKHDNIIAIRDILRPKvPYA 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 QMKDVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD 175
Cdd:cd07855  81 DFKDVYVVLDLMESDLHHIIHSdQPLTLEHIRYFLYQLLRGLKYIHSANVIHRDLKPSNLLVNENCELKIGDFGMARGLC 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 PDH-DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC 254
Cdd:cd07855 161 TSPeEHKYFMTEYVATRWYRAPELMLSLPEYTQAIDMWSVGCIFAEMLGRRQLFPGKNYVHQLQLILTVLGTPSQAVINA 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 255 IINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDME 334
Cdd:cd07855 241 IGADRVRRYIQNLPNKQPVPWETLYPKADQQALDLLSQMLRFDPSERITVAEALQHPFLAKYHDPDDEPDCAPPFDFDFD 320
                       330
                ....*....|....*.
gi 66932916 335 LDDLPKEKLKELIFEE 350
Cdd:cd07855 321 AEALTREALKEAIVNE 336
STKc_p38 cd07851
Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs ...
18-356 1.52e-150

Catalytic domain of the Serine/Threonine Kinase, p38 Mitogen-Activated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They function in the regulation of the cell cycle, cell development, cell differentiation, senescence, tumorigenesis, apoptosis, pain development and pain progression, and immune responses. p38 kinases are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. p38 substrates include other protein kinases and factors that regulate transcription, nuclear export, mRNA stability and translation. p38 kinases are drug targets for the inflammatory diseases psoriasis, rheumatoid arthritis, and chronic pulmonary disease. Vertebrates contain four isoforms of p38, named alpha, beta, gamma, and delta, which show varying substrate specificity and expression patterns. p38alpha and p38beta are ubiquitously expressed, p38gamma is predominantly found in skeletal muscle, and p38delta is found in the heart, lung, testis, pancreas, and small intestine. The p38 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143356 [Multi-domain]  Cd Length: 343  Bit Score: 427.87  E-value: 1.52e-150
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDII-RAPTI 95
Cdd:cd07851  10 VWEVPDRYQNLSPVGSGAYGQVCSAFDTKTGRKVAIKKLSrPFQSAIHAKRTYRELRLLKHMKHENVIGLLDVFtPASSL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  96 EQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD 175
Cdd:cd07851  90 EDFQDVYLVTHLMGADLNNIVKCQKLSDDHIQFLVYQILRGLKYIHSAGIIHRDLKPSNLAVNEDCELKILDFGLARHTD 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 PDhdhtgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255
Cdd:cd07851 170 DE------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGKTLFPGSDHIDQLKRIMNLVGTPDEELLKKI 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 256 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEaPFKFDMEL 335
Cdd:cd07851 244 SSESARNYIQSLPQMPKKDFKEVFSGANPLAIDLLEKMLVLDPDKRITAAEALAHPYLAEYHDPEDEPVAP-PYDQSFES 322
                       330       340
                ....*....|....*....|.
gi 66932916 336 DDLPKEKLKELIFEETARFQP 356
Cdd:cd07851 323 RDLTVDEWKELVYDEIMNFKP 343
STKc_MPK1 cd07857
Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; ...
24-350 2.19e-140

Catalytic domain of the Serine/Threonine Kinase, Fungal Mitogen-Activated Protein Kinase MPK1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs MPK1 from Saccharomyces cerevisiae, Pmk1 from Schizosaccharomyces pombe, and similar proteins. MPK1 (also called Slt2) and Pmk1 (also called Spm1) are stress-activated MAPKs that regulate the cell wall integrity pathway, and are therefore important in the maintainance of cell shape, cell wall construction, morphogenesis, and ion homeostasis. MPK1 is activated in response to cell wall stress including heat stimulation, osmotic shock, UV irradiation, and any agents that interfere with cell wall biogenesis such as chitin antagonists, caffeine, or zymolase. MPK1 is regulated by the MAP2Ks Mkk1/2, which are regulated by the MAP3K Bck1. Pmk1 is also activated by multiple stresses including elevated temperatures, hyper- or hypotonic stress, glucose deprivation, exposure to cell-wall damaging compounds, and oxidative stress. It is regulated by the MAP2K Pek1, which is regulated by the MAP3K Mkh1. MAPKs are important mediators of cellular responses to extracellular signals. The MPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173750 [Multi-domain]  Cd Length: 332  Bit Score: 401.78  E-value: 2.19e-140
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYD--NVNKVRVAIKKISP-FEHQTYCQRTLREIKILLRFR-HENIIGINDIiRAPTIEQMK 99
Cdd:cd07857   1 RYELIKELGQGAYGIVCSARNaeTSEEETVAIKKITNvFSKKILAKRALRELKLLRHFRgHKNITCLYDM-DIVFPGNFN 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 DVYIVQDLMETDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDH 178
Cdd:cd07857  80 ELYLYEELMEADLHQIIRSgQPLTDAHFQSFIYQILCGLKYIHSANVLHRDLKPGNLLVNADCELKICDFGLARGFSENP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 -DHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 257
Cdd:cd07857 160 gENAGFMTEYVATRWYRAPEIMLSFQSYTKAIDVWSVGCILAELLGRKPVFKGKDYVDQLNQILQVLGTPDEETLSRIGS 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 258 LKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDD 337
Cdd:cd07857 240 PKAQNYIRSLPNIPKKPFESIFPNANPLALDLLEKLLAFDPTKRISVEEALEHPYLAIWHDPDDEPVCQKPFDFSFESED 319
                       330
                ....*....|...
gi 66932916 338 lPKEKLKELIFEE 350
Cdd:cd07857 320 -SMEELRDMIIEE 331
STKc_MAPK15-like cd07852
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and ...
24-350 4.69e-133

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase 15 and similar MAPKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human MAPK15 is also called Extracellular signal Regulated Kinase 8 (ERK8) while the rat protein is called ERK7. ERK7 and ERK8 display both similar and different biochemical properties. They autophosphorylate and activate themselves and do not require upstream activating kinases. ERK7 is constitutively active and is not affected by extracellular stimuli whereas ERK8 shows low basal activity and is activated by DNA-damaging agents. ERK7 and ERK8 also have different substrate profiles. Genome analysis shows that they are orthologs with similar gene structures. ERK7 and ERK 8 may be involved in the signaling of some nuclear receptor transcription factors. ERK7 regulates hormone-dependent degradation of estrogen receptor alpha while ERK8 down-regulates the transcriptional co-activation androgen and glucocorticoid receptors. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK15 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270841 [Multi-domain]  Cd Length: 337  Bit Score: 383.06  E-value: 4.69e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFR-HENIIGINDIIRAptiEQMKDV 101
Cdd:cd07852   8 RYEILKKLGKGAYGIVWKAIDKKTGEVVALKKIfDAFRNATDAQRTFREIMFLQELNdHPNIIKLLNVIRA---ENDKDI 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR--VADPDHD 179
Cdd:cd07852  85 YLVFEYMETDLHAVIRANILEDIHKQYIMYQLLKALKYLHSGGVIHRDLKPSNILLNSDCRVKLADFGLARslSQLEEDD 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 259
Cdd:cd07852 165 ENPVLTDYVATRWYRAPEILLGSTRYTKGVDMWSVGCILGEMLLGKPLFPGTSTLNQLEKIIEVIGRPSAEDIESIQSPF 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 260 ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKfdMELDD-- 337
Cdd:cd07852 245 AATMLESLPPSRPKSLDELFPKASPDALDLLKKLLVFNPNKRLTAEEALRHPYVAQFHNPADEPSLPGPIV--IPLDDnk 322
                       330
                ....*....|....
gi 66932916 338 -LPKEKLKELIFEE 350
Cdd:cd07852 323 kLTVDEYRNRLYEE 336
STKc_p38alpha cd07877
Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase ...
18-356 2.59e-130

Catalytic domain of the Serine/Threonine Kinase, p38alpha Mitogen-Activated Protein Kinase (also called MAPK14); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38alpha/MAPK14 is expressed in most tissues and is the major isoform involved in the immune and inflammatory response. It is the central p38 MAPK involved in myogenesis. It plays a role in regulating cell cycle check-point transition and promoting cell differentiation. p38alpha also regulates cell proliferation and death through crosstalk with the JNK pathway. Its substrates include MAPK activated protein kinase 2 (MK2), MK5, and the transcription factors ATF2 and Mitf. p38 kinases MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143382 [Multi-domain]  Cd Length: 345  Bit Score: 376.69  E-value: 2.59e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIR-APTI 95
Cdd:cd07877  12 IWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSrPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTpARSL 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  96 EQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD 175
Cdd:cd07877  92 EEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTD 171
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 PDhdhtgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255
Cdd:cd07877 172 DE------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKI 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 256 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEaPFKFDMEL 335
Cdd:cd07877 246 SSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVAD-PYDQSFES 324
                       330       340
                ....*....|....*....|.
gi 66932916 336 DDLPKEKLKELIFEETARFQP 356
Cdd:cd07877 325 RDLLIDEWKSLTYDEVISFVP 345
STKc_Sty1_Hog1 cd07856
Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases ...
14-350 2.95e-130

Catalytic domain of the Serine/Threonine Kinases, Fungal Mitogen-Activated Protein Kinases Sty1 and Hog1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPKs Sty1 from Schizosaccharomyces pombe, Hog1 from Saccharomyces cerevisiae, and similar proteins. Sty1 and Hog1 are stress-activated MAPKs that partipate in transcriptional regulation in response to stress. Sty1 is activated in response to oxidative stress, osmotic stress, and UV radiation. It is regulated by the MAP2K Wis1, which is activated by the MAP3Ks Wis4 and Win1, which receive signals of the stress condition from membrane-spanning histidine kinases Mak1-3. Activated Sty1 stabilizes the Atf1 transcription factor and induces transcription of Atf1-dependent genes of the core environmetal stress response. Hog1 is the key element in the high osmolarity glycerol (HOG) pathway and is activated upon hyperosmotic stress. Activated Hog1 accumulates in the nucleus and regulates stress-induced transcription. The HOG pathway is mediated by two transmembrane osmosensors, Sln1 and Sho1. MAPKs are important mediators of cellular responses to extracellular signals. The Sty1/Hog1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270843 [Multi-domain]  Cd Length: 328  Bit Score: 375.76  E-value: 2.95e-130
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRA 92
Cdd:cd07856   1 IFGTVFEITTRYSDLQPVGMGAFGLVCSARDQLTGQNVAVKKImKPFSTPVLAKRTYRELKLLKHLRHENIISLSDIFIS 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  93 PtieqMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR 172
Cdd:cd07856  81 P----LEDIYFVTELLGTDLHRLLTSRPLEKQFIQYFLYQILRGLKYVHSAGVIHRDLKPSNILVNENCDLKICDFGLAR 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 VADPDhdhtgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 252
Cdd:cd07856 157 IQDPQ------MTGYVSTRYYRAPEIMLTWQKYDVEVDIWSAGCIFAEMLEGKPLFPGKDHVNQFSIITELLGTPPDDVI 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 253 NCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFKFD 332
Cdd:cd07856 231 NTICSENTLRFVQSLPKRERVPFSEKFKNADPDAIDLLEKMLVFDPKKRISAAEALAHPYLAPYHDPTDEPVADEKFDWS 310
                       330
                ....*....|....*...
gi 66932916 333 MELDDLPKEKLKELIFEE 350
Cdd:cd07856 311 FNDADLPVDTWKVMMYSE 328
STKc_p38beta cd07878
Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase ...
18-356 3.68e-128

Catalytic domain of the Serine/Threonine Kinase, p38beta Mitogen-Activated Protein Kinase (also called MAPK11); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38beta/MAPK11 is widely expressed in tissues and shows more similarity with p38alpha than with the other isoforms. Both are sensitive to pyridinylimidazoles and share some common substrates such as MAPK activated protein kinase 2 (MK2) and the transcription factors ATF2, c-Fos and, ELK-1. p38beta is involved in regulating the activation of the cyclooxygenase-2 promoter and the expression of TGFbeta-induced alpha-smooth muscle cell actin. p38 kinases are mitogen-activated protein kinases (MAPKs), serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143383 [Multi-domain]  Cd Length: 343  Bit Score: 370.92  E-value: 3.68e-128
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIR-APTI 95
Cdd:cd07878  10 VWEVPERYQNLTPVGSGAYGSVCSAYDTRLRQKVAVKKLSrPFQSLIHARRTYRELRLLKHMKHENVIGLLDVFTpATSI 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  96 EQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD 175
Cdd:cd07878  90 ENFNEVYLVTNLMGADLNNIVKCQKLSDEHVQFLIYQLLRGLKYIHSAGIIHRDLKPSNVAVNEDCELRILDFGLARQAD 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 PDhdhtgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255
Cdd:cd07878 170 DE------MTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLKGKALFPGNDYIDQLKRIMEVVGTPSPEVLKKI 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 256 INLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEaPFKFDMEL 335
Cdd:cd07878 244 SSEHARKYIQSLPHMPQQDLKKIFRGANPLAIDLLEKMLVLDSDKRISASEALAHPYFSQYHDPEDEPEAE-PYDESPEN 322
                       330       340
                ....*....|....*....|.
gi 66932916 336 DDLPKEKLKELIFEETARFQP 356
Cdd:cd07878 323 KERTIEEWKELTYEEVSSFKP 343
STKc_TDY_MAPK cd07859
Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; ...
24-356 3.47e-121

Catalytic domain of the Serine/Threonine Kinases, Plant TDY Mitogen-Activated Protein Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Plant MAPKs are typed based on the conserved phosphorylation motif present in the activation loop, TEY and TDY. This subfamily represents the TDY subtype and is composed of Group D plant MAPKs including Arabidopsis thaliana MPK18 (AtMPK18), Oryza sativa Blast- and Wound-induced MAPK1 (OsBWMK1), OsWJUMK1 (Wound- and JA-Uninducible MAPK1), Zea mays MPK6, and the Medicago sativa TDY1 gene product. OsBWMK1 enhances resistance to pathogenic infections. It mediates stress-activated defense responses by activating a transcription factor that affects the expression of stress-related genes. AtMPK18 is involved in microtubule-related functions. In plants, MAPKs are associated with physiological, developmental, hormonal, and stress responses. Some plants show numerous gene duplications of MAPKs; Arabidopsis thaliana harbors at least 20 MAPKs, named AtMPK1-20 while Oryza sativa contains at least 17 MAPKs. Arabidopsis thaliana contains more TEY-type MAPKs than TDY-type, whereas the reverse is true for Oryza sativa. The TDY MAPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143364 [Multi-domain]  Cd Length: 338  Bit Score: 352.93  E-value: 3.47e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISP-FEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVY 102
Cdd:cd07859   1 RYKIQEVIGKGSYGVVCSAIDTHTGEKVAIKKINDvFEHVSDATRILREIKLLRLLRHPDIVEIKHIMLPPSRREFKDIY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHT 181
Cdd:cd07859  81 VVFELMESDLHQVIKANDdLTPEHHQFFLYQLLRALKYIHTANVFHRDLKPKNILANADCKLKICDFGLARVAFNDTPTA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLTEYVATRWYRAPEIM--LNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 259
Cdd:cd07859 161 IFWTDYVATRWYRAPELCgsFFSK-YTPAIDIWSIGCIFAEVLTGKPLFPGKNVVHQLDLITDLLGTPSPETISRVRNEK 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 260 ARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEAPFK--FDMELDD 337
Cdd:cd07859 240 ARRYLSSMRKKQPVPFSQKFPNADPLALRLLERLLAFDPKDRPTAEEALADPYFKGLAKVEREPSAQPITKleFEFERRR 319
                       330
                ....*....|....*....
gi 66932916 338 LPKEKLKELIFEETARFQP 356
Cdd:cd07859 320 LTKEDVRELIYREILEYHP 338
STKc_p38gamma cd07880
Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase ...
14-356 1.62e-118

Catalytic domain of the Serine/Threonine Kinase, p38gamma Mitogen-Activated Protein Kinase (also called MAPK12); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38gamma/MAPK12 is predominantly expressed in skeletal muscle. Unlike p38alpha and p38beta, p38gamma is insensitive to pyridinylimidazoles. It displays an antagonizing function compared to p38alpha. p38gamma inhibits, while p38alpha stimulates, c-Jun phosphorylation and AP-1 mediated transcription. p38gamma also plays a role in the signaling between Ras and the estrogen receptor and has been implicated to increase cell invasion and breast cancer progression. In Xenopus, p38gamma is critical in the meiotic maturation of oocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143385 [Multi-domain]  Cd Length: 343  Bit Score: 346.55  E-value: 1.62e-118
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRA 92
Cdd:cd07880   6 VNKTIWEVPDRYRDLKQVGSGAYGTVCSALDRRTGAKVAIKKLyRPFQSELFAKRAYRELRLLKHMKHENVIGLLDVFTP 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  93 P-TIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA 171
Cdd:cd07880  86 DlSLDRFHDFYLVMPFMGTDLGKLMKHEKLSEDRIQFLVYQMLKGLKYIHAAGIIHRDLKPGNLAVNEDCELKILDFGLA 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 172 RVADPDhdhtgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
Cdd:cd07880 166 RQTDSE------MTGYVVTRWYRAPEVILNWMHYTQTVDIWSVGCIMAEMLTGKPLFKGHDHLDQLMEIMKVTGTPSKEF 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 252 LNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEapfKF 331
Cdd:cd07880 240 VQKLQSEDAKNYVKKLPRFRKKDFRSLLPNANPLAVNVLEKMLVLDAESRITAAEALAHPYFEEFHDPEDETEAP---PY 316
                       330       340
                ....*....|....*....|....*..
gi 66932916 332 DMELD--DLPKEKLKELIFEETARFQP 356
Cdd:cd07880 317 DDSFDevDQSLEEWKRLTFTEILSFQP 343
STKc_MAPK4_6 cd07854
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also ...
19-351 2.18e-117

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinases 4 (also called ERK4) and 6 (also called ERK3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK4 (also called ERK4 or p63MAPK) and MAPK6 (also called ERK3 or p97MAPK) are atypical MAPKs that are not regulated by MAPK kinases. MAPK6 is expressed ubiquitously with highest amounts in brain and skeletal muscle. It may be involved in the control of cell differentiation by negatively regulating cell cycle progression in certain conditions. It may also play a role in glucose-induced insulin secretion. MAPK6 and MAPK4 cooperate to regulate the activity of MAPK-activated protein kinase 5 (MK5), leading to its relocation to the cytoplasm and exclusion from the nucleus. The MAPK6/MK5 and MAPK4/MK5 pathways may play critical roles in embryonic and post-natal development. MAPKs are important mediators of cellular responses to extracellular signals. The MAPK4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143359 [Multi-domain]  Cd Length: 342  Bit Score: 343.68  E-value: 2.18e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTyCQRTLREIKILLRFRHENIIGINDII---RAPTI 95
Cdd:cd07854   1 FDLGSRYMDLRPLGCGSNGLVFSAVDSDCDKRVAVKKIVLTDPQS-VKHALREIKIIRRLDHDNIVKVYEVLgpsGSDLT 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  96 EQMKD------VYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT-TCDLKICDF 168
Cdd:cd07854  80 EDVGSltelnsVYIVQEYMETDLANVLEQGPLSEEHARLFMYQLLRGLKYIHSANVLHRDLKPANVFINTeDLVLKIGDF 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 169 GLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 248
Cdd:cd07854 160 GLARIVDPHYSHKGYLSEGLVTKWYRSPRLLLSPNNYTKAIDMWAAGCIFAEMLTGKPLFAGAHELEQMQLILESVPVVR 239
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 249 QEDLNCIINL---KARNYlLSLPHKnkvPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIA 325
Cdd:cd07854 240 EEDRNELLNVipsFVRND-GGEPRR---PLRDLLPGVNPEALDFLEQILTFNPMDRLTAEEALMHPYMSCYSCPFDEPVS 315
                       330       340
                ....*....|....*....|....*..
gi 66932916 326 EAPFKFDMELDD-LPKEKLKELIFEET 351
Cdd:cd07854 316 LHPFHIEDELDDiLLMTEIHSIIYNWD 342
STKc_p38delta cd07879
Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase ...
12-356 4.69e-112

Catalytic domain of the Serine/Threonine Kinase, p38delta Mitogen-Activated Protein Kinase (also called MAPK13); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p38delta/MAPK13 is found in skeletal muscle, heart, lung, testis, pancreas, and small intestine. It regulates microtubule function by phosphorylating Tau. It activates the c-jun promoter and plays a role in G2 cell cycle arrest. It also controls the degration of c-Myb, which is associated with myeloid leukemia and poor prognosis in colorectal cancer. p38delta is the main isoform involved in regulating the differentiation and apoptosis of keratinocytes. p38 kinases are MAPKs, serving as important mediators of cellular responses to extracellular signals. They are activated by the MAPK kinases MKK3 and MKK6, which in turn are activated by upstream MAPK kinase kinases including TAK1, ASK1, and MLK3, in response to cellular stresses or inflammatory cytokines. The p38delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143384 [Multi-domain]  Cd Length: 342  Bit Score: 329.94  E-value: 4.69e-112
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  12 EMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDI- 89
Cdd:cd07879   4 EEVNKTVWELPERYTSLKQVGSGAYGSVCSAIDKRTGEKVAIKKLSrPFQSEIFAKRAYRELTLLKHMQHENVIGLLDVf 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  90 IRAPTIEQMKDVYIVQDLMETDLYKLLKtQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 169
Cdd:cd07879  84 TSAVSGDEFQDFYLVMPYMQTDLQKIMG-HPLSEDKVQYLVYQMLCGLKYIHSAGIIHRDLKPGNLAVNEDCELKILDFG 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 170 LARVADPDhdhtgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 249
Cdd:cd07879 163 LARHADAE------MTGYVVTRWYRAPEVILNWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGP 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 250 EDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAEaPF 329
Cdd:cd07879 237 EFVQKLEDKAAKSYIKSLPKYPRKDFSTLFPKASPQAVDLLEKMLELDVDKRLTATEALEHPYFDSFRDADEETEQQ-PY 315
                       330       340
                ....*....|....*....|....*..
gi 66932916 330 KFDMELDDLPKEKLKELIFEETARFQP 356
Cdd:cd07879 316 DDSLENEKLSVDEWKKHIYKEVKSFSP 342
STKc_JNK cd07850
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the ...
24-350 1.57e-108

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. They are also essential regulators of physiological and pathological processes and are involved in the pathogenesis of several diseases such as diabetes, atherosclerosis, stroke, Parkinson's and Alzheimer's. Vetebrates harbor three different JNK genes (Jnk1, Jnk2, and Jnk3) that are alternatively spliced to produce at least 10 isoforms. JNKs are specifically activated by the MAPK kinases MKK4 and MKK7, which are in turn activated by upstream MAPK kinase kinases as a result of different stimuli including stresses such as ultraviolet (UV) irradiation, hyperosmolarity, heat shock, or cytokines. JNKs activate a large number of different substrates based on specific stimulus, cell type, and cellular condition, and may be implicated in seemingly contradictory functions. The JNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270840 [Multi-domain]  Cd Length: 337  Bit Score: 320.90  E-value: 1.57e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGI-NDIIRAPTIEQMKDV 101
Cdd:cd07850   1 RYQNLKPIGSGAQGIVCAAYDTVTGQNVAIKKLSrPFQNVTHAKRAYRELVLMKLVNHKNIIGLlNVFTPQKSLEEFQDV 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMETDLYKLLktqHLSNDH--ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpdhd 179
Cdd:cd07850  81 YLVMELMDANLCQVI---QMDLDHerMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG---- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 hTGFL-TEYVATRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNcIINL 258
Cdd:cd07850 154 -TSFMmTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMIRGTVLFPGTDHIDQWNKIIEQLGTPSDEFMS-RLQP 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 259 KARNYLLSLPHKNKVPWNRLFPN----ADS---------KALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSdEPIA 325
Cdd:cd07850 231 TVRNYVENRPKYAGYSFEELFPDvlfpPDSeehnklkasQARDLLSKMLVIDPEKRISVDDALQHPYINVWYDPS-EVEA 309
                       330       340
                ....*....|....*....|....*..
gi 66932916 326 EAPFKFDMELD--DLPKEKLKELIFEE 350
Cdd:cd07850 310 PPPAPYDHSIDerEHTVEEWKELIYKE 336
STKc_CMGC cd05118
Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
25-313 6.82e-107

Catalytic domain of CMGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The CMGC family consists of Cyclin-Dependent protein Kinases (CDKs), Mitogen-activated protein kinases (MAPKs) such as Extracellular signal-regulated kinase (ERKs), c-Jun N-terminal kinases (JNKs), and p38, and other kinases. CDKs belong to a large subfamily of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. MAPKs serve as important mediators of cellular responses to extracellular signals. They control critical cellular functions including differentiation, proliferation, migration, and apoptosis. They are also implicated in the pathogenesis of many diseases including multiple types of cancer, stroke, diabetes, and chronic inflammation. Other members of the CMGC family include casein kinase 2 (CK2), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK), Glycogen Synthase Kinase 3 (GSK3), among many others. The CMGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270688 [Multi-domain]  Cd Length: 249  Bit Score: 313.40  E-value: 6.82e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHqtYCQRTLREIKILLRFR----HENIIGINDIIRAPTieqMKD 100
Cdd:cd05118   1 YEVLRKIGEGAFGTVWLARDKVTGEKVAIKKIKNDFR--HPKAALREIKLLKHLNdvegHPNIVKLLDVFEHRG---GNH 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLMETDLYKLLKT--QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGLARVADPD 177
Cdd:cd05118  76 LCLVFELMGMNLYELIKDypRGLPLDLIKSYLYQLLQALDFLHSNGIIHRDLKPENILINLeLGQLKLADFGLARSFTSP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 hdhtgFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPsqedlnciin 257
Cdd:cd05118 156 -----PYTPYVATRWYRAPEVLLGAKPYGSSIDIWSLGCILAELLTGRPLFPGDSEVDQLAKIVRLLGTP---------- 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 258 lkarnyllslphknkvpwnrlfpnadsKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd05118 221 ---------------------------EALDLLSKMLKYDPAKRITASQALAHPYF 249
STKc_CDK_like cd07829
Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs ...
25-313 6.11e-104

Catalytic domain of Cyclin-Dependent protein Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. CDKs are partly regulated by their subcellular localization, which defines substrate phosphorylation and the resulting specific function. CDK1, CDK2, CDK4, and CDK6 have well-defined functions in the cell cycle, such as the regulation of the early G1 phase by CDK4 or CDK6, the G1/S phase transition by CDK2, or the entry of mitosis by CDK1. They also exhibit overlapping cyclin specificity and functions in certain conditions. Knockout mice with a single CDK deleted remain viable with specific phenotypes, showing that some CDKs can compensate for each other. For example, CDK4 can compensate for the loss of CDK6, however, double knockout mice with both CDK4 and CDK6 deleted die in utero. CDK8 and CDK9 are mainly involved in transcription while CDK5 is implicated in neuronal function. CDK7 plays essential roles in both the cell cycle as a CDK-Activating Kinase (CAK) and in transcription as a component of the general transcription factor TFIIH. The CDK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270823 [Multi-domain]  Cd Length: 282  Bit Score: 307.10  E-value: 6.11e-104
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIsPFEHQTY--CQRTLREIKILLRFRHENIIGINDIIRaptieQMKDVY 102
Cdd:cd07829   1 YEKLEKLGEGTYGVVYKAKDKKTGEIVALKKI-RLDNEEEgiPSTALREISLLKELKHPNIVKLLDVIH-----TENKLY 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLLKT--QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR---VADPD 177
Cdd:cd07829  75 LVFEYCDQDLKKYLDKrpGPLPPNLIKSIMYQLLRGLAYCHSHRILHRDLKPQNLLINRDGVLKLADFGLARafgIPLRT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HDHTgflteyVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 257
Cdd:cd07829 155 YTHE------VVTLWYRAPEILLGSKHYSTAVDIWSVGCIFAELITGKPLFPGDSEIDQLFKIFQILGTPTEESWPGVTK 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 258 LKarNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07829 229 LP--DYKPTFPKWPKNDLEKVLPRLDPEGIDLLSKMLQYNPAKRISAKEALKHPYF 282
STKc_NLK cd07853
Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer ...
31-359 1.26e-102

Catalytic domain of the Serine/Threonine Kinase, Nemo-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NLK is an atypical mitogen-activated protein kinase (MAPK) that is not regulated by a MAPK kinase. It functions downstream of the MAPK kinase kinase Tak1, which also plays a role in activating the JNK and p38 MAPKs. The Tak1/NLK pathways are regulated by Wnts, a family of secreted proteins that is critical in the control of asymmetric division and cell polarity. NLK can phosphorylate transcription factors from the TCF/LEF family, inhibiting their ability to activate the transcription of target genes. In prostate cancer cells, NLK is involved in regulating androgen receptor-mediated transcription and its expression is altered during cancer progression. MAPKs are important mediators of cellular responses to extracellular signals. The NLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173748 [Multi-domain]  Cd Length: 372  Bit Score: 307.06  E-value: 1.26e-102
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLME 109
Cdd:cd07853   8 IGYGAFGVVWSVTDPRDGKRVALKKMpNVFQNLVSCKRVFRELKMLCFFKHDNVLSALDILQPPHIDPFEEIYVVTELMQ 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPdhDHTGFLTEYV 188
Cdd:cd07853  88 SDLHKIIvSPQPLSSDHVKVFLYQILRGLKYLHSAGILHRDIKPGNLLVNSNCVLKICDFGLARVEEP--DESKHMTQEV 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 189 ATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINlKARNYLLSLP 268
Cdd:cd07853 166 VTQYYRAPEILMGSRHYTSAVDIWSVGCIFAELLGRRILFQAQSPIQQLDLITDLLGTPSLEAMRSACE-GARAHILRGP 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 269 HKNKVpWNRLF---PNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ--------------------YYDPSDEPIA 325
Cdd:cd07853 245 HKPPS-LPVLYtlsSQATHEAVHLLCRMLVFDPDKRISAADALAHPYLDEgrlryhtcmckccyttsggrVYTSDFEPSA 323
                       330       340       350
                ....*....|....*....|....*....|....
gi 66932916 326 EAPFKFDMELDDLPKEKLKELIFEETARFQPGYR 359
Cdd:cd07853 324 NPPFDDEYEKNLTSVRQVKEELHQFILEQQQGNR 357
S_TKc smart00220
Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or ...
25-313 1.45e-90

Serine/Threonine protein kinases, catalytic domain; Phosphotransferases. Serine or threonine-specific kinase subfamily.


Pssm-ID: 214567 [Multi-domain]  Cd Length: 254  Bit Score: 272.10  E-value: 1.45e-90
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916     25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTieqmkDVYIV 104
Cdd:smart00220   1 YEILEKLGEGSFGKVYLARDKKTGKLVAIKVIKKKKIKKDRERILREIKILKKLKHPNIVRLYDVFEDED-----KLYLV 75
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916    105 QDLMET-DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPdhdhTG 182
Cdd:smart00220  76 MEYCEGgDLFDLLKKRgRLSEDEARFYLRQILSALEYLHSKGIVHRDLKPENILLDEDGHVKLADFGLARQLDP----GE 151
                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916    183 FLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhylDQLNHILGILGSPsqedlnciinlkarn 262
Cdd:smart00220 152 KLTTFVGTPEYMAPEV-LLGKGYGKAVDIWSLGVILYELLTGKPPFPGD---DQLLELFKKIGKP--------------- 212
                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|.
gi 66932916    263 yllslphknKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:smart00220 213 ---------KPPFPPPEWDISPEAKDLIRKLLVKDPEKRLTAEEALQHPFF 254
STKc_CDK7 cd07841
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs ...
24-312 3.58e-89

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK7 plays essential roles in the cell cycle and in transcription. It associates with cyclin H and MAT1 and acts as a CDK-Activating Kinase (CAK) by phosphorylating and activating cell cycle CDKs (CDK1/2/4/6). In the brain, it activates CDK5. CDK7 is also a component of the general transcription factor TFIIH, which phosphorylates the C-terminal domain (CTD) of RNA polymerase II when it is bound with unphosphorylated DNA, as present in the pre-initiation complex. Following phosphorylation, the CTD dissociates from the DNA which allows transcription initiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270833 [Multi-domain]  Cd Length: 298  Bit Score: 270.21  E-value: 3.58e-89
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE--------HQTycqrTLREIKILLRFRHENIIGINDIIrapti 95
Cdd:cd07841   1 RYEKGKKLGEGTYAVVYKARDKETGRIVAIKKIKLGErkeakdgiNFT----ALREIKLLQELKHPNIIGLLDVF----- 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  96 EQMKDVYIVQDLMETDLYKLL--KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV 173
Cdd:cd07841  72 GHKSNINLVFEFMETDLEKVIkdKSIVLTPADIKSYMLMTLRGLEYLHSNWILHRDLKPNNLLIASDGVLKLADFGLARS 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 -ADPDhdhtGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDl 252
Cdd:cd07841 152 fGSPN----RKMTHQVVTRWYRAPELLFGARHYGVGVDMWSVGCIFAELLLRVPFLPGDSDIDQLGKIFEALGTPTEEN- 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 253 ncIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07841 227 --WPGVTSLPDYVEFKPFPPTPLKQIFPAASDDALDLLQRLLTLNPNKRITARQALEHPY 284
STKc_JNK2 cd07876
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the ...
14-350 1.04e-88

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK2 is expressed in every cell and tissue type. It is specifically translocated to the mitochondria during dopaminergic cell death. Specific substrates include the microtubule-associated proteins DCX and Tau, as well as TIF-IA which is involved in ribosomal RNA synthesis regulation. Mice deficient in Jnk2 show protection against arthritis, type 1 diabetes, atherosclerosis, abdominal aortic aneurysm, cardiac cell death, TNF-induced liver damage, and tumor growth, indicating that JNK2 may play roles in the pathogenesis of these diseases. Initially it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143381 [Multi-domain]  Cd Length: 359  Bit Score: 271.13  E-value: 1.04e-88
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  14 VRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIG-INDIIR 91
Cdd:cd07876  12 VADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSrPFQNQTHAKRAYRELVLLKCVNHKNIISlLNVFTP 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  92 APTIEQMKDVYIVQDLMETDLYKLLktqHLSNDH--ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 169
Cdd:cd07876  92 QKSLEEFQDVYLVMELMDANLCQVI---HMELDHerMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFG 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 170 LARVADPDHdhtgFLTEYVATRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 249
Cdd:cd07876 169 LARTACTNF----MMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGELVKGSVIFQGTDHIDQWNKVIEQLGTPSA 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 250 EDLNCIINlKARNYLLSLPHKNKVPWNRLFPN------------ADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYY 317
Cdd:cd07876 244 EFMNRLQP-TVRNYVENRPQYPGISFEELFPDwifpseserdklKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWY 322
                       330       340       350
                ....*....|....*....|....*....|....*
gi 66932916 318 DPSdEPIAEAPFKFDMELDDLPK--EKLKELIFEE 350
Cdd:cd07876 323 DPA-EAEAPPPQIYDAQLEEREHaiEEWKELIYKE 356
STKc_MAK_like cd07830
Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs ...
25-313 2.19e-87

Catalytic domain of Male germ cell-Associated Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of human MAK and MAK-related kinase (MRK), Saccharomyces cerevisiae Ime2p, Schizosaccharomyces pombe Mei4-dependent protein 3 (Mde3) and Pit1, Caenorhabditis elegans dyf-5, Arabidopsis thaliana MHK, and similar proteins. These proteins play important roles during meiosis. MAK is highly expressed in testicular cells specifically in the meiotic phase, but is not essential for spermatogenesis and fertility. It functions as a coactivator of the androgen receptor in prostate cells. MRK, also called Intestinal Cell Kinase (ICK), is expressed ubiquitously, with highest expression in the ovary and uterus. A missense mutation in MRK causes endocrine-cerebro-osteodysplasia, suggesting that this protein plays an important role in the development of many organs. MAK and MRK may be involved in regulating cell cycle and cell fate. Ime2p is a meiosis-specific kinase that is important during meiotic initiation and during the later stages of meiosis. Mde3 functions downstream of the transcription factor Mei-4 which is essential for meiotic prophase I. The MAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270824 [Multi-domain]  Cd Length: 283  Bit Score: 264.78  E-value: 2.19e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKK-ISPFEHQTYCQRtLREIKILLRF-RHENIIGINDIIRaptieQMKDVY 102
Cdd:cd07830   1 YKVIKQLGDGTFGSVYLARNKETGELVAIKKmKKKFYSWEECMN-LREVKSLRKLnEHPNIVKLKEVFR-----ENDELY 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLLKTQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR--VADPD 177
Cdd:cd07830  75 FVFEYMEGNLYQLMKDRkgkPFSESVIRSIIYQILQGLAHIHKHGFFHRDLKPENLLVSGPEVVKIADFGLAReiRSRPP 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HdhtgflTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 257
Cdd:cd07830 155 Y------TDYVSTRWYRAPEILLRSTSYSSPVDIWALGCIMAELYTLRPLFPGSSEIDQLYKICSVLGTPTKQDWPEGYK 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 258 LkARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07830 229 L-ASKLGFRFPQFAPTSLHQLIPNASPEAIDLIKDMLRWDPKKRPTASQALQHPYF 283
STKc_GSK3 cd14137
The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze ...
21-312 4.42e-87

The catalytic domain of the Serine/Threonine Kinase, Glycogen Synthase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GSK3 is a mutifunctional kinase involved in many cellular processes including cell division, proliferation, differentiation, adhesion, and apoptosis. In plants, GSK3 plays a role in the response to osmotic stress. In Caenorhabditis elegans, it plays a role in regulating normal oocyte-to-embryo transition and response to oxidative stress. In Chlamydomonas reinhardtii, GSK3 regulates flagellar length and assembly. In mammals, there are two isoforms, GSK3alpha and GSK3beta, which show both distinct and redundant functions. The two isoforms differ mainly in their N-termini. They are both involved in axon formation and in Wnt signaling.They play distinct roles in cardiogenesis, with GSKalpha being essential in cardiomyocyte survival, and GSKbeta regulating heart positioning and left-right symmetry. GSK3beta was first identified as a regulator of glycogen synthesis, but has since been determined to play other roles. It regulates the degradation of beta-catenin and IkB. Beta-catenin is the main effector of Wnt, which is involved in normal haematopoiesis and stem cell function. IkB is a central inhibitor of NF-kB, which is critical in maintaining leukemic cell growth. GSK3beta is enriched in the brain and is involved in regulating neuronal signaling pathways. It is implicated in the pathogenesis of many diseases including Type II diabetes, obesity, mood disorders, Alzheimer's disease, osteoporosis, and some types of cancer, among others. The GSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271039 [Multi-domain]  Cd Length: 293  Bit Score: 264.36  E-value: 4.42e-87
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  21 VGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIspFEHQTYCQRtlrEIKILLRFRHENIIGINDIIRAPTiEQMKD 100
Cdd:cd14137   2 VEISYTIEKVIGSGSFGVVYQAKLLETGEVVAIKKV--LQDKRYKNR---ELQIMRRLKHPNIVKLKYFFYSSG-EKKDE 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VY--IVQDLMETDLYKLLKT-----QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLAR 172
Cdd:cd14137  76 VYlnLVMEYMPETLYRVIRHysknkQTIPIIYVKLYSYQLFRGLAYLHSLGICHRDIKPQNLLVDpETGVLKLCDFGSAK 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 VADPDHDHTgfltEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 252
Cdd:cd14137 156 RLVPGEPNV----SYICSRYYRAPELIFGATDYTTAIDIWSAGCVLAELLLGQPLFPGESSVDQLVEIIKVLGTPTREQI 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 253 NCiINLKARNYLlsLPHKNKVPWNRLFPN-ADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14137 232 KA-MNPNYTEFK--FPQIKPHPWEKVFPKrTPPDAIDLLSKILVYNPSKRLTALEALAHPF 289
STKc_JNK3 cd07874
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the ...
19-350 1.34e-86

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK3 is expressed primarily in the brain, and to a lesser extent in the heart and testis. Mice deficient in JNK3 are protected against kainic acid-induced seizures, stroke, sciatic axotomy neural death, and neuronal death due to NGF deprivation, oxidative stress, or exposure to beta-amyloid peptide. This suggests that JNK3 may play roles in the pathogenesis of these diseases. JNKs are mitogen-activated protein kinases (MAPKs) that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143379 [Multi-domain]  Cd Length: 355  Bit Score: 265.41  E-value: 1.34e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGI-NDIIRAPTIE 96
Cdd:cd07874  13 FTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSrPFQNQTHAKRAYRELVLMKCVNHKNIISLlNVFTPQKSLE 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 QMKDVYIVQDLMETDLYKLLKTQhLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADp 176
Cdd:cd07874  93 EFQDVYLVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG- 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 dhdhTGF-LTEYVATRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNcI 255
Cdd:cd07874 171 ----TSFmMTPYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMK-K 244
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 256 INLKARNYLLSLPHKNKVPWNRLFPNA------------DSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSdEP 323
Cdd:cd07874 245 LQPTVRNYVENRPKYAGLTFPKLFPDSlfpadsehnklkASQARDLLSKMLVIDPAKRISVDEALQHPYINVWYDPA-EV 323
                       330       340
                ....*....|....*....|....*....
gi 66932916 324 IAEAPFKFDMELDDLPK--EKLKELIFEE 350
Cdd:cd07874 324 EAPPPQIYDKQLDEREHtiEEWKELIYKE 352
STKc_CDK9_like cd07840
Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs ...
25-312 8.02e-86

Catalytic domain of Cyclin-Dependent protein Kinase 9-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK9 and CDK12 from higher eukaryotes, yeast BUR1, C-type plant CDKs (CdkC), and similar proteins. CDK9, BUR1, and CdkC are functionally equivalent. They act as a kinase for the C-terminal domain of RNA polymerase II and participate in regulating mutliple steps of gene expression including transcription elongation and RNA processing. CDK9 and CdkC associate with T-type cyclins while BUR1 associates with the cyclin BUR2. CDK12 is a unique CDK that contains an arginine/serine-rich (RS) domain, which is predominantly found in splicing factors. CDK12 interacts with cyclins L1 and L2, and participates in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270832 [Multi-domain]  Cd Length: 291  Bit Score: 261.34  E-value: 8.02e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPF-EHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMK-DVY 102
Cdd:cd07840   1 YEKIAQIGEGTYGQVYKARNKKTGELVALKKIRMEnEKEGFPITAIREIKLLQKLDHPNVVRLKEIVTSKGSAKYKgSIY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLL--KTQHLSNDHI-CYFlYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHD 179
Cdd:cd07840  81 MVFEYMDHDLTGLLdnPEVKFTESQIkCYM-KQLLEGLQYLHSNGILHRDIKGSNILINNDGVLKLADFGLARPYTKENN 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 htGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 259
Cdd:cd07840 160 --ADYTNRVITLWYRPPELLLGATRYGPEVDMWSVGCILAELFTGKPIFQGKTELEQLEKIFELCGSPTEENWPGVSDLP 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 260 arNYLLSLPHKNKVpwNRL---FPNA-DSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07840 238 --WFENLKPKKPYK--RRLrevFKNViDPSALDLLDKLLTLDPKKRISADQALQHEY 290
STKc_CCRK cd07832
Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the ...
24-313 7.38e-85

Catalytic domain of the Serine/Threonine Kinase, Cell Cycle-Related Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CCRK was previously called p42. It is a Cyclin-Dependent Kinase (CDK)-Activating Kinase (CAK) which is essential for the activation of CDK2. It is indispensable for cell growth and has been implicated in the progression of glioblastoma multiforme. In the heart, a splice variant of CCRK with a different C-terminal half is expressed; this variant promotes cardiac cell growth and survival and is significantly down-regulated during the development of heart failure. The CCRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270826 [Multi-domain]  Cd Length: 287  Bit Score: 258.80  E-value: 7.38e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFR-HENIIGINDIIRAPTieqmkDV 101
Cdd:cd07832   1 RYKILGRIGEGAHGIVFKAKDRETGETVALKKVaLRKLEGGIPNQALREIKALQACQgHPYVVKLRDVFPHGT-----GF 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMETDLYKLLKT--QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHD 179
Cdd:cd07832  76 VLVFEYMLSSLSEVLRDeeRPLTEAQVKRYMRMLLKGVAYMHANRIMHRDLKPANLLISSTGVLKIADFGLARLFSEEDP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 HTgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 259
Cdd:cd07832 156 RL--YSHQVATRWYRAPELLYGSRKYDEGVDLWAVGCIFAELLNGSPLFPGENDIEQLAIVLRTLGTPNEKTWPELTSLP 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 260 ARNYlLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07832 234 DYNK-ITFPESKGIRLEEIFPDCSPEAIDLLKGLLVYNPKKRLSAEEALRHPYF 286
STKc_JNK1 cd07875
Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the ...
19-350 2.24e-83

Catalytic domain of the Serine/Threonine Kinase, c-Jun N-terminal Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. JNK1 is expressed in every cell and tissue type. It specifically binds with JAMP (JNK1-associated membrane protein), which regulates the duration of JNK1 activity in response to stimuli. Specific JNK1 substrates include Itch and SG10, which are implicated in Th2 responses and airway inflammation, and microtubule dynamics and axodendritic length, respectively. Mice deficient in JNK1 are protected against arthritis, obesity, type 2 diabetes, cardiac cell death, and non-alcoholic liver disease, suggesting that JNK1 may play roles in the pathogenesis of these diseases. Initially, it was thought that JNK1 and JNK2 were functionally redundant as mice deficient in either genes could survive but disruption of both genes resulted in lethality. However, recent studies have shown that JNK1 and JNK2 perform distinct functions through specific binding partners and substrates. JNKs are mitogen-activated protein kinases that are involved in many stress-activated responses including those during inflammation, neurodegeneration, apoptosis, and persistent pain sensitization, among others. The JNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143380 [Multi-domain]  Cd Length: 364  Bit Score: 257.67  E-value: 2.24e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGI-NDIIRAPTIE 96
Cdd:cd07875  20 FTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSrPFQNQTHAKRAYRELVLMKCVNHKNIIGLlNVFTPQKSLE 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 QMKDVYIVQDLMETDLYKLLKTQhLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADp 176
Cdd:cd07875 100 EFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAG- 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 dhdhTGFLTE-YVATRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNcI 255
Cdd:cd07875 178 ----TSFMMTpYVVTRYYRAPEVIL-GMGYKENVDIWSVGCIMGEMIKGGVLFPGTDHIDQWNKVIEQLGTPCPEFMK-K 251
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 256 INLKARNYLLSLPHKNKVPWNRLFPN----AD--------SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSdEP 323
Cdd:cd07875 252 LQPTVRTYVENRPKYAGYSFEKLFPDvlfpADsehnklkaSQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPS-EA 330
                       330       340
                ....*....|....*....|....*....
gi 66932916 324 IAEAPFKFDMELDDLPK--EKLKELIFEE 350
Cdd:cd07875 331 EAPPPKIPDKQLDEREHtiEEWKELIYKE 359
STKc_CDC2L1 cd07843
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze ...
25-312 6.65e-82

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 2-like 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L1, also called PITSLRE, exists in different isoforms which are named using the alias CDK11(p). The CDC2L1 gene produces two protein products, CDK11(p110) and CDK11(p58). CDC2L1 is also represented by the caspase-processed CDK11(p46). CDK11(p110), the major isoform, associates with cyclin L and is expressed throughout the cell cycle. It is involved in RNA processing and the regulation of transcription. CDK11(p58) associates with cyclin D3 and is expressed during the G2/M phase of the cell cycle. It plays roles in spindle morphogenesis, centrosome maturation, sister chromatid cohesion, and the completion of mitosis. CDK11(p46) is formed from the larger isoforms by caspases during TNFalpha- and Fas-induced apoptosis. It functions as a downstream effector kinase in apoptotic signaling pathways and interacts with eukaryotic initiation factor 3f (eIF3f), p21-activated kinase (PAK1), and Ran-binding protein (RanBPM). CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173741 [Multi-domain]  Cd Length: 293  Bit Score: 251.37  E-value: 6.65e-82
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQ-----TYcqrtLREIKILLRFRHENIIGINDIIRAPTieqMK 99
Cdd:cd07843   7 YEKLNRIEEGTYGVVYRARDKKTGEIVALKKLKMEKEKegfpiTS----LREINILLKLQHPNIVTVKEVVVGSN---LD 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 DVYIVQDLMETDLYKLLKT--QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADP 176
Cdd:cd07843  80 KIYMVMEYVEHDLKSLMETmkQPFLQSEVKCLMLQLLSGVAHLHDNWILHRDLKTSNLLLNNRGILKICDFGLAReYGSP 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 DHDhtgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
Cdd:cd07843 160 LKP----YTQLVVTLWYRAPELLLGAKEYSTAIDMWSVGCIFAELLTKKPLFPGKSEIDQLNKIFKLLGTPTEKIWPGFS 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 257 NLKARNYLlslpHKNKVPWNRL---FPNA--DSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07843 236 ELPGAKKK----TFTKYPYNQLrkkFPALslSDNGFDLLNRLLTYDPAKRISAEDALKHPY 292
STKc_CDK1_CdkB_like cd07835
Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of ...
25-313 1.16e-76

Catalytic domain of Cyclin-Dependent protein Kinase 1-like Serine/Threonine Kinases and of Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK, CDK2, and CDK3. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression while the CDK1/cyclin B complex is critical for G2 to M phase transition. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. Studies in knockout mice revealed that CDK1 can compensate for the loss of the cdk2 gene as it can also bind cyclin E and drive G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270829 [Multi-domain]  Cd Length: 283  Bit Score: 237.57  E-value: 1.16e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQT--YCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVY 102
Cdd:cd07835   1 YQKLEKIGEGTYGVVYKARDKLTGEIVALKKIR-LETEDegVPSTAIREISLLKELNHPNIVRLLDVV-----HSENKLY 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVadpdhd 179
Cdd:cd07835  75 LVFEFLDLDLKKYMDSsplTGLDPPLIKSYLYQLLQGIAFCHSHRVLHRDLKPQNLLIDTEGALKLADFGLARA------ 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 htgF------LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 253
Cdd:cd07835 149 ---FgvpvrtYTHEVVTLWYRAPEILLGSKHYSTPVDIWSVGCIFAEMVTRRPLFPGDSEIDQLFRIFRTLGTPDEDVWP 225
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 254 CIINLKarNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07835 226 GVTSLP--DYKPTFPKWARQDLSKVVPSLDEDGLDLLSQMLVYDPAKRISAKAALQHPYF 283
STKc_CDK4_6_like cd07838
Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; ...
25-313 3.80e-76

Catalytic domain of Cyclin-Dependent protein Kinase 4 and 6-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 and CDK6 partner with D-type cyclins to regulate the early G1 phase of the cell cycle. They are the first kinases activated by mitogenic signals to release cells from the G0 arrested state. CDK4 and CDK6 are both expressed ubiquitously, associate with all three D cyclins (D1, D2 and D3), and phosphorylate the retinoblastoma (pRb) protein. They are also regulated by the INK4 family of inhibitors which associate with either the CDK alone or the CDK/cyclin complex. CDK4 and CDK6 show differences in subcellular localization, sensitivity to some inhibitors, timing in activation, tumor selectivity, and possibly substrate profiles. Although CDK4 and CDK6 seem to show some redundancy, they also have discrete, nonoverlapping functions. CDK6 plays an important role in cell differentiation. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4/6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270831 [Multi-domain]  Cd Length: 287  Bit Score: 236.40  E-value: 3.80e-76
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREI---KILLRFRHENIIGINDIIRAPTIEQMKD 100
Cdd:cd07838   1 YEEVAEIGEGAYGTVYKARDLQDGRFVALKKVRvPLSEEGIPLSTIREIallKQLESFEHPNVVRLLDVCHGPRTDRELK 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLMETDLYKLLK---TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVadpd 177
Cdd:cd07838  81 LTLVFEHVDQDLATYLDkcpKPGLPPETIKDLMRQLLRGLDFLHSHRIVHRDLKPQNILVTSDGQVKLADFGLARI---- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HDHTGFLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 257
Cdd:cd07838 157 YSFEMALTSVVVTLWYRAPEVLLQSS-YATPVDMWSVGCIFAELFNRRPLFRGSSEADQLGKIFDVIGLPSEEEWPRNSA 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 258 LKARNYllslPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07838 236 LPRSSF----PSYTPRPFKSFVPEIDEEGLDLLKKMLTFNPHKRISAFEALQHPYF 287
STKc_BUR1 cd07866
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), ...
24-312 1.25e-74

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase (CDK), Bypass UAS Requirement 1, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BUR1, also called SGV1, is a yeast CDK that is functionally equivalent to mammalian CDK9. It associates with the cyclin BUR2. BUR genes were orginally identified in a genetic screen as factors involved in general transcription. The BUR1/BUR2 complex phosphorylates the C-terminal domain of RNA polymerase II. In addition, this complex regulates histone modification by phosporylating Rad6 and mediating the association of the Paf1 complex with chromatin. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The BUR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270849 [Multi-domain]  Cd Length: 311  Bit Score: 233.36  E-value: 1.25e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPF-EHQTYCQRTLREIKILLRFRHENIIGINDII--RAPTI-EQMK 99
Cdd:cd07866   9 DYEILGKLGEGTFGEVYKARQIKTGRVVALKKILMHnEKDGFPITALREIKILKKLKHPNVVPLIDMAveRPDKSkRKRG 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 DVYIVQDLMETDLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD-- 175
Cdd:cd07866  89 SVYMVTPYMDHDLSGLLENPsvKLTESQIKCYMLQLLEGINYLHENHILHRDIKAANILIDNQGILKIADFGLARPYDgp 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 ---PDHDHTGFLTEY---VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 249
Cdd:cd07866 169 ppnPKGGGGGGTRKYtnlVVTRWYRPPELLLGERRYTTAVDIWGIGCVFAEMFTRRPILQGKSDIDQLHLIFKLCGTPTE 248
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916 250 EDLNCIINLK-ARNYLLSLPHKNKVpwNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07866 249 ETWPGWRSLPgCEGVHSFTNYPRTL--EERFGKLGPEGLDLLSKLLSLDPYKRLTASDALEHPY 310
STKc_CDKL cd07833
Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs ...
24-313 3.82e-74

Catalytic domain of Cyclin-Dependent protein Kinase Like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDKL1-5 and similar proteins. Some CDKLs, like CDKL1 and CDKL3, may be implicated in transformation and others, like CDKL3 and CDKL5, are associated with mental retardation when impaired. CDKL2 plays a role in learning and memory. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270827 [Multi-domain]  Cd Length: 288  Bit Score: 231.44  E-value: 3.82e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRT-LREIKILLRFRHENIIGINDIIRaptieQMKDVY 102
Cdd:cd07833   2 KYEVLGVVGEGAYGVVLKCRNKATGEIVAIKKFKESEDDEDVKKTaLREVKVLRQLRHENIVNLKEAFR-----RKGRLY 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHD 179
Cdd:cd07833  77 LVFEYVERTLLELLEASPggLPPDAVRSYIWQLLQAIAYCHSHNIIHRDIKPENILVSESGVLKLCDFGFARaLTARPAS 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 HtgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILG--SPSQEDLnciIN 257
Cdd:cd07833 157 P---LTDYVATRWYRAPELLVGDTNYGKPVDVWAIGCIMAELLDGEPLFPGDSDIDQLYLIQKCLGplPPSHQEL---FS 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 258 LKARNYLLSLPH-KNKVPWNRLFPNA-DSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07833 231 SNPRFAGVAFPEpSQPESLERRYPGKvSSPALDFLKACLRMDPKERLTCDELLQHPYF 288
STKc_CDK10 cd07845
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs ...
25-312 6.25e-74

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK10, also called PISSLRE, is essential for cell growth and proliferation, and acts through the G2/M phase of the cell cycle. CDK10 has also been identified as an important factor in endocrine therapy resistance in breast cancer. CDK10 silencing increases the transcription of c-RAF and the activation of the p42/p44 MAPK pathway, which leads to antiestrogen resistance. Patients who express low levels of CDK10 relapse early on tamoxifen. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK10 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173742 [Multi-domain]  Cd Length: 309  Bit Score: 231.49  E-value: 6.25e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIrapTIEQMKDVYI 103
Cdd:cd07845   9 FEKLNRIGEGTYGIVYRARDTTSGEIVALKKVRmDNERDGIPISSLREITLLLNLRHPNIVELKEVV---VGKHLDSIFL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLK--TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV-ADPDHDh 180
Cdd:cd07845  86 VMEYCEQDLASLLDnmPTPFSESQVKCLMLQLLRGLQYLHENFIIHRDLKVSNLLLTDKGCLKIADFGLARTyGLPAKP- 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 tgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK- 259
Cdd:cd07845 165 ---MTPKVVTLWYRAPELLLGCTTYTTAIDMWAVGCILAELLAHKPLLPGKSEIEQLDLIIQLLGTPNESIWPGFSDLPl 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 260 ARNYllSLPHKnkvPWNRL---FPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07845 242 VGKF--TLPKQ---PYNNLkhkFPWLSEAGLRLLNFLLMYDPKKRATAEEALESSY 292
STKc_CDK8_like cd07842
Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs ...
24-312 4.83e-70

Catalytic domain of Cyclin-Dependent protein Kinase 8-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of CDK8, CDC2L6, and similar proteins. CDK8 functions as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II-dependent transcription. CDC2L6 also associates with Mediator in complexes lacking CDK8. In VP16-dependent transcriptional activation, CDK8 and CDC2L6 exerts opposing effects by positive and negative regulation, respectively, in similar conditions. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270834 [Multi-domain]  Cd Length: 316  Bit Score: 221.78  E-value: 4.83e-70
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAY--DNVNKVRVAIKKISPFEHQT--YCQRTLREIKILLRFRHENIIGINDIIraptIEQM- 98
Cdd:cd07842   1 KYEIEGCIGRGTYGRVYKAKrkNGKDGKEYAIKKFKGDKEQYtgISQSACREIALLRELKHENVVSLVEVF----LEHAd 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLMETDLYKLLK------TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD----LKICDF 168
Cdd:cd07842  77 KSVYLLFDYAEHDLWQIIKfhrqakRVSIPPSMVKSLLWQILNGIHYLHSNWVLHRDLKPANILVMGEGPergvVKIGDL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 169 GLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK---------HYLDQLNH 239
Cdd:cd07842 157 GLARLFNAPLKPLADLDPVVVTIWYRAPELLLGARHYTKAIDIWAIGCIFAELLTLEPIFKGReakikksnpFQRDQLER 236
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 240 ILGILGSPSQEDLNCIIN------LKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07842 237 IFEVLGTPTEKDWPDIKKmpeydtLKSDTKASTYPNSLLAKWMHKHKKPDSQGFDLLRKLLEYDPTKRITAEEALEHPY 315
STKc_Pho85 cd07836
Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; ...
25-312 1.33e-69

Catalytic domain of the Serine/Threonine Kinase, Fungal Cyclin-Dependent protein Kinase Pho85; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Pho85 is a multifunctional CDK in yeast. It is regulated by 10 different cyclins (Pcls) and plays a role in G1 progression, cell polarity, phosphate and glycogen metabolism, gene expression, and in signaling changes in the environment. It is not essential for yeast viability and is the functional homolog of mammalian CDK5, which plays a role in central nervous system development. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The Pho85 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143341 [Multi-domain]  Cd Length: 284  Bit Score: 219.66  E-value: 1.33e-69
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTieqmkDVYIV 104
Cdd:cd07836   2 FKQLEKLGEGTYATVYKGRNRTTGEIVALKEIHLDAEEGTPSTAIREISLMKELKHENIVRLHDVIHTEN-----KLMLV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETDLYKLLKTQ----HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHD 179
Cdd:cd07836  77 FEYMDKDLKKYMDTHgvrgALDPNTVKSFTYQLLKGIAFCHENRVLHRDLKPQNLLINKRGELKLADFGLARaFGIPVNT 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 htgFLTEyVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLK 259
Cdd:cd07836 157 ---FSNE-VVTLWYRAPDVLLGSRTYSTSIDIWSVGCIMAEMITGRPLFPGTNNEDQLLKIFRIMGTPTESTWPGISQLP 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 260 arNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07836 233 --EYKPTFPRYPPQDLQQLFPHADPLGIDLLHRLLQLNPELRISAHDALQHPW 283
PTZ00024 PTZ00024
cyclin-dependent protein kinase; Provisional
19-331 1.58e-69

cyclin-dependent protein kinase; Provisional


Pssm-ID: 240233 [Multi-domain]  Cd Length: 335  Bit Score: 221.17  E-value: 1.58e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   19 FDVGPRYTNL-SYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQR-------------TLREIKILLRFRHENII 84
Cdd:PTZ00024   4 FSISERYIQKgAHLGEGTYGKVEKAYDTLTGKIVAIKKVKIIEISNDVTKdrqlvgmcgihftTLRELKIMNEIKHENIM 83
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   85 GINDIIraptIEQmKDVYIVQDLMETDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL 163
Cdd:PTZ00024  84 GLVDVY----VEG-DFINLVMDIMASDLKKVVDRKiRLTESQVKCILLQILNGLNVLHKWYFMHRDLSPANIFINSKGIC 158
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  164 KICDFGLAR--VADPDHDHTGF---------LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH 232
Cdd:PTZ00024 159 KIADFGLARryGYPPYSDTLSKdetmqrreeMTSKVVTLWYRAPELLMGAEKYHFAVDMWSVGCIFAELLTGKPLFPGEN 238
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  233 YLDQLNHILGILGSPSQEDLNciinlKARNYLLSLP--HKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAH 310
Cdd:PTZ00024 239 EIDQLGRIFELLGTPNEDNWP-----QAKKLPLYTEftPRKPKDLKTIFPNASDDAIDLLQSLLKLNPLERISAKEALKH 313
                        330       340
                 ....*....|....*....|.
gi 66932916  311 PYLEQYYDPSDepIAEAPFKF 331
Cdd:PTZ00024 314 EYFKSDPLPCD--PSQLPFNF 332
STKc_PCTAIRE_like cd07844
Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
25-313 8.99e-67

Catalytic domain of PCTAIRE-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-like proteins show unusual expression patterns with high levels in post-mitotic tissues, suggesting that they may be involved in regulating post-mitotic cellular events. They share sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The association of PCTAIRE-like proteins with cyclins has not been widely studied, although PFTAIRE-1 has been shown to function as a CDK which is regulated by cyclin D3 as well as the membrane-associated cyclin Y. The PCTAIRE-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270835 [Multi-domain]  Cd Length: 286  Bit Score: 212.24  E-value: 8.99e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYCQRT-LREIKILLRFRHENIIGINDIIRAPtieqmKDVYI 103
Cdd:cd07844   2 YKKLDKLGEGSYATVYKGRSKLTGQLVALKEIR-LEHEEGAPFTaIREASLLKDLKHANIVTLHDIIHTK-----KTLTL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLKtQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD-PDHD 179
Cdd:cd07844  76 VFEYLDTDLKQYMD-DCgggLSMHNVRLFLFQLLRGLAYCHQRRVLHRDLKPQNLLISERGELKLADFGLARAKSvPSKT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 HtgflTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG-KHYLDQLNHILGILGSPSQEDLNCII-N 257
Cdd:cd07844 155 Y----SNEVVTLWYRPPDVLLGSTEYSTSLDMWGVGCIFYEMATGRPLFPGsTDVEDQLHKIFRVLGTPTEETWPGVSsN 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 258 LKARNYllSLPHKNKVPWNRLFPNAD--SKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07844 231 PEFKPY--SFPFYPPRPLINHAPRLDriPHGEELALKFLQYEPKKRISAAEAMKHPYF 286
STKc_CDK12 cd07864
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs ...
25-313 3.72e-66

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 12; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK12 is also called Cdc2-related protein kinase 7 (CRK7) or Cdc2-related kinase arginine/serine-rich (CrkRS). It is a unique CDK that contains an RS domain, which is predominantly found in splicing factors. CDK12 is widely expressed in tissues. It interacts with cyclins L1 and L2, and plays roles in regulating transcription and alternative splicing. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK12 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270847 [Multi-domain]  Cd Length: 302  Bit Score: 211.20  E-value: 3.72e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDII--RAPTIEQMKD- 100
Cdd:cd07864   9 FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRlDNEKEGFPITAIREIKILRQLNHRSVVNLKEIVtdKQDALDFKKDk 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 --VYIVQDLMETDLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADP 176
Cdd:cd07864  89 gaFYLVFEYMDHDLMGLLESGlvHFSEDHIKSFMKQLLEGLNYCHKKNFLHRDIKCSNILLNNKGQIKLADFGLARLYNS 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 DHDHTgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
Cdd:cd07864 169 EESRP--YTNKVITLWYRPPELLLGEERYGPAIDVWSCGCILGELFTKKPIFQANQELAQLELISRLCGSPCPAVWPDVI 246
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 257 NLKARNYLlslphKNKVPWNRL----FPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07864 247 KLPYFNTM-----KPKKQYRRRlreeFSFIPTPALDLLDHMLTLDPSKRCTAEQALNSPWL 302
STKc_CDK2_3 cd07860
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; ...
31-312 5.29e-66

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK2 is regulated by cyclin E or cyclin A. Upon activation by cyclin E, it phosphorylates the retinoblastoma (pRb) protein which activates E2F mediated transcription and allows cells to move into S phase. The CDK2/cyclin A complex plays a role in regulating DNA replication. CDK2, together with CDK4, also regulates embryonic cell proliferation. Despite these important roles, mice deleted for the cdk2 gene are viable and normal except for being sterile. This may be due to compensation provided by CDK1 (also called Cdc2), which can also bind cyclin E and drive the G1 to S phase transition. CDK3 is regulated by cyclin C and it phosphorylates pRB specifically during the G0/G1 transition. This phosphorylation is required for cells to exit G0 efficiently and enter the G1 phase. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270844 [Multi-domain]  Cd Length: 284  Bit Score: 210.44  E-value: 5.29e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPtieqmKDVYIVQDLME 109
Cdd:cd07860   8 IGEGTYGVVYKARNKLTGEVVALKKIRlDTETEGVPSTAIREISLLKELNHPNIVKLLDVIHTE-----NKLYLVFEFLH 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV-ADPDHDHTgflt 185
Cdd:cd07860  83 QDLKKFMDAsalTGIPLPLIKSYLFQLLQGLAFCHSHRVLHRDLKPQNLLINTEGAIKLADFGLARAfGVPVRTYT---- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 EYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKarNYLL 265
Cdd:cd07860 159 HEVVTLWYRAPEILLGCKYYSTAVDIWSLGCIFAEMVTRRALFPGDSEIDQLFRIFRTLGTPDEVVWPGVTSMP--DYKP 236
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 266 SLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07860 237 SFPKWARQDFSKVVPPLDEDGRDLLSQMLHYDPNKRISAKAALAHPF 283
STKc_MOK cd07831
Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs ...
25-312 8.00e-66

Catalytic domain of the Serine/Threonine Kinase, MAPK/MAK/MRK Overlapping Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MOK, also called Renal tumor antigen 1 (RAGE-1), is widely expressed and is enriched in testis, kidney, lung, and brain. It is expressed in approximately 50% of renal cell carcinomas (RCC) and is a potential target for immunotherapy. MOK is stabilized by its association with the HSP90 molecular chaperone. It is induced by the transcription factor Cdx2 and may be involved in regulating intestinal epithelial development and differentiation. The MOK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270825 [Multi-domain]  Cd Length: 282  Bit Score: 209.82  E-value: 8.00e-66
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFR-HENIIGINDIIRAPTieqMKDVYI 103
Cdd:cd07831   1 YKILGKIGEGTFSEVLKAQSRKTGKYYAIKCMKKHFKSLEQVNNLREIQALRRLSpHPNILRLIEVLFDRK---TGRLAL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLK--TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCdLKICDFGLARVADPDHDHT 181
Cdd:cd07831  78 VFELMDMNLYELIKgrKRPLPEKRVKNYMYQLLKSLDHMHRNGIFHRDIKPENILIKDDI-LKLADFGSCRGIYSKPPYT 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 gfltEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINLKAR 261
Cdd:cd07831 157 ----EYISTRWYRAPECLLTDGYYGPKMDIWAVGCVFFEILSLFPLFPGTNELDQIAKIHDVLGTPDAEVLKKFRKSRHM 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 262 NYllSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07831 233 NY--NFPSKKGTGLRKLLPNASAEGLDLLKKLLAYDPDERITAKQALRHPY 281
PLN00009 PLN00009
cyclin-dependent kinase A; Provisional
24-314 1.00e-64

cyclin-dependent kinase A; Provisional


Pssm-ID: 177649 [Multi-domain]  Cd Length: 294  Bit Score: 207.36  E-value: 1.00e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPtieqmKDVY 102
Cdd:PLN00009   3 QYEKVEKIGEGTYGVVYKARDRVTNETIALKKIRlEQEDEGVPSTAIREISLLKEMQHGNIVRLQDVVHSE-----KRLY 77
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  103 IVQDLMETDLYKLL-KTQHLSNDH--ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARV-ADPd 177
Cdd:PLN00009  78 LVFEYLDLDLKKHMdSSPDFAKNPrlIKTYLYQILRGIAYCHSHRVLHRDLKPQNLLIDrRTNALKLADFGLARAfGIP- 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  178 hdhTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN 257
Cdd:PLN00009 157 ---VRTFTHEVVTLWYRAPEILLGSRHYSTPVDIWSVGCIFAEMVNQKPLFPGDSEIDELFKIFRILGTPNEETWPGVTS 233
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916  258 LKarNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:PLN00009 234 LP--DYKSAFPKWPPKDLATVVPTLEPAGVDLLSKMLRLDPSKRITARAALEHEYFK 288
STKc_CDK5 cd07839
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs ...
24-312 2.14e-63

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK5 is unusual in that it is regulated by non-cyclin proteins, p35 and p39. It is highly expressed in the nervous system and is critical in normal neural development and function. It plays a role in neuronal migration and differentiation, and is also important in synaptic plasticity and learning. CDK5 also participates in protecting against cell death and promoting angiogenesis. Impaired CDK5 activity is implicated in Alzheimer's disease, amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease and acute neuronal injury. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143344 [Multi-domain]  Cd Length: 284  Bit Score: 203.43  E-value: 2.14e-63
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPtieqmKDVY 102
Cdd:cd07839   1 KYEKLEKIGEGTYGTVFKAKNRETHEIVALKRVRlDDDDEGVPSSALREICLLKELKHKNIVRLYDVLHSD-----KKLT 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLLKTQHLSNDH--ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-----VAD 175
Cdd:cd07839  76 LVFEYCDQDLKKYFDSCNGDIDPeiVKSFMFQLLKGLAFCHSHNVLHRDLKPQNLLINKNGELKLADFGLARafgipVRC 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 PDHDhtgflteyVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMlSN--RPIFPGKHYLDQLNHILGILGSPSQEDLN 253
Cdd:cd07839 156 YSAE--------VVTLWYRPPDVLFGAKLYSTSIDMWSAGCIFAEL-ANagRPLFPGNDVDDQLKRIFRLLGTPTEESWP 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 254 CIINLKarNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07839 227 GVSKLP--DYKPYPMYPATTSLVNVVPKLNSTGRDLLQNLLVCNPVQRISAEEALQHPY 283
STKc_CDK1_euk cd07861
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher ...
25-313 7.58e-62

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 1 from higher eukaryotes; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK1 is also called Cell division control protein 2 (Cdc2) or p34 protein kinase, and is regulated by cyclins A, B, and E. The CDK1/cyclin A complex controls G2 phase entry and progression. CDK1/cyclin A2 has also been implicated as an important regulator of S phase events. The CDK1/cyclin B complex is critical for G2 to M phase transition. It induces mitosis by activating nuclear enzymes that regulate chromatin condensation, nuclear membrane degradation, mitosis-specific microtubule and cytoskeletal reorganization. CDK1 also associates with cyclin E and plays a role in the entry into S phase. CDK1 transcription is stable throughout the cell cycle but is modulated in some pathological conditions. It may play a role in regulating apoptosis under these conditions. In breast cancer cells, HER2 can mediate apoptosis by inactivating CDK1. Activation of CDK1 may contribute to HIV-1 induced apoptosis as well as neuronal apoptosis in neurodegenerative diseases. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270845 [Multi-domain]  Cd Length: 285  Bit Score: 199.57  E-value: 7.58e-62
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVcsaYDNVNKVR---VAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRaptieQMKD 100
Cdd:cd07861   2 YTKIEKIGEGTYGVV---YKGRNKKTgqiVAMKKIRlESEEEGVPSTAIREISLLKELQHPNIVCLEDVLM-----QENR 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLMETDLYKLLKT----QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VAD 175
Cdd:cd07861  74 LYLVFEFLSMDLKKYLDSlpkgKYMDAELVKSYLYQILQGILFCHSRRVLHRDLKPQNLLIDNKGVIKLADFGLARaFGI 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 PdhdhTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255
Cdd:cd07861 154 P----VRVYTHEVVTLWYRAPEVLLGSPRYSTPVDIWSIGTIFAEMATKKPLFHGDSEIDQLFRIFRILGTPTEDIWPGV 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 256 INLKarNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07861 230 TSLP--DYKNTFPKWKKGSLRTAVKNLDEDGLDLLEKMLIYDPAKRISAKKALVHPYF 285
STKc_PFTAIRE2 cd07870
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer ...
25-313 1.60e-61

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-2 is also referred to as ALS2CR7 (amyotrophic lateral sclerosis 2 (juvenile) chromosome region candidate 7). It may be associated with amyotrophic lateral sclerosis 2 (ALS2), an autosomal recessive form of juvenile ALS. The function of PFTAIRE-2 is not yet known. It shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270852 [Multi-domain]  Cd Length: 286  Bit Score: 198.65  E-value: 1.60e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRapTIEQMKDVYiv 104
Cdd:cd07870   2 YLNLEKLGEGSYATVYKGISRINGQLVALKVISMKTEEGVPFTAIREASLLKGLKHANIVLLHDIIH--TKETLTFVF-- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 qDLMETDLYKLLkTQHLSNDHIC---YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD-PDHDH 180
Cdd:cd07870  78 -EYMHTDLAQYM-IQHPGGLHPYnvrLFMFQLLRGLAYIHGQHILHRDLKPQNLLISYLGELKLADFGLARAKSiPSQTY 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 TGflteYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG-KHYLDQLNHILGILGSPSQE---DLNCII 256
Cdd:cd07870 156 SS----EVVTLWYRPPDVLLGATDYSSALDIWGAGCIFIEMLQGQPAFPGvSDVFEQLEKIWTVLGVPTEDtwpGVSKLP 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 257 NLKARNYLLSLPHKNKVPWNRLfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07870 232 NYKPEWFLPCKPQQLRVVWKRL--SRPPKAEDLASQMLMMFPKDRISAQDALLHPYF 286
STKc_CDKL2_3 cd07846
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; ...
24-312 1.67e-61

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 2 and 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL2, also called p56 KKIAMRE, is expressed in testis, kidney, lung, and brain. It functions mainly in mature neurons and plays an important role in learning and memory. Inactivation of CDKL3, also called NKIAMRE (NKIATRE in rat), by translocation is associated with mild mental retardation. It has been reported that CDKL3 is lost in leukemic cells having a chromosome arm 5q deletion, and may contribute to the transformed phenotype. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270836 [Multi-domain]  Cd Length: 286  Bit Score: 198.80  E-value: 1.67e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQR-TLREIKILLRFRHENIIGINDIIRaptieQMKDVY 102
Cdd:cd07846   2 KYENLGLVGEGSYGMVMKCRHKETGQIVAIKKFLESEDDKMVKKiAMREIKMLKQLRHENLVNLIEVFR-----RKKRWY 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLME-TDLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHD 179
Cdd:cd07846  77 LVFEFVDhTVLDDLEKYPNgLDESRVRKYLFQILRGIDFCHSHNIIHRDIKPENILVSQSGVVKLCDFGFARtLAAPGEV 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 HTgfltEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILG--SPSQEDLNCiin 257
Cdd:cd07846 157 YT----DYVATRWYRAPELLVGDTKYGKAVDVWAVGCLVTEMLTGEPLFPGDSDIDQLYHIIKCLGnlIPRHQELFQ--- 229
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 258 lkaRNYL---LSLPH-KNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07846 230 ---KNPLfagVRLPEvKEVEPLERRYPKLSGVVIDLAKKCLHIDPDKRPSCSELLHHEF 285
STKc_CDK4 cd07863
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs ...
24-313 4.33e-61

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK4 partners with all three D-type cyclins (D1, D2, and D3) and is also regulated by INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein and plays a role in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the nucleus. CDK4 also shows kinase activity towards Smad3, a signal transducer of TGF-beta signaling which modulates transcription and plays a role in cell proliferation and apoptosis. CDK4 is inhibited by the p21 inhibitor and is specifically mutated in human melanoma. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143368 [Multi-domain]  Cd Length: 288  Bit Score: 197.88  E-value: 4.33e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLR---FRHENIIGINDIIRAPTIEQMK 99
Cdd:cd07863   1 QYEPVAEIGVGAYGTVYKARDPHSGHFVALKSVRvQTNEDGLPLSTVREVALLKRleaFDHPNIVRLMDVCATSRTDRET 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 DVYIVQDLMETDLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVadp 176
Cdd:cd07863  81 KVTLVFEHVDQDLRTYLDKvppPGLPAETIKDLMRQFLRGLDFLHANCIVHRDLKPENILVTSGGQVKLADFGLARI--- 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 dHDHTGFLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
Cdd:cd07863 158 -YSCQMALTPVVVTLWYRAPEVLLQST-YATPVDMWSVGCIFAEMFRRKPLFCGNSEADQLGKIFDLIGLPPEDDWPRDV 235
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 257 NLKARNYllslPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07863 236 TLPRGAF----SPRGPRPVQSVVPEIEESGAQLLLEMLTFNPHKRISAFRALQHPFF 288
STKc_PCTAIRE1 cd07873
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer ...
25-314 1.58e-60

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-1 is expressed ubiquitously and is localized in the cytoplasm. Its kinase activity is cell cycle dependent and peaks at the S and G2 phases. PCTAIRE-1 is highly expressed in the brain and may play a role in regulating neurite outgrowth. It can also associate with Trap (Tudor repeat associator with PCTAIRE-2), a physiological partner of PCTAIRE-2; with p11, a small dimeric protein with similarity to S100; and with 14-3-3 proteins, mediators of phosphorylation-dependent interactions in many different proteins. PCTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270854 [Multi-domain]  Cd Length: 297  Bit Score: 196.76  E-value: 1.58e-60
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYCQRT-LREIKILLRFRHENIIGINDIIRAPtieqmKDVYI 103
Cdd:cd07873   4 YIKLDKLGEGTYATVYKGRSKLTDNLVALKEIR-LEHEEGAPCTaIREVSLLKDLKHANIVTLHDIIHTE-----KSLTL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLK-TQHLSNDH-ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD-Pdhdh 180
Cdd:cd07873  78 VFEYLDKDLKQYLDdCGNSINMHnVKLFLFQLLRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSiP---- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIIN--- 257
Cdd:cd07873 154 TKTYSNEVVTLWYRPPDILLGSTDYSTQIDMWGVGCIFYEMSTGRPLFPGSTVEEQLHFIFRILGTPTEETWPGILSnee 233
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 258 LKARNYllslPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd07873 234 FKSYNY----PKYRADALHNHAPRLDSDGADLLSKLLQFEGRKRISAEEAMKHPYFH 286
STKc_CDK9 cd07865
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs ...
24-312 1.52e-59

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK9, together with a cyclin partner (cyclin T1, T2a, T2b, or K), is the main component of distinct positive transcription elongation factors (P-TEFb), which function as Ser2 C-terminal domain kinases of RNA polymerase II. P-TEFb participates in multiple steps of gene expression including transcription elongation, mRNA synthesis, processing, export, and translation. It also plays a role in mediating cytokine induced transcription networks such as IL6-induced STAT3 signaling. In addition, the CDK9/cyclin T2a complex promotes muscle differentiation and enhances the function of some myogenic regulatory factors. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK9 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270848 [Multi-domain]  Cd Length: 310  Bit Score: 194.51  E-value: 1.52e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMK--- 99
Cdd:cd07865  13 KYEKLAKIGQGTFGEVFKARHRKTGQIVALKKVlMENEKEGFPITALREIKILQLLKHENVVNLIEICRTKATPYNRykg 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 DVYIVQDLMETDLYKLLKTQHL--SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV-ADP 176
Cdd:cd07865  93 SIYLVFEFCEHDLAGLLSNKNVkfTLSEIKKVMKMLLNGLYYIHRNKILHRDMKAANILITKDGVLKLADFGLARAfSLA 172
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 DHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII 256
Cdd:cd07865 173 KNSQPNRYTNRVVTLWYRPPELLLGERDYGPPIDMWGAGCIMAEMWTRSPIMQGNTEQHQLTLISQLCGSITPEVWPGVD 252
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 257 NLKA-RNYLLSLPHKNKVPwNRLFP-NADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07865 253 KLELfKKMELPQGQKRKVK-ERLKPyVKDPYALDLIDKLLVLDPAKRIDADTALNHDF 309
STKc_PCTAIRE3 cd07871
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer ...
25-313 1.98e-59

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-3 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-3 shows a restricted pattern of expression and is present in brain, kidney, and intestine. It is elevated in Alzheimer's disease (AD) and has been shown to associate with paired helical filaments (PHFs) and stimulate Tau phosphorylation. As AD progresses, phosphorylated Tau aggregates and forms PHFs, which leads to the formation of neurofibrillary tangles. In human glioma cells, PCTAIRE-3 induces cell cycle arrest and cell death. PCTAIRE-3 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270853 [Multi-domain]  Cd Length: 288  Bit Score: 193.69  E-value: 1.98e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYCQRT-LREIKILLRFRHENIIGINDIIRAPtieqmKDVYI 103
Cdd:cd07871   7 YVKLDKLGEGTYATVFKGRSKLTENLVALKEIR-LEHEEGAPCTaIREVSLLKNLKHANIVTLHDIIHTE-----RCLTL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLKT--QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD-Pdhdh 180
Cdd:cd07871  81 VFEYLDSDLKQYLDNcgNLMSMHNVKIFMFQLLRGLSYCHKRKILHRDLKPQNLLINEKGELKLADFGLARAKSvP---- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCII-NLK 259
Cdd:cd07871 157 TKTYSNEVVTLWYRPPDVLLGSTEYSTPIDMWGVGCILYEMATGRPMFPGSTVKEELHLIFRLLGTPTEETWPGVTsNEE 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 260 ARNYllSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07871 237 FRSY--LFPQYRAQPLINHAPRLDTDGIDLLSSLLLYETKSRISAEAALRHSYF 288
STKc_CDKL1_4 cd07847
Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; ...
24-312 2.27e-59

Catalytic domain of the Serine/Threonine Kinases, Cyclin-Dependent protein Kinase Like 1 and 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDKL1, also called p42 KKIALRE, is a glial protein that is upregulated in gliosis. It is present in neuroblastoma and A431 human carcinoma cells, and may be implicated in neoplastic transformation. The function of CDKL4 is unknown. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL1/4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270837 [Multi-domain]  Cd Length: 286  Bit Score: 193.36  E-value: 2.27e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQR-TLREIKILLRFRHENIIGINDIIRaptieQMKDVY 102
Cdd:cd07847   2 KYEKLSKIGEGSYGVVFKCRNRETGQIVAIKKFVESEDDPVIKKiALREIRMLKQLKHPNLVNLIEVFR-----RKRKLH 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLME-TDLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
Cdd:cd07847  77 LVFEYCDhTVLNELEKNPRgVPEHLIKKIIWQTLQAVNFCHKHNCIHRDVKPENILITKQGQIKLCDFGFARILTGPGDD 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 tgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS--PSQEDLnciinL 258
Cdd:cd07847 157 ---YTDYVATRWYRAPELLVGDTQYGPPVDVWAIGCVFAELLTGQPLWPGKSDVDQLYLIRKTLGDliPRHQQI-----F 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 259 KARNYL--LSLPH-KNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07847 229 STNQFFkgLSIPEpETREPLESKFPNISSPALSFLKGCLQMDPTERLSCEELLEHPY 285
STKc_CdkB_plant cd07837
Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; ...
25-314 6.84e-57

Catalytic domain of the Serine/Threonine Kinase, Plant B-type Cyclin-Dependent protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The plant-specific B-type CDKs are expressed from the late S to the M phase of the cell cycle. They are characterized by the cyclin binding motif PPT[A/T]LRE. They play a role in controlling mitosis and integrating developmental pathways, such as stomata and leaf development. CdkB has been shown to associate with both cyclin B, which controls G2/M transition, and cyclin D, which acts as a mediator in linking extracellular signals to the cell cycle. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CdkB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270830 [Multi-domain]  Cd Length: 294  Bit Score: 186.96  E-value: 6.84e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIgindiIRAPTIEQMKD--- 100
Cdd:cd07837   3 YEKLEKIGEGTYGKVYKARDKNTGKLVALKKTRlEMEEEGVPSTALREVSLLQMLSQSIYI-----VRLLDVEHVEEngk 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 --VYIVQDLMETDLYKLLKTQHLSNDH------ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD-LKICDFGLA 171
Cdd:cd07837  78 plLYLVFEYLDTDLKKFIDSYGRGPHNplpaktIQSFMYQLCKGVAHCHSHGVMHRDLKPQNLLVDKQKGlLKIADLGLG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 172 RV-ADPDHDHTgfltEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQE 250
Cdd:cd07837 158 RAfTIPIKSYT----HEIVTLWYRAPEVLLGSTHYSTPVDMWSVGCIFAEMSRKQPLFPGDSELQQLLHIFRLLGTPNEE 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916 251 DLNCIINLKARNyllSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd07837 234 VWPGVSKLRDWH---EYPQWKPQDLSRAVPDLEPEGVDLLTKMLAYDPAKRISAKAALQHPYFD 294
STKc_CK2_alpha cd14132
Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; STKs catalyze the ...
24-312 2.09e-56

Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK2 is a tetrameric protein with two catalytic (alpha) and two regulatory (beta) subunits. It is constitutively active and ubiquitously expressed, and is found in the cytoplasm, nucleus, as well as in the plasma membrane. It phosphorylates a wide variety of substrates including gylcogen synthase, cell cycle proteins, nuclear proteins (e.g. DNA topoisomerase II), and ion channels (e.g. ENaC), among others. It may be considered a master kinase controlling the activity or lifespan of many other kinases and exerting its effect over cell fate, gene expression, protein synthesis and degradation, and viral infection. CK2 is implicated in every stage of the cell cycle and is required for cell cycle progression. It plays crucial roles in cell differentiation, proliferation, and survival, and is thus implicated in cancer. CK2 is not an oncogene by itself but elevated CK2 levels create an environment that enhances the survival of tumor cells. The CK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271034 [Multi-domain]  Cd Length: 306  Bit Score: 186.21  E-value: 2.09e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCqrtlREIKILLRFR-HENIIGINDIIRAPtieQMKDVY 102
Cdd:cd14132  19 DYEIIRKIGRGKYSEVFEGINIGNNEKVVIKVLKPVKKKKIK----REIKILQNLRgGPNIVKLLDVVKDP---QSKTPS 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLME-TDLYKLLKTqhLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD-LKICDFGLArvadpDHDH 180
Cdd:cd14132  92 LIFEYVNnTDFKTLYPT--LTDYDIRYYMYELLKALDYCHSKGIMHRDVKPHNIMIDHEKRkLRLIDWGLA-----EFYH 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 TGflTEY---VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML-SNRPIFPGKHYLDQLNHILGILGSpsqEDLNCII 256
Cdd:cd14132 165 PG--QEYnvrVASRYYKGPELLVDYQYYDYSLDMWSLGCMLASMIfRKEPFFHGHDNYDQLVKIAKVLGT---DDLYAYL 239
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 257 NlkarNYLLSLPH--------KNKVPWNRLFPN-----ADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14132 240 D----KYGIELPPrlndilgrHSKKPWERFVNSenqhlVTPEALDLLDKLLRYDHQERITAKEAMQHPY 304
STKc_CAMK cd05117
The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of ...
24-311 9.57e-56

The catalytic domain of CAMK family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. CAMKIV is implicated in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors, as well as in T-cell development and signaling. The CAMK family also consists of other related kinases including the Phosphorylase kinase Gamma subunit (PhKG), the C-terminal kinase domains of Ribosomal S6 kinase (RSK) and Mitogen and stress-activated kinase (MSK), Doublecortin-like kinase (DCKL), and the MAPK-activated protein kinases MK2, MK3, and MK5, among others. The CAMK family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270687 [Multi-domain]  Cd Length: 258  Bit Score: 183.06  E-value: 9.57e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVY 102
Cdd:cd05117   1 KYELGKVLGRGSFGVVRLAVHKKTGEEYAVKIIDkKKLKSEDEEMLRREIEILKRLDHPNIVKLYEVF-----EDDKNLY 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLME-TDLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT---CDLKICDFGLARVADPD 177
Cdd:cd05117  76 LVMELCTgGELFdRIVKKGSFSEREAAKIMKQILSAVAYLHSQGIVHRDLKPENILLASKdpdSPIKIIDFGLAKIFEEG 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 hdhtGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhyldqlnhilgilgspSQEDLncIIN 257
Cdd:cd05117 156 ----EKLKTVCGTPYYVAPEV-LKGKGYGKKCDIWSLGVILYILLCGYPPFYGE----------------TEQEL--FEK 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 258 LKARNYLLSLPHKNKVpwnrlfpnaDSKALDLLDKMLTFNPHKRIEVEQALAHP 311
Cdd:cd05117 213 ILKGKYSFDSPEWKNV---------SEEAKDLIKRLLVVDPKKRLTAAEALNHP 257
STKc_CDK6 cd07862
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs ...
24-312 2.35e-55

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK6 is regulated by D-type cyclins and INK4 inhibitors. It is active towards the retinoblastoma (pRb) protein, implicating it to function in regulating the early G1 phase of the cell cycle. It is expressed ubiquitously and is localized in the cytoplasm. It is also present in the ruffling edge of spreading fibroblasts and may play a role in cell spreading. It binds to the p21 inhibitor without any effect on its own activity and it is overexpressed in squamous cell carcinomas and neuroblastomas. CDK6 has also been shown to inhibit cell differentiation in many cell types. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270846 [Multi-domain]  Cd Length: 290  Bit Score: 182.93  E-value: 2.35e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVR-VAIKKIS-PFEHQTYCQRTLREIKILLR---FRHENIIGINDIIRAPTIEQM 98
Cdd:cd07862   2 QYECVAEIGEGAYGKVFKARDLKNGGRfVALKRVRvQTGEEGMPLSTIREVAVLRHletFEHPNVVRLFDVCTVSRTDRE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLMETDLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVad 175
Cdd:cd07862  82 TKLTLVFEHVDQDLTTYLDKvpePGVPTETIKDMMFQLLRGLDFLHSHRVVHRDLKPQNILVTSSGQIKLADFGLARI-- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 pdHDHTGFLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI 255
Cdd:cd07862 160 --YSFQMALTSVVVTLWYRAPEVLLQSS-YATPVDLWSVGCIFAEMFRRKPLFRGSSDVDQLGKILDVIGLPGEEDWPRD 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 256 INLkARNYLLSLPHKnkvPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd07862 237 VAL-PRQAFHSKSAQ---PIEKFVTDIDELGKDLLLKCLTFNPAKRISAYSALSHPY 289
STKc_PCTAIRE2 cd07872
Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer ...
25-314 3.21e-55

Catalytic domain of the Serine/Threonine Kinase, PCTAIRE-2 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PCTAIRE-2 is specifically expressed in neurons in the central nervous system, mainly in terminally differentiated neurons. It associates with Trap (Tudor repeat associator with PCTAIRE-2) and could play a role in regulating mitochondrial function in neurons. PCTAIRE-2 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PCTAIRE-2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143377 [Multi-domain]  Cd Length: 309  Bit Score: 183.27  E-value: 3.21e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYCQRT-LREIKILLRFRHENIIGINDIIRAPtieqmKDVYI 103
Cdd:cd07872   8 YIKLEKLGEGTYATVFKGRSKLTENLVALKEIR-LEHEEGAPCTaIREVSLLKDLKHANIVTLHDIVHTD-----KSLTL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLKT--QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDhdhT 181
Cdd:cd07872  82 VFEYLDKDLKQYMDDcgNIMSMHNVKIFLYQILRGLAYCHRRKVLHRDLKPQNLLINERGELKLADFGLARAKSVP---T 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCI-INLKA 260
Cdd:cd07872 159 KTYSNEVVTLWYRPPDVLLGSSEYSTQIDMWGVGCIFFEMASGRPLFPGSTVEDELHLIFRLLGTPTEETWPGIsSNDEF 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 261 RNYllSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd07872 239 KNY--NFPKYKPQPLINHAPRLDTEGIELLTKFLQYESKKRISAEEAMKHAYFR 290
PKc cd00180
Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group ...
31-221 5.12e-55

Catalytic domain of Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. PKs make up a large family of serine/threonine kinases (STKs), protein tyrosine kinases (PTKs), and dual-specificity PKs that phosphorylate both serine/threonine and tyrosine residues of target proteins. Majority of protein phosphorylation occurs on serine residues while only 1% occurs on tyrosine residues. Protein phosphorylation is a mechanism by which a wide variety of cellular proteins, such as enzymes and membrane channels, are reversibly regulated in response to certain stimuli. PKs often function as components of signal transduction pathways in which one kinase activates a second kinase, which in turn, may act on other kinases; this sequential action transmits a signal from the cell surface to target proteins, which results in cellular responses. The PK family is one of the largest known protein families with more than 100 homologous yeast enzymes and more than 500 human proteins. A fraction of PK family members are pseudokinases that lack crucial residues for catalytic activity. The mutiplicity of kinases allows for specific regulation according to substrate, tissue distribution, and cellular localization. PKs regulate many cellular processes including proliferation, division, differentiation, motility, survival, metabolism, cell-cycle progression, cytoskeletal rearrangement, immunity, and neuronal functions. Many kinases are implicated in the development of various human diseases including different types of cancer. The PK family is part of a larger superfamily that includes the catalytic domains of RIO kinases, aminoglycoside phosphotransferase, choline kinase, phosphoinositide 3-kinase (PI3K), and actin-fragmin kinase.


Pssm-ID: 270622 [Multi-domain]  Cd Length: 215  Bit Score: 179.77  E-value: 5.12e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLMET 110
Cdd:cd00180   1 LGKGSFGKVYKARDKETGKKVAVKVIPKEKLKKLLEELLREIEILKKLNHPNIVKLYDVF-----ETENFLYLVMEYCEG 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 -DLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEY 187
Cdd:cd00180  76 gSLKDLLKENkgPLSEEEALSILRQLLSALEYLHSNGIIHRDLKPENILLDSDGTVKLADFGLAKDLDSDDSLLKTTGGT 155
                       170       180       190
                ....*....|....*....|....*....|....
gi 66932916 188 vaTRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM 221
Cdd:cd00180 156 --TPPYYAPPELLGGRYYGPKVDIWSLGVILYEL 187
PKc_DYRK cd14210
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
24-313 1.12e-54

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase; Protein Kinases (PKs), Dual-specificity tYrosine-phosphorylated and -Regulated Kinase (DYRK) subfamily, catalytic (c) domain. Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. The DYRK subfamily is part of a larger superfamily that includes the catalytic domains of other protein S/T PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K). DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. Vertebrates contain multiple DYRKs (DYRK1-4) and mammals contain two types of DYRK1 proteins, DYRK1A and DYRK1B. DYRK1A is involved in neuronal differentiation and is implicated in the pathogenesis of DS (Down syndrome). DYRK1B plays a critical role in muscle differentiation by regulating transcription, cell motility, survival, and cell cycle progression. It is overexpressed in many solid tumors where it acts as a tumor survival factor. DYRK2 promotes apoptosis in response to DNA damage by phosphorylating the tumor suppressor p53, while DYRK3 promotes cell survival by phosphorylating SIRT1 and promoting p53 deacetylation. DYRK4 is a testis-specific kinase that may function during spermiogenesis.


