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Conserved domains on  [gi|4507531|ref|NP_003256|]
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toll-like receptor 3 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
755-900 7.85e-25

Toll - interleukin 1 - resistance;


:

Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 100.86  E-value: 7.85e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531     755 EYAAYIIHAYKDkdWVWEHFSSMEKEDQ-SLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCkRFKVH 833
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLrGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWC-LDELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4507531     834 HAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKShcILNWPvqKERIGAFRHKLQVALGSK 900
Cdd:smart00255  78 AALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN--YLKWP--EDEKEQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-309 1.22e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   36 DCSHLKLTQVPDDLP--TNITVLNLTHNQLRRLPAAnFTRYSQLTSLDVGFNTISKLEPELcQKLPMLKVLNLQHNELSQ 113
Cdd:COG4886 119 DLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITD 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  114 LSDkTFAFCTNLTELHLMSNSIQKIkNNPFVKQKNLITLDLSHNGLSS-------TKLgtqvqlenlQELLLSNNKIQAL 186
Cdd:COG4886 197 LPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDlpelgnlTNL---------EELDLSNNQLTDL 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  187 KSEeldiFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNT 266
Cdd:COG4886 266 PPL----ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4507531  267 TFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNN 309
Cdd:COG4886 342 LSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384
Tlr3_TMD pfam17968
Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR ...
 698-730 2.25e-13

Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.


:

Pssm-ID: 465595  Cd Length: 33  Bit Score: 64.63  E-value: 2.25e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 4507531    698 DSAPFELFFMINTSILLIFIFIVLLIHFEGWRI 730
Cdd:pfam17968   1 DSAPFKLLFVISSTAVLLFIFIVLLIHFQGWRI 33
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
284-630 5.60e-11

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 5.60e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  284 NNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNME 363
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  364 DNDIPGIKSNMFTGLINLKYLSLSNSfTSLRTLTNetfvslahspLHILNLTKNKISKIeSDAFSWLGHLEVLDLGLNEI 443
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGN-EELSNLTN----------LESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  444 GQelTGQEWRGLENIFEIYLSYNKYLQLtrnsfalvpslqrlmlrrvalknvdssPSPFQPLRNLTILDLSNNNIANIND 523
Cdd:COG4886 149 TD--LPEPLGNLTNLKSLDLSNNQLTDL---------------------------PEELGNLTNLKELDLSNNQITDLPE 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  524 DmLEGLEKLEILDLQHNNLARLwkhanPGGpiyfLKGLSHLHILNLESNGFDEIPveVFKDLFELKIIDLGLNNLNTLPA 603
Cdd:COG4886 200 P-LGNLTNLEELDLSGNQLTDL-----PEP----LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP 267

                       330       340
                ....*....|....*....|....*..
gi 4507531  604 SVFNNQvsLKSLNLQKNLITSVEKKVF 630
Cdd:COG4886 268 LANLTN--LKTLDLSNNQLTDLKLKEL 292
LRRCT smart00082
Leucine rich repeat C-terminal domain;
645-697 4.02e-07

Leucine rich repeat C-terminal domain;


:

Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 4.02e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 4507531     645 NPFDCTCEsIAWFVNWINET-HTNIPElssHYLCNTPPHYHGfPVRLFDTSS--CK 697
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQANeHLQDPV---DLRCASPSSLRG-PLLELLHSEfkCP 51
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
755-900 7.85e-25

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 100.86  E-value: 7.85e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531     755 EYAAYIIHAYKDkdWVWEHFSSMEKEDQ-SLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCkRFKVH 833
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLrGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWC-LDELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4507531     834 HAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKShcILNWPvqKERIGAFRHKLQVALGSK 900
Cdd:smart00255  78 AALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN--YLKWP--EDEKEQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-309 1.22e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   36 DCSHLKLTQVPDDLP--TNITVLNLTHNQLRRLPAAnFTRYSQLTSLDVGFNTISKLEPELcQKLPMLKVLNLQHNELSQ 113
Cdd:COG4886 119 DLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITD 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  114 LSDkTFAFCTNLTELHLMSNSIQKIkNNPFVKQKNLITLDLSHNGLSS-------TKLgtqvqlenlQELLLSNNKIQAL 186
Cdd:COG4886 197 LPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDlpelgnlTNL---------EELDLSNNQLTDL 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  187 KSEeldiFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNT 266
Cdd:COG4886 266 PPL----ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4507531  267 TFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNN 309
Cdd:COG4886 342 LSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384
Tlr3_TMD pfam17968
Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR ...
 698-730 2.25e-13

Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.


Pssm-ID: 465595  Cd Length: 33  Bit Score: 64.63  E-value: 2.25e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 4507531    698 DSAPFELFFMINTSILLIFIFIVLLIHFEGWRI 730
Cdd:pfam17968   1 DSAPFKLLFVISSTAVLLFIFIVLLIHFQGWRI 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-542 3.18e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 3.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531    72 TRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELS-QLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKqkNLI 150
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIP--NLE 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   151 TLDLSHNGLSStklgtqvqlenlqelllsnnKIQAlkseelDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNN 230
Cdd:PLN00113 144 TLDLSNNMLSG--------------------EIPN------DIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   231 VQLgpslTEKLCLELANT-SIRNLSLSNSQLSTTSNTTFLGLkwTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNN 309
Cdd:PLN00113 198 NQL----VGQIPRELGQMkSLKWIYLGYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNK 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   310 IQHLFSHSLHGLFNVRYLNLKRSFTKQSIslaslPKIddfsFQWLKCLEHLNMEDNDIPG----------------IKSN 373
Cdd:PLN00113 272 LSGPIPPSIFSLQKLISLDLSDNSLSGEI-----PEL----VIQLQNLEILHLFSNNFTGkipvaltslprlqvlqLWSN 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   374 MFTGLINlKYLSLSNSFTSLRTLTN-------ETFVSLAHSPLHIL--NLTKNKISKIESDAFSwlghLEVLDLGLNEIG 444
Cdd:PLN00113 343 KFSGEIP-KNLGKHNNLTVLDLSTNnltgeipEGLCSSGNLFKLILfsNSLEGEIPKSLGACRS----LRRVRLQDNSFS 417

