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Conserved domains on  [gi|4507703|ref|NP_003301|]
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EARP and GARP complex-interacting protein 1 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 1000017)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-370 3.72e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 3.72e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  139 CVVWEPmgDGKKIISL-ADNHILLWDLQESSSQavlassASLEGKgQLKFTSGRWSPHHNctQVATA-NDTTLRGWDTRS 216
Cdd:cd00200  14 CVAFSP--DGKLLATGsGDGTIKVWDLETGELL------RTLKGH-TGPVRDVAASADGT--YLASGsSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  217 MSQIYCIEnAHGQLVRDLDFNPNKQyYLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNVRYNHShDQLVLTGSSDSR 296
Cdd:cd00200  83 GECVRTLT-GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGT 158

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4507703  297 VILSNMVSISsepfghlvddddisdqedhrseekskeplqdnVIATYEEHEDSVYAVDWSSADPWLFASlSYDG 370
Cdd:cd00200 159 IKLWDLRTGK--------------------------------CVATLTGHTGEVNSVAFSPDGEKLLSS-SSDG 199
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-370 3.72e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 3.72e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  139 CVVWEPmgDGKKIISL-ADNHILLWDLQESSSQavlassASLEGKgQLKFTSGRWSPHHNctQVATA-NDTTLRGWDTRS 216
Cdd:cd00200  14 CVAFSP--DGKLLATGsGDGTIKVWDLETGELL------RTLKGH-TGPVRDVAASADGT--YLASGsSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  217 MSQIYCIEnAHGQLVRDLDFNPNKQyYLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNVRYNHShDQLVLTGSSDSR 296
Cdd:cd00200  83 GECVRTLT-GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGT 158

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4507703  297 VILSNMVSISsepfghlvddddisdqedhrseekskeplqdnVIATYEEHEDSVYAVDWSSADPWLFASlSYDG 370
Cdd:cd00200 159 IKLWDLRTGK--------------------------------CVATLTGHTGEVNSVAFSPDGEKLLSS-SSDG 199
WD40 COG2319
WD40 repeat [General function prediction only];
39-299 2.27e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 2.27e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703   39 YDNQIHIIDFDDENNIinkNVLLHQAGEIWHISASPADRGVLTTCYNRTsdskvltcAAVW-----RMPKELESGSHE-- 111
Cdd:COG2319 140 ADGTVRLWDLATGKLL---RTLTGHSGAVTSVAFSPDGKLLASGSDDGT--------VRLWdlatgKLLRTLTGHTGAvr 208

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  112 ----SPDD----SSSTAQTLEL------LCHLDNTAHGNMA-CVVWEPmgDGKKIISL-ADNHILLWDLQESSSQAVLAS 175
Cdd:COG2319 209 svafSPDGkllaSGSADGTVRLwdlatgKLLRTLTGHSGSVrSVAFSP--DGRLLASGsADGTVRLWDLATGELLRTLTG 286

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  176 SASlegkgqlKFTSGRWSPhhNCTQVATA-NDTTLRGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVK 254
Cdd:COG2319 287 HSG-------GVNSVAFSP--DGKLLASGsDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKT-LASGSDDGTVR 355

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4507703  255 FWDTRNvTEPVKTLEEHSHWVWNVRYnhSHD-QLVLTGSSDSRVIL 299
Cdd:COG2319 356 LWDLAT-GELLRTLTGHTGAVTSVAF--SPDgRTLASGSADGTVRL 398
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-257 3.19e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.19e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 4507703     225 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
225-257 1.00e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.00e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 4507703    225 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 204-281 2.12e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703   204 ANDTTLRGWDTR----SMSQI---YCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTL--EEHSHW 274
Cdd:PTZ00420  94 SEDLTIRVWEIPhndeSVKEIkdpQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINmpKKLSSL 173


                 ....*..
gi 4507703   275 VWNVRYN 281
Cdd:PTZ00420 174 KWNIKGN 180
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 139-370 3.72e-20