Pssm-ID: 271112 [Multi-domain]  Cd Length: 311  Bit Score: 181.97  E-value: 1.12e-54
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINDIIRaptieqMKDVY- 102
Cdd:cd14210  14 RYEVLSVLGKGSFGQVVKCLDHKTGQLVAIKIIR--NKKRFHQQALVEVKILKHLNDNDPDDKHNIVR------YKDSFi 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 ------IVQDLMETDLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL--NTTCDLKICDFGLA 171
Cdd:cd14210  86 frghlcIVFELLSINLYELLKSNNfqgLSLSLIRKFAKQILQALQFLHKLNIIHCDLKPENILLkqPSKSSIKVIDFGSS 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 172 RVadpdHDHTGFltEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQED 251
Cdd:cd14210 166 CF----EGEKVY--TYIQSRFYRAPEVILGLP-YDTAIDMWSLGCILAELYTGYPLFPGENEEEQLACIMEVLGVPPKSL 238
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 252 LNciiNLKARNYLLSL---PHKNKVPWNRLFP-----------NADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14210 239 ID---KASRRKKFFDSngkPRPTTNSKGKKRRpgskslaqvlkCDDPSFLDFLKKCLRWDPSERMTPEEALQHPWI 311
PKc_DYRK_like cd14133
Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like ...
25-313 1.45e-52

Catalytic domain of Dual-specificity tYrosine-phosphorylated and -Regulated Kinase-like protein kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity DYRKs and YAK1, as well as the S/T kinases (STKs), HIPKs. DYRKs and YAK1 autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. Proteins in this subfamily play important roles in cell proliferation, differentiation, survival, growth, and development. The DYRK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271035 [Multi-domain]  Cd Length: 262  Bit Score: 174.76  E-value: 1.45e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINDIIRaptieqMKDVY-- 102
Cdd:cd14133   1 YEVLEVLGKGTFGQVVKCYDLLTGEEVALKIIK--NNKDYLDQSLDEIRLLELLNKKDKADKYHIVR------LKDVFyf 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 -----IVQDLMETDLYKLLK---TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL--NTTCDLKICDFGLAr 172
Cdd:cd14133  73 knhlcIVFELLSQNLYEFLKqnkFQYLSLPRIRKIAQQILEALVFLHSLGLIHCDLKPENILLasYSRCQIKIIDFGSS- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 VADPDHDHTgflteYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 252
Cdd:cd14133 152 CFLTQRLYS-----YIQSRYYRAPEVILGLP-YDEKIDMWSLGCILAELYTGEPLFPGASEVDQLARIIGTIGIPPAHML 225
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 253 nciinlkarnyllslphknkvpWNRlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14133 226 ----------------------DQG--KADDELFVDFLKKLLEIDPKERPTASQALSHPWL 262
PTZ00036 PTZ00036
glycogen synthase kinase; Provisional
24-346 4.35e-52

glycogen synthase kinase; Provisional


Pssm-ID: 173333 [Multi-domain]  Cd Length: 440  Bit Score: 178.69  E-value: 4.35e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   24 RYTNLSY-----IGEGAYGMVCSAYDNVNKVRVAIKKI--SPfehqtycQRTLREIKILLRFRHENIIGINDIIRAPTIE 96
Cdd:PTZ00036  62 RSPNKSYklgniIGNGSFGVVYEAICIDTSEKVAIKKVlqDP-------QYKNRELLIMKNLNHINIIFLKDYYYTECFK 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   97 Q-MKDVY--IVQDLMETDLYKLLKTQHLSNDHICYFL-----YQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICD 167
Cdd:PTZ00036 135 KnEKNIFlnVVMEFIPQTVHKYMKHYARNNHALPLFLvklysYQLCRALAYIHSKFICHRDLKPQNLLIDpNTHTLKLCD 214
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  168 FGLARVADPDHDHTgfltEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSP 247
Cdd:PTZ00036 215 FGSAKNLLAGQRSV----SYICSRFYRAPELMLGATNYTTHIDLWSLGCIIAEMILGYPIFSGQSSVDQLVRIIQVLGTP 290
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  248 SQEDLNcIINlkaRNYL-LSLPHKNKVPWNRLFPNAD-SKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSdepia 325
Cdd:PTZ00036 291 TEDQLK-EMN---PNYAdIKFPDVKPKDLKKVFPKGTpDDAINFISQFLKYEPLKRLNPIEALADPFFDDLRDPC----- 361
                        330       340
                 ....*....|....*....|....*..
gi 66932916  326 eapFKFDMELDDLP------KEKLKEL 346
Cdd:PTZ00036 362 ---IKLPKYIDKLPdlfnfcDAEIKEM 385
STKc_CDKL5 cd07848
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs ...
24-311 6.50e-52

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase Like 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mutations in the gene encoding CDKL5, previously called STK9, are associated with early onset epilepsy and severe mental retardation [X-linked infantile spasm syndrome (ISSX) or West syndrome]. In addition, CDKL5 mutations also sometimes cause a phenotype similar to Rett syndrome (RTT), a progressive neurodevelopmental disorder. These pathogenic mutations are located in the N-terminal portion of the protein within the kinase domain. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDKL5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270838 [Multi-domain]  Cd Length: 287  Bit Score: 174.03  E-value: 6.50e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE-HQTYCQRTLREIKILLRFRHENIIGINDIIRaptieQMKDVY 102
Cdd:cd07848   2 KFEVLGVVGEGAYGVVLKCRHKETKEIVAIKKFKDSEeNEEVKETTLRELKMLRTLKQENIVELKEAFR-----RRGKLY 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLLktQHLSN----DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDH 178
Cdd:cd07848  77 LVFEYVEKNMLELL--EEMPNgvppEKVRSYIYQLIKAIHWCHKNDIVHRDIKPENLLISHNDVLKLCDFGFARNLSEGS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 DHTgfLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINl 258
Cdd:cd07848 155 NAN--YTEYVATRWYRSPELLLGAP-YGKAVDMWSVGCILGELSDGQPLFPGESEIDQLFTIQKVLGPLPAEQMKLFYS- 230
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 259 KARNYLLSLPHKN--KVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHP 311
Cdd:cd07848 231 NPRFHGLRFPAVNhpQSLERRYLGILSGVLLDLMKNLLKLNPTDRYLTEQCLNHP 285
STKc_PknB_like cd14014
Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs ...
24-310 5.78e-51

Catalytic domain of bacterial Serine/Threonine kinases, PknB and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes many bacterial eukaryotic-type STKs including Staphylococcus aureus PknB (also called PrkC or Stk1), Bacillus subtilis PrkC, and Mycobacterium tuberculosis Pkn proteins (PknB, PknD, PknE, PknF, PknL, and PknH), among others. S. aureus PknB is the only eukaryotic-type STK present in this species, although many microorganisms encode for several such proteins. It is important for the survival and pathogenesis of S. aureus as it is involved in the regulation of purine and pyrimidine biosynthesis, cell wall metabolism, autolysis, virulence, and antibiotic resistance. M. tuberculosis PknB is essential for growth and it acts on diverse substrates including proteins involved in peptidoglycan synthesis, cell division, transcription, stress responses, and metabolic regulation. B. subtilis PrkC is located at the inner membrane of endospores and functions to trigger spore germination. Bacterial STKs in this subfamily show varied domain architectures. The well-characterized members such as S. aureus and M. tuberculosis PknB, and B. subtilis PrkC, contain an N-terminal cytosolic kinase domain, a transmembrane (TM) segment, and mutliple C-terminal extracellular PASTA domains. The PknB subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270916 [Multi-domain]  Cd Length: 260  Bit Score: 170.46  E-value: 5.78e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISP--FEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIeqmkdV 101
Cdd:cd14014   1 RYRLVRLLGRGGMGEVYRARDTLLGRPVAIKVLRPelAEDEEFRERFLREARALARLSHPNIVRVYDVGEDDGR-----P 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLME-TDLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpDHD 179
Cdd:cd14014  76 YIVMEYVEgGSLADLLRERGpLPPREALRILAQIADALAAAHRAGIVHRDIKPANILLTEDGRVKLTDFGIARALG-DSG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 HTGFlTEYVATRWYRAPEIMLNsKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsqedlnciinlk 259
Cdd:cd14014 155 LTQT-GSVLGTPAYMAPEQARG-GPVDPRSDIYSLGVVLYELLTGRPPFDGDSPAAVLAKHL------------------ 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 260 arnyllslpHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKR----IEVEQALAH 310
Cdd:cd14014 215 ---------QEAPPPPSPLNPDVPPALDAIILRALAKDPEERpqsaAELLAALRA 260
STKc_PFTAIRE1 cd07869
Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer ...
19-313 3.91e-50

Catalytic domain of the Serine/Threonine Kinase, PFTAIRE-1 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PFTAIRE-1 is widely expressed except in the spleen and thymus. It is highly expressed in the brain, heart, pancreas, testis, and ovary, and is localized in the cytoplasm. It is regulated by cyclin D3 and is inhibited by the p21 cell cycle inhibitor. It has also been shown to interact with the membrane-associated cyclin Y, which recruits the protein to the plasma membrane. PFTAIRE-1 shares sequence similarity with Cyclin-Dependent Kinases (CDKs), which belong to a large family of STKs that are regulated by their cognate cyclins. Together, CDKs and cyclins are involved in the control of cell-cycle progression, transcription, and neuronal function. The PFTAIRE-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 143374 [Multi-domain]  Cd Length: 303  Bit Score: 169.87  E-value: 3.91e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  19 FDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRapTIEQM 98
Cdd:cd07869   1 FGKADSYEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEEEGTPFTAIREASLLKGLKHANIVLLHDIIH--TKETL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYivqDLMETDLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD- 175
Cdd:cd07869  79 TLVF---EYVHTDLCQYMDKHpgGLHPENVKLFLFQLLRGLSYIHQRYILHRDLKPQNLLISDTGELKLADFGLARAKSv 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 PDHDHtgflTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG-KHYLDQLNHILGILGSPSQED--- 251
Cdd:cd07869 156 PSHTY----SNEVVTLWYRPPDVLLGSTEYSTCLDMWGVGCIFVEMIQGVAAFPGmKDIQDQLERIFLVLGTPNEDTwpg 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916 252 LNCIINLKARNYLLSLPHKNKVPWNRLfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07869 232 VHSLPHFKPERFTLYSPKNLRQAWNKL--SYVNHAEDLASKLLQCFPKNRLSAQAALSHEYF 291
Pkinase pfam00069
Protein kinase domain;
25-313 2.46e-48

Protein kinase domain;


Pssm-ID: 459660 [Multi-domain]  Cd Length: 217  Bit Score: 162.41  E-value: 2.46e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916    25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPfEHQT--YCQRTLREIKILLRFRHENIIGINDIIRAPtieqmKDVY 102
Cdd:pfam00069   1 YEVLRKLGSGSFGTVYKAKHRDTGKIVAIKKIKK-EKIKkkKDKNILREIKILKKLNHPNIVRLYDAFEDK-----DNLY 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   103 IVQDLME-TDLYKLLKTQ-HLSNDHICYFLYQILRGLKyihsanvlhrdlkpsnlllnttcdlkicdfglarvadpdhdH 180
Cdd:pfam00069  75 LVLEYVEgGSLFDLLSEKgAFSEREAKFIMKQILEGLE-----------------------------------------S 113
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   181 TGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsqedlnciinlka 260
Cdd:pfam00069 114 GSSLTTFVGTPWYMAPEV-LGGNPYGPKVDVWSLGCILYELLTGKPPFPGINGNEIYELII------------------- 173
                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 66932916   261 rnyllslphKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:pfam00069 174 ---------DQPYAFPELPSNLSEEAKDLLKKLLKKDPSKRLTATQALQHPWF 217
PKc_STE cd05122
Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the ...
25-313 1.09e-46

Catalytic domain of STE family Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. This family is composed of STKs, and some dual-specificity PKs that phosphorylate both threonine and tyrosine residues of target proteins. Most members are kinases involved in mitogen-activated protein kinase (MAPK) signaling cascades, acting as MAPK kinases (MAPKKs), MAPKK kinases (MAPKKKs), or MAPKKK kinases (MAP4Ks). The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising of the MAPK, which is phosphorylated and activated by a MAPKK, which itself is phosphorylated and activated by a MAPKKK. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAPKKK to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Other STE family members include p21-activated kinases (PAKs) and class III myosins, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain, which can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, as well as autophosphorylate the C-terminal motor domain. They play an important role in maintaining the structural integrity of photoreceptor cell microvilli. The STE family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270692 [Multi-domain]  Cd Length: 254  Bit Score: 159.29  E-value: 1.09e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIsPFEHQTYCQRTLREIKILLRFRHENIIGINDiirapTIEQMKDVYIV 104
Cdd:cd05122   2 FEILEKIGKGGFGVVYKARHKKTGQIVAIKKI-NLESKEKKESILNEIAILKKCKHPNIVKYYG-----SYLKKDELWIV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLME----TDLYKLLKtQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-RVADpdhd 179
Cdd:cd05122  76 MEFCSggslKDLLKNTN-KTLTEQQIAYVCKEVLKGLEYLHSHGIIHRDIKAANILLTSDGEVKLIDFGLSaQLSD---- 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 hTGFLTEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqedlnciinlk 259
Cdd:cd05122 151 -GKTRNTFVGTPYWMAPE-VIQGKPYGFKADIWSLGITAIEMAEGKPPYSELPPMKALFLI------------------- 209
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 260 ARNYLLSLPHKNKVpwnrlfpnadSKAL-DLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd05122 210 ATNGPPGLRNPKKW----------SKEFkDFLKKCLQKDPEKRPTAEQLLKHPFI 254
STKc_Chk2 cd14084
Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze ...
23-313 2.26e-46

Catalytic domain of the Serine/Threonine kinase, Cell cycle Checkpoint Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Checkpoint Kinase 2 (Chk2) plays an important role in cellular responses to DNA double-strand breaks and related lesions. It is phosphorylated and activated by ATM kinase, resulting in its dissociation from sites of damage to phosphorylate downstream targets such as BRCA1, p53, cell cycle transcription factor E2F1, the promyelocytic leukemia protein (PML) involved in apoptosis, and CDC25 phosphatases, among others. Mutations in Chk2 is linked to a variety of cancers including familial breast cancer, myelodysplastic syndromes, prostate cancer, lung cancer, and osteosarcomas. Chk2 contains an N-terminal SQ/TQ cluster domain (SCD), a central forkhead-associated (FHA) domain, and a C-terminal catalytic kinase domain. The Chk2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270986 [Multi-domain]  Cd Length: 275  Bit Score: 159.10  E-value: 2.26e-46
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  23 PRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPfEHQTYCQRT--------LREIKILLRFRHENIIGINDIIRAPt 94
Cdd:cd14084   6 KKYIMSRTLGSGACGEVKLAYDKSTCKKVAIKIINK-RKFTIGSRReinkprniETEIEILKKLSHPCIIKIEDFFDAE- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  95 ieqmKDVYIVQDLMET-DLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT---CDLKICDFG 169
Cdd:cd14084  84 ----DDYYIVLELMEGgELFdRVVSNKRLKEAICKLYFYQMLLAVKYLHSNGIIHRDLKPENVLLSSQeeeCLIKITDFG 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 170 LARVAdpdhDHTGFLTEYVATRWYRAPEIMLN--SKGYTKSIDIWSVGCILAEMLSNRPIFPGkHYLDqlnhilgilgsp 247
Cdd:cd14084 160 LSKIL----GETSLMKTLCGTPTYLAPEVLRSfgTEGYTRAVDCWSLGVILFICLSGYPPFSE-EYTQ------------ 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 248 sqedlnciinLKARNYLLSLPHKNKVPWNRlfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14084 223 ----------MSLKEQILSGKYTFIPKAWK---NVSEEAKDLVKKMLVVDPSRRPSIEEALEHPWL 275
SPS1 COG0515
Serine/threonine protein kinase [Signal transduction mechanisms];
21-310 4.45e-45

Serine/threonine protein kinase [Signal transduction mechanisms];


Pssm-ID: 440281 [Multi-domain]  Cd Length: 482  Bit Score: 160.95  E-value: 4.45e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  21 VGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISP--FEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIeqm 98
Cdd:COG0515   5 LLGRYRILRLLGRGGMGVVYLARDLRLGRPVALKVLRPelAADPEARERFRREARALARLNHPNIVRVYDVGEEDGR--- 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 kdVYIVQDLME-TDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD- 175
Cdd:COG0515  82 --PYLVMEYVEgESLADLLRRRgPLPPAEALRILAQLAEALAAAHAAGIVHRDIKPANILLTPDGRVKLIDFGIARALGg 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 PDHDHTGFLteyVATRWYRAPEIMLNSKGYTKSiDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsqedlnci 255
Cdd:COG0515 160 ATLTQTGTV---VGTPGYMAPEQARGEPVDPRS-DVYSLGVTLYELLTGRPPFDGDSPAELLRAHL-------------- 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 256 inlkarnyllslpHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRI----EVEQALAH 310
Cdd:COG0515 222 -------------REPPPPPSELRPDLPPALDAIVLRALAKDPEERYqsaaELAAALRA 267
STKc_AMPK-like cd14003
Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze ...
24-312 7.70e-45

Catalytic domain of AMP-activated protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The AMPK-like subfamily is composed of AMPK, MARK, BRSK, NUAK, MELK, SNRK, TSSK, and SIK, among others. LKB1 serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. BRSKs play important roles in establishing neuronal polarity. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. The AMPK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270905 [Multi-domain]  Cd Length: 252  Bit Score: 154.21  E-value: 7.70e-45
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTL-REIKILLRFRHENIIGINDIIRAPtieqmKDVY 102
Cdd:cd14003   1 NYELGKTLGEGSFGKVKLARHKLTGEKVAIKIIDKSKLKEEIEEKIkREIEIMKLLNHPNIIKLYEVIETE-----NKIY 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLME-TDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHdh 180
Cdd:cd14003  76 LVMEYASgGELFDYIVNNgRLSEDEARRFFQQLISAVDYCHSNGIVHRDLKLENILLDKNGNLKIIDFGLSNEFRGGS-- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 tgFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhyldqlnhilgilgspSQEDLNCiINLKA 260
Cdd:cd14003 154 --LLKTFCGTPAYAAPEVLLGRKYDGPKADVWSLGVILYAMLTGYLPF-------------------DDDNDSK-LFRKI 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 261 RNYLLSLPhknkvpwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14003 212 LKGKYPIP-----------SHLSPDARDLIRRMLVVDPSKRITIEEILNHPW 252
STKc_MAPKKK cd06606
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase ...
24-313 2.09e-43

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein Kinase Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPKKKs (MKKKs or MAP3Ks) are also called MAP/ERK kinase kinases (MEKKs) in some cases. They phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. This subfamily is composed of the Apoptosis Signal-regulating Kinases ASK1 (or MAPKKK5) and ASK2 (or MAPKKK6), MEKK1, MEKK2, MEKK3, MEKK4, as well as plant and fungal MAPKKKs. Also included in this subfamily are the cell division control proteins Schizosaccharomyces pombe Cdc7 and Saccharomyces cerevisiae Cdc15. The MAPKKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270783 [Multi-domain]  Cd Length: 258  Bit Score: 150.75  E-value: 2.09e-43
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI--SPFEHQTYcQRTLREIKILLRFRHENIIGINDIiraptiEQMKDV 101
Cdd:cd06606   1 RWKKGELLGKGSFGSVYLALNLDTGELMAVKEVelSGDSEEEL-EALEREIRILSSLKHPNIVRYLGT------ERTENT 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVqdLME-------TDLYKllKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-RV 173
Cdd:cd06606  74 LNI--FLEyvpggslASLLK--KFGKLPEPVVRKYTRQILEGLEYLHSNGIVHRDIKGANILVDSDGVVKLADFGCAkRL 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 ADPdhDHTGFLTEYVATRWYRAPEIMlNSKGYTKSIDIWSVGCILAEMLSNRPIFPgkHYLDQ---LNHILGILGSPsqe 250
Cdd:cd06606 150 AEI--ATGEGTKSLRGTPYWMAPEVI-RGEGYGRAADIWSLGCTVIEMATGKPPWS--ELGNPvaaLFKIGSSGEPP--- 221
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 251 dlnciinlkarnyllSLPhknkvpwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06606 222 ---------------PIP-----------EHLSEEAKDFLRKCLQRDPKKRPTADELLQHPFL 258
STKc_Aurora cd14007
Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of ...
19-313 3.17e-42

Catalytic domain of the Serine/Threonine kinase, Aurora kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Yeast contains only one Aurora kinase while most higher eukaryotes have two. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2. Aurora-B is most active at the transition during metaphase to the end of mitosis. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270909 [Multi-domain]  Cd Length: 253  Bit Score: 147.62  E-value: 3.17e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  19 FDVGprytnlSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRT--LREIKILLRFRHENIIgindiiraptie 96
Cdd:cd14007   2 FEIG------KPLGKGKFGNVYLAREKKSGFIVALKVISKSQLQKSGLEHqlRREIEIQSHLRHPNIL------------ 63
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 QM-------KDVYIVQDLMET-DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICD 167
Cdd:cd14007  64 RLygyfedkKRIYLILEYAPNgELYKELKKQkRFDEKEAAKYIYQLALALDYLHSKNIIHRDIKPENILLGSNGELKLAD 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 168 FGLARVADPDHDHTgflteYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYldqlnhilgilgsp 247
Cdd:cd14007 144 FGWSVHAPSNRRKT-----FCGTLDYLPPE-MVEGKEYDYKVDIWSLGVLCYELLVGKPPFESKSH-------------- 203
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 248 sQEDLNCIINLKARnyllslphknkvpwnrlFPNADSK-ALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14007 204 -QETYKRIQNVDIK-----------------FPSSVSPeAKDLISKLLQKDPSKRLSLEQVLNHPWI 252
STKc_Nek cd08215
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; ...
24-313 4.14e-42

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek family is composed of 11 different mammalian members (Nek1-11) with similarity to the catalytic domain of Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants that were prevented from entering mitosis. Neks contain a conserved N-terminal catalytic domain and a more divergent C-terminal regulatory region of various sizes and structures. They are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270855 [Multi-domain]  Cd Length: 258  Bit Score: 147.61  E-value: 4.14e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGmvcSAY---DNVNKVRVAIKKIsPFEHQTYCQR--TLREIKILLRFRHENIIGINDiirapTIEQM 98
Cdd:cd08215   1 KYEKIRVIGKGSFG---SAYlvrRKSDGKLYVLKEI-DLSNMSEKEReeALNEVKLLSKLKHPNIVKYYE-----SFEEN 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVqdlME----TDLYKLLKTQ-----HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 169
Cdd:cd08215  72 GKLCIV---MEyadgGDLAQKIKKQkkkgqPFPEEQILDWFVQICLALKYLHSRKILHRDLKTQNIFLTKDGVVKLGDFG 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 170 LARVADPDHDhtgFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGilGSPSQ 249
Cdd:cd08215 149 ISKVLESTTD---LAKTVVGTPYYLSPEL-CENKPYNYKSDIWALGCVLYELCTLKHPFEANNLPALVYKIVK--GQYPP 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 250 edlnciinlkarnyllslphknkvpwnrlFPNADSKAL-DLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd08215 223 -----------------------------IPSQYSSELrDLVNSMLQKDPEKRPSANEILSSPFI 258
STKc_CDC2L6 cd07867
Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; STKs catalyze the ...
31-313 4.63e-42

Catalytic domain of Serine/Threonine Kinase, Cell Division Cycle 2-like 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDC2L6 is also called CDK8-like and was previously referred to as CDK11. However, this is a confusing nomenclature as CDC2L6 is distinct from CDC2L1, which is represented by the two protein products from its gene, called CDK11(p110) and CDK11(p58), as well as the caspase-processed CDK11(p46). CDK11(p110), CDK11(p58), and CDK11(p46)do not belong to this subfamily. CDC2L6 is an associated protein of Mediator, a multiprotein complex that provides a platform to connect transcriptional and chromatin regulators and cofactors, in order to activate and mediate RNA polymerase II transcription. CDC2L6 is localized mainly in the nucleus amd exerts an opposing effect to CDK8 in VP16-dependent transcriptional activation by being a negative regulator. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDC2L6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270850 [Multi-domain]  Cd Length: 318  Bit Score: 149.06  E-value: 4.63e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAY--DNVNKVRVAIKKIspfEHQTYCQRTLREIKILLRFRHENIIGINDIIRAptiEQMKDVYIVQDLM 108
Cdd:cd07867  10 VGRGTYGHVYKAKrkDGKDEKEYALKQI---EGTGISMSACREIALLRELKHPNVIALQKVFLS---HSDRKVWLLFDYA 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ETDLYKLLK----------TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL----NTTCDLKICDFGLARVA 174
Cdd:cd07867  84 EHDLWHIIKfhraskankkPMQLPRSMVKSLLYQILDGIHYLHANWVLHRDLKPANILVmgegPERGRVKIADMGFARLF 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 175 DPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH---------YLDQLNHILGILG 245
Cdd:cd07867 164 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFHCRQediktsnpfHHDQLDRIFSVMG 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 246 SPSQEDLNCIINLK--------------ARNYLLSLPHKNKVpwnrlfpNADSKALDLLDKMLTFNPHKRIEVEQALAHP 311
Cdd:cd07867 244 FPADKDWEDIRKMPeyptlqkdfrrttyANSSLIKYMEKHKV-------KPDSKVFLLLQKLLTMDPTKRITSEQALQDP 316

                ..
gi 66932916 312 YL 313
Cdd:cd07867 317 YF 318
STKc_CDK8 cd07868
Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8; STKs ...
31-313 7.93e-42

Catalytic domain of the Serine/Threonine Kinase, Cyclin-Dependent protein Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CDK8 can act as a negative or positive regulator of transcription, depending on the scenario. Together with its regulator, cyclin C, it reversibly associates with the multi-subunit core Mediator complex, a cofactor that is involved in regulating RNA polymerase II (RNAP II)-dependent transcription. CDK8 phosphorylates cyclin H, a subunit of the general transcription factor TFIIH, which results in the inhibition of TFIIH-dependent phosphorylation of the C-terminal domain of RNAP II, facilitating the inhibition of transcription. It has also been shown to promote transcription by a mechanism that is likely to involve RNAP II phosphorylation. CDK8 also functions as a stimulus-specific positive coregulator of p53 transcriptional responses. CDKs belong to a large family of STKs that are regulated by their cognate cyclins. Together, they are involved in the control of cell-cycle progression, transcription, and neuronal function. The CDK8 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270851 [Multi-domain]  Cd Length: 333  Bit Score: 149.05  E-value: 7.93e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAY--DNVNKVRVAIKKIspfEHQTYCQRTLREIKILLRFRHENIIGINDIIRAptiEQMKDVYIVQDLM 108
Cdd:cd07868  25 VGRGTYGHVYKAKrkDGKDDKDYALKQI---EGTGISMSACREIALLRELKHPNVISLQKVFLS---HADRKVWLLFDYA 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ETDLYKLLKTQHLSNDH----------ICYFLYQILRGLKYIHSANVLHRDLKPSNLLL----NTTCDLKICDFGLARVA 174
Cdd:cd07868  99 EHDLWHIIKFHRASKANkkpvqlprgmVKSLLYQILDGIHYLHANWVLHRDLKPANILVmgegPERGRVKIADMGFARLF 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 175 DPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF---------PGKHYLDQLNHILGILG 245
Cdd:cd07868 179 NSPLKPLADLDPVVVTFWYRAPELLLGARHYTKAIDIWAIGCIFAELLTSEPIFhcrqediktSNPYHHDQLDRIFNVMG 258
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 246 SPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFP-------NADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd07868 259 FPADKDWEDIKKMPEHSTLMKDFRRNTYTNCSLIKymekhkvKPDSKAFHLLQKLLTMDPIKRITSEQAMQDPYF 333
STKc_ATG1_ULK_like cd14009
Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like ...
31-312 1.40e-40

Catalytic domain of the Serine/Threonine kinases, Autophagy-related protein 1 and Unc-51-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes yeast ATG1 and metazoan homologs including vertebrate ULK1-3. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. It is involved in nutrient sensing and signaling, the assembly of autophagy factors and the execution of autophagy. In metazoans, ATG1 homologs display additional functions. Unc-51 and ULKs have been implicated in neuronal and axonal development. The ATG1/ULK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270911 [Multi-domain]  Cd Length: 251  Bit Score: 143.13  E-value: 1.40e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTL-REIKILLRFRHENIIGINDIIRAPTieqmkDVYIVqdlME 109
Cdd:cd14009   1 IGRGSFATVWKGRHKQTGEVVAIKEISRKKLNKKLQENLeSEIAILKSIKHPNIVRLYDVQKTED-----FIYLV---LE 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 ----TDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFGLARvadpdHDHT 181
Cdd:cd14009  73 ycagGDLSQYIRKrGRLPEAVARHFMQQLASGLKFLRSKNIIHRDLKPQNLLLSTSGDdpvLKIADFGFAR-----SLQP 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLTEYV-ATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNhilgilgspsqedlnciiNLKA 260
Cdd:cd14009 148 ASMAETLcGSPLYMAPEI-LQFQKYDAKADLWSVGAILFEMLVGKPPFRGSNHVQLLR------------------NIER 208
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 261 RNYLLSLPhknkvpwnrLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14009 209 SDAVIPFP---------IAAQLSPDCKDLLRRLLRRDPAERISFEEFFAHPF 251
STKc_Cdc7 cd14019
Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze ...
25-313 4.69e-40

Catalytic domain of the Serine/Threonine Kinase, Cell Division Cycle 7 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Cdc7 kinase (or Hsk1 in fission yeast) is a critical regulator in the initiation of DNA replication. It forms a complex with a Dbf4-related regulatory subunit, a cyclin-like molecule that activates the kinase in late G1 phase, and is also referred to as Dbf4-dependent kinase (DDK). Its main targets are mini-chromosome maintenance (MCM) proteins. Cdc7 kinase may also have additional roles in meiosis, checkpoint responses, the maintenance and repair of chromosome structures, and cancer progression. The Cdc7 kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270921 [Multi-domain]  Cd Length: 252  Bit Score: 141.98  E-value: 4.69e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSA-------YDNVNKVRVAIKKISPFEHQtycQRTLREIKILLRFR-HENIIGINDIIRAptie 96
Cdd:cd14019   3 YRIIEKIGEGTFSSVYKAedklhdlYDRNKGRLVALKHIYPTSSP---SRILNELECLERLGgSNNVSGLITAFRN---- 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 qmKD-VYIVQDLME----TDLYKllktqHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGL 170
Cdd:cd14019  76 --EDqVVAVLPYIEhddfRDFYR-----KMSLTDIRIYLRNLFKALKHVHSFGIIHRDVKPGNFLYNrETGKGVLVDFGL 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 171 ARVAdpdHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHILGILGSPSq 249
Cdd:cd14019 149 AQRE---EDRPEQRAPRAGTRGFRAPEVLFKCPHQTTAIDIWSAGVILLSILSgRFPFFFSSDDIDALAEIATIFGSDE- 224
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916 250 edlnciinlkarnyllslphknkvpwnrlfpnadskALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14019 225 ------------------------------------AYDLLDKLLELDPSKRITAEEALKHPFF 252
STKc_PAK cd06614
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the ...
25-314 4.80e-40

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. PAK deregulation is associated with tumor development. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). Group II PAKs contain a PBD and a catalytic domain, but lack other motifs found in group I PAKs. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. Group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX; no such binding has been demonstrated for group II PAKs. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270789 [Multi-domain]  Cd Length: 255  Bit Score: 141.96  E-value: 4.80e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYcQRTLREIKILLRFRHENIIGINDiirapTIEQMKDVYIV 104
Cdd:cd06614   2 YKNLEKIGEGASGEVYKATDRATGKEVAIKKMR-LRKQNK-ELIINEILIMKECKHPNIVDYYD-----SYLVGDELWVV 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLME----TDLYkllkTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPD 177
Cdd:cd06614  75 MEYMDggslTDII----TQNpvrMNESQIAYVCREVLQGLEYLHSQNVIHRDIKSDNILLSKDGSVKLADFGFAAQLTKE 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HDHTgflTEYVATRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPifPgkhYLDQlnhilgilgSPsqedlnciin 257
Cdd:cd06614 151 KSKR---NSVVGTPYWMAPEVIK-RKDYGPKVDIWSLGIMCIEMAEGEP--P---YLEE---------PP---------- 202
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 258 LKARnYLLS---LPH-KNKVPWNRLFpnadskaLDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd06614 203 LRAL-FLITtkgIPPlKNPEKWSPEF-------KDFLNKCLVKDPEKRPSAEELLQHPFLK 255
PKc_DYRK1 cd14226
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
24-315 5.03e-40

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. Mammals contain two types of DYRK1 proteins, DYRK1A and DYRK1B. DYRK1A was previously called minibrain kinase homolog (MNBH) or dual-specificity YAK1-related kinase. It phosphorylates various substrates and is involved in many cellular events. It phosphorylates and inhibits the transcription factors, nuclear factor of activated T cells (NFAT) and forkhead in rhabdomyosarcoma (FKHR). It regulates neuronal differentiation by targetting CREB (cAMP response element-binding protein). It also targets many endocytic proteins including dynamin and amphiphysin and may play a role in the endocytic pathway. The gene encoding DYRK1A is located in the DSCR (Down syndrome critical region) of human chromosome 21 and DYRK1A has been implicated in the pathogenesis of DS. DYRK1B, also called minibrain-related kinase (MIRK), is highly expressed in muscle and plays a critical role in muscle differentiation by regulating transcription, cell motility, survival, and cell cycle progression. It is overexpressed in many solid tumors where it acts as a tumor survival factor. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. The DYRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271128 [Multi-domain]  Cd Length: 339  Bit Score: 144.38  E-value: 5.03e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI---SPFEHQTycqrtLREIKILLRFRHENIIGINDIIRaptieqMKD 100
Cdd:cd14226  14 RYEIDSLIGKGSFGQVVKAYDHVEQEWVAIKIIknkKAFLNQA-----QIEVRLLELMNKHDTENKYYIVR------LKR 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VY-------IVQDLMETDLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSA--NVLHRDLKPSNLLLNTT--CDLKIC 166
Cdd:cd14226  83 HFmfrnhlcLVFELLSYNLYDLLRNTNfrgVSLNLTRKFAQQLCTALLFLSTPelSIIHCDLKPENILLCNPkrSAIKII 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 167 DFGLARvadpdhdHTG-FLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILG 245
Cdd:cd14226 163 DFGSSC-------QLGqRIYQYIQSRFYRSPEVLLGLP-YDLAIDMWSLGCILVEMHTGEPLFSGANEVDQMNKIVEVLG 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 246 SPSQEDLNciINLKARNYLLSLP------------HKNKVP-----------------WNRLFPNADS-----KALDLLD 291
Cdd:cd14226 235 MPPVHMLD--QAPKARKFFEKLPdgtyylkktkdgKKYKPPgsrklheilgvetggpgGRRAGEPGHTvedylKFKDLIL 312
                       330       340
                ....*....|....*....|....
gi 66932916 292 KMLTFNPHKRIEVEQALAHPYLEQ 315
Cdd:cd14226 313 RMLDYDPKTRITPAEALQHSFFKR 336
STKc_MAP3K-like cd13999
Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine ...
31-234 6.79e-40

Catalytic domain of Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed mainly of MAP3Ks and similar proteins, including TGF-beta Activated Kinase-1 (TAK1, also called MAP3K7), MAP3K12, MAP3K13, Mixed lineage kinase (MLK), MLK-Like mitogen-activated protein Triple Kinase (MLTK), and Raf (Rapidly Accelerated Fibrosarcoma) kinases. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Also included in this subfamily is the pseudokinase Kinase Suppressor of Ras (KSR), which is a scaffold protein that functions downstream of Ras and upstream of Raf in the Extracellular signal-Regulated Kinase (ERK) pathway.


Pssm-ID: 270901 [Multi-domain]  Cd Length: 245  Bit Score: 141.14  E-value: 6.79e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVrvAIKKISPFEHQTYCQRT-LREIKILLRFRHENI---IGINdiiraptiEQMKDVYIVQD 106
Cdd:cd13999   1 IGSGSFGEVYKGKWRGTDV--AIKKLKVEDDNDELLKEfRREVSILSKLRHPNIvqfIGAC--------LSPPPLCIVTE 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LME-TDLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV-ADPDHDHTG 182
Cdd:cd13999  71 YMPgGSLYDLLHKKkiPLSWSLRLKIALDIARGMNYLHSPPIIHRDLKSLNILLDENFTVKIADFGLSRIkNSTTEKMTG 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 183 FLTEYvatRWyRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 234
Cdd:cd13999 151 VVGTP---RW-MAPEV-LRGEPYTEKADVYSFGIVLWELLTGEVPFKELSPI 197
PKc_DYRK4 cd14225
Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and ...
24-313 6.76e-38

Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 4; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. DYRK4 is a testis-specific kinase with restricted expression to postmeiotic spermatids. It may function during spermiogenesis, however, it is not required for male fertility. DYRK4 has also been detected in a human teratocarcinoma cell line induced to produce postmitotic neurons. It may have a role in neuronal differentiation. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. They play important roles in cell proliferation, differentiation, survival, and development. The DYRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271127 [Multi-domain]  Cd Length: 341  Bit Score: 138.68  E-value: 6.76e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI---SPFEHQTycqrtLREIKILLRFRHENIIGINDIIraptieQMKD 100
Cdd:cd14225  44 RYEILEVIGKGSFGQVVKALDHKTNEHVAIKIIrnkKRFHHQA-----LVEVKILDALRRKDRDNSHNVI------HMKE 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VY-------IVQDLMETDLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT--TCDLKICDF 168
Cdd:cd14225 113 YFyfrnhlcITFELLGMNLYELIKKnnfQGFSLSLIRRFAISLLQCLRLLYRERIIHCDLKPENILLRQrgQSSIKVIDF 192
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 169 GlarvaDPDHDHTGFLTeYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPS 248
Cdd:cd14225 193 G-----SSCYEHQRVYT-YIQSRFYRSPEVILGLP-YSMAIDMWSLGCILAELYTGYPLFPGENEVEQLACIMEVLGLPP 265
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 249 QEDLN----------------CIINLKARNYllslpHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14225 266 PELIEnaqrrrlffdskgnprCITNSKGKKR-----RPNSKDLASALKTSDPLFLDFIRRCLEWDPSKRMTPDEALQHEW 340

                .
gi 66932916 313 L 313
Cdd:cd14225 341 I 341
STKc_PLK cd14099
Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the ...
24-313 7.09e-38

Catalytic domain of the Serine/Threonine Kinases, Polo-like kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. PLKs derive their names from homology to polo, a kinase first identified in Drosophila. There are five mammalian PLKs (PLK1-5) from distinct genes. There is good evidence that PLK1 may function as an oncogene while PLK2-5 have tumor suppressive properties. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. PLK2 functions in G1 progression, S-phase arrest, and centriole duplication. PLK3 regulates angiogenesis and responses to DNA damage. PLK4 is required for late mitotic progression, cell survival, and embryonic development. PLK5 was first identified as a pseudogene containing a stop codon within the kinase domain, however, both murine and human genes encode expressed proteins. PLK5 functions in cell cycle arrest.


Pssm-ID: 271001 [Multi-domain]  Cd Length: 258  Bit Score: 136.14  E-value: 7.09e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISP----FEHQTycQRTLREIKILLRFRHENIIGINDiirapTIEQMK 99
Cdd:cd14099   2 RYRRGKFLGKGGFAKCYEVTDMSTGKVYAGKVVPKssltKPKQR--EKLKSEIKIHRSLKHPNIVKFHD-----CFEDEE 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 DVYIV------QDLMEtdlykLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR 172
Cdd:cd14099  75 NVYILlelcsnGSLME-----LLKRRKaLTEPEVRYFMRQILSGVKYLHSNRIIHRDLKLGNLFLDENMNVKIGDFGLAA 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 VADPDHDHTGFLteyVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqedl 252
Cdd:cd14099 150 RLEYDGERKKTL---CGTPNYIAPEVLEKKKGHSFEVDIWSLGVILYTLLVGKPPFETSDVKETYKRI------------ 214
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 253 nciinlKARNYllSLPHKNKVPwnrlfpnadSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14099 215 ------KKNEY--SFPSHLSIS---------DEAKDLIRSMLQPDPTKRPSLDEILSHPFF 258
STKc_Chk1 cd14069
Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the ...
31-313 1.21e-37

Catalytic domain of the Serine/Threonine kinase, Checkpoint kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chk1 is implicated in many major checkpoints of the cell cycle, providing a link between upstream sensors and the cell cycle engine. It plays an important role in DNA damage response and maintaining genomic stability. Chk1 acts as an effector of the sensor kinase, ATR (ATM and Rad3-related), a member of the PI3K family, which is activated upon DNA replication stress. Chk1 delays mitotic entry in response to replication blocks by inhibiting cyclin dependent kinase (Cdk) activity. In addition, Chk1 contributes to the function of centrosome and spindle-based checkpoints, inhibits firing of origins of DNA replication (Ori), and represses transcription of cell cycle proteins including cyclin B and Cdk1. The Chk1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270971 [Multi-domain]  Cd Length: 261  Bit Score: 135.92  E-value: 1.21e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLR-EIKILLRFRHENIIGINDIIRAPTIEqmkdvYIVQDLME 109
Cdd:cd14069   9 LGEGAFGEVFLAVNRNTEEAVAVKFVDMKRAPGDCPENIKkEVCIQKMLSHKNVVRFYGHRREGEFQ-----YLFLEYAS 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 T-DLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDhDHTGFLTEY 187
Cdd:cd14069  84 GgELFdKIEPDVGMPEDVAQFYFQQLMAGLKYLHSCGITHRDIKPENLLLDENDNLKISDFGLATVFRYK-GKERLLNKM 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 188 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSnrpifpGKHYLDQlnhilgilgsPSQedlNCIINLKARNYLLSL 267
Cdd:cd14069 163 CGTLPYVAPELLAKKKYRAEPVDVWSCGIVLFAMLA------GELPWDQ----------PSD---SCQEYSDWKENKKTY 223
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 66932916 268 PHknkvPWNRLfpnaDSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14069 224 LT----PWKKI----DTAALSLLRKILTENPNKRITIEDIKKHPWY 261
PKc_YAK1 cd14212
Catalytic domain of the Dual-specificity protein kinase, YAK1; Dual-specificity PKs catalyze ...
25-313 1.48e-37

Catalytic domain of the Dual-specificity protein kinase, YAK1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of proteins with similarity to Saccharomyces cerevisiae YAK1 (or Yak1p), a dual-specificity kinase that autophosphorylates at tyrosine residues and phosphorylates substrates on S/T residues. YAK1 phosphorylates and activates the transcription factors Hsf1 and Msn2, which play important roles in cellular homeostasis during stress conditions including heat shock, oxidative stress, and nutrient deficiency. It also phosphorylates the protein POP2, a component of a complex that regulates transcription, under glucose-deprived conditions. It functions as a part of a glucose-sensing system that is involved in controlling growth in yeast. The YAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271114 [Multi-domain]  Cd Length: 330  Bit Score: 137.38  E-value: 1.48e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpfEHQTYCQRTLREIKILLRFRheNIIGIND---IIRaptieqMKDV 101
Cdd:cd14212   1 YLVLDLLGQGTFGQVVKCQDLKTNKLVAVKVLK--NKPAYFRQAMLEIAILTLLN--TKYDPEDkhhIVR------LLDH 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 Y-------IVQDLMETDLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL--NTTCDLKICDFG 169
Cdd:cd14212  71 FmhhghlcIVFELLGVNLYELLKQNQfrgLSLQLIRKFLQQLLDALSVLKDARIIHCDLKPENILLvnLDSPEIKLIDFG 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 170 LArvadPDHDHTgfLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ 249
Cdd:cd14212 151 SA----CFENYT--LYTYIQSRFYRSPEVLLGLP-YSTAIDMWSLGCIAAELFLGLPLFPGNSEYNQLSRIIEMLGMPPD 223
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 250 EDL------NCIINLKARNY------LLSL------------PHKNKVPWNRL--------FPNADSKA----------- 286
Cdd:cd14212 224 WMLekgkntNKFFKKVAKSGgrstyrLKTPeefeaenncklePGKRYFKYKTLediimnypMKKSKKEQidkemetrlaf 303
                       330       340
                ....*....|....*....|....*..
gi 66932916 287 LDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14212 304 IDFLKGLLEYDPKKRWTPDQALNHPFI 330
PKc_CLK cd14134
Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases; Dual-specificity ...
16-313 4.08e-37

Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. CLKs are involved in the phosphorylation and regulation of serine/arginine-rich (SR) proteins, which play a crucial role in pre-mRNA splicing by directing splice site selection. SR proteins are phosphorylated first by SR protein kinases (SRPKs) at the N-terminus, which leads to its assembly into nuclear speckles where splicing factors are stored. CLKs phosphorylate the C-terminal part of SR proteins, causing the nuclear speckles to dissolve and splicing factors to be recruited at sites of active transcription. Based on a conserved "EHLAMMERILG" signature motif which may be crucial for substrate specificity, CLKs are also referred to as LAMMER kinases. CLKs autophosphorylate at tyrosine residues and phosphorylate their substrates exclusively on S/T residues. In Drosophila, the CLK homolog DOA (Darkener of apricot) is essential for embryogenesis and its mutation leads to defects in sexual differentiation, eye formation, and neuronal development. In fission yeast, the CLK homolog Lkh1 is a negative regulator of filamentous growth and asexual flocculation, and is also involved in oxidative stress response. Vertebrates contain mutliple CLK proteins and mammals have four (CLK1-4). The CLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271036 [Multi-domain]  Cd Length: 332  Bit Score: 136.16  E-value: 4.08e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  16 GQVFDvgPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFehQTYCQRTLREIKILLRFRHENIIGINDIIrapti 95
Cdd:cd14134   7 GDLLT--NRYKILRLLGEGTFGKVLECWDRKRKRYVAVKIIRNV--EKYREAAKIEIDVLETLAEKDPNGKSHCV----- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  96 eQMKD-------VYIVQDLMETDLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL--NTT--- 160
Cdd:cd14134  78 -QLRDwfdyrghMCIVFELLGPSLYDFLKKNNygpFPLEHVQHIAKQLLEAVAFLHDLKLTHTDLKPENILLvdSDYvkv 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 161 --------------CDLKICDFGLARVadpDHDHTGFLteyVATRWYRAPEIMLNSkGYTKSIDIWSVGCILAEMLSNRP 226
Cdd:cd14134 157 ynpkkkrqirvpksTDIKLIDFGSATF---DDEYHSSI---VSTRHYRAPEVILGL-GWSYPCDVWSIGCILVELYTGEL 229
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 227 IFPGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYllslPHKNKVPWN----------------RLFPNADSK----A 286
Cdd:cd14134 230 LFQTHDNLEHLAMMERILGPLPKRMIRRAKKGAKYFY----FYHGRLDWPegsssgrsikrvckplKRLMLLVDPehrlL 305
                       330       340
                ....*....|....*....|....*..
gi 66932916 287 LDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14134 306 FDLIRKMLEYDPSKRITAKEALKHPFF 332
STYKc smart00221
Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class ...
26-224 8.76e-37

Protein kinase; unclassified specificity; Phosphotransferases. The specificity of this class of kinases can not be predicted. Possible dual-specificity Ser/Thr/Tyr kinase.


Pssm-ID: 214568 [Multi-domain]  Cd Length: 258  Bit Score: 133.44  E-value: 8.76e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916     26 TNLSYIGEGAYGMVCSAY----DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENII---GIndiiraptIEQM 98
Cdd:smart00221   2 TLGKKLGEGAFGEVYKGTlkgkGDGKEVEVAVKTLKEDASEQQIEEFLREARIMRKLDHPNIVkllGV--------CTEE 73
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916     99 KDVYIVQDLMET-DLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVA 174
Cdd:smart00221  74 EPLMIVMEYMPGgDLLDYLRKNRpkeLSLSDLLSFALQIARGMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRDL 153
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|
gi 66932916    175 DPDHDHTGFLTEyVATRWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLSN 224
Cdd:smart00221 154 YDDDYYKVKGGK-LPIRWM-APESLKEGKFTSKS-DVWSFGVLLWEIFTL 200
STKc_LKB1_CaMKK cd14008
Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent ...
31-313 1.23e-36

Catalytic domain of the Serine/Threonine kinases, Liver Kinase B1, Calmodulin Dependent Protein Kinase Kinase, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Both LKB1 and CaMKKs can phosphorylate and activate AMP-activated protein kinase (AMPK). LKB1, also called STK11, serves as a master upstream kinase that activates AMPK and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMPK. Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The LKB1/CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270910 [Multi-domain]  Cd Length: 267  Bit Score: 133.45  E-value: 1.23e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIS-------------PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPtieQ 97
Cdd:cd14008   1 LGRGSFGKVKLALDTETGQLYAIKIFNksrlrkrregkndRGKIKNALDDVRREIAIMKKLDHPNIVRLYEVIDDP---E 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  98 MKDVYIVQDLMET-DLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV 173
Cdd:cd14008  78 SDKLYLVLEYCEGgPVMELDSGDRvppLPEETARKYFRDLVLGLEYLHENGIVHRDIKPENLLLTADGTVKISDFGVSEM 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 ADPDhdhTGFLTEYVATRWYRAPEIML-NSKGY-TKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqed 251
Cdd:cd14008 158 FEDG---NDTLQKTAGTPAFLAPELCDgDSKTYsGKAADIWALGVTLYCLVFGRLPFNGDNILELYEAI----------- 223
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 252 lnciinlkarnyllsLPHKNKVPWnrlfPNADSKAL-DLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14008 224 ---------------QNQNDEFPI----PPELSPELkDLLRRMLEKDPEKRITLKEIKEHPWV 267
STKc_AGC cd05123
Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the ...
31-312 2.32e-36

Catalytic domain of AGC family Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AGC kinases regulate many cellular processes including division, growth, survival, metabolism, motility, and differentiation. Many are implicated in the development of various human diseases. Members of this family include cAMP-dependent Protein Kinase (PKA), cGMP-dependent Protein Kinase (PKG), Protein Kinase C (PKC), Protein Kinase B (PKB), G protein-coupled Receptor Kinase (GRK), Serum- and Glucocorticoid-induced Kinase (SGK), and 70 kDa ribosomal Protein S6 Kinase (p70S6K or S6K), among others. AGC kinases share an activation mechanism based on the phosphorylation of up to three sites: the activation loop (A-loop), the hydrophobic motif (HM) and the turn motif. Phosphorylation at the A-loop is required of most AGC kinases, which results in a disorder-to-order transition of the A-loop. The ordered conformation results in the access of substrates and ATP to the active site. A subset of AGC kinases with C-terminal extensions containing the HM also requires phosphorylation at this site. Phosphorylation at the HM allows the C-terminal extension to form an ordered structure that packs into the hydrophobic pocket of the catalytic domain, which then reconfigures the kinase into an active bi-lobed state. In addition, growth factor-activated AGC kinases such as PKB, p70S6K, RSK, MSK, PKC, and SGK, require phosphorylation at the turn motif (also called tail or zipper site), located N-terminal to the HM at the C-terminal extension. The AGC family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and Phosphoinositide 3-Kinase.


Pssm-ID: 270693 [Multi-domain]  Cd Length: 250  Bit Score: 132.26  E-value: 2.32e-36
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQ--RTLREIKILLRFRHENIIGIndiirAPTIEQMKDVYIVQDLM 108
Cdd:cd05123   1 LGKGSFGKVLLVRKKDTGKLYAMKVLRKKEIIKRKEveHTLNERNILERVNHPFIVKL-----HYAFQTEEKLYLVLDYV 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgflTE 186
Cdd:cd05123  76 PGgELFSHLSKEGrFPEERARFYAAEIVLALEYLHSLGIIYRDLKPENILLDSDGHIKLTDFGLAKELSSDGDRT---YT 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 187 YVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPgkhyldqlnhilgilGSPSQEDLNCIINLKarnylLS 266
Cdd:cd05123 153 FCGTPEYLAPEV-LLGKGYGKAVDWWSLGVLLYEMLTGKPPFY---------------AENRKEIYEKILKSP-----LK 211
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 267 LPhknkvpwnrlfPNADSKALDLLDKMLTFNPHKRI---EVEQALAHPY 312
Cdd:cd05123 212 FP-----------EYVSPEAKSLISGLLQKDPTKRLgsgGAEEIKAHPF 249
TyrKc smart00219
Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.
26-224 2.71e-36

Tyrosine kinase, catalytic domain; Phosphotransferases. Tyrosine-specific kinase subfamily.


Pssm-ID: 197581 [Multi-domain]  Cd Length: 257  Bit Score: 132.27  E-value: 2.71e-36
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916     26 TNLSYIGEGAYGMVCSA-YDNVN---KVRVAIKKISpfEHQTYCQRT--LREIKILLRFRHENII---GIndiiraptIE 96
Cdd:smart00219   2 TLGKKLGEGAFGEVYKGkLKGKGgkkKVEVAVKTLK--EDASEQQIEefLREARIMRKLDHPNVVkllGV--------CT 71
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916     97 QMKDVYIVQDLMET-DLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV 173
Cdd:smart00219  72 EEEPLYIVMEYMEGgDLLSYLRKNrpKLSLSDLLSFALQIARGMEYLESKNFIHRDLAARNCLVGENLVVKISDFGLSRD 151
                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|.
gi 66932916    174 ADpDHDHTGFLTEYVATRWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLSN 224
Cdd:smart00219 152 LY-DDDYYRKRGGKLPIRWM-APESLKEGKFTSKS-DVWSFGVLLWEIFTL 199
STKc_TSSK-like cd14080
Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs ...
31-313 1.52e-35

Catalytic domain of testis-specific serine/threonine kinases and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. TSSK6, also called SSTK, is expressed at the head of elongated sperm. TSSK1/TSSK2 double knock-out and TSSK6 null mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270982 [Multi-domain]  Cd Length: 262  Bit Score: 130.38  E-value: 1.52e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAY--DNVNKVRVAIK----KISPFEhqtYCQRTL-REIKILLRFRHENIIGINDIIraptiEQMKDVYI 103
Cdd:cd14080   8 IGEGSYSKVKLAEytKSGLKEKVACKiidkKKAPKD---FLEKFLpRELEILRKLRHPNIIQVYSIF-----ERGSKVFI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLME-TDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAdPDHDHT 181
Cdd:cd14080  80 FMEYAEhGDLLEYIQKRgALSESQARIWFRQLALAVQYLHSLDIAHRDLKCENILLDSNNNVKLSDFGFARLC-PDDDGD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLTEYVATRWYRAPEImLNSKGYT-KSIDIWSVGCILAEMLSNRPIFPGKH----YLDQLNHILGIlgSPSQEDLNcii 256
Cdd:cd14080 159 VLSKTFCGSAAYAAPEI-LQGIPYDpKKYDIWSLGVILYIMLCGSMPFDDSNikkmLKDQQNRKVRF--PSSVKKLS--- 232
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 257 nlkarnyllslphknkvpwnrlfpnadSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14080 233 ---------------------------PECKDLIDQLLEPDPTKRATIEEILNHPWL 262
STKc_STK36 cd14002
Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the ...
24-313 3.26e-35

Catalytic domain of Serine/Threonine Kinase 36; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK36, also called Fused (or Fu) kinase, is involved in the Hedgehog signaling pathway. It is activated by the Smoothened (SMO) signal transducer, resulting in the stabilization of GLI transcription factors and the phosphorylation of SUFU to facilitate the nuclear accumulation of GLI. In Drosophila, Fused kinase is maternally required for proper segmentation during embryonic development and for the development of legs and wings during the larval stage. In mice, STK36 is not necessary for embryonic development, although mice deficient in STK36 display growth retardation postnatally. The STK36 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270904 [Multi-domain]  Cd Length: 253  Bit Score: 129.29  E-value: 3.26e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLR-EIKILLRFRHENIIGINDiirapTIEQMKDVY 102
Cdd:cd14002   2 NYHVLELIGEGSFGKVYKGRRKYTGQVVALKFIPKRGKSEKELRNLRqEIEILRKLNHPNIIEMLD-----SFETKKEFV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDhdhT 181
Cdd:cd14002  77 VVTEYAQGELFQILEDDGtLPEEEVRSIAKQLVSALHYLHSNRIIHRDMKPQNILIGKGGVVKLCDFGFARAMSCN---T 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsqedlnciinlkar 261
Cdd:cd14002 154 LVLTSIKGTPLYMAPEL-VQEQPYDHTADLWSLGCILYELFVGQPPFYTNSIYQLVQMIV-------------------- 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 262 nyllslphKNKVPWNrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14002 213 --------KDPVKWP---SNMSPEFKSFLQGLLNKDPSKRLSWPDLLEHPFV 253
STKc_PRP4 cd14135
Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze ...
24-313 5.62e-35

Catalytic domain of the Serine/Threonine Kinase, Pre-mRNA-Processing factor 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PRP4 phosphorylates a number of factors involved in the formation of active spliceosomes, which catalyze pre-mRNA splicing. It phosphorylates PRP6 and PRP31, components of the U4/U6-U5 tri-small nuclear ribonucleoprotein (snRNP), during spliceosomal complex formation. In fission yeast, PRP4 phosphorylates the splicing factor PRP1 (U5-102 kD in mammals). Thus, PRP4 plays a key role in regulating spliceosome assembly and pre-mRNA splicing. It also plays an important role in mitosis by acting as a spindle assembly checkpoint kinase that is required for chromosome alignment and the recruitment of the checkpoint proteins MPS1, MAD1, and MAD2 at kinetochores. The PRP4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271037 [Multi-domain]  Cd Length: 318  Bit Score: 130.42  E-value: 5.62e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYD--NVNKVrVAIKKISPFEhqTYCQRTLREIKILLRFRHENIIGINDIIR-APTIEQMKD 100
Cdd:cd14135   1 RYRVYGYLGKGVFSNVVRARDlaRGNQE-VAIKIIRNNE--LMHKAGLKELEILKKLNDADPDDKKHCIRlLRHFEHKNH 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLMETDLYKLLK----TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLARvad 175
Cdd:cd14135  78 LCLVFESLSMNLREVLKkygkNVGLNIKAVRSYAQQLFLALKHLKKCNILHADIKPDNILVNeKKNTLKLCDFGSAS--- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 pdHDHTGFLTEYVATRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQ------ 249
Cdd:cd14135 155 --DIGENEITPYLVSRFYRAPEIIL-GLPYDYPIDMWSVGCTLYELYTGKILFPGKTNNHMLKLMMDLKGKFPKkmlrkg 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 250 --------EDLNCI------INLKARNYLLSLPHKNKVPWNRLFPNADSKA---------LDLLDKMLTFNPHKRIEVEQ 306
Cdd:cd14135 232 qfkdqhfdENLNFIyrevdkVTKKEVRRVMSDIKPTKDLKTLLIGKQRLPDedrkkllqlKDLLDKCLMLDPEKRITPNE 311

                ....*..
gi 66932916 307 ALAHPYL 313
Cdd:cd14135 312 ALQHPFI 318
STKc_RSK_C cd14091
C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs ...
71-316 7.37e-35

C-terminal catalytic domain of the Serine/Threonine Kinases, Ribosomal S6 kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), 90 kDa ribosomal protein S6 kinases (p90-RSKs), or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270993 [Multi-domain]  Cd Length: 291  Bit Score: 129.29  E-value: 7.37e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  71 EIKILLRF-RHENIIGINDIIraptiEQMKDVYIVQDLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLH 147
Cdd:cd14091  43 EIEILLRYgQHPNIITLRDVY-----DDGNSVYLVTELLRGGelLDRILRQKFFSEREASAVMKTLTKTVEYLHSQGVVH 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 148 RDLKPSNLLL-NTTCD---LKICDFGLARVADPDHdhtGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd14091 118 RDLKPSNILYaDESGDpesLRICDFGFAKQLRAEN---GLLMTPCYTANFVAPEV-LKKQGYDAACDIWSLGVLLYTMLA 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 224 NRPIF---PGkhylDQLNHILGILGSpsqedlnciinlkarnYLLSLPHKNkvpWNrlfpNADSKALDLLDKMLTFNPHK 300
Cdd:cd14091 194 GYTPFasgPN----DTPEVILARIGS----------------GKIDLSGGN---WD----HVSDSAKDLVRKMLHVDPSQ 246
                       250
                ....*....|....*.
gi 66932916 301 RIEVEQALAHPYLEQY 316
Cdd:cd14091 247 RPTAAQVLQHPWIRNR 262
PKc_DYRK2_3 cd14224
Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and ...
24-313 3.53e-34

Catalytic domain of the protein kinases, Dual-specificity tYrosine-phosphorylated and -Regulated Kinases 2 and 3; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (S/T) as well as tyrosine residues on protein substrates. This subfamily is composed of DYRK2 and DYRK3, and similar proteins. Drosophila DYRK2 interacts and phosphorylates the chromatin remodelling factor, SNR1 (Snf5-related 1), and also interacts with the essential chromatin component, trithorax. It may play a role in chromatin remodelling. Vertebrate DYRK2 phosphorylates and regulates the tumor suppressor p53 to induce apoptosis in response to DNA damage. It can also phosphorylate the transcription factor, nuclear factor of activated T cells (NFAT). DYRK2 is overexpressed in lung adenocarcinoma and esophageal carcinomas, and is a predictor for favorable prognosis in lung adenocarcinoma. DYRK3, also called regulatory erythroid kinase (REDK), is highly expressed in erythroid cells and the testis, and is also present in adult kidney and liver. It promotes cell survival by phosphorylating and activating SIRT1, an NAD(+)-dependent protein deacetylase, which promotes p53 deacetylation, resulting in the inhibition of apoptosis. DYRKs autophosphorylate themselves on tyrosine residues and phosphorylate their substrates exclusively on S/T residues. The DYRK2/3 subfamily is part of a larger superfamily that includes the catalytic domains of other S/T kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271126 [Multi-domain]  Cd Length: 380  Bit Score: 129.48  E-value: 3.53e-34
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKD-VY 102
Cdd:cd14224  66 RYEVLKVIGKGSFGQVVKAYDHKTHQHVALKMVR--NEKRFHRQAAEEIRILEHLKKQDKDNTMNVIHMLESFTFRNhIC 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT--CDLKICDFGlarvaDPD 177
Cdd:cd14224 144 MTFELLSMNLYELIKKnkfQGFSLQLVRKFAHSILQCLDALHRNKIIHCDLKPENILLKQQgrSGIKVIDFG-----SSC 218
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HDHTGFLTeYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNciIN 257
Cdd:cd14224 219 YEHQRIYT-YIQSRFYRAPEVILGAR-YGMPIDMWSFGCILAELLTGYPLFPGEDEGDQLACMIELLGMPPQKLLE--TS 294
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 258 LKARNYLLSLPH----------------------KNKV---PWNRLFPNA-----DSKALDLLDKMLTFNPHKRIEVEQA 307
Cdd:cd14224 295 KRAKNFISSKGYpryctvttlpdgsvvlnggrsrRGKMrgpPGSKDWVTAlkgcdDPLFLDFLKRCLEWDPAARMTPSQA 374

                ....*.
gi 66932916 308 LAHPYL 313
Cdd:cd14224 375 LRHPWL 380
PKc_MAPKK_plant_like cd06623
Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and ...
31-318 3.71e-33

Catalytic domain of Plant dual-specificity Mitogen-Activated Protein Kinase Kinases and similar proteins; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include MAPKKs from plants, kinetoplastids, alveolates, and mycetozoa. The MAPKK, LmxPK4, from Leishmania mexicana, is important in differentiation and virulence. Dictyostelium discoideum MEK1 is required for proper chemotaxis; MEK1 null mutants display severe defects in cell polarization and directional movement. Plants contain multiple MAPKKs like other eukaryotes. The Arabidopsis genome encodes for 10 MAPKKs while poplar and rice contain 13 MAPKKs each. The functions of these proteins have not been fully elucidated. There is evidence to suggest that MAPK cascades are involved in plant stress responses. In Arabidopsis, MKK3 plays a role in pathogen signaling; MKK2 is involved in cold and salt stress signaling; MKK4/MKK5 participates in innate immunity; and MKK7 regulates basal and systemic acquired resistance. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132954 [Multi-domain]  Cd Length: 264  Bit Score: 123.86  E-value: 3.71e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENII---GIndiiraptIEQMKDVYIVQDL 107
Cdd:cd06623   9 LGQGSSGVVYKVRHKPTGKIYALKKIHVDGDEEFRKQLLRELKTLRSCESPYVVkcyGA--------FYKEGEISIVLEY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 ME----TDLYKllKTQHLSNDHICYFLYQILRGLKYIHS-ANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPdhdhTG 182
Cdd:cd06623  81 MDggslADLLK--KVGKIPEPVLAYIARQILKGLDYLHTkRHIIHRDIKPSNLLINSKGEVKIADFGISKVLEN----TL 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 183 FLT-EYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRpiFPgkhYLDQlnhilgilGSPSQEDLNCIINLKAr 261
Cdd:cd06623 155 DQCnTFVGTVTYMSPE-RIQGESYSYAADIWSLGLTLLECALGK--FP---FLPP--------GQPSFFELMQAICDGP- 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 262 nyLLSLPHKNKVPwnrlfpnadsKALDLLDKMLTFNPHKRIEVEQALAHPYLeQYYD 318
Cdd:cd06623 220 --PPSLPAEEFSP----------EFRDFISACLQKDPKKRPSAAELLQHPFI-KKAD 263
STKc_RSK1_C cd14175
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called ...
25-315 7.60e-33

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 1 (also called Ribosomal protein S6 kinase alpha-1 or 90kDa ribosomal protein S6 kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK1 is also called S6K-alpha-1, RPS6KA1, p90RSK1 or MAPK-activated protein kinase 1a (MAPKAPK-1a). It is a component of the insulin transduction pathway, regulating the function of IRS1. It also interacts with PKA and promotes its inactivation. RSK1 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271077 [Multi-domain]  Cd Length: 291  Bit Score: 123.98  E-value: 7.60e-33
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYcqrtlREIKILLRF-RHENIIGINDIIraptiEQMKDVYI 103
Cdd:cd14175   3 YVVKETIGVGSYSVCKRCVHKATNMEYAVKVIDKSKRDPS-----EEIEILLRYgQHPNIITLKDVY-----DDGKHVYL 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL-----NTTCdLKICDFGLARVADP 176
Cdd:cd14175  73 VTELMRGGelLDKILRQKFFSEREASSVLHTICKTVEYLHSQGVVHRDLKPSNILYvdesgNPES-LRICDFGFAKQLRA 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 DHdhtGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIF---PGkhylDQLNHILGILGSPSqedln 253
Cdd:cd14175 152 EN---GLLMTPCYTANFVAPEV-LKRQGYDEGCDIWSLGILLYTMLAGYTPFangPS----DTPEEILTRIGSGK----- 218
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916 254 ciINLKARNyllslphknkvpWNRLfpnaDSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
Cdd:cd14175 219 --FTLSGGN------------WNTV----SDAAKDLVSKMLHVDPHQRLTAKQVLQHPWITQ 262
STKc_RCK1-like cd14096
Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the ...
24-313 3.63e-32

Catalytic domain of RCK1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal STKs including Saccharomyces cerevisiae RCK1 and RCK2, Schizosaccharomyces pombe Sty1-regulated kinase 1 (Srk1), and similar proteins. RCK1, RCK2 (or Rck2p), and Srk1 are MAPK-activated protein kinases. RCK1 and RCK2 are involved in oxidative and metal stress resistance in budding yeast. RCK2 also regulates rapamycin sensitivity in both S. cerevisiae and Candida albicans. Srk1 is activated by Sty1/Spc1 and is involved in negatively regulating cell cycle progression by inhibiting Cdc25. The RCK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270998 [Multi-domain]  Cd Length: 295  Bit Score: 122.16  E-value: 3.63e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVR-VAIKKISPFE-HQTYCQRT-----LREIKILLRFRHENIIGINDIIRAPtie 96
Cdd:cd14096   2 NYRLINKIGEGAFSNVYKAVPLRNTGKpVAIKVVRKADlSSDNLKGSsraniLKEVQIMKRLSHPNIVKLLDFQESD--- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 qmKDVYIVQDLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL----------------- 157
Cdd:cd14096  79 --EYYYIVLELADGGeiFHQIVRLTYFSEDLSRHVITQVASAVKYLHEIGVVHRDIKPENLLFepipfipsivklrkadd 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 158 -NTTCD---------------LKICDFGLARVADPDHDHTGflteyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEM 221
Cdd:cd14096 157 dETKVDegefipgvggggigiVKLADFGLSKQVWDSNTKTP-----CGTVGYTAPEV-VKDERYSKKVDMWALGCVLYTL 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 222 LSNRPIFpgkhYldqlnhilgilgspsQEDLNCIINLKARNYLLSLPhknkvPWnrlFPNADSKALDLLDKMLTFNPHKR 301
Cdd:cd14096 231 LCGFPPF----Y---------------DESIETLTEKISRGDYTFLS-----PW---WDEISKSAKDLISHLLTVDPAKR 283
                       330
                ....*....|..
gi 66932916 302 IEVEQALAHPYL 313
Cdd:cd14096 284 YDIDEFLAHPWI 295
STKc_PhKG cd14093
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs ...
68-313 6.32e-32

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). Each subunit has tissue-specific isoforms or splice variants. Vertebrates contain two isoforms of the gamma subunit (gamma 1 and gamma 2). The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270995 [Multi-domain]  Cd Length: 272  Bit Score: 120.92  E-value: 6.32e-32
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  68 TLREIKILLRF-RHENIIGINDIIRAPTIeqmkdVYIVQDLMET-DLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSAN 144
Cdd:cd14093  55 TRREIEILRQVsGHPNIIELHDVFESPTF-----IFLVFELCRKgELFDYLtEVVTLSEKKTRRIMRQLFEAVEFLHSLN 129
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 145 VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHdhtgFLTEYVATRWYRAPEIM-----LNSKGYTKSIDIWSVGCILA 219
Cdd:cd14093 130 IVHRDLKPENILLDDNLNVKISDFGFATRLDEGE----KLRELCGTPGYLAPEVLkcsmyDNAPGYGKEVDMWACGVIMY 205
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 220 EMLSNRPIFPGKHYLDQLNHILG---ILGSPSQEDLnciinlkarnyllslphknkvpwnrlfpNADSKalDLLDKMLTF 296
Cdd:cd14093 206 TLLAGCPPFWHRKQMVMLRNIMEgkyEFGSPEWDDI----------------------------SDTAK--DLISKLLVV 255
                       250
                ....*....|....*..
gi 66932916 297 NPHKRIEVEQALAHPYL 313
Cdd:cd14093 256 DPKKRLTAEEALEHPFF 272
STKc_Rad53_Cds1 cd14098
Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the ...
24-312 1.08e-31

Catalytic domain of the yeast Serine/Threonine Kinases, Rad53 and Cds1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Rad53 and Cds1 are the checkpoint kinase 2 (Chk2) homologs found in budding and fission yeast, respectively. They play a central role in the cell's response to DNA lesions to prevent genome rearrangements and maintain genome integrity. They are phosphorylated in response to DNA damage and incomplete replication, and are essential for checkpoint control. They help promote DNA repair by stalling the cell cycle prior to mitosis in the presence of DNA damage. The Rad53/Cds1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271000 [Multi-domain]  Cd Length: 265  Bit Score: 120.27  E-value: 1.08e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYD-NVNKVRvAIKKISpfEHQ-TYCQRTL----REIKILLRFRHENIIGINDIIraptiEQ 97
Cdd:cd14098   1 KYQIIDRLGSGTFAEVKKAVEvETGKMR-AIKQIV--KRKvAGNDKNLqlfqREINILKSLEHPGIVRLIDWY-----ED 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  98 MKDVYIVQDLMET-DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD--LKICDFGLARV 173
Cdd:cd14098  73 DQHIYLVMEYVEGgDLMDFIMAWgAIPEQHARELTKQILEAMAYTHSMGITHRDLKPENILITQDDPviVKISDFGLAKV 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 AdpdhdHTG-FLTEYVATRWYRAPEIMLNSK-----GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGilGSP 247
Cdd:cd14098 153 I-----HTGtFLVTFCGTMAYLAPEILMSKEqnlqgGYSNLVDMWSVGCLVYVMLTGALPFDGSSQLPVEKRIRK--GRY 225
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 248 SQEDLNCIinlkarnyllslphknkvpwnrlfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14098 226 TQPPLVDF-------------------------NISEEAIDFILRLLDVDPEKRMTAAQALDHPW 265
PKc_Mps1 cd14131
Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle ...
24-313 2.46e-31

Catalytic domain of the Dual-specificity Mitotic checkpoint protein kinase, Monopolar spindle 1 (also called TTK); Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TTK/Mps1 is a spindle checkpoint kinase that was first discovered due to its necessity in centrosome duplication in budding yeast. It was later found to function in the spindle assembly checkpoint, which monitors the proper attachment of chromosomes to the mitotic spindle. In yeast, substrates of Mps1 include the spindle pole body components Spc98p, Spc110p, and Spc42p. The TTK/Mps1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271033 [Multi-domain]  Cd Length: 271  Bit Score: 119.24  E-value: 2.46e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVrVAIKKI--SPFEHQTYcQRTLREIKILLRFRHE-NIIGINDiirAPTIEQMKD 100
Cdd:cd14131   2 PYEILKQLGKGGSSKVYKVLNPKKKI-YALKRVdlEGADEQTL-QSYKNEIELLKKLKGSdRIIQLYD---YEVTDEDDY 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLMETDLYKLLKTQHLSN---DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLnTTCDLKICDFGLARVADPd 177
Cdd:cd14131  77 LYMVMECGEIDLATILKKKRPKPidpNFIRYYWKQMLEAVHTIHEEGIVHSDLKPANFLL-VKGRLKLIDFGIAKAIQN- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 hDHTGFLTE-YVATRWYRAPEIMLNSKGYT---------KSIDIWSVGCILAEMLSNRPIFPgkHYLDQLNHILGILGsp 247
Cdd:cd14131 155 -DTTSIVRDsQVGTLNYMSPEAIKDTSASGegkpkskigRPSDVWSLGCILYQMVYGKTPFQ--HITNPIAKLQAIID-- 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 248 sqedlnciinlkarnyllslPHkNKVPWNRlFPNADskALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14131 230 --------------------PN-HEIEFPD-IPNPD--LIDVMKRCLQRDPKKRPSIPELLNHPFL 271
STKc_Nek2 cd08217
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
25-313 3.38e-31

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Nek2 subfamily includes Aspergillus nidulans NIMA kinase, the founding member of the Nek family, which was identified in a screen for cell cycle mutants prevented from entering mitosis. NIMA is essential for mitotic entry and progression through mitosis, and its degradation is essential for mitotic exit. NIMA is involved in nuclear membrane fission. Vertebrate Nek2 is a cell cycle-regulated STK, localized in centrosomes and kinetochores, that regulates centrosome splitting at the G2/M phase. It also interacts with other mitotic kinases such as Polo-like kinase 1 and may play a role in spindle checkpoint. An increase in the expression of the human NEK2 gene is strongly associated with the progression of non-Hodgkin lymphoma. Nek2 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. It The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270857 [Multi-domain]  Cd Length: 265  Bit Score: 118.80  E-value: 3.38e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCsaydnvnKVR-------VAIKKISpFEH--QTYCQRTLREIKILLRFRHENIIG-INDIIrapt 94
Cdd:cd08217   2 YEVLETIGKGSFGTVR-------KVRrksdgkiLVWKEID-YGKmsEKEKQQLVSEVNILRELKHPNIVRyYDRIV---- 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  95 IEQMKDVYIVqdlME----TDLYKLLK-----TQHLSNDHICYFLYQILRGLKYIHSAN-----VLHRDLKPSNLLLNTT 160
Cdd:cd08217  70 DRANTTLYIV---MEycegGDLAQLIKkckkeNQYIPEEFIWKIFTQLLLALYECHNRSvgggkILHRDLKPANIFLDSD 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 161 CDLKICDFGLARVAdpdHDHTGFLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFpgkhyldqlnhi 240
Cdd:cd08217 147 NNVKLGDFGLARVL---SHDSSFAKTYVGTPYYMSPELLNEQS-YDEKSDIWSLGCLIYELCALHPPF------------ 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 241 lgilgspsqedlnciinlKARNYlLSLPHKNKV-PWNRLfPNADSKALD-LLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd08217 211 ------------------QAANQ-LELAKKIKEgKFPRI-PSRYSSELNeVIKSMLNVDPDKRPSVEELLQLPLI 265
PK_Tyr_Ser-Thr pfam07714
Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role ...
31-224 4.54e-31

Protein tyrosine and serine/threonine kinase; Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyze the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyze the reverse process. Protein kinases fall into three broad classes, characterized with respect to substrate specificity; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.


Pssm-ID: 462242 [Multi-domain]  Cd Length: 258  Bit Score: 118.37  E-value: 4.54e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916    31 IGEGAYGMVCSAY----DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENI---IGIndiiraptIEQMKDVYI 103
Cdd:pfam07714   7 LGEGAFGEVYKGTlkgeGENTKIKVAVKTLKEGADEEEREDFLEEASIMKKLDHPNIvklLGV--------CTQGEPLYI 78
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   104 VQDLMET-DLYKLL--KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
Cdd:pfam07714  79 VTEYMPGgDLLDFLrkHKRKLTLKDLLSMALQIAKGMEYLESKNFVHRDLAARNCLVSENLVVKISDFGLSRDIYDDDYY 158
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 66932916   181 TGFLTEYVATRWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLSN 224
Cdd:pfam07714 159 RKRGGGKLPIKWM-APESLKDGKFTSKS-DVWSFGVLLWEIFTL 200
STKc_AMPK_alpha cd14079
Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein ...
31-313 5.09e-31

Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. AMPK, also called SNF1 (sucrose non-fermenting1) in yeasts and SnRK1 (SNF1-related kinase1) in plants, is a heterotrimeric enzyme composed of a catalytic alpha subunit and two regulatory subunits, beta and gamma. It is a stress-activated kinase that serves as master regulator of glucose and lipid metabolism by monitoring carbon and energy supplies, via sensing the cell's AMP:ATP ratio. In response to decreased ATP levels, it enhances energy-producing processes and inhibits energy-consuming pathways. Once activated, AMPK phosphorylates a broad range of downstream targets, with effects in carbohydrate metabolism and uptake, lipid and fatty acid biosynthesis, carbon energy storage, and inflammation, among others. Defects in energy homeostasis underlie many human diseases including Type 2 diabetes, obesity, heart disease, and cancer. As a result, AMPK has emerged as a therapeutic target in the treatment of these diseases. The AMPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270981 [Multi-domain]  Cd Length: 256  Bit Score: 118.14  E-value: 5.09e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIS--PFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTieqmkDVYIVqdlM 108
Cdd:cd14079  10 LGVGSFGKVKLAEHELTGHKVAVKILNrqKIKSLDMEEKIRREIQILKLFRHPHIIRLYEVIETPT-----DIFMV---M 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 E----TDLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHdhtgF 183
Cdd:cd14079  82 EyvsgGELFDYIVQKGrLSEDEARRFFQQIISGVEYCHRHMVVHRDLKPENLLLDSNMNVKIADFGLSNIMRDGE----F 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYRAPEImLNSKGYTKS-IDIWSVGCILAEMLSNRPIFPGKHyldqlnhilgilgspsqedlncIINL--KA 260
Cdd:cd14079 158 LKTSCGSPNYAAPEV-ISGKLYAGPeVDVWSCGVILYALLCGSLPFDDEH----------------------IPNLfkKI 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 261 RNYLLSLPHknkvpwnrlfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14079 215 KSGIYTIPS-----------HLSPGARDLIKRMLVVDPLKRITIPEIRQHPWF 256
STKc_CNK2-like cd08530
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar ...
24-311 6.44e-31

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii CNK2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii CNK2 has both cilliary and cell cycle functions. It influences flagellar length through promoting flagellar disassembly, and it regulates cell size, through influencing the size threshold at which cells commit to mitosis. This subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily includes CNK1, and -2. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270869 [Multi-domain]  Cd Length: 256  Bit Score: 117.88  E-value: 6.44e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGINdiiraptiEQMKDVY 102
Cdd:cd08530   1 DFKVLKKLGKGSYGSVYKVKRLSDNQVYALKEVNlGSLSQKEREDSVNEIRLLASVNHPNIIRYK--------EAFLDGN 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLME----TDLYKLLKTQH-----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV 173
Cdd:cd08530  73 RLCIVMEyapfGDLSKLISKRKkkrrlFPEDDIWRIFIQMLRGLKALHDQKILHRDLKSANILLSAGDLVKIGDLGISKV 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 AdpdhdHTGFLTEYVATRWYRAPEIMlNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhyldqlnhilgilgspSQEDLN 253
Cdd:cd08530 153 L-----KKNLAKTQIGTPLYAAPEVW-KGRPYDYKSDIWSLGCLLYEMATFRPPFEAR----------------TMQELR 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 254 CIInlkARNYLLSLPHKNkvpwnrlfpNADskALDLLDKMLTFNPHKRIEVEQALAHP 311
Cdd:cd08530 211 YKV---CRGKFPPIPPVY---------SQD--LQQIIRSLLQVNPKKRPSCDKLLQSP 254
STKc_BRSK1_2 cd14081
Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the ...
31-313 8.97e-31

Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BRSK1, also called SAD-B or SAD1 (Synapses of Amphids Defective homolog 1), and BRSK2, also called SAD-A, are highly expressed in mammalian forebrain. They play important roles in establishing neuronal polarity. BRSK1/2 double knock-out mice die soon after birth, showing thin cerebral cortices due to disordered subplate layers and neurons that lack distinct axons and dendrites. BRSK1 regulates presynaptic neurotransmitter release. Its activity fluctuates during cell cysle progression and it acts as a regulator of centrosome duplication. BRSK2 is also abundant in pancreatic islets, where it is involved in the regulation of glucose-stimulated insulin secretion. The BRSK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270983 [Multi-domain]  Cd Length: 255  Bit Score: 117.35  E-value: 8.97e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKI--SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLM 108
Cdd:cd14081   9 LGKGQTGLVKLAKHCVTGQKVAIKIVnkEKLSKESVLMKVEREIAIMKLIEHPNVLKLYDVY-----ENKKYLYLVLEYV 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYK-LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHdhtgFLTE 186
Cdd:cd14081  84 SGgELFDyLVKKGRLTEKEARKFFRQIISALDYCHSHSICHRDLKPENLLLDEKNNIKIADFGMASLQPEGS----LLET 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 187 YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGkhyldqlnhilgilgspsqEDLNCIINlKARNYLLS 266
Cdd:cd14081 160 SCGSPHYACPEVIKGEKYDGRKADIWSCGVILYALLVGALPFDD-------------------DNLRQLLE-KVKRGVFH 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 267 LPHknkvpwnrlFPNADSKalDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14081 220 IPH---------FISPDAQ--DLLRRMLEVNPEKRITIEEIKKHPWF 255
STKc_CaMKII cd14086
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
31-315 9.94e-31

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. In addition, CaMKII contains a C-terminal association domain that facilitates oligomerization. There are four CaMKII proteins (alpha, beta, gamma, delta) encoded by different genes; each gene undergoes alternative splicing to produce more than 30 isoforms. CaMKII-alpha and -beta are enriched in neurons while CaMKII-gamma and -delta are predominant in myocardium. CaMKII is a signaling molecule that translates upstream calcium and reactive oxygen species (ROS) signals into downstream responses that play important roles in synaptic function and cardiovascular physiology. It is a major component of the postsynaptic density and is critical in regulating synaptic plasticity including long-term potentiation. It is critical in regulating ion channels and proteins involved in myocardial excitation-contraction and excitation-transcription coupling. Excessive CaMKII activity promotes processes that contribute to heart failure and arrhythmias. The CaMKII subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270988 [Multi-domain]  Cd Length: 292  Bit Score: 118.29  E-value: 9.94e-31
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIK-----KISPFEHQtycqRTLREIKILLRFRHENIIGINDIIRAPTIEqmkdvYIVQ 105
Cdd:cd14086   9 LGKGAFSVVRRCVQKSTGQEFAAKiintkKLSARDHQ----KLEREARICRLLKHPNIVRLHDSISEEGFH-----YLVF 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMET-DLYK-LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTC---DLKICDFGLARVADPDHDH 180
Cdd:cd14086  80 DLVTGgELFEdIVAREFYSEADASHCIQQILESVNHCHQNGIVHRDLKPENLLLASKSkgaAVKLADFGLAIEVQGDQQA 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 -TGFlteyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhyLDQLNHILgilgspsqedlncIINLK 259
Cdd:cd14086 160 wFGF----AGTPGYLSPEV-LRKDPYGKPVDIWACGVILYILLVGYPPF-----WDEDQHRL-------------YAQIK 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 260 ARNYLLSLPHknkvpWNRLFPNADskalDLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
Cdd:cd14086 217 AGAYDYPSPE-----WDTVTPEAK----DLINQMLTVNPAKRITAAEALKHPWICQ 263
STKc_HIPK3 cd14229
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3; ...
25-313 1.86e-30

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPK3 is a Fas-interacting protein that induces FADD (Fas-associated death domain) phosphorylation and mediates FasL-induced JNK activation. Overexpression of HIPK3 does not affect cell death, however its expression in prostate cancer cells contributes to increased resistance to Fas receptor-mediated apoptosis. HIPK3 also plays a role in regulating steroidogenic gene expression. In response to cAMP, HIPK3 activates the phosphorylation of JNK and c-Jun, leading to increased activity of the transcription factor SF-1 (Steroidogenic factor 1), a key regulator for steroid biosynthesis in the gonad and adrenal gland. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). The HIPK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271131 [Multi-domain]  Cd Length: 330  Bit Score: 118.59  E-value: 1.86e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINdIIRAPTIEQMKD-VYI 103
Cdd:cd14229   2 YEVLDFLGRGTFGQVVKCWKRGTNEIVAVKILK--NHPSYARQGQIEVGILARLSNENADEFN-FVRAYECFQHRNhTCL 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLKTQHLSN---DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL----NTTCDLKICDFGLArvadp 176
Cdd:cd14229  79 VFEMLEQNLYDFLKQNKFSPlplKVIRPILQQVATALKKLKSLGLIHADLKPENIMLvdpvRQPYRVKVIDFGSA----- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 DHDHTGFLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN--- 253
Cdd:cd14229 154 SHVSKTVCSTYLQSRYYRAPEIILGLP-FCEAIDMWSLGCVIAELFLGWPLYPGALEYDQIRYISQTQGLPGEQLLNvgt 232
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 254 ------C-----------------------IINLKARNYLLS----LPHKNKV----PWNRLFPNADSKA-LDLLDKMLT 295
Cdd:cd14229 233 ktsrffCretdapysswrlktleeheaetgMKSKEARKYIFNslddIAHVNMVmdleGSDLLAEKADRREfVALLKKMLL 312
                       330
                ....*....|....*...
gi 66932916 296 FNPHKRIEVEQALAHPYL 313
Cdd:cd14229 313 IDADLRITPADTLSHPFV 330
STKc_PKD cd14082
Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer ...
31-312 2.67e-30

Catalytic domain of the Serine/Threonine kinase, Protein Kinase D; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKDs are important regulators of many intracellular signaling pathways such as ERK and JNK, and cellular processes including the organization of the trans-Golgi network, membrane trafficking, cell proliferation, migration, and apoptosis. They contain N-terminal cysteine-rich zinc binding C1 (PKC conserved region 1), central PH (Pleckstrin Homology), and C-terminal catalytic kinase domains. Mammals harbor three types of PKDs: PKD1 (or PKCmu), PKD2, and PKD3 (or PKCnu). PKDs are activated in a PKC-dependent manner by many agents including diacylglycerol (DAG), PDGF, neuropeptides, oxidative stress, and tumor-promoting phorbol esters, among others. The PKD subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270984 [Multi-domain]  Cd Length: 260  Bit Score: 116.36  E-value: 2.67e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLR-EIKILLRFRHENIIGINDIIRAPtieqmKDVYIVQDLME 109
Cdd:cd14082  11 LGSGQFGIVYGGKHRKTGRDVAIKVIDKLRFPTKQESQLRnEVAILQQLSHPGVVNLECMFETP-----ERVFVVMEKLH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKTQHLS--NDHICYFLY-QILRGLKYIHSANVLHRDLKPSNLLLNTTCDL---KICDFGLARVAdpdhDHTGF 183
Cdd:cd14082  86 GDMLEMILSSEKGrlPERITKFLVtQILVALRYLHSKNIVHCDLKPENVLLASAEPFpqvKLCDFGFARII----GEKSF 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYRAPEIMLNsKGYTKSIDIWSVGCILAEMLSNrpIFPgkhyldqLNHilgilgspsQEDLNCIINLKARNY 263
Cdd:cd14082 162 RRSVVGTPAYLAPEVLRN-KGYNRSLDMWSVGVIIYVSLSG--TFP-------FNE---------DEDINDQIQNAAFMY 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 264 LLSlphknkvPWNRLFPNadskALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14082 223 PPN-------PWKEISPD----AIDLINNLLQVKMRKRYSVDKSLSHPW 260
STKc_Yank1 cd05578
Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the ...
31-313 2.81e-30

Catalytic domain of the Serine/Threonine Kinase, Yank1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily contains uncharacterized STKs with similarity to the human protein designated as Yank1 or STK32A. The Yank1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270730 [Multi-domain]  Cd Length: 257  Bit Score: 116.20  E-value: 2.81e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEH--QTYCQRTLREIKILLRFRHENIIGINDiirapTIEQMKDVYIVQDLM 108
Cdd:cd05578   8 IGKGSFGKVCIVQKKDTKKMFAMKYMNKQKCieKDSVRNVLNELEILQELEHPFLVNLWY-----SFQDEEDMYMVVDLL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DL-YKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHdhtgFLTE 186
Cdd:cd05578  83 LGgDLrYHLQQKVKFSEETVKFYICEIVLALDYLHSKNIIHRDIKPDNILLDEQGHVHITDFNIATKLTDGT----LATS 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 187 YVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhyldqlnhilgilgspsqedlnciiNLKARNYLLS 266
Cdd:cd05578 159 TSGTKPYMAPEV-FMRAGYSFAVDWWSLGVTAYEMLRGKRPYEIH-------------------------SRTSIEEIRA 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 267 LPHKNKVpwnrLFPNADSK-ALDLLDKMLTFNPHKRI-EVEQALAHPYL 313
Cdd:cd05578 213 KFETASV----LYPAGWSEeAIDLINKLLERDPQKRLgDLSDLKNHPYF 257
STKc_HIPK cd14211
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase; STKs ...
25-313 3.09e-30

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). They show speckled localization in the nucleus, apart from the nucleoles. They play roles in the regulation of many nuclear pathways including gene transcription, cell survival, proliferation, differentiation, development, and DNA damage response. Vertebrates contain three HIPKs (HIPK1-3) and mammals harbor an additional family member HIPK4, which does not contain a homeobox-interacting domain and is localized in the cytoplasm. HIPK2, the most studied HIPK, is a coregulator of many transcription factors and cofactors and it regulates gene transcription during development and in DNA damage response. The HIPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271113 [Multi-domain]  Cd Length: 329  Bit Score: 117.93  E-value: 3.09e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINdIIRAPTIEQMKD-VYI 103
Cdd:cd14211   1 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILK--NHPSYARQGQIEVSILSRLSQENADEFN-FVRAYECFQHKNhTCL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL--NTTCD--LKICDFGLArvadp 176
Cdd:cd14211  78 VFEMLEQNLYDFLKQnkfSPLPLKYIRPILQQVLTALLKLKSLGLIHADLKPENIMLvdPVRQPyrVKVIDFGSA----- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 DHDHTGFLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC-- 254
Cdd:cd14211 153 SHVSKAVCSTYLQSRYYRAPEIILGLP-FCEAIDMWSLGCVIAELFLGWPLYPGSSEYDQIRYISQTQGLPAEHLLNAat 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 255 ------------------------------IINLKARNYLL-SLPHKNKVPWNRLFPNADSKA--------LDLLDKMLT 295
Cdd:cd14211 232 ktsrffnrdpdspyplwrlktpeeheaetgIKSKEARKYIFnCLDDMAQVNGPSDLEGSELLAekadrrefIDLLKRMLT 311
                       330
                ....*....|....*...
gi 66932916 296 FNPHKRIEVEQALAHPYL 313
Cdd:cd14211 312 IDQERRITPGEALNHPFV 329
STKc_ULK3 cd14121
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the ...
31-312 4.90e-30

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK3 mRNA is up-regulated in fibroblasts after Ras-induced senescence, and its overexpression induces both autophagy and senescence in a fibroblast cell line. ULK3, through its kinase activity, positively regulates Gli proteins, mediators of the Sonic hedgehog (Shh) signaling pathway that is implicated in tissue homeostasis maintenance and neurogenesis. It is inhibited by binding to Suppressor of Fused (Sufu). The ULK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271023 [Multi-domain]  Cd Length: 252  Bit Score: 115.46  E-value: 4.90e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVR-VAIKKISPFE-HQTYCQRTLREIKILLRFRHENIIgindiiraptieQMKD-------V 101
Cdd:cd14121   3 LGSGTYATVYKAYRKSGAREvVAVKCVSKSSlNKASTENLLTEIELLKKLKHPHIV------------ELKDfqwdeehI 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVqdlME----TDLYKLLKTQHLSNDHIC-YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD--LKICDFGLA-RV 173
Cdd:cd14121  71 YLI---MEycsgGDLSRFIRSRRTLPESTVrRFLQQLASALQFLREHNISHMDLKPQNLLLSSRYNpvLKLADFGFAqHL 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 ADPDHDHTgflteYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFpgkhyldqlnhilgilGSPSQEDLN 253
Cdd:cd14121 148 KPNDEAHS-----LRGSPLYMAPEMILKKK-YDARVDLWSVGVILYECLFGRAPF----------------ASRSFEELE 205
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 254 CIINlkaRNYLLSLPhknkvpwnrLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14121 206 EKIR---SSKPIEIP---------TRPELSADCRDLLLRLLQRDPDRRISFEEFFAHPF 252
STKc_LKB1 cd14119
Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer ...
31-313 6.13e-30

Catalytic domain of the Serine/Threonine kinase, Liver Kinase B1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LKB1, also called STK11, was first identified as a tumor suppressor responsible for Peutz-Jeghers syndrome, a disorder that leads to an increased risk of spontaneous epithelial cancer. It serves as a master upstream kinase that activates AMP-activated protein kinase (AMPK) and most AMPK-like kinases. LKB1 and AMPK are part of an energy-sensing pathway that links cell energy to metabolism and cell growth. They play critical roles in the establishment and maintenance of cell polarity, cell proliferation, cytoskeletal organization, as well as T-cell metabolism, including T-cell development, homeostasis, and effector function. To be activated, LKB1 requires the adaptor proteins STe20-Related ADaptor (STRAD) and mouse protein 25 (MO25). The LKB1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271021 [Multi-domain]  Cd Length: 255  Bit Score: 115.05  E-value: 6.13e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIK--------KISPFEhqtycQRTLREIKILLRFRHENIIGINDIIRAPtiEQMKdVY 102
Cdd:cd14119   1 LGEGSYGKVKEVLDTETLCRRAVKilkkrklrRIPNGE-----ANVKREIQILRRLNHRNVIKLVDVLYNE--EKQK-LY 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IV---------QDLMETDLYKLLKTQ-HlsndhiCYFLyQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR 172
Cdd:cd14119  73 MVmeycvgglqEMLDSAPDKRLPIWQaH------GYFV-QLIDGLEYLHSQGIIHKDIKPGNLLLTTDGTLKISDFGVAE 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 VADPdHDHTGFLTEYVATRWYRAPEIMlNSKGYTK--SIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqe 250
Cdd:cd14119 146 ALDL-FAEDDTCTTSQGSPAFQPPEIA-NGQDSFSgfKVDIWSAGVTLYNMTTGKYPFEGDNIYKLFENI---------- 213
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 251 dlnciinlkARNYlLSLPhknkvpwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14119 214 ---------GKGE-YTIP-----------DDVDPDLQDLLRGMLEKDPEKRFTIEQIRQHPWF 255
STKc_EIF2AK cd13996
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
27-222 6.17e-30

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: General Control Non-derepressible-2 (GCN2) which is activated during amino acid or serum starvation; protein kinase regulated by RNA (PKR) which is activated by double stranded RNA; heme-regulated inhibitor kinase (HRI) which is activated under heme-deficient conditions; and PKR-like endoplasmic reticulum kinase (PERK) which is activated when misfolded proteins accumulate in the ER. The EIF2AK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270898 [Multi-domain]  Cd Length: 273  Bit Score: 115.47  E-value: 6.17e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  27 NLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDiiraPTIEqMKDVYIVQD 106
Cdd:cd13996  10 EIELLGSGGFGSVYKVRNKVDGVTYAIKKIRLTEKSSASEKVLREVKALAKLNHPNIVRYYT----AWVE-EPPLYIQME 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LMET-DLYKLL--KTQHLSNDHICYF--LYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD-LKICDFGLARVADPDHDH 180
Cdd:cd13996  85 LCEGgTLRDWIdrRNSSSKNDRKLALelFKQILKGVSYIHSKGIVHRDLKPSNIFLDNDDLqVKIGDFGLATSIGNQKRE 164
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 181 TGFL-----------TEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEML 222
Cdd:cd13996 165 LNNLnnnnngntsnnSVGIGTPLYASPE-QLDGENYNEKADIYSLGIILFEML 216
STKc_MAST_like cd05579
Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs ...
31-314 6.43e-30

Catalytic domain of Microtubule-associated serine/threonine (MAST) kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAST kinases, MAST-like (MASTL) kinases (also called greatwall kinase or Gwl), and fungal kinases with similarity to Saccharomyces cerevisiae Rim15 and Schizosaccharomyces pombe cek1. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. MASTL kinases carry only a catalytic domain which contains a long insert relative to other kinases. The fungal kinases in this subfamily harbor other domains in addition to a central catalytic domain, which like in MASTL, also contains an insert relative to MAST kinases. Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MASTL/Gwl is involved in the regulation of mitotic entry, mRNA stabilization, and DNA checkpoint recovery. The fungal proteins Rim15 and cek1 are involved in the regulation of meiosis and mitosis, respectively. The MAST-like kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270731 [Multi-domain]  Cd Length: 272  Bit Score: 115.39  E-value: 6.43e-30
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISP----FEHQTycQRTLREIKILLRFRHENIIGINDIIRAPtieqmKDVYIVQD 106
Cdd:cd05579   1 ISRGAYGRVYLAKKKSTGDLYAIKVIKKrdmiRKNQV--DSVLAERNILSQAQNPFVVKLYYSFQGK-----KNLYLVME 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LMET-DLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----------- 173
Cdd:cd05579  74 YLPGgDLYSLLENvGALDEDVARIYIAEIVLALEYLHSHGIIHRDLKPDNILIDANGHLKLTDFGLSKVglvrrqiklsi 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 ------ADPDHDHTGFLTEYvatrwYRAPEIMLNsKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgsp 247
Cdd:cd05579 154 qkksngAPEKEDRRIVGTPD-----YLAPEILLG-QGHGKTVDWWSLGVILYEFLVGIPPFHAETPEEIFQNIL------ 221
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 248 sqedlnciinlkarnyllslphKNKVPWNRlFPNADSKALDLLDKMLTFNPHKRI---EVEQALAHPYLE 314
Cdd:cd05579 222 ----------------------NGKIEWPE-DPEVSDEAKDLISKLLTPDPEKRLgakGIEEIKNHPFFK 268
STKc_SnRK3 cd14663
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
24-312 1.05e-29

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK3 is represented in this cd. The SnRK3 group contains members also known as CBL-interacting protein kinase, salt overly sensitive 2, SOS3-interacting proteins and protein kinase S. These kinases interact with calcium-binding proteins such as SOS3, SCaBPs, and CBL proteins, and are involved in responses to salt stress and in sugar and ABA signaling. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271133 [Multi-domain]  Cd Length: 256  Bit Score: 114.42  E-value: 1.05e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI--SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTieqmkDV 101
Cdd:cd14663   1 RYELGRTLGEGTFAKVKFARNTKTGESVAIKIIdkEQVAREGMVEQIKREIAIMKLLRHPNIVELHEVMATKT-----KI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMET-DLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPdHD 179
Cdd:cd14663  76 FFVMELVTGgELFsKIAKNGRLKEDKARKYFQQLIDAVDYCHSRGVFHRDLKPENLLLDEDGNLKISDFGLSALSEQ-FR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 HTGFLTEYVATRWYRAPEImLNSKGYTKSI-DIWSVGCILAEMLSnrpifpgkhyldqlnhilgilGSPSQEDLNcIINL 258
Cdd:cd14663 155 QDGLLHTTCGTPNYVAPEV-LARRGYDGAKaDIWSCGVILFVLLA---------------------GYLPFDDEN-LMAL 211
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 259 KARNYllslphKNKVPWNRLFPnADSKAldLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14663 212 YRKIM------KGEFEYPRWFS-PGAKS--LIKRILDPNPSTRITVEQIMASPW 256
STKc_TSSK4-like cd14162
Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs ...
31-313 2.50e-29

Catalytic domain of testis-specific serine/threonine kinase 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK4, also called TSSK5, is expressed in testis from haploid round spermatids to mature spermatozoa. It phosphorylates Cre-Responsive Element Binding protein (CREB), facilitating the binding of CREB to the specific cis cAMP responsive element (CRE), which is important in activating genes related to germ cell differentiation. Mutations in the human TSSK4 gene is associated with infertile Chinese men with impaired spermatogenesis. The TSSK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271064 [Multi-domain]  Cd Length: 259  Bit Score: 113.55  E-value: 2.50e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEH-QTYCQRTL-REIKILLRFRHENIIGINDiirapTIEQMKDVYIVQDLM 108
Cdd:cd14162   8 LGHGSYAVVKKAYSTKHKCKVAIKIVSKKKApEDYLQKFLpREIEVIKGLKHPNLICFYE-----AIETTSRVYIIMELA 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHDHTGFLT 185
Cdd:cd14162  83 ENgDLLDYIRKNgALPEPQARRWFRQLVAGVEYCHSKGVVHRDLKCENLLLDKNNNLKITDFGFARgVMKTKDGKPKLSE 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 EYVATRWYRAPEImLNSKGYTKSI-DIWSVGCILAEMLSNRPIFpgkhylDQLNHilgilgspsqedlnciinlkaRNYL 264
Cdd:cd14162 163 TYCGSYAYASPEI-LRGIPYDPFLsDIWSMGVVLYTMVYGRLPF------DDSNL---------------------KVLL 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 265 LSLPHKNKVPWNrlfPNADSKALDLLDKMLTFNPhKRIEVEQALAHPYL 313
Cdd:cd14162 215 KQVQRRVVFPKN---PTVSEECKDLILRMLSPVK-KRITIEEIKRDPWF 259
STKc_Cdc7_like cd06627
Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs ...
31-313 3.93e-29

Catalytic domain of Cell division control protein 7-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include Schizosaccharomyces pombe Cdc7, Saccharomyces cerevisiae Cdc15, Arabidopsis thaliana mitogen-activated protein kinase kinase kinase (MAPKKK) epsilon, and related proteins. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Cdc7 is essential for cell division by playing a key role in the initiation of septum formation and cytokinesis. Budding yeast Cdc15 functions to coordinate mitotic exit with cytokinesis. Arabidopsis MAPKKK epsilon is required for pollen development in the plasma membrane. The Cdc7-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270797 [Multi-domain]  Cd Length: 254  Bit Score: 113.09  E-value: 3.93e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFE-HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIeqmkdVYIVQDLME 109
Cdd:cd06627   8 IGRGAFGSVYKGLNLNTGEFVAIKQISLEKiPKSDLKSVMGEIDLLKKLNHPNIVKYIGSVKTKDS-----LYIILEYVE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 T-DLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgflTEY 187
Cdd:cd06627  83 NgSLASIIKKfGKFPESLVAVYIYQVLEGLAYLHEQGVIHRDIKGANILTTKDGLVKLADFGVATKLNEVEKDE---NSV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 188 VATRWYRAPEIMLNSKGYTKSiDIWSVGCILAEMLSNRPIFpgkHYLDQLNHilgilgspsqedLNCIINlkarnyllsL 267
Cdd:cd06627 160 VGTPYWMAPEVIEMSGVTTAS-DIWSVGCTVIELLTGNPPY---YDLQPMAA------------LFRIVQ---------D 214
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 268 PHKnkvPwnrlFPNADSKAL-DLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06627 215 DHP---P----LPENISPELrDFLLQCFQKDPTLRPSAKELLKHPWL 254
STKc_MST1_2 cd06612
Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; ...
17-313 9.11e-29

Catalytic domain of the Serine/Threonine Kinases, Mammalian STe20-like protein kinase 1 and 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST1, MST2, and related proteins including Drosophila Hippo and Dictyostelium discoideum Krs1 (kinase responsive to stress 1). MST1/2 and Hippo are involved in a conserved pathway that governs cell contact inhibition, organ size control, and tumor development. MST1 activates the mitogen-activated protein kinases (MAPKs) p38 and c-Jun N-terminal kinase (JNK) through MKK7 and MEKK1 by acting as a MAPK kinase kinase kinase. Activation of JNK by MST1 leads to caspase activation and apoptosis. MST1 has also been implicated in cell proliferation and differentiation. Krs1 may regulate cell growth arrest and apoptosis in response to cellular stress. The MST1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132943 [Multi-domain]  Cd Length: 256  Bit Score: 111.97  E-value: 9.11e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  17 QVFDVgprytnLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQtycQRTLREIKILLRFRHENII---Gindiirap 93
Cdd:cd06612   3 EVFDI------LEKLGEGSYGSVYKAIHKETGQVVAIKVVPVEEDL---QEIIKEISILKQCDSPYIVkyyG-------- 65
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  94 TIEQMKDVYIVqdlME-------TDLYKLL-KTqhLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKI 165
Cdd:cd06612  66 SYFKNTDLWIV---MEycgagsvSDIMKITnKT--LTEEEIAAILYQTLKGLEYLHSNKKIHRDIKAGNILLNEEGQAKL 140
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 166 CDFGLARVAdpdhDHTGFLTE-YVATRWYRAPEIMLNSkGYTKSIDIWSVGCILAEMLSNRPIFPGKHyldQLNHILGIL 244
Cdd:cd06612 141 ADFGVSGQL----TDTMAKRNtVIGTPFWMAPEVIQEI-GYNNKADIWSLGITAIEMAEGKPPYSDIH---PMRAIFMIP 212
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 245 GSPSQEdlnciinlkarnylLSLPHKnkvpWNRLFPnadskalDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06612 213 NKPPPT--------------LSDPEK----WSPEFN-------DFVKKCLVKDPEERPSAIQLLQHPFI 256
STKc_PhKG1 cd14182
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs ...
55-316 1.35e-28

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 1 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 1 subunit (PhKG1) is also referred to as the muscle gamma isoform. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271084 [Multi-domain]  Cd Length: 276  Bit Score: 112.32  E-value: 1.35e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  55 KISPFEHQTYCQRTLREIKILLRFR-HENIIGINDiirapTIEQMKDVYIVQDLMET-DLYKLLKTQ-HLSNDHICYFLY 131
Cdd:cd14182  43 SFSPEEVQELREATLKEIDILRKVSgHPNIIQLKD-----TYETNTFFFLVFDLMKKgELFDYLTEKvTLSEKETRKIMR 117
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDhtgfLTEYVATRWYRAPEIML-----NSKGYT 206
Cdd:cd14182 118 ALLEVICALHKLNIVHRDLKPENILLDDDMNIKLTDFGFSCQLDPGEK----LREVCGTPGYLAPEIIEcsmddNHPGYG 193
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 207 KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsqedlnciinlkARNYLLSLPHknkvpWNrlfpNADSKA 286
Cdd:cd14182 194 KEVDMWSTGVIMYTLLAGSPPFWHRKQMLMLRMIM------------------SGNYQFGSPE-----WD----DRSDTV 246
                       250       260       270
                ....*....|....*....|....*....|
gi 66932916 287 LDLLDKMLTFNPHKRIEVEQALAHPYLEQY 316
Cdd:cd14182 247 KDLISRFLVVQPQKRYTAEEALAHPFFQQY 276
STKc_MEKK3_like cd06625
Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) ...
31-226 1.56e-28

Catalytic domain of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MEKK3, MEKK2, and related proteins; all contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKK) that activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270795 [Multi-domain]  Cd Length: 260  Bit Score: 111.68  E-value: 1.56e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIsPFEHQTycQRTLREIKI------LLR-FRHENIIGINDIIRAPtieqmKDVYI 103
Cdd:cd06625   8 LGQGAFGQVYLCYDADTGRELAVKQV-EIDPIN--TEASKEVKAleceiqLLKnLQHERIVQYYGCLQDE-----KSLSI 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYK--LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHT 181
Cdd:cd06625  80 FMEYMPGGSVKdeIKAYGALTENVTRKYTRQILEGLAYLHSNMIVHRDIKGANILRDSNGNVKLGDFGASKRLQTICSST 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 66932916 182 GFLTeYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRP 226
Cdd:cd06625 160 GMKS-VTGTPYWMSPEV-INGEGYGRKADIWSVGCTVVEMLTTKP 202
STKc_MLCK-like cd14006
Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs ...
31-312 1.61e-28

Catalytic kinase domain of Myosin Light Chain Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This family is composed of MLCKs and related MLCK-like kinase domains from giant STKs such as titin, obscurin, SPEG, Unc-89, Trio, kalirin, and Twitchin. Also included in this family are Death-Associated Protein Kinases (DAPKs) and Death-associated protein kinase-Related Apoptosis-inducing protein Kinase (DRAKs). MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. Titin, obscurin, Twitchin, and SPEG are muscle proteins involved in the contractile apparatus. The giant STKs are multidomain proteins containing immunoglobulin (Ig), fibronectin type III (FN3), SH3, RhoGEF, PH and kinase domains. Titin, obscurin, Twitchin, and SPEG contain many Ig domain repeats at the N-terminus, while Trio and Kalirin contain spectrin-like repeats. The MLCK-like family is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270908 [Multi-domain]  Cd Length: 247  Bit Score: 111.21  E-value: 1.61e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINDiirapTIEQMKDVYIVQDLMET 110
Cdd:cd14006   1 LGRGRFGVVKRCIEKATGREFAAKFIP--KRDKKKEAVLREISILNQLQHPRIIQLHE-----AYESPTELVLILELCSG 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 -DLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTC--DLKICDFGLARVADPdHDHTGFLT- 185
Cdd:cd14006  74 gELLDRLAERGsLSEEEVRTYMRQLLEGLQYLHNHHILHLDLKPENILLADRPspQIKIIDFGLARKLNP-GEELKEIFg 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 --EYVatrwyrAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhyldqlnhilgiLGSPSQEDLnciINLKARNY 263
Cdd:cd14006 153 tpEFV------APEI-VNGEPVSLATDMWSIGVLTYVLLSGLSPF---------------LGEDDQETL---ANISACRV 207
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 264 LLSLPHKNKVpwnrlfpnaDSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14006 208 DFSEEYFSSV---------SQEAKDFIRKLLVKEPRKRPTAQEALQHPW 247
STKc_ASK cd06624
Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs ...
31-313 1.81e-28

Catalytic domain of the Serine/Threonine Kinase, Apoptosis signal-regulating kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily are mitogen-activated protein kinase (MAPK) kinase kinases (MAPKKKs or MKKKs) and include ASK1, ASK2, and MAPKKK15. ASK1 (also called MAPKKK5) functions in the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. It plays important roles in cytokine and stress responses, as well as in reactive oxygen species-mediated cellular responses. ASK1 is implicated in various diseases mediated by oxidative stress including inschemic heart disease, hypertension, vessel injury, brain ischemia, Fanconi anemia, asthma, and pulmonary edema, among others. ASK2 (also called MAPKKK6) functions only in a heteromeric complex with ASK1, and can activate ASK1 by direct phosphorylation. The function of MAPKKK15 is still unknown. The ASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270794 [Multi-domain]  Cd Length: 268  Bit Score: 111.73  E-value: 1.81e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIsPFEHQTYCQRTLREIKILLRFRHENI------IGINDIIRAptieqmkdvyiv 104
Cdd:cd06624  16 LGKGTFGVVYAARDLSTQVRIAIKEI-PERDSREVQPLHEEIALHSRLSHKNIvqylgsVSEDGFFKI------------ 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 qdLMET----DLYKLLKTQ--HLSNDH--ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT-TCDLKICDFG----LA 171
Cdd:cd06624  83 --FMEQvpggSLSALLRSKwgPLKDNEntIGYYTKQILEGLKYLHDNKIVHRDIKGDNVLVNTySGVVKISDFGtskrLA 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 172 RVADPDHDHTGflteyvaTRWYRAPEIMLNS-KGYTKSIDIWSVGCILAEMLSNRPIFPGkhyldqlnhilgiLGSPsqe 250
Cdd:cd06624 161 GINPCTETFTG-------TLQYMAPEVIDKGqRGYGPPADIWSLGCTIIEMATGKPPFIE-------------LGEP--- 217
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 251 dlnciinlKARNYllslphknKVPWNRLFP----NADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06624 218 --------QAAMF--------KVGMFKIHPeipeSLSEEAKSFILRCFEPDPDKRATASDLLQDPFL 268
STKc_FA2-like cd08529
Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar ...
25-244 3.01e-28

Catalytic domain of the Serine/Threonine Kinases, Chlamydomonas reinhardtii FA2 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Chlamydomonas reinhardtii FA2 was discovered in a genetic screen for deflagellation-defective mutants. It is essential for basal-body/centriole-associated microtubule severing, and plays a role in cell cycle progression. No cellular function has yet been ascribed to CNK4. The Chlamydomonas reinhardtii FA2-like subfamily belongs to the (NIMA)-related kinase (Nek) family, which includes seven different Chlamydomonas Neks (CNKs 1-6 and Fa2). This subfamily contains FA2 and CNK4. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270868 [Multi-domain]  Cd Length: 256  Bit Score: 110.58  E-value: 3.01e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYCQR--TLREIKILLRFRHENIIGINDIIraptIEQMKdVY 102
Cdd:cd08529   2 FEILNKLGKGSFGVVYKVVRKVDGRVYALKQID-ISRMSRKMReeAIDEARVLSKLNSPYVIKYYDSF----VDKGK-LN 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMET-DLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpdh 178
Cdd:cd08529  76 IVMEYAENgDLHSLIKSQRgrpLPEDQIWKFFIQTLLGLSHLHSKKILHRDIKSMNIFLDKGDNVKIGDLGVAKILS--- 152
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 179 DHTGFLTEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSnrpifpGKHYLDQLNH---ILGIL 244
Cdd:cd08529 153 DTTNFAQTIVGTPYYLSPE-LCEDKPYNEKSDVWALGCVLYELCT------GKHPFEAQNQgalILKIV 214
STKc_RSK2_C cd14176
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called ...
31-313 6.54e-28

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 2 (also called 90kDa ribosomal protein S6 kinase 3 or Ribosomal protein S6 kinase alpha-3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK2 is also called p90RSK3, RPS6KA3, S6K-alpha-3, or MAPK-activated protein kinase 1b (MAPKAPK-1b). RSK2 is expressed highly in the regions of the brain with high synaptic activity. It plays a role in the maintenance and consolidation of excitatory synapses. It is a specific modulator of phospholipase D in calcium-regulated exocytosis. Mutations in the RSK2 gene, RPS6KA3, cause Coffin-Lowry syndrome (CLS), a rare syndromic form of X-linked mental retardation characterized by growth and psychomotor retardation and skeletal abnormalities. RSK2 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271078 [Multi-domain]  Cd Length: 339  Bit Score: 111.65  E-value: 6.54e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTycqrtLREIKILLRF-RHENIIGINDIIraptiEQMKDVYIVQDLME 109
Cdd:cd14176  27 IGVGSYSVCKRCIHKATNMEFAVKIIDKSKRDP-----TEEIEILLRYgQHPNIITLKDVY-----DDGKYVYVVTELMK 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL----NTTCDLKICDFGLARVADPDHdhtGF 183
Cdd:cd14176  97 GGelLDKILRQKFFSEREASAVLFTITKTVEYLHAQGVVHRDLKPSNILYvdesGNPESIRICDFGFAKQLRAEN---GL 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSN-RPIFPGKHylDQLNHILGILGSPsqedlnciinlkarN 262
Cdd:cd14176 174 LMTPCYTANFVAPEV-LERQGYDAACDIWSLGVLLYTMLTGyTPFANGPD--DTPEEILARIGSG--------------K 236
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 263 YLLSLPHknkvpWNrlfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14176 237 FSLSGGY-----WN----SVSDTAKDLVSKMLHVDPHQRLTAALVLRHPWI 278
STKc_RSK3_C cd14178
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called ...
31-313 7.13e-28