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   445 QELTgQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVA-------------LKNVDSS--------PSPFQ 503
Cdd:PLN00113 418 GELP-SEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKffgglpdsfgskrLENLDLSrnqfsgavPRKLG 496

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 4507531   504 PLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNL 542
Cdd:PLN00113 497 SLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
284-630 5.60e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 5.60e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  284 NNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNME 363
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  364 DNDIPGIKSNMFTGLINLKYLSLSNSfTSLRTLTNetfvslahspLHILNLTKNKISKIeSDAFSWLGHLEVLDLGLNEI 443
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGN-EELSNLTN----------LESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  444 GQelTGQEWRGLENIFEIYLSYNKYLQLtrnsfalvpslqrlmlrrvalknvdssPSPFQPLRNLTILDLSNNNIANIND 523
Cdd:COG4886 149 TD--LPEPLGNLTNLKSLDLSNNQLTDL---------------------------PEELGNLTNLKELDLSNNQITDLPE 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  524 DmLEGLEKLEILDLQHNNLARLwkhanPGGpiyfLKGLSHLHILNLESNGFDEIPveVFKDLFELKIIDLGLNNLNTLPA 603
Cdd:COG4886 200 P-LGNLTNLEELDLSGNQLTDL-----PEP----LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP 267

                       330       340
                ....*....|....*....|....*..
gi 4507531  604 SVFNNQvsLKSLNLQKNLITSVEKKVF 630
Cdd:COG4886 268 LANLTN--LKTLDLSNNQLTDLKLKEL 292
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 354-540 3.33e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.87  E-value: 3.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  354 LKCLEHLNMEDNDIPGIKSnmFTGLINLKYLSL-SNSFTSLRTLtnETFVSLAHsplhiLNLTKNKISKIESdaFSWLGH 432
Cdd:cd21340   1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLyDNKITKIENL--EFLTNLTH-----LYLQNNQIEKIEN--LENLVN 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  433 LEVLDLGLNEIgQELTGQEwrGLENIFEIYLSY------NKYLQLTRNSFALVPSLQRLMLRRVALknvdSSPSPFQPLR 506
Cdd:cd21340  70 LKKLYLGGNRI-SVVEGLE--NLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNI----DSLEPLAPLR 142

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 4507531  507 NLTILDLS--NNNIANINDDMLEGLEKLEILDLQHN 540
Cdd:cd21340 143 NLEQLDASnnQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
274-329 5.88e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 5.88e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4507531    274 TNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNL 329
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 37-207 8.43e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 8.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   37 CSHLKLTQVPD-DLPTNITVLNLTHNQLRRLPaaNFTRYSQLTSLDVGFNTISKLEPElcQKLPMLKVLNLQHNELSQLS 115
Cdd:cd21340   9 LNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRISVVE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  116 DktFAFCTNLTELHLMSNSIQKikNNPFVK--------QKNLITLDLSHNGLSStkLGTQVQLENLQELLLSNNKIQALK 187
Cdd:cd21340  85 G--LENLTNLEELHIENQRLPP--GEKLTFdprslaalSNSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLE 158

                       170       180
                ....*....|....*....|
gi 4507531  188 SEELDIFANSSLKKLELSSN 207
Cdd:cd21340 159 ELLDLLSSWPSLRELDLTGN 178
LRRCT smart00082
Leucine rich repeat C-terminal domain;
645-697 4.02e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 4.02e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 4507531     645 NPFDCTCEsIAWFVNWINET-HTNIPElssHYLCNTPPHYHGfPVRLFDTSS--CK 697
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQANeHLQDPV---DLRCASPSSLRG-PLLELLHSEfkCP 51
LRR_8 pfam13855
Leucine rich repeat;
409-467 5.27e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 5.27e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4507531    409 LHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIgQELTGQEWRGLENIFEIYLSYNK 467
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSGLPSLRYLDLSGNR 60
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 616-688 1.62e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 1.62e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4507531     616 NLQKNLITSVEKKVFGPAFrNLTELDMRFNPFDCTCeSIAWFVNWINETHTNI--PELSshyLCNTPPHYHGFPV 688
Cdd:TIGR00864    1 DISNNKISTIEEGICANLC-NLSEIDLSGNPFECDC-GLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPL 70
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 785-880 2.31e-05

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 45.43  E-value: 2.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531    785 KFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCkRFKVHHAVQQAIEQNLdSIILVFLEEIPDYKLNHAL 864
Cdd:pfam01582  30 KLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWC-LDELVKILECALDLGQ-KVIPIFYEVDPSDVRKQTG 107

                          90       100
                  ....*....|....*....|...
gi 4507531    865 CLRRGmFKSHC-------ILNWP 880
Cdd:pfam01582 108 SFGKA-FKKHKkvlteekVLKWR 129
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
457-680 3.69e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.38  E-value: 3.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   457 NIFEIYLSYNkylQLTRNSFALVPSLQRLMLRRVALKNV-DSSPSPFQPLrnltilDLSNNNIANINDDMLEGLEKLEIL 535
Cdd:PRK15370 221 NIKTLYANSN---QLTSIPATLPDTIQEMELSINRITELpERLPSALQSL------DLFHNKISCLPENLPEELRYLSVY 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   536 DlqhNNLARLwkhanpggPIYFLKGLSHlhiLNLESNGFDEIPVEVFKDlfeLKIIDLGLNNLNTLPASVfnnQVSLKSL 615
Cdd:PRK15370 292 D---NSIRTL--------PAHLPSGITH---LNVQSNSLTALPETLPPG---LKTLEAGENALTSLPASL---PPELQVL 351