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 89.70  E-value: 3.72e-20
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  139 CVVWEPmgDGKKIISL-ADNHILLWDLQESSSQavlassASLEGKgQLKFTSGRWSPHHNctQVATA-NDTTLRGWDTRS 216
Cdd:cd00200  14 CVAFSP--DGKLLATGsGDGTIKVWDLETGELL------RTLKGH-TGPVRDVAASADGT--YLASGsSDKTIRLWDLET 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  217 MSQIYCIEnAHGQLVRDLDFNPNKQyYLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNVRYNHShDQLVLTGSSDSR 296
Cdd:cd00200  83 GECVRTLT-GHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET-GKCLTTLRGHTDWVNSVAFSPD-GTFVASSSQDGT 158

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4507703  297 VILSNMVSISsepfghlvddddisdqedhrseekskeplqdnVIATYEEHEDSVYAVDWSSADPWLFASlSYDG 370
Cdd:cd00200 159 IKLWDLRTGK--------------------------------CVATLTGHTGEVNSVAFSPDGEKLLSS-SSDG 199
WD40 COG2319
WD40 repeat [General function prediction only];
39-299 2.27e-15

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 76.87  E-value: 2.27e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703   39 YDNQIHIIDFDDENNIinkNVLLHQAGEIWHISASPADRGVLTTCYNRTsdskvltcAAVW-----RMPKELESGSHE-- 111
Cdd:COG2319 140 ADGTVRLWDLATGKLL---RTLTGHSGAVTSVAFSPDGKLLASGSDDGT--------VRLWdlatgKLLRTLTGHTGAvr 208

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  112 ----SPDD----SSSTAQTLEL------LCHLDNTAHGNMA-CVVWEPmgDGKKIISL-ADNHILLWDLQESSSQAVLAS 175
Cdd:COG2319 209 svafSPDGkllaSGSADGTVRLwdlatgKLLRTLTGHSGSVrSVAFSP--DGRLLASGsADGTVRLWDLATGELLRTLTG 286

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  176 SASlegkgqlKFTSGRWSPhhNCTQVATA-NDTTLRGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVK 254
Cdd:COG2319 287 HSG-------GVNSVAFSP--DGKLLASGsDDGTVRLWDLATGKLLRTLT-GHTGAVRSVAFSPDGKT-LASGSDDGTVR 355

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*.
gi 4507703  255 FWDTRNvTEPVKTLEEHSHWVWNVRYnhSHD-QLVLTGSSDSRVIL 299
Cdd:COG2319 356 LWDLAT-GELLRTLTGHTGAVTSVAF--SPDgRTLASGSADGTVRL 398
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 39-299 3.32e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.45  E-value: 3.32e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703   39 YDNQIHIIDFddENNIINKNVLLHqAGEIWHISASPADRGVLTTCYNRTS---DSKVLTCAAVWRMPKELESGSHESPDD 115
Cdd:cd00200  29 GDGTIKVWDL--ETGELLRTLKGH-TGPVRDVAASADGTYLASGSSDKTIrlwDLETGECVRTLTGHTSYVSSVAFSPDG 105

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  116 ----SSSTAQTL------------ELLCHLDNTAhgnmaCVVWEPmgdGKKII--SLADNHILLWDLQESSSQAVLA--- 174
Cdd:cd00200 106 rilsSSSRDKTIkvwdvetgkcltTLRGHTDWVN-----SVAFSP---DGTFVasSSQDGTIKLWDLRTGKCVATLTght 177

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  175 ---SSASLEGKGQlKFtsgrwsphhnctqVATANDTTLRGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKqYYLASCGDDC 251
Cdd:cd00200 178 gevNSVAFSPDGE-KL-------------LSSSSDGTIKLWDLSTGKCLGTLR-GHENGVNSVAFSPDG-YLLASGSEDG 241