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 3 (also called Ribosomal protein S6 kinase alpha-2 or 90kDa ribosomal protein S6 kinase 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK3 is also called S6K-alpha-2, RPS6KA2, p90RSK2 or MAPK-activated protein kinase 1c (MAPKAPK-1c). RSK3 binds muscle A-kinase anchoring protein (mAKAP)-b directly and regulates concentric cardiac myocyte growth. The RSK3 gene, RPS6KA2, is a putative tumor suppressor gene in sporadic epithelial ovarian cancer and variations to the gene may be associated with rectal cancer risk. RSK3 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271080 [Multi-domain]  Cd Length: 293  Bit Score: 110.49  E-value: 7.13e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYcqrtlREIKILLRF-RHENIIGINDIIraptiEQMKDVYIVQDLME 109
Cdd:cd14178  11 IGIGSYSVCKRCVHKATSTEYAVKIIDKSKRDPS-----EEIEILLRYgQHPNIITLKDVY-----DDGKFVYLVMELMR 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL-LNTTCD---LKICDFGLARVADPDHdhtGF 183
Cdd:cd14178  81 GGelLDRILRQKCFSEREASAVLCTITKTVEYLHSQGVVHRDLKPSNILyMDESGNpesIRICDFGFAKQLRAEN---GL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSN-RPIFPGKHylDQLNHILGILGSPsqedlnciinlkarN 262
Cdd:cd14178 158 LMTPCYTANFVAPEV-LKRQGYDAACDIWSLGILLYTMLAGfTPFANGPD--DTPEEILARIGSG--------------K 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 263 YLLSLPHknkvpWNRLfpnaDSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14178 221 YALSGGN-----WDSI----SDAAKDIVSKMLHVDPHQRLTAPQVLRHPWI 262
STKc_RSK4_C cd14177
C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called ...
31-313 8.99e-28

C-terminal catalytic domain of the Serine/Threonine Kinase, Ribosomal S6 kinase 4 (also called Ribosomal protein S6 kinase alpha-6 or 90kDa ribosomal protein S6 kinase 6); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSK4 is also called S6K-alpha-6, RPS6KA6, p90RSK6 or pp90RSK4. RSK4 is a substrate of ERK and is a modulator of p53-dependent proliferation arrest in human cells. Deletion of the RSK4 gene, RPS6KA6, frequently occurs in patients of X-linked deafness type 3, mental retardation and choroideremia. Studies of RSK4 in cancer cells and tissues suggest that it may be oncogenic or tumor suppressive depending on many factors. RSK4 is one of four RSK isoforms (RSK1-4) from distinct genes present in vertebrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. The RSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271079 [Multi-domain]  Cd Length: 295  Bit Score: 110.49  E-value: 8.99e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYcqrtlREIKILLRF-RHENIIGINDIIraptiEQMKDVYIVQDLME 109
Cdd:cd14177  12 IGVGSYSVCKRCIHRATNMEFAVKIIDKSKRDPS-----EEIEILMRYgQHPNIITLKDVY-----DDGRYVYLVTELMK 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL---NTTCD-LKICDFGLARVADPDHdhtGF 183
Cdd:cd14177  82 GGelLDRILRQKFFSEREASAVLYTITKTVDYLHCQGVVHRDLKPSNILYmddSANADsIRICDFGFAKQLRGEN---GL 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYRAPEIMLNsKGYTKSIDIWSVGCILAEMLSNRPIFPGkhyldqlnhilGILGSPSQedlnciINLKARNY 263
Cdd:cd14177 159 LLTPCYTANFVAPEVLMR-QGYDAACDIWSLGVLLYTMLAGYTPFAN-----------GPNDTPEE------ILLRIGSG 220
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 264 LLSLPHKNkvpWNrlfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14177 221 KFSLSGGN---WD----TVSDAAKDLLSHMLHVDPHQRYTAEQVLKHSWI 263
PKc_Pek1_like cd06621
Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
28-313 9.95e-28

Catalytic domain of fungal Pek1-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Pek1/Skh1 from Schizosaccharomyces pombe and MKK2 from Saccharomyces cerevisiae, and related proteins. Both fission yeast Pek1 and baker's yeast MKK2 are components of the cell integrity MAPK pathway. In fission yeast, Pek1 phosphorylates and activates Pmk1/Spm1 and is regulated by the MAPKK kinase Mkh1. In baker's yeast, the pathway involves the MAPK Slt2, the MAPKKs MKK1 and MKK2, and the MAPKK kinase Bck1. The cell integrity MAPK cascade is activated by multiple stress conditions, and is essential in cell wall construction, morphogenesis, cytokinesis, and ion homeostasis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270793 [Multi-domain]  Cd Length: 287  Bit Score: 110.20  E-value: 9.95e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIginDIIRAPTIEQMKDVYIVQDL 107
Cdd:cd06621   6 LSSLGEGAGGSVTKCRLRNTKTIFALKTITTDPNPDVQKQILRELEINKSCASPYIV---KYYGAFLDEQDSSIGIAMEY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 MET----DLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHT 181
Cdd:cd06621  83 CEGgsldSIYKKVKKKggRIGEKVLGKIAESVLKGLSYLHSRKIIHRDIKPSNILLTRKGQVKLCDFGVSGELVNSLAGT 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 gflteYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhyldqlnhilgilGSPSQ---EDLNCIINL 258
Cdd:cd06621 163 -----FTGTSYYMAPE-RIQGGPYSITSDVWSLGLTLLEVAQNRFPFPPE-------------GEPPLgpiELLSYIVNM 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 259 KarNYLLSLPHKNKVPWNRLFPnadskalDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06621 224 P--NPELKDEPENGIKWSESFK-------DFIEKCLEKDGTRRPGPWQMLAHPWI 269
STKc_Pat1_like cd13993
Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of ...
24-302 1.54e-27

Catalytic domain of Fungal Pat1-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Pat1 (also called Ran1), Saccharomyces cerevisiae VHS1 and KSP1, and similar fungal STKs. Pat1 blocks Mei2, an RNA-binding protein which is indispensable in the initiation of meiosis. Pat1 is inactivated and Mei2 activated, which initiates meiosis, under nutrient-deprived conditions through a signaling cascade involving Ste11. Meiosis induced by Pat1 inactivation may show different characteristics than normal meiosis including aberrant positioning of centromeres. VHS1 was identified in a screen for suppressors of cell cycle arrest at the G1/S transition, while KSP1 may be involved in regulating PRP20, which is required for mRNA export and maintenance of nuclear structure. The Pat1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270895 [Multi-domain]  Cd Length: 267  Bit Score: 108.98  E-value: 1.54e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQT------YCQRTLREIKILLRF-RHENIIGINDIIraptiE 96
Cdd:cd13993   1 RYQLISPIGEGAYGVVYLAVDLRTGRKYAIKCLYKSGPNSkdgndfQKLPQLREIDLHRRVsRHPNIITLHDVF-----E 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 QMKDVYIVQDLME-TDLYKLL---KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD-LKICDFGLA 171
Cdd:cd13993  76 TEVAIYIVLEYCPnGDLFEAItenRIYVGKTELIKNVFLQLIDAVKHCHSLGIYHRDIKPENILLSQDEGtVKLCDFGLA 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 172 RVADPDHDHTgflteyVATRWYRAPEIMLN----SKGY-TKSIDIWSVGCILAEMLSNRPIFPgkhyldqlnhilgilgS 246
Cdd:cd13993 156 TTEKISMDFG------VGSEFYMAPECFDEvgrsLKGYpCAAGDIWSLGIILLNLTFGRNPWK----------------I 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 247 PSQEDLNCIINLKARNYLLslphknkvpwnRLFPNADSKALDLLDKMLTFNPHKRI 302
Cdd:cd13993 214 ASESDPIFYDYYLNSPNLF-----------DVILPMSDDFYNLLRQIFTVNPNNRI 258
STKc_TSSK1_2-like cd14165
Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; ...
31-313 1.58e-27

Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK1 and TSSK2 are expressed specifically in meiotic and postmeiotic spermatogenic cells, respectively. TSSK2 is localized in the sperm neck, equatorial segment, and mid-piece of the sperm tail. Both TSSK1 and TSSK2 phosphorylate their common substrate TSKS (testis-specific-kinase-substrate). TSSK1/TSSK2 double knock-out mice are sterile without manifesting other defects, making these kinases viable targets for male contraception. The TSSK1/2-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271067 [Multi-domain]  Cd Length: 263  Bit Score: 109.10  E-value: 1.58e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIK----KISPfehQTYCQRTL-REIKILLRFRHENIIGINDIIRAPTieqmKDVYIVQ 105
Cdd:cd14165   9 LGEGSYAKVKSAYSERLKCNVAIKiidkKKAP---DDFVEKFLpRELEILARLNHKSIIKTYEIFETSD----GKVYIVM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMET-DLYKLLKTQHLSNDHI--CYFlYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG 182
Cdd:cd14165  82 ELGVQgDLLEFIKLRGALPEDVarKMF-HQLSSAIKYCHELDIVHRDLKCENLLLDKDFNIKLTDFGFSKRCLRDENGRI 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 183 FLTE-YVATRWYRAPEImLNSKGYTKSI-DIWSVGCILAEMLsnrpifpgkhyldqlnhilgiLGSPSQEDLNCIINLKa 260
Cdd:cd14165 161 VLSKtFCGSAAYAAPEV-LQGIPYDPRIyDIWSLGVILYIMV---------------------CGSMPYDDSNVKKMLK- 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 261 rnylLSLPHKNKVPWNRlfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14165 218 ----IQKEHRVRFPRSK---NLTSECKDLIYRLLQPDVSQRLCIDEVLSHPWL 263
PTKc cd00192
Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
30-224 1.91e-27

Catalytic domain of Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. They can be classified into receptor and non-receptor tyr kinases. PTKs play important roles in many cellular processes including, lymphocyte activation, epithelium growth and maintenance, metabolism control, organogenesis regulation, survival, proliferation, differentiation, migration, adhesion, motility, and morphogenesis. Receptor tyr kinases (RTKs) are integral membrane proteins which contain an extracellular ligand-binding region, a transmembrane segment, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain, leading to intracellular signaling. Some RTKs are orphan receptors with no known ligands. Non-receptor (or cytoplasmic) tyr kinases are distributed in different intracellular compartments and are usually multi-domain proteins containing a catalytic tyr kinase domain as well as various regulatory domains such as SH3 and SH2. PTKs are usually autoinhibited and require a mechanism for activation. In many PTKs, the phosphorylation of tyr residues in the activation loop is essential for optimal activity. Aberrant expression of PTKs is associated with many development abnormalities and cancers.The PTK family is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270623 [Multi-domain]  Cd Length: 262  Bit Score: 108.78  E-value: 1.91e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  30 YIGEGAYGMVCSAY---DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGIndiIRAPTIEQMkdVYIVQD 106
Cdd:cd00192   2 KLGEGAFGEVYKGKlkgGDGKTVDVAVKTLKEDASESERKDFLKEARVMKKLGHPNVVRL---LGVCTEEEP--LYLVME 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LME-TDLYKLLKT----------QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARvad 175
Cdd:cd00192  77 YMEgGDLLDFLRKsrpvfpspepSTLSLKDLLSFAIQIAKGMEYLASKKFVHRDLAARNCLVGEDLVVKISDFGLSR--- 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 176 pDHDHTGfltEYVAT-------RWYrAPEiMLNSKGYT-KSiDIWSVGCILAEMLSN 224
Cdd:cd00192 154 -DIYDDD---YYRKKtggklpiRWM-APE-SLKDGIFTsKS-DVWSFGVLLWEIFTL 203
STKc_HAL4_like cd13994
Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs ...
31-313 2.11e-27

Catalytic domain of Fungal Halotolerance protein 4-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of HAL4, Saccharomyces cerevisiae Ptk2/Stk2, and similar fungal proteins. Proteins in this subfamily are involved in regulating ion transporters. In budding and fission yeast, HAL4 promotes potassium ion uptake, which increases cellular resistance to other cations such as sodium, lithium, and calcium ions. HAL4 stabilizes the major high-affinity K+ transporter Trk1 at the plasma membrane under low K+ conditions, which prevents endocytosis and vacuolar degradation. Budding yeast Ptk2 phosphorylates and regulates the plasma membrane H+ ATPase, Pma1. The HAL4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270896 [Multi-domain]  Cd Length: 265  Bit Score: 108.55  E-value: 2.11e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMV--CSAYDNVNKVRVAIK---KISPFEHQT-YCQRTLREIKILLRFRHENIIGINDIIRAPTIEqmkdVYIV 104
Cdd:cd13994   1 IGKGATSVVriVTKKNPRSGVLYAVKeyrRRDDESKRKdYVKRLTSEYIISSKLHHPNIVKVLDLCQDLHGK----WCLV 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMET-DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG 182
Cdd:cd13994  77 MEYCPGgDLFTLIEKAdSLSLEEKDCFFKQILRGVAYLHSHGIAHRDLKPENILLDEDGVLKLTDFGTAEVFGMPAEKES 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 183 FLTE-YVATRWYRAPEIMlNSKGYT-KSIDIWSVGCILAEMLSNRpiFPGKHyldqlnhilgilgsPSQEDLNCIINLKA 260
Cdd:cd13994 157 PMSAgLCGSEPYMAPEVF-TSGSYDgRAVDVWSCGIVLFALFTGR--FPWRS--------------AKKSDSAYKAYEKS 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 261 RNYLLSLPhknkVPWNRLFPnadSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd13994 220 GDFTNGPY----EPIENLLP---SECRRLIYRMLHPDPEKRITIDEALNDPWV 265
STKc_MEKK4 cd06626
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
24-313 2.58e-27

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK4 is a MAPK kinase kinase that phosphorylates and activates the c-Jun N-terminal kinase (JNK) and p38 MAPK signaling pathways by directly activating their respective MAPKKs, MKK4/MKK7 and MKK3/MKK6. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. MEKK4 also plays roles in the re-polarization of the actin cytoskeleton in response to osmotic stress, in the proper closure of the neural tube, in cardiovascular development, and in immune responses. The MEKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270796 [Multi-domain]  Cd Length: 265  Bit Score: 108.54  E-value: 2.58e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS--PFEHQTYcQRTLREIKILLRFRHENIIgindiiRAPTIEQMKD- 100
Cdd:cd06626   1 RWQRGNKIGEGTFGKVYTAVNLDTGELMAMKEIRfqDNDPKTI-KEIADEMKVLEGLDHPNLV------RYYGVEVHREe 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLM-ETDLYKLLK-TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-RVADPD 177
Cdd:cd06626  74 VYIFMEYCqEGTLEELLRhGRILDEAVIRVYTLQLLEGLAYLHENGIVHRDIKPANIFLDSNGLIKLGDFGSAvKLKNNT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 --HDHtGFLTEYVATRWYRAPEIMLNSK--GYTKSIDIWSVGCILAEMLSNRPIFpgkHYLD---QLNHILGILGSPsqe 250
Cdd:cd06626 154 ttMAP-GEVNSLVGTPAYMAPEVITGNKgeGHGRAADIWSLGCVVLEMATGKRPW---SELDnewAIMYHVGMGHKP--- 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 251 dlnciinlkarnyllSLPHKNKVpwnrlfpnaDSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06626 227 ---------------PIPDSLQL---------SPEGKDFLSRCLESDPKKRPTASELLDHPFI 265
PKc_CLK1_4 cd14213
Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4; ...
24-313 2.97e-27

Catalytic domain of the Dual-specificity protein kinases, CDC-like kinases 1 and 4; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. CLK1 plays a role in neuronal differentiation. CLKs are involved in the phosphorylation and regulation of serine/arginine-rich (SR) proteins, which play a crucial role in pre-mRNA splicing by directing splice site selection. SR proteins are phosphorylated first by SR protein kinases (SRPKs) at the N-terminus, which leads to its assembly into nuclear speckles where splicing factors are stored. CLKs phosphorylate the C-terminal part of SR proteins, causing the nuclear speckles to dissolve and splicing factors to be recruited at sites of active transcription. Based on a conserved "EHLAMMERILG" signature motif which may be crucial for substrate specificity, CLKs are also referred to as LAMMER kinases. CLKs autophosphorylate at tyrosine residues and phosphorylate their substrates exclusively on serine/threonine residues. The CLK1/4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271115 [Multi-domain]  Cd Length: 330  Bit Score: 109.56  E-value: 2.97e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYD-NVNKVRVAIKKISPFEHqtYCQRTLREIKILlrfRHENIIGINDIIRAPTIEQMKD-- 100
Cdd:cd14213  13 RYEIVDTLGEGAFGKVVECIDhKMGGMHVAVKIVKNVDR--YREAARSEIQVL---EHLNTTDPNSTFRCVQMLEWFDhh 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 --VYIVQDLMETDLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL---------NTT------ 160
Cdd:cd14213  88 ghVCIVFELLGLSTYDFIKEnsfLPFPIDHIRNMAYQICKSVNFLHHNKLTHTDLKPENILFvqsdyvvkyNPKmkrder 167
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 161 ----CDLKICDFGLARVADPDHdhtgflTEYVATRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPIFP---GKHY 233
Cdd:cd14213 168 tlknPDIKVVDFGSATYDDEHH------STLVSTRHYRAPEVIL-ALGWSQPCDVWSIGCILIEYYLGFTVFQthdSKEH 240
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 234 LDQLNHILGILgspsqeDLNCIINLKARNYLlslpHKNKVPWNR-------------------LFPNADSKAL-DLLDKM 293
Cdd:cd14213 241 LAMMERILGPL------PKHMIQKTRKRKYF----HHDQLDWDEhssagryvrrrckplkefmLSQDVDHEQLfDLIQKM 310
                       330       340
                ....*....|....*....|
gi 66932916 294 LTFNPHKRIEVEQALAHPYL 313
Cdd:cd14213 311 LEYDPAKRITLDEALKHPFF 330
STKc_Nek1 cd08218
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
24-223 3.15e-27

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek1 is associated with centrosomes throughout the cell cycle. It is involved in the formation of primary cilium and in the maintenance of centrosomes. It cycles through the nucleus and may be capable of relaying signals between the cilium and the nucleus. Nek1 is implicated in the development of polycystic kidney disease, which is characterized by benign polycystic tumors formed by abnormal overgrowth of renal epithelial cells. It appears also to be involved in DNA damage response, and may be important for both correct DNA damage checkpoint activation and DNA repair. Nek1 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270858 [Multi-domain]  Cd Length: 256  Bit Score: 107.97  E-value: 3.15e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYG---MVCSAYDNVNKV--RVAIKKISPFEHQtycqRTLREIKILLRFRHENIIGINDiirapTIEQM 98
Cdd:cd08218   1 KYVRIKKIGEGSFGkalLVKSKEDGKQYVikEINISKMSPKERE----ESRKEVAVLSKMKHPNIVQYQE-----SFEEN 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLMET-DLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVA 174
Cdd:cd08218  72 GNLYIVMDYCDGgDLYKRINAQRgvlFPEDQILDWFVQLCLALKHVHDRKILHRDIKSQNIFLTKDGIIKLGDFGIARVL 151
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 175 dpdhDHTGFLTE-YVATRWYRAPEIMLNsKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd08218 152 ----NSTVELARtCIGTPYYLSPEICEN-KPYNNKSDIWALGCVLYEMCT 196
STKc_EIF2AK4_GCN2_rpt2 cd14046
Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation ...
24-310 3.56e-27

Catalytic domain, repeat 2, of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GCN2 (or EIF2AK4) is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. Its kinase domain is activated via conformational changes as a result of the binding of uncharged tRNA to the HisRS-like domain. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270948 [Multi-domain]  Cd Length: 278  Bit Score: 108.23  E-value: 3.56e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTN----LSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIgindiiRAPT--IEQ 97
Cdd:cd14046   3 RYLTdfeeLQVLGKGAFGQVVKVRNKLDGRYYAIKKIKLRSESKNNSRILREVMLLSRLNHQHVV------RYYQawIER 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  98 mKDVYIVQDLMETD-LYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR--- 172
Cdd:cd14046  77 -ANLYIQMEYCEKStLRDLIDSGlFQDTDRLWRLFRQILEGLAYIHSQGIIHRDLKPVNIFLDSNGNVKIGDFGLATsnk 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 ---------VADPD---HDHTGFLTEYVATRWYRAPEIMLNSKG-YTKSIDIWSVGCILAEMlsnrpIFPGKHYLDQLnH 239
Cdd:cd14046 156 lnvelatqdINKSTsaaLGSSGDLTGNVGTALYVAPEVQSGTKStYNEKVDMYSLGIIFFEM-----CYPFSTGMERV-Q 229
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916 240 ILGILGSPSQEdlnciinlkarnyllsLPHKnkvpwnrlFPNAD-SKALDLLDKMLTFNPHKRIEVEQALAH 310
Cdd:cd14046 230 ILTALRSVSIE----------------FPPD--------FDDNKhSKQAKLIRWLLNHDPAKRPSAQELLKS 277
STKc_SRPK cd14136
Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze ...
16-313 5.13e-27

Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. They play important roles in mediating pre-mRNA processing and mRNA maturation, as well as other cellular functions such as chromatin reorganization, cell cycle and p53 regulation, and metabolic signaling. Vertebrates contain three distinct SRPKs, called SRPK1-3. The SRPK homolog in budding yeast, Sky1p, recognizes and phosphorylates its substrate Npl3p, which lacks a classic RS domain but contains a single RS dipeptide at the C-terminus of its RGG domain. Npl3p is a shuttling heterogeneous nuclear ribonucleoprotein (hnRNP) that exports a distinct class of mRNA from the nucleus to the cytoplasm. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271038 [Multi-domain]  Cd Length: 320  Bit Score: 108.82  E-value: 5.13e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  16 GQVFDvgPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHqtYCQRTLREIKILLRFRH--------ENIIGIN 87
Cdd:cd14136   5 GEVYN--GRYHVVRKLGWGHFSTVWLCWDLQNKRFVALKVVKSAQH--YTEAALDEIKLLKCVREadpkdpgrEHVVQLL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  88 D--IIRAPtieQMKDVYIVQDLMETDLYKLLKtqhLSNDH---------ICyflYQILRGLKYIHS-ANVLHRDLKPSNL 155
Cdd:cd14136  81 DdfKHTGP---NGTHVCMVFEVLGPNLLKLIK---RYNYRgiplplvkkIA---RQVLQGLDYLHTkCGIIHTDIKPENV 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 156 LLN-TTCDLKICDFGLARVAdpdHDHtgfLTEYVATRWYRAPEIMLNSkGYTKSIDIWSVGCILAEMLSNRPIF---PGK 231
Cdd:cd14136 152 LLCiSKIEVKIADLGNACWT---DKH---FTEDIQTRQYRSPEVILGA-GYGTPADIWSTACMAFELATGDYLFdphSGE 224
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 232 HYL---DQLNHILGILG------------SP----SQEDLNCIINLKARNYLLSLPHKNKvpwnrlFPNADSKAL-DLLD 291
Cdd:cd14136 225 DYSrdeDHLALIIELLGriprsiilsgkySReffnRKGELRHISKLKPWPLEDVLVEKYK------WSKEEAKEFaSFLL 298
                       330       340
                ....*....|....*....|..
gi 66932916 292 KMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14136 299 PMLEYDPEKRATAAQCLQHPWL 320
STKc_TAO cd06607
Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs ...
24-315 6.24e-27

Catalytic domain of the Serine/Threonine Kinases, Thousand-and-One Amino acids proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. They activate the MAPKs, p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating the respective MAP/ERK kinases (MEKs, also known as MKKs or MAPKKs), MEK3/MEK6 and MKK4/MKK7. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. Vertebrates contain three TAO subfamily members, named TAO1, TAO2, and TAO3. The TAO subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270784 [Multi-domain]  Cd Length: 258  Bit Score: 107.15  E-value: 6.24e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTY--CQRTLREIKILLRFRHENIIgindiiraptieQMKDV 101
Cdd:cd06607   2 IFEDLREIGHGSFGAVYYARNKRTSEVVAIKKMSYSGKQSTekWQDIIKEVKFLRQLRHPNTI------------EYKGC 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQD----LME------TDLYKLLKtQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA 171
Cdd:cd06607  70 YLREHtawlVMEyclgsaSDIVEVHK-KPLQEVEIAAICHGALQGLAYLHSHNRIHRDVKAGNILLTEPGTVKLADFGSA 148
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 172 RVADPdhdhtgfLTEYVATRWYRAPEIML--NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsq 249
Cdd:cd06607 149 SLVCP-------ANSFVGTPYWMAPEVILamDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI--------- 212
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 250 edlnciinlkARNYLLSLPhknKVPWNRLFPNadskaldLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
Cdd:cd06607 213 ----------AQNDSPTLS---SGEWSDDFRN-------FVDSCLQKIPQDRPSAEDLLKHPFVTR 258
STKc_HIPK1 cd14228
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1; ...
25-313 7.28e-27

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPK1 has been implicated in regulating eye size, lens formation, and retinal morphogenesis during late embryogenesis. It also contributes to the regulation of haematopoiesis and leukaemogenesis by phosphorylating and repressing the transcription factor c-Myb, which is crucial in T- and B-cell development. In glucose-deprived conditions, HIPK1 phosphorylates Daxx, leading to its relocalization from the nucleus to the cytoplasm, where it binds and stabilizes ASK1 (apoptosis signal-regulating kinase 1), a mitogen-activated protein kinase (MAPK) kinase kinase that activates the JNK and p38 MAPK pathways. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). The HIPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271130 [Multi-domain]  Cd Length: 355  Bit Score: 109.02  E-value: 7.28e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIV 104
Cdd:cd14228  17 YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILK--NHPSYARQGQIEVSILSRLSSENADEYNFVRSYECFQHKNHTCLV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETDLYKLLKTQHLSNDHICYF---LYQILRGLKYIHSANVLHRDLKPSNLLL----NTTCDLKICDFGLArvadpD 177
Cdd:cd14228  95 FEMLEQNLYDFLKQNKFSPLPLKYIrpiLQQVATALMKLKSLGLIHADLKPENIMLvdpvRQPYRVKVIDFGSA-----S 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HDHTGFLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI----------------- 240
Cdd:cd14228 170 HVSKAVCSTYLQSRYYRAPEIILGLP-FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYIsqtqglpaeyllsagtk 248
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 241 --------------LGILGSPSQEDLNCIINLK-ARNYLLS-LPHKNKVPWNRLFPNADSKA--------LDLLDKMLTF 296
Cdd:cd14228 249 tsrffnrdpnlgypLWRLKTPEEHELETGIKSKeARKYIFNcLDDMAQVNMSTDLEGTDMLAekadrreyIDLLKKMLTI 328
                       330
                ....*....|....*..
gi 66932916 297 NPHKRIEVEQALAHPYL 313
Cdd:cd14228 329 DADKRITPLKTLNHPFV 345
STKc_NAK1_like cd06917
Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
25-226 8.55e-27

Catalytic domain of Fungal Nak1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Nak1, Saccharomyces cerevisiae Kic1p (kinase that interacts with Cdc31p) and related proteins. Nak1 (also called N-rich kinase 1), is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Kic1p is required by budding yeast for cell integrity and morphogenesis. Kic1p interacts with Cdc31p, the yeast homologue of centrin, and phosphorylates substrates in a Cdc31p-dependent manner. The Nak1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270822 [Multi-domain]  Cd Length: 277  Bit Score: 107.18  E-value: 8.55e-27
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH---ENIIGI-NDIIRAPTieqmkd 100
Cdd:cd06917   3 YRRLELVGRGSYGAVYRGYHVKTGRVVALKVLNLDTDDDDVSDIQKEVALLSQLKLgqpKNIIKYyGSYLKGPS------ 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLMET-DLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGlarVADPDHD 179
Cdd:cd06917  77 LWIIMDYCEGgSIRTLMRAGPIAERYIAVIMREVLVALKFIHKDGIIHRDIKAANILVTNTGNVKLCDFG---VAASLNQ 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 180 HTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRP 226
Cdd:cd06917 154 NSSKRSTFVGTPYWMAPEVITEGKYYDTKADIWSLGITTYEMATGNP 200
STKc_HIPK2 cd14227
Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2; ...
25-313 1.04e-26

Catalytic domain of the Serine/Threonine Kinase, Homeodomain-Interacting Protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HIPK2, the most studied HIPK, is a coregulator of many transcription factors and cofactors including homeodomain proteins (Nkx and HOX families), Smad1-4, Pax6, c-Myb, AML1, the histone acetyltransferase p300, and the tumor repressor p53, among others. It regulates gene transcription during development and in DNA damage response (DDR), and mediates cell processes such as apoptosis, survival, differentiation, and proliferation. HIPK2 mediates apoptosis by phosphorylating and activating p53 during DDR, resulting in the activation of apoptotic genes. In the absence of p53, HIPK2 targets the anti-apoptotic corepressor C-terminal binding protein (CtBP), leading to CtBP's degradation and the promotion of apoptosis. HIPKs, originally identified by their ability to bind homeobox factors, are nuclear proteins containing catalytic kinase and homeobox-interacting domains as well as a PEST region overlapping with the speckle-retention signal (SRS). The HIPK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271129 [Multi-domain]  Cd Length: 355  Bit Score: 108.64  E-value: 1.04e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINdIIRAPTIEQMKD-VYI 103
Cdd:cd14227  17 YEVLEFLGRGTFGQVVKCWKRGTNEIVAIKILK--NHPSYARQGQIEVSILARLSTESADDYN-FVRAYECFQHKNhTCL 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLKTQHLSNDHICYF---LYQILRGLKYIHSANVLHRDLKPSNLLL----NTTCDLKICDFGLArvadp 176
Cdd:cd14227  94 VFEMLEQNLYDFLKQNKFSPLPLKYIrpiLQQVATALMKLKSLGLIHADLKPENIMLvdpsRQPYRVKVIDFGSA----- 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 DHDHTGFLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNC-- 254
Cdd:cd14227 169 SHVSKAVCSTYLQSRYYRAPEIILGLP-FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAgt 247
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 255 ------------------------------IINLKARNYLLS-LPHKNKVPW-------NRLFPNADSKA-LDLLDKMLT 295
Cdd:cd14227 248 kttrffnrdtdspyplwrlktpedheaetgIKSKEARKYIFNcLDDMAQVNMttdlegsDMLVEKADRREfIDLLKKMLT 327
                       330
                ....*....|....*...
gi 66932916 296 FNPHKRIEVEQALAHPYL 313
Cdd:cd14227 328 IDADKRITPIETLNHPFV 345
STKc_CaMKI_alpha cd14167
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
31-313 1.21e-26

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271069 [Multi-domain]  Cd Length: 263  Bit Score: 106.65  E-value: 1.21e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLMET 110
Cdd:cd14167  11 LGTGAFSEVVLAEEKRTQKLVAIKCIAKKALEGKETSIENEIAVLHKIKHPNIVALDDIY-----ESGGHLYLIMQLVSG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 -DLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL---LNTTCDLKICDFGLARVADPDhdhtGFLT 185
Cdd:cd14167  86 gELFdRIVEKGFYTERDASKLIFQILDAVKYLHDMGIVHRDLKPENLLyysLDEDSKIMISDFGLSKIEGSG----SVMS 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 EYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqedlnciinLKARnYLL 265
Cdd:cd14167 162 TACGTPGYVAPEV-LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQI-----------------LKAE-YEF 222
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 66932916 266 SLPHknkvpWNRLfpnADSkALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14167 223 DSPY-----WDDI---SDS-AKDFIQHLMEKDPEKRFTCEQALQHPWI 261
STKc_OSR1_SPAK cd06610
Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and ...
31-312 1.56e-26

Catalytic domain of the Serine/Threonine Kinases, Oxidative stress response kinase and Ste20-related proline alanine-rich kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SPAK is also referred to as STK39 or PASK (proline-alanine-rich STE20-related kinase). OSR1 and SPAK regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. They are also implicated in cytoskeletal rearrangement, cell differentiation, transformation and proliferation. OSR1 and SPAK contain a conserved C-terminal (CCT) domain, which recognizes a unique motif ([RK]FX[VI]) present in their activating kinases (WNK1/WNK4) and their substrates. The OSR1 and SPAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270787 [Multi-domain]  Cd Length: 267  Bit Score: 106.29  E-value: 1.56e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGindiirAPTIEQMKDV-YIVQDLME 109
Cdd:cd06610   9 IGSGATAVVYAAYCLPKKEKVAIKRIDLEKCQTSMDELRKEIQAMSQCNHPNVVS------YYTSFVVGDElWLVMPLLS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 T-DLYKLLKTQH----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGL-ARVADPDHDHTGF 183
Cdd:cd06610  83 GgSLLDIMKSSYprggLDEAIIATVLKEVLKGLEYLHSNGQIHRDVKAGNILLGEDGSVKIADFGVsASLATGGDRTRKV 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPifPGKHYldqlnhilgilgSPSQedlncIINLKARNY 263
Cdd:cd06610 163 RKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAIELATGAA--PYSKY------------PPMK-----VLMLTLQND 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 264 LLSLPHknkvpwnrlfpNADSKAL-----DLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd06610 224 PPSLET-----------GADYKKYsksfrKMISLCLQKDPSKRPTAEELLKHKF 266
STKc_PDK1 cd05581
Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs ...
30-312 1.65e-26

Catalytic domain of the Serine/Threonine Kinase, Phosphoinositide-dependent kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDK1 carries an N-terminal catalytic domain and a C-terminal pleckstrin homology (PH) domain that binds phosphoinositides. It phosphorylates the activation loop of AGC kinases that are regulated by PI3K such as PKB, SGK, and PKC, among others, and is crucial for their activation. Thus, it contributes in regulating many processes including metabolism, growth, proliferation, and survival. PDK1 also has the ability to autophosphorylate and is constitutively active in mammalian cells. It is essential for normal embryo development and is important in regulating cell volume. The PDK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270733 [Multi-domain]  Cd Length: 278  Bit Score: 106.53  E-value: 1.65e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  30 YIGEGAYGMVCSAYDNVNKVRVAIKKISPfehqtycQRTLREIK---------ILLRFRHENIIGIndiirAPTIEQMKD 100
Cdd:cd05581   8 PLGEGSYSTVVLAKEKETGKEYAIKVLDK-------RHIIKEKKvkyvtiekeVLSRLAHPGIVKL-----YYTFQDESK 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLMET-DLYKLLKtQHLSNDHIC--YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPD 177
Cdd:cd05581  76 LYFVLEYAPNgDLLEYIR-KYGSLDEKCtrFYTAEIVLALEYLHSKGIIHRDLKPENILLDEDMHIKITDFGTAKVLGPD 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HDHTGFLTEY--------------VATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgi 243
Cdd:cd05581 155 SSPESTKGDAdsqiaynqaraasfVGTAEYVSPE-LLNEKPAGKSSDLWALGCIIYQMLTGKPPFRGSNEYLTFQKIV-- 231
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 244 lgspsqedlnciinlkARNYllSLPHKnkvpwnrlFPNAdskALDLLDKMLTFNPHKRIEV------EQALAHPY 312
Cdd:cd05581 232 ----------------KLEY--EFPEN--------FPPD---AKDLIQKLLVLDPSKRLGVnenggyDELKAHPF 277
STKc_Nek6_7 cd08224
Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related ...
24-238 1.67e-26

Catalytic domain of the Serine/Threonine Kinases, Never In Mitosis gene A (NIMA)-related kinase 6 and 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 and Nek7 are the shortest Neks, consisting only of the catalytic domain and a very short N-terminal extension. They show distinct expression patterns and both appear to be downstream substrates of Nek9. They are required for mitotic spindle formation and cytokinesis. They may also be regulators of the p70 ribosomal S6 kinase. Nek6/7 is part of a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270863 [Multi-domain]  Cd Length: 262  Bit Score: 106.20  E-value: 1.67e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE--HQTYCQRTLREIKILLRFRHENIIGINDIIraptIEQmKDV 101
Cdd:cd08224   1 NYEIEKKIGKGQFSVVYRARCLLDGRLVALKKVQIFEmmDAKARQDCLKEIDLLQQLNHPNIIKYLASF----IEN-NEL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMET-DLYKLLKT-----QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD 175
Cdd:cd08224  76 NIVLELADAgDLSRLIKHfkkqkRLIPERTIWKYFVQLCSALEHMHSKRIMHRDIKPANVFITANGVVKLGDLGLGRFFS 155
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 176 PdhdHTGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhYLDQLN 238
Cdd:cd08224 156 S---KTTAAHSLVGTPYYMSPER-IREQGYDFKSDIWSLGCLLYEMAALQSPF----YGEKMN 210
STKc_Nek5 cd08225
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
24-237 1.70e-26

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. The specific function of Nek5 is unknown. Nek5 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173765 [Multi-domain]  Cd Length: 257  Bit Score: 105.81  E-value: 1.70e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS----PFEHQTYCQRtlrEIKILLRFRHENIIGINDiirapTIEQMK 99
Cdd:cd08225   1 RYEIIKKIGEGSFGKIYLAKAKSDSEHCVIKEIDltkmPVKEKEASKK---EVILLAKMKHPNIVTFFA-----SFQENG 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 DVYIVQDLMET-DLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL-KICDFGLARVA 174
Cdd:cd08225  73 RLFIVMEYCDGgDLMKRINRQRgvlFSEDQILSWFVQISLGLKHIHDRKILHRDIKSQNIFLSKNGMVaKLGDFGIARQL 152
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 175 DpdhDHTGFLTEYVATRWYRAPEIMLNsKGYTKSIDIWSVGCILAEMLSNRPIFPGKHyLDQL 237
Cdd:cd08225 153 N---DSMELAYTCVGTPYYLSPEICQN-RPYNNKTDIWSLGCVLYELCTLKHPFEGNN-LHQL 210
STKc_ULK1_2-like cd14120
Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar ...
31-312 2.16e-26

Catalytic domain of the Serine/Threonine kinases, Unc-51-like kinases 1 and 2, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. ULK2 is ubiquitously expressed and is essential in autophagy induction. ULK1 and ULK2 have unique and cell-type specific roles, but also display partially redundant roles in starvation-induced autophagy. They both display neuron-specific functions: ULK1 is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, and axon branching; ULK2 plays a role in axon development. The ULK1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271022 [Multi-domain]  Cd Length: 256  Bit Score: 105.53  E-value: 2.16e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSA-YDNVNKVRVAIKKISPfEHQTYCQRTL-REIKILLRFRHENIIGINDIIRAPTieqmkDVYIVqdlM 108
Cdd:cd14120   1 IGHGAFAVVFKGrHRKKPDLPVAIKCITK-KNLSKSQNLLgKEIKILKELSHENVVALLDCQETSS-----SVYLV---M 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET----DLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---------LKICDFGLARva 174
Cdd:cd14120  72 EYcnggDLADYLQAKGtLSEDTIRVFLQQIAAAMKALHSKGIVHRDLKPQNILLSHNSGrkpspndirLKIADFGFAR-- 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 175 dpdhdhtgFLTEYV--ATR----WYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhyldQLNhilgilgSPS 248
Cdd:cd14120 150 --------FLQDGMmaATLcgspMYMAPEVIM-SLQYDAKADLWSIGTIVYQCLTGKAPF-------QAQ-------TPQ 206
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 249 QedlnciinlkarnyLLSLPHKNKvpwnRLFPN---ADSKAL-DLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14120 207 E--------------LKAFYEKNA----NLRPNipsGTSPALkDLLLGLLKRNPKDRIDFEDFFSHPF 256
STKc_MST3_like cd06609
Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs ...
24-316 2.24e-26

Catalytic domain of Mammalian Ste20-like protein kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of MST3, MST4, STK25, Schizosaccharomyces pombe Nak1 and Sid1, Saccharomyces cerevisiae sporulation-specific protein 1 (SPS1), and related proteins. Nak1 is required by fission yeast for polarizing the tips of actin cytoskeleton and is involved in cell growth, cell separation, cell morphology and cell-cycle progression. Sid1 is a component in the septation initiation network (SIN) signaling pathway, and plays a role in cytokinesis. SPS1 plays a role in regulating proteins required for spore wall formation. MST4 plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. STK25 may play a role in the regulation of cell migration and polarization. The MST3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270786 [Multi-domain]  Cd Length: 274  Bit Score: 106.18  E-value: 2.24e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILlrfrheniigindiiraptiEQMKDVYI 103
Cdd:cd06609   2 LFTLLERIGKGSFGEVYKGIDKRTNQVVAIKVIDLEEAEDEIEDIQQEIQFL--------------------SQCDSPYI 61
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQD------------LME----TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICD 167
Cdd:cd06609  62 TKYygsflkgsklwiIMEycggGSVLDLLKPGPLDETYIAFILREVLLGLEYLHSEGKIHRDIKAANILLSEEGDVKLAD 141
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 168 FGLArvadpdhdhtGFLTE-------YVATRWYRAPEIMLNSkGYTKSIDIWSVGCILAEMLSnrpifpgkhyldqlnhi 240
Cdd:cd06609 142 FGVS----------GQLTStmskrntFVGTPFWMAPEVIKQS-GYDEKADIWSLGITAIELAK----------------- 193
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 241 lgilGSPSQEDLNciiNLKArnylLSLPHKNKVPwnRLFPNADSKAL-DLLDKMLTFNPHKRIEVEQALAHPYLEQY 316
Cdd:cd06609 194 ----GEPPLSDLH---PMRV----LFLIPKNNPP--SLEGNKFSKPFkDFVELCLNKDPKERPSAKELLKHKFIKKA 257
STKc_PhKG2 cd14181
Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit; STKs ...
46-313 2.30e-26

Catalytic domain of the Serine/Threonine Kinase, Phosphorylase kinase Gamma 2 subunit; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phosphorylase kinase (PhK) catalyzes the phosphorylation of inactive phosphorylase b to form the active phosphorylase a. It coordinates hormonal, metabolic, and neuronal signals to initiate the breakdown of glycogen stores, which enables the maintenance of blood-glucose homeostasis during fasting, and is also used as a source of energy for muscle contraction. PhK is one of the largest and most complex protein kinases, composed of a heterotetramer containing four molecules each of four subunit types: one catalytic (gamma) and three regulatory (alpha, beta, and delta). The gamma 2 subunit (PhKG2) is also referred to as the testis/liver gamma isoform. Mutations in its gene cause autosomal-recessive glycogenosis of the liver. The gamma subunit, when isolated, is constitutively active and does not require phosphorylation of the A-loop for activity. The regulatory subunits restrain this kinase activity until signals are received to relieve this inhibition. For example, the kinase is activated in response to hormonal stimulation, after autophosphorylation or phosphorylation by cAMP-dependent kinase of the alpha and beta subunits. The high-affinity binding of ADP to the beta subunit also stimulates kinase activity, whereas calcium relieves inhibition by binding to the delta (calmodulin) subunit. The PhKG2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271083 [Multi-domain]  Cd Length: 279  Bit Score: 106.21  E-value: 2.30e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  46 VNKVRVAIKKISPFEHQTYCQRTLREIKILLRFR-HENIIGINDiirapTIEQMKDVYIVQDLMET-DLYKLLKTQ-HLS 122
Cdd:cd14181  40 VKIIEVTAERLSPEQLEEVRSSTLKEIHILRQVSgHPSIITLID-----SYESSTFIFLVFDLMRRgELFDYLTEKvTLS 114
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 123 NDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDhtgfLTEYVATRWYRAPEIMLNS 202
Cdd:cd14181 115 EKETRSIMRSLLEAVSYLHANNIVHRDLKPENILLDDQLHIKLSDFGFSCHLEPGEK----LRELCGTPGYLAPEILKCS 190
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 203 -----KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG---ILGSPSQEDLNciinlkarnyllslphknkvp 274
Cdd:cd14181 191 mdethPGYGKEVDLWACGVILFTLLAGSPPFWHRRQMLMLRMIMEgryQFSSPEWDDRS--------------------- 249
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 66932916 275 wnrlfpnadSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14181 250 ---------STVKDLISRLLVVDPEIRLTAEQALQHPFF 279
STKc_DRAK cd14106
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
31-313 2.89e-26

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs, also called STK17, were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. They may play a role in apoptotic signaling. The DRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271008 [Multi-domain]  Cd Length: 268  Bit Score: 105.51  E-value: 2.89e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQR-TLREIKIL-LRFRHENIIGINDIIRAPTieqmkDVYIVQDLM 108
Cdd:cd14106  16 LGRGKFAVVRKCIHKETGKEYAAKFLRKRRRGQDCRNeILHEIAVLeLCKDCPRVVNLHEVYETRS-----ELILILELA 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT---CDLKICDFGLARVADPDHDhtgf 183
Cdd:cd14106  91 AGgELQTLLdEEECLTEADVRRLMRQILEGVQYLHERNIVHLDLKPQNILLTSEfplGDIKLCDFGISRVIGEGEE---- 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYRAPEImLNSKGYTKSIDIWSVGcILAEMLsnrpifpgkhyldqLNHILGILGSPSQEDLNCIINLKarny 263
Cdd:cd14106 167 IREILGTPDYVAPEI-LSYEPISLATDMWSIG-VLTYVL--------------LTGHSPFGGDDKQETFLNISQCN---- 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 264 lLSLPHKnkvpwnrLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14106 227 -LDFPEE-------LFKDVSPLAIDFIKRLLVKDPEKRLTAKECLEHPWL 268
STKc_TLK cd13990
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the ...
24-312 5.15e-26

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270892 [Multi-domain]  Cd Length: 279  Bit Score: 105.09  E-value: 5.15e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIK------KISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIrapTIEQ 97
Cdd:cd13990   1 RYLLLNLLGKGGFSEVYKAFDLVEQRYVACKihqlnkDWSEEKKQNYIKHALREYEIHKSLDHPRIVKLYDVF---EIDT 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  98 MKDVYIVQDLMETDLYKLLKTQHL--SNDHICyFLYQILRGLKYI--HSANVLHRDLKPSNLLL---NTTCDLKICDFGL 170
Cdd:cd13990  78 DSFCTVLEYCDGNDLDFYLKQHKSipEREARS-IIMQVVSALKYLneIKPPIIHYDLKPGNILLhsgNVSGEIKITDFGL 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 171 ARVADPDHDHTGFL---TEYVATRWYRAPEIMLNSKGYTK---SIDIWSVGCILAEMLSNRPIFPgkhyldqlnhilgiL 244
Cdd:cd13990 157 SKIMDDESYNSDGMeltSQGAGTYWYLPPECFVVGKTPPKissKVDVWSVGVIFYQMLYGRKPFG--------------H 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 245 GSPSQEDLNCIINLKARNylLSLPHKNKVpwnrlfpnaDSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd13990 223 NQSQEAILEENTILKATE--VEFPSKPVV---------SSEAKDFIRRCLTYRKEDRPDVLQLANDPY 279
STKc_PKA_like cd05580
Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs ...
31-228 6.20e-26

Catalytic subunit of the Serine/Threonine Kinases, cAMP-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the cAMP-dependent protein kinases, PKA and PRKX, and similar proteins. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. PRKX is also reulated by the R subunit and is is present in many tissues including fetal and adult brain, kidney, and lung. It is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PKA-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270732 [Multi-domain]  Cd Length: 290  Bit Score: 105.35  E-value: 6.20e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIK--KISPFEHQTYCQRTLREIKILLRFRHeniigindiiraPTIEQM-------KDV 101
Cdd:cd05580   9 LGTGSFGRVRLVKHKDSGKYYALKilKKAKIIKLKQVEHVLNEKRILSEVRH------------PFIVNLlgsfqddRNL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMET-DLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAdPDHD 179
Cdd:cd05580  77 YMVMEYVPGgELFSLLrRSGRFPNDVAKFYAAEVVLALEYLHSLDIVYRDLKPENLLLDSDGHIKITDFGFAKRV-KDRT 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 180 HTgflteYVATRWYRAPEIMLNsKGYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd05580 156 YT-----LCGTPEYLAPEIILS-KGHGKAVDWWALGILIYEMLAGYPPF 198
STKc_MEKK1_plant cd06632
Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP) ...
31-313 9.36e-26

Catalytic domain of the Serine/Threonine Kinase, Plant Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of plant MAPK kinase kinases (MAPKKKs) including Arabidopsis thaliana MEKK1 and MAPKKK3. Arabidopsis thaliana MEKK1 activates MPK4, a MAPK that regulates systemic acquired resistance. MEKK1 also participates in the regulation of temperature-sensitive and tissue-specific cell death. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The plant MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270802 [Multi-domain]  Cd Length: 259  Bit Score: 104.02  E-value: 9.36e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKK---ISPFEHQTYCQRTL-REIKILLRFRHENIIgindiiRAPTIEQMKD-VYIVQ 105
Cdd:cd06632   8 LGSGSFGSVYEGFNGDTGDFFAVKEvslVDDDKKSRESVKQLeQEIALLSKLRHPNIV------QYYGTEREEDnLYIFL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMET-DLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAdpdhDHTGF 183
Cdd:cd06632  82 EYVPGgSIHKLLQRyGAFEEPVIRLYTRQILSGLAYLHSRNTVHRDIKGANILVDTNGVVKLADFGMAKHV----EAFSF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYRAPE-IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkHYLDQLNHILGILGSPsqedlnciinlkarn 262
Cdd:cd06632 158 AKSFKGSPYWMAPEvIMQKNSGYGLAVDIWSLGCTVLEMATGKPPW---SQYEGVAAIFKIGNSG--------------- 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 263 yllSLPhknKVPwNRLFPnadsKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06632 220 ---ELP---PIP-DHLSP----DAKDFIRLCLQRDPEDRPTASQLLEHPFV 259
STKc_CASK cd14094
Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein ...
61-313 1.20e-25

Catalytic domain of the Serine/Threonine Kinase, Calcium/calmodulin-dependent serine protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CASK belongs to the MAGUK (membrane-associated guanylate kinase) protein family, which functions as multiple domain adaptor proteins and is characterized by the presence of a core of three domains: PDZ, SH3, and guanylate kinase (GuK). The enzymatically inactive GuK domain in MAGUK proteins mediates protein-protein interactions and associates intramolecularly with the SH3 domain. In addition, CASK contains a catalytic kinase and two L27 domains. It is highly expressed in the nervous system and plays roles in synaptic protein targeting, neural development, and regulation of gene expression. Binding partners include parkin (a Parkinson's disease molecule), neurexin (adhesion molecule), syndecans, calcium channel proteins, CINAP (nucleosome assembly protein), transcription factor Tbr-1, and the cytoplasmic adaptor proteins Mint1, Veli/mLIN-7/MALS, SAP97, caskin, and CIP98. Deletion or mutations in the CASK gene have been implicated in X-linked mental retardation. The CASK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270996 [Multi-domain]  Cd Length: 300  Bit Score: 104.55  E-value: 1.20e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  61 HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQM-KDVYIVQdLMET---DLYKLLKTQHLSNDHICY-------- 128
Cdd:cd14094  24 HRETGQQFAVKIVDVAKFTSSPGLSTEDLKREASICHMlKHPHIVE-LLETyssDGMLYMVFEFMDGADLCFeivkrada 102
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 129 -FLY----------QILRGLKYIHSANVLHRDLKPSNLLL---NTTCDLKICDFGLARvadpDHDHTGFLTE-YVATRWY 193
Cdd:cd14094 103 gFVYseavashymrQILEALRYCHDNNIIHRDVKPHCVLLaskENSAPVKLGGFGVAI----QLGESGLVAGgRVGTPHF 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 194 RAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGkhyldqlnhilgilgspSQEDLNCIInlkarnyllslpHKNKV 273
Cdd:cd14094 179 MAPEV-VKREPYGKPVDVWGCGVILFILLSGCLPFYG-----------------TKERLFEGI------------IKGKY 228
                       250       260       270       280
                ....*....|....*....|....*....|....*....|.
gi 66932916 274 PWN-RLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14094 229 KMNpRQWSHISESAKDLVRRMLMLDPAERITVYEALNHPWI 269
STKc_MSK1_C cd14179
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
31-324 1.33e-25

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271081 [Multi-domain]  Cd Length: 310  Bit Score: 104.74  E-value: 1.33e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISP-FEHQTycQRTLREIKilLRFRHENIIGINDIIRaptiEQMKDVYIVQDLME 109
Cdd:cd14179  15 LGEGSFSICRKCLHKKTNQEYAVKIVSKrMEANT--QREIAALK--LCEGHPNIVKLHEVYH----DQLHTFLVMELLKG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL---NTTCDLKICDFGLARVADPDHDhtgFLT 185
Cdd:cd14179  87 GELLeRIKKKQHFSETEASHIMRKLVSAVSHMHDVGVVHRDLKPENLLFtdeSDNSEIKIIDFGFARLKPPDNQ---PLK 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 EYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCiinlkarnyll 265
Cdd:cd14179 164 TPCFTLHYAAPEL-LNYNGYDESCDLWSLGVILYTMLSGQVPFQCHDKSLTCTSAEEIMKKIKQGDFSF----------- 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 266 slphkNKVPWNrlfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPI 324
Cdd:cd14179 232 -----EGEAWK----NVSQEAKDLIQGLLTVDPNKRIKMSGLRYNEWLQDGSQLSSNPL 281
STKc_TSSK6-like cd14164
Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs ...
25-313 2.22e-25

Catalytic domain of testis-specific serine/threonine kinase 6 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK6, also called SSTK, is expressed at the head of elongated sperm. It can phosphorylate histones and associate with heat shock protens HSP90 and HSC70. Male mice deficient in TSSK6 are infertile, showing spermatogenic impairment including reduced sperm counts, impaired DNA condensation, abnormal morphology and decreased motility rates. The TSSK6-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271066 [Multi-domain]  Cd Length: 256  Bit Score: 103.02  E-value: 2.22e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-----SPfehqTYCQRTL-REIKILLRFRHENIIGINDIIRAPTieqm 98
Cdd:cd14164   2 YTLGTTIGEGSFSKVKLATSQKYCCKVAIKIVdrrraSP----DFVQKFLpRELSILRRVNHPNIVQMFECIEVAN---- 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLMETDLYKLLKTQHlsndHICY-----FLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD-LKICDFGLAR 172
Cdd:cd14164  74 GRLYIVMEAAATDLLQKIQEVH----HIPKdlardMFAQMVGAVNYLHDMNIVHRDLKCENILLSADDRkIKIADFGFAR 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 VAdpdHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSnrpifpgkhyldqlnhilGILgsPSQEDL 252
Cdd:cd14164 150 FV---EDYPELSTTFCGSRAYTPPEVILGTPYDPKKYDVWSLGVVLYVMVT------------------GTM--PFDETN 206
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 253 NCIINLKAR--NYL--LSLPHKNKVpwnrlfpnadskaldLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14164 207 VRRLRLQQRgvLYPsgVALEEPCRA---------------LIRTLLQFNPSTRPSIQQVAGNSWL 256
STKc_myosinIII_N_like cd06608
N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze ...
31-313 2.73e-25

N-terminal Catalytic domain of Class III myosin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class III myosins are motor proteins with an N-terminal kinase catalytic domain and a C-terminal actin-binding motor domain. Class III myosins are present in the photoreceptors of invertebrates and vertebrates and in the auditory hair cells of mammals. The kinase domain of myosin III can phosphorylate several cytoskeletal proteins, conventional myosin regulatory light chains, and can autophosphorylate the C-terminal motor domain. Myosin III may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. It may also function as a cargo carrier during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The Drosophila class III myosin, called NinaC (Neither inactivation nor afterpotential protein C), is critical in normal adaptation and termination of photoresponse. Vertebrates contain two isoforms of class III myosin, IIIA and IIIB. This subfamily also includes mammalian NIK-like embryo-specific kinase (NESK), Traf2- and Nck-interacting kinase (TNIK), and mitogen-activated protein kinase (MAPK) kinase kinase kinase 4/6. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The class III myosin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270785 [Multi-domain]  Cd Length: 275  Bit Score: 103.15  E-value: 2.73e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTycQRTLREIKILLRF-RHENIIGIND--IIRAPTIEQmKDVYIVQDL 107
Cdd:cd06608  14 IGEGTYGKVYKARHKKTGQLAAIKIMDIIEDEE--EEIKLEINILRKFsNHPNIATFYGafIKKDPPGGD-DQLWLVMEY 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 ME----TDLYK--LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARvadpDHDHT 181
Cdd:cd06608  91 CGggsvTDLVKglRKKGKRLKEEWIAYILRETLRGLAYLHENKVIHRDIKGQNILLTEEAEVKLVDFGVSA----QLDST 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 -GFLTEYVATRWYRAPEIMLNSKGYTKSI----DIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsqedlncii 256
Cdd:cd06608 167 lGRRNTFIGTPYWMAPEVIACDQQPDASYdarcDVWSLGITAIELADGKPPLCDMHPMRALFKIP--------------- 231
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 257 nlkaRNYLLSLPHKNKvpWNRLFPnadskalDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06608 232 ----RNPPPTLKSPEK--WSKEFN-------DFISECLIKNYEQRPFTEELLEHPFI 275
STKc_CAMKK cd14118
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; ...
31-312 3.15e-25

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). Vertebrates contain two CaMKKs, CaMKK1 (or alpha) and CaMKK2 (or beta). CaMKK1 is involved in the regulation of glucose uptake in skeletal muscles. CaMKK2 is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. The CaMKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271020 [Multi-domain]  Cd Length: 275  Bit Score: 102.82  E-value: 3.15e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIS---------------PFEHQTYC-------QRTLREIKILLRFRHENIIGIND 88
Cdd:cd14118   2 IGKGSYGIVKLAYNEEDNTLYAMKILSkkkllkqagffrrppPRRKPGALgkpldplDRVYREIAILKKLDHPNVVKLVE 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  89 IIRAPTIEQMkdvYIVQDLMET-DLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICD 167
Cdd:cd14118  82 VLDDPNEDNL---YMVFELVDKgAVMEVPTDNPLSEETARSYFRDIVLGIEYLHYQKIIHRDIKPSNLLLGDDGHVKIAD 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 168 FGlarVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYT--KSIDIWSVGCILAEMLSNRPIFpgkhyldQLNHILGIlg 245
Cdd:cd14118 159 FG---VSNEFEGDDALLSSTAGTPAFMAPEALSESRKKFsgKALDIWAMGVTLYCFVFGRCPF-------EDDHILGL-- 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 246 spsQEdlnciinlKARNYLLSLPHKnkvpwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14118 227 ---HE--------KIKTDPVVFPDD---------PVVSEQLKDLILRMLDKNPSERITLPEIKEHPW 273
STKc_CaMKI_beta cd14169
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
31-313 3.23e-25

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271071 [Multi-domain]  Cd Length: 277  Bit Score: 103.05  E-value: 3.23e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISpfehqtycQRTLR--------EIKILLRFRHENIIGINDIIRAPTieqmkDVY 102
Cdd:cd14169  11 LGEGAFSEVVLAQERGSQRLVALKCIP--------KKALRgkeamvenEIAVLRRINHENIVSLEDIYESPT-----HLY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFGLARVADpd 177
Cdd:cd14169  78 LAMELVTGGelFDRIIERGSYTEKDASQLIGQVLQAVKYLHQLGIVHRDLKPENLLYATPFEdskIMISDFGLSKIEA-- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 hdhTGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqedlnciin 257
Cdd:cd14169 156 ---QGMLSTACGTPGYVAPEL-LEQKPYGKAVDVWAIGVISYILLCGYPPFYDENDSELFNQI----------------- 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 258 LKArNYLLSLPHknkvpWNRLfpnADSkALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14169 215 LKA-EYEFDSPY-----WDDI---SES-AKDFIRHLLERDPEKRFTCEQALQHPWI 260
STKc_CaMKI_gamma cd14166
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
31-313 3.50e-25

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I gamma; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271068 [Multi-domain]  Cd Length: 285  Bit Score: 103.15  E-value: 3.50e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIK--KISPFEHQTYCQRtlrEIKILLRFRHENIIGINDIIRAPTieqmkDVYIVQDLM 108
Cdd:cd14166  11 LGSGAFSEVYLVKQRSTGKLYALKciKKSPLSRDSSLEN---EIAVLKRIKHENIVTLEDIYESTT-----HYYLVMQLV 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT---TCDLKICDFGLARVADpdhdhTGF 183
Cdd:cd14166  83 SGgELFdRILERGVYTEKDASRVINQVLSAVKYLHENGIVHRDLKPENLLYLTpdeNSKIMITDFGLSKMEQ-----NGI 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhYldqlnhilgilgspSQEDLNCIINLKARNY 263
Cdd:cd14166 158 MSTACGTPGYVAPEV-LAQKPYSKAVDCWSIGVITYILLCGYPPF----Y--------------EETESRLFEKIKEGYY 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 264 LLSLPHknkvpWNRLfpnADSkALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14166 219 EFESPF-----WDDI---SES-AKDFIRHLLEKNPSKRYTCEKALSHPWI 259
STKc_CaMKI cd14083
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
31-312 4.40e-25

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270985 [Multi-domain]  Cd Length: 259  Bit Score: 102.06  E-value: 4.40e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISpfehqtycQRTLR--------EIKILLRFRHENIIGINDIIRAPTieqmkDVY 102
Cdd:cd14083  11 LGTGAFSEVVLAEDKATGKLVAIKCID--------KKALKgkedslenEIAVLRKIKHPNIVQLLDIYESKS-----HLY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDL----------METDLYKLLKTQHLsndhicyfLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFG 169
Cdd:cd14083  78 LVMELvtggelfdriVEKGSYTEKDASHL--------IRQVLEAVDYLHSLGIVHRDLKPENLLYYSPDEdskIMISDFG 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 170 LARVADPdhdhtGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhYldqlnhilgilgspSQ 249
Cdd:cd14083 150 LSKMEDS-----GVMSTACGTPGYVAPEV-LAQKPYGKAVDCWSIGVISYILLCGYPPF----Y--------------DE 205
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 250 EDLNCIINLKARNYLLSLPHknkvpWNRLfpnADSkALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14083 206 NDSKLFAQILKAEYEFDSPY-----WDDI---SDS-AKDFIRHLMEKDPNKRYTCEQALEHPW 259
STKc_Kin4 cd14076
Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the ...
22-313 4.91e-25

Catalytic domain of the yeast Serine/Threonine Kinase, Kin4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kin4 is a central component of the spindle position checkpoint (SPOC), which monitors spindle position and regulates the mitotic exit network (MEN). Kin4 associates with spindle pole bodies in mother cells to inhibit MEN signaling and delay mitosis until the anaphase nucleus is properly positioned along the mother-bud axis. Kin4 activity is regulated by both the bud neck-associated kinase Elm1 and protein phosphatase 2A. The Kin4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270978 [Multi-domain]  Cd Length: 270  Bit Score: 102.18  E-value: 4.91e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  22 GPrYTNLSYIGEGAYGMV-----CSAYDNVNKVRVAIKKISPFEHQTYCQ--RTLREIKILLRFRHENIIGINDIIrapt 94
Cdd:cd14076   1 GP-YILGRTLGEGEFGKVklgwpLPKANHRSGVQVAIKLIRRDTQQENCQtsKIMREINILKGLTHPNIVRLLDVL---- 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  95 iEQMKDVYIVQDLMET-DLYK-LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR 172
Cdd:cd14076  76 -KTKKYIGIVLEFVSGgELFDyILARRRLKDSVACRLFAQLISGVAYLHKKGVVHRDLKLENLLLDKNRNLVITDFGFAN 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 VAdpDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKS-IDIWSVGCILAEMLSNRPIFPGKHYldqlnhilgilgSPSQED 251
Cdd:cd14076 155 TF--DHFNGDLMSTSCGSPCYAAPELVVSDSMYAGRkADIWSCGVILYAMLAGYLPFDDDPH------------NPNGDN 220
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 252 LNciinlKARNYLLSLPHKnkvpwnrlFPN-ADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14076 221 VP-----RLYRYICNTPLI--------FPEyVTPKARDLLRRILVPNPRKRIRLSAIMRHAWL 270
STKc_MEKK1 cd06630
Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP) ...
31-226 5.77e-25

Catalytic domain of the Protein Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK1 is a MAPK kinase kinase (MAPKKK or MKKK) that phosphorylates and activates activates the ERK1/2 and c-Jun N-terminal kinase (JNK) pathways by activating their respective MAPKKs, MEK1/2 and MKK4/MKK7, respectively. MEKK1 is important in regulating cell survival and apoptosis. MEKK1 also plays a role in cell migration, tissue maintenance and homeostasis, and wound healing. The MEKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270800 [Multi-domain]  Cd Length: 268  Bit Score: 102.12  E-value: 5.77e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIS-----PFEHQTYCQRTLREIKILLRFRHENIIgindiiRAPTIEQMKDVY-IV 104
Cdd:cd06630   8 LGTGAFSSCYQARDVKTGTLMAVKQVSfcrnsSSEQEEVVEAIREEIRMMARLNHPNIV------RMLGATQHKSHFnIF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETDLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTC-DLKICDFGLA-RVADpdhDH 180
Cdd:cd06630  82 VEWMAGGSVASLLSKYgaFSENVIINYTLQILRGLAYLHDNQIIHRDLKGANLLVDSTGqRLRIADFGAAaRLAS---KG 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 181 TG---FLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRP 226
Cdd:cd06630 159 TGageFQGQLLGTIAFMAPEV-LRGEQYGRSCDVWSVGCVIIEMATAKP 206
STKc_PSKH1 cd14087
Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the ...
24-313 8.33e-25

Catalytic domain of the Protein Serine/Threonine kinase H1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PSKH1 is an autophosphorylating STK that is expressed ubiquitously and exhibits multiple intracellular localizations including the centrosome, Golgi apparatus, and splice factor compartments. It contains a catalytic kinase domain and an N-terminal SH4-like motif that is acylated to facilitate membrane attachment. PSKH1 plays a rile in the maintenance of the Golgi apparatus, an important organelle within the secretory pathway. It may also function as a novel splice factor and a regulator of prostate cancer cell growth. The PSKH1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270989 [Multi-domain]  Cd Length: 259  Bit Score: 101.46  E-value: 8.33e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRtlrEIKILLRFRHENIIGINDIIraptiEQMKDVY 102
Cdd:cd14087   2 KYDIKALIGRGSFSRVVRVEHRVTRQPYAIKMIeTKCRGREVCES---ELNVLRRVRHTNIIQLIEVF-----ETKERVY 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMET-DLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL---NTTCDLKICDFGLARVADPD 177
Cdd:cd14087  74 MVMELATGgELFdRIIAKGSFTERDATRVLQMVLDGVKYLHGLGITHRDLKPENLLYyhpGPDSKIMITDFGLASTRKKG 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HDHtgFLTEYVATRWYRAPEIMLNsKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEdlnciin 257
Cdd:cd14087 154 PNC--LMKTTCGTPEYIAPEILLR-KPYTQSVDMWAVGVIAYILLSGTMPFDDDNRTRLYRQILRAKYSYSGE------- 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 258 lkarnyllslphknkvPWnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14087 224 ----------------PW----PSVSNLAKDFIDRLLTVNPGERLSATQALKHPWI 259
STKc_Nek4 cd08223
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
24-313 1.13e-24

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek4 is highly abundant in the testis. Its specific function is unknown. Neks are involved in the regulation of downstream processes following the activation of Cdc2, and many of their functions are cell cycle-related. They play critical roles in microtubule dynamics during ciliogenesis and mitosis. Nek4 is one in a family of 11 different Neks (Nek1-11). The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270862 [Multi-domain]  Cd Length: 257  Bit Score: 100.97  E-value: 1.13e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIspfEHQTYCQRTLR----EIKILLRFRHENIIGINDIIraptieQMK 99
Cdd:cd08223   1 EYQFLRVIGKGSYGEVWLVRHKRDRKQYVIKKL---NLKNASKRERKaaeqEAKLLSKLKHPNIVSYKESF------EGE 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 D--VYIVQDLMET-DLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV 173
Cdd:cd08223  72 DgfLYIVMGFCEGgDLYTRLKEQKgvlLEERQVVEWFVQIAMALQYMHERNILHRDLKTQNIFLTKSNIIKVGDLGIARV 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 ADPDHDhtgFLTEYVATRWYRAPEIMLNsKGYTKSIDIWSVGCILAEMLSNRPIFpgkhyldqlnhilgilgspsqedln 253
Cdd:cd08223 152 LESSSD---MATTLIGTPYYMSPELFSN-KPYNHKSDVWALGCCVYEMATLKHAF------------------------- 202
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 254 ciiNLKARNYLLSLPHKNKVPwnrLFPNADSKAL-DLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd08223 203 ---NAKDMNSLVYKILEGKLP---PMPKQYSPELgELIKAMLHQDPEKRPSVKRILRQPYI 257
STKc_NUAK cd14073
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze ...
24-313 1.25e-24

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK1, also called ARK5 (AMPK-related protein kinase 5), regulates cell proliferation and displays tumor suppression through direct interaction and phosphorylation of p53. It is also involved in cell senescence and motility. High NUAK1 expression is associated with invasiveness of nonsmall cell lung cancer (NSCLC) and breast cancer cells. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. The NUAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270975 [Multi-domain]  Cd Length: 254  Bit Score: 100.93  E-value: 1.25e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI--SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRaptiEQMKDV 101
Cdd:cd14073   2 RYELLETLGKGTYGKVKLAIERATGREVAIKSIkkDKIEDEQDMVRIRREIEIMSSLNHPHIIRIYEVFE----NKDKIV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMETDLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHdh 180
Cdd:cd14073  78 IVMEYASGGELYDYIsERRRLPEREARRIFRQIVSAVHYCHKNGVVHRDLKLENILLDQNGNAKIADFGLSNLYSKDK-- 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 tgFLTEYVATRWYRAPEImLNSKGYT-KSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspSQedlnciinlk 259
Cdd:cd14073 156 --LLQTFCGSPLYASPEI-VNGTPYQgPEVDCWSLGVLLYTLVYGTMPFDGSDFKRLVKQI-------SS---------- 215
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 260 ARNYLlslphknkvpwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14073 216 GDYRE---------------PTQPSDASGLIRWMLTVNPKRRATIEDIANHWWV 254
STKc_DCKL cd14095
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called ...
31-312 1.33e-24

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase (also called Doublecortin-like and CAM kinase-like); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL (or DCAMKL) proteins belong to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL proteins contain a C-terminal kinase domain with similarity to CAMKs. They are involved in the regulation of cAMP signaling. Vertebrates contain three DCKL proteins (DCKL1-3); DCKL1 and 2 also contain a serine, threonine, and proline rich domain (SP), while DCKL3 contains only a single DCX domain instead of tandem domains. The DCKL subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270997 [Multi-domain]  Cd Length: 258  Bit Score: 100.86  E-value: 1.33e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISpfehqtycQRTLR--------EIKILLRFRHENIIGINDIIRAPTieqmkDVY 102
Cdd:cd14095   8 IGDGNFAVVKECRDKATDKEYALKIID--------KAKCKgkehmienEVAILRRVKHPNIVQLIEEYDTDT-----ELY 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMET-DLYKLLK--TQHLSNDHICYFlYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD----LKICDFGLARVAd 175
Cdd:cd14095  75 LVMELVKGgDLFDAITssTKFTERDASRMV-TDLAQALKYLHSLSIVHRDIKPENLLVVEHEDgsksLKLADFGLATEV- 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 pdhdhTGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPgkhyldqlnhilgilgSP--SQEDLN 253
Cdd:cd14095 153 -----KEPLFTVCGTPTYVAPEI-LAETGYGLKVDIWAAGVITYILLCGFPPFR----------------SPdrDQEELF 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 254 CIInLKARNYLLSlPHknkvpWNrlfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14095 211 DLI-LAGEFEFLS-PY-----WD----NISDSAKDLISRMLVVDPEKRYSAGQVLDHPW 258
STKc_Nek10 cd08528
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
25-252 1.35e-24

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 10; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. No function has yet been ascribed to Nek10. The gene encoding Nek10 is a putative causative gene for breast cancer; it is located within a breast cancer susceptibility loci on chromosome 3p24. Nek10 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270867 [Multi-domain]  Cd Length: 270  Bit Score: 101.04  E-value: 1.35e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRV-AIKKI---SPFEHQTYCQR------TLREIKILL-RFRHENIIGINDiirap 93
Cdd:cd08528   2 YAVLELLGSGAFGCVYKVRKKSNGQTLlALKEInmtNPAFGRTEQERdksvgdIISEVNIIKeQLRHPNIVRYYK----- 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  94 TIEQMKDVYIVQDLME----TDLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSAN-VLHRDLKPSNLLLNTTCDLKIC 166
Cdd:cd08528  77 TFLENDRLYIVMELIEgaplGEHFSSLKEKneHFTEDRIWNIFVQMVLALRYLHKEKqIVHRDLKPNNIMLGEDDKVTIT 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 167 DFGLARVADPDhdhTGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGS 246
Cdd:cd08528 157 DFGLAKQKGPE---SSKMTSVVGTILYSCPEI-VQNEPYGEKADIWALGCILYQMCTLQPPFYSTNMLTLATKIVEAEYE 232

                ....*.
gi 66932916 247 PSQEDL 252
Cdd:cd08528 233 PLPEGM 238
STKc_Rim15_like cd05611
Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the ...
97-312 1.52e-24

Catalytic domain of fungal Rim15-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include Saccharomyces cerevisiae Rim15, Schizosaccharomyces pombe cek1, and similar fungal proteins. They contain a central catalytic domain, which contains an insert relative to MAST kinases. In addition, Rim15 contains a C-terminal signal receiver (REC) domain while cek1 contains an N-terminal PAS domain. Rim15 (or Rim15p) functions as a regulator of meiosis. It acts as a downstream effector of PKA and regulates entry into stationary phase (G0). Thus, it plays a crucial role in regulating yeast proliferation, differentiation, and aging. Cek1 may facilitate progression of mitotic anaphase. The Rim15-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270762 [Multi-domain]  Cd Length: 263  Bit Score: 100.63  E-value: 1.52e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 QMKD-VYIVQD-LMETDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV 173
Cdd:cd05611  67 QSKDyLYLVMEyLNGGDCASLIKTLgGLPEDWAKQYIAEVVLGVEDLHQRGIIHRDIKPENLLIDQTGHLKLTDFGLSRN 146
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 ADPDHDHTGFlteyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGkhyldqlnhilgilGSPSQEDLN 253
Cdd:cd05611 147 GLEKRHNKKF----VGTPDYLAPET-ILGVGDDKMSDWWSLGCVIFEFLFGYPPFHA--------------ETPDAVFDN 207
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 254 CIinlkarnyllslphKNKVPW-NRLFPNADSKALDLLDKMLTFNPHKRIE---VEQALAHPY 312
Cdd:cd05611 208 IL--------------SRRINWpEEVKEFCSPEAVDLINRLLCMDPAKRLGangYQEIKSHPF 256
STKc_Byr2_like cd06628
Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein ...
29-313 1.83e-24

Catalytic domain of the Serine/Threonine Kinases, fungal Byr2-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Schizosaccharomyces pombe Byr2, Saccharomyces cerevisiae and Cryptococcus neoformans Ste11, and related proteins. They contain an N-terminal SAM (sterile alpha-motif) domain, which mediates protein-protein interaction, and a C-terminal catalytic domain. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Fission yeast Byr2 is regulated by Ras1. It responds to pheromone signaling and controls mating through the MAPK pathway. Budding yeast Ste11 functions in MAPK cascades that regulate mating, high osmolarity glycerol, and filamentous growth responses. The Byr2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270798 [Multi-domain]  Cd Length: 267  Bit Score: 100.69  E-value: 1.83e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  29 SYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTL-------REIKILLRFRHENIIGINDIIRAPTIEQMKD 100
Cdd:cd06628   6 ALIGSGSFGSVYLGMNASSGELMAVKQVElPSVSAENKDRKKsmldalqREIALLRELQHENIVQYLGSSSDANHLNIFL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYI----VQDLMetDLYKLLKTQHLSNdhicyFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADP 176
Cdd:cd06628  86 EYVpggsVATLL--NNYGAFEESLVRN-----FVRQILKGLNYLHNRGIIHRDIKGANILVDNKGGIKISDFGISKKLEA 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 DHDHTGFLTEYVATR---WYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGkhyLDQLNHI--LGILGSPSqed 251
Cdd:cd06628 159 NSLSTKNNGARPSLQgsvFWMAPEVVKQTS-YTRKADIWSLGCLVVEMLTGTHPFPD---CTQMQAIfkIGENASPT--- 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916 252 lnciinlkarnyllslphknkVPwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06628 232 ---------------------IP-----SNISSEARDFLEKTFEIDHNKRPTADELLKHPFL 267
STKc_DCKL2 cd14184
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called ...
31-312 1.87e-24

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 2 (also called Doublecortin-like and CAM kinase-like 2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL2 (or DCAMKL2) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL2 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL2 has been shown to interact with tubulin, JIP1/2, JNK, neurabin 2, and actin. It is associated with the terminal segments of axons and dendrites, and may function as a phosphorylation-dependent switch to control microtubule dynamics in neuronal growth cones. The DCKL2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271086 [Multi-domain]  Cd Length: 259  Bit Score: 100.49  E-value: 1.87e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTieqmkDVYIVQDLMET 110
Cdd:cd14184   9 IGDGNFAVVKECVERSTGKEFALKIIDKAKCCGKEHLIENEVSILRRVKHPNIIMLIEEMDTPA-----ELYLVMELVKG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 -DLYKLL--KTQHLSNDHiCYFLYQILRGLKYIHSANVLHRDLKPSNLLL----NTTCDLKICDFGLARVADpdhdhtGF 183
Cdd:cd14184  84 gDLFDAItsSTKYTERDA-SAMVYNLASALKYLHGLCIVHRDIKPENLLVceypDGTKSLKLGDFGLATVVE------GP 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYRAPEIMLNSkGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL--DQLNHIL-GILGSPSqedlnciinlka 260
Cdd:cd14184 157 LYTVCGTPTYVAPEIIAET-GYGLKVDIWAAGVITYILLCGFPPFRSENNLqeDLFDQILlGKLEFPS------------ 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 261 rnyllslPHknkvpWNrlfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14184 224 -------PY-----WD----NITDSAKELISHMLQVNVEARYTAEQILSHPW 259
STKc_YSK4 cd06631
Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs ...
31-313 2.57e-24

Catalytic domain of the Serine/Threonine Kinase, Yeast Sps1/Ste20-related Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. YSK4 is a putative MAPKKK, whose mammalian gene has been isolated. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The YSK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270801 [Multi-domain]  Cd Length: 266  Bit Score: 100.20  E-value: 2.57e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVrVAIKKI-----SPFEHQTYCQRTLREIKILLRFRHENIIGIndiiraptIEQMKDVYIVQ 105
Cdd:cd06631   9 LGKGAYGTVYCGLTSTGQL-IAVKQVeldtsDKEKAEKEYEKLQEEVDLLKTLKHVNIVGY--------LGTCLEDNVVS 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLME----TDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR---VADPD 177
Cdd:cd06631  80 IFMEfvpgGSIASILARfGALEEPVFCRYTKQILEGVAYLHNNNVIHRDIKGNNIMLMPNGVIKLIDFGCAKrlcINLSS 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HDHTGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPifPGKHyLDQLNHILGIlGSpsqedlnciin 257
Cdd:cd06631 160 GSQSQLLKSMRGTPYWMAPEV-INETGHGRKSDIWSIGCTVFEMATGKP--PWAD-MNPMAAIFAI-GS----------- 223
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 258 lkarnyllslpHKNKVPwnRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06631 224 -----------GRKPVP--RLPDKFSPEARDFVHACLTRDQDERPSAEQLLKHPFI 266
STKc_MEKK3_like_u1 cd06653
Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP) ...
31-312 3.55e-24

Catalytic domain of an Uncharacterized subfamily of Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized proteins with similarity to MEKK3, MEKK2, and related proteins; they contain an N-terminal PB1 domain, which mediates oligomerization, and a C-terminal catalytic domain. MEKK2 and MEKK3 are MAPK kinase kinases (MAPKKKs or MKKKs), proteins that phosphorylate and activate MAPK kinases (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MEKK2 and MEKK3 activate MEK5 (also called MKK5), which activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. MEKK2 and MEKK3 can also activate the MAPKs, c-Jun N-terminal kinase (JNK) and p38, through their respective MAPKKs. The MEKK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270819 [Multi-domain]  Cd Length: 264  Bit Score: 99.71  E-value: 3.55e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIsPFEHQtyCQRTLRE-------IKILLRFRHENIIGINDIIRAPtiEQMKDVYI 103
Cdd:cd06653  10 LGRGAFGEVYLCYDADTGRELAVKQV-PFDPD--SQETSKEvnaleceIQLLKNLRHDRIVQYYGCLRDP--EEKKLSIF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLKTQHLSNDHICY-FLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-RVADPDHDHT 181
Cdd:cd06653  85 VEYMPGGSVKDQLKAYGALTENVTRrYTRQILQGVSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASkRIQTICMSGT 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GfLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPifPGKHYlDQLNHILGILGSPSQEdlnciinlkar 261
Cdd:cd06653 165 G-IKSVTGTPYWMSPEV-ISGEGYGRKADVWSVACTVVEMLTEKP--PWAEY-EAMAAIFKIATQPTKP----------- 228
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 262 nyllslphknkvpwnRLFPNADSKALDLLdKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd06653 229 ---------------QLPDGVSDACRDFL-RQIFVEEKRRPTAEFLLRHPF 263
STKc_SPEG_rpt2 cd14111
Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle ...
25-313 3.86e-24

Catalytic kinase domain, second repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271013 [Multi-domain]  Cd Length: 257  Bit Score: 99.51  E-value: 3.86e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKvRVAIKKISPFEHQTYcQRTLREIKILLRFRHENIIGINDIIRAPTIEqmkdVYIV 104
Cdd:cd14111   5 YTFLDEKARGRFGVIRRCRENATG-KNFPAKIVPYQAEEK-QGVLQEYEILKSLHHERIMALHEAYITPRYL----VLIA 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETD-LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgf 183
Cdd:cd14111  79 EFCSGKElLHSLIDRFRYSEDDVVGYLVQILQGLEYLHGRRVLHLDIKPDNIMVTNLNAIKIVDFGSAQSFNPLSLRQ-- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQedlnciinlkarny 263
Cdd:cd14111 157 LGRRTGTLEYMAPE-MVKGEPVGPPADIWSIGVLTYIMLSGRSPFEDQDPQETEAKILVAKFDAFK-------------- 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 264 llslphknkvpwnrLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14111 222 --------------LYPNVSQSASLFLKKVLSSYPWSRPTTKDCFAHAWL 257
STKc_ULK2 cd14201
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the ...
25-314 3.87e-24

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK2 is ubiquitously expressed and is essential in autophagy induction. It displays partially redundant functions with ULK1 and is able to compensate for the loss of ULK1 in non-selective autophagy. It also displays neuron-specific functions and is important in axon development. The ULK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271103 [Multi-domain]  Cd Length: 271  Bit Score: 100.08  E-value: 3.87e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSA-YDNVNKVRVAIKKISPfEHQTYCQRTL-REIKILLRFRHENIIGINDIIRAPTieqmkDVY 102
Cdd:cd14201   8 YSRKDLVGHGAFAVVFKGrHRKKTDWEVAIKSINK-KNLSKSQILLgKEIKILKELQHENIVALYDVQEMPN-----SVF 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMET-DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN---------TTCDLKICDFGLA 171
Cdd:cd14201  82 LVMEYCNGgDLADYLQAKgTLSEDTIRVFLQQIAAAMRILHSKGIIHRDLKPQNILLSyasrkkssvSGIRIKIADFGFA 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 172 RvadpdHDHTGFLTEYV-ATRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhyldQLNhilgilgspSQE 250
Cdd:cd14201 162 R-----YLQSNMMAATLcGSPMYMAPEVIM-SQHYDAKADLWSIGTVIYQCLVGKPPF-------QAN---------SPQ 219
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916 251 DLNCIINlKARNYLLSLPHKNKvPWNRlfpnadskalDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd14201 220 DLRMFYE-KNKNLQPSIPRETS-PYLA----------DLLLGLLQRNQKDRMDFEAFFSHPFLE 271
PKc_MAPKK cd06605
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase ...
27-316 4.24e-24

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein Kinase Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MAPKKs are dual-specificity PKs that phosphorylate their downstream targets, MAPKs, at specific threonine and tyrosine residues. The MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The pathways involve a triple kinase core cascade comprising the MAPK, which is phosphorylated and activated by a MAPK kinase (MAPKK or MKK or MAP2K), which itself is phosphorylated and activated by a MAPKK kinase (MAPKKK or MKKK or MAP3K). There are three MAPK subfamilies: extracellular signal-regulated kinase (ERK), c-Jun N-terminal kinase (JNK), and p38. In mammalian cells, there are seven MAPKKs (named MKK1-7) and 20 MAPKKKs. Each MAPK subfamily can be activated by at least two cognate MAPKKs and by multiple MAPKKKs. The MAPKK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270782 [Multi-domain]  Cd Length: 265  Bit Score: 99.73  E-value: 4.24e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  27 NLSYIGEGAYGmvcsaydNVNKVR-------VAIKKISPFEHQTYCQRTLREIKILLRFRHENIIG-----INDiirapt 94
Cdd:cd06605   5 YLGELGEGNGG-------VVSKVRhrpsgqiMAVKVIRLEIDEALQKQILRELDVLHKCNSPYIVGfygafYSE------ 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  95 ieqmKDVYIVQDLME-TDLYKLLKTQHLSNDHICYFL-YQILRGLKYIHSA-NVLHRDLKPSNLLLNTTCDLKICDFGLa 171
Cdd:cd06605  72 ----GDISICMEYMDgGSLDKILKEVGRIPERILGKIaVAVVKGLIYLHEKhKIIHRDVKPSNILVNSRGQVKLCDFGV- 146
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 172 rvadpdhdhTGFLTE-----YVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPgkhylDQLNHILGILg 245
Cdd:cd06605 147 ---------SGQLVDslaktFVGTRSYMAPE-RISGGKYTVKSDIWSLGLSLVELATGRfPYPP-----PNAKPSMMIF- 210
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 246 spsqEDLNCIINLKARnyllSLPhknkvpwNRLFPnadSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQY 316
Cdd:cd06605 211 ----ELLSYIVDEPPP----LLP-------SGKFS---PDFQDFVSQCLQKDPTERPSYKELMEHPFIKRY 263
STKc_ULK1 cd14202
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the ...
31-314 4.42e-24

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. ULK1 is required for efficient amino acid starvation-induced autophagy and mitochondrial clearance. It associates with three autophagy-related proteins (Atg13, FIP200 amd Atg101) to form the ULK1 complex. All fours proteins are essential for autophagosome formation. ULK1 is regulated by both mammalian target-of rapamycin complex 1 (mTORC1) and AMP-activated protein kinase (AMPK). mTORC1 negatively regulates the ULK1 complex in a nutrient-dependent manner while AMPK stimulates autophagy by inhibiting mTORC1. ULK1 also plays neuron-specific roles and is involved in non-clathrin-coated endocytosis in growth cones, filopodia extension, neurite extension, and axon branching. The ULK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271104 [Multi-domain]  Cd Length: 267  Bit Score: 99.70  E-value: 4.42e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSA-YDNVNKVRVAIKKISPfEHQTYCQRTL-REIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLM 108
Cdd:cd14202  10 IGHGAFAVVFKGrHKEKHDLEVAVKCINK-KNLAKSQTLLgKEIKILKELKHENIVALYDFQ-----EIANSVYLVMEYC 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL----------NTTCdLKICDFGLARVADP 176
Cdd:cd14202  84 NGgDLADYLHTMRtLSEDTIRLFLQQIAGAMKMLHSKGIIHRDLKPQNILLsysggrksnpNNIR-IKIADFGFARYLQN 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 DHdhtgFLTEYVATRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPIFPgkhyldqlnhilgilgSPSQEDLNCII 256
Cdd:cd14202 163 NM----MAATLCGSPMYMAPEVIM-SQHYDAKADLWSIGTIIYQCLTGKAPFQ----------------ASSPQDLRLFY 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 257 NlKARNYLLSLPHKNKVPWNRLFpnadskaLDLLDKmltfNPHKRIEVEQALAHPYLE 314
Cdd:cd14202 222 E-KNKSLSPNIPRETSSHLRQLL-------LGLLQR----NQKDRMDFDEFFHHPFLD 267
STKc_DAPK1 cd14194
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs ...
70-313 4.76e-24

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. It is Ca2+/calmodulin (CaM)-regulated and actin-associated protein that contains an N-terminal kinase domain followed by an autoinhibitory CaM binding region and a large C-terminal extension with multiple functional domains including ankyrin (ANK) repeats, a cytoskeletal binding domain, a Death domain, and a serine-rich tail. Loss of DAPK1 expression, usually because of DNA methylation, is implicated in many tumor types. DAPK1 is highly abundant in the brain and has also been associated with neurodegeneration. The DAPK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271096 [Multi-domain]  Cd Length: 269  Bit Score: 99.71  E-value: 4.76e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  70 REIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLMET-DLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLH 147
Cdd:cd14194  57 REVSILKEIQHPNVITLHEVY-----ENKTDVILILELVAGgELFDFLaEKESLTEEEATEFLKQILNGVYYLHSLQIAH 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 148 RDLKPSN-LLLNTTCD---LKICDFGLARVADPDHDHTGFLteyvATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd14194 132 FDLKPENiMLLDRNVPkprIKIIDFGLAHKIDFGNEFKNIF----GTPEFVAPEI-VNYEPLGLEADMWSIGVITYILLS 206
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 224 NRPIFpgkhyldqlnhilgiLGSPSQEDLnciINLKARNYLLSlphknkvpwNRLFPNADSKALDLLDKMLTFNPHKRIE 303
Cdd:cd14194 207 GASPF---------------LGDTKQETL---ANVSAVNYEFE---------DEYFSNTSALAKDFIRRLLVKDPKKRMT 259
                       250
                ....*....|
gi 66932916 304 VEQALAHPYL 313
Cdd:cd14194 260 IQDSLQHPWI 269
STKc_Nek3 cd08219
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
24-228 5.37e-24

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek3 is primarily localized in the cytoplasm and shows no cell cycle-dependent changes in its activity. It is present in the axons of neurons and affects morphogenesis and polarity through its regulation of microtubule acetylation. Nek3 modulates the signaling of the prolactin receptor through its activation of Vav2 and contributes to prolactin-mediated motility of breast cancer cells. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173759 [Multi-domain]  Cd Length: 255  Bit Score: 99.28  E-value: 5.37e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDiirapTIEQMKDVYI 103
Cdd:cd08219   1 QYNVLRVVGEGSFGRALLVQHVNSDQKYAMKEIRLPKSSSAVEDSRKEAVLLAKMKHPNIVAFKE-----SFEADGHLYI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMET-DLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV-ADPdh 178
Cdd:cd08219  76 VMEYCDGgDLMQKIKLQRgklFPEDTILQWFVQMCLGVQHIHEKRVLHRDIKSKNIFLTQNGKVKLGDFGSARLlTSP-- 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 dhTGFLTEYVATRWYRAPEIMLNSKGYTKSiDIWSVGCILAEMLSNRPIF 228
Cdd:cd08219 154 --GAYACTYVGTPYYVPPEIWENMPYNNKS-DIWSLGCILYELCTLKHPF 200
STKc_SLK_like cd06611
Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the ...
31-318 5.84e-24

Catalytic domain of Ste20-Like Kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the subfamily include SLK, STK10 (also called LOK for Lymphocyte-Oriented Kinase), SmSLK (Schistosoma mansoni SLK), and related proteins. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It also plays a role in mediating actin reorganization. STK10 is responsible in regulating the CD28 responsive element in T cells, as well as leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. SmSLK is capable of activating the MAPK Jun N-terminal kinase (JNK) pathway in human embryonic kidney cells as well as in Xenopus oocytes. It may participate in regulating MAPK cascades during host-parasite interactions. The SLK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132942 [Multi-domain]  Cd Length: 280  Bit Score: 99.43  E-value: 5.84e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYCQRTLREIKILLRFRHENIIGINDiirAPTIEQMKDVYI------- 103
Cdd:cd06611  13 LGDGAFGKVYKAQHKETGLFAAAKIIQ-IESEEELEDFMVEIDILSECKHPNIVGLYE---AYFYENKLWILIefcdgga 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMetdlyklLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGL-ARVADPDHDHT 181
Cdd:cd06611  89 LDSIM-------LELERgLTEPQIRYVCRQMLEALNFLHSHKVIHRDLKAGNILLTLDGDVKLADFGVsAKNKSTLQKRD 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFlteyVATRWYRAPEIML----NSKGYTKSIDIWSVGCILAEMLSNRPifPgKHYLDQLNHILGILGSPSQEdlnciin 257
Cdd:cd06611 162 TF----IGTPYWMAPEVVAcetfKDNPYDYKADIWSLGITLIELAQMEP--P-HHELNPMRVLLKILKSEPPT------- 227
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 258 lkarnylLSLPHKnkvpWNRLFPnadskalDLLDKMLTFNPHKRIEVEQALAHPYLEQYYD 318
Cdd:cd06611 228 -------LDQPSK----WSSSFN-------DFLKSCLVKDPDDRPTAAELLKHPFVSDQSD 270
STKc_Bck1_like cd06629
Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein ...
124-313 6.54e-24

Catalytic domain of the Serine/Threonine Kinases, fungal Bck1-like Mitogen-Activated Protein Kinase Kinase Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include the MAPKKKs Saccharomyces cerevisiae Bck1 and Schizosaccharomyces pombe Mkh1, and related proteins. Budding yeast Bck1 is part of the cell integrity MAPK pathway, which is activated by stresses and aggressions to the cell wall. The MAPKKK Bck1, MAPKKs Mkk1 and Mkk2, and the MAPK Slt2 make up the cascade that is important in the maintenance of cell wall homeostasis. Fission yeast Mkh1 is involved in MAPK cascades regulating cell morphology, cell wall integrity, salt resistance, and filamentous growth in response to stress. MAPKKKs phosphorylate and activate MAPK kinases, which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The Bck1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270799 [Multi-domain]  Cd Length: 270  Bit Score: 99.38  E-value: 6.54e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 124 DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYrAPE-IMLNS 202
Cdd:cd06629 108 DLVRFFTRQILDGLAYLHSKGILHRDLKADNILVDLEGICKISDFGISKKSDDIYGNNGATSMQGSVFWM-APEvIHSQG 186
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 203 KGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLdQLNHILGILGS--PSQEDLNciinlkarnylLSlphknkvpwnrlfp 280
Cdd:cd06629 187 QGYSAKVDIWSLGCVVLEMLAGRRPWSDDEAI-AAMFKLGNKRSapPVPEDVN-----------LS-------------- 240
                       170       180       190
                ....*....|....*....|....*....|...
gi 66932916 281 nadSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06629 241 ---PEALDFLNACFAIDPRDRPTAAELLSHPFL 270
STKc_NUAK2 cd14161
Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs ...
24-233 1.15e-23

Catalytic domain of the Serine/Threonine Kinase, novel (nua) kinase family NUAK 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NUAK proteins are classified as AMP-activated protein kinase (AMPK)-related kinases, which like AMPK are activated by the major tumor suppressor LKB1. Vertebrates contain two NUAK proteins, called NUAK1 and NUAK2. NUAK2, also called SNARK (Sucrose, non-fermenting 1/AMP-activated protein kinase-related kinase), is involved in energy metabolism. It is activated by hyperosmotic stress, DNA damage, and nutrients such as glucose and glutamine. NUAK2-knockout mice develop obesity, altered serum lipid profiles, hyperinsulinaemia, hyperglycaemia, and impaired glucose tolerance. NUAK2 is implicated in regulating actin stress fiber assembly through its association with myosin phosphatase Rho-interacting protein (MRIP), which leads to an increase in myosin regulatory light chain (MLC) phosphorylation. It is also associated with tumor growth, migration, and oncogenicity of melanoma cells. The NUAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271063 [Multi-domain]  Cd Length: 255  Bit Score: 98.10  E-value: 1.15e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVrVAIKKI--SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDV 101
Cdd:cd14161   4 RYEFLETLGKGTYGRVKKARDSSGRL-VAIKSIrkDRIKDEQDLLHIRREIEIMSSLNHPHIISVYEVF-----ENSSKI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLM-ETDLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHd 179
Cdd:cd14161  78 VIVMEYAsRGDLYDYIsERQRLSELEARHFFRQIVSAVHYCHANGIVHRDLKLENILLDANGNIKIADFGLSNLYNQDK- 156
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 180 htgFLTEYVATRWYRAPEImLNSKGYT-KSIDIWSVGCILAEMLSNRPIFPGKHY 233
Cdd:cd14161 157 ---FLQTYCGSPLYASPEI-VNGRPYIgPEVDSWSLGVLLYILVHGTMPFDGHDY 207
STKc_MSK_C cd14092
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
68-323 1.60e-23

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270994 [Multi-domain]  Cd Length: 311  Bit Score: 98.91  E-value: 1.60e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  68 TLREIKIL-LRFRHENIIGINDIIRAPTieqmkDVYIVQDLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSAN 144
Cdd:cd14092  45 TSREVQLLrLCQGHPNIVKLHEVFQDEL-----HTYLVMELLRGGelLERIRKKKRFTESEASRIMRQLVSAVSFMHSKG 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 145 VLHRDLKPSNLLL---NTTCDLKICDFGLARVadpdHDHTGFLTEYVATRWYRAPEIMLNSK---GYTKSIDIWSVGCIL 218
Cdd:cd14092 120 VVHRDLKPENLLFtdeDDDAEIKIVDFGFARL----KPENQPLKTPCFTLPYAAPEVLKQALstqGYDESCDLWSLGVIL 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 219 AEMLSNRPIFPGKHYldqlnhilgilGSPSQEDLNCIinlKARNYLLSLPHknkvpWNrlfpNADSKALDLLDKMLTFNP 298
Cdd:cd14092 196 YTMLSGQVPFQSPSR-----------NESAAEIMKRI---KSGDFSFDGEE-----WK----NVSSEAKSLIQGLLTVDP 252
                       250       260
                ....*....|....*....|....*
gi 66932916 299 HKRIEVEQALAHPYLEQYYDPSDEP 323
Cdd:cd14092 253 SKRLTMSELRNHPWLQGSSSPSSTP 277
STKc_TAK1 cd14058
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated ...
31-228 1.92e-23

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Activated Kinase-1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAK1 is also known as mitogen-activated protein kinase kinase kinase 7 (MAPKKK7 or MAP3K7), TAK, or MEKK7. As a MAPKKK, it is an important mediator of cellular responses to extracellular signals. It regulates both the c-Jun N-terminal kinase and p38 MAPK cascades by activating the MAPK kinases, MKK4 and MKK3/6. In addition, TAK1 plays diverse roles in immunity and development, in different biological contexts, through many signaling pathways including TGFbeta/BMP, Wnt/Fz, and NF-kB. It is also implicated in the activation of the tumor suppressor kinase, LKB1. The TAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270960 [Multi-domain]  Cd Length: 253  Bit Score: 97.51  E-value: 1.92e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSA-YDNVNkvrVAIKKIspfEHQTYCQRTLREIKILLRFRHENIIGINDIirapTIEQMKDVYIVQDLME 109
Cdd:cd14058   1 VGRGSFGVVCKArWRNQI---VAVKII---ESESEKKAFEVEVRQLSRVDHPNIIKLYGA----CSNQKPVCLVMEYAEG 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKTQ----HLSNDHICYFLYQILRGLKYIHSAN---VLHRDLKPSNLLL-NTTCDLKICDFGLArvadpdHDHT 181
Cdd:cd14058  71 GSLYNVLHGKepkpIYTAAHAMSWALQCAKGVAYLHSMKpkaLIHRDLKPPNLLLtNGGTVLKICDFGTA------CDIS 144
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 182 GFLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd14058 145 THMTNNKGSAAWMAPEVFEGSK-YSEKCDVFSWGIILWEVITRRKPF 190
STKc_DAPK cd14105
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs ...
70-313 2.06e-23

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK1 is the prototypical member of the subfamily and is also simply referred to as DAPK. DAPK2 is also called DAPK-related protein 1 (DRP-1), while DAPK3 has also been named DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk). These proteins are ubiquitously expressed in adult tissues, are capable of cross talk with each other, and may act synergistically in regulating cell death. The DAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271007 [Multi-domain]  Cd Length: 269  Bit Score: 97.94  E-value: 2.06e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  70 REIKILLRFRHENIIGINDIIRAPTieqmkDVYIVQDLMET-DLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLH 147
Cdd:cd14105  57 REVSILRQVLHPNIITLHDVFENKT-----DVVLILELVAGgELFDFLaEKESLSEEEATEFLKQILDGVNYLHTKNIAH 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 148 RDLKPSNLLLNTTC----DLKICDFGLARVADPDHDHTGFLteyvATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd14105 132 FDLKPENIMLLDKNvpipRIKLIDFGLAHKIEDGNEFKNIF----GTPEFVAPEI-VNYEPLGLEADMWSIGVITYILLS 206
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 224 NRPIFpgkhyldqlnhilgiLGSPSQEDLNciiNLKARNYLLSlphknkvpwNRLFPNADSKALDLLDKMLTFNPHKRIE 303
Cdd:cd14105 207 GASPF---------------LGDTKQETLA---NITAVNYDFD---------DEYFSNTSELAKDFIRQLLVKDPRKRMT 259
                       250
                ....*....|
gi 66932916 304 VEQALAHPYL 313
Cdd:cd14105 260 IQESLRHPWI 269
STKc_MAP4K3_like cd06613
Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like ...
25-312 2.09e-23

Catalytic domain of Mitogen-activated protein kinase kinase kinase kinase (MAP4K) 3-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes MAP4K3, MAP4K1, MAP4K2, MAP4K5, and related proteins. Vertebrate members contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K1, also called haematopoietic progenitor kinase 1 (HPK1), is a hematopoietic-specific STK involved in many cellular signaling cascades including MAPK, antigen receptor, apoptosis, growth factor, and cytokine signaling. It participates in the regulation of T cell receptor signaling and T cell-mediated immune responses. MAP4K2 was referred to as germinal center (GC) kinase because of its preferred location in GC B cells. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. It is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). The MAP4K3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270788 [Multi-domain]  Cd Length: 259  Bit Score: 97.38  E-value: 2.09e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIK--KISPFEHQTYCQRtlrEIKILLRFRHENIIGINDiirapTIEQMKDVY 102
Cdd:cd06613   2 YELIQRIGSGTYGDVYKARNIATGELAAVKviKLEPGDDFEIIQQ---EISMLKECRHPNIVAYFG-----SYLRRDKLW 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVqdlME-------TDLYKllKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAd 175
Cdd:cd06613  74 IV---MEycgggslQDIYQ--VTGPLSELQIAYVCRETLKGLAYLHSTGKIHRDIKGANILLTEDGDVKLADFGVSAQL- 147
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 pdhDHT-GFLTEYVATRWYRAPEIMLNSK--GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLnHILGILGSPSqedl 252
Cdd:cd06613 148 ---TATiAKRKSFIGTPYWMAPEVAAVERkgGYDGKCDIWALGITAIELAELQPPMFDLHPMRAL-FLIPKSNFDP---- 219
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 253 nciinlkarnyllslPH-KNKVPWNRLFpnadskaLDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd06613 220 ---------------PKlKDKEKWSPDF-------HDFIKKCLTKNPKKRPTATKLLQHPF 258
STKc_TAO3 cd06633
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze ...
25-240 2.80e-23

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO3 is also known as JIK (c-Jun N-terminal kinase inhibitory kinase) or KFC (kinase from chicken). It specifically activates JNK, presumably by phosphorylating and activating MKK4/MKK7. In Saccharomyces cerevisiae, TAO3 is a component of the RAM (regulation of Ace2p activity and cellular morphogenesis) signaling pathway. TAO3 is upregulated in retinal ganglion cells after axotomy, and may play a role in apoptosis. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270803 [Multi-domain]  Cd Length: 313  Bit Score: 98.57  E-value: 2.80e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTY--CQRTLREIKILLRFRHENIIgindiiraptieQMKDVY 102
Cdd:cd06633  23 FVDLHEIGHGSFGAVYFATNSHTNEVVAIKKMSYSGKQTNekWQDIIKEVKFLQQLKHPNTI------------EYKGCY 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQD----LME------TDLYKLLKtQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR 172
Cdd:cd06633  91 LKDHtawlVMEyclgsaSDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSAS 169
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 VADPDHdhtgfltEYVATRWYRAPEIML--NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 240
Cdd:cd06633 170 IASPAN-------SFVGTPYWMAPEVILamDEGQYDGKVDIWSLGITCIELAERKPPLFNMNAMSALYHI 232
PKc_CLK3 cd14214
Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3; Dual-specificity ...
24-313 2.86e-23

Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 3; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. CLK3 is predominantly expressed in mature spermatozoa, and might play a role in the fertilization process. CLKs are involved in the phosphorylation and regulation of serine/arginine-rich (SR) proteins, which play a crucial role in pre-mRNA splicing by directing splice site selection. SR proteins are phosphorylated first by SR protein kinases (SRPKs) at the N-terminus, which leads to its assembly into nuclear speckles where splicing factors are stored. CLKs phosphorylate the C-terminal part of SR proteins, causing the nuclear speckles to dissolve and splicing factors to be recruited at sites of active transcription. Based on a conserved "EHLAMMERILG" signature motif which may be crucial for substrate specificity, CLKs are also referred to as LAMMER kinases. CLKs autophosphorylate at tyrosine residues and phosphorylate their substrates exclusively on serine/threonine residues. The CLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271116 [Multi-domain]  Cd Length: 331  Bit Score: 98.54  E-value: 2.86e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNV-NKVRVAIKKISPFehQTYCQRTLREIKILLRFRHENIIGINDIIraptieQMKD-- 100
Cdd:cd14214  14 RYEIVGDLGEGTFGKVVECLDHArGKSQVALKIIRNV--GKYREAARLEINVLKKIKEKDKENKFLCV------LMSDwf 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 -----VYIVQDLMETDLYKLLKTQHLSN---DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL-----------NTTC 161
Cdd:cd14214  86 nfhghMCIAFELLGKNTFEFLKENNFQPyplPHIRHMAYQLCHALKFLHENQLTHTDLKPENILFvnsefdtlyneSKSC 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 162 D--------LKICDFGLARVadpDHDHTgflTEYVATRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHY 233
Cdd:cd14214 166 EeksvkntsIRVADFGSATF---DHEHH---TTIVATRHYRPPEVIL-ELGWAQPCDVWSLGCILFEYYRGFTLFQTHEN 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 234 LDQLNHILGILGS-PSQedlnCIINLKARNYLlslpHKNKVPWN----------------RLFPNADS----KALDLLDK 292
Cdd:cd14214 239 REHLVMMEKILGPiPSH----MIHRTRKQKYF----YKGSLVWDenssdgryvsenckplMSYMLGDSlehtQLFDLLRR 310
                       330       340
                ....*....|....*....|.
gi 66932916 293 MLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14214 311 MLEFDPALRITLKEALLHPFF 331
STKc_CaMKIV cd14085
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
25-313 3.89e-23

