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Conserved domains on  [gi|194018537|ref|NP_002757|]
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phosphoribosyl pyrophosphate synthase-associated protein 1 isoform 1 [Homo sapiens]

Protein Classification

phosphoribosyl pyrophosphate synthase-associated protein( domain architecture ID 11226557)

phosphoribosyl pyrophosphate synthase-associated protein seems to play a negative regulatory role in 5-phosphoribose 1-diphosphate synthesis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 196-379 1.93e-105

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


:

Pssm-ID: 434046  Cd Length: 184  Bit Score: 308.28  E-value: 1.93e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  196 NYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPPITVVGD 275
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRSRTVSRSLGLPEIIPKEKPPMTVVGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  276 VGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKTV 355
Cdd:pfam14572  81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKTI 160

                         170       180
                  ....*....|....*....|....
gi 194018537  356 DISLILSEAIRRIHNGESMAYLFR 379
Cdd:pfam14572 161 DISQLIAEAIRRIHNGESMSYLFR 184
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 38-155 1.80e-48

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


:

Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 159.89  E-value: 1.80e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537   38 RVFSANStaaCTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTAC 117
Cdd:pfam13793   2 KIFSGNS---NPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRAS 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 194018537  118 ARNIIGVIPYFPYSKQSKM-RKRGSIVCKLLASMLAKAG 155
Cdd:pfam13793  79 AKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 196-379 1.93e-105

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 308.28  E-value: 1.93e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  196 NYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPPITVVGD 275
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRSRTVSRSLGLPEIIPKEKPPMTVVGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  276 VGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKTV 355
Cdd:pfam14572  81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKTI 160

                         170       180
                  ....*....|....*....|....
gi 194018537  356 DISLILSEAIRRIHNGESMAYLFR 379
Cdd:pfam14572 161 DISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 38-379 2.52e-98

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 294.66  E-value: 2.52e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  38 RVFSANSTAactELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTAC 117
Cdd:COG0462    5 KIFSGNANP---ELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRAS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 118 ARNIIGVIPYFPYSKQ-SKMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEipN 196
Cdd:COG0462   82 ARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK--D 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 197 YRNAVIVakSPDA--AKRAQSYAERLRLGLAVIHGEaqcteldmddgRHSPpmvKNATVHpglelplmmakekppiTVVG 274
Cdd:COG0462  160 LEDLVVV--SPDVggVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVM----------------NIIG 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 275 DVGGRI----------AiivddiiddvESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEV 344
Cdd:COG0462  208 DVEGKTciivddmidtG----------GTLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPE 277

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 194018537 345 QKlQCPKIKTVDISLILSEAIRRIHNGESMAYLFR 379
Cdd:COG0462  278 EK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
37-379 7.71e-90

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 273.15  E-value: 7.71e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  37 YRVFSANStaaCTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTA 116
Cdd:PRK01259   1 MKLFAGNA---NPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 117 CARNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEip 195
Cdd:PRK01259  78 SAGRITAVIPYFGYARQDrKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQK-- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 196 NYRNAVIVakSPD--AAKRAQSYAERLRLGLAVIhgeaqcteldmdDGRHSPPMVknATVhpglelplmmakekppITVV 273
Cdd:PRK01259 156 NLENLVVV--SPDvgGVVRARALAKRLDADLAII------------DKRRPRANV--SEV----------------MNII 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 274 GDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIK 353
Cdd:PRK01259 204 GDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIR 283

                        330       340
                 ....*....|....*....|....*.
gi 194018537 354 TVDISLILSEAIRRIHNGESMAYLFR 379
Cdd:PRK01259 284 VLSVAPLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 37-379 5.75e-88