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*...
gi 4507703  252 KVKFWDTRNvTEPVKTLEEHSHWVWNVRYnHSHDQLVLTGSSDSRVIL 299
Cdd:cd00200 242 TIRVWDLRT-GECVQTLSGHTNSVTSLAW-SPDGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
112-374 1.58e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 71.48  E-value: 1.58e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  112 SPDDSSSTAQTLELLCHLDNTAHGNMACVVWEPMGDGKKIISLADNHILLWDLQESSSQAVLASSASLegkgqlkFTSGR 191
Cdd:COG2319  13 SADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAA-------VLSVA 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  192 WSPHHNcTQVATANDTTLRGWDTRSmSQIYCIENAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEH 271
Cdd:COG2319  86 FSPDGR-LLASASADGTVRLWDLAT-GLLLRTLTGHTGAVRSVAFSPDGKT-LASGSADGTVRLWDLAT-GKLLRTLTGH 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  272 SHWVWNVRYnhSHD-QLVLTGSSDSRVILSNMVSissepfghlvddddisdqedhrseekskeplqDNVIATYEEHEDSV 350
Cdd:COG2319 162 SGAVTSVAF--SPDgKLLASGSDDGTVRLWDLAT--------------------------------GKLLRTLTGHTGAV 207

                       250       260
                ....*....|....*....|....
gi 4507703  351 YAVDWsSADPWLFASLSYDGRLVI 374
Cdd:COG2319 208 RSVAF-SPDGKLLASGSADGTVRL 230
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 227-374 6.85e-12

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 65.43  E-value: 6.85e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  227 HGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRNvTEPVKTLEEHSHWVWNVRYnHSHDQLVLTGSSDSRVILSNMVSis 306
Cdd:cd00200   8 HTGGVTCVAFSPDGKL-LATGSGDGTIKVWDLET-GELLRTLKGHTGPVRDVAA-SADGTYLASGSSDKTIRLWDLET-- 82

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4507703  307 sepfghlvddddisdqedhrseekskeplqDNVIATYEEHEDSVYAVDWSSADPWLFASlSYDGRLVI 374
Cdd:cd00200  83 ------------------------------GECVRTLTGHTSYVSSVAFSPDGRILSSS-SRDKTIKV 119
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 132-257 5.76e-10

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 59.66  E-value: 5.76e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  132 TAH-GNMACVVWEPmgDGKKIISLA-DNHILLWDLQESssqavlASSASLEGKGQlKFTSGRWSPHHNcTQVATANDTTL 209
Cdd:cd00200 174 TGHtGEVNSVAFSP--DGEKLLSSSsDGTIKLWDLSTG------KCLGTLRGHEN-GVNSVAFSPDGY-LLASGSEDGTI 243

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 4507703  210 RGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:cd00200 244 RVWDLRTGECVQTLS-GHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
39-260 1.07e-07

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 53.38  E-value: 1.07e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703   39 YDNQIHIIDFDDENNIInknVLLHQAGEIWHISASPADRGVLTTCYNRTsdskvltcAAVWRMpkelesgshespddssS 118
Cdd:COG2319 224 ADGTVRLWDLATGKLLR---TLTGHSGSVRSVAFSPDGRLLASGSADGT--------VRLWDL----------------A 276

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703  119 TAQTLELLCHLDNTAHGnmacVVWEPmgDGKKIISL-ADNHILLWDLQESSSQAVLASSASlegkgqlKFTSGRWSPhhN 197
Cdd:COG2319 277 TGELLRTLTGHSGGVNS----VAFSP--DGKLLASGsDDGTVRLWDLATGKLLRTLTGHTG-------AVRSVAFSP--D 341

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4507703  198 CTQVATA-NDTTLRGWDTRSMSQIYCIEnAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWDTRN 260
Cdd:COG2319 342 GKTLASGsDDGTVRLWDLATGELLRTLT-GHTGAVTSVAFSPDGRT-LASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 225-257 3.19e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 3.19e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 4507703     225 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
225-257 1.00e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 1.00e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 4507703    225 NAHGQLVRDLDFNPNKQYyLASCGDDCKVKFWD 257
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 204-281 2.12e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 39.93  E-value: 2.12e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507703   204 ANDTTLRGWDTR----SMSQI---YCIENAHGQLVRDLDFNPNKQYYLASCGDDCKVKFWDTRNVTEPVKTL--EEHSHW 274
Cdd:PTZ00420  94 SEDLTIRVWEIPhndeSVKEIkdpQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWDIENEKRAFQINmpKKLSSL 173


                 ....*..
gi 4507703   275 VWNVRYN 281
Cdd:PTZ00420 174 KWNIKGN 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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