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4507531   616 NLQKNLITsVEKKVFGPafrNLTELDMRFNPFDCTCESIAWFVNWINETHTN---IPELSSHYLCNTP 680
Cdd:PRK15370 352 DVSKNQIT-VLPETLPP---TITTLDVSRNALTNLPENLPAALQIMQASRNNlvrLPESLPHFRGEGP 415
LRRNT smart00013
Leucine rich repeat N-terminal domain;
28-54 5.68e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.37  E-value: 5.68e-03
                           10        20
                   ....*....|....*....|....*..
gi 4507531      28 CTVSHEVADCSHLKLTQVPDDLPTNIT 54
Cdd:smart00013   6 CNCSGTAVDCSGRGLTEVPLDLPPDTT 32
 
Name Accession Description Interval E-value
TIR smart00255
Toll - interleukin 1 - resistance;
755-900 7.85e-25

Toll - interleukin 1 - resistance;


Pssm-ID: 214587 [Multi-domain]  Cd Length: 140  Bit Score: 100.86  E-value: 7.85e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531     755 EYAAYIIHAYKDkdWVWEHFSSMEKEDQ-SLKFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCkRFKVH 833
Cdd:smart00255   1 EYDVFISYSGKE--DVRNEFLSHLLEKLrGYGLCVFIDDFEPGGGDLEEIDEAIEKSRIAIVVLSPNYAESEWC-LDELV 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4507531     834 HAVQQAIEQNLDSIILVFLEEIPDYKLNHALCLRRGMFKShcILNWPvqKERIGAFRHKLQVALGSK 900
Cdd:smart00255  78 AALENALEEGGLRVIPIFYEVIPSDVRKQPGKFRKVFKKN--YLKWP--EDEKEQFWKKALYAVPSK 140
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-309 1.22e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 86.53  E-value: 1.22e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   36 DCSHLKLTQVPDDLP--TNITVLNLTHNQLRRLPAAnFTRYSQLTSLDVGFNTISKLEPELcQKLPMLKVLNLQHNELSQ 113
Cdd:COG4886 119 DLSGNQLTDLPEELAnlTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDLPEEL-GNLTNLKELDLSNNQITD 196

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  114 LSDkTFAFCTNLTELHLMSNSIQKIkNNPFVKQKNLITLDLSHNGLSS-------TKLgtqvqlenlQELLLSNNKIQAL 186
Cdd:COG4886 197 LPE-PLGNLTNLEELDLSGNQLTDL-PEPLANLTNLETLDLSNNQLTDlpelgnlTNL---------EELDLSNNQLTDL 265

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  187 KSEeldiFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNT 266
Cdd:COG4886 266 PPL----ANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLA 341

                       250       260       270       280
                ....*....|....*....|....*....|....*....|...
gi 4507531  267 TFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNN 309
Cdd:COG4886 342 LSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLAL 384
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-296 1.65e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 79.98  E-value: 1.65e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   36 DCSHLKLTQVPDDLP--TNITVLNLTHNQLRRLPAAnFTRYSQLTSLDVGFNTISKLEPELCQkLPMLKVLNLQHNELSQ 113
Cdd:COG4886 142 DLSNNQLTDLPEPLGnlTNLKSLDLSNNQLTDLPEE-LGNLTNLKELDLSNNQITDLPEPLGN-LTNLEELDLSGNQLTD 219

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  114 LSDkTFAFCTNLTELHLMSNSIQKIKNnpFVKQKNLITLDLSHNGLSStkLGTQVQLENLQELLLSNNKIQALKSEELDI 193
Cdd:COG4886 220 LPE-PLANLTNLETLDLSNNQLTDLPE--LGNLTNLEELDLSNNQLTD--LPPLANLTNLKTLDLSNNQLTDLKLKELEL 294

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  194 FANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKW 273
Cdd:COG4886 295 LLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGL 374

                       250       260
                ....*....|....*....|...
gi 4507531  274 TNLTMLDLSYNNLNVVGNDSFAW 296
Cdd:COG4886 375 LEATLLTLALLLLTLLLLLLTTT 397
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
51-415 6.70e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 6.70e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   51 TNITVLNLTHNQLRRLPAAnFTRYSQLTSLDVGFNTISKLEPELcQKLPMLKVLNLQHNELSQLSDkTFAFCTNLTELHL 130
Cdd:COG4886 113 TNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDLSNNQLTDLPE-ELGNLTNLKELDL 189

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  131 MSNSIQKIKNnPFVKQKNLITLDLSHNGLSStklgtqvqlenlqelllsnnkiqalksEELDIFANSSLKKLELSSNQIK 210
Cdd:COG4886 190 SNNQITDLPE-PLGNLTNLEELDLSGNQLTD---------------------------LPEPLANLTNLETLDLSNNQLT 241

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  211 EFspgcfhaigrlfglflnnvqlgPSLTEklclelaNTSIRNLSLSNSQLSTTSNTtflgLKWTNLTMLDLSYNNLNVVG 290
Cdd:COG4886 242 DL----------------------PELGN-------LTNLEELDLSNNQLTDLPPL----ANLTNLKTLDLSNNQLTDLK 288

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  291 NDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNMEDNDIPGI 370
Cdd:COG4886 289 LKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLT 368

                       330       340       350       360
                ....*....|....*....|....*....|....*....|....*
gi 4507531  371 KSNMFTGLINLKYLSLSNSFTSLRTLTNETFVSLAHSPLHILNLT 415
Cdd:COG4886 369 LGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLLLTLALLDAVNT 413
Tlr3_TMD pfam17968
Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR ...
 698-730 2.25e-13

Toll-like receptor 3 trans-membrane domain; Toll-like receptor (TLR) 3 is an endosomal TLR that mediates immune responses against viral infections upon activation by its ligand double-stranded RNA, a replication intermediate of most viruses. TLR3 is expressed widely in the body and activates both the innate and adaptive immune systems. This entry represents the Toll-like receptor 3 trans-membrane domain which has been shown to form dimers and trimers with different surfaces for helix-helix interaction.