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 268.38  E-value: 5.75e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537   37 YRVFSANSTAactELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFII-QTIPRDVNTAVMELLIMAYALKT 115
Cdd:TIGR01251   1 MKIFSGSSNQ---ELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  116 ACARNIIGVIPYFPYSKQSKMRKRG-SIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEI 194
Cdd:TIGR01251  78 ASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  195 PNyrNAVIVakSPD--AAKRAQSYAERLRLGLAVIHGEaqcteldmddgRHSPPmvKNATVHPglelplmmakekppitV 272
Cdd:TIGR01251 158 LD--NPVVV--SPDagGVERAKKVADALGCPLAIIDKR-----------RISAT--NEVEVMN----------------L 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  273 VGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVqklQCPKI 352
Cdd:TIGR01251 205 VGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHEK---HKPKV 281

                         330       340
                  ....*....|....*....|....*..
gi 194018537  353 KTVDISLILSEAIRRIHNGESMAYLFR 379
Cdd:TIGR01251 282 SVISVAPLIAEAIRRIHNNESVSSLFD 308
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 38-155 1.80e-48

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 159.89  E-value: 1.80e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537   38 RVFSANStaaCTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTAC 117
Cdd:pfam13793   2 KIFSGNS---NPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRAS 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 194018537  118 ARNIIGVIPYFPYSKQSKM-RKRGSIVCKLLASMLAKAG 155
Cdd:pfam13793  79 AKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
 
Name Accession Description Interval E-value
Pribosyl_synth pfam14572
Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes ...
 196-379 1.93e-105

Phosphoribosyl synthetase-associated domain; This family includes several examples of enzymes from class EC:2.7.6.1, phosphoribosyl-pyrophosphate transferase.


Pssm-ID: 434046  Cd Length: 184  Bit Score: 308.28  E-value: 1.93e-105
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  196 NYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIHGEAQCTELDMDDGRHSPPMVKNATVHPGLELPLMMAKEKPPITVVGD 275
Cdd:pfam14572   1 DYRNAVIVARSPGSAKRATSFAERLRLGIAVIHGEQKEAESDEVDGRQSPPPYRSRTVSRSLGLPEIIPKEKPPMTVVGD 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  276 VGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKTV 355
Cdd:pfam14572  81 VGGRIAIIVDDMIDDVDSFVAAAELLKERGAYKIYVMATHGLLSSDAPRLLEASPIDEVVVTNTIPHEIQKMQCHKIKTI 160

                         170       180
                  ....*....|....*....|....
gi 194018537  356 DISLILSEAIRRIHNGESMAYLFR 379
Cdd:pfam14572 161 DISQLIAEAIRRIHNGESMSYLFR 184
PrsA COG0462
Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; ...
 38-379 2.52e-98

Phosphoribosylpyrophosphate synthetase [Nucleotide transport and metabolism]; Phosphoribosylpyrophosphate synthetase is part of the Pathway/BioSystem: Histidine biosynthesis, Purine biosynthesis


Pssm-ID: 440230 [Multi-domain]  Cd Length: 311  Bit Score: 294.66  E-value: 2.52e-98
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  38 RVFSANSTAactELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTAC 117
Cdd:COG0462    5 KIFSGNANP---ELAEEIAEYLGVPLGKAEVRRFSDGEIYVRIEESVRGRDVFVIQSTSPPVNDNLMELLIMIDALKRAS 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 118 ARNIIGVIPYFPYSKQ-SKMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEipN 196
Cdd:COG0462   82 ARRITAVIPYYGYARQdRKFRPREPITAKLVADLLEAAGADRVLTVDLHAPQIQGFFDIPVDHLYAAPLLADYIKSK--D 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 197 YRNAVIVakSPDA--AKRAQSYAERLRLGLAVIHGEaqcteldmddgRHSPpmvKNATVHpglelplmmakekppiTVVG 274
Cdd:COG0462  160 LEDLVVV--SPDVggVKRARAFAKRLGAPLAIIDKR-----------RPGA---NEVEVM----------------NIIG 207

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 275 DVGGRI----------AiivddiiddvESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEV 344
Cdd:COG0462  208 DVEGKTciivddmidtG----------GTLVEAAEALKEAGAKSVYAAATHGVLSGPAVERLENSPIDELVVTDTIPLPE 277