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type IV; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. There are several types of CaMKs including CaMKI, CaMKII, and CaMKIV. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKIV is found predominantly in neurons and immune cells. It is activated by the binding of calcium/CaM and phosphorylation by CaMKK (alpha or beta). The CaMKK-CaMKIV cascade participates in regulating several transcription factors like CREB, MEF2, and retinoid orphan receptors. It also is implicated in T-cell development and signaling, cytokine secretion, and signaling through Toll-like receptors, and is thus, pivotal in immune response and inflammation. The CaMKIV subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270987 [Multi-domain]  Cd Length: 294  Bit Score: 97.59  E-value: 3.89e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpfehQTYCQRTLR-EIKILLRFRHENIIGINDIIRAPTieqmkDVYI 103
Cdd:cd14085   5 FEIESELGRGATSVVYRCRQKGTQKPYAVKKLK----KTVDKKIVRtEIGVLLRLSHPNIIKLKEIFETPT-----EISL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMET-DLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFGLARVAdpdh 178
Cdd:cd14085  76 VLELVTGgELFdRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPdapLKIADFGLSKIV---- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 DHTGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhYLDQLNHILgilgspSQEDLNCiinl 258
Cdd:cd14085 152 DQQVTMKTVCGTPGYCAPEI-LRGCAYGPEVDMWSVGVITYILLCGFEPF----YDERGDQYM------FKRILNC---- 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 259 kaRNYLLSlphknkvPWnrlFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14085 217 --DYDFVS-------PW---WDDVSLNAKDLVKKLIVLDPKKRLTTQQALQHPWV 259
STKc_PAK_II cd06648
Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze ...
23-313 4.05e-23

Catalytic domain of the Serine/Threonine Kinase, Group II p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group II PAKs, also called non-conventional PAKs, include PAK4, PAK5, and PAK6. Group II PAKs contain PBD (p21-binding domain) and catalytic domains, but lack other motifs found in group I PAKs, such as an AID (autoinhibitory domain) and SH3 binding sites. Since group II PAKs do not contain an obvious AID, they may be regulated differently from group I PAKs. While group I PAKs interact with the SH3 containing proteins Nck, Grb2 and PIX, no such binding has been demonstrated for group II PAKs. Some known substrates of group II PAKs are also substrates of group I PAKs such as Raf, BAD, LIMK and GEFH1. Unique group II substrates include MARK/Par-1 and PDZ-RhoGEF. Group II PAKs play important roles in filopodia formation, neuron extension, cytoskeletal organization, and cell survival. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270815 [Multi-domain]  Cd Length: 261  Bit Score: 96.74  E-value: 4.05e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  23 PRY--TNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQtycQRTL--REIKILLRFRHENIIgindiiraptieQM 98
Cdd:cd06648   5 PRSdlDNFVKIGEGSTGIVCIATDKSTGRQVAVKKMDLRKQQ---RRELlfNEVVIMRDYQHPNIV------------EM 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQD----LME----TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGL 170
Cdd:cd06648  70 YSSYLVGDelwvVMEflegGALTDIVTHTRMNEEQIATVCRAVLKALSFLHSQGVIHRDIKSDSILLTSDGRVKLSDFGF 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 171 ARVADPDHDHTGFLteyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqe 250
Cdd:cd06648 150 CAQVSKEVPRRKSL---VGTPYWMAPEV-ISRLPYGTEVDIWSLGIMVIEMVDGEPPYFNEPPLQAMKRI---------- 215
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 251 dlnciinlkarnyllslpHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06648 216 ------------------RDNEPPKLKNLHKVSPRLRSFLDRMLVRDPAQRATAAELLNHPFL 260
STKc_DCKL3 cd14185
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called ...
71-312 4.33e-23

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 3 (also called Doublecortin-like and CAM kinase-like 3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL3 (or DCAMKL3) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. DCKL3 contains a single DCX domain (instead of a tandem) and a C-terminal kinase domain with similarity to CAMKs. It has been shown to interact with tubulin and JIP1/2. The DCKL3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271087 [Multi-domain]  Cd Length: 258  Bit Score: 96.56  E-value: 4.33e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  71 EIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLMET-DLYK-LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHR 148
Cdd:cd14185  48 EILIIKSLSHPNIVKLFEVY-----ETEKEIYLILEYVRGgDLFDaIIESVKFTEHDAALMIIDLCEALVYIHSKHIVHR 122
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 149 DLKPSNLLLNTTCD----LKICDFGLARVAdpdhdhTGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSN 224
Cdd:cd14185 123 DLKPENLLVQHNPDksttLKLADFGLAKYV------TGPIFTVCGTPTYVAPEI-LSEKGYGLEVDMWAAGVILYILLCG 195
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 225 RPIFPgkhyldqlnhilgilgSP--SQEDLNCIINLKARNYLlsLPHknkvpWNrlfpNADSKALDLLDKMLTFNPHKRI 302
Cdd:cd14185 196 FPPFR----------------SPerDQEELFQIIQLGHYEFL--PPY-----WD----NISEAAKDLISRLLVVDPEKRY 248
                       250
                ....*....|
gi 66932916 303 EVEQALAHPY 312
Cdd:cd14185 249 TAKQVLQHPW 258
STKc_ULK4 cd14010
Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the ...
31-312 4.49e-23

Catalytic domain of the Serine/Threonine kinase, Unc-51-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ULK4 is a functionally uncharacterized kinase that shows similarity to ATG1/ULKs. The ATG1/ULK complex is conserved from yeast to humans and it plays a critical role in the initiation of autophagy, the intracellular system that leads to the lysosomal degradation of cellular components and their recycling into basic metabolic units. The ULK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270912 [Multi-domain]  Cd Length: 269  Bit Score: 96.98  E-value: 4.49e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVcsaYdnvnKVR-------VAIKKI--SPFEHQTYCQRTLREIKillrfrHENIIGINDiirapTIEQMKDV 101
Cdd:cd14010   8 IGRGKHSVV---Y----KGRrkgtiefVAIKCVdkSKRPEVLNEVRLTHELK------HPNVLKFYE-----WYETSNHL 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDL-METDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV------ 173
Cdd:cd14010  70 WLVVEYcTGGDLETLLRQdGNLPESSVRKFGRDLVRGLHYIHSKGIIYCDLKPSNILLDGNGTLKLSDFGLARRegeilk 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 -------ADPDHDHTGFLTEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPgkhyldqlnhilgilgS 246
Cdd:cd14010 150 elfgqfsDEGNVNKVSKKQAKRGTPYYMAPE-LFQGGVHSFASDLWALGCVLYEMFTGKPPFV----------------A 212
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 247 PSQEDLnciinlkARNYLlslphkNKVPwNRLFPNADSKA----LDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14010 213 ESFTEL-------VEKIL------NEDP-PPPPPKVSSKPspdfKSLLKGLLEKDPAKRLSWDELVKHPF 268
PKc_MKK3_6 cd06617
Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase ...
31-315 5.22e-23

Catalytic domain of the dual-specificity Protein Kinases, Mitogen-activated protein Kinase Kinases 3 and 6; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK3 and MKK6 are dual-specificity PKs that phosphorylate and activate their downstream target, p38 MAPK, on specific threonine and tyrosine residues. MKK3/6 play roles in the regulation of cell cycle progression, cytokine- and stress-induced apoptosis, oncogenic transformation, and adult tissue regeneration. In addition, MKK6 plays a critical role in osteoclast survival in inflammatory disease while MKK3 is associated with tumor invasion, progression, and poor patient survival in glioma. The MKK3/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173729 [Multi-domain]  Cd Length: 283  Bit Score: 97.11  E-value: 5.22e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVcsaydnvNKVR-------VAIKKISPFEHQTYCQRTLREIKILLRFRHeniigindiirAP-TIE------ 96
Cdd:cd06617   9 LGRGAYGVV-------DKMRhvptgtiMAVKRIRATVNSQEQKRLLMDLDISMRSVD-----------CPyTVTfygalf 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 QMKDVYIVQDLMETDLYKLLKT-----QHLSNDHICYFLYQILRGLKYIHSA-NVLHRDLKPSNLLLNTTCDLKICDFGL 170
Cdd:cd06617  71 REGDVWICMEVMDTSLDKFYKKvydkgLTIPEDILGKIAVSIVKALEYLHSKlSVIHRDVKPSNVLINRNGQVKLCDFGI 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 171 arvadpdhdhTGFLTEYVA------TRWYRAPEIM---LNSKGYTKSIDIWSVGCILAEMLSNRpiFPGKHYLDQLNHIL 241
Cdd:cd06617 151 ----------SGYLVDSVAktidagCKPYMAPERInpeLNQKGYDVKSDVWSLGITMIELATGR--FPYDSWKTPFQQLK 218
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916 242 GILGSPSQedlnciinlkarnyllslphknKVPWNRLFPNADskalDLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
Cdd:cd06617 219 QVVEEPSP----------------------QLPAEKFSPEFQ----DFVNKCLKKNYKERPNYPELLQHPFFEL 266
STKc_PLK4 cd14186
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the ...
25-313 6.23e-23

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK4, also called SAK or STK18, is structurally different from other PLKs in that it contains only one polo box that can form two adjacent polo boxes and a functional PDB by homodimerization. It is required for late mitotic progression, cell survival, and embryonic development. It localizes to centrosomes and is required for centriole duplication and chromosomal stability. Overexpression of PLK4 may be associated with colon tumors. The PLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271088 [Multi-domain]  Cd Length: 256  Bit Score: 96.08  E-value: 6.23e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQT--YCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVY 102
Cdd:cd14186   3 FKVLNLLGKGSFACVYRARSLHTGLEVAIKMIDKKAMQKagMVQRVRNEVEIHCQLKHPSILELYNYF-----EDSNYVY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLM---ETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-RVADPDH 178
Cdd:cd14186  78 LVLEMChngEMSRYLKNRKKPFTEDEARHFMHQIVTGMLYLHSHGILHRDLTLSNLLLTRNMNIKIADFGLAtQLKMPHE 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 DHTGFlteyVATRWYRAPEIMLNSKGYTKSiDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgsPSQEDLNCIINL 258
Cdd:cd14186 158 KHFTM----CGTPNYISPEIATRSAHGLES-DVWSLGCMFYTLLVGRPPFDTDTVKNTLNKVV-----LADYEMPAFLSR 227
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 259 KARnyllslphknkvpwnrlfpnadskalDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14186 228 EAQ--------------------------DLIHQLLRKNPADRLSLSSVLDHPFM 256
PKc_Wee1_like cd13997
Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the ...
24-311 7.31e-23

Catalytic domain of the Wee1-like Protein Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This subfamily is composed of the dual-specificity kinase Myt1, the protein tyrosine kinase Wee1, and similar proteins. These proteins are cell cycle checkpoint kinases that are involved in the regulation of cyclin-dependent kinase CDK1, the master engine for mitosis. CDK1 is kept inactivated through phosphorylation of N-terminal thr (T14 by Myt1) and tyr (Y15 by Myt1 and Wee1) residues. Mitosis progression is ensured through activation of CDK1 by dephoshorylation and inactivation of Myt1/Wee1. The Wee1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270899 [Multi-domain]  Cd Length: 252  Bit Score: 95.91  E-value: 7.31e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKK-ISPFEHQTYCQRTLREIKILLRF-RHENIIGINDiirapTIEQMKDV 101
Cdd:cd13997   1 HFHELEQIGSGSFSEVFKVRSKVDGCLYAVKKsKKPFRGPKERARALREVEAHAALgQHPNIVRYYS-----SWEEGGHL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLME----TDLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADp 176
Cdd:cd13997  76 YIQMELCEngslQDALEELsPISKLSEAEVWDLLLQVALGLAFIHSKGIVHLDIKPDNIFISNKGTCKIGDFGLATRLE- 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 dhdhTGFLTEYVATRwYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPiFPGKhyldqlnhilgilGSPSQEdlncii 256
Cdd:cd13997 155 ----TSGDVEEGDSR-YLAPELLNENYTHLPKADIFSLGVTVYEAATGEP-LPRN-------------GQQWQQ------ 209
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 257 nlkarnyllslPHKNKVPwnrLFPNAD-SKAL-DLLDKMLTFNPHKRIEVEQALAHP 311
Cdd:cd13997 210 -----------LRQGKLP---LPPGLVlSQELtRLLKVMLDPDPTRRPTADQLLAHD 252
STKc_PAK_I cd06647
Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze ...
24-314 9.03e-23

Catalytic domain of the Serine/Threonine Kinase, Group I p21-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Group I PAKs, also called conventional PAKs, include PAK1, PAK2, and PAK3. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). They interact with the SH3 domain containing proteins Nck, Grb2 and PIX. Binding of group I PAKs to activated GTPases leads to conformational changes that destabilize the AID, allowing autophosphorylation and full activation of the kinase domain. Known group I PAK substrates include MLCK, Bad, Raf, MEK1, LIMK, Merlin, Vimentin, Myc, Stat5a, and Aurora A, among others. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs are implicated in the regulation of many cellular processes including growth factor receptor-mediated proliferation, cell polarity, cell motility, cell death and survival, and actin cytoskeleton organization. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270814 [Multi-domain]  Cd Length: 261  Bit Score: 95.76  E-value: 9.03e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYCQRTLREIKILLRFRHENIIgindiiraptieQMKDVYI 103
Cdd:cd06647   8 KYTRFEKIGQGASGTVYTAIDVATGQEVAIKQMN-LQQQPKKELIINEILVMRENKNPNIV------------NYLDSYL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQD----LME----TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD 175
Cdd:cd06647  75 VGDelwvVMEylagGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFGFCAQIT 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 PDHDHTgflTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLnHILGILGSPsqedlnci 255
Cdd:cd06647 155 PEQSKR---STMVGTPYWMAPEV-VTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTP-------- 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 256 inlkarnyllSLPHKNKVpwNRLFPnadskalDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd06647 222 ----------ELQNPEKL--SAIFR-------DFLNRCLEMDVEKRGSAKELLQHPFLK 261
STKc_DAPK2 cd14196
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs ...
70-313 1.12e-22

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK2, also called DAPK-related protein 1 (DRP-1), is a Ca2+/calmodulin (CaM)-regulated protein containing an N-terminal kinase domain, a CaM autoinhibitory site and a dimerization module. It lacks the cytoskeletal binding regions of DAPK1 and the exogenous protein has been shown to be soluble and cytoplasmic. FLAG-tagged DAPK2, however, accumulated within membrane-enclosed autophagic vesicles. It is unclear where endogenous DAPK2 is localized. DAPK2 participates in TNF-alpha and FAS-receptor induced cell death and enhances neutrophilic maturation in myeloid leukemic cells. It contributes to the induction of anoikis and its down-regulation is implicated in the beta-catenin induced resistance of malignant epithelial cells to anoikis. The DAPK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271098 [Multi-domain]  Cd Length: 269  Bit Score: 95.79  E-value: 1.12e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  70 REIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLMET-DLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLH 147
Cdd:cd14196  57 REVSILRQVLHPNIITLHDVY-----ENRTDVVLILELVSGgELFDFLaQKESLSEEEATSFIKQILDGVNYLHTKKIAH 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 148 RDLKPSN-LLLNTTCDL---KICDFGLA-RVADPDHDHTGFLT-EYVatrwyrAPEImLNSKGYTKSIDIWSVGCILAEM 221
Cdd:cd14196 132 FDLKPENiMLLDKNIPIphiKLIDFGLAhEIEDGVEFKNIFGTpEFV------APEI-VNYEPLGLEADMWSIGVITYIL 204
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 222 LSNRPIFpgkhyldqlnhilgiLGSPSQEDLNciiNLKARNYLLSlphknkvpwNRLFPNADSKALDLLDKMLTFNPHKR 301
Cdd:cd14196 205 LSGASPF---------------LGDTKQETLA---NITAVSYDFD---------EEFFSHTSELAKDFIRKLLVKETRKR 257
                       250
                ....*....|..
gi 66932916 302 IEVEQALAHPYL 313
Cdd:cd14196 258 LTIQEALRHPWI 269
STKc_ROCK_NDR_like cd05573
Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear ...
31-314 1.27e-22

Catalytic domain of Rho-associated coiled-coil containing protein kinase (ROCK)- and Nuclear Dbf2-Related (NDR)-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily include ROCK and ROCK-like proteins such as DMPK, MRCK, and CRIK, as well as NDR and NDR-like proteins such as LATS, CBK1 and Sid2p. ROCK and CRIK are effectors of the small GTPase Rho, while MRCK is an effector of the small GTPase Cdc42. NDR and NDR-like kinases contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Proteins in this subfamily are involved in regulating many cellular functions including contraction, motility, division, proliferation, apoptosis, morphogenesis, and cytokinesis. The ROCK/NDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270725 [Multi-domain]  Cd Length: 350  Bit Score: 96.97  E-value: 1.27e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFE----HQTYCQRTLREIKIllrfrheniigindIIRAPTIEQMkdVYIVQD 106
Cdd:cd05573   9 IGRGAFGEVWLVRDKDTGQVYAMKILRKSDmlkrEQIAHVRAERDILA--------------DADSPWIVRL--HYAFQD 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 ------LME----TDLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA---- 171
Cdd:cd05573  73 edhlylVMEympgGDLMNLLiKYDVFPEETARFYIAELVLALDSLHKLGFIHRDIKPDNILLDADGHIKLADFGLCtkmn 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 172 ------RVADPDHDHTGFLTEYVATRW----------------YRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFp 229
Cdd:cd05573 153 ksgdreSYLNDSVNTLFQDNVLARRRPhkqrrvraysavgtpdYIAPEV-LRGTGYGPECDWWSLGVILYEMLYGFPPF- 230
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 230 gkhyldqlnhilgiLGSPSQEDLNCIINLKARnylLSLPHKNKVPwnrlfpnadSKALDLLDKMLTfNPHKRI-EVEQAL 308
Cdd:cd05573 231 --------------YSDSLVETYSKIMNWKES---LVFPDDPDVS---------PEAIDLIRRLLC-DPEDRLgSAEEIK 283

                ....*.
gi 66932916 309 AHPYLE 314
Cdd:cd05573 284 AHPFFK 289
STKc_CaMKK2 cd14199
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; ...
24-313 1.38e-22

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK2, also called CaMKK beta, is one of the most versatile CaMKs. It is involved in regulating energy balance, glucose metabolism, adiposity, hematopoiesis, inflammation, and cancer. CaMKK2 contains unique N- and C-terminal domains and a central catalytic kinase domain that is followed by a regulatory domain that bears overlapping autoinhibitory and CaM-binding regions. It can be activated by signaling through G-coupled receptors, IP3 receptors, plasma membrane ion channels, and Toll-like receptors. Thus, CaMKK2 acts as a molecular hub that is capable of receiving and decoding signals from diverse pathways. The CaMKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271101 [Multi-domain]  Cd Length: 286  Bit Score: 95.80  E-value: 1.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-------------------------PFEHQTYCQRTLREIKILLRF 78
Cdd:cd14199   3 QYKLKDEIGKGSYGVVKLAYNEDDNTYYAMKVLSkkklmrqagfprrppprgaraapegCTQPRGPIERVYQEIAILKKL 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  79 RHENIIGINDIIRAPTIEQMkdvYIVQDLMETD-LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL 157
Cdd:cd14199  83 DHPNVVKLVEVLDDPSEDHL---YMVFELVKQGpVMEVPTLKPLSEDQARFYFQDLIKGIEYLHYQKIIHRDVKPSNLLV 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 158 NTTCDLKICDFGlarVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGY--TKSIDIWSVGCILaemlsNRPIFPGKHYLD 235
Cdd:cd14199 160 GEDGHIKIADFG---VSNEFEGSDALLTNTVGTPAFMAPETLSETRKIfsGKALDVWAMGVTL-----YCFVFGQCPFMD 231
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 236 QlnHILGilgspsqedlnciINLKARNYLLSLPHKnkvpwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14199 232 E--RILS-------------LHSKIKTQPLEFPDQ---------PDISDDLKDLLFRMLDKNPESRISVPEIKLHPWV 285
STKc_DAPK3 cd14195
Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs ...
70-314 1.38e-22

Catalytic domain of the Serine/Threonine Kinase, Death-Associated Protein Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DAPKs mediate cell death and act as tumor suppressors. They are necessary to induce cell death and their overexpression leads to death-associated changes including membrane blebbing, cell rounding, and formation of autophagic vesicles. Vertebrates contain three subfamily members with different domain architecture, localization, and function. DAPK3, also called DAP-like kinase (DLK) and zipper-interacting protein kinase (ZIPk), contains an N-terminal kinase domain and a C-terminal region with nuclear localization signals (NLS) and a leucine zipper motif that mediates homodimerization and interaction with other leucine zipper proteins. It interacts with Par-4, a protein that contains a death domain and interacts with actin filaments. DAPK3 is present in both the cytoplasm and nucleus. Its co-expression with Par-4 results in the co-localization of the two proteins to actin filaments. In addition to cell death, DAPK3 is also implicated in mediating cell motility and the contraction of smooth muscles. The DAPK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271097 [Multi-domain]  Cd Length: 271  Bit Score: 95.46  E-value: 1.38e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  70 REIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLMET-DLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLH 147
Cdd:cd14195  57 REVNILREIQHPNIITLHDIF-----ENKTDVVLILELVSGgELFDFLaEKESLTEEEATQFLKQILDGVHYLHSKRIAH 131
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 148 RDLKPSNLLL----NTTCDLKICDFGLARVADPDHDHTGFLteyvATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd14195 132 FDLKPENIMLldknVPNPRIKLIDFGIAHKIEAGNEFKNIF----GTPEFVAPEI-VNYEPLGLEADMWSIGVITYILLS 206
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 224 NRPIFpgkhyldqlnhilgiLGSPSQEDLNciiNLKARNYLLSlphknkvpwNRLFPNADSKALDLLDKMLTFNPHKRIE 303
Cdd:cd14195 207 GASPF---------------LGETKQETLT---NISAVNYDFD---------EEYFSNTSELAKDFIRRLLVKDPKKRMT 259
                       250
                ....*....|.
gi 66932916 304 VEQALAHPYLE 314
Cdd:cd14195 260 IAQSLEHSWIK 270
STKc_TAO1 cd06635
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze ...
25-349 1.44e-22

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO1 is sometimes referred to as prostate-derived sterile 20-like kinase 2 (PSK2). TAO1 activates the p38 MAPK through direct interaction with and activation of MEK3. TAO1 is highly expressed in the brain and may play a role in neuronal apoptosis. TAO1 interacts with the checkpoint proteins BubR1 and Mad2, and plays an important role in regulating mitotic progression, which is required for both chromosome congression and checkpoint-induced anaphase delay. TAO1 may play a role in protecting genomic stability. TAO proteins possess MAPK kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270805 [Multi-domain]  Cd Length: 317  Bit Score: 96.66  E-value: 1.44e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQT--YCQRTLREIKILLRFRHENIIgindiiraptieQMKDVY 102
Cdd:cd06635  27 FSDLREIGHGSFGAVYFARDVRTSEVVAIKKMSYSGKQSneKWQDIIKEVKFLQRIKHPNSI------------EYKGCY 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQD----LME------TDLYKLLKtQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR 172
Cdd:cd06635  95 LREHtawlVMEyclgsaSDLLEVHK-KPLQEIEIAAITHGALQGLAYLHSHNMIHRDIKAGNILLTEPGQVKLADFGSAS 173
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 VADPDHdhtgfltEYVATRWYRAPEIML--NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqe 250
Cdd:cd06635 174 IASPAN-------SFVGTPYWMAPEVILamDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI---------- 236
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 251 dlnciinlkARNyllSLPHKNKVPWNRLFPNadskaldLLDKMLTFNPHKRIEVEQALAHPYLeQYYDPSDEPIAEAPFK 330
Cdd:cd06635 237 ---------AQN---ESPTLQSNEWSDYFRN-------FVDSCLQKIPQDRPTSEELLKHMFV-LRERPETVLIDLIQRT 296
                       330       340
                ....*....|....*....|.
gi 66932916 331 FDM--ELDDLPKEKLKELIFE 349
Cdd:cd06635 297 KDAvrELDNLQYRKMKKLLFQ 317
STKc_Nek8 cd08220
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
24-311 2.04e-22

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek8 contains an N-terminal kinase catalytic domain and a C-terminal RCC1 (regulator of chromosome condensation) domain. A double point mutation in Nek8 causes cystic kidney disease in mice that genetically resembles human autosomal recessive polycystic kidney disease (ARPKD). Nek8 is also associated with a rare form of juvenile renal cystic disease, nephronophthisis type 9. It has been suggested that a defect in the ciliary localization of Nek8 contributes to the development of cysts manifested by these diseases. Nek8 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270859 [Multi-domain]  Cd Length: 256  Bit Score: 94.80  E-value: 2.04e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIsPFEHQTYCQRT--LREIKILLRFRHENIIGINDiirapTIEQMKDV 101
Cdd:cd08220   1 KYEKIRVVGRGAYGTVYLCRRKDDNKLVIIKQI-PVEQMTKEERQaaLNEVKVLSMLHHPNIIEYYE-----SFLEDKAL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMET-DLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL-KICDFGLARVADP 176
Cdd:cd08220  75 MIVMEYAPGgTLFEYIQQRKgslLSEEEILHFFVQILLALHHVHSKQILHRDLKTQNILLNKKRTVvKIGDFGISKILSS 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 DHDhtgfLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhyldqlnhilgilgspsqedlncii 256
Cdd:cd08220 155 KSK----AYTVVGTPCYISPEL-CEGKPYNQKSDIWALGCVLYELASLKRAFEAA------------------------- 204
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 257 NLKArnylLSLphknKVPWNRLFPNADSKALDL---LDKMLTFNPHKRIEVEQALAHP 311
Cdd:cd08220 205 NLPA----LVL----KIMRGTFAPISDRYSEELrhlILSMLHLDPNKRPTLSEIMAQP 254
STKc_PLK1 cd14187
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the ...
24-228 2.39e-22

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK1 functions as a positive regulator of mitosis, meiosis, and cytokinesis. Its localization changes during mitotic progression; associating first with centrosomes in prophase, with kinetochores in prometaphase and metaphase, at the central spindle in anaphase, and in the midbody during telophase. It carries multiple functions throughout the cell cycle through interactions with differrent substrates at these specific subcellular locations. PLK1 is overexpressed in many human cancers and is associated with poor prognosis. The PLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271089 [Multi-domain]  Cd Length: 265  Bit Score: 95.00  E-value: 2.39e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMvCSAYDNVNKVRVAIKKISPFE-----HQTycQRTLREIKILLRFRHENIIGINDIIraptiEQM 98
Cdd:cd14187   8 RYVRGRFLGKGGFAK-CYEITDADTKEVFAGKIVPKSlllkpHQK--EKMSMEIAIHRSLAHQHVVGFHGFF-----EDN 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLMET----DLYKLLKTqhLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVA 174
Cdd:cd14187  80 DFVYVVLELCRRrsllELHKRRKA--LTEPEARYYLRQIILGCQYLHRNRVIHRDLKLGNLFLNDDMEVKIGDFGLATKV 157
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 175 DPDHDHTGFLteyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd14187 158 EYDGERKKTL---CGTPNYIAPEV-LSKKGHSFEVDIWSIGCIMYTLLVGKPPF 207
STKc_STK33 cd14097
Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the ...
25-313 2.49e-22

Catalytic domain of Serine/Threonine Kinase 33; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK33 is highly expressed in the testis and is present in low levels in most tissues. It may be involved in spermatogenesis and organ ontogenesis. It interacts with and phosphorylates vimentin and may be involved in regulating intermediate filament cytoskeletal dynamics. Its role in promoting the cell viability of KRAS-dependent cancer cells is under debate; some studies have found STK33 to promote cancer cell viability, while other studies have found it to be non-essential. KRAS is the most commonly mutated human oncogene, thus, studies on the role of STK33 in KRAS mutant cancer cells are important. The STK33 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270999 [Multi-domain]  Cd Length: 266  Bit Score: 94.92  E-value: 2.49e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTL-REIKILLRFRHENIIGINDIIRAPtieqmKDVYI 103
Cdd:cd14097   3 YTFGRKLGQGSFGVVIEATHKETQTKWAIKKINREKAGSSAVKLLeREVDILKHVNHAHIIHLEEVFETP-----KRMYL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYK--LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD-------LKICDFGLARVA 174
Cdd:cd14097  78 VMELCEDGELKelLLRKGFFSENETRHIIQSLASAVAYLHKNDIVHRDLKLENILVKSSIIdnndklnIKVTDFGLSVQK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 175 ---DPDHdhtgfLTEYVATRWYRAPEIMlNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhyldqlnhilgilgspSQED 251
Cdd:cd14097 158 yglGEDM-----LQETCGTPIYMAPEVI-SAHGYSQQCDIWSIGVIMYMLLCGEPPFVAK----------------SEEK 215
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916 252 LNCIINLKarnyllSLPHKNKVpWNRLfpnaDSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14097 216 LFEEIRKG------DLTFTQSV-WQSV----SDAAKNVLQQLLKVDPAHRMTASELLDNPWI 266
STKc_EIF2AK3_PERK cd14048
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
31-222 2.79e-22

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 3 or PKR-like Endoplasmic Reticulum Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PERK (or EIF2AK3) is a type-I ER transmembrane protein containing a luminal domain bound with the chaperone BiP under unstressed conditions and a cytoplasmic catalytic kinase domain. In response to the accumulation of misfolded or unfolded proteins in the ER, PERK is activated through the release of BiP, allowing it to dimerize and autophosphorylate. It functions as the central regulator of translational control during the Unfolded Protein Response (UPR) pathway. In addition to the eIF-2 alpha subunit, PERK also phosphorylates Nrf2, a leucine zipper transcription factor which regulates cellular redox status and promotes cell survival during the UPR. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PERK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270950 [Multi-domain]  Cd Length: 281  Bit Score: 94.94  E-value: 2.79e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIG-INDIIRAPTI---EQMKDVYI--- 103
Cdd:cd14048  14 LGRGGFGVVFEAKNKVDDCNYAVKRIRLPNNELAREKVLREVRALAKLDHPGIVRyFNAWLERPPEgwqEKMDEVYLyiq 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLL---KTQHLSNDHIC-YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHD 179
Cdd:cd14048  94 MQLCRKENLKDWMnrrCTMESRELFVClNIFKQIASAVEYLHSKGLIHRDLKPSNVFFSLDDVVKVGDFGLVTAMDQGEP 173
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 180 HTGFL---------TEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEML 222
Cdd:cd14048 174 EQTVLtpmpayakhTGQVGTRLYMSPE-QIHGNQYSEKVDIFALGLILFELI 224
STKc_Twitchin_like cd14114
The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs ...
24-313 4.44e-22

The catalytic domain of the Giant Serine/Threonine Kinases, Twitchin and Projectin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Caenorhabditis elegans and Aplysia californica Twitchin, Drosophila melanogaster Projectin, and similar proteins. These are very large muscle proteins containing multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains and a single kinase domain near the C-terminus. Twitchin and Projectin are both associated with thick filaments. Twitchin is localized in the outer parts of A-bands and is involved in regulating muscle contraction. It interacts with the myofibrillar proteins myosin and actin in a phosphorylation-dependent manner, and may be involved in regulating the myosin cross-bridge cycle. The kinase activity of Twitchen is activated by Ca2+ and the Ca2+ binding protein S100A1. Projectin is associated with the end of thick filaments and is a component of flight muscle connecting filaments. The kinase domain of Projectin may play roles in autophosphorylation and transphosphorylation, which impact the formation of myosin filaments. The Twitchin-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271016 [Multi-domain]  Cd Length: 259  Bit Score: 93.80  E-value: 4.44e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKvRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRaptiEQMKDVYI 103
Cdd:cd14114   3 HYDILEELGTGAFGVVHRCTERATG-NNFAAKFIMTPHESDKETVRKEIQIMNQLHHPKLINLHDAFE----DDNEMVLI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT--TCDLKICDFGLARVADPDHd 179
Cdd:cd14114  78 LEFLSGGELFERIAAEHykMSEAEVINYMRQVCEGLCHMHENNIVHLDIKPENIMCTTkrSNEVKLIDFGLATHLDPKE- 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 htgFLTEYVATRWYRAPEIMlNSKGYTKSIDIWSVGCILAEMLSNRPIFPGkhyldqlnhilgilgspsQEDLNCIINLK 259
Cdd:cd14114 157 ---SVKVTTGTAEFAAPEIV-EREPVGFYTDMWAVGVLSYVLLSGLSPFAG------------------ENDDETLRNVK 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 260 ARNYLLSLPHknkvpwnrlFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14114 215 SCDWNFDDSA---------FSGISEEAKDFIRKLLLADPNKRMTIHQALEHPWL 259
STKc_Sck1_like cd05586
Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine ...
31-221 5.86e-22

Catalytic domain of Suppressor of loss of cAMP-dependent protein kinase-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Schizosaccharomyces pombe Sck1 and similar fungal proteins. Sck1 plays a role in trehalase activation triggered by glucose and a nitrogen source. Trehalase catalyzes the cleavage of the disaccharide trehalose to glucose. Trehalose, as a carbohydrate reserve and stress metabolite, plays an important role in the response of yeast to environmental changes. The Sck1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270738 [Multi-domain]  Cd Length: 330  Bit Score: 94.94  E-value: 5.86e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFE--HQTYCQRTLREIKILLRFRHEN---IIGINDIIRAPTieqmkDVYIVQ 105
Cdd:cd05586   1 IGKGTFGQVYQVRKKDTRRIYAMKVLSKKVivAKKEVAHTIGERNILVRTALDEspfIVGLKFSFQTPT-----DLYLVT 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgf 183
Cdd:cd05586  76 DYMSGGelFWHLQKEGRFSEDRAKFYIAELVLALEHLHKNDIVYRDLKPENILLDANGHIALCDFGLSKADLTDNKTT-- 153
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 66932916 184 lTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEM 221
Cdd:cd05586 154 -NTFCGTTEYLAPEVLLDEKGYTKMVDFWSLGVLVFEM 190
STKc_EIF2AK2_PKR cd14047
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
25-223 6.25e-22

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Protein Kinase regulated by RNA; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKR (or EIF2AK2) contains an N-terminal double-stranded RNA (dsRNA) binding domain and a C-terminal catalytic kinase domain. It is activated by dsRNA, which is produced as a replication intermediate in virally infected cells. It plays a key role in mediating innate immune responses to viral infection. PKR is also directly activated by PACT (protein activator of PKR) and heparin, and is inhibited by viral proteins and RNAs. PKR also regulates transcription and signal transduction in diseased cells, playing roles in tumorigenesis and neurodegenerative diseases. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The PKR subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270949 [Multi-domain]  Cd Length: 267  Bit Score: 93.71  E-value: 6.25e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIspfehQTYCQRTLREIKILLRFRHENII-------GINDII----RAP 93
Cdd:cd14047   8 FKEIELIGSGGFGQVFKAKHRIDGKTYAIKRV-----KLNNEKAEREVKALAKLDHPNIVryngcwdGFDYDPetssSNS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  94 TIEQMKDVYIVQDLMETDLYK--LLKTQHLSNDH--ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 169
Cdd:cd14047  83 SRSKTKCLFIQMEFCEKGTLEswIEKRNGEKLDKvlALEIFEQITKGVEYIHSKKLIHRDLKPSNIFLVDTGKVKIGDFG 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 170 L-ARVADPdhdhtGFLTEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd14047 163 LvTSLKND-----GKRTKSKGTLSYMSPE-QISSQDYGKEVDIYALGLILFELLH 211
PTKc_Src_like cd05034
Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
31-232 6.37e-22

Catalytic domain of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src subfamily members include Src, Lck, Hck, Blk, Lyn, Fgr, Fyn, Yrk, and Yes. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Src kinases are overexpressed in a variety of human cancers, making them attractive targets for therapy. They are also implicated in acute inflammatory responses and osteoclast function. Src, Fyn, Yes, and Yrk are widely expressed, while Blk, Lck, Hck, Fgr, and Lyn show a limited expression pattern. The Src-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270630 [Multi-domain]  Cd Length: 248  Bit Score: 93.12  E-value: 6.37e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNvNKVRVAIKKISPfeHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLMET 110
Cdd:cd05034   3 LGAGQFGEVWMGVWN-GTTKVAVKTLKP--GTMSPEAFLQEAQIMKKLRHDKLVQLYAVC-----SDEEPIYIVTELMSK 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 -DLYKLLKTQHLSNDHI---CYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDhdhtgfltE 186
Cdd:cd05034  75 gSLLDYLRTGEGRALRLpqlIDMAAQIASGMAYLESRNYIHRDLAARNILVGENNVCKVADFGLARLIEDD--------E 146
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 187 YVA-------TRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLS-NRPIFPGKH 232
Cdd:cd05034 147 YTAregakfpIKW-TAPEAALYGRFTIKS-DVWSFGILLYEIVTyGRVPYPGMT 198
STKc_IRE1 cd13982
Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze ...
50-312 6.55e-22

Catalytic domain of the Serine/Threonine kinase, Inositol-requiring protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRE1, also called Endoplasmic reticulum (ER)-to-nucleus signaling protein (or ERN), is an ER-localized type I transmembrane protein with kinase and endoribonuclease domains in the cytoplasmic side. It acts as an ER stress sensor and is the oldest and most conserved component of the unfolded protein response (UPR) in eukaryotes. The UPR is activated when protein misfolding is detected in the ER in order to decrease the synthesis of new proteins and increase the capacity of the ER to cope with the stress. During ER stress, IRE1 dimerizes and forms oligomers, allowing the kinase domain to undergo trans-autophosphorylation. This leads to a conformational change that stimulates its endoribonuclease activity and results in the cleavage of its mRNA substrate, HAC1 in yeast and XBP1 in metazoans, promoting a splicing event that enables translation into a transcription factor which activates the UPR. Mammals contain two IRE1 proteins, IRE1alpha (or ERN1) and IRE1beta (or ERN2). The Ire1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270884 [Multi-domain]  Cd Length: 269  Bit Score: 93.49  E-value: 6.55e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  50 RVAIKKISPfehqTYCQRTLREIKILLRF-RHENIIgindiiRAPTIEQMKD-VYIVQDLMETDLYKLLKTQHLSNDHI- 126
Cdd:cd13982  27 PVAVKRLLP----EFFDFADREVQLLRESdEHPNVI------RYFCTEKDRQfLYIALELCAASLQDLVESPRESKLFLr 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 127 ----CY-FLYQILRGLKYIHSANVLHRDLKPSNLLLNT-----TCDLKICDFGLARVADpDHDHTGFLTEYVA-TRWYRA 195
Cdd:cd13982  97 pglePVrLLRQIASGLAHLHSLNIVHRDLKPQNILISTpnahgNVRAMISDFGLCKKLD-VGRSSFSRRSGVAgTSGWIA 175
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 196 PEIMLNSKGY--TKSIDIWSVGCILAEMLSNrpifpGKHyldqlnhilgILGSPSQEDLNCIINLKARNYLLSLPHKNKV 273
Cdd:cd13982 176 PEMLSGSTKRrqTRAVDIFSLGCVFYYVLSG-----GSH----------PFGDKLEREANILKGKYSLDKLLSLGEHGPE 240
                       250       260       270
                ....*....|....*....|....*....|....*....
gi 66932916 274 pwnrlfpnadskALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd13982 241 ------------AQDLIERMIDFDPEKRPSAEEVLNHPF 267
STKc_MAPKAPK5 cd14171
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
49-313 8.02e-22

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 5 (MAPKAP5 or MK5) is also called PRAK (p38-regulated/activated protein kinase). It contains a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK5 is a ubiquitous protein that is implicated in neuronal morphogenesis, cell migration, and tumor angiogenesis. It interacts with PKA, which induces cytoplasmic translocation of MK5. Its substrates includes p53, ERK3/4, Hsp27, and cytosolic phospholipase A2 (cPLA2). The MAPKAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271073 [Multi-domain]  Cd Length: 289  Bit Score: 93.68  E-value: 8.02e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  49 VRVAIKKISPFEHQTYC--QRTLREIKILLRFR---HENIIGI-----NDIIRAPTIEQMKDVYIVQDLME-TDLY-KLL 116
Cdd:cd14171  22 VRVCVKKSTGERFALKIllDRPKARTEVRLHMMcsgHPNIVQIydvyaNSVQFPGESSPRARLLIVMELMEgGELFdRIS 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 117 KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFGLARVADPDHDHTGFLTEYVATRWY 193
Cdd:cd14171 102 QHRHFTEKQAAQYTKQIALAVQHCHSLNIAHRDLKPENLLLKDNSEdapIKLCDFGFAKVDQGDLMTPQFTPYYVAPQVL 181
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 194 RAPE--------IMLNSKGYT--KSIDIWSVGCILAEMLSNRPIFPGKHyldqlnhilgilgsPSQEdlnciINLKARNY 263
Cdd:cd14171 182 EAQRrhrkersgIPTSPTPYTydKSCDMWSLGVIIYIMLCGYPPFYSEH--------------PSRT-----ITKDMKRK 242
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 264 LLSLPHKnkvpwnrlFPNADSK-----ALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14171 243 IMTGSYE--------FPEEEWSqisemAKDIVRKLLCVDPEERMTIEEVLHHPWL 289
PTKc_Jak_rpt2 cd05038
Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily ...
26-223 9.24e-22

Catalytic (repeat 2) domain of the Protein Tyrosine Kinases, Janus kinases; The Jak subfamily is composed of Jak1, Jak2, Jak3, TYK2, and similar proteins. They are PTKs, catalyzing the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jaks are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Most Jaks are expressed in a wide variety of tissues, except for Jak3, which is expressed only in hematopoietic cells. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). Jaks are also involved in regulating the surface expression of some cytokine receptors. The Jak-STAT pathway is involved in many biological processes including hematopoiesis, immunoregulation, host defense, fertility, lactation, growth, and embryogenesis. The Jak subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270634 [Multi-domain]  Cd Length: 284  Bit Score: 93.60  E-value: 9.24e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  26 TNLSYIGEGAYGMVCSA-YDNVN---KVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKdv 101
Cdd:cd05038   7 KFIKQLGEGHFGSVELCrYDPLGdntGEQVAVKSLQPSGEEQHMSDFKREIEILRTLDHEYIVKYKGVCESPGRRSLR-- 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMETDLYKLLKTQHLSNDHICYFLY--QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHD 179
Cdd:cd05038  85 LIMEYLPSGSLRDYLQRHRDQIDLKRLLLFasQICKGMEYLGSQRYIHRDLAARNILVESEDLVKISDFGLAKVLPEDKE 164
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 180 HtgflteYVAT-------RWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05038 165 Y------YYVKepgespiFWY-APECLRESRFSSAS-DVWSFGVTLYELFT 207
STKc_IRAK cd14066
Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases ...
31-226 9.32e-22

Catalytic domain of the Serine/Threonine kinases, Interleukin-1 Receptor Associated Kinases and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. Some IRAKs may also play roles in T- and B-cell signaling, and adaptive immunity. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK-1, -2, and -4 are ubiquitously expressed and are active kinases, while IRAK-M is only induced in monocytes and macrophages and is an inactive kinase. Variations in IRAK genes are linked to diverse diseases including infection, sepsis, cancer, and autoimmune diseases. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain (a pseudokinase domain in the case of IRAK3), and a C-terminal domain; IRAK-4 lacks the C-terminal domain. This subfamily includes plant receptor-like kinases (RLKs) including Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1). BAK1 functions in BR (brassinosteroid)-regulated plant development and in pathways involved in plant resistance to pathogen infection and herbivore attack. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The IRAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270968 [Multi-domain]  Cd Length: 272  Bit Score: 93.11  E-value: 9.32e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVrVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIgindIIRAPTIEQmKDVYIVQDLMET 110
Cdd:cd14066   1 IGSGGFGTVYKGVLENGTV-VAVKRLNEMNCAASKKEFLTELEMLGRLRHPNLV----RLLGYCLES-DEKLLVYEYMPN 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 -DLYKLLKTQHLSNDH-------ICyflYQILRGLKYIHSAN---VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDhD 179
Cdd:cd14066  75 gSLEDRLHCHKGSPPLpwpqrlkIA---KGIARGLEYLHEECpppIIHGDIKSSNILLDEDFEPKLTDFGLARLIPPS-E 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 180 HTGFLTEYVATRWYRAPEIMlNSKGYTKSIDIWSVGCILAEMLSNRP 226
Cdd:cd14066 151 SVSKTSAVKGTIGYLAPEYI-RTGRVSTKSDVYSFGVVLLELLTGKP 196
PTZ00284 PTZ00284
protein kinase; Provisional
13-317 1.58e-21

protein kinase; Provisional


Pssm-ID: 140307 [Multi-domain]  Cd Length: 467  Bit Score: 95.42  E-value: 1.58e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   13 MVRGQVFDVGP-RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTycqrtlREIKILLRFRHEniigindiIR 91
Cdd:PTZ00284 118 VVLGEDIDVSTqRFKILSLLGEGTFGKVVEAWDRKRKEYCAVKIVRNVPKYT------RDAKIEIQFMEK--------VR 183
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   92 APTIEQMKDVYIVQDLMETD---------------LYKLLKTQHLSNDHICYFLYQILRGLKYIHSA-NVLHRDLKPSNL 155
Cdd:PTZ00284 184 QADPADRFPLMKIQRYFQNEtghmcivmpkygpclLDWIMKHGPFSHRHLAQIIFQTGVALDYFHTElHLMHTDLKPENI 263
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  156 LLNTT----------------CDLKICDFGlaRVADPDHDHTGFlteyVATRWYRAPEIMLnSKGYTKSIDIWSVGCILA 219
Cdd:PTZ00284 264 LMETSdtvvdpvtnralppdpCRVRICDLG--GCCDERHSRTAI----VSTRHYRSPEVVL-GLGWMYSTDMWSMGCIIY 336
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  220 EMLSNRPIFPGKHYLDQLNHILGILGS-PSQEDLNCIINlKARNYLLSLPHknkvpwnrLFPNADSKAL----------- 287
Cdd:PTZ00284 337 ELYTGKLLYDTHDNLEHLHLMEKTLGRlPSEWAGRCGTE-EARLLYNSAGQ--------LRPCTDPKHLariararpvre 407
                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 66932916  288 --------DLLDKMLTFNPHKRIEVEQALAHPYLEQYY 317
Cdd:PTZ00284 408 virddllcDLIYGLLHYDRQKRLNARQMTTHPYVLKYY 445
STKc_Aurora-A cd14116
Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer ...
31-313 1.76e-21

Catalytic domain of the Serine/Threonine kinase, Aurora-A kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). Aurora-A regulates cell cycle events from the late S-phase through the M-phase including centrosome maturation, mitotic entry, centrosome separation, spindle assembly, chromosome alignment, cytokinesis, and mitotic exit. Aurora-A activation depends on its autophosphorylation and binding to the microtubule-associated protein TPX2, which also localizes the kinase to spindle microtubules. Aurora-A is overexpressed in many cancer types such as prostate, ovarian, breast, bladder, gastric, and pancreatic. The Aurora subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271018 [Multi-domain]  Cd Length: 258  Bit Score: 92.33  E-value: 1.76e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKI-------SPFEHQTYcqrtlREIKILLRFRHENIIGI----NDIIRaptieqmk 99
Cdd:cd14116  13 LGKGKFGNVYLAREKQSKFILALKVLfkaqlekAGVEHQLR-----REVEIQSHLRHPNILRLygyfHDATR-------- 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 dVYIVQDLMET-DLYK-LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARvadpd 177
Cdd:cd14116  80 -VYLILEYAPLgTVYReLQKLSKFDEQRTATYITELANALSYCHSKRVIHRDIKPENLLLGSAGELKIADFGWSV----- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HDHTGFLTEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYldqlnhilgilgspsQEDLNCIIN 257
Cdd:cd14116 154 HAPSSRRTTLCGTLDYLPPE-MIEGRMHDEKVDLWSLGVLCYEFLVGKPPFEANTY---------------QETYKRISR 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 258 LKarnylLSLPhknkvpwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14116 218 VE-----FTFP-----------DFVTEGARDLISRLLKHNPSQRPMLREVLEHPWI 257
STKc_PLK3 cd14189
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the ...
25-313 1.84e-21

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK3, also called Prk or Fnk (FGF-inducible kinase), regulates angiogenesis and responses to DNA damage. Activated PLK3 mediates Chk2 phosphorylation by ATM and the resulting checkpoint activation. PLK3 phosphorylates DNA polymerase delta and may be involved in DNA repair. It also inhibits Cdc25c, thereby regulating the onset of mitosis. The PLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271091 [Multi-domain]  Cd Length: 255  Bit Score: 92.30  E-value: 1.84e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE----HQTycQRTLREIKILLRFRHENIIGINDiirapTIEQMKD 100
Cdd:cd14189   3 YCKGRLLGKGGFARCYEMTDLATNKTYAVKVIPHSRvakpHQR--EKIVNEIELHRDLHHKHVVKFSH-----HFEDAEN 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLM-ETDLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDH 178
Cdd:cd14189  76 IYIFLELCsRKSLAHIWKARHtLLEPEVRYYLKQIISGLKYLHLKGILHRDLKLGNFFINENMELKVGDFGLAARLEPPE 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 DHTGFLteyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPgkhyldqlnhilgilGSPSQEDLNCIINL 258
Cdd:cd14189 156 QRKKTI---CGTPNYLAPEV-LLRQGHGPESDVWSLGCVMYTLLCGNPPFE---------------TLDLKETYRCIKQV 216
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 259 KarnylLSLPHKNKVPwnrlfpnadskALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14189 217 K-----YTLPASLSLP-----------ARHLLAGILKRNPGDRLTLDQILEHEFF 255
STKc_EIF2AK1_HRI cd14049
Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor ...
25-222 1.95e-21

Catalytic domain of the Serine/Threonine kinase, eukaryotic translation Initiation Factor 2-Alpha Kinase 2 or Heme-Regulated Inhibitor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HRI (or EIF2AK1) contains an N-terminal regulatory heme-binding domain and a C-terminal catalytic kinase domain. It is suppressed under normal conditions by binding of the heme iron, and is activated during heme deficiency. It functions as a critical regulator that ensures balanced synthesis of globins and heme, in order to form stable hemoglobin during erythroid differentiation and maturation. HRI also protects cells and enhances survival under iron-deficient conditions. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the downregulation of protein synthesis. The HRI subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270951 [Multi-domain]  Cd Length: 284  Bit Score: 92.57  E-value: 1.95e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRTLREIKILLRFRHENIIGindiIRAPTIEQMK-DVY 102
Cdd:cd14049   8 FEEIARLGKGGYGKVYKVRNKLDGQYYAIKKILiKKVTKRDCMKVLREVKVLAGLQHPNIVG----YHTAWMEHVQlMLY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLL--------KTQHLSN-------DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKIC 166
Cdd:cd14049  84 IQMQLCELSLWDWIvernkrpcEEEFKSApytpvdvDVTTKILQQLLEGVTYIHSMGIVHRDLKPRNIFLHgSDIHVRIG 163
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 167 DFGLA----RVADPDHDHTGFL-----TEYVATRWYRAPEIMLNSKGYTKSiDIWSVGCILAEML 222
Cdd:cd14049 164 DFGLAcpdiLQDGNDSTTMSRLnglthTSGVGTCLYAAPEQLEGSHYDFKS-DMYSIGVILLELF 227
PKc_Byr1_like cd06620
Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; ...
28-326 2.31e-21

Catalytic domain of fungal Byr1-like dual-specificity Mitogen-activated protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Byr1 from Schizosaccharomyces pombe, FUZ7 from Ustilago maydis, and related proteins. Byr1 phosphorylates its downstream target, the MAPK Spk1, and is regulated by the MAPKK kinase Byr2. The Spk1 cascade is pheromone-responsive and is essential for sporulation and sexual differentiation in fission yeast. FUZ7 phosphorylates and activates its target, the MAPK Crk1, which is required in mating and virulence in U. maydis. MAPK signaling pathways are important mediators of cellular responses to extracellular signals. The Byr-1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270792 [Multi-domain]  Cd Length: 286  Bit Score: 92.50  E-value: 2.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGMVcSAYDNVNKVRVAIKKISPFEHQTYCQRT-LREIKILLRFRHENIIGIndiiRAPTIEQMKDVYIVQD 106
Cdd:cd06620  10 LKDLGAGNGGSV-SKVLHIPTGTIMAKKVIHIDAKSSVRKQiLRELQILHECHSPYIVSF----YGAFLNENNNIIICME 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LMETD----LYKLLKTqhLSNDHICYFLYQILRGLKYIHSA-NVLHRDLKPSNLLLNTTCDLKICDFGLAR-----VADp 176
Cdd:cd06620  85 YMDCGsldkILKKKGP--FPEEVLGKIAVAVLEGLTYLYNVhRIIHRDIKPSNILVNSKGQIKLCDFGVSGelinsIAD- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 dhdhtgfltEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILgspsqEDLNCI 255
Cdd:cd06620 162 ---------TFVGTSTYMSPE-RIQGGKYSVKSDVWSLGLSIIELALGEfPFAGSNDDDDGYNGPMGIL-----DLLQRI 226
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 256 INLKArnyllslPhknKVPWNRLFPnadSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIAE 326
Cdd:cd06620 227 VNEPP-------P---RLPKDRIFP---KDLRDFVDRCLLKDPRERPSPQLLLDHDPFIQAVRASDVDLRA 284
STKc_Kin1_2 cd14077
Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the ...
31-313 2.43e-21

Catalytic domain of Kin1, Kin2, and simlar Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of yeast Kin1, Kin2, and similar proteins. Fission yeast Kin1 is a membrane-associated kinase that is involved in regulating cell surface cohesiveness during interphase. It also plays a role during mitosis, linking actomyosin ring assembly with septum synthesis and membrane closure to ensure separation of daughter cells. Budding yeast Kin1 and Kin2 act downstream of the Rab-GTPase Sec4 and are associated with the exocytic apparatus; they play roles in the secretory pathway. The Kin1/2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270979 [Multi-domain]  Cd Length: 267  Bit Score: 92.13  E-value: 2.43e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKkISPFEHQTYC---------------QRTLREIKILLRFRHENIIGINDIIRAPTI 95
Cdd:cd14077   9 IGAGSMGKVKLAKHIRTGEKCAIK-IIPRASNAGLkkerekrlekeisrdIRTIREAALSSLLNHPHICRLRDFLRTPNH 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  96 EQMKDVYIVQDLMetdLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD 175
Cdd:cd14077  88 YYMLFEYVDGGQL---LDYIISHGKLKEKQARKFARQIASALDYLHRNSIVHRDLKIENILISKSGNIKIIDFGLSNLYD 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 PDHdhtgFLTEYVATRWYRAPEiMLNSKGYT-KSIDIWSVGCILAEMLSNRPIFPgkhylDQLNHILgilgspsQEDLNc 254
Cdd:cd14077 165 PRR----LLRTFCGSLYFAAPE-LLQAQPYTgPEVDVWSFGVVLYVLVCGKVPFD-----DENMPAL-------HAKIK- 226
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 255 iinlkarnyllslphKNKVPwnrlFPN-ADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14077 227 ---------------KGKVE----YPSyLSSECKSLISRMLVVDPKKRATLEQVLNHPWM 267
STKc_GAK_like cd13985
Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of ...
31-222 2.60e-21

Catalytic domain of cyclin G-Associated Kinase-like proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes cyclin G-Associated Kinase (GAK), Drosophila melanogaster Numb-Associated Kinase (NAK)-like proteins, and similar protein kinases. GAK plays regulatory roles in clathrin-mediated membrane trafficking, the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses. NAK plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. The GAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270887 [Multi-domain]  Cd Length: 272  Bit Score: 92.01  E-value: 2.60e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYcQRTLREIKILLRF-RHENIIGIND--IIRaptIEQMKDVYIVQDL 107
Cdd:cd13985   8 LGEGGFSYVYLAHDVNTGRRYALKRMYFNDEEQL-RVAIKEIEIMKRLcGHPNIVQYYDsaILS---SEGRKEVLLLMEY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METDLYKLLKTQ---HLSNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNTTCDLKICDFGLA----------- 171
Cdd:cd13985  84 CPGSLVDILEKSppsPLSEEEVLRIFYQICQAVGHLHSQSppIIHRDIKIENILFSNTGRFKLCDFGSAttehyplerae 163
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 172 RVADPDHDhtgfLTEYVaTRWYRAPEiMLNSKGY---TKSIDIWSVGCILAEML 222
Cdd:cd13985 164 EVNIIEEE----IQKNT-TPMYRAPE-MIDLYSKkpiGEKADIWALGCLLYKLC 211
PKc_Myt1 cd14050
Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze ...
25-311 3.37e-21

Catalytic domain of the Dual-specificity protein kinase, Myt1; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. Myt1 is a cytoplasmic cell cycle checkpoint kinase that can keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of N-terminal thr (T14) and tyr (Y15) residues, leading to the delay of meiosis I entry. Meiotic progression is ensured by a two-step inhibition and downregulation of Myt1 by CDK1/XRINGO and p90Rsk during oocyte maturation. In addition, Myt1 targets cyclin B1/B2 and is essential for Golgi and ER assembly during telophase. In Drosophila, Myt1 may be a downstream target of Notch during eye development. The Myt1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270952 [Multi-domain]  Cd Length: 249  Bit Score: 91.22  E-value: 3.37e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI-SPFEHQTYCQRTLREIKILLRF-RHENIIGIndiIRAptIEQMKDVY 102
Cdd:cd14050   3 FTILSKLGEGSFGEVFKVRSREDGKLYAVKRSrSRFRGEKDRKRKLEEVERHEKLgEHPNCVRF---IKA--WEEKGILY 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYK-LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLarVADPDHDHT 181
Cdd:cd14050  78 IQTELCDTSLQQyCEETHSLPESEVWNILLDLLKGLKHLHDHGLIHLDIKPANIFLSKDGVCKLGDFGL--VVELDKEDI 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLTEYVATrwYRAPEIMLNSkgYTKSIDIWSVGCILAEMLSNrpifpgkhyldqlnhilgilgspsqedlnciinlkar 261
Cdd:cd14050 156 HDAQEGDPR--YMAPELLQGS--FTKAADIFSLGITILELACN------------------------------------- 194
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 262 nylLSLPhKNKVPWNRL--------FPNADSKAL-DLLDKMLTFNPHKRIEVEQALAHP 311
Cdd:cd14050 195 ---LELP-SGGDGWHQLrqgylpeeFTAGLSPELrSIIKLMMDPDPERRPTAEDLLALP 249
STKc_MEKK2 cd06652
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
31-264 4.31e-21

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK2 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK2 also activates ERK1/2, c-Jun N-terminal kinase (JNK) and p38 through their respective MAPKKs MEK1/2, JNK-activating kinase 2 (JNKK2), and MKK3/6. MEKK2 plays roles in T cell receptor signaling, immune synapse formation, cytokine gene expression, as well as in EGF and FGF receptor signaling. The MEKK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270818 [Multi-domain]  Cd Length: 264  Bit Score: 91.26  E-value: 4.31e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKI-----SPfEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPtieQMKDVYIVQ 105
Cdd:cd06652  10 LGQGAFGRVYLCYDADTGRELAVKQVqfdpeSP-ETSKEVNALECEIQLLKNLLHERIVQYYGCLRDP---QERTLSIFM 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETDLYK--LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-RVADPDHDHTG 182
Cdd:cd06652  86 EYMPGGSIKdqLKSYGALTENVTRKYTRQILEGVHYLHSNMIVHRDIKGANILRDSVGNVKLGDFGASkRLQTICLSGTG 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 183 fLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPifPGKHYlDQLNHILGILGSPSQEDLNCIINLKARN 262
Cdd:cd06652 166 -MKSVTGTPYWMSPEV-ISGEGYGRKADIWSVGCTVVEMLTEKP--PWAEF-EAMAAIFKIATQPTNPQLPAHVSDHCRD 240

                ..
gi 66932916 263 YL 264
Cdd:cd06652 241 FL 242
STKc_SIK cd14071
Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the ...
31-313 5.06e-21

Catalytic domain of the Serine/Threonine Kinases, Salt-Inducible kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SIKs are part of a complex network that regulates Na,K-ATPase to maintain sodium homeostasis and blood pressure. Vertebrates contain three forms of SIKs (SIK1-3) from three distinct genes, which display tissue-specific effects. SIK1, also called SNF1LK, controls steroidogenic enzyme production in adrenocortical cells. In the brain, both SIK1 and SIK2 regulate energy metabolism. SIK2, also called QIK or SNF1LK2, is involved in the regulation of gluconeogenesis in the liver and lipogenesis in adipose tissues, where it phosphorylates the insulin receptor substrate-1. In the liver, SIK3 (also called QSK) regulates cholesterol and bile acid metabolism. In addition, SIK2 plays an important role in the initiation of mitosis and regulates the localization of C-Nap1, a centrosome linker protein. The SIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270973 [Multi-domain]  Cd Length: 253  Bit Score: 90.91  E-value: 5.06e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFE-HQTYCQRTLREIKILLRFRHENIIGINDIIRAptiEQMkdVYIVQDLME 109
Cdd:cd14071   8 IGKGNFAVVKLARHRITKTEVAIKIIDKSQlDEENLKKIYREVQIMKMLNHPHIIKLYQVMET---KDM--LYLVTEYAS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 T-DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHdhtgFLTEY 187
Cdd:cd14071  83 NgEIFDYLAQHgRMSEKEARKKFWQILSAVEYCHKRHIVHRDLKAENLLLDANMNIKIADFGFSNFFKPGE----LLKTW 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 188 VATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGkhyldqlnhilgilgspsqedlNCIINLKARnyllSL 267
Cdd:cd14071 159 CGSPPYAAPEVFEGKEYEGPQLDIWSLGVVLYVLVCGALPFDG----------------------STLQTLRDR----VL 212
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 66932916 268 PHKNKVPWnrlFPNADSKalDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14071 213 SGRFRIPF---FMSTDCE--HLIRRMLVLDPSKRLTIEQIKKHKWM 253
STKc_obscurin_rpt1 cd14107
Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
31-313 6.07e-21

Catalytic kinase domain, first repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271009 [Multi-domain]  Cd Length: 257  Bit Score: 90.72  E-value: 6.07e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIsPFEHQTYCqRTLREIKILLRFRHENIIGINDiirapTIEQMKDVYIVQDLMET 110
Cdd:cd14107  10 IGRGTFGFVKRVTHKGNGECCAAKFI-PLRSSTRA-RAFQERDILARLSHRRLTCLLD-----QFETRKTLILILELCSS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 D--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL--NTTCDLKICDFGLARVADP-DHDHTGFLT 185
Cdd:cd14107  83 EelLDRLFLKGVVTEAEVKLYIQQVLEGIGYLHGMNILHLDIKPDNILMvsPTREDIKICDFGFAQEITPsEHQFSKYGS 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 -EYVatrwyrAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGkhyldqlnhilgilgspsQEDLNCIINLKarnyl 264
Cdd:cd14107 163 pEFV------APEIVHQEP-VSAATDIWALGVIAYLSLTCHSPFAG------------------ENDRATLLNVA----- 212
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 265 lslphKNKVPWNR-LFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14107 213 -----EGVVSWDTpEITHLSEDAKDFIKRVLQPDPEKRPSASECLSHEWF 257
STKc_TAO2 cd06634
Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze ...
25-350 7.18e-21

Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Human TAO2 is also known as prostate-derived Ste20-like kinase (PSK) and was identified in a screen for overexpressed RNAs in prostate cancer. TAO2 possesses mitogen-activated protein kinase (MAPK) kinase kinase activity and activates both p38 and c-Jun N-terminal kinase (JNK), by phosphorylating and activating their respective MAP/ERK kinases, MEK3/MEK6 and MKK4/MKK7. It contains a long C-terminal extension with autoinhibitory segments, and is activated by the release of this inhibition and the phosphorylation of its activation loop serine. TAO2 functions as a regulator of actin cytoskeletal and microtubule organization. In addition, it regulates the transforming growth factor-activated kinase 1 (TAK1), which is a MAPKKK that plays an essential role in the signaling pathways of tumor necrosis factor, interleukin 1, and Toll-like receptor. The TAO2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270804 [Multi-domain]  Cd Length: 308  Bit Score: 91.62  E-value: 7.18e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQT--YCQRTLREIKILLRFRHENIIgindiiraptieQMKDVY 102
Cdd:cd06634  17 FSDLREIGHGSFGAVYFARDVRNNEVVAIKKMSYSGKQSneKWQDIIKEVKFLQKLRHPNTI------------EYRGCY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQD----LME------TDLYKLLKtQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR 172
Cdd:cd06634  85 LREHtawlVMEyclgsaSDLLEVHK-KPLQEVEIAAITHGALQGLAYLHSHNMIHRDVKAGNILLTEPGLVKLGDFGSAS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 VADPDHdhtgfltEYVATRWYRAPEIML--NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqe 250
Cdd:cd06634 164 IMAPAN-------SFVGTPYWMAPEVILamDEGQYDGKVDVWSLGITCIELAERKPPLFNMNAMSALYHI---------- 226
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 251 dlnciinlkARNyllSLPHKNKVPWNRLFPNadskaldLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPS--DEPIAEAP 328
Cdd:cd06634 227 ---------AQN---ESPALQSGHWSEYFRN-------FVDSCLQKIPQDRPTSDVLLKHRFLLRERPPTviMDLIQRTK 287
                       330       340
                ....*....|....*....|..
gi 66932916 329 FKFdMELDDLPKEKLKELIFEE 350
Cdd:cd06634 288 DAV-RELDNLQYRKMKKILFQE 308
STKc_cGK cd05572
Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); ...
31-278 9.20e-21

Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mammals have two cGK isoforms from different genes, cGKI and cGKII. cGKI exists as two splice variants, cGKI-alpha and cGKI-beta. cGK consists of an N-terminal regulatory domain containing a dimerization and an autoinhibitory pseudosubstrate region, two cGMP-binding domains, and a C-terminal catalytic domain. Binding of cGMP to both binding sites releases the inhibition of the catalytic center by the pseudosubstrate region, allowing autophosphorylation and activation of the kinase. cGKI is a soluble protein expressed in all smooth muscles, platelets, cerebellum, and kidney. It is also expressed at lower concentrations in other tissues. cGKII is a membrane-bound protein that is most abundantly expressed in the intestine. It is also present in the brain nuclei, adrenal cortex, kidney, lung, and prostate. cGKI is involved in the regulation of smooth muscle tone, smooth cell proliferation, and platelet activation. cGKII plays a role in the regulation of secretion, such as renin secretion by the kidney and aldosterone secretion by the adrenal. It also regulates bone growth and the circadian rhythm. The cGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270724 [Multi-domain]  Cd Length: 262  Bit Score: 90.36  E-value: 9.20e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYG---MVCSAYDNVNKVRVAIKKISPFehQTYCQRTL-REIKILLRFRHENIIGINDiirapTIEQMKDVYIVQD 106
Cdd:cd05572   1 LGVGGFGrveLVQLKSKGRTFALKCVKKRHIV--QTRQQEHIfSEKEILEECNSPFIVKLYR-----TFKDKKYLYMLME 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LME-TDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHD-HTgf 183
Cdd:cd05572  74 YCLgGELWTILRDRgLFDEYTARFYTACVVLAFEYLHSRGIIYRDLKPENLLLDSNGYVKLVDFGFAKKLGSGRKtWT-- 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 lteYVATRWYRAPEIMLNsKGYTKSIDIWSVGCILAEMLSNRPIF------PGKHYLDQLNHIlGILGSPSqedlncIIN 257
Cdd:cd05572 152 ---FCGTPEYVAPEIILN-KGYDFSVDYWSLGILLYELLTGRPPFggddedPMKIYNIILKGI-DKIEFPK------YID 220
                       250       260
                ....*....|....*....|.
gi 66932916 258 LKARNYLLSLPHKNkvPWNRL 278
Cdd:cd05572 221 KNAKNLIKQLLRRN--PEERL 239
STKc_DCKL1 cd14183
Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called ...
21-313 1.06e-20

Catalytic domain of the Serine/Threonine Kinase, Doublecortin-like kinase 1 (also called Doublecortin-like and CAM kinase-like 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DCKL1 (or DCAMKL1) belongs to the doublecortin (DCX) family of proteins which are involved in neuronal migration, neurogenesis, and eye receptor development, among others. Family members typically contain tandem doublecortin (DCX) domains at the N-terminus; DCX domains can bind microtubules and serve as protein-interaction platforms. In addition, DCKL1 contains a serine, threonine, and proline rich domain (SP) and a C-terminal kinase domain with similarity to CAMKs. DCKL1 interacts with tubulin, glucocorticoid receptor, dynein, JIP1/2, caspases (3 and 8), and calpain, among others. It plays roles in neurogenesis, neuronal migration, retrograde transport, and neuronal apoptosis. The DCKL1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271085 [Multi-domain]  Cd Length: 268  Bit Score: 90.44  E-value: 1.06e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  21 VGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTieqmkD 100
Cdd:cd14183   4 ISERYKVGRTIGDGNFAVVKECVERSTGREYALKIINKSKCRGKEHMIQNEVSILRRVKHPNIVLLIEEMDMPT-----E 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLMET-DLYK-LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD----LKICDFGLARVA 174
Cdd:cd14183  79 LYLVMELVKGgDLFDaITSTNKYTERDASGMLYNLASAIKYLHSLNIVHRDIKPENLLVYEHQDgsksLKLGDFGLATVV 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 175 DpdhdhtGFLTEYVATRWYRAPEIMLNSkGYTKSIDIWSVGCILAEMLSNRPIFPG-----KHYLDQLnhILGILGSPSq 249
Cdd:cd14183 159 D------GPLYTVCGTPTYVAPEIIAET-GYGLKVDIWAAGVITYILLCGFPPFRGsgddqEVLFDQI--LMGQVDFPS- 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916 250 edlnciinlkarnyllslPHknkvpWNrlfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14183 229 ------------------PY-----WD----NVSDSAKELITMMLQVDVDQRYSALQVLEHPWV 265
PTKc_EphR_A2 cd05063
Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the ...
31-239 1.08e-20

Catalytic domain of the Protein Tyrosine Kinase, Ephrin Receptor A2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The EphA2 receptor is overexpressed in tumor cells and tumor blood vessels in a variety of cancers including breast, prostate, lung, and colon. As a result, it is an attractive target for drug design since its inhibition could affect several aspects of tumor progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 133194 [Multi-domain]  Cd Length: 268  Bit Score: 90.42  E-value: 1.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNV---NKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDL 107
Cdd:cd05063  13 IGAGEFGEVFRGILKMpgrKEVAVAIKTLKPGYTEKQRQDFLSEASIMGQFSHHNIIRLEGVV-----TKFKPAMIITEY 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METD-LYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgFL 184
Cdd:cd05063  88 MENGaLDKYLRDHdgEFSSYQLVGMLRGIAAGMKYLSDMNYVHRDLAARNILVNSNLECKVSDFGLSRVLEDDPEGT-YT 166
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 185 TE--YVATRWyRAPEIMLNSKgYTKSIDIWSVGCILAEMLSnrpiFPGKHYLDQLNH 239
Cdd:cd05063 167 TSggKIPIRW-TAPEAIAYRK-FTSASDVWSFGIVMWEVMS----FGERPYWDMSNH 217
STKc_PAK6 cd06659
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the ...
18-315 1.38e-20

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK6 may play a role in stress responses through its activation by the mitogen-activated protein kinase (MAPK) p38 and MAPK kinase 6 (MKK6) pathway. PAK6 is highly expressed in the brain. It is not required for viability, but together with PAK5, it is required for normal levels of locomotion and activity, and for learning and memory. Increased expression of PAK6 is found in primary and metastatic prostate cancer. PAK6 may play a role in the regulation of motility. PAK6 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270821 [Multi-domain]  Cd Length: 297  Bit Score: 90.43  E-value: 1.38e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  18 VFDVG-PRYTNLSY--IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQtycQRTL--REIKILLRFRHENIIgindiira 92
Cdd:cd06659  13 VVDQGdPRQLLENYvkIGEGSTGVVCIAREKHSGRQVAVKMMDLRKQQ---RRELlfNEVVIMRDYQHPNVV-------- 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  93 ptieQMKDVYIVQD----LME----TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLK 164
Cdd:cd06659  82 ----EMYKSYLVGEelwvLMEylqgGALTDIVSQTRLNEEQIATVCEAVLQALAYLHSQGVIHRDIKSDSILLTLDGRVK 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 165 ICDFGLARVADPDHDHTGFLteyVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPifpgKHYLDqlnhilgil 244
Cdd:cd06659 158 LSDFGFCAQISKDVPKRKSL---VGTPYWMAPEVISRCP-YGTEVDIWSLGIMVIEMVDGEP----PYFSD--------- 220
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 245 gSPSQedlnciinlkARNYLLSLPHknkvPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
Cdd:cd06659 221 -SPVQ----------AMKRLRDSPP----PKLKNSHKASPVLRDFLERMLVRDPQERATAQELLDHPFLLQ 276
STKc_DRAK2 cd14198
The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
121-313 1.55e-20

The catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 and DRAK2 (also called STK17B). Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. DRAK2 has been implicated in inducing or enhancing apoptosis in beta cells, fibroblasts, and lymphoid cells, where it is highly expressed. It is involved in regulating many immune processes including the germinal center (GC) reaction, responses to thymus-dependent antigens, activated T cell survival, memory T cell responses. It may be involved in the development of autoimmunity. The DRAK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271100 [Multi-domain]  Cd Length: 270  Bit Score: 89.98  E-value: 1.55e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 121 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTC---DLKICDFGLARVADpdhdHTGFLTEYVATRWYRAPE 197
Cdd:cd14198 107 VSENDIIRLIRQILEGVYYLHQNNIVHLDLKPQNILLSSIYplgDIKIVDFGMSRKIG----HACELREIMGTPEYLAPE 182
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 198 ImLNSKGYTKSIDIWSVGcILAEMLsnrpifpgkhyldqLNHILGILGSPSQEDLnciINLKARNYLLSlphknkvpwNR 277
Cdd:cd14198 183 I-LNYDPITTATDMWNIG-VIAYML--------------LTHESPFVGEDNQETF---LNISQVNVDYS---------EE 234
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 66932916 278 LFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14198 235 TFSSVSQLATDFIQKLLVKNPEKRPTAEICLSHSWL 270
STKc_CaMKK1 cd14200
Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; ...
24-313 1.59e-20

Catalytic domain of the Serine/Threonine kinase, Calmodulin Dependent Protein Kinase Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKKs are upstream kinases of the CaM kinase cascade that phosphorylate and activate CaMKI and CamKIV. They may also phosphorylate other substrates including PKB and AMP-activated protein kinase (AMPK). CaMKK1, also called CaMKK alpha, is involved in the regulation of glucose uptake in skeletal muscles, independently of AMPK and PKB activation. It also play roles in learning and memory. Studies on CaMKK1 knockout mice reveal deficits in fear conditioning. The CaMKK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271102 [Multi-domain]  Cd Length: 284  Bit Score: 90.01  E-value: 1.59e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-------------------------PFEHQTYCQRTLREIKILLRF 78
Cdd:cd14200   1 QYKLQSEIGKGSYGVVKLAYNESDDKYYAMKVLSkkkllkqygfprrppprgskaaqgeQAKPLAPLERVYQEIAILKKL 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  79 RHENIIGINDIIRAPTIEqmkDVYIVQDLMETD-LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL 157
Cdd:cd14200  81 DHVNIVKLIEVLDDPAED---NLYMVFDLLRKGpVMEVPSDKPFSEDQARLYFRDIVLGIEYLHYQKIVHRDIKPSNLLL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 158 NTTCDLKICDFGlarVADPDHDHTGFLTEYVATRWYRAPEIMLNS-KGYT-KSIDIWSVGCILAEMLSNRPIFpgkhyLD 235
Cdd:cd14200 158 GDDGHVKIADFG---VSNQFEGNDALLSSTAGTPAFMAPETLSDSgQSFSgKALDVWAMGVTLYCFVYGKCPF-----ID 229
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 236 QlnHILGilgspsqedlnciINLKARNYLLSLPHKnkvpwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14200 230 E--FILA-------------LHNKIKNKPVEFPEE---------PEISEELKDLILKMLDKNPETRITVPEIKVHPWV 283
STKc_PAK2 cd06655
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the ...
20-314 1.87e-20

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK2 plays a role in pro-apoptotic signaling. It is cleaved and activated by caspases leading to morphological changes during apoptosis. PAK2 is also activated in response to a variety of stresses including DNA damage, hyperosmolarity, serum starvation, and contact inhibition, and may play a role in coordinating the stress response. PAK2 also contributes to cancer cell invasion through a mechanism distinct from that of PAK1. It belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132986 [Multi-domain]  Cd Length: 296  Bit Score: 90.17  E-value: 1.87e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  20 DVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYCQRTLREIKILLRFRHENIIGINDiirapTIEQMK 99
Cdd:cd06655  16 DPKKKYTRYEKIGQGASGTVFTAIDVATGQEVAIKQIN-LQKQPKKELIINEILVMKELKNPNIVNFLD-----SFLVGD 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 DVYIVQD-LMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDH 178
Cdd:cd06655  90 ELFVVMEyLAGGSLTDVVTETCMDEAQIAAVCRECLQALEFLHANQVIHRDIKSDNVLLGMDGSVKLTDFGFCAQITPEQ 169
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 DHTGFLteyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLnHILGILGSPSQEDlnciinl 258
Cdd:cd06655 170 SKRSTM---VGTPYWMAPEV-VTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTPELQN------- 237
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 259 karnyllslPHKNKvPWNRlfpnadskalDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd06655 238 ---------PEKLS-PIFR----------DFLNRCLEMDVEKRGSAKELLQHPFLK 273
STKc_RIP cd13978
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze ...
31-251 2.04e-20

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP kinases serve as essential sensors of cellular stress. They are involved in regulating NF-kappaB and MAPK signaling, and are implicated in mediating cellular processes such as apoptosis, necroptosis, differentiation, and survival. RIP kinases contain a homologous N-terminal kinase domain and varying C-terminal domains. Higher vertebrates contain multiple RIP kinases, with mammals harboring at least five members. RIP1 and RIP2 harbor C-terminal domains from the Death domain (DD) superfamily while RIP4 contains ankyrin (ANK) repeats. RIP3 contain a RIP homotypic interaction motif (RHIM) that facilitates binding to RIP1. RIP1 and RIP3 are important in apoptosis and necroptosis, while RIP2 and RIP4 play roles in keratinocyte differentiation and inflammatory immune responses. The RIP subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270880 [Multi-domain]  Cd Length: 263  Bit Score: 89.43  E-value: 2.04e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIsPFEHQTYCQRT--LREIKILLRFRHENIIGINDIIRAPTieqmkDVYIVQDLM 108
Cdd:cd13978   1 LGSGGFGTVSKARHVSWFGMVAIKCL-HSSPNCIEERKalLKEAEKMERARHSYVLPLLGVCVERR-----SLGLVMEYM 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLL--KTQHLSNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGF 183
Cdd:cd13978  75 ENgSLKSLLerEIQDVPWSLRFRIIHEIALGMNFLHNMDppLLHHDLKPENILLDNHFHVKISDFGLSKLGMKSISANRR 154
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916 184 LT--EYVATRWYRAPEI--MLNSKGYTKSiDIWSVGCILAEMLSNRPIFPGKhyldqlNHILGILGSPSQED 251
Cdd:cd13978 155 RGteNLGGTPIYMAPEAfdDFNKKPTSKS-DVYSFAIVIWAVLTRKEPFENA------INPLLIMQIVSKGD 219
STKc_MAPKAPK cd14089
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated ...
31-312 2.09e-20

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase-activated protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of the MAPK-activated protein kinases MK2, MK3, MK5 (also called PRAK for p38-regulated/activated protein kinase), and related proteins. These proteins contain a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. In addition, MK2 and MK3 contain an N-terminal proline-rich region that can bind to SH3 domains. MK2 and MK3 are bonafide substrates for the MAPK p38, while MK5 plays a functional role in the p38 MAPK pathway although their direct interaction has been difficult to detect. MK2 and MK3 are closely related and show, thus far, indistinguishable substrate specificity, while MK5 shows a distinct spectrum of substrates. MK2 and MK3 are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK5 is a ubiquitous protein that is implicated in neuronal morphogenesis, cell migration, and tumor angiogenesis. It interacts with PKA, which induces cytoplasmic translocation of MK5. Its substrates includes p53, ERK3/4, Hsp27, and cytosolic phospholipase A2 (cPLA2). The MAPKAPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270991 [Multi-domain]  Cd Length: 263  Bit Score: 89.27  E-value: 2.09e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPfehqtyCQRTLREIKilLRFR---HENIIGINDIIrAPTIEQMKDVYIVQDL 107
Cdd:cd14089   9 LGLGINGKVLECFHKKTGEKFALKVLRD------NPKARREVE--LHWRasgCPHIVRIIDVY-ENTYQGRKCLLVVMEC 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 MET-DLYKLLK---TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT---CDLKICDFGLARVADPDHDh 180
Cdd:cd14089  80 MEGgELFSRIQeraDSAFTEREAAEIMRQIGSAVAHLHSMNIAHRDLKPENLLYSSKgpnAILKLTDFGFAKETTTKKS- 158
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 tgfLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHyldqlnhilGILGSPSQEDlnciinlKA 260
Cdd:cd14089 159 ---LQTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNH---------GLAISPGMKK-------RI 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 261 RNYLLSLPHKNkvpWNrlfpNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14089 219 RNGQYEFPNPE---WS----NVSEEAKDLIRGLLKTDPSERLTIEEVMNHPW 263
STKc_TSSK3-like cd14163
Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs ...
31-222 2.52e-20

Catalytic domain of testis-specific serine/threonine kinase 3 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TSSK proteins are almost exclusively expressed postmeiotically in the testis and play important roles in spermatogenesis and/or spermiogenesis. There are five mammalian TSSK proteins which show differences in their localization and timing of expression. TSSK3 has been reported to be expressed in the interstitial Leydig cells of adult testis. Its mRNA levels is low at birth, increases at puberty, and remains high throughout adulthood. The TSSK3-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271065 [Multi-domain]  Cd Length: 257  Bit Score: 88.89  E-value: 2.52e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKI----SPFEhqtYCQRTL-REIKILLRFRHENIIGINDIIRAPTieqmKDVYIVQ 105
Cdd:cd14163   8 IGEGTYSKVKEAFSKKHQRKVAIKIIdksgGPEE---FIQRFLpRELQIVERLDHKNIIHVYEMLESAD----GKIYLVM 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMET-DLYKLLKTQHLSNDHICYFLY-QILRGLKYIHSANVLHRDLKPSNLLLNTTcDLKICDFGLARVADPDHDHTGf 183
Cdd:cd14163  81 ELAEDgDVFDCVLHGGPLPEHRAKALFrQLVEAIRYCHGCGVAHRDLKCENALLQGF-TLKLTDFGFAKQLPKGGRELS- 158
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 66932916 184 lTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 222
Cdd:cd14163 159 -QTFCGSTAYAAPEVLQGVPHDSRKGDIWSMGVVLYVML 196
STKc_Titin cd14104
Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the ...
31-315 2.93e-20

Catalytic domain of the Giant Serine/Threonine Kinase Titin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Titin, also called connectin, is a muscle-specific elastic protein and is the largest known protein to date. It contains multiple immunoglobulin (Ig)-like and fibronectin type III (FN3) domains, and a single kinase domain near the C-terminus. It spans half of the sarcomere, the repeating contractile unit of striated muscle, and performs mechanical and catalytic functions. Titin contributes to the passive force generated when muscle is stretched during relaxation. Its kinase domain phosphorylates and regulates the muscle protein telethonin, which is required for sarcomere formation in differentiating myocytes. In addition, titin binds many sarcomere proteins and acts as a molecular scaffold for filament formation during myofibrillogenesis. The Titin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271006 [Multi-domain]  Cd Length: 277  Bit Score: 89.15  E-value: 2.93e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQTYCQRtlrEIKILLRFRHENIIGINDIIRAPtiEQMkdVYIVQDLME 109
Cdd:cd14104   8 LGRGQFGIVHRCVETSSKKTYMAKFVKvKGADQVLVKK---EISILNIARHRNILRLHESFESH--EEL--VMIFEFISG 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT--TCDLKICDFGLARVADPDHDhtgFLT 185
Cdd:cd14104  81 VDIFERITTArfELNEREIVSYVRQVCEALEFLHSKNIGHFDIRPENIIYCTrrGSYIKIIEFGQSRQLKPGDK---FRL 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 EYVATRWYrAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhyldqlnhilgiLGSPSQEDLNCIINLKarnyll 265
Cdd:cd14104 158 QYTSAEFY-APEV-HQHESVSTATDMWSLGCLVYVLLSGINPF---------------EAETNQQTIENIRNAE------ 214
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 266 slphknkvpWN---RLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
Cdd:cd14104 215 ---------YAfddEAFKNISIEALDFVDRLLVKERKSRMTAQEALNHPWLKQ 258
STKc_YPK1_like cd05585
Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the ...
128-315 3.08e-20

Catalytic domain of Yeast Protein Kinase 1-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of fungal proteins with similarity to the AGC STKs, Saccharomyces cerevisiae YPK1 and Schizosaccharomyces pombe Gad8p. YPK1 is required for cell growth and acts as a downstream kinase in the sphingolipid-mediated signaling pathway of yeast. It also plays a role in efficient endocytosis and in the maintenance of cell wall integrity. Gad8p is a downstream target of Tor1p, the fission yeast homolog of mTOR. It plays a role in cell growth and sexual development. The YPK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270737 [Multi-domain]  Cd Length: 313  Bit Score: 89.94  E-value: 3.08e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 128 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgflTEYVATRWYRAPEIMLnSKGYTK 207
Cdd:cd05585  98 FYTAELLCALECLHKFNVIYRDLKPENILLDYTGHIALCDFGLCKLNMKDDDKT---NTFCGTPEYLAPELLL-GHGYTK 173
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 208 SIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsQEDLnciinlkarnyllslphknkvpwnrLFP-NADSKA 286
Cdd:cd05585 174 AVDWWTLGVLLYEMLTGLPPFYDENTNEMYRKIL-------QEPL-------------------------RFPdGFDRDA 221
                       170       180       190
                ....*....|....*....|....*....|..
gi 66932916 287 LDLLDKMLTFNPHKRIEVEQALA---HPYLEQ 315
Cdd:cd05585 222 KDLLIGLLNRDPTKRLGYNGAQEiknHPFFDQ 253
STKc_Mos cd13979
Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze ...
27-232 3.82e-20

Catalytic domain of the Serine/Threonine kinase, Oocyte maturation factor Mos; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Mos (or c-Mos) is a germ-cell specific kinase that plays roles in both the release of primary arrest and the induction of secondary arrest in oocytes. It is expressed towards the end of meiosis I and is quickly degraded upon fertilization. It is a component of the cytostatic factor (CSF), which is responsible for metaphase II arrest. In addition, Mos activates a phoshorylation cascade that leads to the activation of the p34 subunit of MPF (mitosis-promoting factor or maturation promoting factor), a cyclin-dependent kinase that is responsible for the release of primary arrest in meiosis I. The Mos subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270881 [Multi-domain]  Cd Length: 265  Bit Score: 88.59  E-value: 3.82e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  27 NLSYIGEGAYGMVCSA-YDNVnkvRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPT-------IEQM 98
Cdd:cd13979   7 LQEPLGSGGFGSVYKAtYKGE---TVAVKIVRRRRKNRASRQSFWAELNAARLRHENIVRVLAAETGTDfaslgliIMEY 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLMETdLYKLLKTQHlsndHICYFLyQILRGLKYIHSANVLHRDLKPSNLLL--NTTCdlKICDFGLARVADP 176
Cdd:cd13979  84 CGNGTLQQLIYE-GSEPLPLAH----RILISL-DIARALRFCHSHGIVHLDVKPANILIseQGVC--KLCDFGCSVKLGE 155
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 177 DHDHTGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKH 232
Cdd:cd13979 156 GNEVGTPRSHIGGTYTYRAPEL-LKGERVTPKADIYSFGITLWQMLTRELPYAGLR 210
STKc_Nek6 cd08228
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
31-247 3.92e-20

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek6 is required for the transition from metaphase to anaphase. It also plays important roles in mitotic spindle formation and cytokinesis. Activated by Nek9 during mitosis, Nek6 phosphorylates Eg5, a kinesin that is important for spindle bipolarity. Nek6 localizes to spindle microtubules during metaphase and anaphase, and to the midbody during cytokinesis. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270865 [Multi-domain]  Cd Length: 268  Bit Score: 88.93  E-value: 3.92e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRT--LREIKILLRFRHENIIG-INDIIRAPTIEQMKDVYIVQDL 107
Cdd:cd08228  10 IGRGQFSEVYRATCLLDRKPVALKKVQIFEMMDAKARQdcVKEIDLLKQLNHPNVIKyLDSFIEDNELNIVLELADAGDL 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDhdhTGFLTEY 187
Cdd:cd08228  90 SQMIKYFKKQKRLIPERTVWKYFVQLCSAVEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFSSK---TTAAHSL 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 188 VATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLS----------------------NRPIFPGKHYLDQLNHILGILG 245
Cdd:cd08228 167 VGTPYYMSPE-RIHENGYNFKSDIWSLGCLLYEMAAlqspfygdkmnlfslcqkieqcDYPPLPTEHYSEKLRELVSMCI 245

                ..
gi 66932916 246 SP 247
Cdd:cd08228 246 YP 247
STKc_PLK2 cd14188
Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the ...
24-313 4.01e-20

Catalytic domain of the Serine/Threonine Kinase, Polo-like kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PLKs play important roles in cell cycle progression and in DNA damage responses. They regulate mitotic entry, mitotic exit, and cytokinesis. In general PLKs contain an N-terminal catalytic kinase domain and a C-terminal regulatory polo box domain (PBD), which is comprised by two bipartite polo-box motifs (or polo boxes) and is involved in protein interactions. There are five mammalian PLKs (PLK1-5) from distinct genes. PLK2, also called Snk (serum-inducible kinase), functions in G1 progression, S-phase arrest, and centriole duplication. Its gene is responsive to both growth factors and cellular stress, is a transcriptional target of p53, and activates a G2-M checkpoint. The PLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271090 [Multi-domain]  Cd Length: 255  Bit Score: 88.53  E-value: 4.01e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMvCSAYDNVNKVRVAIKKISPFE-----HQTycQRTLREIKILLRFRHENIIGINDiirapTIEQM 98
Cdd:cd14188   2 RYCRGKVLGKGGFAK-CYEMTDLTTNKVYAAKIIPHSrvskpHQR--EKIDKEIELHRILHHKHVVQFYH-----YFEDK 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLM-ETDLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADP 176
Cdd:cd14188  74 ENIYILLEYCsRRSMAHILKARKvLTEPEVRYYLRQIVSGLKYLHEQEILHRDLKLGNFFINENMELKVGDFGLAARLEP 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 177 DHDHTGFLteyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYldqlnhilgilgspsQEDLNCIi 256
Cdd:cd14188 154 LEHRRRTI---CGTPNYLSPEV-LNKQGHGCESDIWALGCVMYTMLLGRPPFETTNL---------------KETYRCI- 213
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 257 nlkaRNYLLSLPHKNKVPwnrlfpnadskALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14188 214 ----REARYSLPSSLLAP-----------AKHLIASMLSKNPEDRPSLDEIIRHDFF 255
STKc_Mnk cd14090
Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase ...
31-312 4.13e-20

Catalytic domain of the Serine/Threonine kinases, Mitogen-activated protein kinase signal-integrating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270992 [Multi-domain]  Cd Length: 289  Bit Score: 89.01  E-value: 4.13e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYcQRTLREIKILLRFR-HENIIGIndiiraptIEQMKD---VYIVQD 106
Cdd:cd14090  10 LGEGAYASVQTCINLYTGKEYAVKIIEKHPGHSR-SRVFREVETLHQCQgHPNILQL--------IEYFEDderFYLVFE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LME--TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL---LNTTCDLKICDFGLAR--------- 172
Cdd:cd14090  81 KMRggPLLSHIEKRVHFTEQEASLVVRDIASALDFLHDKGIAHRDLKPENILcesMDKVSPVKICDFDLGSgiklsstsm 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 --VADPDhdhtgfLTEYVATRWYRAPEIMLNSKG----YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDqLNHILGILGS 246
Cdd:cd14090 161 tpVTTPE------LLTPVGSAEYMAPEVVDAFVGealsYDKRCDLWSLGVILYIMLCGYPPFYGRCGED-CGWDRGEACQ 233
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 247 PSQEDL-NCIinlKARNYllSLPHKNkvpWNRLfpnaDSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14090 234 DCQELLfHSI---QEGEY--EFPEKE---WSHI----SAEAKDLISHLLVRDASQRYTAEQVLQHPW 288
PTKc_Wee1_fungi cd14052
Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the ...
24-311 4.34e-20

Catalytic domain of the Protein Tyrosine Kinases, Fungal Wee1 proteins; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of fungal Wee1 proteins, also called Swe1 in budding yeast and Mik1 in fission yeast. Yeast Wee1 is required to control cell size. Wee1 is a cell cycle checkpoint kinase that helps keep the cyclin-dependent kinase CDK1 in an inactive state through phosphorylation of an N-terminal tyr (Y15) residue. During the late G2 phase, CDK1 is activated and mitotic entry is promoted by the removal of this inhibitory phosphorylation by the phosphatase Cdc25. Although Wee1 is functionally a tyr kinase, it is more closely related to serine/threonine kinases (STKs). It contains a catalytic kinase domain sandwiched in between N- and C-terminal regulatory domains. It is regulated by phosphorylation and degradation, and its expression levels are also controlled by circadian clock proteins. The fungal Wee1 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, other PTKs, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270954 [Multi-domain]  Cd Length: 278  Bit Score: 88.63  E-value: 4.34e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRV-AIKKISP-FEHQTYCQRTLREIKILLRFR---HENIIGINDiirapTIEQM 98
Cdd:cd14052   1 RFANVELIGSGEFSQVYKVSERVPTGKVyAVKKLKPnYAGAKDRLRRLEEVSILRELTldgHDNIVQLID-----SWEYH 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLMET-DLYKLLKTQ----HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV 173
Cdd:cd14052  76 GHLYIQTELCENgSLDVFLSELgllgRLDEFRVWKILVELSLGLRFIHDHHFVHLDLKPANVLITFEGTLKIGDFGMATV 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 --ADPDHDHTGflteyvaTRWYRAPEImLNSKGYTKSIDIWSVGCILAEMlsnrpifpgkhyldQLNHILGILGSPSQE- 250
Cdd:cd14052 156 wpLIRGIEREG-------DREYIAPEI-LSEHMYDKPADIFSLGLILLEA--------------AANVVLPDNGDAWQKl 213
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 251 ---DLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALD-LLDKMLTFNPHKRIEVEQALAHP 311
Cdd:cd14052 214 rsgDLSDAPRLSSTDLHSASSPSSNPPPDPPNMPILSGSLDrVVRWMLSPEPDRRPTADDVLATP 278
STKc_PAK3 cd06656
Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine ...
18-314 4.51e-20

Catalytic domain of the Protein Serine/Threonine Kinase, p21-activated kinase 3; Serine/threonine kinases (STKs), p21-activated kinase (PAK) 3, catalytic (c) domain. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. PAKs from higher eukaryotes are classified into two groups (I and II), according to their biochemical and structural features. PAK3 belongs to group I. Group I PAKs contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAK3 is highly expressed in the brain. It is implicated in neuronal plasticity, synapse formation, dendritic spine morphogenesis, cell cycle progression, neuronal migration, and apoptosis. Inactivating mutations in the PAK3 gene cause X-linked non-syndromic mental retardation, the severity of which depends on the site of the mutation.