Pssm-ID: 465595  Cd Length: 33  Bit Score: 64.63  E-value: 2.25e-13
                          10        20        30
                  ....*....|....*....|....*....|...
gi 4507531    698 DSAPFELFFMINTSILLIFIFIVLLIHFEGWRI 730
Cdd:pfam17968   1 DSAPFKLLFVISSTAVLLFIFIVLLIHFQGWRI 33
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 72-542 3.18e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 70.65  E-value: 3.18e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531    72 TRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELS-QLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKqkNLI 150
Cdd:PLN00113  66 NNSSRVVSIDLSGKNISGKISSAIFRLPYIQTINLSNNQLSgPIPDDIFTTSSSLRYLNLSNNNFTGSIPRGSIP--NLE 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   151 TLDLSHNGLSStklgtqvqlenlqelllsnnKIQAlkseelDIFANSSLKKLELSSNQIKEFSPGCFHAIGRLFGLFLNN 230
Cdd:PLN00113 144 TLDLSNNMLSG--------------------EIPN------DIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLAS 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   231 VQLgpslTEKLCLELANT-SIRNLSLSNSQLSTTSNTTFLGLkwTNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNN 309
Cdd:PLN00113 198 NQL----VGQIPRELGQMkSLKWIYLGYNNLSGEIPYEIGGL--TSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNK 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   310 IQHLFSHSLHGLFNVRYLNLKRSFTKQSIslaslPKIddfsFQWLKCLEHLNMEDNDIPG----------------IKSN 373
Cdd:PLN00113 272 LSGPIPPSIFSLQKLISLDLSDNSLSGEI-----PEL----VIQLQNLEILHLFSNNFTGkipvaltslprlqvlqLWSN 342

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   374 MFTGLINlKYLSLSNSFTSLRTLTN-------ETFVSLAHSPLHIL--NLTKNKISKIESDAFSwlghLEVLDLGLNEIG 444
Cdd:PLN00113 343 KFSGEIP-KNLGKHNNLTVLDLSTNnltgeipEGLCSSGNLFKLILfsNSLEGEIPKSLGACRS----LRRVRLQDNSFS 417

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   445 QELTgQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRVA-------------LKNVDSS--------PSPFQ 503
Cdd:PLN00113 418 GELP-SEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKffgglpdsfgskrLENLDLSrnqfsgavPRKLG 496

                        490       500       510
                 ....*....|....*....|....*....|....*....
gi 4507531   504 PLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNL 542
Cdd:PLN00113 497 SLSELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQL 535
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-485 9.36e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 68.04  E-value: 9.36e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   98 LPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELL 177
Cdd:COG4886   8 LTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLL 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  178 LSNNKIQALKSEELDIFAN------SSLKKLELSSNQIKEFSPgcfhAIGRLfglflnnvqlgpslteklclelanTSIR 251
Cdd:COG4886  88 GLTDLGDLTNLTELDLSGNeelsnlTNLESLDLSGNQLTDLPE----ELANL------------------------TNLK 139

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  252 NLSLSNSQLstTSNTTFLGlKWTNLTMLDLSYNNLNVVGnDSFAWLPQLEYFFLEYNNIQHLfSHSLHGLFNVRYLNLKR 331
Cdd:COG4886 140 ELDLSNNQL--TDLPEPLG-NLTNLKSLDLSNNQLTDLP-EELGNLTNLKELDLSNNQITDL-PEPLGNLTNLEELDLSG 214

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  332 S-FTKQSISLASLPKiddfsfqwlkcLEHLNMEDNDIPGIKSnmFTGLINLKYLSLSN----SFTSLRTLTNETFVSLAH 406
Cdd:COG4886 215 NqLTDLPEPLANLTN-----------LETLDLSNNQLTDLPE--LGNLTNLEELDLSNnqltDLPPLANLTNLKTLDLSN 281

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  407 SPLHILNLTK-NKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRL 485
Cdd:COG4886 282 NQLTDLKLKElELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSL 361
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
284-630 5.60e-11

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 65.73  E-value: 5.60e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  284 NNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSFTKQSISLASLPKIDDFSFQWLKCLEHLNME 363
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  364 DNDIPGIKSNMFTGLINLKYLSLSNSfTSLRTLTNetfvslahspLHILNLTKNKISKIeSDAFSWLGHLEVLDLGLNEI 443
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGN-EELSNLTN----------LESLDLSGNQLTDL-PEELANLTNLKELDLSNNQL 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  444 GQelTGQEWRGLENIFEIYLSYNKYLQLtrnsfalvpslqrlmlrrvalknvdssPSPFQPLRNLTILDLSNNNIANIND 523
Cdd:COG4886 149 TD--LPEPLGNLTNLKSLDLSNNQLTDL---------------------------PEELGNLTNLKELDLSNNQITDLPE 199

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  524 DmLEGLEKLEILDLQHNNLARLwkhanPGGpiyfLKGLSHLHILNLESNGFDEIPveVFKDLFELKIIDLGLNNLNTLPA 603
Cdd:COG4886 200 P-LGNLTNLEELDLSGNQLTDL-----PEP----LANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPP 267

                       330       340
                ....*....|....*....|....*..
gi 4507531  604 SVFNNQvsLKSLNLQKNLITSVEKKVF 630
Cdd:COG4886 268 LANLTN--LKTLDLSNNQLTDLKLKEL 292
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-478 1.65e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 64.18  E-value: 1.65e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   77 LTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNElsqlsdkTFAFCTNLTELHLMSNSIQKIKNNpFVKQKNLITLDLsh 156
Cdd:COG4886  74 LLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-------ELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDL-- 143

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  157 nglsstklgtqvqlenlqelllSNNKIQALKSEeldIFANSSLKKLELSSNQIKEFSPgcfhAIGRLfglflnnvqlgps 236
Cdd:COG4886 144 ----------------------SNNQLTDLPEP---LGNLTNLKSLDLSNNQLTDLPE----ELGNL------------- 181