                        330       340       350
                 ....*....|....*....|....*....|....*
gi 194018537 345 QKlQCPKIKTVDISLILSEAIRRIHNGESMAYLFR 379
Cdd:COG0462  278 EK-RCDKIKVLSVAPLLAEAIRRIHEGESVSSLFD 311
PRK01259 PRK01259
ribose-phosphate diphosphokinase;
37-379 7.71e-90

ribose-phosphate diphosphokinase;


Pssm-ID: 234929 [Multi-domain]  Cd Length: 309  Bit Score: 273.15  E-value: 7.71e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  37 YRVFSANStaaCTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTA 116
Cdd:PRK01259   1 MKLFAGNA---NPELAEKIAKYLGIPLGKASVGRFSDGEISVEINENVRGKDVFIIQSTCAPTNDNLMELLIMIDALKRA 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 117 CARNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEip 195
Cdd:PRK01259  78 SAGRITAVIPYFGYARQDrKARSRVPITAKLVANLLETAGADRVLTMDLHADQIQGFFDIPVDNLYGSPILLEDIKQK-- 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 196 NYRNAVIVakSPD--AAKRAQSYAERLRLGLAVIhgeaqcteldmdDGRHSPPMVknATVhpglelplmmakekppITVV 273
Cdd:PRK01259 156 NLENLVVV--SPDvgGVVRARALAKRLDADLAII------------DKRRPRANV--SEV----------------MNII 203

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 274 GDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIK 353
Cdd:PRK01259 204 GDVEGRDCILVDDMIDTAGTLCKAAEALKERGAKSVYAYATHPVLSGGAIERIENSVIDELVVTDSIPLSEEAKKCDKIR 283

                        330       340
                 ....*....|....*....|....*.
gi 194018537 354 TVDISLILSEAIRRIHNGESMAYLFR 379
Cdd:PRK01259 284 VLSVAPLLAEAIRRISNEESVSSLFD 309
ribP_PPkin TIGR01251
ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In ...
 37-379 5.75e-88

ribose-phosphate pyrophosphokinase; Alternate name: phosphoribosylpyrophosphate synthetase In some systems, close homologs lacking enzymatic activity exist and perform regulatory functions. The model is designated subfamily rather than equivalog for this reason. [Purines, pyrimidines, nucleosides, and nucleotides, Purine ribonucleotide biosynthesis]


Pssm-ID: 273523 [Multi-domain]  Cd Length: 308  Bit Score: 268.38  E-value: 5.75e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537   37 YRVFSANSTAactELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFII-QTIPRDVNTAVMELLIMAYALKT 115
Cdd:TIGR01251   1 MKIFSGSSNQ---ELAQKVAKNLGLPLGDVEVKRFPDGELYVRINESVRGKDVFIIqQSTSAPVNDNLMELLIMIDALKR 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  116 ACARNIIGVIPYFPYSKQSKMRKRG-SIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEI 194
Cdd:TIGR01251  78 ASAKSITAVIPYYGYARQDKKFKSRePISAKLVANLLETAGADRVLTVDLHSPQIQGFFDVPVDNLYASPVLAEYLKKKI 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  195 PNyrNAVIVakSPD--AAKRAQSYAERLRLGLAVIHGEaqcteldmddgRHSPPmvKNATVHPglelplmmakekppitV 272
Cdd:TIGR01251 158 LD--NPVVV--SPDagGVERAKKVADALGCPLAIIDKR-----------RISAT--NEVEVMN----------------L 204

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  273 VGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVqklQCPKI 352
Cdd:TIGR01251 205 VGDVEGKDVVIVDDIIDTGGTIAKAAEILKSAGAKRVIAAATHGVFSGPAIERIANAGVEEVIVTNTIPHEK---HKPKV 281

                         330       340
                  ....*....|....*....|....*..
gi 194018537  353 KTVDISLILSEAIRRIHNGESMAYLFR 379
Cdd:TIGR01251 282 SVISVAPLIAEAIRRIHNNESVSSLFD 308
PRK03092 PRK03092
ribose-phosphate diphosphokinase;
51-378 1.92e-66

ribose-phosphate diphosphokinase;


