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Conserved domains on  [gi|19923149|ref|NP_002862|]
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guanine nucleotide exchange factor MSS4 [Homo sapiens]

Protein Classification

RabGEF domain-containing protein( domain architecture ID 10516710)

RabGEF domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Mss4 pfam04421
Mss4 protein;
27-122 8.87e-56

Mss4 protein;


:

Pssm-ID: 461301  Cd Length: 94  Bit Score: 168.59  E-value: 8.87e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923149    27 GSRVLQPGTALFSRRQLFLPSMRKKpaLSDGSNPDGDLLQEHWLVEDMFIFENVGFTKDVGNIKFLVCADCEIGPIGWHC 106
Cdd:pfam04421   1 GSVVLNPGTATFVEKELFLPLMRKK--SAGDEDPNGETLSDFWLVEDMYTFENVGFSKTVDNVKYLICADCEKGPIGWHD 78
                          90
                  ....*....|....*.
gi 19923149   107 LDDKNSFYVALERVSH 122
Cdd:pfam04421  79 LSDKKSFYLALERVVH 94
 
Name Accession Description Interval E-value
Mss4 pfam04421
Mss4 protein;
27-122 8.87e-56

Mss4 protein;


Pssm-ID: 461301  Cd Length: 94  Bit Score: 168.59  E-value: 8.87e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923149    27 GSRVLQPGTALFSRRQLFLPSMRKKpaLSDGSNPDGDLLQEHWLVEDMFIFENVGFTKDVGNIKFLVCADCEIGPIGWHC 106
Cdd:pfam04421   1 GSVVLNPGTATFVEKELFLPLMRKK--SAGDEDPNGETLSDFWLVEDMYTFENVGFSKTVDNVKYLICADCEKGPIGWHD 78
                          90
                  ....*....|....*.
gi 19923149   107 LDDKNSFYVALERVSH 122
Cdd:pfam04421  79 LSDKKSFYLALERVVH 94
RabGEF cd00246
Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely ...
19-123 2.02e-55

Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely regulates the function of Rab GTPase by promoting exchange of GDP for GTP; members of the Rab subfamily of Ras GTPases are important in vesicular transport;


Pssm-ID: 238150  Cd Length: 103  Bit Score: 168.12  E-value: 2.02e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923149  19 KAVLCQRCGSRVL--QPGTALFSRRQLFLPSMRKKPalsdGSNPDGDLLQEHWLVEDMFIFENVGFTKDVGNIKFLVCAD 96
Cdd:cd00246   1 KAVLCQRCGSRVLtiQPGTVLFLPRQLFLPSMRKKP----GSNPDGDLLEDHWLVVDMFTFENVGFSKDVGNLKYLVCAD 76
                        90       100
                ....*....|....*....|....*..
gi 19923149  97 CEIGPIGWHCLDDKNSFYVALERVSHE 123
Cdd:cd00246  77 CEKGPIGYHCLDDKNSEYVALERVSHE 103
 
Name Accession Description Interval E-value
Mss4 pfam04421
Mss4 protein;
27-122 8.87e-56

Mss4 protein;


Pssm-ID: 461301  Cd Length: 94  Bit Score: 168.59  E-value: 8.87e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923149    27 GSRVLQPGTALFSRRQLFLPSMRKKpaLSDGSNPDGDLLQEHWLVEDMFIFENVGFTKDVGNIKFLVCADCEIGPIGWHC 106
Cdd:pfam04421   1 GSVVLNPGTATFVEKELFLPLMRKK--SAGDEDPNGETLSDFWLVEDMYTFENVGFSKTVDNVKYLICADCEKGPIGWHD 78
                          90
                  ....*....|....*.
gi 19923149   107 LDDKNSFYVALERVSH 122
Cdd:pfam04421  79 LSDKKSFYLALERVVH 94
RabGEF cd00246
Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely ...
19-123 2.02e-55

Nucleotide exchange factor for Rab-like small GTPases (RabGEF), Mss4 type; RabGEF positely regulates the function of Rab GTPase by promoting exchange of GDP for GTP; members of the Rab subfamily of Ras GTPases are important in vesicular transport;


Pssm-ID: 238150  Cd Length: 103  Bit Score: 168.12  E-value: 2.02e-55
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923149  19 KAVLCQRCGSRVL--QPGTALFSRRQLFLPSMRKKPalsdGSNPDGDLLQEHWLVEDMFIFENVGFTKDVGNIKFLVCAD 96
Cdd:cd00246   1 KAVLCQRCGSRVLtiQPGTVLFLPRQLFLPSMRKKP----GSNPDGDLLEDHWLVVDMFTFENVGFSKDVGNLKYLVCAD 76
                        90       100
                ....*....|....*....|....*..
gi 19923149  97 CEIGPIGWHCLDDKNSFYVALERVSHE 123
Cdd:cd00246  77 CEKGPIGYHCLDDKNSEYVALERVSHE 103
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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