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  237 lteklclelanTSIRNLSLSNSQLSTTSNTtfLGlKWTNLTMLDLSYNNLNVVGnDSFAWLPQLEYFFLEYNNIQHLFsh 316
Cdd:COG4886 182 -----------TNLKELDLSNNQITDLPEP--LG-NLTNLEELDLSGNQLTDLP-EPLANLTNLETLDLSNNQLTDLP-- 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  317 SLHGLFNVRYLNLkrSFTKqsisLASLPKIDDfsfqwLKCLEHLNMEDNDIPGIKSNMFTGLINLKYLSLSNSfTSLRTL 396
Cdd:COG4886 245 ELGNLTNLEELDL--SNNQ----LTDLPPLAN-----LTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLL-LLNLLE 312

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  397 TNETFVSLAHSPLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSF 476
Cdd:COG4886 313 LLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALLLLTLLLL 392


                ..
gi 4507531  477 AL 478
Cdd:COG4886 393 LL 394
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
223-622 8.32e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.87  E-value: 8.32e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  223 LFGLFLNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYNNLNVVGNDSFAWLPQLEY 302
Cdd:COG4886  21 LTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTE 100

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  303 FFLEYNNiqhlfshSLHGLFNVRYLNLKRSftkqsiSLASLPKiddfSFQWLKCLEHLNMEDNDIPGIKSNmFTGLINLK 382
Cdd:COG4886 101 LDLSGNE-------ELSNLTNLESLDLSGN------QLTDLPE----ELANLTNLKELDLSNNQLTDLPEP-LGNLTNLK 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  383 YLSLSNsfTSLRTLTNEtFVSLAHspLHILNLTKNKISKIeSDAFSWLGHLEVLDLG---LNEIGQELTGqewrgLENIF 459
Cdd:COG4886 163 SLDLSN--NQLTDLPEE-LGNLTN--LKELDLSNNQITDL-PEPLGNLTNLEELDLSgnqLTDLPEPLAN-----LTNLE 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  460 EIYLSYNKYLQLTrnSFALVPSLQRLMLRRvalkNVDSSPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQH 539
Cdd:COG4886 232 TLDLSNNQLTDLP--ELGNLTNLEELDLSN----NQLTDLPPLANLTNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLL 305

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  540 NNLARLWKHANPGGPIYFLKGLSHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQK 619
Cdd:COG4886 306 LLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLLLTLLLTLGLLGLLEATLLTLALL 385


                ...
gi 4507531  620 NLI 622
Cdd:COG4886 386 LLT 388
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
411-645 1.04e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.49  E-value: 1.04e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  411 ILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIGQELTGQEWRGLENIFEIYLSYNKYLQLTRNSFALVPSLQRLMLRRV 490
Cdd:COG4886   1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  491 ALKNVDSSPSPFQPLRNLTILDLSNNNIaninddmLEGLEKLEILDLQHNNLARLWKhanpggpiyFLKGLSHLHILNLE 570
Cdd:COG4886  81 LLSLLLLGLTDLGDLTNLTELDLSGNEE-------LSNLTNLESLDLSGNQLTDLPE---------ELANLTNLKELDLS 144

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4507531  571 SNGFDEIPvEVFKDLFELKIIDLGLNNLNTLPASVFNNQvSLKSLNLQKNLITSVEKKVFGpaFRNLTELDMRFN 645
Cdd:COG4886 145 NNQLTDLP-EPLGNLTNLKSLDLSNNQLTDLPEELGNLT-NLKELDLSNNQITDLPEPLGN--LTNLEELDLSGN 215
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 354-540 3.33e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 57.87  E-value: 3.33e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  354 LKCLEHLNMEDNDIPGIKSnmFTGLINLKYLSL-SNSFTSLRTLtnETFVSLAHsplhiLNLTKNKISKIESdaFSWLGH 432
Cdd:cd21340   1 LKRITHLYLNDKNITKIDN--LSLCKNLKVLYLyDNKITKIENL--EFLTNLTH-----LYLQNNQIEKIEN--LENLVN 69

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  433 LEVLDLGLNEIgQELTGQEwrGLENIFEIYLSY------NKYLQLTRNSFALVPSLQRLMLRRVALknvdSSPSPFQPLR 506
Cdd:cd21340  70 LKKLYLGGNRI-SVVEGLE--NLTNLEELHIENqrlppgEKLTFDPRSLAALSNSLRVLNISGNNI----DSLEPLAPLR 142

                       170       180       190
                ....*....|....*....|....*....|....*.
gi 4507531  507 NLTILDLS--NNNIANINDDMLEGLEKLEILDLQHN 540
Cdd:cd21340 143 NLEQLDASnnQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
274-329 5.88e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.91  E-value: 5.88e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 4507531    274 TNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNL 329
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDL 56
LRR_8 pfam13855
Leucine rich repeat;
248-310 1.30e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 51.76  E-value: 1.30e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4507531    248 TSIRNLSLSNSQLSTTSNTTFLGLKwtNLTMLDLSYNNLNVVGNDSFAWLPQLEYFFLEYNNI 310
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLS--NLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
75-135 5.07e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 5.07e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507531     75 SQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSI 135
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 37-207 8.43e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 53.64  E-value: 8.43e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   37 CSHLKLTQVPD-DLPTNITVLNLTHNQLRRLPaaNFTRYSQLTSLDVGFNTISKLEPElcQKLPMLKVLNLQHNELSQLS 115
Cdd:cd21340   9 LNDKNITKIDNlSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQIEKIENL--ENLVNLKKLYLGGNRISVVE 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  116 DktFAFCTNLTELHLMSNSIQKikNNPFVK--------QKNLITLDLSHNGLSStkLGTQVQLENLQELLLSNNKIQALK 187
Cdd:cd21340  85 G--LENLTNLEELHIENQRLPP--GEKLTFdprslaalSNSLRVLNISGNNIDS--LEPLAPLRNLEQLDASNNQISDLE 158