Pssm-ID: 179535 [Multi-domain]  Cd Length: 304  Bit Score: 212.89  E-value: 1.92e-66
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  51 LAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTACARNIIGVIPYFPY 130
Cdd:PRK03092   1 LAEEVAKELGVEVTPTTAYDFANGEIYVRFEESVRGCDAFVLQSHTAPINKWLMEQLIMIDALKRASAKRITVVLPFYPY 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 131 SKQSKM-RKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIPNyRNAVIVakSPDA 209
Cdd:PRK03092  81 ARQDKKhRGREPISARLVADLFKTAGADRIMTVDLHTAQIQGFFDGPVDHLFAMPLLADYVRDKYDL-DNVTVV--SPDA 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 210 A--KRAQSYAERL-RLGLAVIHgeaqcteldmddGRHSPPMVKNATVHpglelplmmakekppiTVVGDVGGRIAIIVDD 286
Cdd:PRK03092 158 GrvRVAEQWADRLgGAPLAFIH------------KTRDPTVPNQVVAN----------------RVVGDVEGRTCVLVDD 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 287 IIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKlQCPKIKTVDISLILSEAIR 366
Cdd:PRK03092 210 MIDTGGTIAGAVRALKEAGAKDVIIAATHGVLSGPAAERLKNCGAREVVVTDTLPIPEEK-RFDKLTVLSIAPLLARAIR 288

                        330
                 ....*....|..
gi 194018537 367 RIHNGESMAYLF 378
Cdd:PRK03092 289 EVFEDGSVTSLF 300
PLN02369 PLN02369
ribose-phosphate pyrophosphokinase
 50-379 2.64e-65

ribose-phosphate pyrophosphokinase


Pssm-ID: 215209 [Multi-domain]  Cd Length: 302  Bit Score: 209.94  E-value: 2.64e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  50 ELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTACARNIIGVIPYFP 129
Cdd:PLN02369   2 ALSQEIACYLGLELGKITIKRFADGEIYVQLQESVRGCDVFLVQPTCPPANENLMELLIMIDACRRASAKRITAVIPYFG 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 130 YSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIPNYRNAVIVakSPD 208
Cdd:PLN02369  82 YARADrKTQGRESIAAKLVANLITEAGADRVLACDLHSGQSMGYFDIPVDHVYGQPVILDYLASKTISSPDLVVV--SPD 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 209 AAK--RAQSYAERLR-LGLAVIhgeaqcteldmDDGRHSPPMVKnatvhpglelplmmakekpPITVVGDVGGRIAIIVD 285
Cdd:PLN02369 160 VGGvaRARAFAKKLSdAPLAIV-----------DKRRQGHNVAE-------------------VMNLIGDVKGKVAIMVD 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 286 DIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKlQCPKIKTVDISLILSEAI 365
Cdd:PLN02369 210 DMIDTAGTITKGAALLHQEGAREVYACATHAVFSPPAIERLSSGLFQEVIVTNTIPVSEKN-YFPQLTVLSVANLLGETI 288

                        330
                 ....*....|....
gi 194018537 366 RRIHNGESMAYLFR 379
Cdd:PLN02369 289 WRVHDDCSVSSIFD 302
PRK04923 PRK04923
ribose-phosphate diphosphokinase;
39-378 3.08e-65

ribose-phosphate diphosphokinase;


Pssm-ID: 179893 [Multi-domain]  Cd Length: 319  Bit Score: 210.17  E-value: 3.08e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  39 VFSANstaACTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTACA 118
Cdd:PRK04923   9 VFSGN---ANKPLAQSICKELGVRMGKALVTRFSDGEVQVEIEESVRRQEVFVIQPTCAPSAENLMELLVLIDALKRASA 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 119 RNIIGVIPYFPYSKQSK-MRK-RGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIpN 196
Cdd:PRK04923  86 ASVTAVIPYFGYSRQDRrMRSsRVPITAKVAAKMISAMGADRVLTVDLHADQIQGFFDVPVDNVYASPLLLADIWRAY-G 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 197 YRNAVIVAKSPDAAKRAQSYAERL-RLGLAVIhgeaqcteldmdDGRHspPMVKNATVhpglelplmmakekppITVVGD 275
Cdd:PRK04923 165 TDNLIVVSPDVGGVVRARAVAKRLdDADLAII------------DKRR--PRANVATV----------------MNIIGD 214