Pssm-ID: 132987 [Multi-domain]  Cd Length: 297  Bit Score: 89.01  E-value: 4.51e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYCQRTLREIKILlrfrHENiigindiiRAPTIEQ 97
Cdd:cd06656  14 VGDPKKKYTRFEKIGQGASGTVYTAIDIATGQEVAIKQMN-LQQQPKKELIINEILVM----REN--------KNPNIVN 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  98 MKDVYIVQD----LME----TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 169
Cdd:cd06656  81 YLDSYLVGDelwvVMEylagGSLTDVVTETCMDEGQIAAVCRECLQALDFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 170 LARVADPDHDHTGFLteyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLnHILGILGSPSQ 249
Cdd:cd06656 161 FCAQITPEQSKRSTM---VGTPYWMAPEV-VTRKAYGPKVDIWSLGIMAIEMVEGEPPYLNENPLRAL-YLIATNGTPEL 235
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 250 EDlnciinlkarnyllslPHKNKVPWNrlfpnadskalDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd06656 236 QN----------------PERLSAVFR-----------DFLNRCLEMDVDRRGSAKELLQHPFLK 273
STKc_PAK1 cd06654
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the ...
18-251 4.61e-20

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK1 is important in the regulation of many cellular processes including cytoskeletal dynamics, cell motility, growth, and proliferation. Although PAK1 has been regarded mainly as a cytosolic protein, recent reports indicate that PAK1 also exists in significant amounts in the nucleus, where it is involved in transcription modulation and in cell cycle regulatory events. PAK1 is also involved in transformation and tumorigenesis. Its overexpression, hyperactivation and increased nuclear accumulation is correlated to breast cancer invasiveness and progression. Nuclear accumulation is also linked to tamoxifen resistance in breast cancer cells. PAK1 belongs to the group I PAKs, which contain a PBD (p21-binding domain) overlapping with an AID (autoinhibitory domain), a C-terminal catalytic domain, SH3 binding sites and a non-classical SH3 binding site for PIX (PAK-interacting exchange factor). PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270820 [Multi-domain]  Cd Length: 296  Bit Score: 89.01  E-value: 4.61e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  18 VFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYCQRTLREIKILlrfrHENiigindiiRAPTIEQ 97
Cdd:cd06654  15 VGDPKKKYTRFEKIGQGASGTVYTAMDVATGQEVAIRQMN-LQQQPKKELIINEILVM----REN--------KNPNIVN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  98 MKDVYIVQD----LME----TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 169
Cdd:cd06654  82 YLDSYLVGDelwvVMEylagGSLTDVVTETCMDEGQIAAVCRECLQALEFLHSNQVIHRDIKSDNILLGMDGSVKLTDFG 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 170 LARVADPDHDHTGFLteyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLnHILGILGSPSQ 249
Cdd:cd06654 162 FCAQITPEQSKRSTM---VGTPYWMAPEV-VTRKAYGPKVDIWSLGIMAIEMIEGEPPYLNENPLRAL-YLIATNGTPEL 236

                ..
gi 66932916 250 ED 251
Cdd:cd06654 237 QN 238
STKc_obscurin_rpt2 cd14110
Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs ...
25-313 5.74e-20

Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Obscurin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Obscurin, approximately 800 kDa in size, is one of three giant proteins expressed in vetebrate striated muscle, together with titin and nebulin. It is a multidomain protein composed of tandem adhesion and signaling domains, including 49 immunoglobulin (Ig) and 2 fibronectin type III (FN3) domains at the N-terminus followed by a more complex region containing more Ig domains, a conserved SH3 domain near a RhoGEF and PH domains, non-modular regions, as well as IQ and phosphorylation motifs. The obscurin gene also encode two kinase domains, which are not expressed as part of the 800 kDa protein, but as a smaller, alternatively spliced product present mainly in the heart muscle, also called obscurin-MLCK. Obscurin is localized at the peripheries of Z-disks and M-lines, where it is able to communicate with the surrounding myoplasm. It interacts with diverse proteins including sAnk1, myosin, titin, and MyBP-C. It may act as a scaffold for the assembly of elements of the contractile apparatus. The obscurin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271012 [Multi-domain]  Cd Length: 257  Bit Score: 88.05  E-value: 5.74e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAiKKISPFeHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTieqmkDVYIV 104
Cdd:cd14110   5 YAFQTEINRGRFSVVRQCEEKRSGQMLA-AKIIPY-KPEDKQLVLREYQVLRRLSHPRIAQLHSAYLSPR-----HLVLI 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDH---- 178
Cdd:cd14110  78 EELCSGPelLYNLAERNSYSEAEVTDYLWQILSAVDYLHSRRILHLDLRSENMIITEKNLLKIVDLGNAQPFNQGKvlmt 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 DHTGfltEYVATrwyRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRpifpgkhyldqlnhilgilgSPSQEDLNCIINL 258
Cdd:cd14110 158 DKKG---DYVET---MAPEL-LEGQGAGPQTDIWAIGVTAFIMLSAD--------------------YPVSSDLNWERDR 210
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 259 KARnyllslphKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14110 211 NIR--------KGKVQLSRCYAGLSGGAVNFLKSTLCAKPWGRPTASECLQNPWL 257
PTKc_Syk_like cd05060
Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
31-223 7.16e-20

Catalytic domain of Spleen Tyrosine Kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Syk-like subfamily is composed of Syk, ZAP-70, Shark, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. They are involved in the signaling downstream of activated receptors (including B-cell, T-cell, and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. Syk is important in B-cell receptor signaling, while Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor signaling. Syk also plays a central role in Fc receptor-mediated phagocytosis in the adaptive immune system. Shark is exclusively expressed in ectodermally derived epithelia, and is localized preferentially to the apical surface of the epithelial cells, it may play a role in a signaling pathway for epithelial cell polarity. The Syk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270650 [Multi-domain]  Cd Length: 257  Bit Score: 87.79  E-value: 7.16e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAY---DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIeqmkdvYIVQDL 107
Cdd:cd05060   3 LGHGNFGSVRKGVylmKSGKEVEVAVKTLKQEHEKAGKKEFLREASVMAQLDHPCIVRLIGVCKGEPL------MLVMEL 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METD-LYK-LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDhtgflt 185
Cdd:cd05060  77 APLGpLLKyLKKRREIPVSDLKELAHQVAMGMAYLESKHFVHRDLAARNVLLVNRHQAKISDFGMSRALGAGSD------ 150
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 66932916 186 EYVAT-------RWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05060 151 YYRATtagrwplKWY-APECINYGKFSSKS-DVWSYGVTLWEAFS 193
STKc_Mnk2 cd14173
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
31-313 9.07e-20

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271075 [Multi-domain]  Cd Length: 288  Bit Score: 88.16  E-value: 9.07e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYcQRTLREIKILLRFR-HENIIGINDIIraptiEQMKDVYIVQDLME 109
Cdd:cd14173  10 LGEGAYARVQTCINLITNKEYAVKIIEKRPGHSR-SRVFREVEMLYQCQgHRNVLELIEFF-----EEEDKFYLVFEKMR 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 --TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL---NTTCDLKICDFGLARVADPDHDHTGFL 184
Cdd:cd14173  84 ggSILSHIHRRRHFNELEASVVVQDIASALDFLHNKGIAHRDLKPENILCehpNQVSPVKICDFDLGSGIKLNSDCSPIS 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 185 TEYVAT----RWYRAPEIM--LNSKG--YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDqlnhiLGI-LGSPSQEDLNCI 255
Cdd:cd14173 164 TPELLTpcgsAEYMAPEVVeaFNEEAsiYDKRCDLWSLGVILYIMLSGYPPFVGRCGSD-----CGWdRGEACPACQNML 238
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 256 -INLKARNYllSLPHKNkvpWNRLFPNADskalDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14173 239 fESIQEGKY--EFPEKD---WAHISCAAK----DLISKLLVRDAKQRLSAAQVLQHPWV 288
PTKc_Srm_Brk cd05148
Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal ...
31-223 9.84e-20

Catalytic domain of the Protein Tyrosine Kinases, Src-related kinase lacking C-terminal regulatory tyrosine and N-terminal myristylation sites (Srm) and Breast tumor kinase (Brk); PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Srm and Brk (also called protein tyrosine kinase 6) are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Brk has been found to be overexpressed in a majority of breast tumors. Src kinases in general contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr; they are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Srm and Brk however, lack the N-terminal myristylation sites. Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. The Srm/Brk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133248 [Multi-domain]  Cd Length: 261  Bit Score: 87.49  E-value: 9.84e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNvNKVRVAIKKISPfEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPtieqmKDVYIVQDLMET 110
Cdd:cd05148  14 LGSGYFGEVWEGLWK-NRVRVAIKILKS-DDLLKQQDFQKEVQALKRLRHKHLISLFAVCSVG-----EPVYIITELMEK 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 -DLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL--NTTCdlKICDFGLARVADPD----HDH 180
Cdd:cd05148  87 gSLLAFLRSpegQVLPVASLIDMACQVAEGMAYLEEQNSIHRDLAARNILVgeDLVC--KVADFGLARLIKEDvylsSDK 164
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 66932916 181 TgflteyVATRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05148 165 K------IPYKW-TAPEAASHGTFSTKS-DVWSFGILLYEMFT 199
STKc_p70S6K cd05584
Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs ...
28-343 1.02e-19

Catalytic domain of the Serine/Threonine Kinase, 70 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. p70S6K (or S6K) contains only one catalytic kinase domain, unlike p90 ribosomal S6 kinases (RSKs). It acts as a downstream effector of the STK mTOR (mammalian Target of Rapamycin) and plays a role in the regulation of the translation machinery during protein synthesis. p70S6K also plays a pivotal role in regulating cell size and glucose homeostasis. Its targets include S6, the translation initiation factor eIF3, and the insulin receptor substrate IRS-1, among others. Mammals contain two isoforms of p70S6K, named S6K1 and S6K2 (or S6K-beta). The p70S6K subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270736 [Multi-domain]  Cd Length: 323  Bit Score: 88.62  E-value: 1.02e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGmvcsaydnvnKVRVAIKKISPFEHQTYCQRTLREIKILlrfRHE----------NIIGIndiIRAPTIEQ 97
Cdd:cd05584   1 LKVLGKGGYG----------KVFQVRKTTGSDKGKIFAMKVLKKASIV---RNQkdtahtkaerNILEA---VKHPFIVD 64
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  98 M--------KDVYIVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDF 168
Cdd:cd05584  65 LhyafqtggKLYLILEYLSGGELFMHLEREGIfMEDTACFYLAEITLALGHLHSLGIIYRDLKPENILLDAQGHVKLTDF 144
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 169 GLA--RVADPDHDHTgflteYVATRWYRAPEIMLNSkGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgs 246
Cdd:cd05584 145 GLCkeSIHDGTVTHT-----FCGTIEYMAPEILTRS-GHGKAVDWWSLGALMYDMLTGAPPFTAENRKKTIDKI------ 212
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 247 psqedlnciinLKARnylLSLPhknkvpwnrlfPNADSKALDLLDKMLTFNPHKRIEVeqalahpyleqyyDPSD-EPIA 325
Cdd:cd05584 213 -----------LKGK---LNLP-----------PYLTNEARDLLKKLLKRNVSSRLGS-------------GPGDaEEIK 254
                       330
                ....*....|....*...
gi 66932916 326 EAPFKFDMELDDLPKEKL 343
Cdd:cd05584 255 AHPFFRHINWDDLLAKKV 272
STKc_MLCK cd14103
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the ...
31-313 1.12e-19

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module. MLCK2, MLCK3, and MLCK4 share a simpler domain architecture of a single kinase domain near the C-terminus and the absence of Ig-like or FN3 domains. The MLCK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271005 [Multi-domain]  Cd Length: 250  Bit Score: 86.90  E-value: 1.12e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVA---IKKISPFEHQtycqRTLREIKILLRFRHENIIGINDiirapTIEQMKDVYIVQDL 107
Cdd:cd14103   1 LGRGKFGTVYRCVEKATGKELAakfIKCRKAKDRE----DVRNEIEIMNQLRHPRLLQLYD-----AFETPREMVLVMEY 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 MET-DLYK--LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLL-LNTTCD-LKICDFGLARVADPDHD-HT 181
Cdd:cd14103  72 VAGgELFErvVDDDFELTERDCILFMRQICEGVQYMHKQGILHLDLKPENILcVSRTGNqIKIIDFGLARKYDPDKKlKV 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLT-EYVatrwyrAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIinlka 260
Cdd:cd14103 152 LFGTpEFV------APEV-VNYEPISYATDMWSVGVICYVLLSGLSPFMGDNDAETLANVTRAKWDFDDEAFDDI----- 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 261 rnyllslphknkvpwnrlfpnaDSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14103 220 ----------------------SDEAKDFISKLLVKDPRKRMSAAQCLQHPWL 250
STKc_PIM cd14005
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
24-313 1.28e-19

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 and three PIM2 isoforms as a result of alternative translation initiation sites, while there is only one PIM3 protein. Compound knockout mice deficient of all three PIM kinases that survive the perinatal period show a profound reduction in body size, indicating that PIMs are important for body growth. The PIM subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270907 [Multi-domain]  Cd Length: 255  Bit Score: 86.91  E-value: 1.28e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIsPFEHQTYC------QRTLREIKILLR---FRHENIIGINDIIRAPt 94
Cdd:cd14005   1 QYEVGDLLGKGGFGTVYSGVRIRDGLPVAVKFV-PKSRVTEWamingpVPVPLEIALLLKaskPGVPGVIRLLDWYERP- 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  95 ieqmkDVYIVqdLME-----TDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICD 167
Cdd:cd14005  79 -----DGFLL--IMErpepcQDLFDFITERgALSENLARIIFRQVVEAVRHCHQRGVLHRDIKDENLLINlRTGEVKLID 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 168 FGLARVAdpdhdHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhyldqlNHILGILgsp 247
Cdd:cd14005 152 FGCGALL-----KDSVYTDFDGTRVYSPPEWIRHGRYHGRPATVWSLGILLYDMLCGDIPF---------ENDEQIL--- 214
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 248 sqedlnciinlkaRNYLLSLPHKNKvpwnrlfpnadsKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14005 215 -------------RGNVLFRPRLSK------------ECCDLISRCLQFDPSKRPSLEQILSHPWF 255
STKc_IRAK4 cd14158
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; ...
19-228 1.42e-19

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK4 plays a critical role in NFkB activation by its interaction with MyD88, which acts as a scaffold that enables IRAK4 to phosphorylate and activate IRAK1 and/or IRAK2. It also plays an important role in type I IFN production induced by TLR7/8/9. The IRAK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271060 [Multi-domain]  Cd Length: 288  Bit Score: 87.55  E-value: 1.42e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  19 FDVGPRYTNLSYIGEGAYGMVCSAYdnVNKVRVAIKKISPFEHQTYCQRTL---REIKILLRFRHENIIGINDIIRAPTI 95
Cdd:cd14158  11 FDERPISVGGNKLGEGGFGVVFKGY--INDKNVAVKKLAAMVDISTEDLTKqfeQEIQVMAKCQHENLVELLGYSCDGPQ 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  96 EQMKDVYIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARvAD 175
Cdd:cd14158  89 LCLVYTYMPNGSLLDRLACLNDTPPLSWHMRCKIAQGTANGINYLHENNHIHRDIKSANILLDETFVPKISDFGLAR-AS 167
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 176 PDHDHTGFLTEYVATRWYRAPEIMLNSkgYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd14158 168 EKFSQTIMTERIVGTTAYMAPEALRGE--ITPKSDIFSFGVVLLEIITGLPPV 218
PTKc_Lyn cd05072
Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the ...
31-230 2.22e-19

Catalytic domain of the Protein Tyrosine Kinase, Lyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lyn is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lyn is expressed in B lymphocytes and myeloid cells. It exhibits both positive and negative regulatory roles in B cell receptor (BCR) signaling. Lyn, as well as Fyn and Blk, promotes B cell activation by phosphorylating ITAMs (immunoreceptor tyr activation motifs) in CD19 and in Ig components of BCR. It negatively regulates signaling by its unique ability to phosphorylate ITIMs (immunoreceptor tyr inhibition motifs) in cell surface receptors like CD22 and CD5. Lyn also plays an important role in G-CSF receptor signaling by phosphorylating a variety of adaptor molecules. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lyn subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270657 [Multi-domain]  Cd Length: 272  Bit Score: 86.63  E-value: 2.22e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNvNKVRVAIKKISPFEHQTycQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLM-E 109
Cdd:cd05072  15 LGAGQFGEVWMGYYN-NSTKVAVKTLKPGTMSV--QAFLEEANLMKTLQHDKLVRLYAVV-----TKEEPIYIITEYMaK 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKTQHLSN---DHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpDHDHTGFLTE 186
Cdd:cd05072  87 GSLLDFLKSDEGGKvllPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIE-DNEYTAREGA 165
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 66932916 187 YVATRWyRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPI-FPG 230
Cdd:cd05072 166 KFPIKW-TAPE-AINFGSFTIKSDVWSFGILLYEIVTYGKIpYPG 208
STKc_16 cd13986
Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the ...
24-310 2.28e-19

Catalytic domain of Serine/Threonine Kinase 16; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK16 is associated with many names including Myristylated and Palmitylated Serine/threonine Kinase 1 (MPSK1), Kinase related to cerevisiae and thaliana (Krct), and Protein Kinase expressed in day 12 fetal liver (PKL12). It is widely expressed in mammals with highest levels found in liver, testis, and kidney. It is localized in the Golgi but is translocated to the nucleus upon disorganization of the Golgi. STK16 is constitutively active and is capable of phosphorylating itself and other substrates. It may be involved in regulating stromal-epithelial interactions during mammary gland ductal morphogenesis. It may also function as a transcriptional co-activator of type-C natriuretic peptide and VEGF. The STK16 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270888 [Multi-domain]  Cd Length: 282  Bit Score: 86.97  E-value: 2.28e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKIS-PF-EHQtycQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDV 101
Cdd:cd13986   1 RYRIQRLLGEGGFSFVYLVEDLSTGRLYALKKILcHSkEDV---KEAMREIENYRLFNHPNILRLLDSQIVKEAGGKKEV 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIV---------QDLMETdlyKLLKTQHLSNDHICYFLYQILRGLKYIHSAN---VLHRDLKPSNLLLNTTCDLKICDFG 169
Cdd:cd13986  78 YLLlpyykrgslQDEIER---RLVKGTFFPEDRILHIFLGICRGLKAMHEPElvpYAHRDIKPGNVLLSEDDEPILMDLG 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 170 LARVA--------------DPDHDHtgflteyvATRWYRAPEiMLNSKGY---TKSIDIWSVGCIL-AEMLSNRPifpgk 231
Cdd:cd13986 155 SMNPArieiegrrealalqDWAAEH--------CTMPYRAPE-LFDVKSHctiDEKTDIWSLGCTLyALMYGESP----- 220
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 232 hyldqLNHILGILGSpsqedlnciINLKARNYLLSLPHKNKVPwnrlfpnadSKALDLLDKMLTFNPHKRIEVEQALAH 310
Cdd:cd13986 221 -----FERIFQKGDS---------LALAVLSGNYSFPDNSRYS---------EELHQLVKSMLVVNPAERPSIDDLLSR 276
STKc_DRAK1 cd14197
Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related ...
132-313 2.30e-19

Catalytic domain of the Serine/Threonine Kinase, Death-associated protein kinase-Related Apoptosis-inducing protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. DRAKs were named based on their similarity (around 50% identity) to the kinase domain of DAPKs. They contain an N-terminal kinase domain and a C-terminal regulatory domain. Vertebrates contain two subfamily members, DRAK1 (also called STK17A) and DRAK2. Both DRAKs are localized to the nucleus, autophosphorylate themselves, and phosphorylate myosin light chain as a substrate. Rabbit DRAK1 has been shown to induce apoptosis in osteoclasts and overexpressio of human DRAK1 induces apoptosis in cultured fibroblast cells. DRAK1 may be involved in apoptotic signaling. The DRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271099 [Multi-domain]  Cd Length: 271  Bit Score: 86.53  E-value: 2.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTC---DLKICDFGLARVADPDHDhtgfLTEYVATRWYRAPEImLNSKGYTKS 208
Cdd:cd14197 119 QILEGVSFLHNNNVVHLDLKPQNILLTSESplgDIKIVDFGLSRILKNSEE----LREIMGTPEYVAPEI-LSYEPISTA 193
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 209 IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIinlkarnyllslphknkvpwnrlfpnaDSKALD 288
Cdd:cd14197 194 TDMWSIGVLAYVMLTGISPFLGDDKQETFLNISQMNVSYSEEEFEHL---------------------------SESAID 246
                       170       180
                ....*....|....*....|....*
gi 66932916 289 LLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14197 247 FIKTLLIKKPENRATAEDCLKHPWL 271
STKc_PKA cd14209
Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze ...
25-228 2.58e-19

Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The inactive PKA holoenzyme is a heterotetramer composed of two phosphorylated and active catalytic subunits with a dimer of regulatory (R) subunits. Activation is achieved through the binding of the important second messenger cAMP to the R subunits, which leads to the dissociation of PKA into the R dimer and two active subunits. PKA is present ubiquitously in cells and interacts with many different downstream targets. It plays a role in the regulation of diverse processes such as growth, development, memory, metabolism, gene expression, immunity, and lipolysis. The PKA subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271111 [Multi-domain]  Cd Length: 290  Bit Score: 86.69  E-value: 2.58e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMV----------CSAYDNVNKVRVAikKISPFEHqtycqrTLREIKILLRFRHENIIGINDiirapt 94
Cdd:cd14209   3 FDRIKTLGTGSFGRVmlvrhketgnYYAMKILDKQKVV--KLKQVEH------TLNEKRILQAINFPFLVKLEY------ 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  95 ieQMKD---VYIVQDLMET-DLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 169
Cdd:cd14209  69 --SFKDnsnLYMVMEYVPGgEMFSHLrRIGRFSEPHARFYAAQIVLAFEYLHSLDLIYRDLKPENLLIDQQGYIKVTDFG 146
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 170 LARVADpdhDHTGFLteyVATRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd14209 147 FAKRVK---GRTWTL---CGTPEYLAPEIIL-SKGYNKAVDWWALGVLIYEMAAGYPPF 198
STKc_MLCK2 cd14190
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze ...
31-313 3.21e-19

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK2 (or MYLK2) phosphorylates myosin regulatory light chain and controls the contraction of skeletal muscles. MLCK2 contains a single kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site. The MLCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271092 [Multi-domain]  Cd Length: 261  Bit Score: 86.13  E-value: 3.21e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVA---IKKISPFEHQTycqrTLREIKILLRFRHENIIGINDIIRAPtieqmKDVYIVQDL 107
Cdd:cd14190  12 LGGGKFGKVHTCTEKRTGLKLAakvINKQNSKDKEM----VLLEIQVMNQLNHRNLIQLYEAIETP-----NEIVLFMEY 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 MET-DLYKLL--KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL-NTTCDL-KICDFGLARVADPDHDhtg 182
Cdd:cd14190  83 VEGgELFERIvdEDYHLTEVDAMVFVRQICEGIQFMHQMRVLHLDLKPENILCvNRTGHQvKIIDFGLARRYNPREK--- 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 183 fLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhyldqlnhilgiLGSPSQEDLNciiNLKARN 262
Cdd:cd14190 160 -LKVNFGTPEFLSPEV-VNYDQVSFPTDMWSMGVITYMLLSGLSPF---------------LGDDDTETLN---NVLMGN 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 263 YLLSlphknkvpwNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14190 220 WYFD---------EETFEHVSDEAKDFVSNLIIKERSARMSATQCLKHPWL 261
STKc_WNK cd13983
Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze ...
31-225 3.91e-19

Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNKs comprise a subfamily of STKs with an unusual placement of a catalytic lysine relative to all other protein kinases. They are critical in regulating ion balance and are thus, important components in the control of blood pressure. They are also involved in cell signaling, survival, proliferation, and organ development. WNKs are activated by hyperosmotic or low-chloride hypotonic stress and they function upstream of SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. There are four vertebrate WNKs which show varying expression patterns. WNK1 and WNK2 are widely expressed while WNK3 and WNK4 show a more restricted expression pattern. Because mutations in human WNK1 and WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension (due to increased sodium reabsorption) and hyperkalemia (due to impaired renal potassium secretion), there are more studies conducted on these two proteins, compared to WNK2 and WNK3. The WNK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270885 [Multi-domain]  Cd Length: 258  Bit Score: 85.74  E-value: 3.91e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVA-----IKKISPFEHQtycqRTLREIKILLRFRHENIIGINDIIRAPTIEQMkdVYIVQ 105
Cdd:cd13983   9 LGRGSFKTVYRAFDTEEGIEVAwneikLRKLPKAERQ----RFKQEIEILKSLKHPNIIKFYDSWESKSKKEV--IFITE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 dLMETDLYK--LLKTQHLSNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLN-TTCDLKICDFGLARVADPDHDH 180
Cdd:cd13983  83 -LMTSGTLKqyLKRFKRLKLKVIKSWCRQILEGLNYLHTRDppIIHRDLKCDNIFINgNTGEVKIGDLGLATLLRQSFAK 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 66932916 181 TgflteYVATRWYRAPEIMLNskGYTKSIDIWSVGCILAEMLSNR 225
Cdd:cd13983 162 S-----VIGTPEFMAPEMYEE--HYDEKVDIYAFGMCLLEMATGE 199
PTKc_Csk_like cd05039
Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
31-223 4.26e-19

Catalytic domain of C-terminal Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of Csk, Chk, and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. They negatively regulate the activity of Src kinases that are anchored to the plasma membrane. To inhibit Src kinases, Csk and Chk are translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Chk inhibit Src kinases using a noncatalytic mechanism by simply binding to them. As negative regulators of Src kinases, Csk and Chk play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. The Csk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270635 [Multi-domain]  Cd Length: 256  Bit Score: 85.48  E-value: 4.26e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSA-YDNvNKVrvAIKKISpfEHQTYCQRTLREIKILLRFRHENI---IGIndiiraptIEQMKDVYIVQD 106
Cdd:cd05039  14 IGKGEFGDVMLGdYRG-QKV--AVKCLK--DDSTAAQAFLAEASVMTTLRHPNLvqlLGV--------VLEGNGLYIVTE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LMET-DLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG 182
Cdd:cd05039  81 YMAKgSLVDYLRSrgrAVITRKDQLGFALDVCEGMEYLESKKFVHRDLAARNVLVSEDNVAKVSDFGLAKEASSNQDGGK 160
                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 66932916 183 FlteyvATRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05039 161 L-----PIKW-TAPEALREKKFSTKS-DVWSFGILLWEIYS 194
STKc_PAK5 cd06658
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the ...
27-320 5.30e-19

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK5 is mainly expressed in the brain. It is not required for viability, but together with PAK6, it is required for normal levels of locomotion and activity, and for learning and memory. PAK5 cooperates with Inca (induced in neural crest by AP2) in the regulation of cell adhesion and cytoskeletal organization in the embryo and in neural crest cells during craniofacial development. PAK5 may also play a role in controlling the signaling of Raf-1, an effector of Ras, at the mitochondria. PAK5 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132989 [Multi-domain]  Cd Length: 292  Bit Score: 85.86  E-value: 5.30e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  27 NLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYCQRTLREIKILLRFRHENIIginDIIRAPTIEQmkDVYIVQD 106
Cdd:cd06658  26 SFIKIGEGSTGIVCIATEKHTGKQVAVKKMD-LRKQQRRELLFNEVVIMRDYHHENVV---DMYNSYLVGD--ELWVVME 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LMETD-LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLt 185
Cdd:cd06658 100 FLEGGaLTDIVTHTRMNEEQIATVCLSVLRALSYLHNQGVIHRDIKSDSILLTSDGRIKLSDFGFCAQVSKEVPKRKSL- 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 eyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILgSPSQEDLnciinlkarnyll 265
Cdd:cd06658 179 --VGTPYWMAPEV-ISRLPYGTEVDIWSLGIMVIEMIDGEPPYFNEPPLQAMRRIRDNL-PPRVKDS------------- 241
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 266 slpHKnkvpwnrlfpnADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPS 320
Cdd:cd06658 242 ---HK-----------VSSVLRGFLDLMLVREPSQRATAQELLQHPFLKLAGPPS 282
STKc_SRPK1 cd14216
Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 1; STKs ...
24-313 5.33e-19

Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPK1 binds with high affinity the alternative splicing factor, SRSF1 (serine/arginine-rich splicing factor 1), and regiospecifically phosphorylates 10-12 serines in its RS domain. It plays a role in the regulation of pre-mRNA splicing, chromatin structure, and germ cell development. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271118 [Multi-domain]  Cd Length: 349  Bit Score: 87.01  E-value: 5.33e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHqtYCQRTLREIKILLRFRHENIigiNDIIRAPTIEQMKDVYI 103
Cdd:cd14216  11 RYHVIRKLGWGHFSTVWLSWDIQGKRFVAMKVVKSAEH--YTETALDEIKLLKSVRNSDP---NDPNREMVVQLLDDFKI 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 -------VQDLMETDLYKLLK------TQHLSNDHICYFLYQILRGLKYIHS-ANVLHRDLKPSNLLLNTT--------- 160
Cdd:cd14216  86 sgvngthICMVFEVLGHHLLKwiiksnYQGLPLPCVKKIIRQVLQGLDYLHTkCRIIHTDIKPENILLSVNeqyirrlaa 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 161 ---------------------CDLKICDFGLARVAdpdHDHtgfLTEYVATRWYRAPEIMLNSkGYTKSIDIWSVGCILA 219
Cdd:cd14216 166 eatewqrnflvnplepknaekLKVKIADLGNACWV---HKH---FTEDIQTRQYRSLEVLIGS-GYNTPADIWSTACMAF 238
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 220 EMLSNRPIF---PGKHYLDQLNHILGILGSPSQEDLNCIINLKARNYLLS----LPHKNKV-PWNRL--------FPNAD 283
Cdd:cd14216 239 ELATGDYLFephSGEDYSRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTkkgdLKHITKLkPWGLFevlvekyeWSQEE 318
                       330       340       350
                ....*....|....*....|....*....|.
gi 66932916 284 SKAL-DLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14216 319 AAGFtDFLLPMLELIPEKRATAAECLRHPWL 349
STKc_SnRK2-3 cd14665
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
24-222 6.25e-19

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2, group 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271135 [Multi-domain]  Cd Length: 257  Bit Score: 85.04  E-value: 6.25e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTycQRTLREIKILLRFRHENIIGINDIIRAPTieqmkDVYI 103
Cdd:cd14665   1 RYELVKDIGSGNFGVARLMRDKQTKELVAVKYIERGEKID--ENVQREIINHRSLRHPNIVRFKEVILTPT-----HLAI 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMET-DLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN--TTCDLKICDFGLARvADPDHD 179
Cdd:cd14665  74 VMEYAAGgELFeRICNAGRFSEDEARFFFQQLISGVSYCHSMQICHRDLKLENTLLDgsPAPRLKICDFGYSK-SSVLHS 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 66932916 180 HTgflTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 222
Cdd:cd14665 153 QP---KSTVGTPAYIAPEVLLKKEYDGKIADVWSCGVTLYVML 192
STKc_SGK1 cd05602
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
28-327 8.64e-19

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK1 is ubiquitously expressed and is under transcriptional control of numerous stimuli including cell stress (cell shrinkage), serum, hormones (gluco- and mineralocorticoids), gonadotropins, growth factors, interleukin-6, and other cytokines. It plays roles in sodium retention and potassium elimination in the kidney, nutrient transport, salt sensitivity, memory consolidation, and cardiac repolarization. A common SGK1 variant is associated with increased blood pressure and body weight. SGK1 may also contribute to tumor growth, neurodegeneration, fibrosing disease, and ischemia. The SGK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270753 [Multi-domain]  Cd Length: 339  Bit Score: 86.22  E-value: 8.64e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGMVCSAYDNVNKVRVAIKKIS--PFEHQTYCQRTLREIKILLR-FRHENIIGINDiirapTIEQMKDVYIV 104
Cdd:cd05602  12 LKVIGKGSFGKVLLARHKSDEKFYAVKVLQkkAILKKKEEKHIMSERNVLLKnVKHPFLVGLHF-----SFQTTDKLYFV 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARvadPDHDHTG 182
Cdd:cd05602  87 LDYINGGelFYHLQRERCFLEPRARFYAAEIASALGYLHSLNIVYRDLKPENILLDSQGHIVLTDFGLCK---ENIEPNG 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 183 FLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHilgILGSPSQEDLNciINLKARN 262
Cdd:cd05602 164 TTSTFCGTPEYLAPEV-LHKQPYDRTVDWWCLGAVLYEMLYGLPPFYSRNTAEMYDN---ILNKPLQLKPN--ITNSARH 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 263 YLLSLPHKNKVpwNRLFPNADSKAL------------DLLDKMLT--FNPHkrieveqaLAHPYLEQYYDP--SDEPIAE 326
Cdd:cd05602 238 LLEGLLQKDRT--KRLGAKDDFTEIknhiffspinwdDLINKKITppFNPN--------VSGPNDLRHFDPefTDEPVPN 307

                .
gi 66932916 327 A 327
Cdd:cd05602 308 S 308
STKc_IKK cd13989
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
31-229 9.05e-19

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The IKK complex functions as a master regulator of Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. It is composed of two kinases, IKKalpha and IKKbeta, and the regulatory subunit IKKgamma or NEMO (NF-kB Essential MOdulator). IKKs facilitate the release of NF-kB dimers from an inactive state, allowing them to migrate to the nucleus where they regulate gene transcription. There are two IKK pathways that regulate NF-kB signaling, called the classical (involving IKKbeta and NEMO) and non-canonical (involving IKKalpha) pathways. The classical pathway regulates the majority of genes activated by NF-kB. The IKK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270891 [Multi-domain]  Cd Length: 289  Bit Score: 85.19  E-value: 9.05e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKK----ISPFEHQtyCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQd 106
Cdd:cd13989   1 LGSGGFGYVTLWKHQDTGEYVAIKKcrqeLSPSDKN--RERWCLEVQIMKKLNHPNVVSARDVPPELEKLSPNDLPLLA- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 lME----TDLYKLLKTQH----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFGLARvad 175
Cdd:cd13989  78 -MEycsgGDLRKVLNQPEnccgLKESEVRTLLSDISSAISYLHENRIIHRDLKPENIVLQQGGGrviYKLIDLGYAK--- 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 176 pDHDHTGFLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSN-RPIFP 229
Cdd:cd13989 154 -ELDQGSLCTSFVGTLQYLAPELFESKK-YTCTVDYWSFGTLAFECITGyRPFLP 206
STKc_PASK cd14004
Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs ...
25-313 9.71e-19

Catalytic domain of the Serine/Threonine kinase, Per-ARNT-Sim (PAS) domain Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PASK (or PASKIN) is a nutrient and energy sensor and thus, plays an important role in maintaining cellular energy homeostasis. It coordinates the utilization of glucose in response to metabolic demand. It contains an N-terminal PAS domain which directly interacts and inhibits a C-terminal catalytic kinase domain. The PAS domain serves as a sensory module for different environmental signals such as light, redox state, and various metabolites. Binding of ligands to the PAS domain causes structural changes which leads to kinase activation and the phosphorylation of substrates to trigger the appropriate cellular response. The PASK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270906 [Multi-domain]  Cd Length: 256  Bit Score: 84.36  E-value: 9.71e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYC---QRTLREIKI-------LLRFRHENIIGINDIIrapt 94
Cdd:cd14004   2 YTILKEMGEGAYGQVNLAIYKSKGKEVVIKFIFKERILVDTwvrDRKLGTVPLeihildtLNKRSHPNIVKLLDFF---- 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  95 iEQMKDVYIVqdlMET-----DLYKLLKTQHLSNDHIC-YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDF 168
Cdd:cd14004  78 -EDDEFYYLV---MEKhgsgmDLFDFIERKPNMDEKEAkYIFRQVADAVKHLHDQGIVHRDIKDENVILDGNGTIKLIDF 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 169 GLARvadpdHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMlsnrpIFPGKHYLDqlnhILGILGSPS 248
Cdd:cd14004 154 GSAA-----YIKSGPFDTFVGTIDYAAPEVLRGNPYGGKEQDIWALGVLLYTL-----VFKENPFYN----IEEILEADL 219
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 249 QedlnciinlkarnyllslphknkvpwnrlFPNADSK-ALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14004 220 R-----------------------------IPYAVSEdLIDLISRMLNRDVGDRPTIEELLTDPWL 256
STKc_PRKX_like cd05612
Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of ...
31-231 1.25e-18

Catalytic domain of PRKX-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this group include human PRKX (X chromosome-encoded protein kinase), Drosophila DC2, and similar proteins. PRKX is present in many tissues including fetal and adult brain, kidney, and lung. The PRKX gene is located in the Xp22.3 subregion and has a homolog called PRKY on the Y chromosome. An abnormal interchange between PRKX aand PRKY leads to the sex reversal disorder of XX males and XY females. PRKX is implicated in granulocyte/macrophage lineage differentiation, renal cell epithelial migration, and tubular morphogenesis in the developing kidney. The PRKX-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270763 [Multi-domain]  Cd Length: 292  Bit Score: 84.79  E-value: 1.25e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFE----HQTycQRTLREIKILLRFRHENIIGIndiiraptIEQMKDVYIVQD 106
Cdd:cd05612   9 IGTGTFGRVHLVRDRISEHYYALKVMAIPEvirlKQE--QHVHNEKRVLKEVSHPFIIRL--------FWTEHDQRFLYM 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LME----TDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAdpdHDHT 181
Cdd:cd05612  79 LMEyvpgGELFSYLRNSgRFSNSTGLFYASEIVCALEYLHSKEIVYRDLKPENILLDKEGHIKLTDFGFAKKL---RDRT 155
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLteyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 231
Cdd:cd05612 156 WTL---CGTPEYLAPEV-IQSKGHNKAVDWWALGILIYEMLVGYPPFFDD 201
STKc_MSK2_C cd14180
C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
31-305 1.33e-18

C-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271082 [Multi-domain]  Cd Length: 309  Bit Score: 85.31  E-value: 1.33e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISpfehQTYCQRTLREIKIL-LRFRHENIIGINDIIRaptiEQMKdVYIVQDLME 109
Cdd:cd14180  14 LGEGSFSVCRKCRHRQSGQEYAVKIIS----RRMEANTQREVAALrLCQSHPNIVALHEVLH----DQYH-TYLVMELLR 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFGLARVADPDHD--HTG 182
Cdd:cd14180  85 GGelLDRIKKKARFSESEASQLMRSLVSAVSFMHEAGVVHRDLKPENILYADESDgavLKVIDFGFARLRPQGSRplQTP 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 183 FLTEYvatrwYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHyldqlnhilGILGSPSQEDLNCiinlKARN 262
Cdd:cd14180 165 CFTLQ-----YAAPE-LFSNQGYDESCDLWSLGVILYTMLSGQVPFQSKR---------GKMFHNHAADIMH----KIKE 225
                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 66932916 263 YLLSLPHKnkvPWNrlfpNADSKALDLLDKMLTFNPHKRIEVE 305
Cdd:cd14180 226 GDFSLEGE---AWK----GVSEEAKDLVRGLLTVDPAKRLKLS 261
STKc_SPEG_rpt1 cd14108
Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle ...
31-313 1.34e-18

Catalytic kinase domain, first repeat, of Giant Serine/Threonine Kinase Striated muscle preferentially expressed protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The Striated muscle preferentially expressed gene (SPEG) generates 4 different isoforms through alternative promoter use and splicing in a tissue-specific manner: SPEGalpha and SPEGbeta are expressed in cardiac and skeletal striated muscle; Aortic Preferentially Expressed Protein-1 (APEG-1) is expressed in vascular smooth muscle; and Brain preferentially expressed gene (BPEG) is found in the brain and aorta. SPEG proteins have mutliple immunoglobulin (Ig), 2 fibronectin type III (FN3), and two kinase domains. They are necessary for cardiac development and survival. The SPEG subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271010 [Multi-domain]  Cd Length: 255  Bit Score: 84.18  E-value: 1.34e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRtlREIKILLRFRHENIIGINDiirapTIEQMKDVYIVQDL-ME 109
Cdd:cd14108  10 IGRGAFSYLRRVKEKSSDLSFAAKFIPVRAKKKTSAR--RELALLAELDHKSIVRFHD-----AFEKRRVVIIVTELcHE 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL--NTTCDLKICDFGLARVADPDHDHtgfLTEY 187
Cdd:cd14108  83 ELLERITKRPTVCESEVRSYMRQLLEGIEYLHQNDVLHLDLKPENLLMadQKTDQVRICDFGNAQELTPNEPQ---YCKY 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 188 vATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqedlnciinlkaRNYLLSL 267
Cdd:cd14108 160 -GTPEFVAPEI-VNQSPVSKVTDIWPVGVIAYLCLTGISPFVGENDRTTLMNI--------------------RNYNVAF 217
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 66932916 268 PHknkvpwnRLFPNADSKALDLLDKMLTfNPHKRIEVEQALAHPYL 313
Cdd:cd14108 218 EE-------SMFKDLCREAKGFIIKVLV-SDRLRPDAEETLEHPWF 255
STKc_HUNK cd14070
Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase ...
31-313 1.50e-18

Catalytic domain of the Serine/Threonine Kinase, Hormonally up-regulated Neu-associated kinase (also called MAK-V); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. HUNK/MAK-V was identified from a mammary tumor in an MMTV-neu transgenic mouse. It is required for the metastasis of c-myc-induced mammary tumors, but is not necessary for c-myc-induced primary tumor formation or normal development. It is required for HER2/neu-induced tumor formation and maintenance of the cells' tumorigenic phenotype. It is over-expressed in aggressive subsets of ovary, colon, and breast carcinomas. HUNK interacts with synaptopodin, and may also play a role in synaptic plasticity. The HUNK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270972 [Multi-domain]  Cd Length: 262  Bit Score: 84.10  E-value: 1.50e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISP--FEHQTYCQRTL-REIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDL 107
Cdd:cd14070  10 LGEGSFAKVREGLHAVTGEKVAIKVIDKkkAKKDSYVTKNLrREGRIQQMIRHPNITQLLDIL-----ETENSYYLVMEL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLT 185
Cdd:cd14070  85 CPGGnlMHRIYDKKRLEEREARRYIRQLVSAVEHLHRAGVVHRDLKIENLLLDENDNIKLIDFGLSNCAGILGYSDPFST 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 EyVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYldqlnhilgilgspsqedlnciiNLKARNYLL 265
Cdd:cd14070 165 Q-CGSPAYAAPE-LLARKKYGPKVDVWSIGVNMYAMLTGTLPFTVEPF-----------------------SLRALHQKM 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 66932916 266 SLPHKNKVPwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14070 220 VDKEMNPLP-----TDLSPGAISFLRSLLEPDPLKRPNIKQALANRWL 262
STKc_MELK cd14078
Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; ...
31-313 1.56e-18

Catalytic domain of the Serine/Threonine Kinase, Maternal Embryonic Leucine zipper Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MELK is a cell cycle dependent protein which functions in cytokinesis, cell cycle, apoptosis, cell proliferation, and mRNA processing. It is found upregulated in many types of cancer cells, playing an indispensable role in cancer cell survival. It makes an attractive target in the design of inhibitors for use in the treatment of a wide range of human cancer. The MELK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270980 [Multi-domain]  Cd Length: 257  Bit Score: 83.97  E-value: 1.56e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVqdlME- 109
Cdd:cd14078  11 IGSGGFAKVKLATHILTGEKVAIKIMDKKALGDDLPRVKTEIEALKNLSHQHICRLYHVI-----ETDNKIFMV---LEy 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 ---TDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLarVADPDHDHTGFLT 185
Cdd:cd14078  83 cpgGELFDYIVAKdRLSEDEARVFFRQIVSAVAYVHSQGYAHRDLKPENLLLDEDQNLKLIDFGL--CAKPKGGMDHHLE 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 EYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSnrpifpgkhyldqlnhilGILgsPSQEDLNCIINLKARNYLL 265
Cdd:cd14078 161 TCCGSPAYAAPELIQGKPYIGSEADVWSMGVLLYALLC------------------GFL--PFDDDNVMALYRKIQSGKY 220
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 66932916 266 SLPHknkvpWnrlfpnADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14078 221 EEPE-----W------LSPSSKLLLDQMLQVDPKKRITVKELLNHPWV 257
STKc_STK25 cd06642
Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); ...
25-232 1.77e-18

Catalytic domain of Serine/Threonine Kinase 25 (also called Yeast Sps1/Ste20-related kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK25 is also called Ste20/oxidant stress response kinase 1 (SOK1) or yeast Sps1/Ste20-related kinase 1 (YSK1). It is localized in the Golgi apparatus through its interaction with the Golgi matrix protein GM130. It may be involved in the regulation of cell migration and polarization. STK25 binds and phosphorylates CCM3 (cerebral cavernous malformation 3), also called PCD10 (programmed cell death 10), and may play a role in apoptosis. Human STK25 is a candidate gene responsible for pseudopseudohypoparathyroidism (PPHP), a disease that shares features with the Albright hereditary osteodystrophy (AHO) phenotype. The STK25 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270810 [Multi-domain]  Cd Length: 277  Bit Score: 84.34  E-value: 1.77e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGIndiiRAPTIEQMKDVYIV 104
Cdd:cd06642   6 FTKLERIGKGSFGEVYKGIDNRTKEVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYITRY----YGSYLKGTKLWIIM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-RVADPDHDHTGF 183
Cdd:cd06642  82 EYLGGGSALDLLKPGPLEETYIATILREILKGLDYLHSERKIHRDIKAANVLLSEQGDVKLADFGVAgQLTDTQIKRNTF 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 184 lteyVATRWYRAPEIMLNSkGYTKSIDIWSVGCILAEMLSNRPIFPGKH 232
Cdd:cd06642 162 ----VGTPFWMAPEVIKQS-AYDFKADIWSLGITAIELAKGEPPNSDLH 205
PKc_CLK2 cd14215
Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2; Dual-specificity ...
24-313 1.85e-18

Catalytic domain of the Dual-specificity protein kinase, CDC-like kinase 2; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. CLK2 plays a role in hepatic insulin signaling and glucose metabolism. It is induced by the insulin/Akt pathway as part of the hepatic refeeding reponse, and it directly phosphorylates the SR domain of PGC-1alpha, which results in decreased gluconeogenic gene expression and glucose output. CLKs are involved in the phosphorylation and regulation of serine/arginine-rich (SR) proteins, which play a crucial role in pre-mRNA splicing by directing splice site selection. SR proteins are phosphorylated first by SR protein kinases (SRPKs) at the N-terminus, which leads to its assembly into nuclear speckles where splicing factors are stored. CLKs phosphorylate the C-terminal part of SR proteins, causing the nuclear speckles to dissolve and splicing factors to be recruited at sites of active transcription. Based on a conserved "EHLAMMERILG" signature motif which may be crucial for substrate specificity, CLKs are also referred to as LAMMER kinases. CLKs autophosphorylate at tyrosine residues and phosphorylate their substrates exclusively on serine/threonine residues. The CLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271117 [Multi-domain]  Cd Length: 330  Bit Score: 85.07  E-value: 1.85e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNV-NKVRVAIKKISPFEhqTYCQRTLREIKILLRFRHENIIGINDIIraptieQMKDVY 102
Cdd:cd14215  13 RYEIVSTLGEGTFGRVVQCIDHRrGGARVALKIIKNVE--KYKEAARLEINVLEKINEKDPENKNLCV------QMFDWF 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 -------IVQDLMETDLYKLLKTQHL---SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT------------ 160
Cdd:cd14215  85 dyhghmcISFELLGLSTFDFLKENNYlpyPIHQVRHMAFQVCQAVKFLHDNKLTHTDLKPENILFVNSdyeltynlekkr 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 161 -------CDLKICDFGLARVadpDHDHTgflTEYVATRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPIFP---G 230
Cdd:cd14215 165 dersvksTAIRVVDFGSATF---DHEHH---STIVSTRHYRAPEVIL-ELGWSQPCDVWSIGCIIFEYYVGFTLFQthdN 237
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 231 KHYLDQLNHILG------ILGSPSQE-----DLNCIINLKARNYLlslpHKNKVPWNR-LFPNADS--KALDLLDKMLTF 296
Cdd:cd14215 238 REHLAMMERILGpipsrmIRKTRKQKyfyhgRLDWDENTSAGRYV----RENCKPLRRyLTSEAEEhhQLFDLIESMLEY 313
                       330
                ....*....|....*..
gi 66932916 297 NPHKRIEVEQALAHPYL 313
Cdd:cd14215 314 EPSKRLTLAAALKHPFF 330
STKc_MAP3K8 cd13995
Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) ...
30-313 1.99e-18

Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K8 is also called Tumor progression locus 2 (Tpl2) or Cancer Osaka thyroid (Cot), and was first identified as a proto-oncogene in T-cell lymphoma induced by MoMuL virus and in breast carcinoma induced by MMTV. Activated MAP3K8 induces various MAPK pathways including Extracellular Regulated Kinase (ERK) 1/2, c-Jun N-terminal kinase (JNK), and p38. It plays a pivotal role in innate immunity, linking Toll-like receptors to the production of TNF and the activation of ERK in macrophages. It is also required in interleukin-1beta production and is critical in host defense against Gram-positive bacteria. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K8 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270897 [Multi-domain]  Cd Length: 256  Bit Score: 83.52  E-value: 1.99e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  30 YIGEGAYGMVCSAYDNVNKVRVAIKKIsPFEHqtycqRTLREIKILLRFRHENIIginDIIRAPTIEQMKDVYIVQDLME 109
Cdd:cd13995  11 FIPRGAFGKVYLAQDTKTKKRMACKLI-PVEQ-----FKPSDVEIQACFRHENIA---ELYGALLWEETVHLFMEAGEGG 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLkICDFGLARVADPDhdhTGFLTEYVA 189
Cdd:cd13995  82 SVLEKLESCGPMREFEIIWVTKHVLKGLDFLHSKNIIHHDIKPSNIVFMSTKAV-LVDFGLSVQMTED---VYVPKDLRG 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 190 TRWYRAPEIMLnSKGYTKSIDIWSVGCILAEMLSNRPI----FPGKHYldqlnhilgilgsPSqedlnciinlkarnyLL 265
Cdd:cd13995 158 TEIYMSPEVIL-CRGHNTKADIYSLGATIIHMQTGSPPwvrrYPRSAY-------------PS---------------YL 208
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 66932916 266 SLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd13995 209 YIIHKQAPPLEDIAQDCSPAMRELLEAALERNPNHRSSAAELLKHEAL 256
STKc_NIK cd13991
Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs ...
31-223 1.99e-18

Catalytic domain of the Serine/Threonine kinase, NF-kappaB Inducing Kinase (NIK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIK, also called mitogen activated protein kinase kinase kinase 14 (MAP3K14), phosphorylates and activates Inhibitor of NF-KappaB Kinase (IKK) alpha, which is a regulator of NF-kB proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. NIK is essential in the IKKalpha-mediated non-canonical NF-kB signaling pathway, in which IKKalpha processes the IkB-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus where it regulates gene transcription. NIK also plays an important role in Toll-like receptor 7/9 signaling cascades. The NIK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270893 [Multi-domain]  Cd Length: 268  Bit Score: 84.10  E-value: 1.99e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISpfehqtycqrtlreikiLLRFRHENIiGINDIIRAPTIEQMKD-------VYI 103
Cdd:cd13991  14 IGRGSFGEVHRMEDKQTGFQCAVKKVR-----------------LEVFRAEEL-MACAGLTSPRVVPLYGavregpwVNI 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMET-DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTC-DLKICDFGLARVADPD-HD 179
Cdd:cd13991  76 FMDLKEGgSLGQLIKEQgCLPEDRALHYLGQALEGLEYLHSRKILHGDVKADNVLLSSDGsDAFLCDFGHAECLDPDgLG 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 66932916 180 HTGFLTEYV-ATRWYRAPEIMLNSKGYTKsIDIWSVGCILAEMLS 223
Cdd:cd13991 156 KSLFTGDYIpGTETHMAPEVVLGKPCDAK-VDVWSSCCMMLHMLN 199
STKc_SLK cd06643
Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer ...
31-327 2.05e-18

Catalytic domain of the Serine/Threonine Kinase, Ste20-Like Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SLK promotes apoptosis through apoptosis signal-regulating kinase 1 (ASK1) and the mitogen-activated protein kinase (MAPK) p38. It acts as a MAPK kinase kinase by phosphorylating ASK1, resulting in the phosphorylation of p38. SLK also plays a role in mediating actin reorganization. It is part of a microtubule-associated complex that is targeted at adhesion sites, and is required in focal adhesion turnover and in regulating cell migration. The SLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270811 [Multi-domain]  Cd Length: 283  Bit Score: 84.31  E-value: 2.05e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKI---SPFEHQTYcqrtLREIKILLRFRHENIIGINDIIRAPTieqmkDVYIVQDL 107
Cdd:cd06643  13 LGDGAFGKVYKAQNKETGILAAAKVIdtkSEEELEDY----MVEIDILASCDHPNIVKLLDAFYYEN-----NLWILIEF 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 ME---TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGlarVADPDHDHTGFL 184
Cdd:cd06643  84 CAggaVDAVMLELERPLTEPQIRVVCKQTLEALVYLHENKIIHRDLKAGNILFTLDGDIKLADFG---VSAKNTRTLQRR 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 185 TEYVATRWYRAPEIML----NSKGYTKSIDIWSVGCILAEMLSnrpIFPGKHYLDQLNHILGILGS--PSqedlnciinl 258
Cdd:cd06643 161 DSFIGTPYWMAPEVVMcetsKDRPYDYKADVWSLGVTLIEMAQ---IEPPHHELNPMRVLLKIAKSepPT---------- 227
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 259 karnylLSLPHKnkvpWNRLFPnadskalDLLDKMLTFNPHKRIEVEQALAHPYLEQYYD--PSDEPIAEA 327
Cdd:cd06643 228 ------LAQPSR----WSPEFK-------DFLRKCLEKNVDARWTTSQLLQHPFVSVLVSnkPLRELIAEA 281
STKc_CaMKI_delta cd14168
Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase ...
15-313 2.20e-18

Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type I delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CaMKs are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). In vertebrates, there are four CaMKI proteins encoded by different genes (alpha, beta, gamma, and delta), each producing at least one variant. CaMKs contain an N-terminal catalytic domain and a C-terminal regulatory domain that harbors a CaM binding site. CaMKI proteins are monomeric and they play pivotal roles in the nervous system, including long-term potentiation, dendritic arborization, neurite outgrowth, and the formation of spines, synapses, and axons. In addition, they may be involved in osteoclast differentiation and bone resorption. The CaMKI-delta subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271070 [Multi-domain]  Cd Length: 301  Bit Score: 84.33  E-value: 2.20e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  15 RGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPt 94
Cdd:cd14168   2 KKQVEDIKKIFEFKEVLGTGAFSEVVLAEERATGKLFAVKCIPKKALKGKESSIENEIAVLRKIKHENIVALEDIYESP- 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  95 ieqmKDVYIVQDLMET-DLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFG 169
Cdd:cd14168  81 ----NHLYLVMQLVSGgELFdRIVEKGFYTEKDASTLIRQVLDAVYYLHRMGIVHRDLKPENLLYFSQDEeskIMISDFG 156
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 170 LARVadpdhDHTG-FLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgsps 248
Cdd:cd14168 157 LSKM-----EGKGdVMSTACGTPGYVAPEV-LAQKPYSKAVDCWSIGVIAYILLCGYPPFYDENDSKLFEQI-------- 222
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 249 qedlnciinLKArNYLLSLPHknkvpWNRLfpnADSkALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14168 223 ---------LKA-DYEFDSPY-----WDDI---SDS-AKDFIRNLMEKDPNKRYTCEQALRHPWI 268
STKc_MARK cd14072
Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; ...
24-306 2.25e-18

Catalytic domain of the Serine/Threonine Kinases, MAP/microtubule affinity-regulating kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MARKs, also called Partitioning-defective 1 (Par1) proteins, function as regulators of diverse cellular processes in nematodes, Drosophila, yeast, and vertebrates. They are involved in embryogenesis, epithelial cell polarization, cell signaling, and neuronal differentiation. MARKs phosphorylate tau and related microtubule-associated proteins (MAPs), and regulates microtubule-based intracellular transport. Vertebrates contain four isoforms, namely MARK1 (or Par1c), MARK2 (or Par1b), MARK3 (Par1a), and MARK4 (or MARKL1). Known substrates of MARKs include the cell cycle-regulating phosphatase Cdc25, tyrosine phosphatase PTPH1, MAPK scaffolding protein KSR1, class IIa histone deacetylases, and plakophilin 2. The MARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270974 [Multi-domain]  Cd Length: 253  Bit Score: 83.34  E-value: 2.25e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE-HQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVY 102
Cdd:cd14072   1 NYRLLKTIGKGNFAKVKLARHVLTGREVAIKIIDKTQlNPSSLQKLFREVRIMKILNHPNIVKLFEVI-----ETEKTLY 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLM---ETDLYKLLKTQHLSNDHICYFlYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHD 179
Cdd:cd14072  76 LVMEYAsggEVFDYLVAHGRMKEKEARAKF-RQIVSAVQYCHQKRIVHRDLKAENLLLDADMNIKIADFGFSNEFTPGNK 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 htgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDqlnhilgilgspsqedlnciinLK 259
Cdd:cd14072 155 ----LDTFCGSPPYAAPELFQGKKYDGPEVDVWSLGVILYTLVSGSLPFDGQNLKE----------------------LR 208
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 260 ARnyllSLPHKNKVPWnrlFPNADSKalDLLDKMLTFNPHKRIEVEQ 306
Cdd:cd14072 209 ER----VLRGKYRIPF---YMSTDCE--NLLKKFLVLNPSKRGTLEQ 246
STKc_IKK_alpha cd14039
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
31-226 2.56e-18

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKalpha is involved in the non-canonical or alternative pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The non-canonical pathway functions in cells lacking NEMO (NF-kB Essential MOdulator) and IKKbeta. It is induced by a subset of TNFR family members including CD40, RANK, and B cell-activating factor receptor. IKKalpha processes the Inhibitor of NF-kB (IkB)-like C-terminus of NF-kB2/p100 to produce p52, allowing the p52/RelB dimer to migrate to the nucleus. This pathway is dependent on NIK (NF-kB Inducing Kinase) which phosphorylates and activates IKKalpha. The IKKalpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270941 [Multi-domain]  Cd Length: 289  Bit Score: 83.81  E-value: 2.56e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIK----KISPFEHQTYCqrtlREIKILLRFRHENIIGINDIiraPtiEQMKdvYIVQD 106
Cdd:cd14039   1 LGTGGFGNVCLYQNQETGEKIAIKscrlELSVKNKDRWC----HEIQIMKKLNHPNVVKACDV---P--EEMN--FLVND 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 L----ME----TDLYKLLKTQH----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL---NTTCDLKICDFGLA 171
Cdd:cd14039  70 VpllaMEycsgGDLRKLLNKPEnccgLKESQVLSLLSDIGSGIQYLHENKIIHRDLKPENIVLqeiNGKIVHKIIDLGYA 149
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 172 RvadpDHDHTGFLTEYVATRWYRAPEIMLNsKGYTKSIDIWSVGCILAEMLSN-RP 226
Cdd:cd14039 150 K----DLDQGSLCTSFVGTLQYLAPELFEN-KSYTVTVDYWSFGTMVFECIAGfRP 200
PTKc_Hck cd05073
Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the ...
31-230 3.57e-18

Catalytic domain of the Protein Tyrosine Kinase, Hematopoietic cell kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Hck is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Hck is present in myeloid and lymphoid cells that play a role in the development of cancer. It may be important in the oncogenic signaling of the protein Tel-Abl, which induces a chronic myelogenous leukemia (CML)-like disease. Hck also acts as a negative regulator of G-CSF-induced proliferation of granulocytic precursors, suggesting a possible role in the development of acute myeloid leukemia (AML). In addition, Hck is essential in regulating the degranulation of polymorphonuclear leukocytes. Genetic polymorphisms affect the expression level of Hck, which affects PMN mediator release and influences the development of chronic obstructive pulmonary disease (COPD). Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Hck subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270658 [Multi-domain]  Cd Length: 265  Bit Score: 83.15  E-value: 3.57e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNvNKVRVAIKKISPFEHQTycQRTLREIKILLRFRHENIIGINDII-RAPtieqmkdVYIVQDLME 109
Cdd:cd05073  19 LGAGQFGEVWMATYN-KHTKVAVKTMKPGSMSV--EAFLAEANVMKTLQHDKLVKLHAVVtKEP-------IYIITEFMA 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 T-DLYKLLKTQHLSNDHI---CYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpDHDHTGFLT 185
Cdd:cd05073  89 KgSLLDFLKSDEGSKQPLpklIDFSAQIAEGMAFIEQRNYIHRDLRAANILVSASLVCKIADFGLARVIE-DNEYTAREG 167
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 66932916 186 EYVATRWyRAPEiMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPG 230
Cdd:cd05073 168 AKFPIKW-TAPE-AINFGSFTIKSDVWSFGILLMEIVTyGRIPYPG 211
STKc_IKK_beta cd14038
Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase ...
31-301 5.86e-18

Catalytic domain of the Serine/Threonine kinase, Inhibitor of Nuclear Factor-KappaB Kinase (IKK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IKKbeta is involved in the classical pathway of regulating Nuclear Factor-KappaB (NF-kB) proteins, a family of transcription factors which are critical in many cellular functions including inflammatory responses, immune development, cell survival, and cell proliferation, among others. The classical pathway regulates the majority of genes activated by NF-kB including those encoding cytokines, chemokines, leukocyte adhesion molecules, and anti-apoptotic factors. It involves NEMO (NF-kB Essential MOdulator)- and IKKbeta-dependent phosphorylation and degradation of the Inhibitor of NF-kB (IkB), which liberates NF-kB dimers (typified by the p50-p65 heterodimer) from an inactive IkB/dimeric NF-kB complex, enabling them to migrate to the nucleus where they regulate gene transcription. The IKKbeta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270940 [Multi-domain]  Cd Length: 290  Bit Score: 83.09  E-value: 5.86e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKK----ISPFEHQTYCQrtlrEIKILLRFRHENIIGINDIiraPtiEQMKDVyIVQD 106
Cdd:cd14038   2 LGTGGFGNVLRWINQETGEQVAIKQcrqeLSPKNRERWCL----EIQIMKRLNHPNVVAARDV---P--EGLQKL-APND 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 L----ME----TDLYKLLKTQH----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL---KICDFGLA 171
Cdd:cd14038  72 LpllaMEycqgGDLRKYLNQFEnccgLREGAILTLLSDISSALRYLHENRIIHRDLKPENIVLQQGEQRlihKIIDLGYA 151
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 172 RvadpDHDHTGFLTEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSN-RPIFPG-----KHYLDQLNHILGILG 245
Cdd:cd14038 152 K----ELDQGSLCTSFVGTLQYLAPE-LLEQQKYTVTVDYWSFGTLAFECITGfRPFLPNwqpvqWHGKVRQKSNEDIVV 226
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 246 SpsqEDLNCIINLKArnyllSLPHKNKVpwNRLFPNADSKALDLldkMLTFNPHKR 301
Cdd:cd14038 227 Y---EDLTGAVKFSS-----VLPTPNNL--NGILAGKLERWLQC---MLMWHPRQR 269
STKc_MEKK3 cd06651
Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular ...
31-264 6.70e-18

Catalytic domain of the Serine/Threonine Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MEKK3 is a MAPK kinase kinase (MAPKKK or MKKK), that phosphorylates and activates the MAPK kinase MEK5 (or MKK5), which in turn phosphorylates and activates ERK5. The ERK5 cascade plays roles in promoting cell proliferation, differentiation, neuronal survival, and neuroprotection. MEKK3 plays an essential role in embryonic angiogenesis and early heart development. In addition, MEKK3 is involved in interleukin-1 receptor and Toll-like receptor 4 signaling. It is also a specific regulator of the proinflammatory cytokines IL-6 and GM-CSF in some immune cells. MEKK3 also regulates calcineurin, which plays a critical role in T cell activation, apoptosis, skeletal myocyte differentiation, and cardiac hypertrophy. The MEKK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270817 [Multi-domain]  Cd Length: 271  Bit Score: 82.44  E-value: 6.70e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIS--PFEHQTYCQRTLRE--IKILLRFRHENIIGINDIIRAptiEQMKDVYIVQD 106
Cdd:cd06651  15 LGQGAFGRVYLCYDVDTGRELAAKQVQfdPESPETSKEVSALEceIQLLKNLQHERIVQYYGCLRD---RAEKTLTIFME 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LMETDLYK--LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-RVADPDHDHTGf 183
Cdd:cd06651  92 YMPGGSVKdqLKAYGALTESVTRKYTRQILEGMSYLHSNMIVHRDIKGANILRDSAGNVKLGDFGASkRLQTICMSGTG- 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPifPGKHYlDQLNHILGILGSPSQEDLNCIINLKARNY 263
Cdd:cd06651 171 IRSVTGTPYWMSPEV-ISGEGYGRKADVWSLGCTVVEMLTEKP--PWAEY-EAMAAIFKIATQPTNPQLPSHISEHARDF 246

                .
gi 66932916 264 L 264
Cdd:cd06651 247 L 247
STKc_SNRK cd14074
Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the ...
31-313 6.97e-18

Catalytic domain of the Serine/Threonine Kinase, SNF1-related kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SNRK is a kinase highly expressed in testis and brain that is found inactive in cells that lack the LKB1 tumour suppressor protein kinase. The regulatory subunits STRAD and MO25 are required for LKB1 to activate SNRK. The SNRK mRNA is increased 3-fold when granule neurons are cultured in low potassium, and may thus play a role in the survival responses in these cells. In some vertebrates, a second SNRK gene (snrkb or snrk-1) has been sequenced and/or identified. Snrk-1 is expressed specifically in embryonic zebrafish vasculature; it plays an essential role in angioblast differentiation, maintenance, and migration. The SNRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270976 [Multi-domain]  Cd Length: 258  Bit Score: 82.08  E-value: 6.97e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTL-REIKILLRFRHENIIGINDIIRAPTieqmkDVYIVQDLME 109
Cdd:cd14074  11 LGRGHFAVVKLARHVFTGEKVAVKVIDKTKLDDVSKAHLfQEVRCMKLVQHPNVVRLYEVIDTQT-----KLYLILELGD 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 T-DLYKLLkTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDL-KICDFGLARVADPDHDhtgfL 184
Cdd:cd14074  86 GgDMYDYI-MKHengLNEDLARKYFRQIVSAISYCHKLHVVHRDLKPENVVFFEKQGLvKLTDFGFSNKFQPGEK----L 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 185 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqedLNCiinlkarnyl 264
Cdd:cd14074 161 ETSCGSLAYSAPEILLGDEYDAPAVDIWSLGVILYMLVCGQPPFQEANDSETLTMI-----------MDC---------- 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 265 lslphKNKVPwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14074 220 -----KYTVP-----AHVSPECKDLIRRMLIRDPKKRASLEEIENHPWL 258
PTKc_Src cd05071
Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the ...
31-237 7.08e-18

Catalytic domain of the Protein Tyrosine Kinase, Src; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Src (or c-Src) is a cytoplasmic (or non-receptor) PTK, containing an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region with a conserved tyr. It is activated by autophosphorylation at the tyr kinase domain, and is negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). c-Src is the vertebrate homolog of the oncogenic protein (v-Src) from Rous sarcoma virus. Together with other Src subfamily proteins, it is involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. Src also play a role in regulating cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. Elevated levels of Src kinase activity have been reported in a variety of human cancers. Several inhibitors of Src have been developed as anti-cancer drugs. Src is also implicated in acute inflammatory responses and osteoclast function. The Src subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270656 [Multi-domain]  Cd Length: 277  Bit Score: 82.43  E-value: 7.08e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNvNKVRVAIKKISPFEHQTycQRTLREIKILLRFRHENIIGINDIIRAPTIeqmkdvYIVQDLMET 110
Cdd:cd05071  17 LGQGCFGEVWMGTWN-GTTRVAIKTLKPGTMSP--EAFLQEAQVMKKLRHEKLVQLYAVVSEEPI------YIVTEYMSK 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 -DLYKLLKTQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpDHDHTGFLTE 186
Cdd:cd05071  88 gSLLDFLKGEmgkYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIE-DNEYTARQGA 166
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 187 YVATRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLSN-RPIFPG---KHYLDQL 237
Cdd:cd05071 167 KFPIKW-TAPEAALYGRFTIKS-DVWSFGILLTELTTKgRVPYPGmvnREVLDQV 219
STKc_NAK_like cd14037
Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze ...
30-218 7.90e-18

Catalytic domain of Numb-Associated Kinase (NAK)-like Serine/Threonine kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of Drosophila melanogaster NAK, human BMP-2-inducible protein kinase (BMP2K or BIKe) and similar vertebrate proteins, as well as the Saccharomyces cerevisiae proteins Prk1, Actin-regulating kinase 1 (Ark1), and Akl1. NAK was the first characterized member of this subfamily. It plays a role in asymmetric cell division through its association with Numb. It also regulates the localization of Dlg, a protein essential for septate junction formation. BMP2K contains a nuclear localization signal and a kinase domain that is capable of phosphorylating itself and myelin basic protein. The expression of the BMP2K gene is increase during BMP-2-induced osteoblast differentiation. It may function to control the rate of differentiation. Prk1, Ark1, and Akl1 comprise a subfamily of yeast proteins that are important regulators of the actin cytoskeleton and endocytosis. They share an N-terminal kinase domain but no significant homology in other regions of their sequences. The NAK-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270939 [Multi-domain]  Cd Length: 277  Bit Score: 82.33  E-value: 7.90e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  30 YIGEGAYGMVCSAYDNVNKVRVAIKKIS-PFEHQ-TYCQRtlrEIKILLRFR-HENIIGINDIIRAPTIEQMKDVYI--- 103
Cdd:cd14037  10 YLAEGGFAHVYLVKTSNGGNRAALKRVYvNDEHDlNVCKR---EIEIMKRLSgHKNIVGYIDSSANRSGNGVYEVLLlme 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 ------VQDLMETDLykllkTQHLSNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNTTCDLKICDFGLARVAD 175
Cdd:cd14037  87 yckgggVIDLMNQRL-----QTGLTESEILKIFCDVCEAVAAMHYLKppLIHRDLKVENVLISDSGNYKLCDFGSATTKI 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 176 PD---HDHTGFLTEYVA---TRWYRAPEiMLN---SKGYTKSIDIWSVGCIL 218
Cdd:cd14037 162 LPpqtKQGVTYVEEDIKkytTLQYRAPE-MIDlyrGKPITEKSDIWALGCLL 212
PTKc_Src_Fyn_like cd14203
Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
31-237 8.35e-18

Catalytic domain of a subset of Src kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes a subset of Src-like PTKs including Src, Fyn, Yrk, and Yes, which are all widely expressed. Yrk has been detected only in chickens. It is primarily found in neuronal and epithelial cells and in macrophages. It may play a role in inflammation and in response to injury. Src (or c-Src) proteins are cytoplasmic (or non-receptor) PTKs which are anchored to the plasma membrane. They contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). Src proteins are involved in signaling pathways that regulate cytokine and growth factor responses, cytoskeleton dynamics, cell proliferation, survival, and differentiation. They were identified as the first proto-oncogene products, and they regulate cell adhesion, invasion, and motility in cancer cells and tumor vasculature, contributing to cancer progression and metastasis. They are also implicated in acute inflammatory responses and osteoclast function. The Src/Fyn-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271105 [Multi-domain]  Cd Length: 248  Bit Score: 81.89  E-value: 8.35e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNkVRVAIKKISPFEHQTycQRTLREIKILLRFRHENIIGINDIIRAPTIeqmkdvYIVQDLM-E 109
Cdd:cd14203   3 LGQGCFGEVWMGTWNGT-TKVAIKTLKPGTMSP--EAFLEEAQIMKKLRHDKLVQLYAVVSEEPI------YIVTEFMsK 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpDHDHTGFLTE 186
Cdd:cd14203  74 GSLLDFLKDgegKYLKLPQLVDMAAQIASGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIE-DNEYTARQGA 152
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 187 YVATRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLSN-RPIFPG---KHYLDQL 237
Cdd:cd14203 153 KFPIKW-TAPEAALYGRFTIKS-DVWSFGILLTELVTKgRVPYPGmnnREVLEQV 205
STKc_MST4 cd06640
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs ...
25-240 1.15e-17

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST4 is sometimes referred to as MASK (MST3 and SOK1-related kinase). It plays a role in mitogen-activated protein kinase (MAPK) signaling during cytoskeletal rearrangement, morphogenesis, and apoptosis. It influences cell growth and transformation by modulating the extracellular signal-regulated kinase (ERK) pathway. MST4 may also play a role in tumor formation and progression. It localizes in the Golgi apparatus by interacting with the Golgi matrix protein GM130 and may play a role in cell migration. The MST4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132971 [Multi-domain]  Cd Length: 277  Bit Score: 82.02  E-value: 1.15e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGIndiiRAPTIEQMKDVYIV 104
Cdd:cd06640   6 FTKLERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKY----YGSYLKGTKLWIIM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-RVADPDHDHTGF 183
Cdd:cd06640  82 EYLGGGSALDLLRAGPFDEFQIATMLKEILKGLDYLHSEKKIHRDIKAANVLLSEQGDVKLADFGVAgQLTDTQIKRNTF 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 184 lteyVATRWYRAPEIMLNSkGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI 240
Cdd:cd06640 162 ----VGTPFWMAPEVIQQS-AYDSKADIWSLGITAIELAKGEPPNSDMHPMRVLFLI 213
PHA03210 PHA03210
serine/threonine kinase US3; Provisional
24-311 1.29e-17

serine/threonine kinase US3; Provisional


Pssm-ID: 165476 [Multi-domain]  Cd Length: 501  Bit Score: 83.97  E-value: 1.29e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   24 RYTNLSYIGEGAYG--MVCSAYDNVNKVRVAIKKISPFEHQTYCQRTL---------------REIKILLRFRHENIIGI 86
Cdd:PHA03210 149 HFRVIDDLPAGAFGkiFICALRASTEEAEARRGVNSTNQGKPKCERLIakrvkagsraaiqleNEILALGRLNHENILKI 228
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   87 NDIIRAPTieqmkDVYIVQDLMETDLYKLLKTQHLS-ND-----HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNtt 160
Cdd:PHA03210 229 EEILRSEA-----NTYMITQKYDFDLYSFMYDEAFDwKDrpllkQTRAIMKQLLCAVEYIHDKKLIHRDIKLENIFLN-- 301
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  161 CDLKIC--DFGLARVAdpDHDHTGFLTEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNR--PI-----FPGK 231
Cdd:PHA03210 302 CDGKIVlgDFGTAMPF--EKEREAFDYGWVGTVATNSPE-ILAGDGYCEITDIWSCGLILLDMLSHDfcPIgdgggKPGK 378
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  232 hyldQLNHILGILGSPSQE--DLNCiinlKARNYLLS-----LPHKNKVPWNRLFPNADSKAldLLDKMLTFNPHKRIEV 304
Cdd:PHA03210 379 ----QLLKIIDSLSVCDEEfpDPPC----KLFDYIDSaeidhAGHSVPPLIRNLGLPADFEY--PLVKMLTFDWHLRPGA 448

                 ....*..
gi 66932916  305 EQALAHP 311
Cdd:PHA03210 449 AELLALP 455
PKc_MKK4 cd06616
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
26-237 1.42e-17

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 4; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK4 is a dual-specificity PK that phosphorylates and activates the downstream targets, c-Jun N-terminal kinase (JNK) and p38 MAPK, on specific threonine and tyrosine residues. JNK and p38 are collectively known as stress-activated MAPKs, as they are activated in response to a variety of environmental stresses and pro-inflammatory cytokines. Their activation is associated with the induction of cell death. Mice deficient in MKK4 die during embryogenesis and display anemia, severe liver hemorrhage, and abnormal hepatogenesis. MKK4 may also play roles in the immune system and in cardiac hypertrophy. It plays a major role in cancer as a tumor and metastasis suppressor. Under certain conditions, MKK4 is pro-oncogenic. The MKK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270790 [Multi-domain]  Cd Length: 291  Bit Score: 82.03  E-value: 1.42e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  26 TNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRH-ENII---GIndiiraptIEQMKDV 101
Cdd:cd06616   9 KDLGEIGRGAFGTVNKMLHKPSGTIMAVKRIRSTVDEKEQKRLLMDLDVVMRSSDcPYIVkfyGA--------LFREGDC 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMETDLYKLLKT------QHLSNDHICYFLYQILRGLKYIHSA-NVLHRDLKPSNLLLNTTCDLKICDFGLArva 174
Cdd:cd06616  81 WICMELMDISLDKFYKYvyevldSVIPEEILGKIAVATVKALNYLKEElKIIHRDVKPSNILLDRNGNIKLCDFGIS--- 157
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 175 dpdhdhtGFLTEYVAT------RWYRAPEIMLNS---KGYTKSIDIWSVGCILAEMLSNRPIFPG-KHYLDQL 237
Cdd:cd06616 158 -------GQLVDSIAKtrdagcRPYMAPERIDPSasrDGYDVRSDVWSLGITLYEVATGKFPYPKwNSVFDQL 223
STKc_ACVR2 cd14053
Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the ...
51-261 1.76e-17

Catalytic domain of the Serine/Threonine Kinase, Activin Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as ACVR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. Vertebrates contain two ACVR2 proteins, ACVR2a (or ActRIIA) and ACVR2b (or ActRIIB). The ACVR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270955 [Multi-domain]  Cd Length: 290  Bit Score: 81.61  E-value: 1.76e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  51 VAIKKISPFEHQTYcqRTLREIKILLRFRHENI---IGINDIIRAPTIEqmkdVYIVQDLMET-DLYKLLKTQHLSNDHI 126
Cdd:cd14053  21 VAVKIFPLQEKQSW--LTEREIYSLPGMKHENIlqfIGAEKHGESLEAE----YWLITEFHERgSLCDYLKGNVISWNEL 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 127 CYFLYQILRGLKYIHS----------ANVLHRDLKPSNLLLN---TTCdlkICDFGLARVADPDHDhTGFLTEYVATRWY 193
Cdd:cd14053  95 CKIAESMARGLAYLHEdipatngghkPSIAHRDFKSKNVLLKsdlTAC---IADFGLALKFEPGKS-CGDTHGQVGTRRY 170
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 194 RAPEIMLNSKGYTKS----IDIWSVGCILAEMLSnRPIFPGKH---YLDQLNHILGIlgSPSQEDL-NCIINLKAR 261
Cdd:cd14053 171 MAPEVLEGAINFTRDaflrIDMYAMGLVLWELLS-RCSVHDGPvdeYQLPFEEEVGQ--HPTLEDMqECVVHKKLR 243
STKc_NDR_like cd05599
Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases; STKs ...
28-228 1.83e-17

Catalytic domain of Nuclear Dbf2-Related kinase-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR kinases regulate mitosis, cell growth, embryonic development, and neurological processes. They are also required for proper centrosome duplication. Higher eukaryotes contain two NDR isoforms, NDR1 and NDR2. This subfamily also contains fungal NDR-like kinases. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270750 [Multi-domain]  Cd Length: 324  Bit Score: 81.89  E-value: 1.83e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGmvcsaydnvnKVRVAIKKISpfeHQTYCQRTLREIKILLRFRHENIIGINDIIRA---PTIEQMKdvYIV 104
Cdd:cd05599   6 LKVIGRGAFG----------EVRLVRKKDT---GHVYAMKKLRKSEMLEKEQVAHVRAERDILAEadnPWVVKLY--YSF 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QD------LME----TDLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV 173
Cdd:cd05599  71 QDeenlylIMEflpgGDMMTLLmKKDTLTEEETRFYIAETVLAIESIHKLGYIHRDIKPDNLLLDARGHIKLSDFGLCTG 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 174 ADPdhDHTGFLTeyVATRWYRAPEIMLNsKGYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd05599 151 LKK--SHLAYST--VGTPDYIAPEVFLQ-KGYGKECDWWSLGVIMYEMLIGYPPF 200
STKc_Aurora-B_like cd14117
Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs ...
31-314 2.59e-17

Catalytic domain of the Serine/Threonine kinase, Aurora-B kinase and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Aurora kinases are key regulators of mitosis and are essential for the accurate and equal division of genomic material from parent to daughter cells. Vertebrates contain at least 2 Aurora kinases (A and B); mammals contains a third Aurora kinase gene (C). This subfamily includes Aurora-B and Aurora-C. Aurora-B is most active at the transition during metaphase to the end of mitosis. It associates with centromeres, relocates to the midzone of the central spindle, and concentrates at the midbody during cell division. It is critical for accurate chromosomal segregation, cytokinesis, protein localization to the centrosome and kinetochore, correct microtubule-kinetochore attachments, and regulation of the mitotic checkpoint. Aurora-C is mainly expressed in meiotically dividing cells; it was originally discovered in mice as a testis-specific STK called Aie1. Both Aurora-B and -C are chromosomal passenger proteins that can form complexes with INCENP and survivin, and they may have redundant cellular functions. INCENP participates in the activation of Aurora-B in a two-step process: first by binding to form an intermediate state of activation and the phosphorylation of its C-terminal TSS motif to generate the fully active kinase. The Aurora-B subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271019 [Multi-domain]  Cd Length: 270  Bit Score: 80.68  E-value: 2.59e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKI--SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLM 108
Cdd:cd14117  14 LGKGKFGNVYLAREKQSKFIVALKVLfkSQIEKEGVEHQLRREIEIQSHLRHPNILRLYNYF-----HDRKRIYLILEYA 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 -ETDLYK-LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgflte 186
Cdd:cd14117  89 pRGELYKeLQKHGRFDEQRTATFMEELADALHYCHEKKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRT----- 163
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 187 YVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGIlgspsqeDLnciinlkarnylls 266
Cdd:cd14117 164 MCGTLDYLPPE-MIEGRTHDEKVDLWCIGVLCYELLVGMPPFESASHTETYRRIVKV-------DL-------------- 221
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 66932916 267 lphknKVPwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd14117 222 -----KFP-----PFLSDGSRDLISKLLRYHPSERLPLKGVMEHPWVK 259
STKc_Nek11 cd08222
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
132-313 3.51e-17

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 11; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek11 is involved, through direct phosphorylation, in regulating the degradation of Cdc25A (Cell Division Cycle 25 homolog A), which plays a role in cell cycle progression and in activating cyclin dependent kinases. Nek11 is activated by CHK1 (CHeckpoint Kinase 1) and may be involved in the G2/M checkpoint. Nek11 may also play a role in the S-phase checkpoint as well as in DNA replication and genotoxic stress responses. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270861 [Multi-domain]  Cd Length: 260  Bit Score: 80.16  E-value: 3.51e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCdLKICDFGLARVADPDHDhtgFLTEYVATRWYRAPEImLNSKGYTKSIDI 211
Cdd:cd08222 114 QLLLAVQYMHERRILHRDLKAKNIFLKNNV-IKVGDFGISRILMGTSD---LATTFTGTPYYMSPEV-LKHEGYNSKSDI 188
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 212 WSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsqedlnciinlkarnyllslphKNKVPwnrLFPNADSKAL-DLL 290
Cdd:cd08222 189 WSLGCILYEMCCLKHAFDGQNLLSVMYKIV----------------------------EGETP---SLPDKYSKELnAIY 237
                       170       180
                ....*....|....*....|...
gi 66932916 291 DKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd08222 238 SRMLNKDPALRPSAAEILKIPFI 260
PTKc_Fes_like cd05041
Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; ...
31-223 3.66e-17

Catalytic domain of Fes-like Protein Tyrosine Kinases; Protein Tyrosine Kinase (PTK) family; Fes subfamily; catalytic (c) domain. Fes subfamily members include Fes (or Fps), Fer, and similar proteins. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes subfamily proteins are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated tyr kinase activity. Fes and Fer kinases play roles in haematopoiesis, inflammation and immunity, growth factor signaling, cytoskeletal regulation, cell migration and adhesion, and the regulation of cell-cell interactions. Fes and Fer show redundancy in their biological functions.


Pssm-ID: 270637 [Multi-domain]  Cd Length: 251  Bit Score: 80.18  E-value: 3.66e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENI---IGIndiiraptIEQMKDVYIVQDL 107
Cdd:cd05041   3 IGRGNFGDVYRGVLKPDNTEVAVKTCRETLPPDLKRKFLQEARILKQYDHPNIvklIGV--------CVQKQPIMIVMEL 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 MET-DLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFL 184
Cdd:cd05041  75 VPGgSLLTFLRKKgaRLTVKQLLQMCLDAAAGMEYLESKNCIHRDLAARNCLVGENNVLKISDFGMSREEEDGEYTVSDG 154
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 66932916 185 TEYVATRWyRAPEiMLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05041 155 LKQIPIKW-TAPE-ALNYGRYTSESDVWSFGILLWEIFS 191
PTKc_EphR_A cd05066
Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze ...
31-226 3.69e-17

Catalytic domain of the Protein Tyrosine Kinases, Class EphA Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily is composed of most class EphA receptors including EphA3, EphA4, EphA5, and EphA7, but excluding EphA1, EphA2 and EphA10. Class EphA receptors bind GPI-anchored ephrin-A ligands. There are ten vertebrate EphA receptors (EphA1-10), which display promiscuous interactions with six ephrin-A ligands. One exception is EphA4, which also binds ephrins-B2/B3. EphA receptors and ephrin-A ligands are expressed in multiple areas of the developing brain, especially in the retina and tectum. They are part of a system controlling retinotectal mapping. EphRs comprise the largest subfamily of receptor PTKs (RTKs). EphRs contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion, making it important in neural development and plasticity, cell morphogenesis, cell-fate determination, embryonic development, tissue patterning, and angiogenesis. The EphA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270651 [Multi-domain]  Cd Length: 267  Bit Score: 80.30  E-value: 3.69e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNV---NKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDL 107
Cdd:cd05066  12 IGAGEFGEVCSGRLKLpgkREIPVAIKTLKAGYTEKQRRDFLSEASIMGQFDHPNIIHLEGVV-----TRSKPVMIVTEY 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 MET-DLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVA--DPDHDHTG 182
Cdd:cd05066  87 MENgSLDAFLRKHdgQFTVIQLVGMLRGIASGMKYLSDMGYVHRDLAARNILVNSNLVCKVSDFGLSRVLedDPEAAYTT 166
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 66932916 183 FLTEyVATRWyRAPEIMLNSKgYTKSIDIWSVGCILAEMLS--NRP 226
Cdd:cd05066 167 RGGK-IPIRW-TAPEAIAYRK-FTSASDVWSYGIVMWEVMSygERP 209
STKc_STK10 cd06644
Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase ...
31-327 3.72e-17

Catalytic domain of the Serine/Threonine Kinase, STK10 (also called Lymphocyte-Oriented Kinase or LOK); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. STK10/LOK is also called polo-like kinase kinase 1 in Xenopus (xPlkk1). It is highly expressed in lymphocytes and is responsible in regulating leukocyte function associated antigen (LFA-1)-mediated lymphocyte adhesion. It plays a role in regulating the CD28 responsive element in T cells, and may also function as a regulator of polo-like kinase 1 (Plk1), a protein which is overexpressed in multiple tumor types. The STK10 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132975 [Multi-domain]  Cd Length: 292  Bit Score: 80.85  E-value: 3.72e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPfEHQTYCQRTLREIKILLRFRHENIIGINDIIRAP-----TIEQMKDVYIVQ 105
Cdd:cd06644  20 LGDGAFGKVYKAKNKETGALAAAKVIET-KSEEELEDYMVEIEILATCNHPYIVKLLGAFYWDgklwiMIEFCPGGAVDA 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETDlykllktQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGlarVADPDHDHTGFLT 185
Cdd:cd06644  99 IMLELD-------RGLTEPQIQVICRQMLEALQYLHSMKIIHRDLKAGNVLLTLDGDIKLADFG---VSAKNVKTLQRRD 168
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 EYVATRWYRAPEIM----LNSKGYTKSIDIWSVGCILAEMLSnrpIFPGKHYLDQLNHILGIlgspsqedlnciinLKAR 261
Cdd:cd06644 169 SFIGTPYWMAPEVVmcetMKDTPYDYKADIWSLGITLIEMAQ---IEPPHHELNPMRVLLKI--------------AKSE 231
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 262 NYLLSLPHKnkvpWNRLFPnadskalDLLDKMLTFNPHKRIEVEQALAHPYLEQYYD--PSDEPIAEA 327
Cdd:cd06644 232 PPTLSQPSK----WSMEFR-------DFLKTALDKHPETRPSAAQLLEHPFVSSVTSnrPLRELVAEA 288
PTKc_EphR cd05033
Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of ...
31-226 4.10e-17

Catalytic domain of Ephrin Receptor Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They can be classified into two classes (EphA and EphB), according to their extracellular sequences, which largely correspond to binding preferences for either GPI-anchored ephrin-A ligands or transmembrane ephrin-B ligands. Vertebrates have ten EphA and six EphB receptors, which display promiscuous ligand interactions within each class. EphRs contain an ephrin binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. This allows ephrin/EphR dimers to form, leading to the activation of the intracellular tyr kinase domain. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). The main effect of ephrin/EphR interaction is cell-cell repulsion or adhesion. Ephrin/EphR signaling is important in neural development and plasticity, cell morphogenesis and proliferation, cell-fate determination, embryonic development, tissue patterning, and angiogenesis.The EphR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270629 [Multi-domain]  Cd Length: 266  Bit Score: 80.11  E-value: 4.10e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVR---VAIKKISPfeHQTYCQRT--LREIKILLRFRHENIIGINDIIRAptieqMKDVYIVQ 105
Cdd:cd05033  12 IGGGEFGEVCSGSLKLPGKKeidVAIKTLKS--GYSDKQRLdfLTEASIMGQFDHPNVIRLEGVVTK-----SRPVMIVT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMET-DLYKLLKT--QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV---ADPDHD 179
Cdd:cd05033  85 EYMENgSLDKFLREndGKFTVTQLVGMLRGIASGMKYLSEMNYVHRDLAARNILVNSDLVCKVSDFGLSRRledSEATYT 164
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 180 HTGfltEYVATRWyRAPEiMLNSKGYTKSIDIWSVGCILAEMLS--NRP 226
Cdd:cd05033 165 TKG---GKIPIRW-TAPE-AIAYRKFTSASDVWSFGIVMWEVMSygERP 208
PTKc_Yes cd05069
Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the ...
31-230 4.27e-17

Catalytic domain of the Protein Tyrosine Kinase, Yes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Yes (or c-Yes) is a member of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. c-Yes kinase is the cellular homolog of the oncogenic protein (v-Yes) encoded by the Yamaguchi 73 and Esh sarcoma viruses. It displays functional overlap with other Src subfamily members, particularly Src. It also shows some unique functions such as binding to occludins, transmembrane proteins that regulate extracellular interactions in tight junctions. Yes also associates with a number of proteins in different cell types that Src does not interact with, like JAK2 and gp130 in pre-adipocytes, and Pyk2 in treated pulmonary vein endothelial cells. Although the biological function of Yes remains unclear, it appears to have a role in regulating cell-cell interactions and vesicle trafficking in polarized cells. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Yes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270654 [Multi-domain]  Cd Length: 279  Bit Score: 80.50  E-value: 4.27e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNvNKVRVAIKKISPFEHQTycQRTLREIKILLRFRHENIIGINDIIRAPTIeqmkdvYIVQDLMET 110
Cdd:cd05069  20 LGQGCFGEVWMGTWN-GTTKVAIKTLKPGTMMP--EAFLQEAQIMKKLRHDKLVPLYAVVSEEPI------YIVTEFMGK 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 ----DLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpDHDHTGFLTE 186
Cdd:cd05069  91 gsllDFLKEGDGKYLKLPQLVDMAAQIADGMAYIERMNYIHRDLRAANILVGDNLVCKIADFGLARLIE-DNEYTARQGA 169
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 66932916 187 YVATRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLSN-RPIFPG 230
Cdd:cd05069 170 KFPIKW-TAPEAALYGRFTIKS-DVWSFGILLTELVTKgRVPYPG 212
PTKc_Tec_like cd05059
Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
26-223 4.35e-17

Catalytic domain of Tec-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Tec-like subfamily is composed of Tec, Btk, Bmx (Etk), Itk (Tsk, Emt), Rlk (Txk), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, some members contain the Tec homology (TH) domain, which contains proline-rich and zinc-binding regions. Tec kinases form the second largest subfamily of nonreceptor PTKs and are expressed mainly by haematopoietic cells, although Tec and Bmx are also found in endothelial cells. B-cells express Btk and Tec, while T-cells express Itk, Txk, and Tec. Collectively, Tec kinases are expressed in a variety of myeloid cells such as mast cells, platelets, macrophages, and dendritic cells. Each Tec kinase shows a distinct cell-type pattern of expression. Tec kinases play important roles in the development, differentiation, maturation, regulation, survival, and function of B-cells and T-cells. Mutations in Btk cause the severe B-cell immunodeficiency, X-linked agammaglobulinaemia (XLA). The Tec-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173637 [Multi-domain]  Cd Length: 256  Bit Score: 79.80  E-value: 4.35e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  26 TNLSYIGEGAYGMVCSAYDNvNKVRVAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVQ 105
Cdd:cd05059   7 TFLKELGSGQFGVVHLGKWR-GKIDVAIKMIK--EGSMSEDDFIEEAKVMMKLSHPKLVQLYGVC-----TKQRPIFIVT 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETD-LYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDhdhtg 182
Cdd:cd05059  79 EYMANGcLLNYLRERRgkFQTEQLLEMCKDVCEAMEYLESNGFIHRDLAARNCLVGEQNVVKVSDFGLARYVLDD----- 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 66932916 183 fltEYVAT-------RWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05059 154 ---EYTSSvgtkfpvKW-SPPEVFMYSKFSSKS-DVWSFGVLMWEVFS 196
PTKc_EphR_B cd05065
Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; PTKs catalyze ...
31-226 4.79e-17

Catalytic domain of the Protein Tyrosine Kinases, Class EphB Ephrin Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Class EphB receptors bind to transmembrane ephrin-B ligands. There are six vertebrate EphB receptors (EphB1-6), which display promiscuous interactions with three ephrin-B ligands. One exception is EphB2, which also interacts with ephrin A5. EphB receptors play important roles in synapse formation and plasticity, spine morphogenesis, axon guidance, and angiogenesis. In the intestinal epithelium, EphBs are Wnt signaling target genes that control cell compartmentalization. They function as suppressors of colon cancer progression. EphRs comprise the largest subfamily of receptor PTKs (RTKs). They contain an ephrin-binding domain and two fibronectin repeats extracellularly, a transmembrane segment, and a cytoplasmic tyr kinase domain. Binding of the ephrin ligand to EphR requires cell-cell contact since both are anchored to the plasma membrane. The resulting downstream signals occur bidirectionally in both EphR-expressing cells (forward signaling) and ephrin-expressing cells (reverse signaling). Ephrin/EphR interaction mainly results in cell-cell repulsion or adhesion. The EphB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173638 [Multi-domain]  Cd Length: 269  Bit Score: 79.91  E-value: 4.79e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNV---NKVRVAIK--KISPFEHQTycQRTLREIKILLRFRHENIIGINDIIRAPTieqmkDVYIVQ 105
Cdd:cd05065  12 IGAGEFGEVCRGRLKLpgkREIFVAIKtlKSGYTEKQR--RDFLSEASIMGQFDHPNIIHLEGVVTKSR-----PVMIIT 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMET---DLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD---PDHD 179
Cdd:cd05065  85 EFMENgalDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLSEMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEddtSDPT 164
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 180 HTGFLTEYVATRWyRAPEIMLNSKgYTKSIDIWSVGCILAEMLS--NRP 226
Cdd:cd05065 165 YTSSLGGKIPIRW-TAPEAIAYRK-FTSASDVWSYGIVMWEVMSygERP 211
PTKc_Jak2_rpt2 cd14205
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the ...
28-268 4.98e-17

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak2 is widely expressed in many tissues and is essential for the signaling of hormone-like cytokines such as growth hormone, erythropoietin, thrombopoietin, and prolactin, as well as some IFNs and cytokines that signal through the IL-3 and gp130 receptors. Disruption of Jak2 in mice results in an embryonic lethal phenotype with multiple defects including erythropoietic and cardiac abnormalities. It is the only Jak gene that results in a lethal phenotype when disrupted in mice. A mutation in the pseudokinase domain of Jak2, V617F, is present in many myeloproliferative diseases, including almost all patients with polycythemia vera, and 50% of patients with essential thrombocytosis and myelofibrosis. Jak2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271107 [Multi-domain]  Cd Length: 284  Bit Score: 80.06  E-value: 4.98e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGMV--CS---AYDNVNKVrVAIKKIspfEHQT--YCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKd 100
Cdd:cd14205   9 LQQLGKGNFGSVemCRydpLQDNTGEV-VAVKKL---QHSTeeHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLR- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 vYIVQDLMETDLYKLLKTQHLSNDHICYFLY--QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDh 178
Cdd:cd14205  84 -LIMEYLPYGSLRDYLQKHKERIDHIKLLQYtsQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQD- 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 dhtgflTEYVATR--------WYrAPEIMLNSKgYTKSIDIWSVGCILAEML--SNRPIFPGKHYLDQlnhilgiLGSPS 248
Cdd:cd14205 162 ------KEYYKVKepgespifWY-APESLTESK-FSVASDVWSFGVVLYELFtyIEKSKSPPAEFMRM-------IGNDK 226
                       250       260
                ....*....|....*....|..
gi 66932916 249 QEDLNC--IINLKARNYLLSLP 268
Cdd:cd14205 227 QGQMIVfhLIELLKNNGRLPRP 248
STKc_CK1 cd14016
Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the ...
24-172 5.30e-17

Catalytic domain of the Serine/Threonine protein kinase, Casein Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CK1 phosphorylates a variety of substrates including enzymes, transcription and splice factors, cytoskeletal proteins, viral oncogenes, receptors, and membrane-associated proteins. There are mutliple isoforms of CK1 and in mammals, seven isoforms (alpha, beta, gamma1-3, delta, and epsilon) have been characterized. These isoforms differ mainly in the length and structure of their C-terminal non-catalytic region. Some isoforms have several splice variants such as the long (L) and short (S) variants of CK1alpha. CK1 proteins are involved in the regulation of many cellular processes including membrane transport processes, circadian rhythm, cell division, apoptosis, and the development of cancer and neurodegenerative diseases. The CK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270918 [Multi-domain]  Cd Length: 266  Bit Score: 79.81  E-value: 5.30e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKkispFEHQTYCQRTL-REIKILLRFRheNIIGIndiiraPTI----EQM 98
Cdd:cd14016   1 RYKLVKKIGSGSFGEVYLGIDLKTGEEVAIK----IEKKDSKHPQLeYEAKVYKLLQ--GGPGI------PRLywfgQEG 68
                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916  99 KDVYIVQDLMETDLYKLLKT--QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLK---ICDFGLAR 172
Cdd:cd14016  69 DYNVMVMDLLGPSLEDLFNKcgRKFSLKTVLMLADQMISRLEYLHSKGYIHRDIKPENFLMGLGKNSNkvyLIDFGLAK 147
PknB_PASTA_kin NF033483
Stk1 family PASTA domain-containing Ser/Thr kinase;
24-230 5.59e-17

Stk1 family PASTA domain-containing Ser/Thr kinase;


Pssm-ID: 468045 [Multi-domain]  Cd Length: 563  Bit Score: 82.15  E-value: 5.59e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   24 RYTNLSYIGEGayGM--VCSAYDNVNKVRVAIKKIspfeHQTYCqrtlREIKILLRFRHE--NIIGINDiiraPTIEQMK 99
Cdd:NF033483   8 RYEIGERIGRG--GMaeVYLAKDTRLDRDVAVKVL----RPDLA----RDPEFVARFRREaqSAASLSH----PNIVSVY 73
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  100 DV-------YIVqdlME----TDLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICD 167
Cdd:NF033483  74 DVgedggipYIV---MEyvdgRTLKDYIREHGpLSPEEAVEIMIQILSALEHAHRNGIVHRDIKPQNILITKDGRVKVTD 150
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916  168 FGLAR-VADPDHDHTGFLteyVATRWYRAPEIMLNSKGYTKSiDIWSVGCILAEMLSNRPIFPG 230
Cdd:NF033483 151 FGIARaLSSTTMTQTNSV---LGTVHYLSPEQARGGTVDARS-DIYSLGIVLYEMLTGRPPFDG 210
PTKc_Frk_like cd05068
Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the ...
28-239 5.88e-17

Catalytic domain of Fyn-related kinase-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Frk and Srk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Frk, also known as Rak, is specifically expressed in liver, lung, kidney, intestine, mammary glands, and the islets of Langerhans. Rodent homologs were previously referred to as GTK (gastrointestinal tyr kinase), BSK (beta-cell Src-like kinase), or IYK (intestinal tyr kinase). Studies in mice reveal that Frk is not essential for viability. It plays a role in the signaling that leads to cytokine-induced beta-cell death in Type I diabetes. It also regulates beta-cell number during embryogenesis and early in life. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Frk-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270653 [Multi-domain]  Cd Length: 267  Bit Score: 79.76  E-value: 5.88e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGMVCSAYDNvNKVRVAIKKISPFEHQTycQRTLREIKILLRFRHENIIGINDIIrapTIEQmkDVYIVQDL 107
Cdd:cd05068  13 LRKLGSGQFGEVWEGLWN-NTTPVAVKTLKPGTMDP--EDFLREAQIMKKLRHPKLIQLYAVC---TLEE--PIYIITEL 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 MET-DLYKLL--KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFL 184
Cdd:cd05068  85 MKHgSLLEYLqgKGRSLQLPQLIDMAAQVASGMAYLESQNYIHRDLAARNVLVGENNICKVADFGLARVIKVEDEYEARE 164
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 185 TEYVATRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLS-NRPIFPG---KHYLDQLNH 239
Cdd:cd05068 165 GAKFPIKW-TAPEAANYNRFSIKS-DVWSFGILLTEIVTyGRIPYPGmtnAEVLQQVER 221
PKc_MEK cd06615
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
131-229 6.42e-17

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 and MEK2 are MAPK kinases (MAPKKs or MKKs), and are dual-specificity PKs that phosphorylate and activate the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1/2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. This cascade has also been implicated in synaptic plasticity, migration, morphological determination, and stress response immunological reactions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1/2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132946 [Multi-domain]  Cd Length: 308  Bit Score: 80.17  E-value: 6.42e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 131 YQILRGLKYI---HSanVLHRDLKPSNLLLNTTCDLKICDFGlarVADPDHDHTGflTEYVATRWYRAPEIMLNSKgYTK 207
Cdd:cd06615 106 IAVLRGLTYLrekHK--IMHRDVKPSNILVNSRGEIKLCDFG---VSGQLIDSMA--NSFVGTRSYMSPERLQGTH-YTV 177
                        90       100
                ....*....|....*....|...
gi 66932916 208 SIDIWSVGCILAEMLSNR-PIFP 229
Cdd:cd06615 178 QSDIWSLGLSLVEMAIGRyPIPP 200
PHA03209 PHA03209
serine/threonine kinase US3; Provisional
68-311 6.50e-17

serine/threonine kinase US3; Provisional


Pssm-ID: 177557 [Multi-domain]  Cd Length: 357  Bit Score: 80.69  E-value: 6.50e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   68 TLREIKILLRFRHENIIGINDIIRAPTIEQMkdvyiVQDLMETDLYKLL--KTQHLSNDHICYFLYQILRGLKYIHSANV 145
Cdd:PHA03209 104 TLIEAMLLQNVNHPSVIRMKDTLVSGAITCM-----VLPHYSSDLYTYLtkRSRPLPIDQALIIEKQILEGLRYLHAQRI 178
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  146 LHRDLKPSNLLLNTTCDLKICDFGLAR--VADPDhdhtgFLTeYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLS 223
Cdd:PHA03209 179 IHRDVKTENIFINDVDQVCIGDLGAAQfpVVAPA-----FLG-LAGTVETNAPEVLARDK-YNSKADIWSAGIVLFEMLA 251
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  224 -------NRPIFPGKHYLDQLNHILGILGS--------PSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKAld 288
Cdd:PHA03209 252 ypstifeDPPSTPEEYVKSCHSHLLKIISTlkvhpeefPRDPGSRLVRGFIEYASLERQPYTRYPCFQRVNLPIDGEF-- 329
                        250       260
                 ....*....|....*....|...
gi 66932916  289 LLDKMLTFNPHKRIEVEQALAHP 311
Cdd:PHA03209 330 LVHKMLTFDAAMRPSAEEILNYP 352
PTZ00263 PTZ00263
protein kinase A catalytic subunit; Provisional
31-312 6.55e-17

protein kinase A catalytic subunit; Provisional


Pssm-ID: 140289 [Multi-domain]  Cd Length: 329  Bit Score: 80.63  E-value: 6.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   31 IGEGAYGmvcsaydnvnKVRVAIKKISpfeHQTYCQRTLREIKILLRFRHENIIGINDIIRA---PTIEQM-------KD 100
Cdd:PTZ00263  26 LGTGSFG----------RVRIAKHKGT---GEYYAIKCLKKREILKMKQVQHVAQEKSILMElshPFIVNMmcsfqdeNR 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  101 VYIVQD-LMETDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-RVADPD 177
Cdd:PTZ00263  93 VYFLLEfVVGGELFTHLRKAgRFPNDVAKFYHAELVLAFEYLHSKDIIYRDLKPENLLLDNKGHVKVTDFGFAkKVPDRT 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  178 HDHTGflteyvaTRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhyLDQlnhilgilgSPsqedlnciin 257
Cdd:PTZ00263 173 FTLCG-------TPEYLAPEV-IQSKGHGKAVDWWTMGVLLYEFIAGYPPF-----FDD---------TP---------- 220
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916  258 lkARNYllslphkNKVPWNRL-FPN-ADSKALDLLDKMLTFNPHKRI-----EVEQALAHPY 312
Cdd:PTZ00263 221 --FRIY-------EKILAGRLkFPNwFDGRARDLVKGLLQTDHTKRLgtlkgGVADVKNHPY 273
STKc_RSK_N cd05582
N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; ...
31-278 7.21e-17

N-terminal catalytic domain of the Serine/Threonine Kinase, 90 kDa ribosomal protein S6 kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. They are activated by signaling inputs from extracellular regulated kinase (ERK) and phosphoinositide dependent kinase 1 (PDK1). ERK phosphorylates and activates the CTD of RSK, serving as a docking site for PDK1, which phosphorylates and activates the NTD, which in turn phosphorylates all known RSK substrates. RSKs act as downstream effectors of mitogen-activated protein kinase (MAPK) and play key roles in mitogen-activated cell growth, differentiation, and survival. Mammals possess four RSK isoforms (RSK1-4) from distinct genes. RSK proteins are also referred to as MAP kinase-activated protein kinases (MAPKAPKs), p90-RSKs, or p90S6Ks. The RSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270734 [Multi-domain]  Cd Length: 317  Bit Score: 80.14  E-value: 7.21e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGmvcsaydnvnKVRVAIKKISPFEHQTYCQRTLRE--IKILLRFRHENIIGINDIIRAPTIEQMK-------DV 101
Cdd:cd05582   3 LGQGSFG----------KVFLVRKITGPDAGTLYAMKVLKKatLKVRDRVRTKMERDILADVNHPFIVKLHyafqtegKL 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMET-DLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHD 179
Cdd:cd05582  73 YLILDFLRGgDLFtRLSKEVMFTEEDVKFYLAELALALDHLHSLGIIYRDLKPENILLDEDGHIKLTDFGLSKESIDHEK 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 HTgflTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL-GILGSP---SQEdlnci 255
Cdd:cd05582 153 KA---YSFCGTVEYMAPEV-VNRRGHTQSADWWSFGVLMFEMLTGSLPFQGKDRKETMTMILkAKLGMPqflSPE----- 223
                       250       260
                ....*....|....*....|...
gi 66932916 256 inlkARNYLLSLPHKNkvPWNRL 278
Cdd:cd05582 224 ----AQSLLRALFKRN--PANRL 240
STKc_PKC cd05570
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer ...
106-312 7.38e-17

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, classical PKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. Novel PKCs are calcium-independent, but require DAG and PS for activity, while atypical PKCs only require PS. PKCs phosphorylate and modify the activities of a wide variety of cellular proteins including receptors, enzymes, cytoskeletal proteins, transcription factors, and other kinases. They play a central role in signal transduction pathways that regulate cell migration and polarity, proliferation, differentiation, and apoptosis. Also included in this subfamily are the PKC-like proteins, called PKNs. The PKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270722 [Multi-domain]  Cd Length: 318  Bit Score: 80.34  E-value: 7.38e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMetdlYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgflT 185
Cdd:cd05570  82 DLM----FHIQRARRFTEERARFYAAEICLALQFLHERGIIYRDLKLDNVLLDAEGHIKIADFGMCKEGIWGGNTT---S 154
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 EYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhyldqlnhilgilgspSQEDL-NCIINlkarnyl 264
Cdd:cd05570 155 TFCGTPDYIAPEI-LREQDYGFSVDWWALGVLLYEMLAGQSPFEGD----------------DEDELfEAILN------- 210
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 265 lslphkNKVpwnrLFPNADSK-ALDLLDKMLTFNPHKRIEV-----EQALAHPY 312
Cdd:cd05570 211 ------DEV----LYPRWLSReAVSILKGLLTKDPARRLGCgpkgeADIKAHPF 254
pknD PRK13184
serine/threonine-protein kinase PknD;
24-229 7.66e-17

serine/threonine-protein kinase PknD;


Pssm-ID: 183880 [Multi-domain]  Cd Length: 932  Bit Score: 82.13  E-value: 7.66e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISP--FEHQTYCQRTLREIKILLRFRHENIIGINdiirapTIEQMKD- 100
Cdd:PRK13184   3 RYDIIRLIGKGGMGEVYLAYDPVCSRRVALKKIREdlSENPLLKKRFLREAKIAADLIHPGIVPVY------SICSDGDp 76
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  101 VYIVQDLME-TDLYKLLKT----QHLSNDH-----ICYFL---YQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICD 167
Cdd:PRK13184  77 VYYTMPYIEgYTLKSLLKSvwqkESLSKELaektsVGAFLsifHKICATIEYVHSKGVLHRDLKPDNILLGLFGEVVILD 156
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916  168 FGLARVADPDHDHTGFLT---------------EYVATRWYRAPEIMLNSKGyTKSIDIWSVGCILAEMLSNRpiFP 229
Cdd:PRK13184 157 WGAAIFKKLEEEDLLDIDvdernicyssmtipgKIVGTPDYMAPERLLGVPA-SESTDIYALGVILYQMLTLS--FP 230
STKc_GRK cd05577
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs ...
31-237 7.68e-17

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. GRKs play important roles in the cardiovascular, immune, respiratory, skeletal, and nervous systems. They contain a central catalytic domain, flanked by N- and C-terminal extensions. The N-terminus contains an RGS (regulator of G protein signaling) homology (RH) domain and several motifs. The C-terminus diverges among different groups of GRKs. There are seven types of GRKs, named GRK1 to GRK7, which are subdivided into three main groups: visual (GRK1/7); beta-adrenergic receptor kinases (GRK2/3); and GRK4-like (GRK4/5/6). Expression of GRK2/3/5/6 is widespread while GRK1/4/7 show a limited tissue distribution. The substrate spectrum of the widely expressed GRKs partially overlaps. The GRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270729 [Multi-domain]  Cd Length: 278  Bit Score: 79.49  E-value: 7.68e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCS----------AYDNVNKVRVAIKKISpfehqtycQRTLREIKILLRFRHENIIGIndiirAPTIEQMKD 100
Cdd:cd05577   1 LGRGGFGEVCAcqvkatgkmyACKKLDKKRIKKKKGE--------TMALNEKIILEKVSSPFIVSL-----AYAFETKDK 67
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLMETDLYKLLKTQH----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLArVADP 176
Cdd:cd05577  68 LCLVLTLMNGGDLKYHIYNVgtrgFSEARAIFYAAEIICGLEHLHNRFIVYRDLKPENILLDDHGHVRISDLGLA-VEFK 146
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 177 DHDHTgflTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG------KHYLDQL 237
Cdd:cd05577 147 GGKKI---KGRVGTHGYMAPEVLQKEVAYDFSVDWFALGCMLYEMIAGRSPFRQrkekvdKEELKRR 210
STKc_MAP4K4_6_N cd06636
N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase ...
31-313 7.77e-17

N-terminal Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 and 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. MAP4K4 is also called Nck Interacting kinase (NIK). It facilitates the activation of the MAPKs, extracellular signal-regulated kinase (ERK) 1, ERK2, and c-Jun N-terminal kinase (JNK), by phosphorylating and activating MEKK1. MAP4K4 plays a role in tumor necrosis factor (TNF) alpha-induced insulin resistance. MAP4K4 silencing in skeletal muscle cells from type II diabetic patients restores insulin-mediated glucose uptake. MAP4K4, through JNK, also plays a broad role in cell motility, which impacts inflammation, homeostasis, as well as the invasion and spread of cancer. MAP4K4 is found to be highly expressed in most tumor cell lines relative to normal tissue. MAP4K6 (also called MINK for Misshapen/NIKs-related kinase) is activated after Ras induction and mediates activation of p38 MAPK. MAP4K6 plays a role in cell cycle arrest, cytoskeleton organization, cell adhesion, and cell motility. The MAP4K4/6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270806 [Multi-domain]  Cd Length: 282  Bit Score: 79.67  E-value: 7.77e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTycQRTLREIKILLRFRHENIIGI--NDIIRAPTIEQMKDVYIVQDLM 108
Cdd:cd06636  24 VGNGTYGQVYKGRHVKTGQLAAIKVMDVTEDEE--EEIKLEINMLKKYSHHRNIATyyGAFIKKSPPGHDDQLWLVMEFC 101
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 E----TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDhdhTGFL 184
Cdd:cd06636 102 GagsvTDLVKNTKGNALKEDWIAYICREILRGLAHLHAHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT---VGRR 178
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 185 TEYVATRWYRAPEIMLNSKG----YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqedlnciinlkA 260
Cdd:cd06636 179 NTFIGTPYWMAPEVIACDENpdatYDYRSDIWSLGITAIEMAEGAPPLCDMHPMRALFLI-------------------P 239
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 261 RNYLLSLPHKNkvpWNRLFpnadskaLDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06636 240 RNPPPKLKSKK---WSKKF-------IDFIEGCLVKNYLSRPSTEQLLKHPFI 282
STKc_CaMK_like cd14088
Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to ...
65-313 8.17e-17

Catalytic domain of an Uncharacterized group of Serine/Threonine kinases with similarity to Calcium/calmodulin-dependent protein kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of uncharacterized STKs with similarity to CaMKs, which are multifunctional calcium and calmodulin (CaM) stimulated STKs involved in cell cycle regulation. The CaMK family includes CaMKI, CaMKII, CaMKIV, and CaMK kinase (CaMKK). CaMKs contain an N-terminal catalytic domain followed by a regulatory domain that harbors a CaM binding site. This uncharacterized subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270990 [Multi-domain]  Cd Length: 265  Bit Score: 79.30  E-value: 8.17e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  65 CQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQD----LMETDLYK-----LLKTQHLSNDHICYFLYQILR 135
Cdd:cd14088  31 CKKFLKRDGRKVRKAAKNEINILKMVKHPNILQLVDVFETRKeyfiFLELATGRevfdwILDQGYYSERDTSNVIRQVLE 110
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 136 GLKYIHSANVLHRDLKPSNLL-LNTTCDLKIC--DFGLARVadpdhdHTGFLTEYVATRWYRAPEIMLNSKgYTKSIDIW 212
Cdd:cd14088 111 AVAYLHSLKIVHRNLKLENLVyYNRLKNSKIVisDFHLAKL------ENGLIKEPCGTPEYLAPEVVGRQR-YGRPVDCW 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 213 SVGCILAEMLS-NRPIFPGKHYLDQLNHilgilgspsqeDLNCIINLKARNYLLSLPHknkvpWNRLFPNADskalDLLD 291
Cdd:cd14088 184 AIGVIMYILLSgNPPFYDEAEEDDYENH-----------DKNLFRKILAGDYEFDSPY-----WDDISQAAK----DLVT 243
                       250       260
                ....*....|....*....|..
gi 66932916 292 KMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14088 244 RLMEVEQDQRITAEEAISHEWI 265
STKc_NIM1 cd14075
Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the ...
31-223 8.30e-17