                       170       180
                ....*....|....*....|
gi 4507531  188 SEELDIFANSSLKKLELSSN 207
Cdd:cd21340 159 ELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
51-111 1.74e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 48.67  E-value: 1.74e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507531     51 TNITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNEL 111
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRCT smart00082
Leucine rich repeat C-terminal domain;
645-697 4.02e-07

Leucine rich repeat C-terminal domain;


Pssm-ID: 214507 [Multi-domain]  Cd Length: 51  Bit Score: 47.42  E-value: 4.02e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 4507531     645 NPFDCTCEsIAWFVNWINET-HTNIPElssHYLCNTPPHYHGfPVRLFDTSS--CK 697
Cdd:smart00082   1 NPFICDCE-LRWLLRWLQANeHLQDPV---DLRCASPSSLRG-PLLELLHSEfkCP 51
LRR_8 pfam13855
Leucine rich repeat;
409-467 5.27e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.52  E-value: 5.27e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4507531    409 LHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEIgQELTGQEWRGLENIFEIYLSYNK 467
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL-TTLSPGAFSGLPSLRYLDLSGNR 60
LRR_8 pfam13855
Leucine rich repeat;
562-622 5.76e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.13  E-value: 5.76e-07
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507531    562 SHLHILNLESNGFDEIPVEVFKDLFELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLI 622
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
40-209 5.94e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 5.94e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531    40 LKLTQVPDDLPTNITVLNLTHNQLRRLPA---AN----FTRYSQLTSLDVGF-NTISKLE------PELCQKLP-MLKVL 104
Cdd:PRK15370 188 LGLTTIPACIPEQITTLILDNNELKSLPEnlqGNiktlYANSNQLTSIPATLpDTIQEMElsinriTELPERLPsALQSL 267

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   105 NLQHNELSQLSD------KTFAFCTN------------LTELHLMSNSIQKIknnPFVKQKNLITLDLSHNGLSSTKlgt 166
Cdd:PRK15370 268 DLFHNKISCLPEnlpeelRYLSVYDNsirtlpahlpsgITHLNVQSNSLTAL---PETLPPGLKTLEAGENALTSLP--- 341

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 4507531   167 QVQLENLQELLLSNNKIQALKS------EELDIFAN----------SSLKKLELSSNQI 209
Cdd:PRK15370 342 ASLPPELQVLDVSKNQITVLPEtlpptiTTLDVSRNaltnlpenlpAALQIMQASRNNL 400
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 531-647 1.44e-06

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 51.20  E-value: 1.44e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  531 KLEILDLQHNNL----ARLWKHAnpggpiyfLKGLSHLHILNLESNGFDEIPV----EVFKDLFELKIIDLGLNNLNTLP 602
Cdd:cd00116 166 DLKELNLANNGIgdagIRALAEG--------LKANCNLEVLDLNNNGLTDEGAsalaETLASLKSLEVLNLGDNNLTDAG 237

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|...
gi 4507531  603 ASVFNNQV-----SLKSLNLQKNLITSVEKKVFG---PAFRNLTELDMRFNPF 647
Cdd:cd00116 238 AAALASALlspniSLLTLSLSCNDITDDGAKDLAevlAEKESLLELDLRGNKF 290
PCC TIGR00864
polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) ...
 616-688 1.62e-06

polycystin cation channel protein; The Polycystin Cation Channel (PCC) Family (TC 1.A.5) Polycystin is a huge protein of 4303aas. Its repeated leucine-rich (LRR) segment is found in many proteins. It contains 16 polycystic kidney disease (PKD) domains, one LDL-receptor class A domain, one C-type lectin family domain, and 16-18 putative TMSs in positions between residues 2200 and 4100. Polycystin-L has been shown to be a cation (Na+, K+ and Ca2+) channel that is activated by Ca2+. Two members of the PCC family (polycystin 1 and 2) are mutated in autosomal dominant polycystic kidney disease, and polycystin-L is deleted in mice with renal and retinal defects. Note: this model is restricted to the amino half.


Pssm-ID: 188093 [Multi-domain]  Cd Length: 2740  Bit Score: 52.39  E-value: 1.62e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4507531     616 NLQKNLITSVEKKVFGPAFrNLTELDMRFNPFDCTCeSIAWFVNWINETHTNI--PELSshyLCNTPPHYHGFPV 688
Cdd:TIGR00864    1 DISNNKISTIEEGICANLC-NLSEIDLSGNPFECDC-GLARLPRWAEEKGVKVrqPEAA---LCAGPGALAGQPL 70
LRR_8 pfam13855
Leucine rich repeat;
101-159 4.84e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.82  E-value: 4.84e-06
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4507531    101 LKVLNLQHNELSQLSDKTFAFCTNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGL 159
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 55-310 5.68e-06

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 50.23  E-value: 5.68e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531    55 VLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPE-LCQKLPMLKVLnLQHNELSQLSDKTFAFCTNLTELHLMSN 133
Cdd:PLN00113 336 VLQLWSNKFSGEIPKNLGKHNNLTVLDLSTNNLTGEIPEgLCSSGNLFKLI-LFSNSLEGEIPKSLGACRSLRRVRLQDN 414

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   134 SIQKIKNNPFVKQKNLITLDLSHNGLSSTKLGTQVQLENLQELLLSNNKIqalkSEEL-DIFANSSLKKLELSSNQIKEf 212
Cdd:PLN00113 415 SFSGELPSEFTKLPLVYFLDISNNNLQGRINSRKWDMPSLQMLSLARNKF----FGGLpDSFGSKRLENLDLSRNQFSG- 489

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   213 spgcfhAIGRLFGlflnnvqlgpSLTEklclelantsIRNLSLSNSQLSTTSNTTFLGLKwtNLTMLDLSYNNLNVVGND 292
Cdd:PLN00113 490 ------AVPRKLG----------SLSE----------LMQLKLSENKLSGEIPDELSSCK--KLVSLDLSHNQLSGQIPA 541