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 276 VGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIKTV 355
Cdd:PRK04923 215 VQGKTCVLVDDLVDTAGTLCAAAAALKQRGALKVVAYITHPVLSGPAVDNINNSQLDELVVTDTIPLSEAARACAKIRQL 294

                        330       340
                 ....*....|....*....|...
gi 194018537 356 DISLILSEAIRRIHNGESMAYLF 378
Cdd:PRK04923 295 SVAELLAETIRRIAFGESVSSLY 317
PRK02269 PRK02269
ribose-phosphate diphosphokinase;
38-378 3.63e-65

ribose-phosphate diphosphokinase;


Pssm-ID: 167353 [Multi-domain]  Cd Length: 320  Bit Score: 210.03  E-value: 3.63e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  38 RVFSANSTaacTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTAC 117
Cdd:PRK02269   7 KLFALSSN---KELAEKVAQEIGIELGKSSVRQFSDGEIQVNIEESIRGHHVFILQSTSSPVNDNLMEILIMVDALKRAS 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 118 ARNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIPN 196
Cdd:PRK02269  84 AESINVVMPYYGYARQDrKARSREPITSKLVANMLEVAGVDRLLTVDLHAAQIQGFFDIPVDHLMGAPLIADYFDRRGLV 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 197 YRNAVIVakSPDAA--KRAQSYAERLRLGLAVIhgeaqcteldmdDGRHSPPMVKNATVhpglelplmmakekppITVVG 274
Cdd:PRK02269 164 GDDVVVV--SPDHGgvTRARKLAQFLKTPIAII------------DKRRSVDKMNTSEV----------------MNIIG 213

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 275 DVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLqCPKIKT 354
Cdd:PRK02269 214 NVKGKKCILIDDMIDTAGTICHAADALAEAGATEVYASCTHPVLSGPALDNIQKSAIEKLVVLDTIYLPEERL-IDKIEQ 292

                        330       340
                 ....*....|....*....|....
gi 194018537 355 VDISLILSEAIRRIHNGESMAYLF 378
Cdd:PRK02269 293 ISIADLLGEAIIRIHEKRPLSPLF 316
PRK02458 PRK02458
ribose-phosphate pyrophosphokinase; Provisional
 30-379 5.54e-60

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235039 [Multi-domain]  Cd Length: 323  Bit Score: 196.88  E-value: 5.54e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  30 MNAARTGYRVFSANSTaacTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIM 109
Cdd:PRK02458   3 ERYADKQIKLFSLNSN---LEIAEKIAQAAGVPLGKLSSRQFSDGEIMINIEESVRGDDIYIIQSTSFPVNDHLWELLIM 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 110 AYALKTACARNIIGVIPYFPYSKQSKMRK-RGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQ 188
Cdd:PRK02458  80 IDACKRASANTVNVVLPYFGYARQDRIAKpREPITAKLVANMLVKAGVDRVLTLDLHAVQVQGFFDIPVDNLFTVPLFAK 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 189 YIQEEIPNYRNAVIVAKSPDAAKRAQSYAERLRLGLAVIhgeaqctELDMDDGrhsppmvknatvhpglelplmmakEKP 268
Cdd:PRK02458 160 HYCKKGLSGSDVVVVSPKNSGIKRARSLAEYLDAPIAII-------DYAQDDS------------------------ERE 208

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 269 PITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVpheVQKLQ 348
Cdd:PRK02458 209 EGYIIGDVAGKKAILIDDILNTGKTFAEAAKIVEREGATEIYAVASHGLFAGGAAEVLENAPIKEILVTDSV---ATKER 285