Catalytic domain of the Serine/Threonine Kinase, NIM1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NIM1 is a widely-expressed kinase belonging to the AMP-activated protein kinase (AMPK) subfamily. Although present in most tissues, NIM1 kinase activity is only observed in the brain and testis. NIM1 is capable of autophosphorylating and activating itself, but may be present in other tissues in the inactive form. The physiological function of NIM1 has yet to be elucidated. The NIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270977 [Multi-domain]  Cd Length: 255  Bit Score: 78.92  E-value: 8.30e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTL-REIKILLRFRHENIIGINDIIraptiEQMKDVYIVqdlME 109
Cdd:cd14075  10 LGSGNFSQVKLGIHQLTKEKVAIKILDKTKLDQKTQRLLsREISSMEKLHHPNIIRLYEVV-----ETLSKLHLV---ME 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 ----TDLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDhtgfL 184
Cdd:cd14075  82 yasgGELYtKISTEGKLSESEAKPLFAQIVSAVKHMHENNIIHRDLKAENVFYASNNCVKVGDFGFSTHAKRGET----L 157
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 66932916 185 TEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd14075 158 NTFCGSPPYAAPELFKDEHYIGIYVDIWALGVLLYFMVT 196
PTKc_Lck_Blk cd05067
Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs ...
31-230 9.40e-17

Catalytic domain of the Protein Tyrosine Kinases, Lymphocyte-specific kinase and Blk; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Lck and Blk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Lck is expressed in T-cells and natural killer cells. It plays a critical role in T-cell maturation, activation, and T-cell receptor (TCR) signaling. Lck phosphorylates ITAM (immunoreceptor tyr activation motif) sequences on several subunits of TCRs, leading to the activation of different second messenger cascades. Phosphorylated ITAMs serve as binding sites for other signaling factor such as Syk and ZAP-70, leading to their activation and propagation of downstream events. In addition, Lck regulates drug-induced apoptosis by interfering with the mitochondrial death pathway. The apototic role of Lck is independent of its primary function in T-cell signaling. Blk is expressed specifically in B-cells. It is involved in pre-BCR (B-cell receptor) signaling. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Lck/Blk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270652 [Multi-domain]  Cd Length: 264  Bit Score: 79.16  E-value: 9.40e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNvNKVRVAIKKISP--FEHQTYcqrtLREIKILLRFRHENIIGINDIIRAPTIeqmkdvYIVQDLM 108
Cdd:cd05067  15 LGAGQFGEVWMGYYN-GHTKVAIKSLKQgsMSPDAF----LAEANLMKQLQHQRLVRLYAVVTQEPI------YIITEYM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpDHDHTGFL 184
Cdd:cd05067  84 ENgSLVDFLKTPSgikLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADFGLARLIE-DNEYTARE 162
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 185 TEYVATRWyRAPEiMLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPG 230
Cdd:cd05067 163 GAKFPIKW-TAPE-AINYGTFTIKSDVWSFGILLTEIVThGRIPYPG 207
STKc_MLK cd14061
Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the ...
31-230 9.68e-17

Catalytic domain of the Serine/Threonine Kinases, Mixed Lineage Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLKs act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Mammals have four MLKs (MLK1-4), mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270963 [Multi-domain]  Cd Length: 258  Bit Score: 78.97  E-value: 9.68e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFE-HQTYCQRTLREIKILLRFRHENIIGIndiiRAPTIEQMKDVYIVQDLME 109
Cdd:cd14061   2 IGVGGFGKVYRGIWRGEEVAVKAARQDPDEdISVTLENVRQEARLFWMLRHPNIIAL----RGVCLQPPNLCLVMEYARG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHS---ANVLHRDLKPSNLLL----------NTTcdLKICDFGLARvadp 176
Cdd:cd14061  78 GALNRVLAGRKIPPHVLVDWAIQIARGMNYLHNeapVPIIHRDLKSSNILIleaienedleNKT--LKITDFGLAR---- 151
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 177 DHDHTgflTEYVA--TRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPG 230
Cdd:cd14061 152 EWHKT---TRMSAagTYAWMAPEVIKSST-FSKASDVWSYGVLLWELLTGEVPYKG 203
PTKc_Fes cd05084
Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the ...
31-223 1.06e-16

Catalytic domain of the Protein Tyrosine Kinase, Fes; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fes (or Fps) is a cytoplasmic (or nonreceptor) PTK containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. The genes for Fes (feline sarcoma) and Fps (Fujinami poultry sarcoma) were first isolated from tumor-causing retroviruses. The viral oncogenes encode chimeric Fes proteins consisting of Gag sequences at the N-termini, resulting in unregulated PTK activity. Fes kinase is expressed in myeloid, vascular endothelial, epithelial, and neuronal cells. It plays important roles in cell growth and differentiation, angiogenesis, inflammation and immunity, and cytoskeletal regulation. A recent study implicates Fes kinase as a tumor suppressor in colorectal cancer. The Fes subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270667 [Multi-domain]  Cd Length: 252  Bit Score: 78.82  E-value: 1.06e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIS---PFEHQTycqRTLREIKILLRFRHENIIginDIIRAPTieQMKDVYIVQDL 107
Cdd:cd05084   4 IGRGNFGEVFSGRLRADNTPVAVKSCRetlPPDLKA---KFLQEARILKQYSHPNIV---RLIGVCT--QKQPIYIVMEL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 MET-DLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV-ADPDHDHTGF 183
Cdd:cd05084  76 VQGgDFLTFLRTEgpRLKVKELIRMVENAAAGMEYLESKHCIHRDLAARNCLVTEKNVLKISDFGMSREeEDGVYAATGG 155
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 66932916 184 LTEyVATRWyRAPEiMLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05084 156 MKQ-IPVKW-TAPE-ALNYGRYSSESDVWSFGILLWETFS 192
STKc_MAP3K12_13 cd14059
Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase ...
31-223 1.16e-16

Catalytic domain of the Serine/Threonine Kinases, Mitogen-Activated Protein Kinase Kinase Kinases 12 and 13; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP3K12 is also called MAPK upstream kinase (MUK), dual leucine zipper-bearing kinase (DLK) or leucine-zipper protein kinase (ZPK). It is involved in the c-Jun N-terminal kinase (JNK) pathway that directly regulates axonal regulation through the phosphorylation of microtubule-associated protein 1B (MAP1B). It also regulates the differentiation of many cell types including adipocytes and may play a role in adipogenesis. MAP3K13, also called leucine zipper-bearing kinase (LZK), directly phosphorylates and activates MKK7, which in turn activates the JNK pathway. It also activates NF-kB through IKK activation and this activity is enhanced by antioxidant protein-1 (AOP-1). MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAP2Ks (MAPKKs or MKKs), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The MAP3K12/13 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270961 [Multi-domain]  Cd Length: 237  Bit Score: 78.31  E-value: 1.16e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYdnVNKVRVAIKKISPfEHQTycqrtlrEIKILLRFRHENIIGINDI-IRAPtieqmkdVYIVqdLME 109
Cdd:cd14059   1 LGSGAQGAVFLGK--FRGEEVAVKKVRD-EKET-------DIKHLRKLNHPNIIKFKGVcTQAP-------CYCI--LME 61
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 ----TDLYKLLKT-QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFl 184
Cdd:cd14059  62 ycpyGQLYEVLRAgREITPSLLVDWSKQIASGMNYLHLHKIIHRDLKSPNVLVTYNDVLKISDFGTSKELSEKSTKMSF- 140
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 66932916 185 teyVATRWYRAPEIMLNSKGYTKsIDIWSVGCILAEMLS 223
Cdd:cd14059 141 ---AGTVAWMAPEVIRNEPCSEK-VDIWSFGVVLWELLT 175
STKc_MLCK4 cd14193
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze ...
31-313 1.43e-16

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK phosphorylates myosin regulatory light chain and controls the contraction of all muscle types. In vertebrates, different MLCKs function in smooth (MLCK1), skeletal (MLCK2), and cardiac (MLCK3) muscles. A fourth protein, MLCK4, has also been identified through comprehensive genome analysis although it has not been biochemically characterized. MLCK4 (or MYLK4 or SgK085) contains a single kinase domain near the C-terminus. The MLCK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271095 [Multi-domain]  Cd Length: 261  Bit Score: 78.42  E-value: 1.43e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYcQRTLREIKILLRFRHENIIGINDiirapTIEQMKD-VYIVQDLME 109
Cdd:cd14193  12 LGGGRFGQVHKCEEKSSGLKLAAKIIKARSQKEK-EEVKNEIEVMNQLNHANLIQLYD-----AFESRNDiVLVMEYVDG 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLL--KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL--NTTCDLKICDFGLARVADPDHDhtgfLT 185
Cdd:cd14193  86 GELFDRIidENYNLTELDTILFIKQICEGIQYMHQMYILHLDLKPENILCvsREANQVKIIDFGLARRYKPREK----LR 161
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 EYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDlnciinlkarnyll 265
Cdd:cd14193 162 VNFGTPEFLAPEV-VNYEFVSFPTDMWSLGVIAYMLLSGLSPFLGEDDNETLNNILACQWDFEDEE-------------- 226
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 66932916 266 slphknkvpwnrlFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14193 227 -------------FADISEEAKDFISKLLIKEKSWRMSASEALKHPWL 261
STKc_Mnk1 cd14174
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase ...
31-314 1.61e-16

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase signal-integrating kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK signal-integrating kinases (Mnks) are MAPK-activated protein kinases and is comprised by a group of four proteins, produced by alternative splicing from two genes (Mnk1 and Mnk2). The isoforms of Mnk1 (1a/1b) and Mnk2 (2a/2b) differ at their C-termini, with the a-form having a longer C-terminus containing a MAPK-binding region. All Mnks contain a catalytic kinase domain and a polybasic region at the N-terminus which binds importin and the eukaryotic initiation factor eIF4G. The best characterized Mnk substrate is eIF4G, whose phosphorylation may promote the export of certain mRNAs from the nucleus. Mnk also phosphorylate substrates that bind to AU-rich elements that regulate mRNA stability and translation. Mnks have also been implicated in tyrosine kinase receptor signaling, inflammation, and cell prolieration or survival. The Mnk subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271076 [Multi-domain]  Cd Length: 289  Bit Score: 78.92  E-value: 1.61e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYcQRTLREIKILLRFR-HENIIGIndiiraptIEQMKD---VYIVQD 106
Cdd:cd14174  10 LGEGAYAKVQGCVSLQNGKEYAVKIIEKNAGHSR-SRVFREVETLYQCQgNKNILEL--------IEFFEDdtrFYLVFE 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LME--TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT---CDLKICDFGLARVADPDHDHT 181
Cdd:cd14174  81 KLRggSILAHIQKRKHFNEREASRVVRDIASALDFLHTKGIAHRDLKPENILCESPdkvSPVKICDFDLGSGVKLNSACT 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLTEYVAT----RWYRAPEIML----NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhyldqlnhilgiLGSPSQEDLN 253
Cdd:cd14174 161 PITTPELTTpcgsAEYMAPEVVEvftdEATFYDKRCDLWSLGVILYIMLSGYPPFVGH------------CGTDCGWDRG 228
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 254 CIINLkARNYLLSLPHKNKVPwnrlFPNAD-----SKALDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd14174 229 EVCRV-CQNKLFESIQEGKYE----FPDKDwshisSEAKDLISKLLVRDAKERLSAAQVLQHPWVQ 289
PTZ00426 PTZ00426
cAMP-dependent protein kinase catalytic subunit; Provisional
24-254 1.84e-16

cAMP-dependent protein kinase catalytic subunit; Provisional


Pssm-ID: 173616 [Multi-domain]  Cd Length: 340  Bit Score: 79.25  E-value: 1.84e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   24 RYTNLSYI---GEGAYGMVCSA-YDNVNKVRVAIKKI--SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIeq 97
Cdd:PTZ00426  28 KYEDFNFIrtlGTGSFGRVILAtYKNEDFPPVAIKRFekSKIIKQKQVDHVFSERKILNYINHPFCVNLYGSFKDESY-- 105
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   98 mkdVYIVQD-LMETDLYKLLK-TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAD 175
Cdd:PTZ00426 106 ---LYLVLEfVIGGEFFTFLRrNKRFPNDVGCFYAAQIVLIFEYLQSLNIVYRDLKPENLLLDKDGFIKMTDFGFAKVVD 182
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  176 PDHDHTGFLTEYVatrwyrAPEIMLNSkGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL-GILGSPSQEDLNC 254
Cdd:PTZ00426 183 TRTYTLCGTPEYI------APEILLNV-GHGKAADWWTLGIFIYEILVGCPPFYANEPLLIYQKILeGIIYFPKFLDNNC 255
STKc_SRPK3 cd14218
Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3; STKs ...
16-313 1.87e-16

Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPK3 is highly expressed in the heart and skeletal muscles, and is controlled by a muscle-specific enhancer that is regulated by MEF2. It may play an important role in muscle development. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271120 [Multi-domain]  Cd Length: 365  Bit Score: 79.68  E-value: 1.87e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  16 GQVFDvgPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHqtYCQRTLREIKILLRFR--------HENIIGIN 87
Cdd:cd14218   5 GDLFN--GRYHVVRKLGWGHFSTVWLCWDIQRKRFVALKVVKSAVH--YTETAVDEIKLLKCVRdsdpsdpkRETIVQLI 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  88 DIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQHLSNDHICY--FLYQILRGLKYIHS-ANVLHRDLKPSNLLLNT----- 159
Cdd:cd14218  81 DDFKISGVNGVHVCMVLEVLGHQLLKWIIKSNYQGLPLPCVksILRQVLQGLDYLHTkCKIIHTDIKPENILMCVdegyv 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 160 -----------------------------------------TCDLKICDFGLARVAdpdHDHtgfLTEYVATRWYRAPEI 198
Cdd:cd14218 161 rrlaaeatiwqqagapppsgssvsfgasdflvnplepqnadKIRVKIADLGNACWV---HKH---FTEDIQTRQYRALEV 234
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 199 MLNSkGYTKSIDIWSVGCILAEMLSNRPIF---PGKHYL---DQLNHILGILGS--P--------SQE------DLNCII 256
Cdd:cd14218 235 LIGA-EYGTPADIWSTACMAFELATGDYLFephSGEDYTrdeDHIAHIVELLGDipPhfalsgrySREyfnrrgELRHIK 313
                       330       340       350       360       370
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 257 NLKARNYLLSLPHKNKVPWNRLfpnadSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14218 314 NLKHWGLYEVLVEKYEWPLEQA-----AQFTDFLLPMMEFLPEKRATAAQCLQHPWL 365
STKc_MLTK cd14060
Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated ...
32-230 2.07e-16

Catalytic domain of the Serine/Threonine Kinase, Mixed lineage kinase-Like mitogen-activated protein Triple Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLTK, also called zipper sterile-alpha-motif kinase (ZAK), contains a catalytic kinase domain and a leucine zipper. There are two alternatively-spliced variants, MLTK-alpha and MLTK-beta. MLTK-alpha contains a sterile-alpha-motif (SAM) at the C-terminus. MLTK regulates the c-Jun N-terminal kinase, extracellular signal-regulated kinase, p38 MAPK, and NF-kB pathways. ZAK is the MAP3K involved in the signaling cascade that leads to the ribotoxic stress response initiated by cellular damage due to Shiga toxins and ricin. It may also play a role in cell transformation and cancer development. MAP3Ks (MKKKs or MAPKKKs) phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals.The MLTK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270962 [Multi-domain]  Cd Length: 242  Bit Score: 77.69  E-value: 2.07e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  32 GEGAYGMVCSAYDNVNKVRVAIKKISPFEhqtycqrtlREIKILLRFRHENIIGINDIIraptIEQMKDVYIVQDLMETD 111
Cdd:cd14060   2 GGGSFGSVYRAIWVSQDKEVAVKKLLKIE---------KEAEILSVLSHRNIIQFYGAI----LEAPNYGIVTEYASYGS 68
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 112 LYKLLKT---QHLSNDHICYFLYQILRGLKYIHS---ANVLHRDLKPSNLLLNTTCDLKICDFGLARVadpdHDHTGFLT 185
Cdd:cd14060  69 LFDYLNSnesEEMDMDQIMTWATDIAKGMHYLHMeapVKVIHRDLKSRNVVIAADGVLKICDFGASRF----HSHTTHMS 144
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*
gi 66932916 186 eYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 230
Cdd:cd14060 145 -LVGTFPWMAPEV-IQSLPVSETCDTYSYGVVLWEMLTREVPFKG 187
STKc_Nek9 cd08221
Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA) ...
117-228 2.13e-16

Catalytic domain of the Protein Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 9; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek9, also called Nercc1, is primarily a cytoplasmic protein but can also localize in the nucleus. It is involved in modulating chromosome alignment and splitting during mitosis. It interacts with the gamma-tubulin ring complex and the Ran GTPase, and is implicated in microtubule organization. Nek9 associates with FACT (FAcilitates Chromatin Transcription) and modulates interphase progression. It also interacts with Nek6, and Nek7, during mitosis, resulting in their activation. Nek9 is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270860 [Multi-domain]  Cd Length: 256  Bit Score: 77.85  E-value: 2.13e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 117 KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDhtgFLTEYVATRWYRAP 196
Cdd:cd08221  94 KNQLFPEEVVLWYLYQIVSAVSHIHKAGILHRDIKTLNIFLTKADLVKLGDFGISKVLDSESS---MAESIVGTPYYMSP 170
                        90       100       110
                ....*....|....*....|....*....|..
gi 66932916 197 EIMLNSKgYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd08221 171 ELVQGVK-YNFKSDIWAVGCVLYELLTLKRTF 201
PHA03212 PHA03212
serine/threonine kinase US3; Provisional
34-324 2.21e-16

serine/threonine kinase US3; Provisional


Pssm-ID: 165478 [Multi-domain]  Cd Length: 391  Bit Score: 79.65  E-value: 2.21e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   34 GAYGMVCSAYDNVNKVRVAIKKispfehqtyCQR--TLREIKILLRFRHENIIGINDiirapTIEQMKDVYIVQDLMETD 111
Cdd:PHA03212 103 GAEGFAFACIDNKTCEHVVIKA---------GQRggTATEAHILRAINHPSIIQLKG-----TFTYNKFTCLILPRYKTD 168
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  112 LYKLLKTQHlsNDHICYFL---YQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLArvadpdhdhtGFLTEYV 188
Cdd:PHA03212 169 LYCYLAAKR--NIAICDILaieRSVLRAIQYLHENRIIHRDIKAENIFINHPGDVCLGDFGAA----------CFPVDIN 236
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  189 ATRWY--------RAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLD-------QLNHILGILGS-PSQEDL 252
Cdd:PHA03212 237 ANKYYgwagtiatNAPE-LLARDPYGPAVDIWSAGIVLFEMATCHDSLFEKDGLDgdcdsdrQIKLIIRRSGThPNEFPI 315
                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916  253 NCIINLKaRNYLLSLPHKNKVPWNR-LFPNADSKALD---LLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPI 324
Cdd:PHA03212 316 DAQANLD-EIYIGLAKKSSRKPGSRpLWTNLYELPIDleyLICKMLAFDAHHRPSAEALLDFAAFQDIPDPYPNPM 390
PTKc_Csk cd05082
Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the ...
31-223 2.34e-16

Catalytic domain of the Protein Tyrosine Kinase, C-terminal Src kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Csk catalyzes the tyr phosphorylation of the regulatory C-terminal tail of Src kinases, resulting in their inactivation. Csk is expressed in a wide variety of tissues. As a negative regulator of Src, Csk plays a role in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Csk is a cytoplasmic (or nonreceptor) PTK containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases, Csk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. In addition, Csk also shows Src-independent functions. It is a critical component in G-protein signaling, and plays a role in cytoskeletal reorganization and cell migration. The Csk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133213 [Multi-domain]  Cd Length: 256  Bit Score: 77.71  E-value: 2.34e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAydNVNKVRVAIKKIspfEHQTYCQRTLREIKILLRFRHENIIGINDIIraptIEQMKDVYIVQDLM-E 109
Cdd:cd05082  14 IGKGEFGDVMLG--DYRGNKVAVKCI---KNDATAQAFLAEASVMTQLRHSNLVQLLGVI----VEEKGGLYIVTEYMaK 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDhtgflTE 186
Cdd:cd05082  85 GSLVDYLRSRGrsvLGGDCLLKFSLDVCEAMEYLEGNNFVHRDLAARNVLVSEDNVAKVSDFGLTKEASSTQD-----TG 159
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 66932916 187 YVATRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05082 160 KLPVKW-TAPEALREKKFSTKS-DVWSFGILLWEIYS 194
PTKc_PDGFR cd05055
Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; ...
23-223 3.01e-16

Catalytic domain of the Protein Tyrosine Kinases, Platelet Derived Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The PDGFR subfamily consists of PDGFR alpha, PDGFR beta, KIT, CSF-1R, the mammalian FLT3, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. PDGFR kinase domains are autoinhibited by their juxtamembrane regions containing tyr residues. The binding to their ligands leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR subfamily receptors are important in the development of a variety of cells. PDGFRs are expressed in a many cells including fibroblasts, neurons, endometrial cells, mammary epithelial cells, and vascular smooth muscle cells. PDGFR signaling is critical in normal embryonic development, angiogenesis, and wound healing. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. CSF-1R signaling is critical in the regulation of macrophages and osteoclasts. Mammalian FLT3 plays an important role in the survival, proliferation, and differentiation of stem cells. The PDGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 133186 [Multi-domain]  Cd Length: 302  Bit Score: 78.30  E-value: 3.01e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  23 PRyTNLSY---IGEGAYGMV--CSAY-----DNVnkVRVAIKKISPFEHQTYCQRTLREIKILLRF-RHENIIginDIIR 91
Cdd:cd05055  33 PR-NNLSFgktLGAGAFGKVveATAYglsksDAV--MKVAVKMLKPTAHSSEREALMSELKIMSHLgNHENIV---NLLG 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  92 APTIEqmKDVYIVQDL-METDLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICD 167
Cdd:cd05055 107 ACTIG--GPILVITEYcCYGDLLNFLRRKResfLTLEDLLSFSYQVAKGMAFLASKNCIHRDLAARNVLLTHGKIVKICD 184
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 168 FGLARVADPDHDHTGFLTEYVATRWYrAPEIMLNSKgYTKSIDIWSVGCILAEMLS 223
Cdd:cd05055 185 FGLARDIMNDSNYVVKGNARLPVKWM-APESIFNCV-YTFESDVWSYGILLWEIFS 238
PTKc_VEGFR2 cd05103
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; ...
105-232 3.47e-16

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR2 (or Flk1) binds the ligands VEGFA, VEGFC, VEGFD and VEGFE. VEGFR2 signaling is implicated in all aspects of normal and pathological vascular endothelial cell biology. It induces a variety of cellular effects including migration, survival, and proliferation. It is critical in regulating embryonic vascular development and angiogenesis. VEGFR2 is the major signal transducer in pathological angiogenesis including cancer and diabetic retinopathy, and is a target for inhibition in cancer therapy. The carboxyl terminus of VEGFR2 plays an important role in its autophosphorylation and activation. VEGFR2 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270681 [Multi-domain]  Cd Length: 343  Bit Score: 78.48  E-value: 3.47e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETDLYK-LLKTQHLsndhICYFlYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR--VADPDHDHT 181
Cdd:cd05103 164 EEAGQEDLYKdFLTLEDL----ICYS-FQVAKGMEFLASRKCIHRDLAARNILLSENNVVKICDFGLARdiYKDPDYVRK 238
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 182 GflTEYVATRWYrAPEIMLNsKGYTKSIDIWSVGCILAEMLS-NRPIFPGKH 232
Cdd:cd05103 239 G--DARLPLKWM-APETIFD-RVYTIQSDVWSFGVLLWEIFSlGASPYPGVK 286
STKc_GAK cd14036
Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs ...
31-218 3.73e-16

Catalytic domain of the Serine/Threonine protein kinase, cyclin G-Associated Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GAK, also called auxilin-2, contains an N-terminal kinase domain that phosphorylates the mu subunits of adaptor protein (AP) 1 and AP2. In addition, it contains an auxilin-1-like domain structure consisting of PTEN-like, clathrin-binding, and J domains. Like auxilin-1, GAK facilitates Hsc70-mediated dissociation of clathrin from clathrin-coated vesicles. GAK is expressed ubiquitously and is enriched in the Golgi, unlike auxilin-1 which is nerve-specific. GAK also plays regulatory roles outside of clathrin-mediated membrane traffic including the maintenance of centrosome integrity and chromosome congression, neural patterning, survival of neurons, and immune responses through interaction with the interleukin 12 receptor. It also interacts with the androgen receptor, acting as a transcriptional coactivator, and its expression is significantly increased with the progression of prostate cancer. The GAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270938 [Multi-domain]  Cd Length: 282  Bit Score: 77.55  E-value: 3.73e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYcQRTLREIKILLRFR-HENIIginDIIRAPTI-----EQMKDVY-I 103
Cdd:cd14036   8 IAEGGFAFVYEAQDVGTGKEYALKRLLSNEEEKN-KAIIQEINFMKKLSgHPNIV---QFCSAASIgkeesDQGQAEYlL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLKT----QHLSNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNTTCDLKICDFGLAR--VAD 175
Cdd:cd14036  84 LTELCKGQLVDFVKKveapGPFSPDTVLKIFYQTCRAVQHMHKQSppIIHRDLKIENLLIGNQGQIKLCDFGSATteAHY 163
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 176 PDHDHT----GFLTEYV---ATRWYRAPEI--MLNSKGYTKSIDIWSVGCIL 218
Cdd:cd14036 164 PDYSWSaqkrSLVEDEItrnTTPMYRTPEMidLYSNYPIGEKQDIWALGCIL 215
STKc_GRK4_like cd05605
Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs ...
132-228 4.15e-16

Catalytic domain of G protein-coupled Receptor Kinase 4-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Members of the GRK4-like group include GRK4, GRK5, GRK6, and similar GRKs. They contain an N-terminal RGS homology (RH) domain and a catalytic domain, but lack a G protein betagamma-subunit binding domain. They are localized to the plasma membrane through post-translational lipid modification or direct binding to PIP2. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270756 [Multi-domain]  Cd Length: 285  Bit Score: 77.40  E-value: 4.15e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLArVADPDHDhtgFLTEYVATRWYRAPEIMLNSKgYTKSIDI 211
Cdd:cd05605 110 EITCGLEHLHSERIVYRDLKPENILLDDHGHVRISDLGLA-VEIPEGE---TIRGRVGTVGYMAPEVVKNER-YTFSPDW 184
                        90
                ....*....|....*..
gi 66932916 212 WSVGCILAEMLSNRPIF 228
Cdd:cd05605 185 WGLGCLIYEMIEGQAPF 201
PKc_PBS2_like cd06622
Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; ...
28-319 4.56e-16

Catalytic domain of fungal PBS2-like dual-specificity Mitogen-Activated Protein Kinase Kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. Members of this group include the MAPKKs Polymyxin B resistance protein 2 (PBS2) from Saccharomyces cerevisiae, Wis1 from Schizosaccharomyces pombe, and related proteins. PBS2 and Wis1 are components of stress-activated MAPK cascades in budding and fission yeast, respectively. PBS2 is the specific activator of the MAPK Hog1, which plays a central role in the response of budding yeast to stress including exposure to arsenite and hyperosmotic environments. Wis1 phosphorylates and activates the MAPK Sty1 (also called Spc1 or Phh1), which stimulates a transcriptional response to a wide range of cellular insults through the bZip transcription factors Atf1, Pcr1, and Pap1. The PBS2 subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132953 [Multi-domain]  Cd Length: 286  Bit Score: 77.58  E-value: 4.56e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIginDIIRAPTIEQMkdVYIVQDL 107
Cdd:cd06622   6 LDELGKGNYGSVYKVLHRPTGVTMAMKEIRLELDESKFNQIIMELDILHKAVSPYIV---DFYGAFFIEGA--VYMCMEY 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 MET-DLYKL----LKTQHLSNDHICYFLYQILRGLKYIHSA-NVLHRDLKPSNLLLNTTCDLKICDFGLarvadpdhdhT 181
Cdd:cd06622  81 MDAgSLDKLyaggVATEGIPEDVLRRITYAVVKGLKFLKEEhNIIHRDVKPTNVLVNGNGQVKLCDFGV----------S 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLTEYVAT-----RWYRAPE-----IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHY---LDQLNHIlgILGSPS 248
Cdd:cd06622 151 GNLVASLAKtnigcQSYMAPEriksgGPNQNPTYTVQSDVWSLGLSILEMALGRYPYPPETYaniFAQLSAI--VDGDPP 228
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 249 qedlnciinlkarnyllSLPhknkvpwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDP 319
Cdd:cd06622 229 -----------------TLP-----------SGYSDDAQDFVAKCLNKIPNRRPTYAQLLEHPWLVKYKNA 271
PKc_MEK1 cd06650
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
133-315 4.76e-16

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 1; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK1 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK1, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK1, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. MEK1 also plays a role in cell cycle control. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270816 [Multi-domain]  Cd Length: 319  Bit Score: 77.79  E-value: 4.76e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 133 ILRGLKYIHSAN-VLHRDLKPSNLLLNTTCDLKICDFGLA-RVADpdhdhtGFLTEYVATRWYRAPEiMLNSKGYTKSID 210
Cdd:cd06650 112 VIKGLTYLREKHkIMHRDVKPSNILVNSRGEIKLCDFGVSgQLID------SMANSFVGTRSYMSPE-RLQGTHYSVQSD 184
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 211 IWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSPSQEDLnciiNLKARNYLLSLPHKNKVPWNRLF---------- 279
Cdd:cd06650 185 IWSMGLSLVEMAVGRyPIPPPDAKELELMFGCQVEGDAAETPP----RPRTPGRPLSSYGMDSRPPMAIFelldyivnep 260
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 66932916 280 -PNADSKAL-----DLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
Cdd:cd06650 261 pPKLPSGVFslefqDFVNKCLIKNPAERADLKQLMVHAFIKR 302
STKc_SGK3 cd05604
Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced ...
28-299 6.44e-16

Catalytic domain of the Protein Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK3 (also called cytokine-independent survival kinase or CISK) is expressed in most tissues and is most abundant in the embryo and adult heart and spleen. It was originally discovered in a screen for antiapoptotic genes. It phosphorylates and inhibits the proapoptotic proteins, Bad and FKHRL1. SGK3 also regulates many transporters, ion channels, and receptors. It plays a critical role in hair follicle morphogenesis and hair cycling. The SGK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270755 [Multi-domain]  Cd Length: 326  Bit Score: 77.70  E-value: 6.44e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGMVCSAYDNVN----KVRVAIKKISPFEHQTycQRTLREIKILLR-FRHENIIGINdiiraPTIEQMKDVY 102
Cdd:cd05604   1 LKVIGKGSFGKVLLAKRKRDgkyyAVKVLQKKVILNRKEQ--KHIMAERNVLLKnVKHPFLVGLH-----YSFQTTDKLY 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
Cdd:cd05604  74 FVLDFVNGGelFFHLQRERSFPEPRARFYAAEIASALGYLHSINIVYRDLKPENILLDSQGHIVLTDFGLCKEGISNSDT 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 TgflTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsQEDLNCI--INL 258
Cdd:cd05604 154 T---TTFCGTPEYLAPEV-IRKQPYDNTVDWWCLGSVLYEMLYGLPPFYCRDTAEMYENIL-------HKPLVLRpgISL 222
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 259 KARNYLLSLPHKNkvPWNRLFPNADSKAL------------DLLDKMLT--FNPH 299
Cdd:cd05604 223 TAWSILEELLEKD--RQLRLGAKEDFLEIknhpffesinwtDLVQKKIPppFNPN 275
STKc_SGK cd05575
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; ...
132-298 7.69e-16

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGKs are activated by insulin and growth factors via phosphoinositide 3-kinase and PDK1. They activate ion channels, ion carriers, and the Na-K-ATPase, as well as regulate the activity of enzymes and transcription factors. SGKs play important roles in transport, hormone release, neuroexcitability, cell proliferation, and apoptosis. There are three isoforms of SGK, named SGK1, SGK2, and SGK3 (also called cytokine-independent survival kinase CISK). The SGK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270727 [Multi-domain]  Cd Length: 323  Bit Score: 77.36  E-value: 7.69e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgflTEYVATRWYRAPEImLNSKGYTKSIDI 211
Cdd:cd05575 104 EIASALGYLHSLNIIYRDLKPENILLDSQGHVVLTDFGLCKEGIEPSDTT---STFCGTPEYLAPEV-LRKQPYDRTVDW 179
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 212 WSVGCILAEMLSNRPIFPGKHYLDQLNhilGILGSPSQEDLNciINLKARNYLLSLPHKNKVpwNRLFPNADSKAL---- 287
Cdd:cd05575 180 WCLGAVLYEMLYGLPPFYSRDTAEMYD---NILHKPLRLRTN--VSPSARDLLEGLLQKDRT--KRLGSGNDFLEIknhs 252
                       170       180
                ....*....|....*....|.
gi 66932916 288 --------DLLDKMLT--FNP 298
Cdd:cd05575 253 ffrpinwdDLEAKKIPppFNP 273
PTKc_Fer cd05085
Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; ...
31-223 8.55e-16

Catalytic domain of the Protein Tyrosine Kinase, Fer; Protein Tyrosine Kinase (PTK) family; Fer kinase; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fer kinase is a member of the Fes subfamily of proteins which are cytoplasmic (or nonreceptor) tyr kinases containing an N-terminal region with FCH (Fes/Fer/CIP4 homology) and coiled-coil domains, followed by a SH2 domain, and a C-terminal catalytic domain. Fer kinase is expressed in a wide variety of tissues, and is found to reside in both the cytoplasm and the nucleus. It plays important roles in neuronal polarization and neurite development, cytoskeletal reorganization, cell migration, growth factor signaling, and the regulation of cell-cell interactions mediated by adherens junctions and focal adhesions. Fer kinase also regulates cell cycle progression in malignant cells.


Pssm-ID: 270668 [Multi-domain]  Cd Length: 251  Bit Score: 76.20  E-value: 8.55e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNvNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLMET 110
Cdd:cd05085   4 LGKGNFGEVYKGTLK-DKTPVAVKTCKEDLPQELKIKFLSEARILKQYDHPNIVKLIGVC-----TQRQPIYIVMELVPG 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 -DLYKLL--KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpDHDHTGFLTEY 187
Cdd:cd05085  78 gDFLSFLrkKKDELKTKQLVKFSLDAAAGMAYLESKNCIHRDLAARNCLVGENNALKISDFGMSRQED-DGVYSSSGLKQ 156
                       170       180       190
                ....*....|....*....|....*....|....*.
gi 66932916 188 VATRWyRAPEiMLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05085 157 IPIKW-TAPE-ALNYGRYSSESDVWSFGILLWETFS 190
STKc_SBK1 cd13987
Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the ...
31-310 8.71e-16

Catalytic domain of the Serine/Threonine kinase, SH3 Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SBK1, also called BSK146, is predominantly expressed in the brain. Its expression is increased in the developing brain during the late embryonic stage, coinciding with dramatic neuronal proliferation, migration, and maturation. SBK1 may play an important role in regulating brain development. The SBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270889 [Multi-domain]  Cd Length: 259  Bit Score: 76.21  E-value: 8.71e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISpfEHQTYCQRTLREIKILLRFR-HENIIGINDIirapTIEQMkDVYI-VQDLM 108
Cdd:cd13987   1 LGEGTYGKVLLAVHKGSGTKMALKFVP--KPSTKLKDFLREYNISLELSvHPHIIKTYDV----AFETE-DYYVfAQEYA 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLnttCD-----LKICDFGLARvadpdhdHT 181
Cdd:cd13987  74 PYgDLFSIIPPQVgLPEERVKRCAAQLASALDFMHSKNLVHRDIKPENVLL---FDkdcrrVKLCDFGLTR-------RV 143
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLTEYVAtRW--YRAPEI--MLNSKGYT--KSIDIWSVGCILAEMLSNRPifpgkhyldqlnhilgilgsPSQEDLncI 255
Cdd:cd13987 144 GSTVKRVS-GTipYTAPEVceAKKNEGFVvdPSIDVWAFGVLLFCCLTGNF--------------------PWEKAD--S 200
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 256 INLKARNYLLSLPHKNKVP---WNRLFPnadsKALDLLDKMLTFNPHKRIEVEQALAH 310
Cdd:cd13987 201 DDQFYEEFVRWQKRKNTAVpsqWRRFTP----KALRMFKKLLAPEPERRCSIKEVFKY 254
STKc_Sid2p_like cd05600
Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases; STKs catalyze the ...
115-314 1.07e-15

Catalytic domain of Fungal Sid2p-like Protein Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This group contains fungal kinases including Schizosaccharomyces pombe Sid2p and Saccharomyces cerevisiae Dbf2p. Group members show similarity to NDR kinases in that they contain an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Sid2p plays a crucial role in the septum initiation network (SIN) and in the initiation of cytokinesis. Dbf2p is important in regulating the mitotic exit network (MEN) and in cytokinesis. The Sid2p-like group is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270751 [Multi-domain]  Cd Length: 386  Bit Score: 77.38  E-value: 1.07e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 115 LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-----------------RVADPD 177
Cdd:cd05600 102 LNNSGILSEEHARFYIAEMFAAISSLHQLGYIHRDLKPENFLIDSSGHIKLTDFGLAsgtlspkkiesmkirleEVKNTA 181
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HDHtgfLTEY--------------------VATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGkhylDQL 237
Cdd:cd05600 182 FLE---LTAKerrniyramrkedqnyansvVGSPDYMAPE-VLRGEGYDLTVDYWSLGCILFECLVGFPPFSG----STP 253
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 238 NHILgilgspsqedlnciINLKARNYLLSLPHKNKVPWNRLFPNadsKALDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd05600 254 NETW--------------ANLYHWKKTLQRPVYTDPDLEFNLSD---EAWDLITKLITDPQDRLQSPEQIKNHPFFK 313
PTKc_Jak1_rpt2 cd05079
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the ...
31-223 1.08e-15

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak1 is widely expressed in many tissues. Many cytokines are dependent on Jak1 for signaling, including those that use the shared receptor subunits common gamma chain (IL-2, IL-4, IL-7, IL-9, IL-15, IL-21) and gp130 (IL-6, IL-11, oncostatin M, G-CSF, and IFNs, among others). The many varied interactions of Jak1 and its ubiquitous expression suggest many biological roles. Jak1 is important in neurological development, as well as in lymphoid development and function. It also plays a role in the pathophysiology of cardiac hypertrophy and heart failure. A mutation in the ATP-binding site of Jak1 was identified in a human uterine leiomyosarcoma cell line, resulting in defective cytokine induction and antigen presentation, thus allowing the tumor to evade the immune system. Jak1 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Jak1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173644 [Multi-domain]  Cd Length: 284  Bit Score: 76.51  E-value: 1.08e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMV--CSaYD---NVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENII------------GINDIIRAP 93
Cdd:cd05079  12 LGEGHFGKVelCR-YDpegDNTGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVkykgictedggnGIKLIMEFL 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  94 TIEQMKDvYIVQDLMETDLYKLLKtqhlsndhicyFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV 173
Cdd:cd05079  91 PSGSLKE-YLPRNKNKINLKQQLK-----------YAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIGDFGLTKA 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 ADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05079 159 IETDKEYYTVKDDLDSPVFWYAPECLIQSKFYIAS-DVWSFGVTLYELLT 207
PTKc_Fyn cd05070
Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the ...
31-258 1.14e-15

Catalytic domain of the Protein Tyrosine Kinase, Fyn; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Fyn and Yrk are members of the Src subfamily of proteins, which are cytoplasmic (or non-receptor) PTKs. Fyn, together with Lck, plays a critical role in T-cell signal transduction by phosphorylating ITAM (immunoreceptor tyr activation motif) sequences on T-cell receptors, ultimately leading to the proliferation and differentiation of T-cells. In addition, Fyn is involved in the myelination of neurons, and is implicated in Alzheimer's and Parkinson's diseases. Src kinases contain an N-terminal SH4 domain with a myristoylation site, followed by SH3 and SH2 domains, a tyr kinase domain, and a regulatory C-terminal region containing a conserved tyr. They are activated by autophosphorylation at the tyr kinase domain, but are negatively regulated by phosphorylation at the C-terminal tyr by Csk (C-terminal Src Kinase). The Fyn/Yrk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase.


Pssm-ID: 270655 [Multi-domain]  Cd Length: 274  Bit Score: 76.26  E-value: 1.14e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNkVRVAIKKISPFEHQTycQRTLREIKILLRFRHENIIGINDII-RAPtieqmkdVYIVQDLME 109
Cdd:cd05070  17 LGNGQFGEVWMGTWNGN-TKVAIKTLKPGTMSP--ESFLEEAQIMKKLKHDKLVQLYAVVsEEP-------IYIVTEYMS 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 T----DLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpDHDHTGFLT 185
Cdd:cd05070  87 KgsllDFLKDGEGRALKLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIE-DNEYTARQG 165
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916 186 EYVATRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLSN-RPIFPGKHYLDQLNHILGILGSPSQEDlnCIINL 258
Cdd:cd05070 166 AKFPIKW-TAPEAALYGRFTIKS-DVWSFGILLTELVTKgRVPYPGMNNREVLEQVERGYRMPCPQD--CPISL 235
STKc_cPKC cd05587
Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; ...
106-230 1.26e-15

Catalytic domain of the Serine/Threonine Kinase, Classical (or Conventional) Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. cPKCs are potent kinases for histones, myelin basic protein, and protamine. They depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. cPKCs contain a calcium-binding C2 region in their regulatory domain. There are four cPKC isoforms, named alpha, betaI, betaII, and gamma. PKC-gamma is mainly expressed in neuronal tissues. It plays a role in protection from ischemia. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The cPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270739 [Multi-domain]  Cd Length: 320  Bit Score: 76.66  E-value: 1.26e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMetdlYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR--VADPDHDHTgf 183
Cdd:cd05587  83 DLM----YHIQQVGKFKEPVAVFYAAEIAVGLFFLHSKGIIYRDLKLDNVMLDAEGHIKIADFGMCKegIFGGKTTRT-- 156
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 184 lteYVATRWYRAPEIMLNsKGYTKSIDIWSVGCILAEMLSNRPIFPG 230
Cdd:cd05587 157 ---FCGTPDYIAPEIIAY-QPYGKSVDWWAYGVLLYEMLAGQPPFDG 199
PTKc_Itk cd05112
Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs ...
31-223 1.29e-15

Catalytic domain of the Protein Tyrosine Kinase, Interleukin-2-inducible T-cell Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Itk, also known as Tsk or Emt, is a member of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Itk contains the Tec homology (TH) domain containing one proline-rich region and a zinc-binding region. Itk is expressed in T-cells and mast cells, and is important in their development and differentiation. Of the three Tec kinases expressed in T-cells, Itk plays the predominant role in T-cell receptor (TCR) signaling. It is activated by phosphorylation upon TCR crosslinking and is involved in the pathway resulting in phospholipase C-gamma1 activation and actin polymerization. It also plays a role in the downstream signaling of the T-cell costimulatory receptor CD28, the T-cell surface receptor CD2, and the chemokine receptor CXCR4. In addition, Itk is crucial for the development of T-helper(Th)2 effector responses. The Itk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133243 [Multi-domain]  Cd Length: 256  Bit Score: 75.76  E-value: 1.29e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYdNVNKVRVAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINDII--RAPtieqmkdVYIVQDLM 108
Cdd:cd05112  12 IGSGQFGLVHLGY-WLNKDKVAIKTIR--EGAMSEEDFIEEAEVMMKLSHPKLVQLYGVCleQAP-------ICLVFEFM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ETD-LYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLT 185
Cdd:cd05112  82 EHGcLSDYLRTQRglFSAETLLGMCLDVCEGMAYLEEASVIHRDLAARNCLVGENQVVKVSDFGMTRFVLDDQYTSSTGT 161
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 66932916 186 EYvATRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05112 162 KF-PVKW-SSPEVFSFSRYSSKS-DVWSFGVLMWEVFS 196
STKc_PAK4 cd06657
Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the ...
27-320 1.32e-15

Catalytic domain of the Serine/Threonine Kinase, p21-activated kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PAK4 regulates cell morphology and cytoskeletal organization. It is essential for embryonic viability and proper neural development. Mice lacking PAK4 die due to defects in the fetal heart. In addition, their spinal cord motor neurons showed failure to differentiate and migrate. PAK4 also plays a role in cell survival and tumorigenesis. It is overexpressed in many primary tumors including colon, esophageal, and mammary tumors. PAK4 has also been implicated in viral and bacterial infection pathways. PAK4 belongs to the group II PAKs, which contain a PBD (p21-binding domain) and a C-terminal catalytic domain, but do not harbor an AID (autoinhibitory domain) or SH3 binding sites. PAKs are Rho family GTPase-regulated kinases that serve as important mediators in the function of Cdc42 (cell division cycle 42) and Rac. The PAK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132988 [Multi-domain]  Cd Length: 292  Bit Score: 76.21  E-value: 1.32e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  27 NLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpFEHQTYCQRTLREIKILLRFRHENIIgindiiraptieQMKDVYIVQD 106
Cdd:cd06657  24 NFIKIGEGSTGIVCIATVKSSGKLVAVKKMD-LRKQQRRELLFNEVVIMRDYQHENVV------------EMYNSYLVGD 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 ----LME----TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDH 178
Cdd:cd06657  91 elwvVMEflegGALTDIVTHTRMNEEQIAAVCLAVLKALSVLHAQGVIHRDIKSDSILLTHDGRVKLSDFGFCAQVSKEV 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 DHTGFLteyVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGilgspsqedlnciiNL 258
Cdd:cd06657 171 PRRKSL---VGTPYWMAPE-LISRLPYGPEVDIWSLGIMVIEMVDGEPPYFNEPPLKAMKMIRD--------------NL 232
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 259 KARnyllsLPHKNKV-PWNRLFpnadskaldlLDKMLTFNPHKRIEVEQALAHPYLEQYYDPS 320
Cdd:cd06657 233 PPK-----LKNLHKVsPSLKGF----------LDRLLVRDPAQRATAAELLKHPFLAKAGPPS 280
PTKc_Ack_like cd05040
Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs ...
31-223 1.41e-15

Catalytic domain of the Protein Tyrosine Kinase, Activated Cdc42-associated kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily includes Ack1, thirty-eight-negative kinase 1 (Tnk1), and similar proteins. They are cytoplasmic (or nonreceptor) PTKs containing an N-terminal catalytic domain, an SH3 domain, a Cdc42-binding CRIB domain, and a proline-rich region. They are mainly expressed in brain and skeletal tissues and are involved in the regulation of cell adhesion and growth, receptor degradation, and axonal guidance. Ack1 is also associated with androgen-independent prostate cancer progression. Tnk1 regulates TNFalpha signaling and may play an important role in cell death. The Ack-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270636 [Multi-domain]  Cd Length: 258  Bit Score: 75.46  E-value: 1.41e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSA-YDNVN--KVRVAIKKISP--FEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEqmkdvyIVQ 105
Cdd:cd05040   3 LGDGSFGVVRRGeWTTPSgkVIQVAVKCLKSdvLSQPNAMDDFLKEVNAMHSLDHPNLIRLYGVVLSSPLM------MVT 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMEtdLYKLLKTQHLSNDH-----ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
Cdd:cd05040  77 ELAP--LGSLLDRLRKDQGHflistLCDYAVQIANGMAYLESKRFIHRDLAARNILLASKDKVKIGDFGLMRALPQNEDH 154
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 tgflteYVATR-------WYrAPEiMLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05040 155 ------YVMQEhrkvpfaWC-APE-SLKTRKFSHASDVWMFGVTLWEMFT 196
PTKc_VEGFR3 cd05102
Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; ...
91-223 1.49e-15

Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR3 (or Flt4) preferentially binds the ligands VEGFC and VEGFD. VEGFR3 is essential for lymphatic endothelial cell (EC) development and function. It has been shown to regulate adaptive immunity during corneal transplantation. VEGFR3 is upregulated on blood vascular ECs in pathological conditions such as vascular tumors and the periphery of solid tumors. It plays a role in cancer progression and lymph node metastasis. Missense mutations in the VEGFR3 gene are associated with primary human lymphedema. VEGFR3 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270680 [Multi-domain]  Cd Length: 336  Bit Score: 76.56  E-value: 1.49e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  91 RAPTIEQMKDVYIVQDLMEtdlykllktqhlsnDHICYFlYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGL 170
Cdd:cd05102 154 TNQPRQEVDDLWQSPLTME--------------DLICYS-FQVARGMEFLASRKCIHRDLAARNILLSENNVVKICDFGL 218
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 171 AR--VADPDHDHTGflTEYVATRWYrAPEIMLNsKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05102 219 ARdiYKDPDYVRKG--SARLPLKWM-APESIFD-KVYTTQSDVWSFGVLLWEIFS 269
STKc_MST3 cd06641
Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs ...
25-226 1.53e-15

Catalytic domain of the Serine/Threonine Kinase, Mammalian Ste20-like protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MST3 phosphorylates the STK NDR and may play a role in cell cycle progression and cell morphology. It may also regulate paxillin and consequently, cell migration. MST3 is present in human placenta, where it plays an essential role in the oxidative stress-induced apoptosis of trophoblasts in normal spontaneous delivery. Dysregulation of trophoblast apoptosis may result in pregnancy complications such as preeclampsia and intrauterine growth retardation. The MST3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270809 [Multi-domain]  Cd Length: 277  Bit Score: 75.88  E-value: 1.53e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGIndiiRAPTIEQMKDVYIV 104
Cdd:cd06641   6 FTKLEKIGKGSFGEVFKGIDNRTQKVVAIKIIDLEEAEDEIEDIQQEITVLSQCDSPYVTKY----YGSYLKDTKLWIIM 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-RVADPDHDHTGF 183
Cdd:cd06641  82 EYLGGGSALDLLEPGPLDETQIATILREILKGLDYLHSEKKIHRDIKAANVLLSEHGEVKLADFGVAgQLTDTQIKRN*F 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 66932916 184 lteyVATRWYRAPEIMLNSkGYTKSIDIWSVGCILAEMLSNRP 226
Cdd:cd06641 162 ----VGTPFWMAPEVIKQS-AYDSKADIWSLGITAIELARGEP 199
PK_Unc-89_rpt1 cd14109
Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein ...
69-313 1.56e-15

Pseudokinase domain, first repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The pseudokinase domain may function as a regulatory domain or a protein interaction domain. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271011 [Multi-domain]  Cd Length: 255  Bit Score: 75.24  E-value: 1.56e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  69 LREIKILLRFRHENIIGINDIIRaptiEQMKDVYIVQDLMET-DLYK---LLKTQHLSNDHICYFLYQILRGLKYIHSAN 144
Cdd:cd14109  44 MREVDIHNSLDHPNIVQMHDAYD----DEKLAVTVIDNLASTiELVRdnlLPGKDYYTERQVAVFVRQLLLALKHMHDLG 119
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 145 VLHRDLKPSNLLLNTTcDLKICDFGLARVADPDHDHTGFL--TEYVatrwyrAPEImLNSKGYTKSIDIWSVGCILAEML 222
Cdd:cd14109 120 IAHLDLRPEDILLQDD-KLKLADFGQSRRLLRGKLTTLIYgsPEFV------SPEI-VNSYPVTLATDMWSVGVLTYVLL 191
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 223 SNrpifpgkhyldqLNHILGIlgspsqEDLNCIINLKARNYLLslphkNKVPWNrlfpNADSKALDLLDKMLTFNPHKRI 302
Cdd:cd14109 192 GG------------ISPFLGD------NDRETLTNVRSGKWSF-----DSSPLG----NISDDARDFIKKLLVYIPESRL 244
                       250
                ....*....|.
gi 66932916 303 EVEQALAHPYL 313
Cdd:cd14109 245 TVDEALNHPWF 255
STKc_LRRK cd14000
Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the ...
31-301 1.58e-15

Catalytic domain of the Serine/Threonine kinase, Leucine-Rich Repeat Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. Vertebrates contain two members, LRRK1 and LRRK2, which show complementary expression in the brain. Mutations in LRRK2 are linked to both familial and sporadic forms of Parkinson's disease. The normal roles of LRRKs are not clearly defined. They may be involved in mitogen-activated protein kinase (MAPK) pathways, protein translation control, programmed cell death pathways, and cytoskeletal dynamics. The LRRK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270902 [Multi-domain]  Cd Length: 275  Bit Score: 75.73  E-value: 1.58e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPF-----------------EHQTYCQRTLR-EIKILLRFRHENIIGINDIIRA 92
Cdd:cd14000   2 LGDGGFGSVYRASYKGEPVAVKIFNKHTSsnfanvpadtmlrhlraTDAMKNFRLLRqELTVLSHLHHPSIVYLLGIGIH 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  93 PTIeqmkdvyIVQDLM-ETDLYKLLKTQHLSNDHICYFL-----YQILRGLKYIHSANVLHRDLKPSNLLL-----NTTC 161
Cdd:cd14000  82 PLM-------LVLELApLGSLDHLLQQDSRSFASLGRTLqqriaLQVADGLRYLHSAMIIYRDLKSHNVLVwtlypNSAI 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 162 DLKICDFGLARVAdpdhDHTGFLTeYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL 241
Cdd:cd14000 155 IIKIADYGISRQC----CRMGAKG-SEGTPGFRAPEIARGNVIYNEKVDVFSFGMLLYEILSGGAPMVGHLKFPNEFDIH 229
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 242 GilGSPSqedlnciinlkarnyllSLPHKNKVPWNRLfpnadskaLDLLDKMLTFNPHKR 301
Cdd:cd14000 230 G--GLRP-----------------PLKQYECAPWPEV--------EVLMKKCWKENPQQR 262
STKc_SGK2 cd05603
Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; ...
31-241 1.75e-15

Catalytic domain of the Serine/Threonine Kinase, Serum- and Glucocorticoid-induced Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SGK2 shows a more restricted distribution than SGK1 and is most abundantly expressed in epithelial tissues including kidney, liver, pancreas, and the choroid plexus of the brain. In vitro cellular assays show that SGK2 can stimulate the activity of ion channels, the glutamate transporter EEAT4, and the glutamate receptors, GluR6 and GLUR1. The SGK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270754 [Multi-domain]  Cd Length: 321  Bit Score: 76.16  E-value: 1.75e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAY----DNVNKVRVAIKK-ISPFEHQTYcqrTLREIKILLR-FRHENIIGINDIIRAPtieqmKDVYIV 104
Cdd:cd05603   3 IGKGSFGKVLLAKrkcdGKFYAVKVLQKKtILKKKEQNH---IMAERNVLLKnLKHPFLVGLHYSFQTS-----EKLYFV 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTg 182
Cdd:cd05603  75 LDYVNGGelFFHLQRERCFLEPRARFYAAEVASAIGYLHSLNIIYRDLKPENILLDCQGHVVLTDFGLCKEGMEPEETT- 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 183 flTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL 241
Cdd:cd05603 154 --STFCGTPEYLAPEV-LRKEPYDRTVDWWCLGAVLYEMLYGLPPFYSRDVSQMYDNIL 209
STKc_Nek7 cd08229
Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase ...
31-250 2.26e-15

Catalytic domain of the Serine/Threonine Kinase, Never In Mitosis gene A (NIMA)-related kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Nek7 is required for mitotic spindle formation and cytokinesis. It is enriched in the centrosome and is critical for microtubule nucleation. Nek7 is activated by Nek9 during mitosis, and may regulate the p70 ribosomal S6 kinase. It is one in a family of 11 different Neks (Nek1-11) that are involved in cell cycle control. The Nek family is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270866 [Multi-domain]  Cd Length: 292  Bit Score: 75.45  E-value: 2.26e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRT--LREIKILLRFRHENIIGINdiirAPTIEQmKDVYIVQDLM 108
Cdd:cd08229  32 IGRGQFSEVYRATCLLDGVPVALKKVQIFDLMDAKARAdcIKEIDLLKQLNHPNVIKYY----ASFIED-NELNIVLELA 106
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLLK-----TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpdhDHTG 182
Cdd:cd08229 107 DAgDLSRMIKhfkkqKRLIPEKTVWKYFVQLCSALEHMHSRRVMHRDIKPANVFITATGVVKLGDLGLGRFFS---SKTT 183
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 183 FLTEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLS----------------------NRPIFPGKHYLDQLNHI 240
Cdd:cd08229 184 AAHSLVGTPYYMSPE-RIHENGYNFKSDIWSLGCLLYEMAAlqspfygdkmnlyslckkieqcDYPPLPSDHYSEELRQL 262
                       250
                ....*....|
gi 66932916 241 LGILGSPSQE 250
Cdd:cd08229 263 VNMCINPDPE 272
PLN00034 PLN00034
mitogen-activated protein kinase kinase; Provisional
31-315 2.84e-15

mitogen-activated protein kinase kinase; Provisional


Pssm-ID: 215036 [Multi-domain]  Cd Length: 353  Bit Score: 76.02  E-value: 2.84e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVQDLMET 110
Cdd:PLN00034  82 IGSGAGGTVYKVIHRPTGRLYALKVIYGNHEDTVRRQICREIEILRDVNHPNVVKCHDMF-----DHNGEIQVLLEFMDG 156
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  111 DLyklLKTQHLSNDH-ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV----ADPdhdhtgfLT 185
Cdd:PLN00034 157 GS---LEGTHIADEQfLADVARQILSGIAYLHRRHIVHRDIKPSNLLINSAKNVKIADFGVSRIlaqtMDP-------CN 226
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  186 EYVATRWYRAPEIM---LNSKGYTK-SIDIWSVGCILAEMLSNRpiFPgkhyldqlnhilgiLGSPSQED---LNCIInl 258
Cdd:PLN00034 227 SSVGTIAYMSPERIntdLNHGAYDGyAGDIWSLGVSILEFYLGR--FP--------------FGVGRQGDwasLMCAI-- 288
                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916  259 karnyllSLPHKNKVPwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
Cdd:PLN00034 289 -------CMSQPPEAP-----ATASREFRHFISCCLQREPAKRWSAMQLLQHPFILR 333
STKc_MLK4 cd14146
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the ...
31-223 2.92e-15

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK4 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. The specific function of MLK4 is yet to be determined. Mutations in the kinase domain of MLK4 have been detected in colorectal cancers. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271048 [Multi-domain]  Cd Length: 268  Bit Score: 75.07  E-value: 2.92e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLR-EIKILLRFRHENIIGINDI-IRAP----TIEQMKDVYIV 104
Cdd:cd14146   2 IGVGGFGKVYRATWKGQEVAVKAARQDPDEDIKATAESVRqEAKLFSMLRHPNIIKLEGVcLEEPnlclVMEFARGGTLN 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETDLYKLLKTQHLSNDHICY-FLYQILRGLKYIHS---ANVLHRDLKPSNLLL------NTTCD--LKICDFGLAR 172
Cdd:cd14146  82 RALAAANAAPGPRRARRIPPHILVnWAVQIARGMLYLHEeavVPILHRDLKSSNILLlekiehDDICNktLKITDFGLAR 161
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 173 VAdpdHDHTGFLTeyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd14146 162 EW---HRTTKMSA--AGTYAWMAPEV-IKSSLFSKGSDIWSYGVLLWELLT 206
STKc_myosinIIIA_N cd06638
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze ...
11-240 3.13e-15

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIA myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIA myosin is highly expressed in retina and in inner ear hair cells. It is localized to the distal ends of actin-bundled structures. Mutations in human myosin IIIA are responsible for progressive nonsyndromic hearing loss. Human myosin IIIA possesses ATPase and kinase activities, and the ability to move actin filaments in a motility assay. It may function as a cellular transporter capable of moving along actin bundles in sensory cells. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. Class III myosins may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. In photoreceptor cells, they may also function as cargo carriers during light-dependent translocation of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132969 [Multi-domain]  Cd Length: 286  Bit Score: 75.05  E-value: 3.13e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  11 PEMVRGQVFDVGPRYTN----LSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTycQRTLREIKILLRFR-HENIIG 85
Cdd:cd06638   2 PLSGKTIIFDSFPDPSDtweiIETIGKGTYGKVFKVLNKKNGSKAAVKILDPIHDID--EEIEAEYNILKALSdHPNVVK 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  86 INDIIRAPTIEQMKDVYIVQDLME----TDLYK--LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT 159
Cdd:cd06638  80 FYGMYYKKDVKNGDQLWLVLELCNggsvTDLVKgfLKRGERMEEPIIAYILHEALMGLQHLHVNKTIHRDVKGNNILLTT 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 160 TCDLKICDFGL-ARVADPDHDHtgflTEYVATRWYRAPEIM-----LNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHY 233
Cdd:cd06638 160 EGGVKLVDFGVsAQLTSTRLRR----NTSVGTPFWMAPEVIaceqqLDST-YDARCDVWSLGITAIELGDGDPPLADLHP 234

                ....*..
gi 66932916 234 LDQLNHI 240
Cdd:cd06638 235 MRALFKI 241
PKc_MKK7 cd06618
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
27-326 3.37e-15

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 7; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK7 is a dual-specificity PK that phosphorylates and activates its downstream target, c-Jun N-terminal kinase (JNK), on specific threonine and tyrosine residues. Although MKK7 is capable of dual phosphorylation, it prefers to phosphorylate the threonine residue of JNK. Thus, optimal activation of JNK requires both MKK4 and MKK7. MKK7 is primarily activated by cytokines. MKK7 is essential for liver formation during embryogenesis. It plays roles in G2/M cell cycle arrest and cell growth. In addition, it is involved in the control of programmed cell death, which is crucial in oncogenesis, cancer chemoresistance, and antagonism to TNFalpha-induced killing, through its inhibition by Gadd45beta and the subsequent suppression of the JNK cascade. The MKK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270791 [Multi-domain]  Cd Length: 295  Bit Score: 75.10  E-value: 3.37e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  27 NLSYIGEGAYGMVCSA-YDNVNKVrVAIKKISPFEHQTYCQRTLREIKILLRfRHEniigindiirAPTIEQM------- 98
Cdd:cd06618  19 NLGEIGSGTCGQVYKMrHKKTGHV-MAVKQMRRSGNKEENKRILMDLDVVLK-SHD----------CPYIVKCygyfitd 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLMETDLYKLLK-TQHLSNDHIC-YFLYQILRGLKYIHSA-NVLHRDLKPSNLLLNTTCDLKICDFGLArvad 175
Cdd:cd06618  87 SDVFICMELMSTCLDKLLKrIQGPIPEDILgKMTVSIVKALHYLKEKhGVIHRDVKPSNILLDESGNVKLCDFGIS---- 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 176 pdhdhtGFLTEYVA-TR-----WYRAPE-IMLNSKG-YTKSIDIWSVGCILAEMLSNRPIFPG-KHYLDQLNHILgilgs 246
Cdd:cd06618 163 ------GRLVDSKAkTRsagcaAYMAPErIDPPDNPkYDIRADVWSLGISLVELATGQFPYRNcKTEFEVLTKIL----- 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 247 psQEDLNCIInlkarnyllslPHKNKVPwnrLFpnadskaLDLLDKMLTFNPHKRIEVEQALAHPYLeQYYDPSDEPIAE 326
Cdd:cd06618 232 --NEEPPSLP-----------PNEGFSP---DF-------CSFVDLCLTKDHRYRPKYRELLQHPFI-RRYETAEVDVAS 287
STKc_MAST cd05609
Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine ...
128-230 3.76e-15

Catalytic domain of the Protein Serine/Threonine Kinase, Microtubule-associated serine/threonine kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAST kinases contain an N-terminal domain of unknown function, a central catalytic domain, and a C-terminal PDZ domain that mediates protein-protein interactions. There are four mammalian MAST kinases, named MAST1-MAST4. MAST1 is also called syntrophin-associated STK (SAST) while MAST2 is also called MAST205. MAST kinases are cytoskeletal associated kinases of unknown function that are also expressed at neuromuscular junctions and postsynaptic densities. MAST1, MAST2, and MAST3 bind and phosphorylate the tumor suppressor PTEN, and may contribute to the regulation and stabilization of PTEN. MAST2 is involved in the regulation of the Fc-gamma receptor of the innate immune response in macrophages, and may also be involved in the regulation of the Na+/H+ exchanger NHE3. The MAST kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270760 [Multi-domain]  Cd Length: 280  Bit Score: 74.75  E-value: 3.76e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 128 YFLYQILrGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVA-----------DPDHDHTGFLTEYV-ATRWYRA 195
Cdd:cd05609 105 YFAETVL-ALEYLHSYGIVHRDLKPDNLLITSMGHIKLTDFGLSKIGlmslttnlyegHIEKDTREFLDKQVcGTPEYIA 183
                        90       100       110
                ....*....|....*....|....*....|....*
gi 66932916 196 PEIMLNsKGYTKSIDIWSVGCILAEMLSNRPIFPG 230
Cdd:cd05609 184 PEVILR-QGYGKPVDWWAMGIILYEFLVGCVPFFG 217
STKc_PDIK1L cd13977
Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs ...
24-301 4.20e-15

Catalytic domain of the Serine/Threonine kinase, PDLIM1 interacting kinase 1 like; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PDIK1L is also called STK35 or CLIK-1. It is predominantly a nuclear protein which is capable of autophosphorylation. Through its interaction with the PDZ-LIM protein CLP-36, it is localized to actin stress fibers. The PDIK1L subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270879 [Multi-domain]  Cd Length: 322  Bit Score: 75.29  E-value: 4.20e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpfehqtyCQR------TLREIKIL--LRFRHENIIGINDII--RAP 93
Cdd:cd13977   1 KYSLIREVGRGSYGVVYEAVVRRTGARVAVKKIR-------CNApenvelALREFWALssIQRQHPNVIQLEECVlqRDG 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  94 TIEQMKDVYIVQD----LMET--------------------------DLYKLLKTQHLSNDHICYFLYQILRGLKYIHSA 143
Cdd:cd13977  74 LAQRMSHGSSKSDlyllLVETslkgercfdprsacylwfvmefcdggDMNEYLLSRRPDRQTNTSFMLQLSSALAFLHRN 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 144 NVLHRDLKPSNLLLNTTCD---LKICDFGLARV--------ADPDHDHTGFLTEYVATRWYRAPEIMlnSKGYTKSIDIW 212
Cdd:cd13977 154 QIVHRDLKPDNILISHKRGepiLKVADFGLSKVcsgsglnpEEPANVNKHFLSSACGSDFYMAPEVW--EGHYTAKADIF 231
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 213 SVGCILAEMLSnRPIFPGKH--------YLDQLNHILgilgsPSQEDLnciinLKARNYLLSLPHKNKVPWNRlfpnads 284
Cdd:cd13977 232 ALGIIIWAMVE-RITFRDGEtkkellgtYIQQGKEIV-----PLGEAL-----LENPKLELQIPLKKKKSMND------- 293
                       330
                ....*....|....*..
gi 66932916 285 KALDLLDKMLTFNPHKR 301
Cdd:cd13977 294 DMKQLLRDMLAANPQER 310
STKc_SnRK2 cd14662
Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein ...
24-222 4.37e-15

Catalytic domain of the Serine/Threonine Kinases, Sucrose nonfermenting 1-related protein kinase subfamily 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The SnRKs form three different subfamilies designated SnRK1-3. SnRK2 is represented in this cd. SnRK2s are involved in plant response to abiotic stresses and abscisic acid (ABA)-dependent plant development. The SnRK2s subfamily is in turn classed into three subgroups, all 3 of which are represented in this CD. Group 1 comprises kinases not activated by ABA, group 2 - kinases not activated or activated very weakly by ABA (depending on plant species), and group 3 - kinases strongly activated by ABA. The SnRKs belong to a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271132 [Multi-domain]  Cd Length: 257  Bit Score: 74.04  E-value: 4.37e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTieqmkDVYI 103
Cdd:cd14662   1 RYELVKDIGSGNFGVARLMRNKETKELVAVKYIE--RGLKIDENVQREIINHRSLRHPNIIRFKEVVLTPT-----HLAI 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VqdlME----TDLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL--NTTCDLKICDFGLARVA-- 174
Cdd:cd14662  74 V---MEyaagGELFeRICNAGRFSEDEARYFFQQLISGVSYCHSMQICHRDLKLENTLLdgSPAPRLKICDFGYSKSSvl 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 175 --DPdhdhtgflTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 222
Cdd:cd14662 151 hsQP--------KSTVGTPAYIAPEVLSRKEYDGKVADVWSCGVTLYVML 192
STKc_MLK1 cd14145
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the ...
31-230 4.60e-15

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK1 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K9. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. Little is known about the specific function of MLK1. It is capable of activating the c-Jun N-terminal kinase pathway. Mice lacking both MLK1 and MLK2 are viable, fertile, and have normal life spans. There could be redundancy in the function of MLKs. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271047 [Multi-domain]  Cd Length: 270  Bit Score: 74.31  E-value: 4.60e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLR-EIKILLRFRHENIIGINDI-IRAPTIeqmkdVYIVQDLM 108
Cdd:cd14145  14 IGIGGFGKVYRAIWIGDEVAVKAARHDPDEDISQTIENVRqEAKLFAMLKHPNIIALRGVcLKEPNL-----CLVMEFAR 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHS---ANVLHRDLKPSNLLLNTTCD--------LKICDFGLARvadpD 177
Cdd:cd14145  89 GGPLNRVLSGKRIPPDILVNWAVQIARGMNYLHCeaiVPVIHRDLKSSNILILEKVEngdlsnkiLKITDFGLAR----E 164
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 178 HDHTGFLTEYVATRWYrAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPG 230
Cdd:cd14145 165 WHRTTKMSAAGTYAWM-APEVIRSSM-FSKGSDVWSYGVLLWELLTGEVPFRG 215
PTKc_VEGFR cd05054
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
31-223 5.42e-15

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The VEGFR subfamily consists of VEGFR1 (Flt1), VEGFR2 (Flk1), VEGFR3 (Flt4), and similar proteins. VEGFR subfamily members are receptor PTKss (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. In VEGFR3, the fifth Ig-like domain is replaced by a disulfide bridge. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. There are five VEGF ligands in mammals, which bind, in an overlapping pattern to the three VEGFRs, which can form homo or heterodimers. VEGFRs regulate the cardiovascular system. They are critical for vascular development during embryogenesis and blood vessel formation in adults. They induce cellular functions common to other growth factor receptors such as cell migration, survival, and proliferation. The VEGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270647 [Multi-domain]  Cd Length: 298  Bit Score: 74.45  E-value: 5.42e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSA----YDNVNKVR-VAIKKI----SPFEHQTYcqrtLREIKILLRFRHE----NIIGINDIIRAP---- 93
Cdd:cd05054  15 LGRGAFGKVIQAsafgIDKSATCRtVAVKMLkegaTASEHKAL----MTELKILIHIGHHlnvvNLLGACTKPGGPlmvi 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  94 --------------------TIEQMKDVYIVQDlmETDLYKLLKTQHLSNDHICYFlYQILRGLKYIHSANVLHRDLKPS 153
Cdd:cd05054  91 vefckfgnlsnylrskreefVPYRDKGARDVEE--EEDDDELYKEPLTLEDLICYS-FQVARGMEFLASRKCIHRDLAAR 167
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916 154 NLLLNTTCDLKICDFGLAR--VADPDHDHTGflTEYVATRWYrAPEIMLNsKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05054 168 NILLSENNVVKICDFGLARdiYKDPDYVRKG--DARLPLKWM-APESIFD-KVYTTQSDVWSFGVLLWEIFS 235
PTKc_PDGFR_alpha cd05105
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; ...
104-223 5.67e-15

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor alpha; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR alpha is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR alpha forms homodimers or heterodimers with PDGFR beta, depending on the nature of the PDGF ligand. PDGF-AA, PDGF-AB, and PDGF-CC induce PDGFR alpha homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR alpha signaling is important in the formation of lung alveoli, intestinal villi, mesenchymal dermis, and hair follicles, as well as in the development of oligodendrocytes, retinal astrocytes, neural crest cells, and testicular cells. Aberrant PDGFR alpha expression is associated with some human cancers. Mutations in PDGFR alpha have been found within a subset of gastrointestinal stromal tumors (GISTs). An active fusion protein FIP1L1-PDGFR alpha, derived from interstitial deletion, is associated with idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia. The PDGFR alpha subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173653 [Multi-domain]  Cd Length: 400  Bit Score: 75.45  E-value: 5.67e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLKTQHLSNdhicyFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGF 183
Cdd:cd05105 222 VKNLLSDDGSEGLTTLDLLS-----FTYQVARGMEFLASKNCVHRDLAARNVLLAQGKIVKICDFGLARDIMHDSNYVSK 296
                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYVATRWYrAPEIMLNSKgYTKSIDIWSVGCILAEMLS 223
Cdd:cd05105 297 GSTFLPVKWM-APESIFDNL-YTTLSDVWSYGILLWEIFS 334
STKc_MLCK3 cd14192
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze ...
71-313 5.77e-15

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK3 (or MYLK3) phosphorylates myosin regulatory light chain 2 and controls the contraction of cardiac muscles. It is expressed specifically in both the atrium and ventricle of the heart and its expression is regulated by the cardiac protein Nkx2-5. MLCK3 plays an important role in cardiogenesis by regulating the assembly of cardiac sarcomeres, the repeating contractile unit of striated muscle. MLCK3 contains a single kinase domain near the C-terminus and a unique N-terminal half, and unlike MLCK1/2, it does not appear to be regulated by Ca2+/calmodulin. The MLCK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271094 [Multi-domain]  Cd Length: 261  Bit Score: 73.84  E-value: 5.77e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  71 EIKILLRFRHENIIGINDiirapTIEQMKDVYIVQDLMET-DLYKLL--KTQHLSNDHICYFLYQILRGLKYIHSANVLH 147
Cdd:cd14192  51 EINIMNQLNHVNLIQLYD-----AFESKTNLTLIMEYVDGgELFDRItdESYQLTELDAILFTRQICEGVHYLHQHYILH 125
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 148 RDLKPSNLL-LNTTCD-LKICDFGLARVADPDHDhtgfLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNR 225
Cdd:cd14192 126 LDLKPENILcVNSTGNqIKIIDFGLARRYKPREK----LKVNFGTPEFLAPEV-VNYDFVSFPTDMWSVGVITYMLLSGL 200
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 226 PIFpgkhyldqlnhilgiLGSPSQEDLNCIINLKarnyllslphknkvpWN---RLFPNADSKALDLLDKMLTFNPHKRI 302
Cdd:cd14192 201 SPF---------------LGETDAETMNNIVNCK---------------WDfdaEAFENLSEEAKDFISRLLVKEKSCRM 250
                       250
                ....*....|.
gi 66932916 303 EVEQALAHPYL 313
Cdd:cd14192 251 SATQCLKHEWL 261
PKc_TOPK cd14001
Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer ...
52-223 6.12e-15

Catalytic domain of the Dual-specificity protein kinase, Lymphokine-activated killer T-cell-originated protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TOPK, also called PDZ-binding kinase (PBK), is activated at the early stage of mitosis and plays a critical role in cytokinesis. It partly functions as a mitogen-activated protein kinase (MAPK) kinase and is capable of phosphorylating p38, JNK1, and ERK2. TOPK also plays a role in DNA damage sensing and repair through its phosphorylation of histone H2AX. It contributes to cancer development and progression by downregulating the function of tumor suppressor p53 and reducing cell-cycle regulatory proteins. TOPK is found highly expressed in breast and skin cancer cells. The TOPK subfamily is part of a larger superfamily that includes the catalytic domains of other protein kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270903 [Multi-domain]  Cd Length: 292  Bit Score: 74.36  E-value: 6.12e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  52 AIKKISPF----EHQTYCQRTLREIKILLRFRHENIIGIndiiRAPTIEQMKDVYIVQDLMETDLYKLLK------TQHL 121
Cdd:cd14001  32 AVKKINSKcdkgQRSLYQERLKEEAKILKSLNHPNIVGF----RAFTKSEDGSLCLAMEYGGKSLNDLIEeryeagLGPF 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 122 SNDHICYFLYQILRGLKYIHS-ANVLHRDLKPSNLLLNTTCD-LKICDFGlarVADP-DHDHTGFL---TEYVATRWYRA 195
Cdd:cd14001 108 PAATILKVALSIARALEYLHNeKKILHGDIKSGNVLIKGDFEsVKLCDFG---VSLPlTENLEVDSdpkAQYVGTEPWKA 184
                       170       180
                ....*....|....*....|....*...
gi 66932916 196 PEIMLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd14001 185 KEALEEGGVITDKADIFAYGLVLWEMMT 212
STKc_Raf cd14062
Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) ...
31-237 6.94e-15

Catalytic domain of the Serine/Threonine Kinases, Raf (Rapidly Accelerated Fibrosarcoma) kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Raf kinases act as mitogen-activated protein kinase kinase kinases (MAP3Ks, MKKKs, MAPKKKs), which phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. Aberrant expression or activation of components in this pathway are associated with tumor initiation, progression, and metastasis. Raf proteins contain a Ras binding domain, a zinc finger cysteine-rich domain, and a catalytic kinase domain. Vertebrates have three Raf isoforms (A-, B-, and C-Raf) with different expression profiles, modes of regulation, and abilities to function in the ERK cascade, depending on cellular context and stimuli. They have essential and non-overlapping roles during embryo- and organogenesis. Knockout of each isoform results in a lethal phenotype or abnormality in most mouse strains. The Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270964 [Multi-domain]  Cd Length: 253  Bit Score: 73.58  E-value: 6.94e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNkvrVAIKKI---SPFEHQTycQRTLREIKILLRFRHENIIGINDIIRAPTIEqmkdvyIVQDL 107
Cdd:cd14062   1 IGSGSFGTVYKGRWHGD---VAVKKLnvtDPTPSQL--QAFKNEVAVLRKTRHVNILLFMGYMTKPQLA------IVTQW 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 ME-TDLYKLLKTQHLSND--HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARvadpdhdhtgfl 184
Cdd:cd14062  70 CEgSSLYKHLHVLETKFEmlQLIDIARQTAQGMDYLHAKNIIHRDLKSNNIFLHEDLTVKIGDFGLAT------------ 137
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 185 teyVATRW--------------YRAPEI--MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 237
Cdd:cd14062 138 ---VKTRWsgsqqfeqptgsilWMAPEVirMQDENPYSFQSDVYAFGIVLYELLTGQLPYSHINNRDQI 203
STKc_GRK1 cd05608
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs ...
31-228 7.24e-15

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK1 (also called rhodopsin kinase) belongs to the visual group of GRKs and is expressed in retinal cells. It phosphorylates rhodopsin in rod cells, which leads to termination of the phototransduction cascade. Mutations in GRK1 are associated to a recessively inherited form of stationary nightblindness called Oguchi disease. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270759 [Multi-domain]  Cd Length: 288  Bit Score: 74.15  E-value: 7.24e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISP--FEHQTYCQRTLREIKILLRFRHENIIGIndiirAPTIEQMKDVYIVQDLM 108
Cdd:cd05608   9 LGKGGFGEVSACQMRATGKLYACKKLNKkrLKKRKGYEGAMVEKRILAKVHSRFIVSL-----AYAFQTKTDLCLVMTIM 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DL-YKLLKTQH----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA-RVADPDHDHT 181
Cdd:cd05608  84 NGgDLrYHIYNVDEenpgFQEPRACFYTAQIISGLEHLHQRRIIYRDLKPENVLLDDDGNVRISDLGLAvELKDGQTKTK 163
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 182 GflteYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd05608 164 G----YAGTPGFMAPELLLGEE-YDYSVDYFTLGVTLYEMIAARGPF 205
PTKc_EGFR_like cd05057
Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs ...
31-223 7.42e-15

Catalytic domain of Epidermal Growth Factor Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER, ErbB) subfamily members include EGFR (HER1, ErbB1), HER2 (ErbB2), HER3 (ErbB3), HER4 (ErbB4), and similar proteins. They are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, resulting in the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Collectively, they can recognize a variety of ligands including EGF, TGFalpha, and neuregulins, among others. All four subfamily members can form homo- or heterodimers. HER3 contains an impaired kinase domain and depends on its heterodimerization partner for activation. EGFR subfamily members are involved in signaling pathways leading to a broad range of cellular responses including cell proliferation, differentiation, migration, growth inhibition, and apoptosis. Gain of function alterations, through their overexpression, deletions, or point mutations in their kinase domains, have been implicated in various cancers. These receptors are targets of many small molecule inhibitors and monoclonal antibodies used in cancer therapy. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270648 [Multi-domain]  Cd Length: 279  Bit Score: 73.99  E-value: 7.42e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAY-----DNVnKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEqmkdvyIVQ 105
Cdd:cd05057  15 LGSGAFGTVYKGVwipegEKV-KIPVAIKVLREETGPKANEEILDEAYVMASVDHPHLVRLLGICLSSQVQ------LIT 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMEtdLYKLLK--TQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
Cdd:cd05057  88 QLMP--LGCLLDyvRNHrdnIGSQLLLNWCVQIAKGMSYLEEKRLVHRDLAARNVLVKTPNHVKITDFGLAKLLDVDEKE 165
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 66932916 181 TGFLTEYVATRWYrAPEIMLNSKgYTKSIDIWSVGCILAEMLS 223
Cdd:cd05057 166 YHAEGGKVPIKWM-ALESIQYRI-YTHKSDVWSYGVTVWELMT 206
PKc_MKK5 cd06619
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase ...
31-325 8.78e-15

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-activated protein Kinase Kinase 5; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MKK5 (also called MEK5) is a dual-specificity PK that phosphorylates its downstream target, extracellular signal-regulated kinase 5 (ERK5), on specific threonine and tyrosine residues. MKK5 is activated by MEKK2 and MEKK3 in response to mitogenic and stress stimuli. The ERK5 cascade promotes cell proliferation, differentiation, neuronal survival, and neuroprotection. This cascade plays an essential role in heart development. Mice deficient in either ERK5 or MKK5 die around embryonic day 10 due to cardiovascular defects including underdevelopment of the myocardium. In addition, MKK5 is associated with metastasis and unfavorable prognosis in prostate cancer. The MKK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132950 [Multi-domain]  Cd Length: 279  Bit Score: 73.76  E-value: 8.78e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIsPFEHQTYCQRT-LREIKILLRFRHENIIGIndiIRAPTIEQMkdVYIVQDLME 109
Cdd:cd06619   9 LGHGNGGTVYKAYHLLTRRILAVKVI-PLDITVELQKQiMSELEILYKCDSPYIIGF---YGAFFVENR--ISICTEFMD 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 ---TDLYKLLKTQHLSNDHICyflyqILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARvadpdHDHTGFLTE 186
Cdd:cd06619  83 ggsLDVYRKIPEHVLGRIAVA-----VVKGLTYLWSLKILHRDVKPSNMLVNTRGQVKLCDFGVST-----QLVNSIAKT 152
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 187 YVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRpiFPgkhYLD-QLNHilGILgSPSQEdLNCIINlkarnyll 265
Cdd:cd06619 153 YVGTNAYMAPERISGEQ-YGIHSDVWSLGISFMELALGR--FP---YPQiQKNQ--GSL-MPLQL-LQCIVD-------- 214
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 266 slPHKNKVPWNRLFPnadsKALDLLDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPIA 325
Cdd:cd06619 215 --EDPPVLPVGQFSE----KFVHFITQCMRKQPKERPAPENLMDHPFIVQYNDGNAEVVS 268
STKc_TLK2 cd14041
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2; STKs catalyze the ...
24-313 1.03e-14

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. They phosphorylate and regulate Anti-silencing function 1 protein (Asf1), a histone H3/H4 chaperone that helps facilitate the assembly of chromatin following DNA replication during S phase. TLKs also phosphorylate the H3 histone tail and are essential in transcription. Vertebrates contain two subfamily members, TLK1 and TLK2. The TLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270943 [Multi-domain]  Cd Length: 309  Bit Score: 73.94  E-value: 1.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIK------KISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTiEQ 97
Cdd:cd14041   7 RYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKihqlnkNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDT-DS 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  98 MKDVYIVQDLMETDLYkLLKTQHLSNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLL--NTTC-DLKICDFGLAR 172
Cdd:cd14041  86 FCTVLEYCEGNDLDFY-LKQHKLMSEKEARSIIMQIVNALKYLNEIKppIIHYDLKPGNILLvnGTACgEIKITDFGLSK 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 VADPDH----DHTGFLTEYVATRWYRAPEIMLNSKGYTK---SIDIWSVGCILAEMLSNRPIFPGKHyldqlnhilgilg 245
Cdd:cd14041 165 IMDDDSynsvDGMELTSQGAGTYWYLPPECFVVGKEPPKisnKVDVWSVGVIFYQCLYGRKPFGHNQ------------- 231
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 246 spSQEDL---NCIinLKARNylLSLPHKnkvpwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14041 232 --SQQDIlqeNTI--LKATE--VQFPPK---------PVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYL 287
STKc_LATS cd05598
Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor; STKs catalyze the ...
25-228 1.21e-14

Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS was originally identified in Drosophila using a screen for genes whose inactivation led to overproliferation of cells. In tetrapods, there are two LATS isoforms, LATS1 and LATS2. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. LATS functions as a tumor suppressor and is implicated in cell cycle regulation. The LATS subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270749 [Multi-domain]  Cd Length: 333  Bit Score: 73.89  E-value: 1.21e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNkvrvaikkispfeHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQM-KDVYI 103
Cdd:cd05598   3 FEKIKTIGVGAFGEVSLVRKKDT-------------NALYAMKTLRKKDVLKRNQVAHVKAERDILAEADNEWVvKLYYS 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQD------LME----TDLYKLLKTQHLSNDHI-CYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAr 172
Cdd:cd05598  70 FQDkenlyfVMDyipgGDLMSLLIKKGIFEEDLaRFYIAELVCAIESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLC- 148
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 173 vadpdhdhTGFL----TEY------VATRWYRAPEIMLNSkGYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd05598 149 --------TGFRwthdSKYylahslVGTPNYIAPEVLLRT-GYTQLCDWWSVGVILYEMLVGQPPF 205
STKc_Kalirin_C cd14115
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
31-312 1.21e-14

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Kalirin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Kalirin, also called Duo or Duet, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. As a GEF, it activates Rac1, RhoA, and RhoG. It is highly expressed in neurons and is required for spine formation. The kalirin gene produces at least 10 isoforms from alternative promoter use and splicing. Of the major isoforms (Kalirin-7, -9, and -12), only kalirin-12 contains the C-terminal kinase domain. Kalirin-12 is highly expressed during embryonic development and it plays an important role in axon outgrowth. The Kalirin subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271017 [Multi-domain]  Cd Length: 248  Bit Score: 72.69  E-value: 1.21e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTycQRTLREIKILLRFRHENIIGINDIIRAPT-----IEQMKDVYIVQ 105
Cdd:cd14115   1 IGRGRFSIVKKCLHKATRKDVAVKFVSKKMKKK--EQAAHEAALLQHLQHPQYITLHDTYESPTsyilvLELMDDGRLLD 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETDlykllktqHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFGLArVADPDHDHTG 182
Cdd:cd14115  79 YLMNHD--------ELMEEKVAFYIRDIMEALQYLHNCRVAHLDIKPENLLIDLRIPvprVKLIDLEDA-VQISGHRHVH 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 183 FLteyVATRWYRAPEIMlnsKGYTKSI--DIWSVGCILAEMLSNrpIFPgkhYLDQlnhilgilgSPSQEDLN-CIINlk 259
Cdd:cd14115 150 HL---LGNPEFAAPEVI---QGTPVSLatDIWSIGVLTYVMLSG--VSP---FLDE---------SKEETCINvCRVD-- 207
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 260 arnylLSLPHKnkvpwnrLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPY 312
Cdd:cd14115 208 -----FSFPDE-------YFGDVSQAARDFINVILQEDPRRRPTAATCLQHPW 248
PTKc_Jak3_rpt2 cd05081
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the ...
28-234 1.35e-14

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Janus kinase 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Jak3 is expressed only in hematopoietic cells. It binds the shared receptor subunit common gamma chain and thus, is essential in the signaling of cytokines that use it such as IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Jak3 is important in lymphoid development and myeloid cell differentiation. Inactivating mutations in Jak3 have been reported in humans with severe combined immunodeficiency (SCID). Jak3 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal catalytic tyr kinase domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270665 [Multi-domain]  Cd Length: 283  Bit Score: 73.00  E-value: 1.35e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGMV--CSaYD----NVNKVrVAIKKI--SPFEHQTYCQRtlrEIKILLRFRHENIIGINDIIRAPTIEQMK 99
Cdd:cd05081   9 ISQLGKGNFGSVelCR-YDplgdNTGAL-VAVKQLqhSGPDQQRDFQR---EIQILKALHSDFIVKYRGVSYGPGRRSLR 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 dvYIVQDLMETDLYKLL-KTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPD 177
Cdd:cd05081  84 --LVMEYLPSGCLRDFLqRHRArLDASRLLLYSSQICKGMEYLGSRRCVHRDLAARNILVESEAHVKIADFGLAKLLPLD 161
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 178 HDHtgflteYVATR-------WYrAPEiMLNSKGYTKSIDIWSVGCILAEML--SNRPIFPGKHYL 234
Cdd:cd05081 162 KDY------YVVREpgqspifWY-APE-SLSDNIFSRQSDVWSFGVVLYELFtyCDKSCSPSAEFL 219
STKc_GRK7 cd05607
Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; ...
25-228 1.55e-14

Catalytic domain of the Protein Serine/Threonine Kinase, G protein-coupled Receptor Kinase 7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK7 (also called iodopsin kinase) belongs to the visual group of GRKs. It is primarily found in the retina and plays a role in the regulation of opsin light receptors. GRK7 is located in retinal cone outer segments and plays an important role in regulating photoresponse of the cones. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors, which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK7 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270758 [Multi-domain]  Cd Length: 286  Bit Score: 73.01  E-value: 1.55e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYC--QRTLREIKILLRFRHENIIGIndiirAPTIEQMKDVY 102
Cdd:cd05607   4 FYEFRVLGKGGFGEVCAVQVKNTGQMYACKKLDKKRLKKKSgeKMALLEKEILEKVNSPFIVSL-----AYAFETKTHLC 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKL----LKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLArVADPDH 178
Cdd:cd05607  79 LVMSLMNGGDLKYhiynVGERGIEMERVIFYSAQITCGILHLHSLKIVYRDMKPENVLLDDNGNCRLSDLGLA-VEVKEG 157
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 179 DHTgflTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd05607 158 KPI---TQRAGTNGYMAPEI-LKEESYSYPVDWFAMGCSIYEMVAGRTPF 203
STKc_MAP4K5 cd06646
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
25-313 1.76e-14

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K5, also called germinal center kinase-related enzyme (GCKR), has been shown to activate the MAPK c-Jun N-terminal kinase (JNK). MAP4K5 also facilitates Wnt signaling in B cells, and may therefore be implicated in the control of cell fate, proliferation, and polarity. MAP4Ks are involved in some MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270813 [Multi-domain]  Cd Length: 268  Bit Score: 72.75  E-value: 1.76e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAyDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDiirapTIEQMKDVYIV 104
Cdd:cd06646  11 YELIQRVGSGTYGDVYKA-RNLHTGELAAVKIIKLEPGDDFSLIQQEIFMVKECKHCNIVAYFG-----SYLSREKLWIC 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLME----TDLYKLlkTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGL-ARVADPDHD 179
Cdd:cd06646  85 MEYCGggslQDIYHV--TGPLSELQIAYVCRETLQGLAYLHSKGKMHRDIKGANILLTDNGDVKLADFGVaAKITATIAK 162
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 HTGFlteyVATRWYRAPEIMLNSK--GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLnhilgilgspsqedlnciiN 257
Cdd:cd06646 163 RKSF----IGTPYWMAPEVAAVEKngGYNQLCDIWAVGITAIELAELQPPMFDLHPMRAL-------------------F 219
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 258 LKARNYLLSLPHKNKVPWNRLFPNadskaldLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06646 220 LMSKSNFQPPKLKDKTKWSSTFHN-------FVKISLTKNPKKRPTAERLLTHLFV 268
PTKc_Chk cd05083
Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the ...
31-223 1.92e-14

Catalytic domain of the Protein Tyrosine Kinase, Csk homologous kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Chk is also referred to as megakaryocyte-associated tyrosine kinase (Matk). Chk inhibits Src kinases using a noncatalytic mechanism by simply binding to them. As a negative regulator of Src kinases, Chk may play important roles in cell proliferation, survival, and differentiation, and consequently, in cancer development and progression. Chk is expressed in brain and hematopoietic cells. Like Csk, it is a cytoplasmic (or nonreceptor) tyr kinase containing the Src homology domains, SH3 and SH2, N-terminal to the catalytic tyr kinase domain. To inhibit Src kinases that are anchored to the plasma membrane, Chk is translocated to the membrane via binding to specific transmembrane proteins, G-proteins, or adaptor proteins near the membrane. Studies in mice reveal that Chk is not functionally redundant with Csk and that it plays an important role as a regulator of immune responses. Chk also plays a role in neural differentiation in a manner independent of Src by enhancing Mapk activation via Ras-mediated signaling. The Chk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270666 [Multi-domain]  Cd Length: 254  Bit Score: 72.21  E-value: 1.92e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAydNVNKVRVAIKKIspfEHQTYCQRTLREIKILLRFRHENIIGINDIIRAptieqmKDVYIVQDLM-E 109
Cdd:cd05083  14 IGEGEFGAVLQG--EYMGQKVAVKNI---KCDVTAQAFLEETAVMTKLQHKNLVRLLGVILH------NGLYIVMELMsK 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKTQH---LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDhtgflTE 186
Cdd:cd05083  83 GNLVNFLRSRGralVPVIQLLQFSLDVAEGMEYLESKKLVHRDLAARNILVSEDGVAKISDFGLAKVGSMGVD-----NS 157
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 66932916 187 YVATRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05083 158 RLPVKW-TAPEALKNKKFSSKS-DVWSYGVLLWEVFS 192
STKc_cPKC_beta cd05616
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs ...
96-231 2.12e-14

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PKC beta isoforms (I and II), generated by alternative splicing of a single gene, are preferentially activated by hyperglycemia-induced DAG (1,2-diacylglycerol) in retinal tissues. This is implicated in diabetic microangiopathy such as ischemia, neovascularization, and abnormal vasodilator function. PKC-beta also plays an important role in VEGF signaling. In addition, glucose regulates proliferation in retinal endothelial cells via PKC-betaI. PKC-beta is also being explored as a therapeutic target in cancer. It contributes to tumor formation and is involved in the tumor host mechanisms of inflammation and angiogenesis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG, and in most cases, phosphatidylserine (PS) for activation. The cPKC-beta subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270767 [Multi-domain]  Cd Length: 323  Bit Score: 73.11  E-value: 2.12e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  96 EQMKDVYIVQDLMETD--LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV 173
Cdd:cd05616  71 QTMDRLYFVMEYVNGGdlMYHIQQVGRFKEPHAVFYAAEIAIGLFFLQSKGIIYRDLKLDNVMLDSEGHIKIADFGMCKE 150
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 174 ADPDhdhtGFLTE-YVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 231
Cdd:cd05616 151 NIWD----GVTTKtFCGTPDYIAPEI-IAYQPYGKSVDWWAFGVLLYEMLAGQAPFEGE 204
STKc_PKB_beta cd05595
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); ...
112-232 2.31e-14

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B beta (also called Akt2); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-beta is the predominant PKB isoform expressed in insulin-responsive tissues. It plays a critical role in the regulation of glucose homeostasis. It is also implicated in muscle cell differentiation. Mice deficient in PKB-beta display normal growth weights but exhibit severe insulin resistance and diabetes, accompanied by lipoatrophy and B-cell failure. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain.The PKB-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173686 [Multi-domain]  Cd Length: 323  Bit Score: 73.12  E-value: 2.31e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 112 LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHdhtGFLTEYVATR 191
Cdd:cd05595  83 FFHLSRERVFTEDRARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGITDG---ATMKTFCGTP 159
                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 66932916 192 WYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKH 232
Cdd:cd05595 160 EYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRlPFYNQDH 200
STKc_LIMK1 cd14221
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the ...
31-222 2.39e-14

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK1 activation is induced by bone morphogenic protein, vascular endothelial growth factor, and thrombin. It plays roles in microtubule disassembly and cell cycle progression, and is critical in the regulation of neurite outgrowth. LIMK1 knockout mice show abnormalities in dendritic spine morphology and synaptic function. LIMK1 is one of the genes deleted in patients with Williams Syndrome, which is characterized by distinct craniofacial features, cardiovascular problems, as well as behavioral and neurological abnormalities. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271123 [Multi-domain]  Cd Length: 267  Bit Score: 72.30  E-value: 2.39e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTycQRT-LREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLME 109
Cdd:cd14221   1 LGKGCFGQAIKVTHRETGEVMVMKELIRFDEET--QRTfLKEVKVMRCLEHPNVLKFIGVLYKDKRLNFITEYIKGGTLR 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 tDLYKLLKTQHLSNDHICyFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTE--- 186
Cdd:cd14221  79 -GIIKSMDSHYPWSQRVS-FAKDIASGMAYLHSMNIIHRDLNSHNCLVRENKSVVVADFGLARLMVDEKTQPEGLRSlkk 156
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 66932916 187 --------YVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEML 222
Cdd:cd14221 157 pdrkkrytVVGNPYWMAPE-MINGRSYDEKVDVFSFGIVLCEII 199
STKc_MSK2_N cd05614
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
102-360 2.47e-14

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK2 and MSK1 play nonredundant roles in activating histone H3 kinases, which play pivotal roles in compaction of the chromatin fiber. MSK2 is the required H3 kinase in response to stress stimuli and activation of the p38 MAPK pathway. MSK2 also plays a role in the pathogenesis of psoriasis. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family, similar to 90 kDa ribosomal protein S6 kinases (RSKs). MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270765 [Multi-domain]  Cd Length: 332  Bit Score: 73.03  E-value: 2.47e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMETDLYKllkTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARvadpdhdht 181
Cdd:cd05614  86 YVSGGELFTHLYQ---RDHFSEDEVRFYSGEIILALEHLHKLGIVYRDIKLENILLDSEGHVVLTDFGLSK--------- 153
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 GFLTE-------YVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspSQEDLNC 254
Cdd:cd05614 154 EFLTEekertysFCGTIEYMAPEIIRGKSGHGKAVDWWSLGILMFELLTGASPFTLEGEKNTQSEV-------SRRILKC 226
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 255 iinlkarnyllslphknkvpwNRLFPNADS-KALDLLDKMLTFNPHKRIEVEQALAhpyleqyydpsdEPIAEAPFKFDM 333
Cdd:cd05614 227 ---------------------DPPFPSFIGpVARDLLQKLLCKDPKKRLGAGPQGA------------QEIKEHPFFKGL 273
                       250       260
                ....*....|....*....|....*..
gi 66932916 334 ELDDLPKEKLKelifeetARFQPGYRS 360
Cdd:cd05614 274 DWEALALRKVN-------PPFRPSIRS 293
PK_SCY1_like cd14011
Pseudokinase domain of Scy1-like proteins; The pseudokinase domain shows similarity to protein ...
70-314 2.72e-14

Pseudokinase domain of Scy1-like proteins; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. This subfamily is composed of the catalytically inactive kinases with similarity to yeast Scy1. It includes four mammalian proteins called SCY1-like protein 1 (SCYL1), SCYL2, SCYL3, as well as Testis-EXpressed protein 14 (TEX14). SCYL1 binds to and co-localizes with the membrane trafficking coatomer I (COPI) complex, and regulates COPI-mediated vesicle trafficking. Null mutations in the SCYL1 gene are responsible for the pathology in mdf (muscle-deficient) mice which display progressive motor neuropathy. SCYL2, also called coated vesicle-associated kinase of 104 kDa (CVAK104), is involved in the trafficking of clathrin-coated vesicles. It also binds the HIV-1 accessory protein Vpu and acts as a regulatory factor that promotes the dephosphorylation of Vpu, facilitating the restriction of HIV-1 release. SCYL3, also called ezrin-binding protein PACE-1, may be involved in regulating cell adhesion and migration. TEX14 is required for spermatogenesis and male fertility. It localizes to kinetochores (KT) during mitosis and is a target of the mitotic kinase PLK1. It regulates the maturation of the outer KT and the KT-microtubule attachment. The SCY1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270913 [Multi-domain]  Cd Length: 287  Bit Score: 72.35  E-value: 2.72e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  70 REIKILLRFRHENIIgindIIRAPTIEQMKDVYIV---------QDLMETD----LYKLLKTQHLSNDHICYFLYQILRG 136
Cdd:cd14011  51 RGVKQLTRLRHPRIL----TVQHPLEESRESLAFAtepvfaslaNVLGERDnmpsPPPELQDYKLYDVEIKYGLLQISEA 126
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 137 LKYIH-SANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRW--------YRAPEIMLnSKGYTK 207
Cdd:cd14011 127 LSFLHnDVKLVHGNICPESVVINSNGEWKLAGFDFCISSEQATDQFPYFREYDPNLPplaqpnlnYLAPEYIL-SKTCDP 205
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 208 SIDIWSVGCILAEMLSNR-PIFPGKHYLDQLNHILGILGSpsqedlnciinlkarnylLSLPHKNKVPwnrlfpnadSKA 286
Cdd:cd14011 206 ASDMFSLGVLIYAIYNKGkPLFDCVNNLLSYKKNSNQLRQ------------------LSLSLLEKVP---------EEL 258
                       250       260
                ....*....|....*....|....*...
gi 66932916 287 LDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd14011 259 RDHVKTLLNVTPEVRPDAEQLSKIPFFD 286
STKc_TNIK cd06637
Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs ...
110-313 3.20e-14

Catalytic domain of the Serine/Threonine Kinase, Traf2- and Nck-Interacting Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TNIK is an effector of Rap2, a small GTP-binding protein from the Ras family. TNIK specifically activates the c-Jun N-terminal kinase (JNK) pathway and plays a role in regulating the actin cytoskeleton. The TNIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270807 [Multi-domain]  Cd Length: 296  Bit Score: 72.44  E-value: 3.20e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDhdhTGFLTEYVA 189
Cdd:cd06637  97 TDLIKNTKGNTLKEEWIAYICREILRGLSHLHQHKVIHRDIKGQNVLLTENAEVKLVDFGVSAQLDRT---VGRRNTFIG 173
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 190 TRWYRAPEIMLNSKG----YTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqedlnciinlkARNyll 265
Cdd:cd06637 174 TPYWMAPEVIACDENpdatYDFKSDLWSLGITAIEMAEGAPPLCDMHPMRALFLI-------------------PRN--- 231
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 66932916 266 SLPHKNKVPWNRLFPNadskaldLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd06637 232 PAPRLKSKKWSKKFQS-------FIESCLVKNHSQRPSTEQLMKHPFI 272
PTKc_Tec_Rlk cd05114
Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular ...
31-223 3.29e-14

Catalytic domain of the Protein Tyrosine Kinases, Tyrosine kinase expressed in hepatocellular carcinoma and Resting lymphocyte kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tec and Rlk (also named Txk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. Instead of PH, Rlk contains an N-terminal cysteine-rich region. In addition to PH, Tec also contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Tec kinases are expressed mainly by haematopoietic cells. Tec is more widely-expressed than other Tec-like subfamily kinases. It is found in endothelial cells, both B- and T-cells, and a variety of myeloid cells including mast cells, erythroid cells, platelets, macrophages and neutrophils. Rlk is expressed in T-cells and mast cell lines. Tec and Rlk are both key components of T-cell receptor (TCR) signaling. They are important in TCR-stimulated proliferation, IL-2 production and phopholipase C-gamma1 activation. The Tec/Rlk subfamily is part of a larger superfamily, that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270685 [Multi-domain]  Cd Length: 260  Bit Score: 71.82  E-value: 3.29e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVcsaydNVNKVR----VAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKDVYIVQD 106
Cdd:cd05114  12 LGSGLFGVV-----RLGKWRaqykVAIKAIR--EGAMSEEDFIEEAKVMMKLTHPKLVQLYGVC-----TQQKPIYIVTE 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LMETD-LYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGF 183
Cdd:cd05114  80 FMENGcLLNYLRQRrgKLSRDMLLSMCQDVCEGMEYLERNNFIHRDLAARNCLVNDTGVVKVSDFGMTRYVLDDQYTSSS 159
                       170       180       190       200
                ....*....|....*....|....*....|....*....|
gi 66932916 184 LTEYvATRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05114 160 GAKF-PVKW-SPPEVFNYSKFSSKS-DVWSFGVLMWEVFT 196
STKc_GRK5 cd05632
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs ...
31-231 4.04e-14

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 5; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK5 is widely expressed in many tissues. It associates with the membrane though an N-terminal PIP2 binding domain and also binds phospholipids via its C-terminus. GRK5 deficiency is associated with early Alzheimer's disease in humans and mouse models. GRK5 also plays a crucial role in the pathogenesis of sporadic Parkinson's disease. It participates in the regulation and desensitization of PDGFRbeta, a receptor tyrosine kinase involved in a variety of downstream cellular effects including cell growth, chemotaxis, apoptosis, and angiogenesis. GRK5 also regulates Toll-like receptor 4, which is involved in innate and adaptive immunity. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK5 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270780 [Multi-domain]  Cd Length: 313  Bit Score: 72.31  E-value: 4.04e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIspfEHQTYCQR-----TLREIKILLRFRHENIIGIndiirAPTIEQMKDVYIVQ 105
Cdd:cd05632  10 LGKGGFGEVCACQVRATGKMYACKRL---EKKRIKKRkgesmALNEKQILEKVNSQFVVNL-----AYAYETKDALCLVL 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETDLYKL----LKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLArVADPDHDht 181
Cdd:cd05632  82 TIMNGGDLKFhiynMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLA-VKIPEGE-- 158
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 182 gFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 231
Cdd:cd05632 159 -SIRGRVGTVGYMAPEV-LNNQRYTLSPDYWGLGCLIYEMIEGQSPFRGR 206
PTZ00267 PTZ00267
NIMA-related protein kinase; Provisional
129-314 4.71e-14

NIMA-related protein kinase; Provisional


Pssm-ID: 140293 [Multi-domain]  Cd Length: 478  Bit Score: 73.13  E-value: 4.71e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  129 FLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpDHDHTGFLTEYVATRWYRAPEIMlNSKGYTKS 208
Cdd:PTZ00267 174 LFYQIVLALDEVHSRKMMHRDLKSANIFLMPTGIIKLGDFGFSKQYS-DSVSLDVASSFCGTPYYLAPELW-ERKRYSKK 251
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  209 IDIWSVGCILAEMLS-NRPiFPGkhyldqlnhilgilgsPSQedlnciinlkaRNYLLSLPHKNKVPwnrlFPNADSKAL 287
Cdd:PTZ00267 252 ADMWSLGVILYELLTlHRP-FKG----------------PSQ-----------REIMQQVLYGKYDP----FPCPVSSGM 299
                        170       180
                 ....*....|....*....|....*...
gi 66932916  288 D-LLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:PTZ00267 300 KaLLDPLLSKNPALRPTTQQLLHTEFLK 327
STKc_MAP4K3 cd06645
Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase ...
31-315 4.84e-14

