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Conserved domains on  [gi|4507239|ref|NP_003136|]
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translocon-associated protein subunit beta precursor [Homo sapiens]

Protein Classification

translocon-associated protein subunit beta( domain architecture ID 12065704)

translocon-associated protein subunit beta is part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins

Gene Ontology:  GO:0006613
PubMed:  28218252

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAP_beta pfam05753
Translocon-associated protein beta (TRAPB); This family consists of several eukaryotic ...
 4-179 1.10e-89

Translocon-associated protein beta (TRAPB); This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion.


:

Pssm-ID: 399046  Cd Length: 178  Bit Score: 259.97  E-value: 1.10e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507239      4 LSFVVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRI 83
Cdd:pfam05753   1 LALALLALAALAQDDAPARLLVKKKILNRYLVEGRDLTVTYTIYNVGSSAAYDVSLVDNSFPEEAFEVVSGSLSASWERL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507239     84 APASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGP-VVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIG 162
Cdd:pfam05753  81 APGSNVSHIFVVEPKKSGYFNFTAAEVTYRPSEDGAeLQVAYSSPPGEGGIFAERDYGKKFSLHLLDWVAFAVMTLPSLG 160

                         170
                  ....*....|....*..
gi 4507239    163 IPLLLWYSSKRKYDTPK 179
Cdd:pfam05753 161 IPYLLWWVSKSKYETSK 177
 
Name Accession Description Interval E-value
TRAP_beta pfam05753
Translocon-associated protein beta (TRAPB); This family consists of several eukaryotic ...
 4-179 1.10e-89

Translocon-associated protein beta (TRAPB); This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion.


Pssm-ID: 399046  Cd Length: 178  Bit Score: 259.97  E-value: 1.10e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507239      4 LSFVVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRI 83
Cdd:pfam05753   1 LALALLALAALAQDDAPARLLVKKKILNRYLVEGRDLTVTYTIYNVGSSAAYDVSLVDNSFPEEAFEVVSGSLSASWERL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507239     84 APASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGP-VVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIG 162
Cdd:pfam05753  81 APGSNVSHIFVVEPKKSGYFNFTAAEVTYRPSEDGAeLQVAYSSPPGEGGIFAERDYGKKFSLHLLDWVAFAVMTLPSLG 160

                         170
                  ....*....|....*..
gi 4507239    163 IPLLLWYSSKRKYDTPK 179
Cdd:pfam05753 161 IPYLLWWVSKSKYETSK 177
 
Name Accession Description Interval E-value
TRAP_beta pfam05753
Translocon-associated protein beta (TRAPB); This family consists of several eukaryotic ...
 4-179 1.10e-89

Translocon-associated protein beta (TRAPB); This family consists of several eukaryotic translocon-associated protein beta (TRAPB) or signal sequence receptor beta subunit (SSR-beta) proteins. The normal translocation of nascent polypeptides into the lumen of the endoplasmic reticulum (ER) is thought to be aided in part by a translocon-associated protein (TRAP) complex consisting of 4 protein subunits. The association of mature proteins with the ER and Golgi, or other intracellular locales, such as lysosomes, depends on the initial targeting of the nascent polypeptide to the ER membrane. A similar scenario must also exist for proteins destined for secretion.


Pssm-ID: 399046  Cd Length: 178  Bit Score: 259.97  E-value: 1.10e-89
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507239      4 LSFVVLALFAVTQAEEGARLLASKSLLNRYAVEGRDLTLQYNIYNVGSSAALDVELSDDSFPPEDFGIVSGMLNVKWDRI 83
Cdd:pfam05753   1 LALALLALAALAQDDAPARLLVKKKILNRYLVEGRDLTVTYTIYNVGSSAAYDVSLVDNSFPEEAFEVVSGSLSASWERL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507239     84 APASNVSHTVVLRPLKAGYFNFTSATITYLAQEDGP-VVIGSTSAPGQGGILAQREFDRRFSPHFLDWAAFGVMTLPSIG 162
Cdd:pfam05753  81 APGSNVSHIFVVEPKKSGYFNFTAAEVTYRPSEDGAeLQVAYSSPPGEGGIFAERDYGKKFSLHLLDWVAFAVMTLPSLG 160

                         170
                  ....*....|....*..
gi 4507239    163 IPLLLWYSSKRKYDTPK 179
Cdd:pfam05753 161 IPYLLWWVSKSKYETSK 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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