                        330       340       350
                 ....*....|....*....|....*....|..
gi 194018537 349 CPK-IKTVDISLILSEAIRRIHNGESMAYLFR 379
Cdd:PRK02458 286 VPKnVTYLSASELIADAIIRIHERKPLSPLFA 317
PRK02812 PRK02812
ribose-phosphate pyrophosphokinase; Provisional
 38-379 2.33e-56

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 235072 [Multi-domain]  Cd Length: 330  Bit Score: 187.64  E-value: 2.33e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  38 RVFSANSTAActeLAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTAC 117
Cdd:PRK02812  23 RLFSGSSNPA---LAQEVARYLGMDLGPMIRKRFADGELYVQIQESIRGCDVYLIQPTCAPVNDHLMELLIMVDACRRAS 99

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 118 ARNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEipN 196
Cdd:PRK02812 100 ARQITAVIPYYGYARADrKTAGRESITAKLVANLITKAGADRVLAMDLHSAQIQGYFDIPCDHVYGSPVLLDYLASK--N 177

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 197 YRNAVIVakSPD--AAKRAQSYAERLRLG-LAVIhgeaqcteldmdDGRHSPPMVKNAtvhpglelplmmakekppITVV 273
Cdd:PRK02812 178 LEDIVVV--SPDvgGVARARAFAKKLNDApLAII------------DKRRQAHNVAEV------------------LNVI 225

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 274 GDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEvQKLQCPKIK 353
Cdd:PRK02812 226 GDVKGKTAILVDDMIDTGGTICEGARLLRKEGAKQVYACATHAVFSPPAIERLSSGLFEEVIVTNTIPVP-EERRFPQLK 304

                        330       340
                 ....*....|....*....|....*.
gi 194018537 354 TVDISLILSEAIRRIHNGESMAYLFR 379
Cdd:PRK02812 305 VLSVANMLGEAIWRIHEESSVSSMFR 330
PTZ00145 PTZ00145
phosphoribosylpyrophosphate synthetase; Provisional
 39-378 2.56e-52

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 240290 [Multi-domain]  Cd Length: 439  Bit Score: 180.07  E-value: 2.56e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  39 VFSANSTAActeLAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTACA 118
Cdd:PTZ00145 122 LFSGSSNPL---LSKNIADHLGTILGRVHLKRFADGEVSMQFLESIRGKDVYIIQPTCPPVNENLIELLLMISTCRRASA 198

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 119 RNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFS--FPVDNLRASPFLLQYIQEEiP 195
Cdd:PTZ00145 199 KKITAVIPYYGYARQDrKLSSRVPISAADVARMIEAMGVDRVVAIDLHSGQIQGFFGprVPVDNLEAQLIGLDYFTKK-D 277

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 196 NYRnAVIVakSPDAAK--RAQSYAERLrlglaVIHGEAQCTeLDMddgrhsppMVKNATvhpglelplmMAKEKPPITVV 273
Cdd:PTZ00145 278 LYK-PVIV--SPDAGGvyRARKFQDGL-----NHRGISDCG-IAM--------LIKQRT----------KPNEIEKMDLV 330

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 274 GDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKLQCPKIK 353
Cdd:PTZ00145 331 GNVYDSDVIIVDDMIDTSGTLCEAAKQLKKHGARRVFAFATHGLFSGPAIERIEASPLEEVVVTDTVKSNKNIDSCKKIT 410

                        330       340
                 ....*....|....*....|....*
gi 194018537 354 TVDISLILSEAIRRIHNGESMAYLF 378
Cdd:PTZ00145 411 KLSVSVLVADAIRRIHQKESLNDLF 435
PRK00553 PRK00553
ribose-phosphate pyrophosphokinase; Provisional
 30-378 3.63e-51