                        250
                 ....*....|....*...
gi 4507531   293 SFAWLPQLEYFFLEYNNI 310
Cdd:PLN00113 542 SFSEMPVLSQLDLSQNQL 559
LRR_8 pfam13855
Leucine rich repeat;
587-647 7.16e-06

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 44.05  E-value: 7.16e-06
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507531    587 ELKIIDLGLNNLNTLPASVFNNQVSLKSLNLQKNLITSVEKKVFGPaFRNLTELDMRFNPF 647
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSG-LPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
36-161 1.36e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 48.92  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531    36 DCSHLKLTQVPDDLPTNITVLNLTHNQLRRLPAAnftRYSQLTSLDVGFNTISKLePElcqKLPM-LKVLNLQHNELSQL 114
Cdd:PRK15370 268 DLFHNKISCLPENLPEELRYLSVYDNSIRTLPAH---LPSGITHLNVQSNSLTAL-PE---TLPPgLKTLEAGENALTSL 340

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 4507531   115 SDKTfafctnLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSS 161
Cdd:PRK15370 341 PASL------PPELQVLDVSKNQITVLPETLPPTITTLDVSRNALTN 381
TIR pfam01582
TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular ...
 785-880 2.31e-05

TIR domain; The Toll/interleukin-1 receptor (TIR) homology domain is an intracellular signalling domain found in MyD88, interleukin 1 receptor and the Toll receptor. It contains three highly-conserved regions, and mediates protein-protein interactions between the Toll-like receptors (TLRs) and signal-transduction components. TIR-like motifs are also found in plant proteins thought to be involved in resistance to disease. When activated, TIR domains recruit cytoplasmic adaptor proteins MyD88 and TOLLIP (Toll interacting protein). In turn, these associate with various kinases to set off signalling cascades.


Pssm-ID: 396246 [Multi-domain]  Cd Length: 165  Bit Score: 45.43  E-value: 2.31e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531    785 KFCLEERDFEAGVFELEAIVNSIKRSRKIIFVITHHLLKDPLCkRFKVHHAVQQAIEQNLdSIILVFLEEIPDYKLNHAL 864
Cdd:pfam01582  30 KLFIDDRDLEPGEAIAPELLSAIEKSRRSVVVLSPNYASSGWC-LDELVKILECALDLGQ-KVIPIFYEVDPSDVRKQTG 107

                          90       100
                  ....*....|....*....|...
gi 4507531    865 CLRRGmFKSHC-------ILNWP 880
Cdd:pfam01582 108 SFGKA-FKKHKkvlteekVLKWR 129
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
457-680 3.69e-05

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 47.38  E-value: 3.69e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   457 NIFEIYLSYNkylQLTRNSFALVPSLQRLMLRRVALKNV-DSSPSPFQPLrnltilDLSNNNIANINDDMLEGLEKLEIL 535
Cdd:PRK15370 221 NIKTLYANSN---QLTSIPATLPDTIQEMELSINRITELpERLPSALQSL------DLFHNKISCLPENLPEELRYLSVY 291

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   536 DlqhNNLARLwkhanpggPIYFLKGLSHlhiLNLESNGFDEIPVEVFKDlfeLKIIDLGLNNLNTLPASVfnnQVSLKSL 615
Cdd:PRK15370 292 D---NSIRTL--------PAHLPSGITH---LNVQSNSLTALPETLPPG---LKTLEAGENALTSLPASL---PPELQVL 351

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4507531   616 NLQKNLITsVEKKVFGPafrNLTELDMRFNPFDCTCESIAWFVNWINETHTN---IPELSSHYLCNTP 680
Cdd:PRK15370 352 DVSKNQIT-VLPETLPP---TITTLDVSRNALTNLPENLPAALQIMQASRNNlvrLPESLPHFRGEGP 415
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 50-161 8.96e-05

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 45.94  E-value: 8.96e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   50 PTNITVLNLTHNQLR----RLPAANFTRYSQLTSLDVGFNTIS-----KLEPELcQKLPMLKVLNLQHNELS----QLSD 116
Cdd:COG5238 263 NTTVETLYLSGNQIGaegaIALAKALQGNTTLTSLDLSVNRIGdegaiALAEGL-QGNKTLHTLNLAYNGIGaqgaIALA 341

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....
gi 4507531  117 KTFAFCTNLTELHLMSNSI---------QKIKNNPfvkqkNLITLDLSHNGLSS 161
Cdd:COG5238 342 KALQENTTLHSLDLSDNQIgdegaialaKYLEGNT-----TLRELNLGKNNIGK 390
LRR_8 pfam13855
Leucine rich repeat;
480-542 1.60e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 1.60e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4507531    480 PSLQRLMLRRVALKNVDssPSPFQPLRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNL 542
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLD--DGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 216-620 3.63e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 44.45  E-value: 3.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   216 CFHAIGRLFGLFLNnvqLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSNT--TFLGLKWTN---LTMLDLSYNNLNVVG 290
Cdd:PLN00113   9 CPYLIFMLFFLFLN---FSMLHAEELELLLSFKSSINDPLKYLSNWNSSADvcLWQGITCNNssrVVSIDLSGKNISGKI 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   291 NDSFAWLPQLEYFFLEYNNIQHLFSHSLHGL-FNVRYLNLKRSFTKQSISLASLPkiddfsfqwlkCLEHLNMEDNdipg 369
Cdd:PLN00113  86 SSAIFRLPYIQTINLSNNQLSGPIPDDIFTTsSSLRYLNLSNNNFTGSIPRGSIP-----------NLETLDLSNN---- 150

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   370 iksnMFTGLINLKYlslsNSFTSLRTLTNETFVSLAHSPLHILNLTKNKISKIESDAF-----SWLGHLEVLD---LGLN 441
Cdd:PLN00113 151 ----MLSGEIPNDI----GSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLvgqipRELGQMKSLKwiyLGYN 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   442 EIGQELTgQEWRGLENIFEIYLSYN----------------KYLQLTRNSFA-LVP----SLQRLmlrrVALKNVDSSPS 500
Cdd:PLN00113 223 NLSGEIP-YEIGGLTSLNHLDLVYNnltgpipsslgnlknlQYLFLYQNKLSgPIPpsifSLQKL----ISLDLSDNSLS 297