Catalytic domain of the Serine/Threonine Kinase, Mitogen-activated protein kinase kinase kinase kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAP4K3 plays a role in the nutrient-responsive pathway of mTOR (mammalian target of rapamycin) signaling. MAP4K3 is required in the activation of S6 kinase by amino acids and for the phosphorylation of the mTOR-regulated inhibitor of eukaryotic initiation factor 4E. mTOR regulates ribosome biogenesis and protein translation, and is frequently deregulated in cancer. MAP4Ks are involved in MAPK signaling pathways by activating a MAPK kinase kinase. Each MAPK cascade is activated either by a small GTP-binding protein or by an adaptor protein, which transmits the signal either directly to a MAP3K to start the triple kinase core cascade or indirectly through a mediator kinase, a MAP4K. Members of this subfamily contain an N-terminal catalytic domain and a C-terminal citron homology (CNH) regulatory domain. The MAP4K3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270812 [Multi-domain]  Cd Length: 272  Bit Score: 71.61  E-value: 4.84e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAyDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIG-INDIIRAPTI---------EQMKD 100
Cdd:cd06645  19 IGSGTYGDVYKA-RNVNTGELAAIKVIKLEPGEDFAVVQQEIIMMKDCKHSNIVAyFGSYLRRDKLwicmefcggGSLQD 97
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVqdlmetdlykllkTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGL-ARVADPDHD 179
Cdd:cd06645  98 IYHV-------------TGPLSESQIAYVSRETLQGLYYLHSKGKMHRDIKGANILLTDNGHVKLADFGVsAQITATIAK 164
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 HTGFlteyVATRWYRAPEIMLNSK--GYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLnhilgilgspsqedlnciiN 257
Cdd:cd06645 165 RKSF----IGTPYWMAPEVAAVERkgGYNQLCDIWAVGITAIELAELQPPMFDLHPMRAL-------------------F 221
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 258 LKARNYLLSLPHKNKVPWNRLFPNadskaldLLDKMLTFNPHKRIEVEQALAHPYLEQ 315
Cdd:cd06645 222 LMTKSNFQPPKLKDKMKWSNSFHH-------FVKMALTKNPKKRPTAEKLLQHPFVTQ 272
STK_BAK1_like cd14664
Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; ...
31-227 5.80e-14

Catalytic domain of the Serine/Threonine Kinase, BRI1 associated kinase 1 and related STKs; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily includes three leucine-rich repeat receptor-like kinases (LRR-RLKs): Arabidopsis thaliana BAK1 and CLAVATA1 (CLV1), and Physcomitrella patens CLL1B clavata1-like receptor S/T protein kinase. BAK1 functions in various signaling pathways. It plays a role in BR (brassinosteroid)-regulated plant development as a co-receptor of BRASSINOSTEROID (BR) INSENSITIVE 1 (BRI1), the receptor for BRs, and is required for full activation of BR signaling. It also modulates pathways involved in plant resistance to pathogen infection (pattern-triggered immunity, PTI) and herbivore attack (wound- or herbivore feeding-induced accumulation of jasmonic acid (JA) and JA-isoleucine. CLV1, directly binds small signaling peptides, CLAVATA3 (CLV3) and CLAVATA3/EMBRYO SURROUNDING REGI0N (CLE), to restrict stem cell proliferation: the CLV3-CLV1-WUS (WUSCHEL) module influences stem cell maintenance in the shoot apical meristem, and the CLE40 (CLAVATA3/EMBRYO SURROUNDING REGION40) -ACR4 (CRINKLY4) -CLV1- WOX5 (WUSCHEL-RELATED HOMEOBOX5) module at the root apical meristem. The STK_BAK1-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271134 [Multi-domain]  Cd Length: 270  Bit Score: 70.99  E-value: 5.80e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVcsaYDNV--NKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEqmkdvYIVQDLM 108
Cdd:cd14664   1 IGRGGAGTV---YKGVmpNGTLVAVKRLKGEGTQGGDHGFQAEIQTLGMIRHRNIVRLRGYCSNPTTN-----LLVYEYM 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLLKTQHLSNDHICY-----FLYQILRGLKYIH---SANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHD 179
Cdd:cd14664  73 PNgSLGELLHSRPESQPPLDWetrqrIALGSARGLAYLHhdcSPLIIHRDVKSNNILLDEEFEAHVADFGLAKLMDDKDS 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 180 HTgfLTEYVATRWYRAPEIMLNSKGYTKSiDIWSVGCILAEMLS-NRPI 227
Cdd:cd14664 153 HV--MSSVAGSYGYIAPEYAYTGKVSEKS-DVYSYGVVLLELITgKRPF 198
PTKc_DDR_like cd05097
Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the ...
31-223 6.27e-14

Catalytic domain of Discoidin Domain Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR-like proteins are members of the DDR subfamily, which are receptor PTKs (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDRs regulate cell adhesion, proliferation, and extracellular matrix remodeling. They have been linked to a variety of human cancers including breast, colon, ovarian, brain, and lung. There is no evidence showing that DDRs act as transforming oncogenes. They are more likely to play a role in the regulation of tumor growth and metastasis. The DDR-like subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133228 [Multi-domain]  Cd Length: 295  Bit Score: 71.55  E-value: 6.27e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMV--CSA-------------YDNvNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIG-----INDII 90
Cdd:cd05097  13 LGEGQFGEVhlCEAeglaeflgegapeFDG-QPVLVAVKMLRADVTKTARNDFLKEIKIMSRLKNPNIIRllgvcVSDDP 91
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  91 RAPTIEQMKDVYIVQDLMETDLYKLLKTQH----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKIC 166
Cdd:cd05097  92 LCMITEYMENGDLNQFLSQREIESTFTHANnipsVSIANLLYMAVQIASGMKYLASLNFVHRDLATRNCLVGNHYTIKIA 171
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 167 DFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSkgYTKSIDIWSVGCILAEMLS 223
Cdd:cd05097 172 DFGMSRNLYSGDYYRIQGRAVLPIRWMAWESILLGK--FTTASDVWAFGVTLWEMFT 226
STKc_BMPR2_AMHR2 cd14054
Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and ...
31-231 6.63e-14

Catalytic domain of the Serine/Threonine Kinases, Bone Morphogenetic Protein and Anti-Muellerian Hormone Type II Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR2 and AMHR2 belong to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors (GDFs), and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. BMPR2 and AMHR2 act primarily as a receptor for BMPs and AMH, respectively. BMPs induce bone and cartilage formation, as well as regulate tooth, kidney, skin, hair, haematopoietic, and neuronal development. Mutations in BMPR2A is associated with familial pulmonary arterial hypertension. AMH is mainly responsible for the regression of Mullerian ducts during male sex differentiation. It is expressed exclusively by somatic cells of the gonads. Mutations in either AMH or AMHR2 cause persistent Mullerian duct syndrome (PMDS), a rare form of male pseudohermaphroditism characterized by the presence of Mullerian derivatives (ovary and tubes) in otherwise normally masculine males. The BMPR2/AMHR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270956 [Multi-domain]  Cd Length: 300  Bit Score: 71.24  E-value: 6.63e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAydNVNKVRVAIKkISPFEHQTYCQrTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMET 110
Cdd:cd14054   3 IGQGRYGTVWKG--SLDERPVAVK-VFPARHRQNFQ-NEKDIYELPLMEHSNILRFIGADERPTADGRMEYLLVLEYAPK 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 -DLYKLLKTQHLSNDHICYFLYQILRGLKYIHS---------ANVLHRDLKPSNLLLNT--TCdlKICDFGLARV----- 173
Cdd:cd14054  79 gSLCSYLRENTLDWMSSCRMALSLTRGLAYLHTdlrrgdqykPAIAHRDLNSRNVLVKAdgSC--VICDFGLAMVlrgss 156
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 174 ---ADPDHDHTGFLTEyVATRWYRAPEI------MLNSKGYTKSIDIWSVGCILAEMLSNRP-IFPGK 231
Cdd:cd14054 157 lvrGRPGAAENASISE-VGTLRYMAPEVlegavnLRDCESALKQVDVYALGLVLWEIAMRCSdLYPGE 223
PTKc_PDGFR_beta cd05107
Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; ...
121-223 6.64e-14

Catalytic domain of the Protein Tyrosine Kinase, Platelet Derived Growth Factor Receptor beta; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. PDGFR beta is a receptor PTK (RTK) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding to its ligands, the PDGFs, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. PDGFR beta forms homodimers or heterodimers with PDGFR alpha, depending on the nature of the PDGF ligand. PDGF-BB and PDGF-DD induce PDGFR beta homodimerization. PDGFR signaling plays many roles in normal embryonic development and adult physiology. PDGFR beta signaling leads to a variety of cellular effects including the stimulation of cell growth and chemotaxis, as well as the inhibition of apoptosis and GAP junctional communication. It is critical in normal angiogenesis as it is involved in the recruitment of pericytes and smooth muscle cells essential for vessel stability. Aberrant PDGFR beta expression is associated with some human cancers. The continuously-active fusion proteins of PDGFR beta with COL1A1 and TEL are associated with dermatofibrosarcoma protuberans (DFSP) and a subset of chronic myelomonocytic leukemia (CMML), respectively. The PDGFR beta subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133238 [Multi-domain]  Cd Length: 401  Bit Score: 72.35  E-value: 6.64e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 121 LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYrAPEIML 200
Cdd:cd05107 236 LSYMDLVGFSYQVANGMEFLASKNCVHRDLAARNVLICEGKLVKICDFGLARDIMRDSNYISKGSTFLPLKWM-APESIF 314
                        90       100
                ....*....|....*....|...
gi 66932916 201 NSKgYTKSIDIWSVGCILAEMLS 223
Cdd:cd05107 315 NNL-YTTLSDVWSFGILLWEIFT 336
PTKc_VEGFR1 cd14207
Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; ...
111-223 6.91e-14

Catalytic domain of the Protein Tyrosine Kinases, Vascular Endothelial Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. VEGFR1 (or Flt1) binds VEGFA, VEGFB, and placenta growth factor (PLGF). It regulates monocyte and macrophage migration, vascular permeability, haematopoiesis, and the recruitment of haematopietic progenitor cells from the bone marrow. VEGFR1 is a member of the VEGFR subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with seven immunoglobulin (Ig)-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of VEGFRs to their ligands, the VEGFs, leads to receptor dimerization, activation, and intracellular signaling. The VEGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271109 [Multi-domain]  Cd Length: 340  Bit Score: 71.96  E-value: 6.91e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 DLYKLLKTQHlsnDHICYFlYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR--VADPDHDHTGflTEYV 188
Cdd:cd14207 171 DFYKRPLTME---DLISYS-FQVARGMEFLSSRKCIHRDLAARNILLSENNVVKICDFGLARdiYKNPDYVRKG--DARL 244
                        90       100       110
                ....*....|....*....|....*....|....*
gi 66932916 189 ATRWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd14207 245 PLKWM-APESIFDKIYSTKS-DVWSYGVLLWEIFS 277
STKc_beta_ARK cd05606
Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs ...
106-237 8.03e-14

Catalytic domain of the Serine/Threonine Kinase, beta-adrenergic receptor kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The beta-ARK group is composed of GRK2, GRK3, and similar proteins. GRK2 and GRK3 are both widely expressed in many tissues, although GRK2 is present at higher levels. They contain an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRK2 (also called beta-ARK or beta-ARK1) is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The beta-ARK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270757 [Multi-domain]  Cd Length: 279  Bit Score: 70.93  E-value: 8.03e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMET-DLYKLLkTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTG 182
Cdd:cd05606  78 DLMNGgDLHYHL-SQHgvFSEAEMRFYAAEVILGLEHMHNRFIVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPHAS 156
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 183 flteyVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF-----PGKHYLDQL 237
Cdd:cd05606 157 -----VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLYKLLKGHSPFrqhktKDKHEIDRM 211
STKc_MAPKAPK3 cd14172
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
93-313 9.13e-14

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 3 (MAPKAP3 or MK3) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK3 is a bonafide substrate for the MAPK p38. It is closely related to MK2 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. MK3 activity is only significant when MK2 is absent. The MK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271074 [Multi-domain]  Cd Length: 267  Bit Score: 70.40  E-value: 9.13e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  93 PTIEQMKDVY-----------IVQDLMET-DLYKLLKT---QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL 157
Cdd:cd14172  57 PHIVHILDVYenmhhgkrcllIIMECMEGgELFSRIQErgdQAFTEREASEIMRDIGTAIQYLHSMNIAHRDVKPENLLY 136
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 158 ---NTTCDLKICDFGLARvadpDHDHTGFLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhYL 234
Cdd:cd14172 137 tskEKDAVLKLTDFGFAK----ETTVQNALQTPCYTPYYVAPEV-LGPEKYDKSCDMWSLGVIMYILLCGFPPF----YS 207
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 235 DQLNHIlgilgSPSQEDlnciiNLKARNYLLSLPHKNKVpwnrlfpnaDSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14172 208 NTGQAI-----SPGMKR-----RIRMGQYGFPNPEWAEV---------SEEAKQLIRHLLKTDPTERMTITQFMNHPWI 267
STKc_GRK6 cd05630
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs ...
31-228 1.05e-13

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 6; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK6 is widely expressed in many tissues and is expressed as multiple splice variants with different domain architectures. It is post-translationally palmitoylated and localized in the membrane. GRK6 plays important roles in the regulation of dopamine, M3 muscarinic, opioid, and chemokine receptor signaling. It also plays maladaptive roles in addiction and Parkinson's disease. GRK6-deficient mice exhibit altered dopamine receptor regulation, decreased lymphocyte chemotaxis, and increased acute inflammation and neutrophil chemotaxis. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK6 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270779 [Multi-domain]  Cd Length: 285  Bit Score: 70.44  E-value: 1.05e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIspfEHQTYCQR-----TLREIKILLRFRHENIIGIndiirAPTIEQMKDVYIVQ 105
Cdd:cd05630   8 LGKGGFGEVCACQVRATGKMYACKKL---EKKRIKKRkgeamALNEKQILEKVNSRFVVSL-----AYAYETKDALCLVL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETDLYKL----LKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLArVADPDhDHT 181
Cdd:cd05630  80 TLMNGGDLKFhiyhMGQAGFPEARAVFYAAEICCGLEDLHRERIVYRDLKPENILLDDHGHIRISDLGLA-VHVPE-GQT 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 182 gfLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd05630 158 --IKGRVGTVGYMAPEVVKNER-YTFSPDWWALGCLLYEMIAGQSPF 201
PTKc_Tyk2_rpt2 cd05080
Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze ...
31-223 1.21e-13

Catalytic (repeat 2) domain of the Protein Tyrosine Kinase, Tyrosine kinase 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tyk2 is widely expressed in many tissues. It is involved in signaling via the cytokine receptors IFN-alphabeta, IL-6, IL-10, IL-12, IL-13, and IL-23. It mediates cell surface urokinase receptor (uPAR) signaling and plays a role in modulating vascular smooth muscle cell (VSMC) functional behavior in response to injury. Tyk2 is also important in dendritic cell function and T helper (Th)1 cell differentiation. A homozygous mutation of Tyk2 was found in a patient with hyper-IgE syndrome (HIES), a primary immunodeficiency characterized by recurrent skin abscesses, pneumonia, and elevated serum IgE. This suggests that Tyk2 may play important roles in multiple cytokine signaling involved in innate and adaptive immunity. Tyk2 is a member of the Janus kinase (Jak) subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs containing an N-terminal FERM domain, followed by a Src homology 2 (SH2) domain, a pseudokinase domain, and a C-terminal tyr kinase catalytic domain. Jaks are crucial for cytokine receptor signaling. They are activated by autophosphorylation upon cytokine-induced receptor aggregation, and subsequently trigger downstream signaling events such as the phosphorylation of signal transducers and activators of transcription (STATs). The Tyk2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270664 [Multi-domain]  Cd Length: 283  Bit Score: 70.31  E-value: 1.21e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVC-SAYDNVNK---VRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGIndiiRAPTIEQMKDvyIVQD 106
Cdd:cd05080  12 LGEGHFGKVSlYCYDPTNDgtgEMVAVKALKADCGPQHRSGWKQEIDILKTLYHENIVKY----KGCCSEQGGK--SLQL 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LME----TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHdhtg 182
Cdd:cd05080  86 IMEyvplGSLRDYLPKHSIGLAQLLLFAQQICEGMAYLHSQHYIHRDLAARNVLLDNDRLVKIGDFGLAKAVPEGH---- 161
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 183 fltEYVATR--------WYrAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05080 162 ---EYYRVRedgdspvfWY-APECLKEYKFYYAS-DVWSFGVTLYELLT 205
STKc_TLK1 cd14040
Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1; STKs catalyze the ...
24-313 1.24e-13

Catalytic domain of the Serine/Threonine kinase, Tousled-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A splice variant of TLK1, called TLK1B, is expressed in the presence of double strand breaks (DSBs). It lacks the N-terminal part of TLK1, but is expected to phosphorylate the same substrates. TLK1/1B interacts with Rad9, which is critical in DNA damage-activated checkpoint response, and plays a role in the repair of linearized DNA with incompatible ends. TLKs play important functions during the cell cycle and are implicated in chromatin remodeling, DNA replication and repair, and mitosis. The TLK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270942 [Multi-domain]  Cd Length: 299  Bit Score: 70.47  E-value: 1.24e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDnVNKVRVAIKKISPF-------EHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTie 96
Cdd:cd14040   7 RYLLLHLLGRGGFSEVYKAFD-LYEQRYAAVKIHQLnkswrdeKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDT-- 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 qmkDVY--IVQDLMETDLYKLLKTQHL-SNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLL--NTTC-DLKICDF 168
Cdd:cd14040  84 ---DTFctVLEYCEGNDLDFYLKQHKLmSEKEARSIVMQIVNALRYLNEIKppIIHYDLKPGNILLvdGTACgEIKITDF 160
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 169 GLARVADPDH---DHTGFLTEYVATRWYRAPEIMLNSKGYTK---SIDIWSVGCILAEMLSNRPIFPGKHyldqlnhilg 242
Cdd:cd14040 161 GLSKIMDDDSygvDGMDLTSQGAGTYWYLPPECFVVGKEPPKisnKVDVWSVGVIFFQCLYGRKPFGHNQ---------- 230
                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916 243 ilgspSQEDL---NCIinLKARNylLSLPHKnkvpwnrlfPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14040 231 -----SQQDIlqeNTI--LKATE--VQFPVK---------PVVSNEAKAFIRRCLAYRKEDRFDVHQLASDPYL 286
PTKc_FGFR cd05053
Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs ...
31-223 1.28e-13

Catalytic domain of the Protein Tyrosine Kinases, Fibroblast Growth Factor Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The FGFR subfamily consists of FGFR1, FGFR2, FGFR3, FGFR4, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, and to heparin/heparan sulfate (HS) results in the formation of a ternary complex, which leads to receptor dimerization and activation, and intracellular signaling. There are at least 23 FGFs and four types of FGFRs. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. FGF/FGFR signaling is important in the regulation of embryonic development, homeostasis, and regenerative processes. Depending on the cell type and stage, FGFR signaling produces diverse cellular responses including proliferation, growth arrest, differentiation, and apoptosis. Aberrant signaling leads to many human diseases such as skeletal, olfactory, and metabolic disorders, as well as cancer. The FGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase .


Pssm-ID: 270646 [Multi-domain]  Cd Length: 294  Bit Score: 70.52  E-value: 1.28e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSA----YDNV--NKVRVAIKKISPFEHQTYCQRTLREIKILLRF-RHENIIginDIIRAPTieQMKDVYI 103
Cdd:cd05053  20 LGEGAFGQVVKAeavgLDNKpnEVVTVAVKMLKDDATEKDLSDLVSEMEMMKMIgKHKNII---NLLGACT--QDGPLYV 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 V------------------QDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKI 165
Cdd:cd05053  95 VveyaskgnlreflrarrpPGEEASPDDPRVPEEQLTQKDLVSFAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKI 174
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916 166 CDFGLAR-VADPDH--DHT-GFLteyvATRWYrAPEiMLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05053 175 ADFGLARdIHHIDYyrKTTnGRL----PVKWM-APE-ALFDRVYTHQSDVWSFGVLLWEIFT 230
STKc_Trio_C cd14113
C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide ...
25-223 1.36e-13

C-terminal kinase domain of the Large Serine/Threonine Kinase and Rho Guanine Nucleotide Exchange Factor, Triple functional domain protein; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Triple functional domain protein (Trio), also called PTPRF-interacting protein, is a large multidomain protein containing a series of spectrin-like repeats, two each of RhoGEF and SH3 domains, an immunoglobulin-like (Ig) domain and a C-terminal kinase. Trio plays important roles in neuronal cell migration and axon guidance. It was originally identified as an interacting partner of the of the receptor-like tyrosine phosphatase (RPTP) LAR (leukocyte-antigen-related protein), a family of receptors that function in the signaling to the actin cytoskeleton during development. Trio functions as a GEF for Rac1, RhoG, and RhoA, and is involved in the regulation of lamellipodia formation, mediating Rac1-dependent cell spreading and migration. The Trio subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271015 [Multi-domain]  Cd Length: 263  Bit Score: 70.00  E-value: 1.36e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKkispFEHQTYCQR--TLREIKILLRFRHENIIGINDIIRAPT----IEQM 98
Cdd:cd14113   9 YSEVAELGRGRFSVVKKCDQRGTKRAVATK----FVNKKLMKRdqVTHELGVLQSLQHPQLVGLLDTFETPTsyilVLEM 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQDLmetdlykLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFGLArvad 175
Cdd:cd14113  85 ADQGRLLDY-------VVRWGNLTEEKIRFYLREILEALQYLHNCRIAHLDLKPENILVDQSLSkptIKLADFGDA---- 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 66932916 176 PDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd14113 154 VQLNTTYYIHQLLGSPEFAAPEIILGNPVSLTS-DLWSIGVLTYVLLS 200
STKc_PKN cd05589
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer ...
136-230 1.38e-13

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase N; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKN has a C-terminal catalytic domain that is highly homologous to PKCs. Its unique N-terminal regulatory region contains antiparallel coiled-coil (ACC) domains. In mammals, there are three PKN isoforms from different genes (designated PKN-alpha, beta, and gamma), which show different enzymatic properties, tissue distribution, and varied functions. PKN can be activated by the small GTPase Rho, and by fatty acids such as arachidonic and linoleic acids. It is involved in many biological processes including cytokeletal regulation, cell adhesion, vesicle transport, glucose transport, regulation of meiotic maturation and embryonic cell cycles, signaling to the nucleus, and tumorigenesis. The PKN subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270741 [Multi-domain]  Cd Length: 326  Bit Score: 70.79  E-value: 1.38e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 136 GLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGfltEYVATRWYRAPEImLNSKGYTKSIDIWSVG 215
Cdd:cd05589 113 GLQFLHEHKIVYRDLKLDNLLLDTEGYVKIADFGLCKEGMGFGDRTS---TFCGTPEFLAPEV-LTDTSYTRAVDWWGLG 188
                        90
                ....*....|....*
gi 66932916 216 CILAEMLSNRPIFPG 230
Cdd:cd05589 189 VLIYEMLVGESPFPG 203
PK_eIF2AK_GCN2_rpt1 cd14012
Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or ...
65-252 1.72e-13

Pseudokinase domain, repeat 1, of eukaryotic translation Initiation Factor 2-Alpha Kinase 4 or General Control Non-derepressible-2; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. EIF2AKs phosphorylate the alpha subunit of eIF-2, resulting in the overall downregulation of protein synthesis. eIF-2 phosphorylation is induced in response to cellular stresses including virus infection, heat shock, nutrient deficiency, and the accummulation of unfolded proteins, among others. There are four distinct kinases that phosphorylate eIF-2 and control protein synthesis under different stress conditions: GCN2, protein kinase regulated by RNA (PKR), heme-regulated inhibitor kinase (HRI), and PKR-like endoplasmic reticulum kinase (PERK). GCN2 is activated by amino acid or serum starvation and UV irradiation. It induces GCN4, a transcriptional activator of amino acid biosynthetic genes, leading to increased production of amino acids under amino acid-deficient conditions. In serum-starved cells, GCN2 activation induces translation of the stress-responsive transcription factor ATF4, while under UV stress, GCN2 triggers transcriptional rescue via NF-kappaB signaling. GCN2 contains an N-terminal RWD, a degenerate kinase-like (repeat 1), the catalytic kinase (repeat 2), a histidyl-tRNA synthetase (HisRS)-like, and a C-terminal ribosome-binding and dimerization (RB/DD) domains. The degenerate pseudokinase domain of GCN2 may function as a regulatory domain. The GCN2 subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270914 [Multi-domain]  Cd Length: 254  Bit Score: 69.31  E-value: 1.72e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  65 CQRTLREIKILLRFRHENIIGI--NDIIRAPTIEQMKdVYIVQDLME-TDLYKLLKT-QHLSNDHICYFLYQILRGLKYI 140
Cdd:cd14012  42 IQLLEKELESLKKLRHPNLVSYlaFSIERRGRSDGWK-VYLLTEYAPgGSLSELLDSvGSVPLDTARRWTLQLLEALEYL 120
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 141 HSANVLHRDLKPSNLLL-----NTTCDLKicDFGLARVADpDHDHTGFLTEYVATRWyRAPEIMLNSKGYTKSIDIWSVG 215
Cdd:cd14012 121 HRNGVVHKSLHAGNVLLdrdagTGIVKLT--DYSLGKTLL-DMCSRGSLDEFKQTYW-LPPELAQGSKSPTRKTDVWDLG 196
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 66932916 216 CILAEMLSNRPIFpgkHYLDQLNHILGILG-SPSQEDL 252
Cdd:cd14012 197 LLFLQMLFGLDVL---EKYTSPNPVLVSLDlSASLQDF 231
STKc_nPKC_theta cd05619
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze ...
128-340 1.74e-13

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C theta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. Although T-cells also express other PKC isoforms, PKC-theta is unique in that upon antigen stimulation, it is translocated to the plasma membrane at the immunological synapse, where it mediates signals essential for T-cell activation. It is essential for TCR-induced proliferation, cytokine production, T-cell survival, and the differentiation and effector function of T-helper (Th) cells, particularly Th2 and Th17. PKC-theta is being developed as a therapeutic target for Th2-mediated allergic inflammation and Th17-mediated autoimmune diseases. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270770 [Multi-domain]  Cd Length: 331  Bit Score: 70.34  E-value: 1.74e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 128 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgflTEYVATRWYRAPEIMLNSKgYTK 207
Cdd:cd05619 110 FYAAEIICGLQFLHSKGIVYRDLKLDNILLDKDGHIKIADFGMCKENMLGDAKT---STFCGTPDYIAPEILLGQK-YNT 185
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 208 SIDIWSVGCILAEMLSNRPIFPGKhyldqlnhilgilgspSQEDLNCIINLKarnyllslphknkvpwNRLFPN-ADSKA 286
Cdd:cd05619 186 SVDWWSFGVLLYEMLIGQSPFHGQ----------------DEEELFQSIRMD----------------NPFYPRwLEKEA 233
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 287 LDLLDKMLTFNPHKRIEVEQAL-AHPYL---------EQYYDPSDEPIAEAPF---KFDME-LDDLPK 340
Cdd:cd05619 234 KDILVKLFVREPERRLGVRGDIrQHPFFreinwealeEREIEPPFKPKVKSPFdcsNFDKEfLNEKPR 301
PTKc_Syk cd05116
Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the ...
89-223 2.01e-13

Catalytic domain of the Protein Tyrosine Kinase, Spleen tyrosine kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Syk is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Syk was first cloned from the spleen, and its function in hematopoietic cells is well-established. It is involved in the signaling downstream of activated receptors (including B-cell and Fc receptors) that contain ITAMs (immunoreceptor tyr activation motifs), leading to processes such as cell proliferation, differentiation, survival, adhesion, migration, and phagocytosis. More recently, Syk expression has been detected in other cell types (including epithelial cells, vascular endothelial cells, neurons, hepatocytes, and melanocytes), suggesting a variety of biological functions in non-immune cells. Syk plays a critical role in maintaining vascular integrity and in wound healing during embryogenesis. It also regulates Vav3, which is important in osteoclast function including bone development. In breast epithelial cells, where Syk acts as a negative regulator for EGFR signaling, loss of Syk expression is associated with abnormal proliferation during cancer development suggesting a potential role as a tumor suppressor. In mice, Syk has been shown to inhibit malignant transformation of mammary epithelial cells induced with murine mammary tumor virus (MMTV). The Syk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133247 [Multi-domain]  Cd Length: 257  Bit Score: 69.22  E-value: 2.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  89 IIRAPTIEQMKDVYIVQDLMETD-LYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKIC 166
Cdd:cd05116  58 IVRMIGICEAESWMLVMEMAELGpLNKFLqKNRHVTEKNITELVHQVSMGMKYLEESNFVHRDLAARNVLLVTQHYAKIS 137
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916 167 DFGLARVADPDHDHtgflteYVA-------TRWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05116 138 DFGLSKALRADENY------YKAqthgkwpVKWY-APECMNYYKFSSKS-DVWSFGVLMWEAFS 193
STKc_MLK2 cd14148
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the ...
31-223 2.06e-13

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK2 is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK) and is also called MAP3K10. MAP3Ks phosphorylate and activate MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK2 is abundant in brain, skeletal muscle, and testis. It functions upstream of the MAPK, c-Jun N-terminal kinase. It binds hippocalcin, a calcium-sensor protein that protects neurons against calcium-induced cell death. Both MLK2 and hippocalcin may be associated with the pathogenesis of Parkinson's disease. MLK2 also binds to normal huntingtin (Htt), which is important in neuronal transcription, development, and survival. MLK2 does not bind to the polyglutamine-expanded Htt, which is implicated in the pathogeneis of Huntington's disease, leading to neuronal toxicity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation. The MLK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 271050 [Multi-domain]  Cd Length: 258  Bit Score: 69.25  E-value: 2.06e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLR-EIKILLRFRHENIIGINDI-IRAPTIeqmkdVYIVQDLM 108
Cdd:cd14148   2 IGVGGFGKVYKGLWRGEEVAVKAARQDPDEDIAVTAENVRqEARLFWMLQHPNIIALRGVcLNPPHL-----CLVMEYAR 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSAN---VLHRDLKPSNLLLN--------TTCDLKICDFGLARvadpd 177
Cdd:cd14148  77 GGALNRALAGKKVPPHVLVNWAVQIARGMNYLHNEAivpIIHRDLKSSNILILepienddlSGKTLKITDFGLAR----- 151
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 66932916 178 HDHTGFLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLS 223
Cdd:cd14148 152 EWHKTTKMSAAGTYAWMAPEVIRLSL-FSKSSDVWSFGVLLWELLT 196
STKc_MAPKAPK2 cd14170
Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated ...
133-324 2.31e-13

Catalytic domain of the Serine/Threonine kinase, Mitogen-activated protein kinase-activated protein kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MAPK-activated protein kinase 2 (MAPKAP2 or MK2) contains an N-terminal proline-rich region that can bind to SH3 domains, a catalytic kinase domain followed by a C-terminal autoinhibitory region that contains nuclear localization (NLS) and nuclear export (NES) signals with a p38 MAPK docking motif that overlaps the NLS. MK2 is a bonafide substrate for the MAPK p38. It is closely related to MK3 and thus far, MK2/3 show indistinguishable substrate specificity. They are mainly involved in the regulation of gene expression and they participate in diverse cellular processes such as endocytosis, cytokine production, cytoskeletal reorganization, cell migration, cell cycle control and chromatin remodeling. They are implicated in inflammation and cance and their substrates include mRNA-AU-rich-element (ARE)-binding proteins (TTP and hnRNP A0), Hsp proteins (Hsp27 and Hsp25) and RSK, among others. MK2/3 are both expressed ubiquitously but MK2 is expressed at significantly higher levels. The MK2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271072 [Multi-domain]  Cd Length: 303  Bit Score: 69.68  E-value: 2.31e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 133 ILRGLKYIHSANVLHRDLKPSNLLLNT---TCDLKICDFGLARVADpdhDHTGFLTEyVATRWYRAPEImLNSKGYTKSI 209
Cdd:cd14170 110 IGEAIQYLHSINIAHRDVKPENLLYTSkrpNAILKLTDFGFAKETT---SHNSLTTP-CYTPYYVAPEV-LGPEKYDKSC 184
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 210 DIWSVGCILAEMLSNRPIFPGKHyldqlnhilGILGSPSQEDlnciiNLKARNYLLSLPHKNKVpwnrlfpnaDSKALDL 289
Cdd:cd14170 185 DMWSLGVIMYILLCGYPPFYSNH---------GLAISPGMKT-----RIRMGQYEFPNPEWSEV---------SEEVKML 241
                       170       180       190
                ....*....|....*....|....*....|....*
gi 66932916 290 LDKMLTFNPHKRIEVEQALAHPYLEQYYDPSDEPI 324
Cdd:cd14170 242 IRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPL 276
PKc_LIMK_like cd14065
Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of ...
31-229 2.35e-13

Catalytic domain of the LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. Members of this subfamily include LIMK, Testicular or testis-specific protein kinase (TESK), and similar proteins. LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270967 [Multi-domain]  Cd Length: 252  Bit Score: 69.06  E-value: 2.35e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQtycQRTLREIKILLRFRHENI---IGIndiirapTIEQMKDVYIVQDL 107
Cdd:cd14065   1 LGKGFFGEVYKVTHRETGKVMVMKELKRFDEQ---RSFLKEVKLMRRLSHPNIlrfIGV-------CVKDNKLNFITEYV 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METDLYKLLKT--QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLK---ICDFGLAR------VADP 176
Cdd:cd14065  71 NGGTLEELLKSmdEQLPWSQRVSLAKDIASGMAYLHSKNIIHRDLNSKNCLVREANRGRnavVADFGLARempdekTKKP 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 177 DHdhtGFLTEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP 229
Cdd:cd14065 151 DR---KKRLTVVGSPYWMAPE-MLRGESYDEKVDVFSFGIVLCEIIGRVPADP 199
STKc_ROCK2 cd05621
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
25-222 2.41e-13

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK2 was the first identified target of activated RhoA, and was found to play a role in stress fiber and focal adhesion formation. It is prominently expressed in the brain, heart, and skeletal muscles. It is implicated in vascular and neurological disorders, such as hypertension and vasospasm of the coronary and cerebral arteries. ROCK2 is also activated by caspase-2 cleavage, resulting in thrombin-induced microparticle generation in response to cell activation. Mice deficient in ROCK2 show intrauterine growth retardation and embryonic lethality because of placental dysfunction. ROCK contains an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain, and is activated via interaction with Rho GTPases. The ROCK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270771 [Multi-domain]  Cd Length: 379  Bit Score: 70.41  E-value: 2.41e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEhqtycqrTLREIKILLRFRHENIIGINDiirAPTIEQM------ 98
Cdd:cd05621  54 YDVVKVIGRGAFGEVQLVRHKASQKVYAMKLLSKFE-------MIKRSDSAFFWEERDIMAFAN---SPWVVQLfcafqd 123
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 -KDVYIVQDLMET-DLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARvadp 176
Cdd:cd05621 124 dKYLYMVMEYMPGgDLVNLMSNYDVPEKWAKFYTAEVVLALDAIHSMGLIHRDVKPDNMLLDKYGHLKLADFGTCM---- 199
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 177 DHDHTGFL--TEYVATRWYRAPEIMLNSKG---YTKSIDIWSVGCILAEML 222
Cdd:cd05621 200 KMDETGMVhcDTAVGTPDYISPEVLKSQGGdgyYGRECDWWSVGVFLFEML 250
STKc_WNK4 cd14033
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze ...
31-226 2.48e-13

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK4 shows a restricted expression pattern and is usually found in epithelial cells. It is expressed in nephrons and in extrarenal tissues including intestine, eye, mammary glands, and prostate. WNK4 regulates a variety of ion transport proteins including apical or basolateral ion transporters, ion channels in the transcellular pathway, and claudins in the paracellular pathway. Mutations in WNK4 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK4 inhibits the activity of the thiazide-sensitive Na-Cl cotransporter (NCC), which is responsible for about 15% of NaCl reabsorption in the kidney. It also inhibits the renal outer medullary potassium channel (ROMK) and decreases its surface expression. Hypertension and hyperkalemia in PHAII patients with WNK4 mutations may be partly due to increased NaCl reabsorption through NCC and impaired renal potassium secretion by ROMK, respectively. The WNK4 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270935 [Multi-domain]  Cd Length: 261  Bit Score: 69.26  E-value: 2.48e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVA-----IKKISPFEHQTYCQrtlrEIKILLRFRHENIIGINDIIRApTIEQMKDVYIVQ 105
Cdd:cd14033   9 IGRGSFKTVYRGLDTETTVEVAwcelqTRKLSKGERQRFSE----EVEMLKGLQHPNIVRFYDSWKS-TVRGHKCIILVT 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETDLYK--LLKTQHLSNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLN-TTCDLKICDFGLARVadpdhDH 180
Cdd:cd14033  84 ELMTSGTLKtyLKRFREMKLKLLQRWSRQILKGLHFLHSRCppILHRDLKCDNIFITgPTGSVKIGDLGLATL-----KR 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 181 TGFLTEYVATRWYRAPEiMLNSKgYTKSIDIWSVG-CILAEMLSNRP 226
Cdd:cd14033 159 ASFAKSVIGTPEFMAPE-MYEEK-YDEAVDVYAFGmCILEMATSEYP 203
STKc_BMPR1a cd14220
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor; ...
31-259 2.85e-13

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IA Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1a, also called Activin receptor-Like Kinase 3 (ALK3), functions as a receptor for bone morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Germline mutations in BMPR1a are associated with an increased risk to Juvenile Polyposis Syndrome, a hamartomatous disorder that may lead to gastrointestinal cancer. BMPR1a may also play an indirect role in the development of hematopoietic stem cells (HSCs) as osteoblasts are a major component of the HSC niche within the bone marrow. BMPR1a belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1a, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1a subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271122 [Multi-domain]  Cd Length: 287  Bit Score: 69.30  E-value: 2.85e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVrvAIKKISPFEHQTYCQRTlrEIKILLRFRHENIIGI--NDIIRAPTIEQMkdvYIVQDLM 108
Cdd:cd14220   3 IGKGRYGEVWMGKWRGEKV--AVKVFFTTEEASWFRET--EIYQTVLMRHENILGFiaADIKGTGSWTQL---YLITDYH 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLLKTQHLSNDHICYFLYQILRGLKYIHS--------ANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHD 179
Cdd:cd14220  76 ENgSLYDFLKCTTLDTRALLKLAYSAACGLCHLHTeiygtqgkPAIAHRDLKSKNILIKKNGTCCIADLGLAVKFNSDTN 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 HTGF-LTEYVATRWYRAPEIM---LNSKGYTKSI--DIWSVGCILAEMlSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 253
Cdd:cd14220 156 EVDVpLNTRVGTKRYMAPEVLdesLNKNHFQAYImaDIYSFGLIIWEM-ARRCVTGGIVEEYQLPYYDMVPSDPSYEDMR 234

                ....*.
gi 66932916 254 CIINLK 259
Cdd:cd14220 235 EVVCVK 240
PHA03207 PHA03207
serine/threonine kinase US3; Provisional
21-311 2.92e-13

serine/threonine kinase US3; Provisional


Pssm-ID: 165473 [Multi-domain]  Cd Length: 392  Bit Score: 70.26  E-value: 2.92e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   21 VGPRYTNLSYIGEGAYG--MVCSAYDNVNKVRVAIKKISPfehqtycQRTL-REIKILLRFRHENIIGINDIIRAPTIeq 97
Cdd:PHA03207  90 VRMQYNILSSLTPGSEGevFVCTKHGDEQRKKVIVKAVTG-------GKTPgREIDILKTISHRAIINLIHAYRWKST-- 160
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   98 mkdVYIVQDLMETDLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADp 176
Cdd:PHA03207 161 ---VCMVMPKYKCDLFTYVdRSGPLPLEQAITIQRRLLEALAYLHGRGIIHRDVKTENIFLDEPENAVLGDFGAACKLD- 236
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  177 DHDHTGFLTEYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEML-SNRPIFPGK-----HYLDQLNHILGILGSPSQE 250
Cdd:PHA03207 237 AHPDTPQCYGWSGTLETNSPE-LLALDPYCAKTDIWSAGLVLFEMSvKNVTLFGKQvksssSQLRSIIRCMQVHPLEFPQ 315
                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916  251 DLNCIINLKARNYLLSLPHKNKVP--WNRLFPNADSKAldLLDKMLTFNPHKRIEVEQALAHP 311
Cdd:PHA03207 316 NGSTNLCKHFKQYAIVLRPPYTIPpvIRKYGMHMDVEY--LIAKMLTFDQEFRPSAQDILSLP 376
PTKc_FAK cd05056
Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the ...
31-223 3.21e-13

Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. FAK is a cytoplasmic (or nonreceptor) PTK that contains an autophosphorylation site and a FERM domain at the N-terminus, a central tyr kinase domain, proline-rich regions, and a C-terminal FAT (focal adhesion targeting) domain. FAK activity is dependent on integrin-mediated cell adhesion, which facilitates N-terminal autophosphorylation. Full activation is achieved by the phosphorylation of its two adjacent A-loop tyrosines. FAK is important in mediating signaling initiated at sites of cell adhesions and at growth factor receptors. Through diverse molecular interactions, FAK functions as a biosensor or integrator to control cell motility. It is a key regulator of cell survival, proliferation, migration and invasion, and thus plays an important role in the development and progression of cancer. Src binds to autophosphorylated FAK forming the FAK-Src dual kinase complex, which is activated in a wide variety of tumor cells and generates signals promoting growth and metastasis. FAK is being developed as a target for cancer therapy. The FAK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133187 [Multi-domain]  Cd Length: 270  Bit Score: 68.99  E-value: 3.21e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVcsaYDNV------NKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIeqmkdvYIV 104
Cdd:cd05056  14 IGEGQFGDV---YQGVymspenEKIAVAVKTCKNCTSPSVREKFLQEAYIMRQFDHPHIVKLIGVITENPV------WIV 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMET-DLYKLLKTQHLSNDH--ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADpDHDHt 181
Cdd:cd05056  85 MELAPLgELRSYLQVNKYSLDLasLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSPDCVKLGDFGLSRYME-DESY- 162
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*...
gi 66932916 182 gflteYVATR------WYrAPEiMLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05056 163 -----YKASKgklpikWM-APE-SINFRRFTSASDVWMFGVCMWEILM 203
STKc_PKB cd05571
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer ...
120-314 3.73e-13

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. There are three PKB isoforms from different genes, PKB-alpha (or Akt1), PKB-beta (or Akt2), and PKB-gamma (or Akt3). PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. It is activated downstream of phosphoinositide 3-kinase (PI3K) and plays important roles in diverse cellular functions including cell survival, growth, proliferation, angiogenesis, motility, and migration. PKB also has a central role in a variety of human cancers, having been implicated in tumor initiation, progression, and metastasis. The PKB subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and PI3K.


Pssm-ID: 270723 [Multi-domain]  Cd Length: 322  Bit Score: 69.31  E-value: 3.73e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 120 HLSNDHIC------YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgflTEYVATRWY 193
Cdd:cd05571  85 HLSRERVFsedrtrFYGAEIVLALGYLHSQGIVYRDLKLENLLLDKDGHIKITDFGLCKEEISYGATT---KTFCGTPEY 161
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 194 RAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsQEDLNciinlkarnyllslphknkv 273
Cdd:cd05571 162 LAPEVLEDND-YGRAVDWWGLGVVMYEMMCGRLPFYNRDHEVLFELIL-------MEEVR-------------------- 213
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 274 pwnrlFPNADSK-ALDLLDKMLTFNPHKRI-----EVEQALAHPYLE 314
Cdd:cd05571 214 -----FPSTLSPeAKSLLAGLLKKDPKKRLgggprDAKEIMEHPFFA 255
STKc_Unc-89_rpt2 cd14112
Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated ...
24-313 3.94e-13

Catalytic kinase domain, second repeat, of the Giant Serine/Threonine Kinase Uncoordinated protein 89; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The nematode Unc-89 gene, through alternative promoter use and splicing, encodes at least six major isoforms (Unc-89A to Unc-89F) of giant muscle proteins that are homologs for the vetebrate obscurin. In flies, five isoforms of Unc-89 have been detected: four in the muscles of adult flies (two in the indirect flight muscle and two in other muscles) and another isoform in the larva. Unc-89 in nematodes is required for normal muscle cell architecture. In flies, it is necessary for the development of a symmetrical sarcomere in the flight muscles. Unc-89 proteins contain several adhesion and signaling domains including multiple copies of the immunoglobulin (Ig) domain, as well as fibronectin type III (FN3), SH3, RhoGEF, and PH domains. The nematode Unc-89 isoforms D, C, D, and F contain two kinase domain with B and F having two complete kinase domains while the first repeat of C and D are partial domains. Homology modeling suggests that the first kinase repeat of Unc-89 may be catalytically inactive, a pseudokinase, while the second kinase repeat may be active. The Unc-89 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271014 [Multi-domain]  Cd Length: 259  Bit Score: 68.71  E-value: 3.94e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKV-RVAIKKIspFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIeqmkdVY 102
Cdd:cd14112   4 RFSFGSEIFRGRFSVIVKAVDSTTETdAHCAVKI--FEVSDEASEAVREFESLRTLQHENVQRLIAAFKPSNF-----AY 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLLKTQH-LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNT--TCDLKICDFGLARVADPdhd 179
Cdd:cd14112  77 LVMEKLQEDVFTRFSSNDyYSEEQVATTVRQILDALHYLHFKGIAHLDVQPDNIMFQSvrSWQVKLVDFGRAQKVSK--- 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 hTGFLTEYVATRWyRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhyldqlnhilgilGSPSQEDLNCIINLK 259
Cdd:cd14112 154 -LGKVPVDGDTDW-ASPEFHNPETPITVQSDIWGLGVLTFCLLSGFHPFTSE-------------YDDEEETKENVIFVK 218
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 66932916 260 ARnyllslphknkvpWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14112 219 CR-------------PNLIFVEATQEALRFATWALKKSPTRRMRTDEALEHRWL 259
STKc_BMPR1 cd14144
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; ...
31-261 4.15e-13

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type I Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1 functions as a receptor for morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Vertebrates contain two type I BMP receptors, BMPR1a and BMPR1b. BMPR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that also includes TGFbeta, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271046 [Multi-domain]  Cd Length: 287  Bit Score: 69.04  E-value: 4.15e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAydNVNKVRVAIKKISPFEHQTYCQRTlrEIKILLRFRHENIIGI--NDIIRAPTIEQMkdvYIVQDLM 108
Cdd:cd14144   3 VGKGRYGEVWKG--KWRGEKVAVKIFFTTEEASWFRET--EIYQTVLMRHENILGFiaADIKGTGSWTQL---YLITDYH 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLLKTQHLSNDHICYFLYQILRGLKYIHS--------ANVLHRDLKPSNLLL--NTTCdlKICDFGLARVADPD 177
Cdd:cd14144  76 ENgSLYDFLRGNTLDTQSMLKLAYSAACGLAHLHTeifgtqgkPAIAHRDIKSKNILVkkNGTC--CIADLGLAVKFISE 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HDHTGF-LTEYVATRWYRAPEIM---LNSKGYT--KSIDIWSVGCILAEMlSNRPIFPGKHYLDQLNHILGILGSPSQED 251
Cdd:cd14144 154 TNEVDLpPNTRVGTKRYMAPEVLdesLNRNHFDayKMADMYSFGLVLWEI-ARRCISGGIVEEYQLPYYDAVPSDPSYED 232
                       250
                ....*....|
gi 66932916 252 LNCIINLKAR 261
Cdd:cd14144 233 MRRVVCVERR 242
STKc_PKB_gamma cd05593
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); ...
28-232 5.33e-13

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B gamma (also called Akt3); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-gamma is predominantly expressed in neuronal tissues. Mice deficient in PKB-gamma show a reduction in brain weight due to the decreases in cell size and cell number. PKB-gamma has also been shown to be upregulated in estrogen-deficient breast cancer cells, androgen-independent prostate cancer cells, and primary ovarian tumors. It acts as a key mediator in the genesis of ovarian cancer. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-gamma subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270745 [Multi-domain]  Cd Length: 348  Bit Score: 69.34  E-value: 5.33e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGMVCSAYDNVNKVRVAIK--KISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptieQMKD--VYI 103
Cdd:cd05593  20 LKLLGKGTFGKVILVREKASGKYYAMKilKKEVIIAKDEVAHTLTESRVLKNTRHPFLTSLKYSF------QTKDrlCFV 93
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLY-KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDhdhTG 182
Cdd:cd05593  94 MEYVNGGELFfHLSRERVFSEDRTRFYGAEIVSALDYLHSGKIVYRDLKLENLMLDKDGHIKITDFGLCKEGITD---AA 170
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 183 FLTEYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKH 232
Cdd:cd05593 171 TMKTFCGTPEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRlPFYNQDH 220
PTKc_DDR cd05051
Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors; PTKs catalyze ...
31-223 5.48e-13

Catalytic domain of the Protein Tyrosine Kinases, Discoidin Domain Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The DDR subfamily consists of homologs of mammalian DDR1, DDR2, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDRs results in a slow but sustained receptor activation. DDRs regulate cell adhesion, proliferation, and extracellular matrix remodeling. They have been linked to a variety of human cancers including breast, colon, ovarian, brain, and lung. There is no evidence showing that DDRs act as transforming oncogenes. They are more likely to play a role in the regulation of tumor growth and metastasis. The DDR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270644 [Multi-domain]  Cd Length: 297  Bit Score: 68.52  E-value: 5.48e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMV--CSAYD-----------NVNK---VRVAIKKISPFEHQTYCQRTLREIKILLRFRHENII---GI--NDI 89
Cdd:cd05051  13 LGEGQFGEVhlCEANGlsdltsddfigNDNKdepVLVAVKMLRPDASKNAREDFLKEVKIMSQLKDPNIVrllGVctRDE 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  90 IRAPTIEQMK--DV--YIVQDLMETDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKI 165
Cdd:cd05051  93 PLCMIVEYMEngDLnqFLQKHEAETQGASATNSKTLSYGTLLYMATQIASGMKYLESLNFVHRDLATRNCLVGPNYTIKI 172
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 166 CDFGLARVAdpdhdhtgFLTEY--------VATRWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05051 173 ADFGMSRNL--------YSGDYyriegravLPIRWM-AWESILLGKFTTKS-DVWAFGVTLWEILT 228
STKc_TGFbR-like cd13998
Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; ...
31-223 5.55e-13

Catalytic domain of Transforming Growth Factor beta Receptor-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. There are two types of TGFbeta receptors included in this subfamily, I and II, that play different roles in signaling. For signaling to occur, the ligand first binds to the high-affinity type II receptor, which is followed by the recruitment of the low-affinity type I receptor to the complex and its activation through trans-phosphorylation by the type II receptor. The active type I receptor kinase starts intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. Different ligands interact with various combinations of types I and II receptors to elicit a specific signaling pathway. Activins primarily signal through combinations of ACVR1b/ALK7 and ACVR2a/b; myostatin and GDF11 through TGFbR1/ALK4 and ACVR2a/b; BMPs through ACVR1/ALK1 and BMPR2; and TGFbeta through TGFbR1 and TGFbR2. The TGFbR-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270900 [Multi-domain]  Cd Length: 289  Bit Score: 68.62  E-value: 5.55e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSA-YDNVNkvrVAIKkISPFEHQTYCQRTlREIKILLRFRHENIIG-INDIIRAPTIEqmKDVYIVQDLM 108
Cdd:cd13998   3 IGKGRFGEVWKAsLKNEP---VAVK-IFSSRDKQSWFRE-KEIYRTPMLKHENILQfIAADERDTALR--TELWLVTAFH 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLLKTQHLSNDHICYFLYQILRGLKYIHS---------ANVLHRDLKPSNLLL--NTTCdlKICDFGLARVADP 176
Cdd:cd13998  76 PNgSL*DYLSLHTIDWVSLCRLALSVARGLAHLHSeipgctqgkPAIAHRDLKSKNILVknDGTC--CIADFGLAVRLSP 153
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 177 -----DHDHTGflteYVATRWYRAPEIM---LNSKGYT--KSIDIWSVGCILAEMLS 223
Cdd:cd13998 154 stgeeDNANNG----QVGTKRYMAPEVLegaINLRDFEsfKRVDIYAMGLVLWEMAS 206
STKc_CRIK cd05601
Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze ...
101-312 7.23e-13

Catalytic domain of the Serine/Threonine Kinase, Citron Rho-interacting kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. CRIK (also called citron kinase) is an effector of the small GTPase Rho. It plays an important function during cytokinesis and affects its contractile process. CRIK-deficient mice show severe ataxia and epilepsy as a result of abnormal cytokinesis and massive apoptosis in neuronal precursors. A Down syndrome critical region protein TTC3 interacts with CRIK and inhibits CRIK-dependent neuronal differentiation and neurite extension. CRIK contains a catalytic domain, a central coiled-coil domain, and a C-terminal region containing a Rho-binding domain (RBD), a zinc finger, and a pleckstrin homology (PH) domain, in addition to other motifs. The CRIK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270752 [Multi-domain]  Cd Length: 328  Bit Score: 68.49  E-value: 7.23e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLMET-DLYKLLKTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPD 177
Cdd:cd05601  76 LYLVMEYHPGgDLLSLLSRYDdiFEESMARFYLAELVLAIHSLHSMGYVHRDIKPENILIDRTGHIKLADFGSAAKLSSD 155
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 178 HDHTGFLTeyVATRWYRAPEIMLNSKGYTKS-----IDIWSVGCILAEMLSNRPIFPgkhyldqlnhilgilGSPSQEDL 252
Cdd:cd05601 156 KTVTSKMP--VGTPDYIAPEVLTSMNGGSKGtygveCDWWSLGIVAYEMLYGKTPFT---------------EDTVIKTY 218
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 253 NCIINLKArnyLLSLPHKNKVPwnrlfpnadSKALDLLDKMLTfNPHKRIEVEQALAHPY 312
Cdd:cd05601 219 SNIMNFKK---FLKFPEDPKVS---------ESAVDLIKGLLT-DAKERLGYEGLCCHPF 265
STKc_SRPK2 cd14217
Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2; STKs ...
24-313 8.32e-13

Catalytic domain of the Serine/Threonine Kinase, Serine-aRginine Protein Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SRPK2 mediates neuronal cell cycle and cell death through regulation of nuclear cyclin D1. It has also been found to promote leukemia cell proliferation by regulating cyclin A1. SRPK2 also plays a role in regulating pre-mRNA splicing and is required for spliceosomal B complex formation. SRPKs phosphorylate and regulate splicing factors from the SR protein family by specifically phosphorylating multiple serine residues residing in SR/RS dipeptide motifs (also known as RS domains). Phosphorylation of the RS domains enhances interaction with transportin SR and facilitates entry of the SR proteins into the nucleus. SRPKs contain a nonconserved insert domain, within the well-conserved catalytic kinase domain, that regulates their subcellular localization. The SRPK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271119 [Multi-domain]  Cd Length: 366  Bit Score: 68.90  E-value: 8.32e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHqtYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMK---- 99
Cdd:cd14217  13 RYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQH--YTETALDEIKLLRCVRESDPEDPNKDMVVQLIDDFKisgm 90
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 ---DVYIVQDLMETDLYK-LLKT--QHLSNDHICYFLYQILRGLKYIHS-ANVLHRDLKPSNLLL--------------- 157
Cdd:cd14217  91 ngiHVCMVFEVLGHHLLKwIIKSnyQGLPIRCVKSIIRQVLQGLDYLHSkCKIIHTDIKPENILMcvddayvrrmaaeat 170
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 158 ---------------NTTCDL---------------KICDFGLARVAdpdHDHtgfLTEYVATRWYRAPEIMLNSkGYTK 207
Cdd:cd14217 171 ewqkagapppsgsavSTAPDLlvnpldprnadkirvKIADLGNACWV---HKH---FTEDIQTRQYRSIEVLIGA-GYST 243
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 208 SIDIWSVGCILAEMLSNRPIF---PGKHYL---DQLNHILGILGS-PSQEDLNCIINLKARNYLLSLPHKNKV-PWNRL- 278
Cdd:cd14217 244 PADIWSTACMAFELATGDYLFephSGEDYSrdeDHIAHIIELLGCiPRHFALSGKYSREFFNRRGELRHITKLkPWSLFd 323
                       330       340       350       360
                ....*....|....*....|....*....|....*....|...
gi 66932916 279 -------FPNADSKAL-DLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14217 324 vlvekygWPHEDAAQFtDFLIPMLEMVPEKRASAGECLRHPWL 366
PTKc_c-ros cd05044
Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the ...
30-278 9.01e-13

Catalytic domain of the Protein Tyrosine Kinase, C-ros; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. This subfamily contains c-ros, Sevenless, and similar proteins. The proto-oncogene c-ros encodes an orphan receptor PTK (RTK) with an unknown ligand. RTKs contain an extracellular ligand-binding domain, a transmembrane region, and an intracellular tyr kinase domain. RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. C-ros is expressed in embryonic cells of the kidney, intestine and lung, but disappears soon after birth. It persists only in the adult epididymis. Male mice bearing inactive mutations of c-ros lack the initial segment of the epididymis and are infertile. The Drosophila protein, Sevenless, is required for the specification of the R7 photoreceptor cell during eye development. The c-ros subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270640 [Multi-domain]  Cd Length: 268  Bit Score: 67.44  E-value: 9.01e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  30 YIGEGAYGMVCS------AYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGI------NDiiraptieq 97
Cdd:cd05044   2 FLGSGAFGEVFEgtakdiLGDGSGETKVAVKTLRKGATDQEKAEFLKEAHLMSNFKHPNILKLlgvcldND--------- 72
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  98 mkDVYIVQDLMET-DLYKLLKTQHLSNDHICYF----LYQIL----RGLKYIHSANVLHRDLKPSNLLLNTT----CDLK 164
Cdd:cd05044  73 --PQYIILELMEGgDLLSYLRAARPTAFTPPLLtlkdLLSICvdvaKGCVYLEDMHFVHRDLAARNCLVSSKdyreRVVK 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 165 ICDFGLARvadpD---HDH-----TGFLteyvATRWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLS--NRPiFPGKHYL 234
Cdd:cd05044 151 IGDFGLAR----DiykNDYyrkegEGLL----PVRWM-APESLVDGVFTTQS-DVWAFGVLMWEILTlgQQP-YPARNNL 219
                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 66932916 235 DQLNHIL--GILGSPSqedlNCIINLkarnYLLSLPHKNKVPWNRL 278
Cdd:cd05044 220 EVLHFVRagGRLDQPD----NCPDDL----YELMLRCWSTDPEERP 257
PKc_MEK2 cd06649
Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP) ...
133-229 1.02e-12

Catalytic domain of the dual-specificity Protein Kinase, Mitogen-Activated Protein (MAP)/Extracellular signal-Regulated Kinase (ERK) Kinase 2; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine (ST) or tyrosine residues on protein substrates. MEK2 is a dual-specificity PK and a MAPK kinase (MAPKK or MKK) that phosphorylates and activates the downstream targets, ERK1 and ERK2, on specific threonine and tyrosine residues. The ERK cascade starts with extracellular signals including growth factors, hormones, and neurotransmitters, which act through receptors and ion channels to initiate intracellular signaling that leads to the activation at the MAPKKK (Raf-1 or MOS) level, which leads to the transmission of signals to MEK2, and finally to ERK1/2. The ERK cascade plays an important role in cell proliferation, differentiation, oncogenic transformation, and cell cycle control, as well as in apoptosis and cell survival under certain conditions. Gain-of-function mutations in genes encoding ERK cascade proteins, including MEK2, cause cardiofaciocutaneous (CFC) syndrome, a condition leading to multiple congenital anomalies and mental retardation in patients. The MEK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 132980 [Multi-domain]  Cd Length: 331  Bit Score: 68.15  E-value: 1.02e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 133 ILRGLKYIHSAN-VLHRDLKPSNLLLNTTCDLKICDFGLA-RVADpdhdhtGFLTEYVATRWYRAPEiMLNSKGYTKSID 210
Cdd:cd06649 112 VLRGLAYLREKHqIMHRDVKPSNILVNSRGEIKLCDFGVSgQLID------SMANSFVGTRSYMSPE-RLQGTHYSVQSD 184
                        90       100
                ....*....|....*....|
gi 66932916 211 IWSVGCILAEMLSNR-PIFP 229
Cdd:cd06649 185 IWSMGLSLVELAIGRyPIPP 204
STKc_nPKC_delta cd05620
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze ...
101-230 1.10e-12

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C delta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. It slows down cell proliferation, inducing cell cycle arrest and enhancing cell differentiation. PKC-delta is also involved in the regulation of transcription as well as immune and inflammatory responses. It plays a central role in the genotoxic stress response that leads to DNA damaged-induced apoptosis. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-delta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173710 [Multi-domain]  Cd Length: 316  Bit Score: 68.05  E-value: 1.10e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLMETDLYKllktqhlsndhICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
Cdd:cd05620  84 MFHIQDKGRFDLYR-----------ATFYAAEIVCGLQFLHSKGIIYRDLKLDNVMLDRDGHIKIADFGMCKENVFGDNR 152
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 181 TgflTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIFPG 230
Cdd:cd05620 153 A---STFCGTPDYIAPEILQGLK-YTFSVDWWSFGVLLYEMLIGQSPFHG 198
PTKc_Met_Ron cd05058
Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of ...
31-241 1.17e-12

Catalytic domain of the Protein Tyrosine Kinases, Met and Ron; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Met and Ron are receptor PTKs (RTKs) composed of an alpha-beta heterodimer. The extracellular alpha chain is disulfide linked to the beta chain, which contains an extracellular ligand-binding region with a sema domain, a PSI domain and four IPT repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. Met binds to the ligand, hepatocyte growth factor/scatter factor (HGF/SF), and is also called the HGF receptor. HGF/Met signaling plays a role in growth, transformation, cell motility, invasion, metastasis, angiogenesis, wound healing, and tissue regeneration. Aberrant expression of Met through mutations or gene amplification is associated with many human cancers including hereditary papillary renal and gastric carcinomas. The ligand for Ron is macrophage stimulating protein (MSP). Ron signaling is important in regulating cell motility, adhesion, proliferation, and apoptosis. Aberrant Ron expression is implicated in tumorigenesis and metastasis. The Met/Ron subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270649 [Multi-domain]  Cd Length: 262  Bit Score: 67.11  E-value: 1.17e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAY---DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPtiEQMKDVyIVQDL 107
Cdd:cd05058   3 IGKGHFGCVYHGTlidSDGQKIHCAVKSLNRITDIEEVEQFLKEGIIMKDFSHPNVLSLLGICLPS--EGSPLV-VLPYM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METDLYKLLKTQHLS---NDHICYFLyQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPD----HD 179
Cdd:cd05058  80 KHGDLRNFIRSETHNptvKDLIGFGL-QVAKGMEYLASKKFVHRDLAARNCMLDESFTVKVADFGLARdIYDKEyysvHN 158
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 180 HTGfltEYVATRWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLS-NRPIFPGKHYLDQLNHIL 241
Cdd:cd05058 159 HTG---AKLPVKWM-ALESLQTQKFTTKS-DVWSFGVLLWELMTrGAPPYPDVDSFDITVYLL 216
STKc_RIP4_like cd14025
Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar ...
31-244 1.96e-12

Catalytic domain of the Serine/Threonine kinases, Receptor Interacting Protein 4 and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of RIP4, ankyrin (ANK) repeat and kinase domain containing 1 (ANKK1), and similar proteins, all of which harbor C-terminal ANK repeats. RIP4, also called Protein Kinase C-associated kinase (PKK), regulates keratinocyte differentiation and cutaneous inflammation. It activates NF-kappaB and is important in the survival of diffuse large B-cell lymphoma cells. The ANKK1 protein, also called PKK2, has not been studied extensively. The ANKK1 gene, located less than 10kb downstream of the D2 dopamine receptor (DRD2) locus, is altered in the Taq1 A1 polymorphism, which is related to a reduced DRD2 binding affinity and consequently, to mental disorders. The RIP4-like subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270927 [Multi-domain]  Cd Length: 267  Bit Score: 66.75  E-value: 1.96e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKkISPFEHQTYCQRT--LREIKIL--LRFRHenIIGINDIIRAPtieqmkdVYIVQD 106
Cdd:cd14025   4 VGSGGFGQVYKVRHKHWKTWLAIK-CPPSLHVDDSERMelLEEAKKMemAKFRH--ILPVYGICSEP-------VGLVME 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LMET-DLYKLLKTQHLSNDHICYFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGF 183
Cdd:cd14025  74 YMETgSLEKLLASEPLPWELRFRIIHETAVGMNFLHCMKppLLHLDLKPANILLDAHYHVKISDFGLAKWNGLSHSHDLS 153
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916 184 LTEYVATRWYRAPE-IMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhyldqlNHILGIL 244
Cdd:cd14025 154 RDGLRGTIAYLPPErFKEKNRCPDTKHDVYSFAIVIWGILTQKKPFAGE------NNILHIM 209
STKc_MSK_N cd05583
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
108-312 2.33e-12

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, in response to various stimuli such as growth factors, hormones, neurotransmitters, cellular stress, and pro-inflammatory cytokines. This triggers phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) in the C-terminal extension of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. MSKs are predominantly nuclear proteins. They are widely expressed in many tissues including heart, brain, lung, liver, kidney, and pancreas. There are two isoforms of MSK, called MSK1 and MSK2. The MSK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270735 [Multi-domain]  Cd Length: 268  Bit Score: 66.26  E-value: 2.33e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METDLYKllkTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFltEY 187
Cdd:cd05583  86 LFTHLYQ---REHFTESEVRIYIGEIVLALEHLHKLGIIYRDIKLENILLDSEGHVVLTDFGLSKEFLPGENDRAY--SF 160
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 188 VATRWYRAPEIML-NSKGYTKSIDIWSVGCILAEMLSNRPIFPGKhylDQLNhilgilgspSQEDLnciinlkARNYLls 266
Cdd:cd05583 161 CGTIEYMAPEVVRgGSDGHDKAVDWWSLGVLTYELLTGASPFTVD---GERN---------SQSEI-------SKRIL-- 219
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 267 lphKNKVPWNRLFpnaDSKALDLLDKMLTFNPHKRI-----EVEQALAHPY 312
Cdd:cd05583 220 ---KSHPPIPKTF---SAEAKDFILKLLEKDPKKRLgagprGAHEIKEHPF 264
STKc_myosinIIIB_N cd06639
N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze ...
31-314 2.60e-12

N-terminal Catalytic domain of the Serine/Threonine Kinase, Class IIIB myosin; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Class IIIB myosin is expressed highly in retina. It is also present in the brain and testis. The human class IIIB myosin gene maps to a region that overlaps the locus for Bardet-Biedl syndrome, which is characterized by dysmorphic extremities, retinal dystrophy, obesity, male hypogenitalism, and renal abnormalities. Class III myosins are motor proteins containing an N-terminal kinase catalytic domain and a C-terminal actin-binding domain. They may play an important role in maintaining the structural integrity of photoreceptor cell microvilli. They may also function as cargo carriers during light-dependent translocation, in photoreceptor cells, of proteins such as transducin and arrestin. The class III myosin subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270808 [Multi-domain]  Cd Length: 291  Bit Score: 66.55  E-value: 2.60e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTycQRTLREIKILLRF-RHENIIGINDIIRAPTIEQMKDVYIVQDLME 109
Cdd:cd06639  30 IGKGTYGKVYKVTNKKDGSLAAVKILDPISDVD--EEIEAEYNILRSLpNHPNVVKFYGMFYKADQYVGGQLWLVLELCN 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 ----TDLYK--LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLarvadpdhdhTGF 183
Cdd:cd06639 108 ggsvTELVKglLKCGQRLDEAMISYILYGALLGLQHLHNNRIIHRDVKGNNILLTTEGGVKLVDFGV----------SAQ 177
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 184 LTE-------YVATRWYRAPEIMLNSKGYTKS----IDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIlgilgspsqedl 252
Cdd:cd06639 178 LTSarlrrntSVGTPFWMAPEVIACEQQYDYSydarCDVWSLGITAIELADGDPPLFDMHPVKALFKI------------ 245
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916 253 nciinlkARNYLLSLPHKNKvpWNRLFPNadskaldLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd06639 246 -------PRNPPPTLLNPEK--WCRGFSH-------FISQCLIKDFEKRPSVTHLLEHPFIK 291
PKc_LIMK_like_unk cd14156
Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs ...
50-229 2.67e-12

Catalytic domain of an unknown subfamily of LIM domain kinase-like protein kinases; PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine or tyrosine residues on protein substrates. This group is composed of uncharacterized proteins with similarity to LIMK and Testicular or testis-specific protein kinase (TESK). LIMKs are characterized as serine/threonine kinases (STKs) while TESKs are dual-specificity protein kinases. Both LIMK and TESK phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They are implicated in many cellular functions including cell spreading, motility, morphogenesis, meiosis, mitosis, and spermatogenesis. The LIMK-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271058 [Multi-domain]  Cd Length: 256  Bit Score: 66.00  E-value: 2.67e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  50 RVAIKKIspFEHQTYCQRTLREIKILLRFRHENI-----IGINDIIRAPTIEqmkdvYIVQDLMEtdlyKLLKTQHLSnd 124
Cdd:cd14156  19 KVMVVKI--YKNDVDQHKIVREISLLQKLSHPNIvrylgICVKDEKLHPILE-----YVSGGCLE----ELLAREELP-- 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 125 hICY-----FLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLK---ICDFGLARV------ADPDHDHTgflteYVAT 190
Cdd:cd14156  86 -LSWrekveLACDISRGMVYLHSKNIYHRDLNSKNCLIRVTPRGReavVTDFGLAREvgempaNDPERKLS-----LVGS 159
                       170       180       190
                ....*....|....*....|....*....|....*....
gi 66932916 191 RWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSNRPIFP 229
Cdd:cd14156 160 AFWMAPE-MLRGEPYDRKVDVFSFGIVLCEILARIPADP 197
STKc_PIM1 cd14100
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
18-222 2.70e-12

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are two PIM1 isoforms resulting from alternative translation initiation sites. PIM1 is the founding member of the PIM subfamily. It is involved in regulating cell growth, differentiation, and apoptosis. It promotes cancer development when overexpressed by inhibiting apoptosis, promoting cell proliferation, and promoting genomic instability. The PIM1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271002 [Multi-domain]  Cd Length: 254  Bit Score: 66.15  E-value: 2.70e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  18 VFDVGPrytnlsYIGEGAYGMVCSAYDNVNKVRVAIK-----KISPFEHQTYCQRTLREIKILLRFRHeniiGINDIIRA 92
Cdd:cd14100   1 QYQVGP------LLGSGGFGSVYSGIRVADGAPVAIKhvekdRVSEWGELPNGTRVPMEIVLLKKVGS----GFRGVIRL 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  93 PTIEQMKDVYIVqdLME-----TDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKI 165
Cdd:cd14100  71 LDWFERPDSFVL--VLErpepvQDLFDFITERgALPEELARSFFRQVLEAVRHCHNCGVLHRDIKDENILIDlNTGELKL 148
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 166 CDFGL-ARVADPDHdhtgflTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEML 222
Cdd:cd14100 149 IDFGSgALLKDTVY------TDFDGTRVYSPPEWIRFHRYHGRSAAVWSLGILLYDMV 200
STKc_nPKC_eta cd05590
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the ...
106-241 3.11e-12

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C eta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-eta is predominantly expressed in squamous epithelia, where it plays a crucial role in the signaling of cell-type specific differentiation. It is also expressed in pro-B cells and early-stage thymocytes, and acts as a key regulator in early B-cell development. PKC-eta increases glioblastoma multiforme (GBM) proliferation and resistance to radiation, and is being developed as a therapeutic target for the management of GBM. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-eta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270742 [Multi-domain]  Cd Length: 323  Bit Score: 66.85  E-value: 3.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMetdlYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARvadpDHDHTGFLT 185
Cdd:cd05590  82 DLM----FHIQKSRRFDEARARFYAAEITSALMFLHDKGIIYRDLKLDNVLLDHEGHCKLADFGMCK----EGIFNGKTT 153
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 186 E-YVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHIL 241
Cdd:cd05590 154 StFCGTPDYIAPEI-LQEMLYGPSVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAIL 209
STKc_nPKC_theta_like cd05592
Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and ...
132-230 3.14e-12

Catalytic domain of the Serine/Threonine Kinases, Novel Protein Kinase C theta, delta, and similar proteins; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-theta is selectively expressed in T-cells and plays an important and non-redundant role in several aspects of T-cell biology. PKC-delta plays a role in cell cycle regulation and programmed cell death in many cell types. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. There are four nPKC isoforms, delta, epsilon, eta, and theta. The nPKC-theta-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270744 [Multi-domain]  Cd Length: 320  Bit Score: 66.64  E-value: 3.14e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgflTEYVATRWYRAPEIMLNSKgYTKSIDI 211
Cdd:cd05592 104 EIICGLQFLHSRGIIYRDLKLDNVLLDREGHIKIADFGMCKENIYGENKA---STFCGTPDYIAPEILKGQK-YNQSVDW 179
                        90
                ....*....|....*....
gi 66932916 212 WSVGCILAEMLSNRPIFPG 230
Cdd:cd05592 180 WSFGVLLYEMLIGQSPFHG 198
STKc_LATS2 cd05626
Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2; STKs ...
25-228 3.27e-12

Catalytic domain of the Protein Serine/Threonine Kinase, Large Tumor Suppressor 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS2 is an essential mitotic regulator responsible for coordinating accurate cytokinesis completion and governing the stabilization of other mitotic regulators. It is also critical in the maintenance of proper chromosome number, genomic stability, mitotic fidelity, and the integrity of centrosome duplication. Downregulation of LATS2 is associated with poor prognosis in acute lymphoblastic leukemia and breast cancer. The LATS2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173715 [Multi-domain]  Cd Length: 381  Bit Score: 66.96  E-value: 3.27e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAydnvnkvrvaiKKISpfEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIE-------- 96
Cdd:cd05626   3 FVKIKTLGIGAFGEVCLA-----------CKVD--THALYAMKTLRKKDVLNRNQVAHVKAERDILAEADNEwvvklyys 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 -QMKD-VYIVQDLMET-DLYKLLKTQHLSNDHIC-YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGL-- 170
Cdd:cd05626  70 fQDKDnLYFVMDYIPGgDMMSLLIRMEVFPEVLArFYIAELTLAIESVHKMGFIHRDIKPDNILIDLDGHIKLTDFGLct 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 171 ---------------------------------ARVAD--------PDHDHTGFLTE-YVATRWYRAPEIMLNsKGYTKS 208
Cdd:cd05626 150 gfrwthnskyyqkgshirqdsmepsdlwddvsnCRCGDrlktleqrATKQHQRCLAHsLVGTPNYIAPEVLLR-KGYTQL 228
                       250       260
                ....*....|....*....|
gi 66932916 209 IDIWSVGCILAEMLSNRPIF 228
Cdd:cd05626 229 CDWWSVGVILFEMLVGQPPF 248
STKc_TGFbR2_like cd14055
Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II ...
51-223 3.69e-12

Catalytic domain of the Serine/Threonine Kinase, Transforming Growth Factor beta Type II Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TGFbR2 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. Type II receptors, such as TGFbR2, are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. TGFbR2 acts as the receptor for TGFbeta, which is crucial in growth control and homeostasis in many different tissues. It plays roles in regulating apoptosis and in maintaining the balance between self renewal and cell loss. It also plays a key role in maintaining vascular integrity and in regulating responses to genotoxic stress. Mutations in TGFbR2 can cause aortic aneurysm disorders such as Loeys-Dietz and Marfan syndromes. The TGFbR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270957 [Multi-domain]  Cd Length: 295  Bit Score: 66.25  E-value: 3.69e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  51 VAIKKISPFEHQTYCQRtlREIKILLRFRHENIIginDIIrapTIEQMKDVYIVQDLMETDLYKL------LKTQHLSND 124
Cdd:cd14055  27 VAVKIFPYEEYASWKNE--KDIFTDASLKHENIL---QFL---TAEERGVGLDRQYWLITAYHENgslqdyLTRHILSWE 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 125 HICYFLYQILRGLKYIHSAN---------VLHRDLKPSNLLLNTTCDLKICDFGLARVADP-----DHDHTGflteYVAT 190
Cdd:cd14055  99 DLCKMAGSLARGLAHLHSDRtpcgrpkipIAHRDLKSSNILVKNDGTCVLADFGLALRLDPslsvdELANSG----QVGT 174
                       170       180       190
                ....*....|....*....|....*....|....*...
gi 66932916 191 RWYRAPEIM-----LNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd14055 175 ARYMAPEALesrvnLEDLESFKQIDVYSMALVLWEMAS 212
STKc_A-Raf cd14150
Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) ...
28-242 4.11e-12

Catalytic domain of the Serine/Threonine Kinase, A-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. A-Raf cooperates with C-Raf in regulating ERK transient phosphorylation that is associated with cyclin D expression and cell cycle progression. Mice deficient in A-Raf are born alive but show neurological and intestinal defects. A-Raf demonstrates low kinase activity to MEK, compared with B- and C-Raf, and may also have alternative functions other than in the ERK signaling cascade. It regulates the M2 type pyruvate kinase, a key glycolytic enzyme. It also plays a role in endocytic membrane trafficking. A-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The A-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271052 [Multi-domain]  Cd Length: 265  Bit Score: 65.81  E-value: 4.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGMVCSAYDNvNKVRVAIKKIS-PFEHQTycQRTLREIKILLRFRHENIIGINDIIRAPTIeqmkdVYIVQD 106
Cdd:cd14150   5 LKRIGTGSFGTVFRGKWH-GDVAVKILKVTePTPEQL--QAFKNEMQVLRKTRHVNILLFMGFMTRPNF-----AIITQW 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LMETDLYKLLKTQHLSND--HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARvadpdhdhtgfl 184
Cdd:cd14150  77 CEGSSLYRHLHVTETRFDtmQLIDVARQTAQGMDYLHAKNIIHRDLKSNNIFLHEGLTVKIGDFGLAT------------ 144
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916 185 teyVATRW--------------YRAPEI--MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 242
Cdd:cd14150 145 ---VKTRWsgsqqveqpsgsilWMAPEVirMQDTNPYSFQSDVYAYGVVLYELMSGTLPYSNINNRDQIIFMVG 215
STKc_cPKC_alpha cd05615
Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs ...
106-231 4.16e-12

Catalytic domain of the Serine/Threonine Kinase, Classical Protein Kinase C alpha; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-alpha is expressed in many tissues and is associated with cell proliferation, apoptosis, and cell motility. It plays a role in the signaling of the growth factors PDGF, VEGF, EGF, and FGF. Abnormal levels of PKC-alpha have been detected in many transformed cell lines and several human tumors. In addition, PKC-alpha is required for HER2 dependent breast cancer invasion. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. PKCs undergo three phosphorylations in order to take mature forms. In addition, cPKCs depend on calcium, DAG (1,2-diacylglycerol), and in most cases, phosphatidylserine (PS) for activation. The cPKC-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270766 [Multi-domain]  Cd Length: 341  Bit Score: 66.56  E-value: 4.16e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMetdlYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARvadpDHDHTGFLT 185
Cdd:cd05615  97 DLM----YHIQQVGKFKEPQAVFYAAEISVGLFFLHKKGIIYRDLKLDNVMLDSEGHIKIADFGMCK----EHMVEGVTT 168
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 186 -EYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGK 231
Cdd:cd05615 169 rTFCGTPDYIAPEI-IAYQPYGRSVDWWAYGVLLYEMLAGQPPFDGE 214
PTKc_Kit cd05104
Catalytic domain of the Protein Tyrosine Kinase, Kit; PTKs catalyze the transfer of the ...
129-230 5.58e-12

Catalytic domain of the Protein Tyrosine Kinase, Kit; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Kit is important in the development of melanocytes, germ cells, mast cells, hematopoietic stem cells, the interstitial cells of Cajal, and the pacemaker cells of the GI tract. Kit signaling is involved in major cellular functions including cell survival, proliferation, differentiation, adhesion, and chemotaxis. Mutations in Kit, which result in constitutive ligand-independent activation, are found in human cancers such as gastrointestinal stromal tumor (GIST) and testicular germ cell tumor (TGCT). The aberrant expression of Kit and/or SCF is associated with other tumor types such as systemic mastocytosis and cancers of the breast, neurons, lung, prostate, colon, and rectum. Although the structure of the human Kit catalytic domain is known, it is excluded from this specific alignment model because it contains a deletion in its sequence. Kit is a member of the Platelet Derived Growth Factor Receptor (PDGFR) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of Kit to its ligand, the stem-cell factor (SCF), leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. The Kit subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270682 [Multi-domain]  Cd Length: 375  Bit Score: 66.08  E-value: 5.58e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 129 FLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYrAPEIMLNSKgYTKS 208
Cdd:cd05104 219 FSYQVAKGMEFLASKNCIHRDLAARNILLTHGRITKICDFGLARDIRNDSNYVVKGNARLPVKWM-APESIFECV-YTFE 296
                        90       100
                ....*....|....*....|....
gi 66932916 209 IDIWSVGCILAEMLS--NRPiFPG 230
Cdd:cd05104 297 SDVWSYGILLWEIFSlgSSP-YPG 319
STKc_TBK1 cd13988
Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the ...
31-248 6.51e-12

Catalytic domain of the Serine/Threonine kinase, TANK Binding Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TBK1 is also called T2K and NF-kB-activating kinase. It is widely expressed in most cell types and acts as an IkappaB kinase (IKK)-activating kinase responsible for NF-kB activation in response to growth factors. It plays a role in modulating inflammatory responses through the NF-kB pathway. TKB1 is also a major player in innate immune responses since it functions as a virus-activated kinase necessary for establishing an antiviral state. It phosphorylates IRF-3 and IRF-7, which are important transcription factors for inducing type I interferon during viral infection. In addition, TBK1 may also play roles in cell transformation and oncogenesis. The TBK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270890 [Multi-domain]  Cd Length: 316  Bit Score: 65.59  E-value: 6.51e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVcsaYDNVNKVR---VAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIirAPTIEQMKDVYIVQDL 107
Cdd:cd13988   1 LGQGATANV---FRGRHKKTgdlYAVKVFNNLSFMRPLDVQMREFEVLKKLNHKNIVKLFAI--EEELTTRHKVLVMELC 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METDLYKLLK----TQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL----NTTCDLKICDFGLARVADPDHD 179
Cdd:cd13988  76 PCGSLYTVLEepsnAYGLPESEFLIVLRDVVAGMNHLRENGIVHRDIKPGNIMRvigeDGQSVYKLTDFGAARELEDDEQ 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 htgFLTEYvATRWYRAPEIMLNS-------KGYTKSIDIWSVGCILAE----MLSNRPIFPGKHYLDQLNHIlgILGSPS 248
Cdd:cd13988 156 ---FVSLY-GTEEYLHPDMYERAvlrkdhqKKYGATVDLWSIGVTFYHaatgSLPFRPFEGPRRNKEVMYKI--ITGKPS 229
STKc_GRK4 cd05631
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs ...
31-228 6.75e-12

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 4; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK4 has a limited tissue distribution. It is mainly found in the testis, but is also present in the cerebellum and kidney. It is expressed as multiple splice variants with different domain architectures and is post-translationally palmitoylated and localized in the membrane. GRK4 polymorphisms are associated with hypertension and salt sensitivity, as they cause hyperphosphorylation, desensitization, and internalization of the dopamine 1 (D1) receptor while increasing the expression of the angiotensin II type 1 receptor. GRK4 plays a crucial role in the D1 receptor regulation of sodium excretion and blood pressure. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK4 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173720 [Multi-domain]  Cd Length: 285  Bit Score: 65.40  E-value: 6.75e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKIspfEHQTYCQR-----TLREIKILLRFRHENIIGIndiirAPTIEQMKDVYIVQ 105
Cdd:cd05631   8 LGKGGFGEVCACQVRATGKMYACKKL---EKKRIKKRkgeamALNEKRILEKVNSRFVVSL-----AYAYETKDALCLVL 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETDLYKL----LKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLArVADPDHDHt 181
Cdd:cd05631  80 TIMNGGDLKFhiynMGNPGFDEQRAIFYAAELCCGLEDLQRERIVYRDLKPENILLDDRGHIRISDLGLA-VQIPEGET- 157
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 182 gfLTEYVATRWYRAPEIMLNSKgYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd05631 158 --VRGRVGTVGYMAPEVINNEK-YTFSPDWWGLGCLIYEMIQGQSPF 201
PTKc_FGFR1 cd05098
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs ...
31-230 7.20e-12

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Alternative splicing of FGFR1 transcripts produces a variety of isoforms, which are differentially expressed in cells. FGFR1 binds the ligands, FGF1 and FGF2, with high affinity and has also been reported to bind FGF4, FGF6, and FGF9. FGFR1 signaling is critical in the control of cell migration during embryo development. It promotes cell proliferation in fibroblasts. Nuclear FGFR1 plays a role in the regulation of transcription. Mutations, insertions or deletions of FGFR1 have been identified in patients with Kallman's syndrome (KS), an inherited disorder characterized by hypogonadotropic hypogonadism and loss of olfaction. Aberrant FGFR1 expression has been found in some human cancers including 8P11 myeloproliferative syndrome (EMS), breast cancer, and pancreatic adenocarcinoma. FGFR1 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270678 [Multi-domain]  Cd Length: 302  Bit Score: 65.42  E-value: 7.20e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSA------YDNVNKV-RVAIKKISPFEHQTYCQRTLREIKIL-LRFRHENIIginDIIRAPTieQMKDVY 102
Cdd:cd05098  21 LGEGCFGQVVLAeaigldKDKPNRVtKVAVKMLKSDATEKDLSDLISEMEMMkMIGKHKNII---NLLGACT--QDGPLY 95
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 -IVQDLMETDLYKLLKT-----------------QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLK 164
Cdd:cd05098  96 vIVEYASKGNLREYLQArrppgmeycynpshnpeEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMK 175
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 165 ICDFGLARvadpDHDHTGFLTEYVATRW---YRAPEIMLNsKGYTKSIDIWSVGCILAEM--LSNRPiFPG 230
Cdd:cd05098 176 IADFGLAR----DIHHIDYYKKTTNGRLpvkWMAPEALFD-RIYTHQSDVWSFGVLLWEIftLGGSP-YPG 240
STKc_TGFbR_I cd14056
Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type ...
31-222 7.25e-12

Catalytic domain of the Serine/Threonine Kinases, Transforming Growth Factor beta family Type I Receptors; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. This subfamily is composed of type I receptors for the TGFbeta family of secreted signaling molecules including TGFbeta, bone morphogenetic proteins, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation through trans-phosphorylation by type II receptors, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. They are inhibited by the immunophilin FKBP12, which is thought to control leaky signaling caused by receptor oligomerization in the absence of ligand. The TGFbR-I subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270958 [Multi-domain]  Cd Length: 287  Bit Score: 64.99  E-value: 7.25e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVrvAIKKISPFEHQTYcqrtLREIKI----LLRfrHENIIGI--NDIIRAPTIEQMkdvYIV 104
Cdd:cd14056   3 IGKGRYGEVWLGKYRGEKV--AVKIFSSRDEDSW----FRETEIyqtvMLR--HENILGFiaADIKSTGSWTQL---WLI 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMET-DLYKLLKTQHLSNDHICYFLYQILRGLKYIHSA--------NVLHRDLKPSNLLL--NTTCdlKICDFGLARV 173
Cdd:cd14056  72 TEYHEHgSLYDYLQRNTLDTEEALRLAYSAASGLAHLHTEivgtqgkpAIAHRDLKSKNILVkrDGTC--CIADLGLAVR 149
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 174 ADPDHDHTGFLTEY-VATRWYRAPEIMLNSKGYT-----KSIDIWSVGCILAEML 222
Cdd:cd14056 150 YDSDTNTIDIPPNPrVGTKRYMAPEVLDDSINPKsfesfKMADIYSFGLVLWEIA 204
pk1 PHA03390
serine/threonine-protein kinase 1; Provisional
99-313 8.28e-12

serine/threonine-protein kinase 1; Provisional


Pssm-ID: 223069 [Multi-domain]  Cd Length: 267  Bit Score: 64.88  E-value: 8.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   99 KDVYIVQDLMET-DLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD-LKICDFGLARVAD 175
Cdd:PHA03390  82 KGHVLIMDYIKDgDLFDLLKKEgKLSEAEVKKIIRQLVEALNDLHKHNIIHNDIKLENVLYDRAKDrIYLCDYGLCKIIG 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  176 PDHDHTGflteyvaTRWYRAPEiMLNSKGYTKSIDIWSVGCILAEMLSnrpifpGKHyldqlnhilgilgsPSQEDLNCI 255
Cdd:PHA03390 162 TPSCYDG-------TLDYFSPE-KIKGHNYDVSFDWWAVGVLTYELLT------GKH--------------PFKEDEDEE 213
                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916  256 INLKARNYLLSlphkNKVPWNRlfpNADSKALDLLDKMLTFNPHKR-IEVEQALAHPYL 313
Cdd:PHA03390 214 LDLESLLKRQQ----KKLPFIK---NVSKNANDFVQSMLKYNINYRlTNYNEIIKHPFL 265
STKc_RIP2 cd14026
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze ...
27-228 8.57e-12

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP2, also called RICK or CARDIAK, harbors a C-terminal Caspase Activation and Recruitment domain (CARD) belonging to the Death domain (DD) superfamily. It functions as an effector kinase downstream of the pattern recognition receptors from the Nod-like (NLR) family, Nod1 and Nod2, which recognizes bacterial peptidoglycans released upon infection. RIP2 may also be involved in regulating wound healing and keratinocyte proliferation. RIP kinases serve as essential sensors of cellular stress. The RIP2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270928 [Multi-domain]  Cd Length: 284  Bit Score: 64.94  E-value: 8.57e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  27 NLSYIGEGAYGMVCSAYDNVNKVRVAIK--KISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAP-----TIEQMK 99
Cdd:cd14026   1 DLRYLSRGAFGTVSRARHADWRVTVAIKclKLDSPVGDSERNCLLKEAEILHKARFSYILPILGICNEPeflgiVTEYMT 80
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 DVYIVQDLMETDLYK----LLKTQhlsndhicyFLYQILRGLKYIHSAN--VLHRDLKPSNLLLNTTCDLKICDFGLA-- 171
Cdd:cd14026  81 NGSLNELLHEKDIYPdvawPLRLR---------ILYEIALGVNYLHNMSppLLHHDLKTQNILLDGEFHVKIADFGLSkw 151
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 172 RVADPDHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSI--DIWSVGCILAEMLSNRPIF 228
Cdd:cd14026 152 RQLSISQSRSSKSAPEGGTIIYMPPEEYEPSQKRRASVkhDIYSYAIIMWEVLSRKIPF 210
TOMM_kin_cyc TIGR03903
TOMM system kinase/cyclase fusion protein; This model represents proteins of 1350 in length, ...
50-230 9.60e-12

TOMM system kinase/cyclase fusion protein; This model represents proteins of 1350 in length, in multiple species of Burkholderia, in Acidovorax avenae subsp. citrulli AAC00-1 and Delftia acidovorans SPH-1, and in multiple copies in Sorangium cellulosum, in genomic neighborhoods that include a cyclodehydratase/docking scaffold fusion protein (TIGR03882) and a member of the thiazole/oxazole modified metabolite (TOMM) precursor family TIGR03795. It has a kinase domain in the N-terminal 300 amino acids, followed by a cyclase homology domain, followed by regions without named domain definitions. It is a probable bacteriocin-like metabolite biosynthesis protein. [Cellular processes, Toxin production and resistance]


Pssm-ID: 274846 [Multi-domain]  Cd Length: 1266  Bit Score: 66.41  E-value: 9.60e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916     50 RVAIK--KISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTieqmKDVYIVQDLME-TDLYKLLKTQH-LSNDH 125
Cdd:TIGR03903    5 EVAIKllRTDAPEEEHQRARFRRETALCARLYHPNIVALLDSGEAPP----GLLFAVFEYVPgRTLREVLAADGaLPAGE 80
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916    126 ICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFGLAR----VADPDHDHTGFLTEYVATRWYRAPEi 198
Cdd:TIGR03903   81 TGRLMLQVLDALACAHNQGIVHRDLKPQNIMVSQTGVrphAKVLDFGIGTllpgVRDADVATLTRTTEVLGTPTYCAPE- 159
                          170       180       190
                   ....*....|....*....|....*....|..
gi 66932916    199 MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 230
Cdd:TIGR03903  160 QLRGEPVTPNSDLYAWGLIFLECLTGQRVVQG 191
PTKc_Axl cd05075
Catalytic domain of the Protein Tyrosine Kinase, Axl; PTKs catalyze the transfer of the ...
31-266 1.01e-11

Catalytic domain of the Protein Tyrosine Kinase, Axl; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Axl is widely expressed in a variety of organs and cells including epithelial, mesenchymal, hematopoietic, as well as non-transformed cells. It is important in many cellular functions such as survival, anti-apoptosis, proliferation, migration, and adhesion. Axl was originally isolated from patients with chronic myelogenous leukemia and a chronic myeloproliferative disorder. It is overexpressed in many human cancers including colon, squamous cell, thyroid, breast, and lung carcinomas. Axl is a member of the TAM subfamily, composed of receptor PTKs (RTKs) containing an extracellular ligand-binding region with two immunoglobulin-like domains followed by two fibronectin type III repeats, a transmembrane segment, and an intracellular catalytic domain. Binding to its ligands, Gas6 and protein S, leads to receptor dimerization, autophosphorylation, activation, and intracellular signaling. The Axl subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270660 [Multi-domain]  Cd Length: 277  Bit Score: 64.64  E-value: 1.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMV----CSAYDNVNKVRVAIKKISpfehqtYCQRT-----LREIKILLRFRHENI---IGI------NDIIRA 92
Cdd:cd05075   8 LGEGEFGSVmegqLNQDDSVLKVAVKTMKIA------ICTRSemedfLSEAVCMKEFDHPNVmrlIGVclqnteSEGYPS 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  93 PTI--EQMKDvyivQDLMETDLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDF 168
Cdd:cd05075  82 PVVilPFMKH----GDLHSFLLYSRLGDCpvYLPTQMLVKFMTDIASGMEYLSSKNFIHRDLAARNCMLNENMNVCVADF 157
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 169 GLA-RVADPDHDHTGFLTEyVATRWYRAPEimLNSKGYTKSIDIWSVGCILAEMLS-NRPIFPGKH------YLDQLNHi 240
Cdd:cd05075 158 GLSkKIYNGDYYRQGRISK-MPVKWIAIES--LADRVYTTKSDVWSFGVTMWEIATrGQTPYPGVEnseiydYLRQGNR- 233
                       250       260
                ....*....|....*....|....*.
gi 66932916 241 lgiLGSPSqEDLNCIINLKARNYLLS 266
Cdd:cd05075 234 ---LKQPP-DCLDGLYELMSSCWLLN 255
STKc_GRK3 cd05633
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3; STKs ...
104-237 1.07e-11

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK3, also called beta-adrenergic receptor kinase 2 (beta-ARK2), is widely expressed in many tissues. It is involved in modulating the cholinergic response of airway smooth muscles, and also plays a role in dopamine receptor regulation. GRK3-deficient mice show a lack of olfactory receptor desensitization and altered regulation of the M2 muscarinic airway. GRK3 promoter polymorphisms may also be associated with bipolar disorder. GRK3 contains an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. The GRK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270781 [Multi-domain]  Cd Length: 346  Bit Score: 65.08  E-value: 1.07e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMET-DLYKLLkTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
Cdd:cd05633  86 ILDLMNGgDLHYHL-SQHgvFSEKEMRFYATEIILGLEHMHNRFVVYRDLKPANILLDEHGHVRISDLGLACDFSKKKPH 164
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916 181 TGflteyVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF-----PGKHYLDQL 237
Cdd:cd05633 165 AS-----VGTHGYMAPEVLQKGTAYDSSADWFSLGCMLFKLLRGHSPFrqhktKDKHEIDRM 221
PHA03211 PHA03211
serine/threonine kinase US3; Provisional
61-220 1.08e-11

serine/threonine kinase US3; Provisional


Pssm-ID: 223009 [Multi-domain]  Cd Length: 461  Bit Score: 65.68  E-value: 1.08e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   61 HQTYCQR----------TLREIKILLRFRHeniigindiiraPTIEQMKDVYIVQDLM-------ETDLYKLL--KTQHL 121
Cdd:PHA03211 190 HPDYPQRvvvkagwyasSVHEARLLRRLSH------------PAVLALLDVRVVGGLTclvlpkyRSDLYTYLgaRLRPL 257
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  122 SNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDhTGFLTEYVATRWYRAPEImLN 201
Cdd:PHA03211 258 GLAQVTAVARQLLSAIDYIHGEGIIHRDIKTENVLVNGPEDICLGDFGAACFARGSWS-TPFHYGIAGTVDTNAPEV-LA 335
                        170
                 ....*....|....*....
gi 66932916  202 SKGYTKSIDIWSVGCILAE 220
Cdd:PHA03211 336 GDPYTPSVDIWSAGLVIFE 354
PTKc_InsR_like cd05032
Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer ...
31-223 1.12e-11

Catalytic domain of Insulin Receptor-like Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The InsR subfamily is composed of InsR, Insulin-like Growth Factor-1 Receptor (IGF-1R), and similar proteins. InsR and IGF-1R are receptor PTKs (RTKs) composed of two alphabeta heterodimers. Binding of the ligand (insulin, IGF-1, or IGF-2) to the extracellular alpha subunit activates the intracellular tyr kinase domain of the transmembrane beta subunit. Receptor activation leads to autophosphorylation, stimulating downstream kinase activities, which initiate signaling cascades and biological function. InsR and IGF-1R, which share 84% sequence identity in their kinase domains, display physiologically distinct yet overlapping functions in cell growth, differentiation, and metabolism. InsR activation leads primarily to metabolic effects while IGF-1R activation stimulates mitogenic pathways. In cells expressing both receptors, InsR/IGF-1R hybrids are found together with classical receptors. Both receptors can interact with common adaptor molecules such as IRS-1 and IRS-2. The InsR-like subfamily is part of a larger superfamily that includes the catalytic domains of serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173625 [Multi-domain]  Cd Length: 277  Bit Score: 64.67  E-value: 1.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAY-----DNVNKVRVAIKKIspFEHQTYCQRT--LREIKILLRFRHENI---IGIndiiraptIEQMKD 100
Cdd:cd05032  14 LGQGSFGMVYEGLakgvvKGEPETRVAIKTV--NENASMRERIefLNEASVMKEFNCHHVvrlLGV--------VSTGQP 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLM-ETDLYKLLKTQHLSNDHICYF-----------LYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDF 168
Cdd:cd05032  84 TLVVMELMaKGDLKSYLRSRRPEAENNPGLgpptlqkfiqmAAEIADGMAYLAAKKFVHRDLAARNCMVAEDLTVKIGDF 163
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 169 GLARVAdpdhdhtgFLTEY--------VATRWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05032 164 GMTRDI--------YETDYyrkggkglLPVRWM-APESLKDGVFTTKS-DVWSFGVVLWEMAT 216
PTKc_Btk_Bmx cd05113
Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow ...
26-223 1.21e-11

Catalytic domain of the Protein Tyrosine Kinases, Bruton's tyrosine kinase and Bone marrow kinase on the X chromosome; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Btk and Bmx (also named Etk) are members of the Tec-like subfamily of proteins, which are cytoplasmic (or nonreceptor) PTKs with similarity to Src kinases in that they contain Src homology protein interaction domains (SH3, SH2) N-terminal to the catalytic tyr kinase domain. Unlike Src kinases, most Tec subfamily members except Rlk also contain an N-terminal pleckstrin homology (PH) domain, which binds the products of PI3K and allows membrane recruitment and activation. In addition, Btk contains the Tec homology (TH) domain with proline-rich and zinc-binding regions. Btk is expressed in B-cells, and a variety of myeloid cells including mast cells, platelets, neutrophils, and dendrictic cells. It interacts with a variety of partners, from cytosolic proteins to nuclear transcription factors, suggesting a diversity of functions. Stimulation of a diverse array of cell surface receptors, including antigen engagement of the B-cell receptor, leads to PH-mediated membrane translocation of Btk and subsequent phosphorylation by Src kinase and activation. Btk plays an important role in the life cycle of B-cells including their development, differentiation, proliferation, survival, and apoptosis. Mutations in Btk cause the primary immunodeficiency disease, X-linked agammaglobulinaemia (XLA) in humans. Bmx is primarily expressed in bone marrow and the arterial endothelium, and plays an important role in ischemia-induced angiogenesis. It facilitates arterial growth, capillary formation, vessel maturation, and bone marrow-derived endothelial progenitor cell mobilization. The Btk/Bmx subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173657 [Multi-domain]  Cd Length: 256  Bit Score: 64.13  E-value: 1.21e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  26 TNLSYIGEGAYGMVC-----SAYDnvnkvrVAIKKISpfEHQTYCQRTLREIKILLRFRHENIIGINDIIraptiEQMKD 100
Cdd:cd05113   7 TFLKELGTGQFGVVKygkwrGQYD------VAIKMIK--EGSMSEDEFIEEAKVMMNLSHEKLVQLYGVC-----TKQRP 73
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 101 VYIVQDLMETD-LYKLLKT--QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVAdPD 177
Cdd:cd05113  74 IFIITEYMANGcLLNYLREmrKRFQTQQLLEMCKDVCEAMEYLESKQFLHRDLAARNCLVNDQGVVKVSDFGLSRYV-LD 152
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 66932916 178 HDHTGFLTEYVATRWyRAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05113 153 DEYTSSVGSKFPVRW-SPPEVLMYSKFSSKS-DVWAFGVLMWEVYS 196
STKc_GRK2 cd14223
Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2; STKs ...
104-243 1.23e-11

Catalytic domain of the Serine/Threonine Kinase, G protein-coupled Receptor Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. GRK2, also called beta-adrenergic receptor kinase (beta-ARK) or beta-ARK1, is important in regulating several cardiac receptor responses. It plays a role in cardiac development and in hypertension. Deletion of GRK2 in mice results in embryonic lethality, caused by hypoplasia of the ventricular myocardium. GRK2 also plays important roles in the liver (as a regulator of portal blood pressure), in immune cells, and in the nervous system. Altered GRK2 expression has been reported in several disorders including major depression, schizophrenia, bipolar disorder, and Parkinsonism. GRK2 contains an N-terminal RGS homology (RH) domain, a central catalytic domain, and C-terminal pleckstrin homology (PH) domain that mediates PIP2 and G protein betagamma-subunit translocation to the membrane. GRKs phosphorylate and regulate G protein-coupled receptors (GPCRs), the largest superfamily of cell surface receptors which regulate some part of nearly all physiological functions. Phosphorylated GPCRs bind to arrestins, which prevents further G protein signaling despite the presence of activating ligand. TheGRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271125 [Multi-domain]  Cd Length: 321  Bit Score: 64.68  E-value: 1.23e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMET-DLYKLLkTQH--LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
Cdd:cd14223  81 ILDLMNGgDLHYHL-SQHgvFSEAEMRFYAAEIILGLEHMHSRFVVYRDLKPANILLDEFGHVRISDLGLACDFSKKKPH 159
                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 181 TGflteyVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIF-----PGKHYLDQLNHILGI 243
Cdd:cd14223 160 AS-----VGTHGYMAPEVLQKGVAYDSSADWFSLGCMLFKLLRGHSPFrqhktKDKHEIDRMTLTMAV 222
STKc_LIMK cd14154
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer ...
31-222 1.77e-11

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. Vertebrate have two members, LIMK1 and LIMK2. The LIMK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271056 [Multi-domain]  Cd Length: 272  Bit Score: 63.68  E-value: 1.77e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCS-AYDNVNKVRVaIKKISPFEHQTycQRT-LREIKILLRFRHENIIGINDIIRAPTIEQMKDVYI----V 104
Cdd:cd14154   1 LGKGFFGQAIKvTHRETGEVMV-MKELIRFDEEA--QRNfLKEVKVMRSLDHPNVLKFIGVLYKDKKLNLITEYIpggtL 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETDLYKLLKTQHLSndhicyFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFL 184
Cdd:cd14154  78 KDVLKDMARPLPWAQRVR------FAKDIASGMAYLHSMNIIHRDLNSHNCLVREDKTVVVADFGLARLIVEERLPSGNM 151
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 185 TEY-----------------VATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEML 222
Cdd:cd14154 152 SPSetlrhlkspdrkkrytvVGNPYWMAPE-MLNGRSYDEKVDIFSFGIVLCEII 205
STKc_ROCK cd05596
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
31-222 1.87e-11

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK is also referred to as Rho-associated kinase or simply as Rho kinase. It contains an N-terminal extension, a catalytic kinase domain, and a long C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain. It is activated via interaction with Rho GTPases and is involved in many cellular functions including contraction, adhesion, migration, motility, proliferation, and apoptosis. The ROCK subfamily consists of two isoforms, ROCK1 and ROCK2, which may be functionally redundant in some systems, but exhibit different tissue distributions. Both isoforms are ubiquitously expressed in most tissues, but ROCK2 is more prominent in brain and skeletal muscle while ROCK1 is more pronounced in the liver, testes, and kidney. Studies in knockout mice result in different phenotypes, suggesting that the two isoforms do not compensate for each other during embryonic development. The ROCK subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270747 [Multi-domain]  Cd Length: 352  Bit Score: 64.71  E-value: 1.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFE----HQTYCQRTLREIkillrFRHENiigindiirAPTIEQM-------K 99
Cdd:cd05596  34 IGRGAFGEVQLVRHKSTKKVYAMKLLSKFEmikrSDSAFFWEERDI-----MAHAN---------SEWIVQLhyafqddK 99
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 DVYIVQDLMET-DLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPD- 177
Cdd:cd05596 100 YLYMVMDYMPGgDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFVHRDVKPDNMLLDASGHLKLADFGTCMKMDKDg 179
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 178 --HDHTGflteyVATRWYRAPEImLNSKG----YTKSIDIWSVGCILAEML 222
Cdd:cd05596 180 lvRSDTA-----VGTPDYISPEV-LKSQGgdgvYGRECDWWSVGVFLYEML 224
PKc_TESK cd14155
Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; ...
68-223 1.93e-11

Catalytic domain of the Dual-specificity protein kinase, Testicular protein kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TESK proteins phosphorylate cofilin and induce actin cytoskeletal reorganization. In the Drosphila eye, TESK is required for epithelial cell organization. Mammals contain two TESK proteins, TESK1 and TESK2, which are highly expressed in testis and play roles in spermatogenesis. TESK1 is found in testicular germ cells while TESK2 is expressed mainly in nongerminal Sertoli cells. TESK1 is stimulated by integrin-mediated signaling pathways. It regulates cell spreading and focal adhesion formation. The TESK subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271057 [Multi-domain]  Cd Length: 253  Bit Score: 63.65  E-value: 1.93e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  68 TLREIKILLRFRHENII-------------GINDIIRAPTIEQMKDvyivqdlmetdlykllKTQHLSNDHICYFLYQIL 134
Cdd:cd14155  35 MLREVQLMNRLSHPNILrfmgvcvhqgqlhALTEYINGGNLEQLLD----------------SNEPLSWTVRVKLALDIA 98
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 135 RGLKYIHSANVLHRDLKPSNLLLNTTCD---LKICDFGLARVAdPDHDHTGFLTEYVATRWYRAPEiMLNSKGYTKSIDI 211
Cdd:cd14155  99 RGLSYLHSKGIFHRDLTSKNCLIKRDENgytAVVGDFGLAEKI-PDYSDGKEKLAVVGSPYWMAPE-VLRGEPYNEKADV 176
                       170
                ....*....|..
gi 66932916 212 WSVGCILAEMLS 223
Cdd:cd14155 177 FSYGIILCEIIA 188
STKc_aPKC_iota cd05618
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze ...
112-302 1.95e-11

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C iota; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-iota is directly implicated in carcinogenesis. It is critical to oncogenic signaling mediated by Ras and Bcr-Abl. The PKC-iota gene is the target of tumor-specific gene amplification in many human cancers, and has been identified as a human oncogene. In addition to its role in transformed growth, PKC-iota also promotes invasion, chemoresistance, and tumor cell survival. Expression profiling of PKC-iota is a prognostic marker of poor clinical outcome in several human cancers. PKC-iota also plays a role in establishing cell polarity, and has critical embryonic functions. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270769 [Multi-domain]  Cd Length: 364  Bit Score: 64.67  E-value: 1.95e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 112 LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgflTEYVATR 191
Cdd:cd05618 109 MFHMQRQRKLPEEHARFYSAEISLALNYLHERGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTT---STFCGTP 185
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 192 WYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFpgkhyldqlnhilGILGSPSQEDLNciinlkARNYLLSLPHKN 271
Cdd:cd05618 186 NYIAPEI-LRGEDYGFSVDWWALGVLMFEMMAGRSPF-------------DIVGSSDNPDQN------TEDYLFQVILEK 245
                       170       180       190
                ....*....|....*....|....*....|.
gi 66932916 272 KVpwnRLFPNADSKALDLLDKMLTFNPHKRI 302
Cdd:cd05618 246 QI---RIPRSLSVKAASVLKSFLNKDPKERL 273
STKc_MLCK1 cd14191
Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze ...
31-313 2.55e-11

Catalytic domain of the Serine/Threonine Kinase, Myosin Light Chain Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLCK1 (or MYLK1) phosphorylates myosin regulatory light chain and controls the contraction of smooth muscles. The MLCK1 gene expresses three transcripts in a cell-specific manner: a short MLCK1 which contains three immunoglobulin (Ig)-like and one fibronectin type III (FN3) domains, PEVK and actin-binding regions, and a kinase domain near the C-terminus followed by a regulatory segment containing an autoinhibitory Ca2+/calmodulin binding site; a long MLCK1 containing six additional Ig-like domains at the N-terminus compared to the short MLCK1; and the C-terminal Ig module which results in the expression of telokin in phasic smooth muscles, leading to Ca2+ desensitization by cyclic nucleotides of smooth muscle force. MLCK1 is also responsible for myosin regulatory light chain phosphorylation in nonmuscle cells and may play a role in regulating myosin II ATPase activity. The MLCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271093 [Multi-domain]  Cd Length: 259  Bit Score: 63.10  E-value: 2.55e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYcQRTLREIKILLRFRHENIIGINDiirapTIEQMKDVYIVQDLMET 110
Cdd:cd14191  10 LGSGKFGQVFRLVEKKTKKVWAGKFFKAYSAKEK-ENIRQEISIMNCLHHPKLVQCVD-----AFEEKANIVMVLEMVSG 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 111 -DLYKLLKTQ--HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL--NTTCDLKICDFGLARVAdpdhDHTGFLT 185
Cdd:cd14191  84 gELFERIIDEdfELTERECIKYMRQISEGVEYIHKQGIVHLDLKPENIMCvnKTGTKIKLIDFGLARRL----ENAGSLK 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 186 EYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGkhylDQLNHILGILGSPSqedlnciinlkarnyll 265
Cdd:cd14191 160 VLFGTPEFVAPEV-INYEPIGYATDMWSIGVICYILVSGLSPFMG----DNDNETLANVTSAT----------------- 217
                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 266 slphknkvpW---NRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14191 218 ---------WdfdDEAFDEISDDAKDFISNLLKKDMKARLTCTQCLQHPWL 259
STKc_LRRK2 cd14068
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze ...
30-223 2.61e-11

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK2 is one of two vertebrate LRRKs which show complementary expression in the brain. Mutations in LRRK2, found in the kinase, ROC-COR, and WD40 domains, are linked to both familial and sporadic forms of Parkinson's disease. The most prevalent mutation, G2019S located in the activation loop of the kinase domain, increases kinase activity. The R1441C/G mutations in the GTPase domain have also been reported to influence kinase activity. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270970 [Multi-domain]  Cd Length: 252  Bit Score: 63.05  E-value: 2.61e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  30 YIGEGAYGMVCSAYDNVNKVRVAIkkispFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPT--IEQMKDVYIVQDL 107
Cdd:cd14068   1 LLGDGGFGSVYRAVYRGEDVAVKI-----FNKHTSFRLLRQELVVLSHLHHPSLVALLAAGTAPRmlVMELAPKGSLDAL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METDLYKLLKT-QHlsndhicYFLYQILRGLKYIHSANVLHRDLKPSNLL---LNTTCDL--KICDFGLARvadpdHDHT 181
Cdd:cd14068  76 LQQDNASLTRTlQH-------RIALHVADGLRYLHSAMIIYRDLKPHNVLlftLYPNCAIiaKIADYGIAQ-----YCCR 143
                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 66932916 182 GFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd14068 144 MGIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILT 185
STKc_NDR1 cd05628
Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1; STKs catalyze ...
25-228 2.87e-11

Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR1 (also called STK38) plays a role in proper centrosome duplication. It is highly expressed in thymus, muscle, lung and spleen. It is not an essential protein because mice deficient of NDR1 remain viable and fertile. However, these mice develop T-cell lymphomas and appear to be hypersenstive to carcinogenic treatment. NDR1 appears to also act as a tumor suppressor. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270777 [Multi-domain]  Cd Length: 376  Bit Score: 64.29  E-value: 2.87e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGmvcsaydnvnKVRVAIKKISpfeHQTYCQRTLREIKILLRFRHENIIGINDI-IRAPTIEQMKDVYI 103
Cdd:cd05628   3 FESLKVIGRGAFG----------EVRLVQKKDT---GHVYAMKILRKADMLEKEQVGHIRAERDIlVEADSLWVVKMFYS 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYK-----------LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR 172
Cdd:cd05628  70 FQDKLNLYLIMeflpggdmmtlLMKKDTLTEEETQFYIAETVLAIDSIHQLGFIHRDIKPDNLLLDSKGHVKLSDFGLCT 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 VADPDH--------DHT--------------------------GFLTeyVATRWYRAPEIMLNSkGYTKSIDIWSVGCIL 218
Cdd:cd05628 150 GLKKAHrtefyrnlNHSlpsdftfqnmnskrkaetwkrnrrqlAFST--VGTPDYIAPEVFMQT-GYNKLCDWWSLGVIM 226
                       250
                ....*....|
gi 66932916 219 AEMLSNRPIF 228
Cdd:cd05628 227 YEMLIGYPPF 236
PTKc_DDR2 cd05095
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2; PTKs catalyze ...
31-223 3.15e-11

Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR2 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR2 results in a slow but sustained receptor activation. DDR2 binds mostly to fibrillar collagens as well as collagen X. DDR2 is widely expressed in many tissues with the highest levels found in skeletal muscle, skin, kidney and lung. It is important in cell proliferation and development. Mice, with a deletion of DDR2, suffer from dwarfism and delayed healing of epidermal wounds. DDR2 also contributes to collagen (type I) regulation by inhibiting fibrillogenesis and altering the morphology of collagen fibers. It is also expressed in immature dendritic cells (DCs), where it plays a role in DC activation and function. The DDR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase (PI3K).