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 179062 [Multi-domain]  Cd Length: 332  Bit Score: 174.33  E-value: 3.63e-51
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  30 MNAARTGYRVFSANSTaacTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIM 109
Cdd:PRK00553   3 LSIDKSNHVIFSLSKA---KKLVDSICRKLSMKPGEIVIQKFADGETYIRFDESVRNKDVVIFQSTCSPVNDSLMELLIA 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 110 AYALKTACARNIIGVIPYFPYSKQS-KMRKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQ 188
Cdd:PRK00553  80 IDALKRGSAKSITAILPYYGYARQDrKTAGREPITSKLVADLLTKAGVTRVTLTDIHSDQTQGFFDIPVDILRTYHVFLS 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 189 YIQEEIpNYRNAVIVakSPD--AAKRAQSYAERLRLGLAVIhgeaqcteldmdDGRHSPPMVKNAtvhpglelplmmake 266
Cdd:PRK00553 160 RVLELL-GKKDLVVV--SPDygGVKRARLIAESLELPLAII------------DKRRPKHNVAES--------------- 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 267 kppITVVGDVGGRIAIIVDDIIDDVESFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEES----SVDEVVVTNTVPH 342
Cdd:PRK00553 210 ---INVLGEVKNKNCLIVDDMIDTGGTVIAAAKLLKKQKAKKVCVMATHGLFNKNAIQLFDEAfkkkLIDKLFVSNSIPQ 286

                        330       340       350
                 ....*....|....*....|....*....|....*.
gi 194018537 343 EVQKlQCPKIKTVDISLILSEAIRRIHNGESMAYLF 378
Cdd:PRK00553 287 TKFE-KKPQFKVVDLAHLYEEVLLCYANGGSISAIY 321
Pribosyltran_N pfam13793
N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found ...
 38-155 1.80e-48

N-terminal domain of ribose phosphate pyrophosphokinase; This family is frequently found N-terminal to the Pribosyltran, pfam00156.


Pssm-ID: 433483 [Multi-domain]  Cd Length: 117  Bit Score: 159.89  E-value: 1.80e-48
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537   38 RVFSANStaaCTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDVNTAVMELLIMAYALKTAC 117
Cdd:pfam13793   2 KIFSGNS---NPELAEKIAKRLGIPLGKATVSRFSDGEIYVRIEESVRGKDVFIIQSTCPPVNDNLMELLIMIDALKRAS 78

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 194018537  118 ARNIIGVIPYFPYSKQSKM-RKRGSIVCKLLASMLAKAG 155
Cdd:pfam13793  79 AKRITAVIPYFGYARQDRKdKPREPITAKLVADLLEAAG 117
PRK00934 PRK00934
ribose-phosphate pyrophosphokinase; Provisional
 51-347 1.81e-37

ribose-phosphate pyrophosphokinase; Provisional


Pssm-ID: 234868 [Multi-domain]  Cd Length: 285  Bit Score: 136.58  E-value: 1.81e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  51 LAKRITERLGAELgksvVYQETN----GETRVEIKESVRGQDIFIIQTIPRDvNTAVMELLIMAYALKTACARNIIGVIP 126
Cdd:PRK00934  11 LASEVARLLNTEL----ALVETKrfpdGELYVRILGEIDGEDVVIISTTYPQ-DENLVELLLLIDALRDEGAKSITLVIP 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 127 YFPYSKQSKMRKRG-SIVCKLLASMLAKAGlTHIITMDLHQKEIQGFFSFPVDNLRASPFLLQYIQEEIpnyRNAVIVAk 205
Cdd:PRK00934  86 YLGYARQDKRFKPGePISARAIAKIISAYY-DRIITINIHEPSILEFFPIPFINLDAAPLIAEYIGDKL---DDPLVLA- 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 206 sPD--AAKRAQSYAERLrlGLAVIHGEAQcteldmddgRHSPPMVKNATVHpglelplMMAKEKPpITVVGDV---GGRI 280
Cdd:PRK00934 161 -PDkgALELAKEAAEIL--GCEYDYLEKT---------RISPTEVEIAPKN-------LDVKGKD-VLIVDDIistGGTM 220