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531   501 PFQP-----LRNLTILDLSNNNIANINDDMLEGLEKLEILDLQHNNL-----ARLWKHANpggpiyflkglshLHILNLE 570
Cdd:PLN00113 298 GEIPelviqLQNLEILHLFSNNFTGKIPVALTSLPRLQVLQLWSNKFsgeipKNLGKHNN-------------LTVLDLS 364

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4507531   571 SNGFD-EIPVEVFKDLFELKIIdLGLNNLNT-LPASVFNNQvSLKSLNLQKN 620
Cdd:PLN00113 365 TNNLTgEIPEGLCSSGNLFKLI-LFSNSLEGeIPKSLGACR-SLRRVRLQDN 414
PLN03150 PLN03150
hypothetical protein; Provisional
 44-112 5.62e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 43.65  E-value: 5.62e-04
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507531    44 QVPDDLPT--NITVLNLTHNQLRRLPAANFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELS 112
Cdd:PLN03150 433 FIPNDISKlrHLQSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLS 503
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 48-160 6.41e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 43.68  E-value: 6.41e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531    48 DLPTnITVLNLTHNQ-LRRLPaaNFTRYSQLTSLDVGFNTISKLEPELCQKLPMLKVLNLQHNELSQLSDKTFAFCTNLT 126
Cdd:PLN00113 450 DMPS-LQMLSLARNKfFGGLP--DSFGSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGEIPDELSSCKKLV 526

                         90       100       110
                 ....*....|....*....|....*....|....
gi 4507531   127 ELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLS 160
Cdd:PLN00113 527 SLDLSHNQLSGQIPASFSEMPVLSQLDLSQNQLS 560
LRR_8 pfam13855
Leucine rich repeat;
380-443 8.58e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 8.58e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4507531    380 NLKYLSLSNSftSLRTLTNETFVSLAHspLHILNLTKNKISKIESDAFSWLGHLEVLDLGLNEI 443
Cdd:pfam13855   2 NLRSLDLSNN--RLTSLDDGAFKGLSN--LKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
298-367 9.47e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 38.27  E-value: 9.47e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531    298 PQLEYFFLEYNNIQHLFSHSLHGLFNVRYLNLKRSftkqsislaSLPKIDDFSFQWLKCLEHLNMEDNDI 367
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNN---------LLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 104-284 1.05e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 41.31  E-value: 1.05e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  104 LNLQHNELSQLSDktFAFCTNLTELHLMSNSIQKIKNnpFVKQKNLITLDLSHN------GLSS----TKLgtqvqlenl 173
Cdd:cd21340   7 LYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNqiekieNLENlvnlKKL--------- 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  174 qelLLSNNKIQALksEELDifansSLKKLE--------LSSNQIKEFSPGCFHAIG---RLFGLFLNNVQlgpSLTEKLC 242
Cdd:cd21340  74 ---YLGGNRISVV--EGLE-----NLTNLEelhienqrLPPGEKLTFDPRSLAALSnslRVLNISGNNID---SLEPLAP 140

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 4507531  243 LelanTSIRNLSLSNSQLSTTSNTTFLGLKWTNLTMLDLSYN 284
Cdd:cd21340 141 L----RNLEQLDASNNQISDLEELLDLLSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
123-161 2.44e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 37.12  E-value: 2.44e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4507531    123 TNLTELHLMSNSIQKIKNNPFVKQKNLITLDLSHNGLSS 161
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTT 39
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 28-50 4.00e-03

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 35.68  E-value: 4.00e-03
                          10        20
                  ....*....|....*....|...
gi 4507531     28 CTVSHEVADCSHLKLTQVPDDLP 50
Cdd:pfam01462   6 CHCSATVVNCSDRGLTAVPRDLP 28
LRRNT smart00013
Leucine rich repeat N-terminal domain;
28-54 5.68e-03

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 35.37  E-value: 5.68e-03
                           10        20
                   ....*....|....*....|....*..
gi 4507531      28 CTVSHEVADCSHLKLTQVPDDLPTNIT 54
Cdd:smart00013   6 CNCSGTAVDCSGRGLTEVPLDLPPDTT 32
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 195-451 7.64e-03

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 39.65  E-value: 7.64e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  195 ANSSLKKLELSSNQIKEFSPG---CFHAIGRLFGLF---LNNVQLGPSLTEKLCLELANTSIRNLSLSNSQLSTTSnTTF 268
Cdd:cd00116  49 PQPSLKELCLSLNETGRIPRGlqsLLQGLTKGCGLQeldLSDNALGPDGCGVLESLLRSSSLQELKLNNNGLGDRG-LRL 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  269 L--GLK--WTNLTMLDLSYNNLNVVGNDSFA----WLPQLEYFFLEYNNIQH-LFSHSLHGL---FNVRYLNLKRSF--T 334
Cdd:cd00116 128 LakGLKdlPPALEKLVLGRNRLEGASCEALAkalrANRDLKELNLANNGIGDaGIRALAEGLkanCNLEVLDLNNNGltD 207

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507531  335 KQSISLASLPKIddfsfqwLKCLEHLNMEDN-----DIPGIKSNMFTGLINLKYLSLSNSftslrTLTNETFVSLAHSpl 409
Cdd:cd00116 208 EGASALAETLAS-------LKSLEVLNLGDNnltdaGAAALASALLSPNISLLTLSLSCN-----DITDDGAKDLAEV-- 273

                       250       260       270       280
                ....*....|....*....|....*....|....*....|..
gi 4507531  410 hilnltknkISKIESdafswlghLEVLDLGLNEIGQELTGQE 451
Cdd:cd00116 274 ---------LAEKES--------LLELDLRGNKFGEEGAQLL 298
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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