Pssm-ID: 270677 [Multi-domain]  Cd Length: 297  Bit Score: 63.47  E-value: 3.15e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMV--CSAyDNVNK---------------VRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGIndiiRAP 93
Cdd:cd05095  13 LGEGQFGEVhlCEA-EGMEKfmdkdfalevsenqpVLVAVKMLRADANKNARNDFLKEIKIMSRLKDPNIIRL----LAV 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  94 TIEQMKDVYIVQDLMETDLYKLLKTQH-------------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTT 160
Cdd:cd05095  88 CITDDPLCMITEYMENGDLNQFLSRQQpegqlalpsnaltVSYSDLRFMAAQIASGMKYLSSLNFVHRDLATRNCLVGKN 167
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 161 CDLKICDFGLARVADPDHDHTGFLTEYVATRWYRAPEIMLNSkgYTKSIDIWSVGCILAEMLS 223
Cdd:cd05095 168 YTIKIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGK--FTTASDVWAFGVTLWETLT 228
PTK_Ryk cd05043
Pseudokinase domain of Ryk (Receptor related to tyrosine kinase); Ryk is a receptor tyr kinase ...
119-223 3.22e-11

Pseudokinase domain of Ryk (Receptor related to tyrosine kinase); Ryk is a receptor tyr kinase (RTK) containing an extracellular region with two leucine-rich motifs, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. The extracellular region of Ryk shows homology to the N-terminal domain of Wnt inhibitory factor-1 (WIF) and serves as the ligand (Wnt) binding domain of Ryk. Ryk is expressed in many different tissues both during development and in adults, suggesting a widespread function. It acts as a chemorepulsive axon guidance receptor of Wnt glycoproteins and is responsible for the establishment of axon tracts during the development of the central nervous system. In addition, studies in mice reveal that Ryk is essential in skeletal, craniofacial, and cardiac development. Thus, it appears Ryk is involved in signal transduction despite its lack of kinase activity. Ryk may function as an accessory protein that modulates the signals coming from catalytically active partner RTKs such as the Eph receptors. The Ryk subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270639 [Multi-domain]  Cd Length: 279  Bit Score: 63.24  E-value: 3.22e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 119 QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYrAPEI 198
Cdd:cd05043 111 QALSTQQLVHMALQIACGMSYLHRRGVIHKDIAARNCVIDDELQVKITDNALSRDLFPMDYHCLGDNENRPIKWM-SLES 189
                        90       100
                ....*....|....*....|....*
gi 66932916 199 MLNsKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05043 190 LVN-KEYSSASDVWSFGVLLWELMT 213
STKc_MSK1_N cd05613
N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated ...
115-330 3.47e-11

N-terminal catalytic domain of the Serine/Threonine Kinase, Mitogen and stress-activated kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MSK1 plays a role in the regulation of translational control and transcriptional activation. It phosphorylates the transcription factors, CREB and NFkB. It also phosphorylates the nucleosomal proteins H3 and HMG-14. Increased phosphorylation of MSK1 is associated with the development of cerebral ischemic/hypoxic preconditioning. MSKs contain an N-terminal kinase domain (NTD) from the AGC family and a C-terminal kinase domain (CTD) from the CAMK family. MSKs are activated by two major signaling cascades, the Ras-MAPK and p38 stress kinase pathways, which trigger phosphorylation in the activation loop (A-loop) of the CTD of MSK. The active CTD phosphorylates the hydrophobic motif (HM) of NTD, which facilitates the phosphorylation of the A-loop and activates the NTD, which in turn phosphorylates downstream targets. The MSK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270764 [Multi-domain]  Cd Length: 290  Bit Score: 63.10  E-value: 3.47e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 115 LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFltEYVATRWYR 194
Cdd:cd05613  96 LSQRERFTENEVQIYIGEIVLALEHLHKLGIIYRDIKLENILLDSSGHVVLTDFGLSKEFLLDENERAY--SFCGTIEYM 173
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 195 APEIMLNSK-GYTKSIDIWSVGCILAEMLSNRPIFPgkhyLDQLNHilgilgspSQEDLnciinlkARNYLLSLPHknkv 273
Cdd:cd05613 174 APEIVRGGDsGHDKAVDWWSLGVLMYELLTGASPFT----VDGEKN--------SQAEI-------SRRILKSEPP---- 230
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916 274 pwnrlFPNADSK-ALDLLDKMLTFNPHKRI-----EVEQALAHPYLEQY-YDPSDEPIAEAPFK 330
Cdd:cd05613 231 -----YPQEMSAlAKDIIQRLLMKDPKKRLgcgpnGADEIKKHPFFQKInWDDLAAKKVPAPFK 289
PTKc_FGFR4 cd05099
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs ...
131-230 3.73e-11

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Unlike other FGFRs, there is only one splice form of FGFR4. It binds FGF1, FGF2, FGF6, FGF19, and FGF23. FGF19 is a selective ligand for FGFR4. Although disruption of FGFR4 in mice causes no obvious phenotype, in vivo inhibition of FGFR4 in cultured skeletal muscle cells resulted in an arrest of muscle progenitor differentiation. FGF6 and FGFR4 are uniquely expressed in myofibers and satellite cells. FGF6/FGFR4 signaling appears to play a key role in the regulation of muscle regeneration. A polymorphism in FGFR4 is found in head and neck squamous cell carcinoma. FGFR4 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133230 [Multi-domain]  Cd Length: 314  Bit Score: 63.44  E-value: 3.73e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 131 YQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHdHTGFLTEYVATRWYrAPEIMLNsKGYTKSI 209
Cdd:cd05099 141 YQVARGMEYLESRRCIHRDLAARNVLVTEDNVMKIADFGLARgVHDIDY-YKKTSNGRLPVKWM-APEALFD-RVYTHQS 217
                        90       100
                ....*....|....*....|...
gi 66932916 210 DIWSVGCILAEM--LSNRPiFPG 230
Cdd:cd05099 218 DVWSFGILMWEIftLGGSP-YPG 239
STKc_WNK3 cd14031
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze ...
31-224 4.08e-11

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK3 shows a restricted expression pattern; it is found at high levels in the pituary glands and is also expressed in the kidney and brain. It has been shown to regulate many ion transporters including members of the SLC12A family of cation-chloride cotransporters such as NCC and NKCC2, the renal potassium channel ROMK, and the epithelial calcium channels TRPV5 and TRPV6. WNK3 appears to sense low-chloride hypotonic stress and under these conditions, it activates SPAK, which directly interacts and phosphorylates cation-chloride cotransporters. WNK3 has also been shown to promote cell survival, possibly through interaction with procaspase-3 and HSP70. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270933 [Multi-domain]  Cd Length: 275  Bit Score: 62.82  E-value: 4.08e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAI-----KKISPFEHQtycqRTLREIKILLRFRHENIIGINDIIRApTIEQMKDVYIVQ 105
Cdd:cd14031  18 LGRGAFKTVYKGLDTETWVEVAWcelqdRKLTKAEQQ----RFKEEAEMLKGLQHPNIVRFYDSWES-VLKGKKCIVLVT 92
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETDL-------YKLLKTQHLSNdhicyFLYQILRGLKYIHSAN--VLHRDLKPSNLLLN-TTCDLKICDFGLARVAd 175
Cdd:cd14031  93 ELMTSGTlktylkrFKVMKPKVLRS-----WCRQILKGLQFLHTRTppIIHRDLKCDNIFITgPTGSVKIGDLGLATLM- 166
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 176 pdhdHTGFLTEYVATRWYRAPEIMlnSKGYTKSIDIWSVGCILAEMLSN 224
Cdd:cd14031 167 ----RTSFAKSVIGTPEFMAPEMY--EEHYDESVDVYAFGMCMLEMATS 209
PTKc_Zap-70 cd05115
Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs ...
31-233 4.34e-11

Catalytic domain of the Protein Tyrosine Kinase, Zeta-chain-associated protein of 70kDa; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Zap-70 is a cytoplasmic (or nonreceptor) PTK containing two Src homology 2 (SH2) domains N-terminal to the catalytic tyr kinase domain. Zap-70 is primarily expressed in T-cells and NK cells, and is a crucial component in T-cell receptor (TCR) signaling. Zap-70 binds the phosphorylated ITAM (immunoreceptor tyr activation motif) sequences of the activated TCR zeta-chain through its SH2 domains, leading to its phosphorylation and activation. It then phosphorylates target proteins, which propagate the signals to downstream pathways. Zap-70 is hardly detected in normal peripheral B-cells, but is present in some B-cell malignancies. It is used as a diagnostic marker for chronic lymphocytic leukemia (CLL) as it is associated with the more aggressive subtype of the disease. The Zap-70 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270686 [Multi-domain]  Cd Length: 269  Bit Score: 62.66  E-value: 4.34e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNK--VRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIgindiiRAPTIEQMKDVYIVQDLM 108
Cdd:cd05115  12 LGSGNFGCVKKGVYKMRKkqIDVAIKVLKQGNEKAVRDEMMREAQIMHQLDNPYIV------RMIGVCEAEALMLVMEMA 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ETD-LYKLL--KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHtgflt 185
Cdd:cd05115  86 SGGpLNKFLsgKKDEITVSNVVELMHQVSMGMKYLEEKNFVHRDLAARNVLLVNQHYAKISDFGLSKALGADDSY----- 160
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 186 eYVAT-------RWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLSnrpiFPGKHY 233
Cdd:cd05115 161 -YKARsagkwplKWY-APECINFRKFSSRS-DVWSYGVTMWEAFS----YGQKPY 208
PTKc_CSF-1R cd05106
Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor; PTKs ...
105-230 4.48e-11

Catalytic domain of the Protein Tyrosine Kinase, Colony-Stimulating Factor-1 Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. CSF-1R, also called c-Fms, is a member of the Platelet Derived Growth Factor Receptor (PDGFR) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with five immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of CSF-1R to its ligand, CSF-1, leads to receptor dimerization, trans phosphorylation and activation, and intracellular signaling. CSF-1R signaling is critical in the regulation of macrophages and osteoclasts. It leads to increases in gene transcription and protein translation, and induces cytoskeletal remodeling. CSF-1R signaling leads to a variety of cellular responses including survival, proliferation, and differentiation of target cells. It plays an important role in innate immunity, tissue development and function, and the pathogenesis of some diseases including atherosclerosis and cancer. CSF-1R signaling is also implicated in mammary gland development during pregnancy and lactation. Aberrant CSF-1/CSF-1R expression correlates with tumor cell invasiveness, poor clinical prognosis, and bone metastasis in breast cancer. Although the structure of the human CSF-1R catalytic domain is known, it is excluded from this specific alignment model because it contains a deletion in its sequence. The CSF-1R subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133237 [Multi-domain]  Cd Length: 374  Bit Score: 63.33  E-value: 4.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDLMETDLYKLLKtqhlsndhicyFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFL 184
Cdd:cd05106 204 EDSWPLDLDDLLR-----------FSSQVAQGMDFLASKNCIHRDVAARNVLLTDGRVAKICDFGLARDIMNDSNYVVKG 272
                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*..
gi 66932916 185 TEYVATRWYrAPEIMLNSKgYTKSIDIWSVGCILAEMLS-NRPIFPG 230
Cdd:cd05106 273 NARLPVKWM-APESIFDCV-YTVQSDVWSYGILLWEIFSlGKSPYPG 317
PK_STRAD cd08216
Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows ...
37-224 4.52e-11

Pseudokinase domain of STE20-related kinase adapter protein; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. STRAD forms a complex with the scaffolding protein MO25, and the serine/threonine kinase (STK), LKB1, resulting in the activation of the kinase. In the complex, LKB1 phosphorylates and activates adenosine monophosphate-activated protein kinases (AMPKs), which regulate cell energy metabolism and cell polarity. LKB1 is a tumor suppressor linked to the rare inherited disease, Peutz-Jeghers syndrome, which is characterized by a predisposition to benign polyps and hyperpigmentation of the buccal mucosa. There are two forms of STRAD, alpha and beta, that complex with LKB1 and MO25. The structure of STRAD-alpha is available and shows that this protein binds ATP, has an ordered activation loop, and adopts a closed conformation typical of fully active protein kinases. It does not possess activity due to nonconservative substitutions of essential catalytic residues. ATP binding enhances the affinity of STRAD for MO25. The conformation of STRAD-alpha stabilized through ATP and MO25 may be needed to activate LKB1. The STRAD subfamily is part of a larger superfamily that includes the catalytic domains of STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270856 [Multi-domain]  Cd Length: 315  Bit Score: 63.08  E-value: 4.52e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  37 GMVCSAYD-NVNKVRVAIKKISpFEHQ--TYCQRTLREIKILLRFRHENIIGINDiirapTIEQMKDVYIVQDLME---- 109
Cdd:cd08216  13 GGVVHLAKhKPTNTLVAVKKIN-LESDskEDLKFLQQEILTSRQLQHPNILPYVT-----SFVVDNDLYVVTPLMAygsc 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA--------RVADPdHDHT 181
Cdd:cd08216  87 RDLLKTHFPEGLPELAIAFILRDVLNALEYIHSKGYIHRSVKASHILISGDGKVVLSGLRYAysmvkhgkRQRVV-HDFP 165
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 66932916 182 GFLTeyVATRWYrAPEIM-LNSKGYTKSIDIWSVGcILAEMLSN 224
Cdd:cd08216 166 KSSE--KNLPWL-SPEVLqQNLLGYNEKSDIYSVG-ITACELAN 205
STKc_PKB_alpha cd05594
Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); ...
112-232 4.69e-11

Catalytic domain of the Serine/Threonine Kinase, Protein Kinase B alpha (also called Akt1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKB-alpha is predominantly expressed in endothelial cells. It is critical for the regulation of angiogenesis and the maintenance of vascular integrity. It also plays a role in adipocyte differentiation. Mice deficient in PKB-alpha exhibit perinatal morbidity, growth retardation, reduction in body weight accompanied by reduced sizes of multiple organs, and enhanced apoptosis in some cell types. PKB-alpha activity has been reported to be frequently elevated in breast and prostate cancers. In some cancer cells, PKB-alpha may act as a suppressor of metastasis. PKB contains an N-terminal pleckstrin homology (PH) domain and a C-terminal catalytic domain. The PKB-alpha subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270746 [Multi-domain]  Cd Length: 356  Bit Score: 63.51  E-value: 4.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 112 LYKLLKTQHLSNDHICYFLYQILRGLKYIHSA-NVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDhdhTGFLTEYVAT 190
Cdd:cd05594 113 FFHLSRERVFSEDRARFYGAEIVSALDYLHSEkNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKD---GATMKTFCGT 189
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 66932916 191 RWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNR-PIFPGKH 232
Cdd:cd05594 190 PEYLAPEV-LEDNDYGRAVDWWGLGVVMYEMMCGRlPFYNQDH 231
STKc_LATS1 cd05625
Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1; STKs catalyze the ...
25-228 5.98e-11

Catalytic domain of the Serine/Threonine Kinase, Large Tumor Suppressor 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LATS1 functions as a tumor suppressor and is implicated in cell cycle regulation. Inactivation of LATS1 in mice results in the development of various tumors, including sarcomas and ovarian cancer. Promoter methylation, loss of heterozygosity, and missense mutations targeting the LATS1 gene have also been found in human sarcomas and ovarian cancers. In addition, decreased expression of LATS1 is associated with an aggressive phenotype and poor prognosis. LATS1 induces G2 arrest and promotes cytokinesis. It may be a component of the mitotic exit network in higher eukaryotes. The LATS1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270775 [Multi-domain]  Cd Length: 382  Bit Score: 63.14  E-value: 5.98e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVrvaikkispfehqTYCQRTLREIKILLRFRHENIIGINDIIRAPTIE-------- 96
Cdd:cd05625   3 FVKIKTLGIGAFGEVCLARKVDTKA-------------LYATKTLRKKDVLLRNQVAHVKAERDILAEADNEwvvrlyys 69
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 -QMKD-VYIVQDLMET-DLYKLLKTQHLSNDHICYF-LYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA- 171
Cdd:cd05625  70 fQDKDnLYFVMDYIPGgDMMSLLIRMGVFPEDLARFyIAELTCAVESVHKMGFIHRDIKPDNILIDRDGHIKLTDFGLCt 149
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 172 -----------RVAD-PDHDHTGFLTEY-------------------------------VATRWYRAPEIMLNSkGYTKS 208
Cdd:cd05625 150 gfrwthdskyyQSGDhLRQDSMDFSNEWgdpencrcgdrlkplerraarqhqrclahslVGTPNYIAPEVLLRT-GYTQL 228
                       250       260
                ....*....|....*....|
gi 66932916 209 IDIWSVGCILAEMLSNRPIF 228
Cdd:cd05625 229 CDWWSVGVILFEMLVGQPPF 248
STKc_phototropin_like cd05574
Catalytic domain of Phototropin-like Serine/Threonine Kinases; STKs catalyze the transfer of ...
31-241 6.13e-11

Catalytic domain of Phototropin-like Serine/Threonine Kinases; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Phototropins are blue-light receptors that control responses such as phototropism, stromatal opening, and chloroplast movement in order to optimize the photosynthetic efficiency of plants. They are light-activated STKs that contain an N-terminal photosensory domain and a C-terminal catalytic domain. The N-terminal domain contains two LOV (Light, Oxygen or Voltage) domains that binds FMN. Photoexcitation of the LOV domains results in autophosphorylation at multiple sites and activation of the catalytic domain. In addition to plant phototropins, included in this subfamily are predominantly uncharacterized fungal STKs whose catalytic domains resemble the phototropin kinase domain. One protein from Neurospora crassa is called nrc-2, which plays a role in growth and development by controlling entry into the conidiation program. The phototropin-like subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270726 [Multi-domain]  Cd Length: 316  Bit Score: 62.64  E-value: 6.13e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTY--CQRTLREIKILLRFRHENIigindiiraPT----IEQMKDVYIV 104
Cdd:cd05574   9 LGKGDVGRVYLVRLKGTGKLFAMKVLDKEEMIKRnkVKRVLTEREILATLDHPFL---------PTlyasFQTSTHLCFV 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 105 QDL-METDLYKLLKTQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA--------- 171
Cdd:cd05574  80 MDYcPGGELFRLLQKQpgkRLPEEVARFYAAEVLLALEYLHLLGFVYRDLKPENILLHESGHIMLTDFDLSkqssvtppp 159
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 172 ------------RVADPDHD----HTGFLT-EYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYL 234
Cdd:cd05574 160 vrkslrkgsrrsSVKSIEKEtfvaEPSARSnSFVGTEEYIAPEV-IKGDGHGSAVDWWTLGILLYEMLYGTTPFKGSNRD 238

                ....*..
gi 66932916 235 DQLNHIL 241
Cdd:cd05574 239 ETFSNIL 245
STKc_aPKC cd05588
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the ...
106-228 6.48e-11

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. aPKCs only require phosphatidylserine (PS) for activation. They contain a C2-like region, instead of a calcium-binding (C2) region found in classical PKCs, in their regulatory domain. There are two aPKC isoforms, zeta and iota. aPKCs are involved in many cellular functions including proliferation, migration, apoptosis, polarity maintenance and cytoskeletal regulation. They also play a critical role in the regulation of glucose metabolism and in the pathogenesis of type 2 diabetes. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. The aPKC subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270740 [Multi-domain]  Cd Length: 328  Bit Score: 62.82  E-value: 6.48e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMetdlYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGflt 185
Cdd:cd05588  82 DLM----FHMQRQRRLPEEHARFYSAEISLALNFLHEKGIIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTS--- 154
                        90       100       110       120
                ....*....|....*....|....*....|....*....|...
gi 66932916 186 EYVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd05588 155 TFCGTPNYIAPEI-LRGEDYGFSVDWWALGVLMFEMLAGRSPF 196
PTZ00283 PTZ00283
serine/threonine protein kinase; Provisional
132-241 6.75e-11

serine/threonine protein kinase; Provisional


Pssm-ID: 240344 [Multi-domain]  Cd Length: 496  Bit Score: 63.35  E-value: 6.75e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV-ADPDHDHTGflTEYVATRWYRAPEIMlNSKGYTKSID 210
Cdd:PTZ00283 151 QVLLAVHHVHSKHMIHRDIKSANILLCSNGLVKLGDFGFSKMyAATVSDDVG--RTFCGTPYYVAPEIW-RRKPYSKKAD 227
                         90       100       110
                 ....*....|....*....|....*....|.
gi 66932916  211 IWSVGCILAEMLSNRPIFPGKHYLDQLNHIL 241
Cdd:PTZ00283 228 MFSLGVLLYELLTLKRPFDGENMEEVMHKTL 258
STKc_LIMK2 cd14222
Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the ...
31-222 7.69e-11

Catalytic domain of the Serine/Threonine Kinase, LIM domain kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LIMK2 activation is induced by transforming growth factor-beta l (TGFb-l) and shares the same subcellular location as the cofilin family member twinfilin, which may be its biological substrate. LIMK2 plays a role in spermatogenesis, and may contribute to tumor progression and metastasis formation in some cancer cells. LIMKs phosphorylate and inactivate cofilin, an actin depolymerizing factor, to induce the reorganization of the actin cytoskeleton. They act downstream of Rho GTPases and are expressed ubiquitously. As regulators of actin dynamics, they contribute to diverse cellular functions such as cell motility, morphogenesis, differentiation, apoptosis, meiosis, mitosis, and neurite extension. LIMKs contain the LIM (two repeats), PDZ, and catalytic kinase domains. The LIMK2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271124 [Multi-domain]  Cd Length: 272  Bit Score: 61.88  E-value: 7.69e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTycQRT-LREIKILLRFRHENI---IGIndiiraptIEQMKDVYIVQD 106
Cdd:cd14222   1 LGKGFFGQAIKVTHKATGKVMVMKELIRCDEET--QKTfLTEVKVMRSLDHPNVlkfIGV--------LYKDKRLNLLTE 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LMETDLYK--LLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV-------ADPD 177
Cdd:cd14222  71 FIEGGTLKdfLRADDPFPWQQKVSFAKGIASGMAYLHSMSIIHRDLNSHNCLIKLDKTVVVADFGLSRLiveekkkPPPD 150
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 178 HDHTGFLT----------EYVATRWYRAPEiMLNSKGYTKSIDIWSVGCILAEML 222
Cdd:cd14222 151 KPTTKKRTlrkndrkkryTVVGNPYWMAPE-MLNGKSYDEKVDIFSFGIVLCEII 204
STKc_NDR2 cd05627
Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2; STKs catalyze ...
25-228 8.57e-11

Catalytic domain of the Serine/Threonine Kinase, Nuclear Dbf2-Related kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. NDR2 (also called STK38-like) plays a role in proper centrosome duplication. In addition, it is involved in regulating neuronal growth and differentiation, as well as in facilitating neurite outgrowth. NDR2 is also implicated in fear conditioning as it contributes to the coupling of neuronal morphological changes with fear-memory consolidation. NDR kinase contains an N-terminal regulatory (NTR) domain and an insert within the catalytic domain that contains an auto-inhibitory sequence. Like many other AGC kinases, NDR kinase requires phosphorylation at two sites, the activation loop (A-loop) and the hydrophobic motif (HM), for activity. The NDR2 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270776 [Multi-domain]  Cd Length: 366  Bit Score: 62.77  E-value: 8.57e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGmvcsaydnvnKVRVAIKKISpfeHQTYCQRTLREIKILLRFRHENIIGINDIIRAP----------T 94
Cdd:cd05627   4 FESLKVIGRGAFG----------EVRLVQKKDT---GHIYAMKILRKADMLEKEQVAHIRAERDILVEAdgawvvkmfyS 70
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  95 IEQMKDVYIVQDLMET-DLYKLL-KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR 172
Cdd:cd05627  71 FQDKRNLYLIMEFLPGgDMMTLLmKKDTLSEEATQFYIAETVLAIDAIHQLGFIHRDIKPDNLLLDAKGHVKLSDFGLCT 150
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 173 --------------VADPDHDHT--GFLTEYVATRW----------------YRAPEIMLNSkGYTKSIDIWSVGCILAE 220
Cdd:cd05627 151 glkkahrtefyrnlTHNPPSDFSfqNMNSKRKAETWkknrrqlaystvgtpdYIAPEVFMQT-GYNKLCDWWSLGVIMYE 229

                ....*...
gi 66932916 221 MLSNRPIF 228
Cdd:cd05627 230 MLIGYPPF 237
STKc_PIM2 cd14101
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
25-314 8.71e-11

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 2; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3); each gene may result in mutliple protein isoforms. There are three PIM2 isoforms resulting from alternative translation initiation sites. PIM2 is highly expressed in leukemia and lymphomas and has been shown to promote the survival and proliferation of tumor cells. The PIM2 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271003 [Multi-domain]  Cd Length: 257  Bit Score: 61.79  E-value: 8.71e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKI--------SPFEHQTYCQRtlrEIKILLRF----RHENIIGINDIIRA 92
Cdd:cd14101   2 YTMGNLLGKGGFGTVYAGHRISDGLQVAIKQIsrnrvqqwSKLPGVNPVPN---EVALLQSVgggpGHRGVIRLLDWFEI 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  93 PtieqmKDVYIVQDLME--TDLYKLLKTQHLSNDHICY-FLYQILRGLKYIHSANVLHRDLKPSNLLLNT-TCDLKICDF 168
Cdd:cd14101  79 P-----EGFLLVLERPQhcQDLFDYITERGALDESLARrFFKQVVEAVQHCHSKGVVHRDIKDENILVDLrTGDIKLIDF 153
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 169 GLARVAdpdhdHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMlsnrpifpgkhyldqlnhILGILGSPS 248
Cdd:cd14101 154 GSGATL-----KDSMYTDFDGTRVYSPPEWILYHQYHALPATVWSLGILLYDM------------------VCGDIPFER 210
                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 66932916 249 QEDLnciinLKARnyllslPHKNKvpwnRLFPNADskalDLLDKMLTFNPHKRIEVEQALAHPYLE 314
Cdd:cd14101 211 DTDI-----LKAK------PSFNK----RVSNDCR----SLIRSCLAYNPSDRPSLEQILLHPWMM 257
STKc_IRAK1 cd14159
Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; ...
31-225 9.99e-11

Catalytic domain of the Serine/Threonine kinase, Interleukin-1 Receptor Associated Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. IRAKs are involved in Toll-like receptor (TLR) and interleukin-1 (IL-1) signalling pathways, and are thus critical in regulating innate immune responses and inflammation. IRAKs contain an N-terminal Death domain (DD), a proST region (rich in serines, prolines, and threonines), a central kinase domain, and a C-terminal domain; IRAK-4 lacks the C-terminal domain. Vertebrates contain four IRAKs (IRAK-1, -2, -3 (or -M), and -4) that display distinct functions and patterns of expression and subcellular distribution, and can differentially mediate TLR signaling. IRAK1 plays a role in the activation of IRF3/7, STAT, and NFkB. It mediates IL-6 and IFN-gamma responses following IL-1 and IL-18 stimulation, respectively. It also plays an essential role in IFN-alpha induction downstream of TLR7 and TLR9. The IRAK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271061 [Multi-domain]  Cd Length: 296  Bit Score: 61.77  E-value: 9.99e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAydNVNKVRVAIKKI---SPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDL 107
Cdd:cd14159   1 IGEGGFGCVYQA--VMRNTEYAVKRLkedSELDWSVVKNSFLTEVEKLSRFRHPNIVDLAGYSAQQGNYCLIYVYLPNGS 78
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METDLYKLLKTQHLSNDHICYFLYQILRGLKYIH--SANVLHRDLKPSNLLLNTTCDLKICDFGLARVA----DPDHDHT 181
Cdd:cd14159  79 LEDRLHCQVSCPCLSWSQRLHVLLGTARAIQYLHsdSPSLIHGDVKSSNILLDAALNPKLGDFGLARFSrrpkQPGMSST 158
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 66932916 182 GFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNR 225
Cdd:cd14159 159 LARTQTVRGTLAYLPEEYVKTGTLSVEIDVYSFGVVLLELLTGR 202
STKc_MASTL cd05610
Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like ...
31-313 1.16e-10

Catalytic domain of the Serine/Threonine Kinase, Microtubule-associated serine/threonine-like kinase (also called greatwall kinase); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The MASTL kinases in this group carry only a catalytic domain, which contains a long insertion relative to MAST kinases. MASTL, also called greatwall kinase (Gwl), is involved in the regulation of mitotic entry, which is controlled by the coordinated activities of protein kinases and opposing protein phosphatases (PPs). The cyclin B/CDK1 complex induces entry into M-phase while PP2A-B55 shows anti-mitotic activity. MASTL/Gwl is activated downstream of cyclin B/CDK1 and indirectly inhibits PP2A-B55 by phosphorylating the small protein alpha-endosulfine (Ensa) or the cAMP-regulated phosphoprotein 19 (Arpp19), resulting in M-phase progression. Gwl kinase may also play roles in mRNA stabilization and DNA checkpoint recovery. The human MASTL gene has also been named FLJ14813; a missense mutation in FLJ14813 is associated with autosomal dominant thrombocytopenia. The MASTL kinase subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270761 [Multi-domain]  Cd Length: 349  Bit Score: 62.20  E-value: 1.16e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIK--KISPFEHQTYCQRTLREIKILLRFRHENIIGIndiirAPTIEQMKDVYIVQD-L 107
Cdd:cd05610  12 ISRGAFGKVYLGRKKNNSKLYAVKvvKKADMINKNMVHQVQAERDALALSKSPFIVHL-----YYSLQSANNVYLVMEyL 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARV------------- 173
Cdd:cd05610  87 IGGDVKSLLHIYgYFDEEMAVKYISEVALALDYLHRHGIIHRDLKPDNMLISNEGHIKLTDFGLSKVtlnrelnmmdilt 166
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 174 ----ADPDHD-------------HTGFLTE--------------------YVATRWYRAPEIMLnSKGYTKSIDIWSVGC 216
Cdd:cd05610 167 tpsmAKPKNDysrtpgqvlslisSLGFNTPtpyrtpksvrrgaarvegerILGTPDYLAPELLL-GKPHGPAVDWWALGV 245
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 217 ILAEMLSNRPIFPGKhyldqlnhilgilgSPSQEDLNCIinlkarnyllslphKNKVPWnrlfPNADSK----ALDLLDK 292
Cdd:cd05610 246 CLFEFLTGIPPFNDE--------------TPQQVFQNIL--------------NRDIPW----PEGEEElsvnAQNAIEI 293
                       330       340
                ....*....|....*....|.
gi 66932916 293 MLTFNPHKRIEVEQALAHPYL 313
Cdd:cd05610 294 LLTMDPTKRAGLKELKQHPLF 314
PTK_CCK4 cd05046
Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; CCK4, also ...
25-223 1.22e-10

Pseudokinase domain of the Protein Tyrosine Kinase, Colon Carcinoma Kinase 4; CCK4, also called protein tyrosine kinase 7 (PTK7), is an orphan receptor PTK (RTK) containing an extracellular region with seven immunoglobulin domains, a transmembrane segment, and an intracellular inactive pseudokinase domain, which shows similarity to tyr kinases but lacks crucial residues for catalytic activity and ATP binding. Studies in mice reveal that CCK4 is essential for neural development. Mouse embryos containing a truncated CCK4 die perinatally and display craniorachischisis, a severe form of neural tube defect. The mechanism of action of the CCK4 pseudokinase is still unknown. Other pseudokinases such as HER3 rely on the activity of partner RTKs. The CCK4 subfamily is part of a larger superfamily that includes other pseudokinases and the catalytic domains of active kinases including PTKs, protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133178 [Multi-domain]  Cd Length: 275  Bit Score: 61.33  E-value: 1.22e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLS---YIGEGAYGMVCSAY-----DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIE 96
Cdd:cd05046   4 RSNLQeitTLGRGEFGEVFLAKakgieEEGGETLVLVKALQKTKDENLQSEFRRELDMFRKLSHKNVVRLLGLCREAEPH 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 QMKDVYIvqDLmeTDLYKLL----------KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKIC 166
Cdd:cd05046  84 YMILEYT--DL--GDLKQFLratkskdeklKPPPLSTKQKVALCTQIALGMDHLSNARFVHRDLAARNCLVSSQREVKVS 159
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 167 DFGLARvaDP-DHDHTGFLTEYVATRWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05046 160 LLSLSK--DVyNSEYYKLRNALIPLRWL-APEAVQEDDFSTKS-DVWSFGVLMWEVFT 213
PTKc_Trk cd05049
Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze ...
31-223 1.28e-10

Catalytic domain of the Protein Tyrosine Kinases, Tropomyosin Related Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Trk subfamily consists of TrkA, TrkB, TrkC, and similar proteins. They are receptor PTKs (RTKs) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding to their ligands, the nerve growth factor (NGF) family of neutrotrophins, leads to Trk receptor oligomerization and activation of the catalytic domain. Trk receptors are mainly expressed in the peripheral and central nervous systems. They play important roles in cell fate determination, neuronal survival and differentiation, as well as in the regulation of synaptic plasticity. Altered expression of Trk receptors is associated with many human diseases. The Trk subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270643 [Multi-domain]  Cd Length: 280  Bit Score: 61.33  E-value: 1.28e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMV----C-SAYDNVNKVRVAIKKI----SPFEHQTYcqrtLREIKILLRFRHENIIGINDIIraptiEQMKDV 101
Cdd:cd05049  13 LGEGAFGKVflgeCyNLEPEQDKMLVAVKTLkdasSPDARKDF----EREAELLTNLQHENIVKFYGVC-----TEGDPL 83
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 102 YIVQDLMET-DLYKLL---------------KTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKI 165
Cdd:cd05049  84 LMVFEYMEHgDLNKFLrshgpdaaflasedsAPGELTLSQLLHIAVQIASGMVYLASQHFVHRDLATRNCLVGTNLVVKI 163
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 166 CDFGLAR-VADPDHDHTGFLTeYVATRWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05049 164 GDFGMSRdIYSTDYYRVGGHT-MLPIRWM-PPESILYRKFTTES-DVWSFGVVLWEIFT 219
STKc_TTBK cd14017
Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase; STKs catalyze the ...
24-193 1.33e-10

Catalytic domain of the Serine/Threonine protein kinase, Tau-Tubulin Kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TTBK is a neuron-specific kinase that phosphorylates the microtubule-associated protein tau and promotes its aggregation. Higher vertebrates contain two TTBK proteins, TTBK1 and TTBK2, both of which have been implicated in neurodegeneration. TTBK1 has been linked to Alzheimer's disease (AD) while TTBK2 is associated with spinocerebellar ataxia type 11 (SCA11). Both AD and SCA11 patients show the presence of neurofibrillary tangles in the brain. The Drosophila TTBK homolog, Asator, is an essential protein that localizes to the mitotic spindle during mitosis and may be involved in regulating microtubule dynamics and function. The TTBK subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270919 [Multi-domain]  Cd Length: 263  Bit Score: 61.12  E-value: 1.33e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  24 RYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKkispFEHQTYCQRTLR----EIKILLRFRHeniigINDIIRAPTIEQMK 99
Cdd:cd14017   1 RWKVVKKIGGGGFGEIYKVRDVVDGEEVAMK----VESKSQPKQVLKmevaVLKKLQGKPH-----FCRLIGCGRTERYN 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 100 dvYIVQDLMETDLYKLLKTQ---HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLL-NTTCDLKIC---DFGLAR 172
Cdd:cd14017  72 --YIVMTLLGPNLAELRRSQprgKFSVSTTLRLGIQILKAIEDIHEVGFLHRDVKPSNFAIgRGPSDERTVyilDFGLAR 149
                       170       180
                ....*....|....*....|....*....
gi 66932916 173 V---ADPDHD-----HTGFlteyVATRWY 193
Cdd:cd14017 150 QytnKDGEVErpprnAAGF----RGTVRY 174
STKc_ROCK1 cd05622
Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein ...
25-222 1.41e-10

Catalytic domain of the Serine/Threonine Kinase, Rho-associated coiled-coil containing protein kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ROCK1 is preferentially expressed in the liver, lung, spleen, testes, and kidney. It mediates signaling from Rho to the actin cytoskeleton. It is implicated in the development of cardiac fibrosis, cardiomyocyte apoptosis, and hyperglycemia. Mice deficient with ROCK1 display eyelids open at birth (EOB) and omphalocele phenotypes due to the disorganization of actin filaments in the eyelids and the umbilical ring. ROCK contains an N-terminal extension, a catalytic kinase domain, and a C-terminal extension, which contains a coiled-coil region encompassing a Rho-binding domain (RBD) and a pleckstrin homology (PH) domain. ROCK is auto-inhibited by the RBD and PH domain interacting with the catalytic domain, and is activated via interaction with Rho GTPases. The ROCK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270772 [Multi-domain]  Cd Length: 405  Bit Score: 61.94  E-value: 1.41e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEhqtycqrTLREIKILLRFRHENIIGINDiirAPTIEQM------ 98
Cdd:cd05622  75 YEVVKVIGRGAFGEVQLVRHKSTRKVYAMKLLSKFE-------MIKRSDSAFFWEERDIMAFAN---SPWVVQLfyafqd 144
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 -KDVYIVQDLMET-DLYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADP 176
Cdd:cd05622 145 dRYLYMVMEYMPGgDLVNLMSNYDVPEKWARFYTAEVVLALDAIHSMGFIHRDVKPDNMLLDKSGHLKLADFGTCMKMNK 224
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 177 DhdhtGFL--TEYVATRWYRAPEIMLNSKG---YTKSIDIWSVGCILAEML 222
Cdd:cd05622 225 E----GMVrcDTAVGTPDYISPEVLKSQGGdgyYGRECDWWSVGVFLYEML 271
PK_GC-A_B cd14042
Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B; The ...
51-221 1.54e-10

Pseudokinase domain of the membrane Guanylate Cyclase receptors, GC-A and GC-B; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity and/or ATP binding. GC-A binds and is activated by the atrial and B-type natriuretic peptides, ANP and BNP, which are important in blood pressure regulation and cardiac pathophysiology. GC-B binds the C-type natriuretic peptide, CNP, which is a potent vasorelaxant and functions in vascular remodeling and bone growth regulation. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC-A/B subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270944 [Multi-domain]  Cd Length: 279  Bit Score: 61.07  E-value: 1.54e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  51 VAIKKIsPFEHQTYCQRTLREIKILLRFRHENI---IGIndIIRAPTIeqmkdvYIV---------QDLMETDLYKLlkt 118
Cdd:cd14042  33 VAIKKV-NKKRIDLTREVLKELKHMRDLQHDNLtrfIGA--CVDPPNI------CILteycpkgslQDILENEDIKL--- 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 119 qhlsnDH--ICYFLYQILRGLKYIH-SANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGfLTEYVATRWYRA 195
Cdd:cd14042 101 -----DWmfRYSLIHDIVKGMHYLHdSEIKSHGNLKSSNCVVDSRFVLKITDFGLHSFRSGQEPPDD-SHAYYAKLLWTA 174
                       170       180       190
                ....*....|....*....|....*....|
gi 66932916 196 PEIM----LNSKGyTKSIDIWSVGCILAEM 221
Cdd:cd14042 175 PELLrdpnPPPPG-TQKGDVYSFGIILQEI 203
PTZ00266 PTZ00266
NIMA-related protein kinase; Provisional
71-237 1.60e-10

NIMA-related protein kinase; Provisional


Pssm-ID: 173502 [Multi-domain]  Cd Length: 1021  Bit Score: 62.45  E-value: 1.60e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916    71 EIKILLRFRHENIIGINDIIRAPTIEQMkdvYIVQDLMET-DLYKllktqhlsNDHICYFLY-------------QILRG 136
Cdd:PTZ00266   62 EVNVMRELKHKNIVRYIDRFLNKANQKL---YILMEFCDAgDLSR--------NIQKCYKMFgkieehaivditrQLLHA 130
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916   137 LKYIHS-------ANVLHRDLKPSNLLLNTTCD-----------------LKICDFGLAR-VADPDHDHTgflteYVATR 191
Cdd:PTZ00266  131 LAYCHNlkdgpngERVLHRDLKPQNIFLSTGIRhigkitaqannlngrpiAKIGDFGLSKnIGIESMAHS-----CVGTP 205
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 66932916   192 WYRAPEIMLN-SKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQL 237
Cdd:PTZ00266  206 YYWSPELLLHeTKSYDDKSDMWALGCIIYELCSGKTPFHKANNFSQL 252
STKc_BMPR1b cd14219
Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB; STKs ...
31-259 1.96e-10

Catalytic domain of the Serine/Threonine Kinase, Bone Morphogenetic Protein Type IB; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. BMPR1b, also called Activin receptor-Like Kinase 6 (ALK6), functions as a receptor for bone morphogenetic proteins (BMPs), which are involved in the regulation of cell proliferation, survival, differentiation, and apoptosis. BMPs are able to induce bone, cartilage, ligament, and tendon formation, and may play roles in bone diseases and tumors. Mutations in BMPR1b that led to inhibition of chondrogenesis can cause Brachydactyly (BD) type A2, a dominant hand malformation characterized by shortening and lateral deviation of the index fingers. A point mutation in the BMPR1b kinase domain is also associated with the Booroola phenotype, characterized by precocious differentiation of ovarian follicles. BMPR1b belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like BMPR1b, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The BMPR1b subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271121 [Multi-domain]  Cd Length: 305  Bit Score: 61.22  E-value: 1.96e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVrvAIKKISPFEHQTYCQRTlrEIKILLRFRHENIIGI--NDIIRAPTIEQMkdvYIVQDLM 108
Cdd:cd14219  13 IGKGRYGEVWMGKWRGEKV--AVKVFFTTEEASWFRET--EIYQTVLMRHENILGFiaADIKGTGSWTQL---YLITDYH 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 109 ET-DLYKLLKTQHLSNDHICYFLYQILRGLKYIHS--------ANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHD 179
Cdd:cd14219  86 ENgSLYDYLKSTTLDTKAMLKLAYSSVSGLCHLHTeifstqgkPAIAHRDLKSKNILVKKNGTCCIADLGLAVKFISDTN 165
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 180 HTGF-LTEYVATRWYRAPEIM---LNSKGYTKSI--DIWSVGCILAEmLSNRPIFPGKHYLDQLNHILGILGSPSQEDLN 253
Cdd:cd14219 166 EVDIpPNTRVGTKRYMPPEVLdesLNRNHFQSYImaDMYSFGLILWE-VARRCVSGGIVEEYQLPYHDLVPSDPSYEDMR 244

                ....*.
gi 66932916 254 CIINLK 259
Cdd:cd14219 245 EIVCIK 250
STKc_nPKC_epsilon cd05591
Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze ...
128-330 2.02e-10

Catalytic domain of the Serine/Threonine Kinase, Novel Protein Kinase C epsilon; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-epsilon has been shown to behave as an oncoprotein. Its overexpression contributes to neoplastic transformation depending on the cell type. It contributes to oncogenesis by inducing disordered cell growth and inhibiting cell death. It also plays a role in tumor invasion and metastasis. PKC-epsilon has also been found to confer cardioprotection against ischemia and reperfusion-mediated damage. Other cellular functions include the regulation of gene expression, cell adhesion, and cell motility. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. nPKCs are calcium-independent, but require DAG (1,2-diacylglycerol) and phosphatidylserine (PS) for activity. The nPKC-epsilon subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270743 [Multi-domain]  Cd Length: 321  Bit Score: 61.35  E-value: 2.02e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 128 YFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgflTEYVATRWYRAPEImLNSKGYTK 207
Cdd:cd05591 100 FYAAEVTLALMFLHRHGVIYRDLKLDNILLDAEGHCKLADFGMCKEGILNGKTT---TTFCGTPDYIAPEI-LQELEYGP 175
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 208 SIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILgilgspsQEDLnciinlkarnyllslphknkvpwnrLFPNADSK-A 286
Cdd:cd05591 176 SVDWWALGVLMYEMMAGQPPFEADNEDDLFESIL-------HDDV-------------------------LYPVWLSKeA 223
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 287 LDLLDKMLTFNPHKRI------EVEQA-LAHPYLEQY-YDPSDEPIAEAPFK 330
Cdd:cd05591 224 VSILKAFMTKNPAKRLgcvasqGGEDAiRQHPFFREIdWEALEQRKVKPPFK 275
PTKc_FGFR2 cd05101
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs ...
131-230 2.21e-10

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. There are many splice variants of FGFR2 which show differential expression and binding to FGF ligands. Disruption of either FGFR2 or FGFR2b is lethal in mice, due to defects in the placenta or severe impairment of tissue development including lung, limb, and thyroid, respectively. Disruption of FGFR2c in mice results in defective bone and skull development. Genetic alterations of FGFR2 are associated with many human skeletal disorders including Apert syndrome, Crouzon syndrome, Jackson-Weiss syndrome, and Pfeiffer syndrome. FGFR2 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270679 [Multi-domain]  Cd Length: 313  Bit Score: 61.18  E-value: 2.21e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 131 YQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYrAPEIMLNsKGYTKSID 210
Cdd:cd05101 153 YQLARGMEYLASQKCIHRDLAARNVLVTENNVMKIADFGLARDINNIDYYKKTTNGRLPVKWM-APEALFD-RVYTHQSD 230
                        90       100
                ....*....|....*....|..
gi 66932916 211 IWSVGCILAEM--LSNRPiFPG 230
Cdd:cd05101 231 VWSFGVLMWEIftLGGSP-YPG 251
PTKc_DDR1 cd05096
Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; PTKs catalyze ...
31-223 2.31e-10

Catalytic domain of the Protein Tyrosine Kinase, Discoidin Domain Receptor 1; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. DDR1 is a receptor PTK (RTK) containing an extracellular discoidin homology domain, a transmembrane segment, an extended juxtamembrane region, and an intracellular catalytic domain. The binding of the ligand, collagen, to DDR1 results in a slow but sustained receptor activation. DDR1 binds to all collagens tested to date (types I-IV). It is widely expressed in many tissues. It is abundant in the brain and is also found in keratinocytes, colonic mucosa epithelium, lung epithelium, thyroid follicles, and the islets of Langerhans. During embryonic development, it is found in the developing neuroectoderm. DDR1 is a key regulator of cell morphogenesis, differentiation and proliferation. It is important in the development of the mammary gland, the vasculator and the kidney. DDR1 is also found in human leukocytes, where it facilitates cell adhesion, migration, maturation, and cytokine production. The DDR1 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 133227 [Multi-domain]  Cd Length: 304  Bit Score: 60.72  E-value: 2.31e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMV--CSAYD-----------NVNKVR---VAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRapt 94
Cdd:cd05096  13 LGEGQFGEVhlCEVVNpqdlptlqfpfNVRKGRpllVAVKILRPDANKNARNDFLKEVKILSRLKDPNIIRLLGVCV--- 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  95 ieQMKDVYIVQDLMET-DLYKLLKTQHL--------------------SNDHICYFLYQILRGLKYIHSANVLHRDLKPS 153
Cdd:cd05096  90 --DEDPLCMITEYMENgDLNQFLSSHHLddkeengndavppahclpaiSYSSLLHVALQIASGMKYLSSLNFVHRDLATR 167
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 66932916 154 NLLLNTTCDLKICDFGLAR--VADPDHDHTGflTEYVATRWYrAPEIMLNSKgYTKSIDIWSVGCILAEMLS 223
Cdd:cd05096 168 NCLVGENLTIKIADFGMSRnlYAGDYYRIQG--RAVLPIRWM-AWECILMGK-FTTASDVWAFGVTLWEILM 235
STKc_MLK3 cd14147
Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the ...
31-230 2.50e-10

Catalytic domain of the Serine/Threonine Kinase, Mixed Lineage Kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MLK3 is a mitogen-activated protein kinase kinase kinases (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. MLK3 activates multiple MAPK pathways and plays a role in apoptosis, proliferation, migration, and differentiation, depending on the cellular context. It is highly expressed in breast cancer cells and its signaling through c-Jun N-terminal kinase has been implicated in the migration, invasion, and malignancy of cancer cells. MLK3 also functions as a negative regulator of Inhibitor of Nuclear Factor-KappaB Kinase (IKK) and consequently, it also impacts inflammation and immunity. Mammals have four MLKs, mostly conserved in vertebrates, which contain an SH3 domain, a catalytic kinase domain, a leucine zipper, a proline-rich region, and a CRIB domain that mediates binding to GTP-bound Cdc42 and Rac. MLKs play roles in immunity and inflammation, as well as in cell death, proliferation, and cell cycle regulation.The MLK3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271049 [Multi-domain]  Cd Length: 267  Bit Score: 60.43  E-value: 2.50e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLR-EIKILLRFRHENIIGIndiiRAPTIEQMKDVYIVQDLME 109
Cdd:cd14147  11 IGIGGFGKVYRGSWRGELVAVKAARQDPDEDISVTAESVRqEARLFAMLAHPNIIAL----KAVCLEEPNLCLVMEYAAG 86
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 110 TDLYKLLKTQHLSNDHICYFLYQILRGLKYIHS---ANVLHRDLKPSNLLL--NTTCD------LKICDFGLARVAdpdH 178
Cdd:cd14147  87 GPLSRALAGRRVPPHVLVNWAVQIARGMHYLHCealVPVIHRDLKSNNILLlqPIENDdmehktLKITDFGLAREW---H 163
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 179 DHTGFLTeyVATRWYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIFPG 230
Cdd:cd14147 164 KTTQMSA--AGTYAWMAPEV-IKASTFSKGSDVWSFGVLLWELLTGEVPYRG 212
STKc_aPKC_zeta cd05617
Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze ...
112-228 2.66e-10

Catalytic domain of the Serine/Threonine Kinase, Atypical Protein Kinase C zeta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. PKC-zeta plays a critical role in activating the glucose transport response. It is activated by glucose, insulin, and exercise through diverse pathways. PKC-zeta also plays a central role in maintaining cell polarity in yeast and mammalian cells. In addition, it affects actin remodeling in muscle cells. PKCs are classified into three groups (classical, atypical, and novel) depending on their mode of activation and the structural characteristics of their regulatory domain. aPKCs only require phosphatidylserine (PS) for activation. The aPKC-zeta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270768 [Multi-domain]  Cd Length: 357  Bit Score: 61.19  E-value: 2.66e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 112 LYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTgflTEYVATR 191
Cdd:cd05617 104 MFHMQRQRKLPEEHARFYAAEICIALNFLHERGIIYRDLKLDNVLLDADGHIKLTDYGMCKEGLGPGDTT---STFCGTP 180
                        90       100       110
                ....*....|....*....|....*....|....*..
gi 66932916 192 WYRAPEImLNSKGYTKSIDIWSVGCILAEMLSNRPIF 228
Cdd:cd05617 181 NYIAPEI-LRGEEYGFSVDWWALGVLMFEMMAGRSPF 216
PTKc_Tie cd05047
Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the ...
31-223 2.82e-10

Catalytic domain of Tie Protein Tyrosine Kinases; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie proteins, consisting of Tie1 and Tie2, are receptor PTKs (RTKs) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. The angiopoietins (Ang-1 to Ang-4) serve as ligands for Tie2, while no specific ligand has been identified for Tie1. The binding of Ang-1 to Tie2 leads to receptor autophosphorylation and activation, promoting cell migration and survival. In contrast, Ang-2 binding to Tie2 does not result in the same response, suggesting that Ang-2 may function as an antagonist. In vivo studies of Tie1 show that it is critical in vascular development. The Tie subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270641 [Multi-domain]  Cd Length: 270  Bit Score: 60.44  E-value: 2.82e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAY--DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRF-RHENIIGIND-----------IIRAPTiE 96
Cdd:cd05047   3 IGEGNFGQVLKARikKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKLgHHPNIINLLGacehrgylylaIEYAPH-G 81
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  97 QMKDVYIVQDLMETDlyKLLKTQH-----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA 171
Cdd:cd05047  82 NLLDFLRKSRVLETD--PAFAIANstastLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARNILVGENYVAKIADFGLS 159
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 172 RVADPDHDHTgflTEYVATRWYRAPEimLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05047 160 RGQEVYVKKT---MGRLPVRWMAIES--LNYSVYTTNSDVWSYGVLLWEIVS 206
STKc_ACVR2a cd14141
Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor; STKs catalyze the ...
55-223 3.05e-10

Catalytic domain of the Serine/Threonine Kinase, Activin Type IIA Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2a (or ActRIIA) belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. ACVR2b is one of two ACVR2 receptors found in vertebrates. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. The ACVR2a subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271043 [Multi-domain]  Cd Length: 290  Bit Score: 60.44  E-value: 3.05e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  55 KISPFEHQTYCQRTLrEIKILLRFRHENIIG-INDIIRAPTIEQmkDVYIVQDLME-TDLYKLLKTQHLSNDHICYFLYQ 132
Cdd:cd14141  24 KIFPIQDKLSWQNEY-EIYSLPGMKHENILQfIGAEKRGTNLDV--DLWLITAFHEkGSLTDYLKANVVSWNELCHIAQT 100
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 133 ILRGLKYIHS----------ANVLHRDLKPSNLLLNTTCDLKICDFGLA------RVADPDHDHTGflteyvaTRWYRAP 196
Cdd:cd14141 101 MARGLAYLHEdipglkdghkPAIAHRDIKSKNVLLKNNLTACIADFGLAlkfeagKSAGDTHGQVG-------TRRYMAP 173
                       170       180       190
                ....*....|....*....|....*....|.
gi 66932916 197 EIMLNSKGYTKS----IDIWSVGCILAEMLS 223
Cdd:cd14141 174 EVLEGAINFQRDaflrIDMYAMGLVLWELAS 204
PTKc_EGFR cd05108
Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs ...
31-223 3.25e-10

Catalytic domain of the Protein Tyrosine Kinase, Epidermal Growth Factor Receptor; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. EGFR (HER1, ErbB1) is a receptor PTK (RTK) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands for EGFR include EGF, heparin binding EGF-like growth factor (HBEGF), epiregulin, amphiregulin, TGFalpha, and betacellulin. Upon ligand binding, EGFR can form homo- or heterodimers with other EGFR subfamily members. The EGFR signaling pathway is one of the most important pathways regulating cell proliferation, differentiation, survival, and growth. Overexpression and mutation in the kinase domain of EGFR have been implicated in the development and progression of a variety of cancers. A number of monoclonal antibodies and small molecule inhibitors have been developed that target EGFR, including the antibodies Cetuximab and Panitumumab, which are used in combination with other therapies for the treatment of colorectal cancer and non-small cell lung carcinoma (NSCLC). The small molecule inhibitors Gefitinib (Iressa) and Erlotinib (Tarceva), already used for NSCLC, are undergoing clinical trials for other types of cancer including gastrointestinal, breast, head and neck, and bladder. The EGFR subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270683 [Multi-domain]  Cd Length: 313  Bit Score: 60.42  E-value: 3.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVN----KVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQD 106
Cdd:cd05108  15 LGSGAFGTVYKGLWIPEgekvKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGC 94
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LMEtdlYKLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTE 186
Cdd:cd05108  95 LLD---YVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGG 171
                       170       180       190
                ....*....|....*....|....*....|....*..
gi 66932916 187 YVATRWYRAPEIMlnSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05108 172 KVPIKWMALESIL--HRIYTHQSDVWSYGVTVWELMT 206
PTKc_HER2 cd05109
Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the ...
132-223 3.32e-10

Catalytic domain of the Protein Tyrosine Kinase, HER2; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER2 (ErbB2, HER2/neu) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. HER2 does not bind to any known EGFR subfamily ligands, but contributes to the kinase activity of all possible heterodimers. It acts as the preferred partner of other ligand-bound EGFR proteins and functions as a signal amplifier, with the HER2-HER3 heterodimer being the most potent pair in mitogenic signaling. HER2 plays an important role in cell development, proliferation, survival and motility. Overexpression of HER2 results in its activation and downstream signaling, even in the absence of ligand. HER2 overexpression, mainly due to gene amplification, has been shown in a variety of human cancers. Its role in breast cancer is especially well-documented. HER2 is up-regulated in about 25% of breast tumors and is associated with increases in tumor aggressiveness, recurrence and mortality. HER2 is a target for monoclonal antibodies and small molecule inhibitors, which are being developed as treatments for cancer. The first humanized antibody approved for clinical use is Trastuzumab (Herceptin), which is being used in combination with other therapies to improve the survival rates of patients with HER2-overexpressing breast cancer. The HER2 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270684 [Multi-domain]  Cd Length: 279  Bit Score: 60.04  E-value: 3.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 132 QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHdhtgflTEY------VATRWYrAPEIMLNSKgY 205
Cdd:cd05109 117 QIAKGMSYLEEVRLVHRDLAARNVLVKSPNHVKITDFGLARLLDIDE------TEYhadggkVPIKWM-ALESILHRR-F 188
                        90
                ....*....|....*...
gi 66932916 206 TKSIDIWSVGCILAEMLS 223
Cdd:cd05109 189 THQSDVWSYGVTVWELMT 206
PTKc_FGFR3 cd05100
Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs ...
131-230 3.75e-10

Catalytic domain of the Protein Tyrosine Kinase, Fibroblast Growth Factor Receptor 3; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Many FGFR3 splice variants have been reported with the IIIb and IIIc isoforms being the predominant forms. FGFR3 IIIc is the isoform expressed in chondrocytes, the cells affected in dwarfism, while IIIb is expressed in epithelial cells. FGFR3 ligands include FGF1, FGF2, FGF4, FGF8, FGF9, and FGF23. It is a negative regulator of long bone growth. In the cochlear duct and in the lens, FGFR3 is involved in differentiation while it appears to have a role in cell proliferation in epithelial cells. Germline mutations in FGFR3 are associated with skeletal disorders including several forms of dwarfism. Some missense mutations are associated with multiple myeloma and carcinomas of the bladder and cervix. Overexpression of FGFR3 is found in thyroid carcinoma. FGFR3 is part of the FGFR subfamily, which are receptor PTKs (RTKs) containing an extracellular ligand-binding region with three immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. The binding of FGFRs to their ligands, the FGFs, results in receptor dimerization and activation, and intracellular signaling. The binding of FGFs to FGFRs is promiscuous, in that a receptor may be activated by several ligands and a ligand may bind to more that one type of receptor. The FGFR3 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173652 [Multi-domain]  Cd Length: 334  Bit Score: 60.42  E-value: 3.75e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 131 YQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR-VADPDHdHTGFLTEYVATRWYrAPEIMLNsKGYTKSI 209
Cdd:cd05100 141 YQVARGMEYLASQKCIHRDLAARNVLVTEDNVMKIADFGLARdVHNIDY-YKKTTNGRLPVKWM-APEALFD-RVYTHQS 217
                        90       100
                ....*....|....*....|..
gi 66932916 210 DIWSVGCILAEMLSNRPI-FPG 230
Cdd:cd05100 218 DVWSFGVLLWEIFTLGGSpYPG 239
STKc_Vps15 cd13980
Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein ...
25-228 3.98e-10

Catalytic domain of the Serine/Threonine kinase, Vacuolar protein sorting-associated protein 15; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. Vps15 is a large protein consisting of an N-terminal kinase domain, a C-terminal WD-repeat containing domain, and an intermediate bridge domain that contain HEAT repeats. The kinase domain is necessary for the signaling functions of Vps15. Human Vps15 was previously called p150. It associates and regulates Vps34, also called Class III phosphoinositide 3-kinase (PI3K), which catalyzes the phosphorylation of D-myo-phosphatidylinositol (PtdIns). Vps34 is the only PI3K present in yeast. It plays an important role in the regulation of protein and vesicular trafficking and sorting, autophagy, trimeric G-protein signaling, and phagocytosis. The Vps15 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and PI3K.


Pssm-ID: 270882 [Multi-domain]  Cd Length: 278  Bit Score: 59.96  E-value: 3.98e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  25 YTNLSYIGEGAYGMVCSAYDN--VNKVRVAIKKISPFEHQTYCQRtLREIKILLRfRHENIIGINDiirapTIEQMKDVY 102
Cdd:cd13980   2 YLYDKSLGSTRFLKVARARHDegLVVVKVFVKPDPALPLRSYKQR-LEEIRDRLL-ELPNVLPFQK-----VIETDKAAY 74
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 103 IVQDLMETDLYKLLKTQ-HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHT 181
Cdd:cd13980  75 LIRQYVKYNLYDRISTRpFLNLIEKKWIAFQLLHALNQCHKRGVCHGDIKTENVLVTSWNWVYLTDFASFKPTYLPEDNP 154
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 66932916 182 GFLTEYVAT----RWYRAPEIMLNSKGY-----------TKSIDIWSVGCILAEM-LSNRPIF 228
Cdd:cd13980 155 ADFSYFFDTsrrrTCYIAPERFVDALTLdaeserrdgelTPAMDIFSLGCVIAELfTEGRPLF 217
PK_GC cd13992
Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows ...
32-222 4.27e-10

Pseudokinase domain of membrane Guanylate Cyclase receptors; The pseudokinase domain shows similarity to protein kinases but lacks crucial residues for catalytic activity. Membrane (or particulate) GCs consist of an extracellular ligand-binding domain, a single transmembrane region, and an intracellular tail that contains a PK-like domain, an amphiphatic region and a catalytic GC domain that catalyzes the conversion of GTP into cGMP and pyrophosphate. Membrane GCs act as receptors that transduce an extracellular signal to the intracellular production of cGMP, which has been implicated in many processes including cell proliferation, phototransduction, and muscle contractility, through its downstream effectors such as PKG. The PK-like domain of GCs lack a critical aspartate involved in ATP binding and does not exhibit kinase activity. It functions as a negative regulator of the catalytic GC domain and may also act as a docking site for interacting proteins such as GC-activating proteins. The GC subfamily is part of a larger superfamily that includes the catalytic domains of protein serine/threonine kinases, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270894 [Multi-domain]  Cd Length: 268  Bit Score: 59.71  E-value: 4.27e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  32 GEGAYGMvcsaYDNVNKVR-VAIKKISPFEHQTycQRTLREIKILLRFRHENI---IGI----NDIIrapTIEQMKDVYI 103
Cdd:cd13992  12 GEPKYVK----KVGVYGGRtVAIKHITFSRTEK--RTILQELNQLKELVHDNLnkfIGIcinpPNIA---VVTEYCTRGS 82
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 104 VQDLMETDLYKLLKTQHLSndhicyFLYQILRGLKYIHSAN-VLHRDLKPSNLLLNTTCDLKICDFGLARvadPDHDHTG 182
Cdd:cd13992  83 LQDVLLNREIKMDWMFKSS------FIKDIVKGMNYLHSSSiGYHGRLKSSNCLVDSRWVVKLTDFGLRN---LLEEQTN 153
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 66932916 183 FLTEYVATR---WYRAPEIMLNSKGY---TKSIDIWSVGCILAEML 222
Cdd:cd13992 154 HQLDEDAQHkklLWTAPELLRGSLLEvrgTQKGDVYSFAIILYEIL 199
STKc_RIP1 cd14027
Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze ...
34-252 4.60e-10

Catalytic domain of the Serine/Threonine kinase, Receptor Interacting Protein 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. RIP1 harbors a C-terminal Death domain (DD), which binds death receptors (DRs) including TNF receptor 1, Fas, TNF-related apoptosis-inducing ligand receptor 1 (TRAILR1), and TRAILR2. It also interacts with other DD-containing adaptor proteins such as TRADD and FADD. RIP1 can also recruit other kinases including MEKK1, MEKK3, and RIP3 through an intermediate domain (ID) that bears a RIP homotypic interaction motif (RHIM). RIP1 plays a crucial role in determining a cell's fate, between survival or death, following exposure to stress signals. It is important in the signaling of NF-kappaB and MAPKs, and it links DR-associated signaling to reactive oxygen species (ROS) production. Abnormal RIP1 function may result in ROS accummulation affecting inflammatory responses, innate immunity, stress responses, and cell survival. RIP kinases serve as essential sensors of cellular stress. The RIP1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270929 [Multi-domain]  Cd Length: 267  Bit Score: 59.44  E-value: 4.60e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  34 GAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIraptIEQMKDVYIVQDLMETDLY 113
Cdd:cd14027   4 GGFGKVSLCFHRTQGLVVLKTVYTGPNCIEHNEALLEEGKMMNRLRHSRVVKLLGVI----LEEGKYSLVMEYMEKGNLM 79
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 114 KLLKTQHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA------RVADPDH----DHTGF 183
Cdd:cd14027  80 HVLKKVSVPLSVKGRIILEIIEGMAYLHGKGVIHKDLKPENILVDNDFHIKIADLGLAsfkmwsKLTKEEHneqrEVDGT 159
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 66932916 184 LTEYVATRWYRAPEIM--LNSKGYTKSiDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDL 252
Cdd:cd14027 160 AKKNAGTLYYMAPEHLndVNAKPTEKS-DVYSFAIVLWAIFANKEPYENAINEDQIIMCIKSGNRPDVDDI 229
STKc_B-Raf cd14151
Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) ...
12-242 4.97e-10

Catalytic domain of the Serine/Threonine Kinase, B-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. B-Raf activates ERK with the strongest magnitude, compared with other Raf kinases. Mice embryos deficient in B-Raf die around midgestation due to vascular hemorrhage caused by apoptotic endothelial cells. Mutations in B-Raf have been implicated in initiating tumorigenesis and tumor progression, and are found in malignant cutaneous melanoma, papillary thyroid cancer, as well as in ovarian and colorectal carcinomas. Most oncogenic B-Raf mutations are located at the activation loop of the kinase and surrounding regions; the V600E mutation accounts for around 90% of oncogenic mutations. The V600E mutant constitutively activates MEK, resulting in sustained activation of ERK. B-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. They function in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The B-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271053 [Multi-domain]  Cd Length: 274  Bit Score: 59.69  E-value: 4.97e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  12 EMVRGQVfDVGPRytnlsyIGEGAYGMVcsaYDNVNKVRVAIKKI---SPFEHQTycQRTLREIKILLRFRHENIIGIND 88
Cdd:cd14151   4 EIPDGQI-TVGQR------IGSGSFGTV---YKGKWHGDVAVKMLnvtAPTPQQL--QAFKNEVGVLRKTRHVNILLFMG 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  89 IIRAPTIeqmkdVYIVQDLMETDLYKLLKTQHLSNDHICYF--LYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKIC 166
Cdd:cd14151  72 YSTKPQL-----AIVTQWCEGSSLYHHLHIIETKFEMIKLIdiARQTAQGMDYLHAKSIIHRDLKSNNIFLHEDLTVKIG 146
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 66932916 167 DFGLARVADPDHDHTGFLTEYVATRWYrAPEI--MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 242
Cdd:cd14151 147 DFGLATVKSRWSGSHQFEQLSGSILWM-APEVirMQDKNPYSFQSDVYAFGIVLYELMTGQLPYSNINNRDQIIFMVG 223
STKc_KIS cd14020
Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called ...
119-313 5.11e-10

Catalytic domain of the Serine/Threonine Kinase, Kinase Interacting with Stathmin (also called U2AF homology motif (UHM) kinase 1); STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. KIS (or UHMK1) contains an N-terminal kinase domain and a C-terminal domain with a UHM motif, a protein interaction motif initially found in the pre-mRNA splicing factor U2AF. It phosphorylates the splicing factor SF1, which enhances binding to the splice site to promote spliceosome assembly. KIS was first identified as a kinase that interacts with stathmin, a phosphoprotein that plays a role in axon development and microtubule dynamics. It localizes in RNA granules in neurons and is important in neurite outgrowth. The KIS/UHMK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270922 [Multi-domain]  Cd Length: 285  Bit Score: 59.56  E-value: 5.11e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 119 QHLSNDhicyflyqILRGLKYIHSANVLHRDLKPSNLLLNTTCD-LKICDFGLArVADPDHDhtgflTEYVATRWYRAPE 197
Cdd:cd14020 113 QHCARD--------VLEALAFLHHEGYVHADLKPRNILWSAEDEcFKLIDFGLS-FKEGNQD-----VKYIQTDGYRAPE 178
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 198 IMLNS----------KGYTKSIDIWSVGCILAEMLSNRpifpgkhyldQLNHILgilgsPSQE---DLNCIIN-LKARNY 263
Cdd:cd14020 179 AELQNclaqaglqseTECTSAVDLWSLGIVLLEMFSGM----------KLKHTV-----RSQEwkdNSSAIIDhIFASNA 243
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 264 LLSlphkNKVPWNRLfpnadskaLDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14020 244 VVN----PAIPAYHL--------RDLIKSMLHNDPGKRATAEAALCSPFF 281
STKc_MRCK_beta cd05624
Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control ...
28-222 6.01e-10

Catalytic domain of the Protein Serine/Threonine Kinase, DMPK-related cell division control protein 42 binding kinase (MRCK) beta; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. MRCK-beta is expressed ubiquitously in many tissues. MRCK is activated via interaction with the small GTPase Cdc42. MRCK/Cdc42 signaling mediates myosin-dependent cell motility. The MRCK-beta subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. This alignment model includes the dimerization domain.


Pssm-ID: 270774 [Multi-domain]  Cd Length: 409  Bit Score: 60.02  E-value: 6.01e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGmvcsaydnvnkvRVAIKKISPFEhQTYCQRTLREIKILLR-----FRHENIIGINDIIRAPT-----IEQ 97
Cdd:cd05624  77 IKVIGRGAFG------------EVAVVKMKNTE-RIYAMKILNKWEMLKRaetacFREERNVLVNGDCQWITtlhyaFQD 143
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  98 MKDVYIVQDL-METDLYKLLKT--QHLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGlaRVA 174
Cdd:cd05624 144 ENYLYLVMDYyVGGDLLTLLSKfeDKLPEDMARFYIGEMVLAIHSIHQLHYVHRDIKPDNVLLDMNGHIRLADFG--SCL 221
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 175 DPDHDHTGFLTEYVATRWYRAPEI---MLNSKG-YTKSIDIWSVGCILAEML 222
Cdd:cd05624 222 KMNDDGTVQSSVAVGTPDYISPEIlqaMEDGMGkYGPECDWWSLGVCMYEML 273
PTKc_TrkA cd05092
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze ...
31-223 6.96e-10

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase A; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkA is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkA to its ligand, nerve growth factor (NGF), results in receptor oligomerization and activation of the catalytic domain. TrkA is expressed mainly in neural-crest-derived sensory and sympathetic neurons of the peripheral nervous system, and in basal forebrain cholinergic neurons of the central nervous system. It is critical for neuronal growth, differentiation and survival. Alternative TrkA splicing has been implicated as a pivotal regulator of neuroblastoma (NB) behavior. Normal TrkA expression is associated with better NB prognosis, while the hypoxia-regulated TrkAIII splice variant promotes NB pathogenesis and progression. Aberrant TrkA expression has also been demonstrated in non-neural tumors including prostate, breast, lung, and pancreatic cancers. The TrkA subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270674 [Multi-domain]  Cd Length: 280  Bit Score: 59.21  E-value: 6.96e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSA-----YDNVNKVRVAIKKISPFEHQTYcQRTLREIKILLRFRHENIIGINDIirapTIEQMKDVYIVQ 105
Cdd:cd05092  13 LGEGAFGKVFLAechnlLPEQDKMLVAVKALKEATESAR-QDFQREAELLTVLQHQHIVRFYGV----CTEGEPLIMVFE 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETDLYKLLKTQ----------------HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFG 169
Cdd:cd05092  88 YMRHGDLNRFLRSHgpdakildggegqapgQLTLGQMLQIASQIASGMVYLASLHFVHRDLATRNCLVGQGLVVKIGDFG 167
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 170 LAR-VADPDHDHTGFLTeYVATRWYrAPEIMLNSKGYTKSiDIWSVGCILAEMLS 223
Cdd:cd05092 168 MSRdIYSTDYYRVGGRT-MLPIRWM-PPESILYRKFTTES-DIWSFGVVLWEIFT 219
PTKc_HER4 cd05110
Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the ...
31-233 8.52e-10

Catalytic domain of the Protein Tyrosine Kinase, HER4; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. HER4 (ErbB4) is a member of the EGFR (HER, ErbB) subfamily of proteins, which are receptor PTKs (RTKs) containing an extracellular EGF-related ligand-binding region, a transmembrane helix, and a cytoplasmic region with a tyr kinase domain and a regulatory C-terminal tail. Unlike other PTKs, phosphorylation of the activation loop of EGFR proteins is not critical to their activation. Instead, they are activated by ligand-induced dimerization, leading to the phosphorylation of tyr residues in the C-terminal tail, which serve as binding sites for downstream signaling molecules. Ligands that bind HER4 fall into two groups, the neuregulins (or heregulins) and some EGFR (HER1) ligands including betacellulin, HBEGF, and epiregulin. All four neuregulins (NRG1-4) interact with HER4. Upon ligand binding, HER4 forms homo- or heterodimers with other HER proteins. HER4 is essential in embryonic development. It is implicated in mammary gland, cardiac, and neural development. As a postsynaptic receptor of NRG1, HER4 plays an important role in synaptic plasticity and maturation. The impairment of NRG1/HER4 signaling may contribute to schizophrenia. The HER4 subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173655 [Multi-domain]  Cd Length: 303  Bit Score: 59.31  E-value: 8.52e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAY----DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEqmkdvyIVQD 106
Cdd:cd05110  15 LGSGAFGTVYKGIwvpeGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDHPHLVRLLGVCLSPTIQ------LVTQ 88
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 107 LMETDLykLLKTQHLSNDHICYFLY-----QILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHT 181
Cdd:cd05110  89 LMPHGC--LLDYVHEHKDNIGSQLLlnwcvQIAKGMMYLEERRLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEY 166
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 66932916 182 GFLTEYVATRWYRAPEImlNSKGYTKSIDIWSVGCILAEMLSnrpiFPGKHY 233
Cdd:cd05110 167 NADGGKMPIKWMALECI--HYRKFTHQSDVWSYGVTIWELMT----FGGKPY 212
STKc_ACVR1_ALK1 cd14142
Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin ...
31-221 1.06e-09

Catalytic domain of the Serine/Threonine Kinases, Activin Type I Receptor and Activin receptor-Like Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR1, also called Activin receptor-Like Kinase 2 (ALK2), and ALK1 act as receptors for bone morphogenetic proteins (BMPs) and they activate SMAD1/5/8. ACVR1 is widely expressed while ALK1 is limited mainly to endothelial cells. The specificity of BMP binding to type I receptors is affected by type II receptors. ACVR1 binds BMP6/7/9/10 and can also bind anti-Mullerian hormone (AMH) in the presence of AMHR2. ALK1 binds BMP9/10 as well as TGFbeta in endothelial cells. A missense mutation in the GS domain of ACVR1 causes fibrodysplasia ossificans progressiva, a complex and disabling disease characterized by congenital skeletal malformations and extraskeletal bone formation. ACVR1 belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, BMPs, activins, growth and differentiation factors, and AMH, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane (TM) region, and a cytoplasmic catalytic kinase domain. Type I receptors, like ACVR1 and ALK1, are low-affinity receptors that bind ligands only after they are recruited by the ligand/type II high-affinity receptor complex. Following activation, they start intracellular signaling to the nucleus by phosphorylating SMAD proteins. Type I receptors contain an additional domain located between the TM and kinase domains called the GS domain, which contains the activating phosphorylation site and confers preference for specific SMAD proteins. The ACVR1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271044 [Multi-domain]  Cd Length: 298  Bit Score: 58.99  E-value: 1.06e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMV-CSAYDNVNkvrVAIKKISPFEHQTYCQRTlrEIKILLRFRHENIIGI--NDIIRAPTIEQMkdvYIVQDL 107
Cdd:cd14142  13 IGKGRYGEVwRGQWQGES---VAVKIFSSRDEKSWFRET--EIYNTVLLRHENILGFiaSDMTSRNSCTQL---WLITHY 84
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 MET-DLYKLLKTQHLSNDHICYFLYQILRGLKYIHS--------ANVLHRDLKPSNLLL--NTTCdlKICDFGLA----- 171
Cdd:cd14142  85 HENgSLYDYLQRTTLDHQEMLRLALSAASGLVHLHTeifgtqgkPAIAHRDLKSKNILVksNGQC--CIADLGLAvthsq 162
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 172 --RVADPDHDHTgflteyVATRWYRAPEIMLNSKGYT-----KSIDIWSVGCILAEM 221
Cdd:cd14142 163 etNQLDVGNNPR------VGTKRYMAPEVLDETINTDcfesyKRVDIYAFGLVLWEV 213
STKc_PIM3 cd14102
Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) ...
129-222 1.07e-09

Catalytic domain of the Serine/Threonine kinase, Proviral Integration Moloney virus (PIM) kinase 3; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. The PIM gene locus was discovered as a result of the cloning of retroviral intergration sites in murine Moloney leukemia virus, leading to the identification of PIM kinases. They are constitutively active STKs with a broad range of cellular targets and are overexpressed in many haematopoietic malignancies and solid cancers. Vertebrates contain three distinct PIM kinase genes (PIM1-3). PIM3 can inhibit apoptosis and promote cell survival and protein translation, therefore, it can enhance the proliferation of normal and cancer cells. Mice deficient with PIM3 show minimal effects, suggesting that PIM3 msy not be essential. Since its expression is enhanced in several cancers, it may make a good molecular target for cancer drugs. The PIM3 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271004 [Multi-domain]  Cd Length: 253  Bit Score: 58.43  E-value: 1.07e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 129 FLYQILRGLKYIHSANVLHRDLKPSNLLLNT-TCDLKICDFGL-ARVADPDHdhtgflTEYVATRWYRAPEIMLNSKGYT 206
Cdd:cd14102 110 FFRQVLEAVRHCYSCGVVHRDIKDENLLVDLrTGELKLIDFGSgALLKDTVY------TDFDGTRVYSPPEWIRYHRYHG 183
                        90
                ....*....|....*.
gi 66932916 207 KSIDIWSVGCILAEML 222
Cdd:cd14102 184 RSATVWSLGVLLYDMV 199
PTKc_RET cd05045
Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs ...
129-230 1.48e-09

Catalytic domain of the Protein Tyrosine Kinase, REarranged during Transfection protein; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. RET is a receptor PTK (RTK) containing an extracellular region with four cadherin-like repeats, a calcium-binding site, and a cysteine-rich domain, a transmembrane segment, and an intracellular catalytic domain. It is part of a multisubunit complex that binds glial-derived neurotropic factor (GDNF) family ligands (GFLs) including GDNF, neurturin, artemin, and persephin. GFLs bind RET along with four GPI-anchored coreceptors, bringing two RET molecules together, leading to autophosphorylation, activation, and intracellular signaling. RET is essential for the development of the sympathetic, parasympathetic and enteric nervous systems, and the kidney. RET disruption by germline mutations causes diseases in humans including congenital aganglionosis of the gastrointestinal tract (Hirschsprung's disease) and three related inherited cancers: multiple endocrine neoplasia type 2A (MEN2A), MEN2B, and familial medullary thyroid carcinoma. The RET subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 173631 [Multi-domain]  Cd Length: 290  Bit Score: 58.44  E-value: 1.48e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 129 FLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDHTGFLTEYVATRWYrAPEIMLNSKgYTKS 208
Cdd:cd05045 132 FAWQISRGMQYLAEMKLVHRDLAARNVLVAEGRKMKISDFGLSRDVYEEDSYVKRSKGRIPVKWM-AIESLFDHI-YTTQ 209
                        90       100
                ....*....|....*....|....
gi 66932916 209 IDIWSVGCILAEM--LSNRPiFPG 230
Cdd:cd05045 210 SDVWSFGVLLWEIvtLGGNP-YPG 232
STKc_WNK1 cd14030
Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze ...
31-224 1.51e-09

Catalytic domain of the Serine/Threonine protein kinase, With No Lysine (WNK) 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. WNK1 is widely expressed and is most abundant in the testis. In hyperosmotic or hypotonic low-chloride stress conditions, WNK1 is activated and it phosphorylates its substrates including SPAK and OSR1 kinases, which regulate the activity of cation-chloride cotransporters through direct interaction and phosphorylation. Mutations in WNK1 cause PseudoHypoAldosteronism type II (PHAII), characterized by hypertension and hyperkalemia. WNK1 negates WNK4-mediated inhibition of the sodium-chloride cotransporter NCC and activates the epithelial sodium channel ENaC by activating SGK1. WNK1 also decreases the surface expression of renal outer medullary potassium channel (ROMK) by stimulating their endocytosis. Hypertension and hyperkalemia in PHAII patients with WNK1 mutations may be due partly to increased activity of NCC and ENaC, and impaired renal potassium secretion by ROMK, respectively. In addition, WNK1 interacts with MEKK2/3 and acts as an activator of extracellular signal-regulated kinase (ERK) 5. It also negatively regulates TGFbeta signaling. WNKs comprise a subfamily of STKs with an unusual placement of the catalytic lysine relative to all other protein kinases. The WNK1 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270932 [Multi-domain]  Cd Length: 289  Bit Score: 58.14  E-value: 1.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNVNKVRVAI-----KKISPFEHQtycqRTLREIKILLRFRHENIIGINDIIRAPtIEQMKDVYIVQ 105
Cdd:cd14030  33 IGRGSFKTVYKGLDTETTVEVAWcelqdRKLSKSERQ----RFKEEAGMLKGLQHPNIVRFYDSWEST-VKGKKCIVLVT 107
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETDL-------YKLLKTQHLSNdhicyFLYQILRGLKYIHSAN--VLHRDLKPSNLLLN-TTCDLKICDFGLARVad 175
Cdd:cd14030 108 ELMTSGTlktylkrFKVMKIKVLRS-----WCRQILKGLQFLHTRTppIIHRDLKCDNIFITgPTGSVKIGDLGLATL-- 180
                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 66932916 176 pdhDHTGFLTEYVATRWYRAPEIMlnSKGYTKSIDIWSVGCILAEMLSN 224
Cdd:cd14030 181 ---KRASFAKSVIGTPEFMAPEMY--EEKYDESVDVYAFGMCMLEMATS 224
PKc_TNNI3K cd14064
Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; ...
31-223 1.54e-09

Catalytic domain of the Dual-specificity protein kinase, TNNI3-interacting kinase; Dual-specificity PKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine as well as tyrosine residues on protein substrates. TNNI3K, also called cardiac ankyrin repeat kinase (CARK), is a cardiac-specific troponin I-interacting kinase that promotes cardiac myogenesis, improves cardiac performance, and protects the myocardium from ischemic injury. It contains N-terminal ankyrin repeats, a catalytic kinase domain, and a C-terminal serine-rich domain. TNNI3K exerts a disease-accelerating effect on cardiac dysfunction and reduced survival in mouse models of cardiomyopathy. The TNNI3K subfamily is part of a larger superfamily that includes the catalytic domains of other protein serine/threonine PKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270966 [Multi-domain]  Cd Length: 254  Bit Score: 57.92  E-value: 1.54e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAYDNvNKVrVAIKKispFEHQTYCQRT-----LREIKILLRFRHENIIGIndiiRAPTIEQMKDVYIVQ 105
Cdd:cd14064   1 IGSGSFGKVYKGRCR-NKI-VAIKR---YRANTYCSKSdvdmfCREVSILCRLNHPCVIQF----VGACLDDPSQFAIVT 71
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMET-DLYKLLKTQHLSNDHICYFLYQI--LRGLKYIHSAN--VLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH 180
Cdd:cd14064  72 QYVSGgSLFSLLHEQKRVIDLQSKLIIAVdvAKGMEYLHNLTqpIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDED 151
                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 66932916 181 TgfLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd14064 152 N--MTKQPGNLRWMAPEVFTQCTRYSIKADVFSYALCLWELLT 192
PTKc_Tie1 cd05089
Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; ...
31-223 2.31e-09

Catalytic domain of the Protein Tyrosine Kinase, Tie1; Protein Tyrosine Kinase (PTK) family; Tie1; catalytic (c) domain. The PTKc family is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, and phosphoinositide 3-kinase (PI3K). PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. Tie1 is a receptor tyr kinase (RTK) containing an extracellular region, a transmembrane segment, and an intracellular catalytic domain. The extracellular region contains an immunoglobulin (Ig)-like domain, three epidermal growth factor (EGF)-like domains, a second Ig-like domain, and three fibronectin type III repeats. Tie receptors are specifically expressed in endothelial cells and hematopoietic stem cells. No specific ligand has been identified for Tie1, although the angiopoietin, Ang-1, binds to Tie1 through integrins at high concentrations. In vivo studies of Tie1 show that it is critical in vascular development.


Pssm-ID: 270671 [Multi-domain]  Cd Length: 297  Bit Score: 57.70  E-value: 2.31e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSAY--DNVNKVRVAIKKISPFEHQTYCQRTLREIKILLRF-RHENIIGI-----NDIIRAPTIE-----Q 97
Cdd:cd05089  10 IGEGNFGQVIKAMikKDGLKMNAAIKMLKEFASENDHRDFAGELEVLCKLgHHPNIINLlgaceNRGYLYIAIEyapygN 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  98 MKDVYIVQDLMETDlyKLLKTQH-----LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLAR 172
Cdd:cd05089  90 LLDFLRKSRVLETD--PAFAKEHgtastLTSQQLLQFASDVAKGMQYLSEKQFIHRDLAARNVLVGENLVSKIADFGLSR 167
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|.
gi 66932916 173 VADPDHDHTgflTEYVATRWYRAPEimLNSKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05089 168 GEEVYVKKT---MGRLPVRWMAIES--LNYSVYTTKSDVWSFGVLLWEIVS 213
PTKc_TrkB cd05093
Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze ...
31-223 2.36e-09

Catalytic domain of the Protein Tyrosine Kinase, Tropomyosin Related Kinase B; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. TrkB is a receptor PTK (RTK) containing an extracellular region with arrays of leucine-rich motifs flanked by two cysteine-rich clusters followed by two immunoglobulin-like domains, a transmembrane segment, and an intracellular catalytic domain. Binding of TrkB to its ligands, brain-derived neurotrophic factor (BDNF) or neurotrophin 4 (NT4), results in receptor oligomerization and activation of the catalytic domain. TrkB is broadly expressed in the nervous system and in some non-neural tissues. It plays important roles in cell proliferation, differentiation, and survival. BDNF/Trk signaling plays a key role in regulating activity-dependent synaptic plasticity. TrkB also contributes to protection against gp120-induced neuronal cell death. TrkB overexpression is associated with poor prognosis in neuroblastoma (NB) and other human cancers. It acts as a suppressor of anoikis (detachment-induced apoptosis) and contributes to tumor metastasis. The TrkB subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270675 [Multi-domain]  Cd Length: 288  Bit Score: 57.74  E-value: 2.36e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMVCSA--YD---NVNKVRVAIKKISPFEHQTYcQRTLREIKILLRFRHENIIGINDIirapTIEQMKDVYIVQ 105
Cdd:cd05093  13 LGEGAFGKVFLAecYNlcpEQDKILVAVKTLKDASDNAR-KDFHREAELLTNLQHEHIVKFYGV----CVEGDPLIMVFE 87
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 106 DLMETDLYKLLKTQ--------------HLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLA 171
Cdd:cd05093  88 YMKHGDLNKFLRAHgpdavlmaegnrpaELTQSQMLHIAQQIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMS 167
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 66932916 172 R-VADPDHDHTGFLTeYVATRWYRAPEIMLnsKGYTKSIDIWSVGCILAEMLS 223
Cdd:cd05093 168 RdVYSTDYYRVGGHT-MLPIRWMPPESIMY--RKFTTESDVWSLGVVLWEIFT 217
STKc_C-Raf cd14149
Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) ...
28-242 2.92e-09

Catalytic domain of the Serine/Threonine Kinase, C-Raf (Rapidly Accelerated Fibrosarcoma) kinase; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. C-Raf, also known as Raf-1 or c-Raf-1, is ubiquitously expressed and was the first Raf identified. It was characterized as the acquired oncogene from an acutely transforming murine sarcoma virus (3611-MSV) and the transforming agent from the avian retrovirus MH2. C-Raf-deficient mice embryos die around midgestation with increased apoptosis of embryonic tissues, especially in the fetal liver. One of the main functions of C-Raf is restricting caspase activation to promote survival in response to specific stimuli such as Fas stimulation, macrophage apoptosis, and erythroid differentiation. C-Raf is a mitogen-activated protein kinase kinase kinase (MAP3K, MKKK, MAPKKK), which phosphorylates and activates MAPK kinases (MAPKKs or MKKs or MAP2Ks), which in turn phosphorylate and activate MAPKs during signaling cascades that are important in mediating cellular responses to extracellular signals. It functions in the linear Ras-Raf-MEK-ERK pathway that regulates many cellular processes including cycle regulation, proliferation, differentiation, survival, and apoptosis. The C-Raf subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271051 [Multi-domain]  Cd Length: 283  Bit Score: 57.35  E-value: 2.92e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  28 LSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFEHQTYCQRTlrEIKILLRFRHENIIGINDIIRAPTIeqmkdVYIVQDL 107
Cdd:cd14149  17 STRIGSGSFGTVYKGKWHGDVAVKILKVVDPTPEQFQAFRN--EVAVLRKTRHVNILLFMGYMTKDNL-----AIVTQWC 89
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 108 METDLYKLLKTQHLSND--HICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVaDPDHDHTGFLT 185
Cdd:cd14149  90 EGSSLYKHLHVQETKFQmfQLIDIARQTAQGMDYLHAKNIIHRDMKSNNIFLHEGLTVKIGDFGLATV-KSRWSGSQQVE 168
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 66932916 186 EYVATRWYRAPEI--MLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILG 242
Cdd:cd14149 169 QPTGSILWMAPEVirMQDNNPFSFQSDVYSYGIVLYELMTGELPYSHINNRDQIIFMVG 227
STKc_LRRK1 cd14067
Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze ...
131-258 3.18e-09

Catalytic domain of the Serine/Threonine Kinase, Leucine-Rich Repeat Kinase 1; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. LRRK1 is one of two vertebrate LRRKs which show complementary expression in the brain. It can form heterodimers with LRRK2, and may influence the age of onset of LRRK2-associated Parkinson's disease. LRRKs are also classified as ROCO proteins because they contain a ROC (Ras of complex proteins)/GTPase domain followed by a COR (C-terminal of ROC) domain of unknown function. In addition, LRRKs contain a catalytic kinase domain and protein-protein interaction motifs including a WD40 domain, LRRs and ankyrin (ANK) repeats. LRRKs possess both GTPase and kinase activities, with the ROC domain acting as a molecular switch for the kinase domain, cycling between a GTP-bound state which drives kinase activity and a GDP-bound state which decreases the activity. The LRRK1 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270969 [Multi-domain]  Cd Length: 276  Bit Score: 57.28  E-value: 3.18e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 131 YQILRGLKYIHSANVLHRDLKPSNLLL-----NTTCDLKICDFGLARVAdpdhDHTGFLTeYVATRWYRAPEIMLNSKgY 205
Cdd:cd14067 121 YQIAAGLAYLHKKNIIFCDLKSDNILVwsldvQEHINIKLSDYGISRQS----FHEGALG-VEGTPGYQAPEIRPRIV-Y 194
                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 66932916 206 TKSIDIWSVGCILAEMLSNRPIFPGKHYLD---QLNH-ILGILGSPSQEDLNCIINL 258
Cdd:cd14067 195 DEKVDMFSYGMVLYELLSGQRPSLGHHQLQiakKLSKgIRPVLGQPEEVQFFRLQAL 251
STKc_ACVR2b cd14140
Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor; STKs catalyze the ...
51-261 4.66e-09

Catalytic domain of the Serine/Threonine Kinase, Activin Type IIB Receptor; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. ACVR2b (or ActRIIB) belongs to a group of receptors for the TGFbeta family of secreted signaling molecules that includes TGFbeta, bone morphogenetic proteins (BMPs), activins, growth and differentiation factors (GDFs), and anti-Mullerian hormone, among others. These receptors contain an extracellular domain that binds ligands, a single transmembrane region, and a cytoplasmic catalytic kinase domain. ACVR2b is one of two ACVR2 receptors found in vertebrates. Type II receptors are high-affinity receptors which bind ligands, autophosphorylate, as well as trans-phosphorylate and activate low-affinity type I receptors. ACVR2 acts primarily as the receptors for activins, nodal, myostatin, GDF11, and a subset of BMPs. ACVR2 signaling impacts many cellular and physiological processes including reproductive and gonadal functions, myogenesis, bone remodeling and tooth development, kidney organogenesis, apoptosis, fibrosis, inflammation, and neurogenesis. The ACVR2b subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 271042 [Multi-domain]  Cd Length: 291  Bit Score: 56.96  E-value: 4.66e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  51 VAIKkISPFEHQTYCQRTlREIKILLRFRHENIIG-INDIIRAPTIEQmkDVYIVQDLMET-DLYKLLKTQHLSNDHICY 128
Cdd:cd14140  21 VAVK-IFPIQDKQSWQSE-REIFSTPGMKHENLLQfIAAEKRGSNLEM--ELWLITAFHDKgSLTDYLKGNIVSWNELCH 96
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 129 FLYQILRGLKYIHS-----------ANVLHRDLKPSNLLLNTTCDLKICDFGLA---RVADPDHDHTGflteYVATRWYR 194
Cdd:cd14140  97 IAETMARGLSYLHEdvprckgeghkPAIAHRDFKSKNVLLKNDLTAVLADFGLAvrfEPGKPPGDTHG----QVGTRRYM 172
                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 66932916 195 APEIMLNSKGYTKS----IDIWSVGCILAEMLSNRPIF--PGKHYLDQLNHILGilGSPSQEDL-NCIINLKAR 261
Cdd:cd14140 173 APEVLEGAINFQRDsflrIDMYAMGLVLWELVSRCKAAdgPVDEYMLPFEEEIG--QHPSLEDLqEVVVHKKMR 244
PTKc_Ror cd05048
Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan ...
31-223 5.51e-09

Catalytic Domain of the Protein Tyrosine Kinases, Receptor tyrosine kinase-like Orphan Receptors; PTKs catalyze the transfer of the gamma-phosphoryl group from ATP to tyrosine (tyr) residues in protein substrates. The Ror subfamily consists of Ror1, Ror2, and similar proteins. Ror proteins are orphan receptor PTKs (RTKs) containing an extracellular region with immunoglobulin-like, cysteine-rich, and kringle domains, a transmembrane segment, and an intracellular catalytic domain. Ror RTKs are unrelated to the nuclear receptor subfamily called retinoid-related orphan receptors (RORs). RTKs are usually activated through ligand binding, which causes dimerization and autophosphorylation of the intracellular tyr kinase catalytic domain. Ror kinases are expressed in many tissues during development. They play important roles in bone and heart formation. Mutations in human Ror2 result in two different bone development genetic disorders, recessive Robinow syndrome and brachydactyly type B. Drosophila Ror is expressed only in the developing nervous system during neurite outgrowth and neuronal differentiation, suggesting a role for Drosophila Ror in neural development. More recently, mouse Ror1 and Ror2 have also been found to play an important role in regulating neurite growth in central neurons. Ror1 and Ror2 are believed to have some overlapping and redundant functions. The Ror subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as protein serine/threonine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270642 [Multi-domain]  Cd Length: 283  Bit Score: 56.61  E-value: 5.51e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  31 IGEGAYGMV-----CSAYDNVNKVRVAIKKI----SPFEHQTYcqrtLREIKILLRFRHENIIginDIIRAPTIEQ---M 98
Cdd:cd05048  13 LGEGAFGKVykgelLGPSSEESAISVAIKTLkenaSPKTQQDF----RREAELMSDLQHPNIV---CLLGVCTKEQpqcM 85
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916  99 KDVYIVQ-DLMEtdlYKLLKTQH---------------LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCD 162
Cdd:cd05048  86 LFEYMAHgDLHE---FLVRHSPHsdvgvssdddgtassLDQSDFLHIAIQIAAGMEYLSSHHYVHRDLAARNCLVGDGLT 162
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 66932916 163 LKICDFGLARvadpD---HDHTGFLTEYV-ATRWYrAPEIMLNSKgYTKSIDIWSVGCILAEMLS 223
Cdd:cd05048 163 VKISDFGLSR----DiysSDYYRVQSKSLlPVRWM-PPEAILYGK-FTTESDVWSFGVVLWEIFS 221
STKc_SNT7_plant cd14013
Catalytic domain of the Serine/Threonine kinase, Plant SNT7; STKs catalyze the transfer of the ...
132-313 5.61e-09

Catalytic domain of the Serine/Threonine kinase, Plant SNT7; STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. SNT7 is a plant thylakoid-associated kinase that is essential in short- and long-term acclimation responses to cope with various light conditions in order to maintain photosynthetic redox poise for optimal photosynthetic performance. Short-term response involves state transitions over periods of minutes while the long-term response (LTR) occurs over hours to days and involves changing the relative amounts of photosystems I and II. SNT7 acts as a redox sensor and a signal transducer for both responses, which are triggered by the redox state of the plastoquinone (PQ) pool. It is positioned at the top of a phosphorylation cascade that induces state transitions by phosphorylating light-harvesting complex II (LHCII), and triggers the LTR through the phosphorylation of chloroplast proteins. The SNT7 subfamily is part of a larger superfamily that includes the catalytic domains of other protein STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase.


Pssm-ID: 270915 [Multi-domain]  Cd Length: 318  Bit Score: 56.68  E-value: 5.61e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 132 QILRGLKYIHSANVLHRDLKPSNLLLN-TTCDLKICDFGLA---RVA----------DPDHDHTgflTEYV-ATRWYRAP 196
Cdd:cd14013 128 QILVALRKLHSTGIVHRDVKPQNIIVSeGDGQFKIIDLGAAadlRIGinyipkefllDPRYAPP---EQYImSTQTPSAP 204
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 66932916 197 EI--------MLNSKGYTKSIDIWSVGCILAEML-----SNRPIFPGKHYLDQLNHilgilgspsqeDLNciinlKARNY 263
Cdd:cd14013 205 PApvaaalspVLWQMNLPDRFDMYSAGVILLQMAfpnlrSDSNLIAFNRQLKQCDY-----------DLN-----AWRML 268
                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|
gi 66932916 264 LLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHKRIEVEQALAHPYL 313
Cdd:cd14013 269 VEPRASADLREGFEILDLDDGAGWDLVTKLIRYKPRGRLSASAALAHPYF 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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