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 194018537 281 AIivddiiddvesfvaAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQKL 347
Cdd:PRK00934 221 AT--------------AIKILKEQGAKKVYVACVHPVLVGDAILKLYNAGVDEIIVTDTLESEVSKI 273
PRK06827 PRK06827
phosphoribosylpyrophosphate synthetase; Provisional
 73-380 5.20e-30

phosphoribosylpyrophosphate synthetase; Provisional


Pssm-ID: 180714 [Multi-domain]  Cd Length: 382  Bit Score: 118.90  E-value: 5.20e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  73 NGETRVEIKESVRGQDIFIIQ--------------TIPRDVNTAVMEL--LIMAYALKtacARNIIGVIPYFPYSKQSKM 136
Cdd:PRK06827  64 NGEAKGEILESVRGKDIYILQdvgnysvtynmfgeKNHMSPDDHFQDLkrTIDAIRGK---ARRITVIMPFLYESRQHKR 140

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 137 RKRGSIVCKLLASMLAKAGLTHIITMDLHQKEIQGffSFPV---DNLRASPFLLQYIQEEIPNYR----NAVIVakSPD- 208
Cdd:PRK06827 141 KGRESLDCALALQELEELGVDNIITFDAHDPRIEN--AIPLmgfENLYPSYQIIKALLKNEKDLEidkdHLMVI--SPDt 216

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 209 -AAKRAQSYAERLRLGLAVIHGEaqcteldmddgRHSPPMVKNatvhpglelplmmakeKPPITVV----GDVGGRIAII 283
Cdd:PRK06827 217 gAMDRAKYYASVLGVDLGLFYKR-----------RDYSRVVNG----------------RNPIVAHeflgRDVEGKDVLI 269

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 284 VDDIIDDVESFVAAAEILKERGAYKIYVMATHGiLSAEAPRLI----EESSVDEVVVTNTVPHEVQKLQCPKIKTVDISL 359
Cdd:PRK06827 270 VDDMIASGGSMIDAAKELKSRGAKKIIVAATFG-FFTNGLEKFdkayEEGYFDRIIGTNLVYHPEELLSKPWYIEVDMSK 348

                        330       340
                 ....*....|....*....|.
gi 194018537 360 ILSEAIRRIHNGESMAYLFRN 380
Cdd:PRK06827 349 LIARIIDALNHDVSLSKLLDP 369
PRK07199 PRK07199
ribose-phosphate diphosphokinase;
48-367 1.45e-14

ribose-phosphate diphosphokinase;


Pssm-ID: 235960 [Multi-domain]  Cd Length: 301  Bit Score: 73.43  E-value: 1.45e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537  48 CTELAKRITERLGAELGKSVVYQETNGETRVEIKESVRGQDIFIIQTIPRDvNTAVMELLIMAYALKTACARNIIGVIPY 127
Cdd:PRK07199  11 NEAAAGRLAAALGVEVGRIELHRFPDGESYVRLDSPVAGRTVVLVCSLDRP-DEKLLPLLFAAEAARELGARRVGLVAPY 89

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 128 FPYSKQSKMRKRGSIVC-KLLASMLAkAGLTHIITMD--LHQ-KEIQGFFSFPVDNLRASPFLLQYIQEEIPnyrNAVIV 203
Cdd:PRK07199  90 LAYMRQDIAFHPGEAISqRHFARLLS-GSFDRLVTVDphLHRyPSLSEVYPIPAVVLSAAPAIAAWIRAHVP---RPLLI 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 204 AksPDAAKR--AQSYAERLRLGLAVihgeaqCTELdmddgRHSPPMVK----NATVHPGlelplmmakeKPPItVVGDV- 276
Cdd:PRK07199 166 G--PDEESEqwVAAVAERAGAPHAV------LRKT-----RHGDRDVEislpDAAPWAG----------RTPV-LVDDIv 221

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 194018537 277 -GGRiaiivddiiddveSFVAAAEILKERGAYKIYVMATHGILSAEAPRLIEESSVDEVVVTNTVPHEVQklqcpkikTV 355
Cdd:PRK07199 222 sTGR-------------TLIEAARQLRAAGAASPDCVVVHALFAGDAYSALAAAGIARVVSTDTVPHPSN--------AI 280

                        330
                 ....*....|..
gi 194018537 356 DISLILSEAIRR 367
Cdd:PRK07199 281 SLAPLLAEALRR 292
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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