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Conserved domains on  [gi|238859545|ref|NP_003314|]
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tubby-related protein 2 [Homo sapiens]

Protein Classification

tubby family protein( domain architecture ID 11242254)

tubby (TUB) family protein similar to Mus musculus tubby protein that binds to membranes containing phosphatidylinositol 4,5-bisphosphate and functions in signal transduction from heterotrimeric G protein-coupled receptors

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
Tub pfam01167
Tub family;
277-519 9.85e-120

Tub family;


:

Pssm-ID: 460094  Cd Length: 251  Bit Score: 351.88  E-value: 9.85e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545  277 LRPALPGTMMQCYLTRDKHGVdkGLFPLYYLYLETSD-SLQRFLLAGRKRRRSKTSNYLISLDPTHLSRDGDNFVGKVRS 355
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPgDGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545  356 NVFSTKFTIFDN-----GVNPDREHLTRNTARI---RQELGAVCYEPNVLGYLGPRKMTVILPGTNSQNQRINVQPLNEQ 427
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKVspgRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545  428 eSLLSRYQRGDKQGLLLLHNKTPSWDKENGVYTLNFHGRVTRASVKNFQIVDPKHQEHLVLQFGRVGPDTFTMDFCFPFS 507
Cdd:pfam01167 159 -SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237

                         250
                  ....*....|..
gi 238859545  508 PLQAFSICLSSF 519
Cdd:pfam01167 238 AFQAFAICLSSF 249
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 27-250 3.15e-43

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


:

Pssm-ID: 465092  Cd Length: 196  Bit Score: 152.27  E-value: 3.15e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545   27 QQRRLFEKKQRQKRQELLMVQANPDASPWLWRSCLREE-------RLLGDRGLGNPfLRKKVSEAHLPSGIHSALGTvsC 99
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEqaplvesYLSGNSGTIYH-VQEAAPRSAKRSGAHAALGT--Q 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545  100 GGDGRGERGLPTPRTEAvfrnlglqspflswlPDNSDAELEEVSVENGSVSPPPFKQsprirrkgwqaHQRPGTRAEGES 179
Cdd:pfam16322  78 GGDGKGIDGPAAFLTEE---------------PQDSGSELQILSVGDSPTSPPPDEE-----------LQEPGASGEEES 131

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238859545  180 DSQDMGDAHKSPnmGPNPGMDGdcvyenlafqkeeDLEKKREASESTGTNSSAAHNEELSKALKGEGGTDS 250
Cdd:pfam16322 132 SKQDLGDEMQKK--GISSSMNF-------------DEEEEDEEEESSSRSSQLNSNEESTRPSSATSKKSS 187
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
277-519 9.85e-120

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 351.88  E-value: 9.85e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545  277 LRPALPGTMMQCYLTRDKHGVdkGLFPLYYLYLETSD-SLQRFLLAGRKRRRSKTSNYLISLDPTHLSRDGDNFVGKVRS 355
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPgDGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545  356 NVFSTKFTIFDN-----GVNPDREHLTRNTARI---RQELGAVCYEPNVLGYLGPRKMTVILPGTNSQNQRINVQPLNEQ 427
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKVspgRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545  428 eSLLSRYQRGDKQGLLLLHNKTPSWDKENGVYTLNFHGRVTRASVKNFQIVDPKHQEHLVLQFGRVGPDTFTMDFCFPFS 507
Cdd:pfam01167 159 -SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237

                         250
                  ....*....|..
gi 238859545  508 PLQAFSICLSSF 519
Cdd:pfam01167 238 AFQAFAICLSSF 249
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 27-250 3.15e-43

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 152.27  E-value: 3.15e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545   27 QQRRLFEKKQRQKRQELLMVQANPDASPWLWRSCLREE-------RLLGDRGLGNPfLRKKVSEAHLPSGIHSALGTvsC 99
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEqaplvesYLSGNSGTIYH-VQEAAPRSAKRSGAHAALGT--Q 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545  100 GGDGRGERGLPTPRTEAvfrnlglqspflswlPDNSDAELEEVSVENGSVSPPPFKQsprirrkgwqaHQRPGTRAEGES 179
Cdd:pfam16322  78 GGDGKGIDGPAAFLTEE---------------PQDSGSELQILSVGDSPTSPPPDEE-----------LQEPGASGEEES 131

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238859545  180 DSQDMGDAHKSPnmGPNPGMDGdcvyenlafqkeeDLEKKREASESTGTNSSAAHNEELSKALKGEGGTDS 250
Cdd:pfam16322 132 SKQDLGDEMQKK--GISSSMNF-------------DEEEEDEEEESSSRSSQLNSNEESTRPSSATSKKSS 187
 
Name Accession Description Interval E-value
Tub pfam01167
Tub family;
277-519 9.85e-120

Tub family;


Pssm-ID: 460094  Cd Length: 251  Bit Score: 351.88  E-value: 9.85e-120
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545  277 LRPALPGTMMQCYLTRDKHGVdkGLFPLYYLYLETSD-SLQRFLLAGRKRRRSKTSNYLISLDPTHLSRDGDNFVGKVRS 355
Cdd:pfam01167   1 KQPGPRDGTIQCFIKRDKSGM--GLTPTYHLYLELSPgDGGKFLLAARKRRRSTTSNYLISLDADDLSRGSNGYIGKLRS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545  356 NVFSTKFTIFDN-----GVNPDREHLTRNTARI---RQELGAVCYEPNVLGYLGPRKMTVILPGTNSQNQRINVQPLNEQ 427
Cdd:pfam01167  79 NFLGTKFTLYDNqppynGANPSKSRSSFGSKKVspgRYELAAVSYELNVLGTRGPRRMKVIIPSIPASGQQVPIQPQSES 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545  428 eSLLSRYQRGDKQGLLLLHNKTPSWDKENGVYTLNFHGRVTRASVKNFQIVDPKHQEHLVLQFGRVGPDTFTMDFCFPFS 507
Cdd:pfam01167 159 -SLLEDFKSGRLDELLVLKNKPPRWNEQLQCYCLNFHGRVTVASVKNFQLVAPEDQDKVILQFGKVGKDMFTMDYRYPLS 237

                         250
                  ....*....|..
gi 238859545  508 PLQAFSICLSSF 519
Cdd:pfam01167 238 AFQAFAICLSSF 249
Tub_N pfam16322
Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear ...
 27-250 3.15e-43

Tubby N-terminal; Tub_N is the N-terminal region of Tubby proteins. It carries a nuclear localization signal and is able to activate transcription.


Pssm-ID: 465092  Cd Length: 196  Bit Score: 152.27  E-value: 3.15e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545   27 QQRRLFEKKQRQKRQELLMVQANPDASPWLWRSCLREE-------RLLGDRGLGNPfLRKKVSEAHLPSGIHSALGTvsC 99
Cdd:pfam16322   1 RQRALLEKKQRKKRQEPLMVQANPDARLRRRRPRRSEEqaplvesYLSGNSGTIYH-VQEAAPRSAKRSGAHAALGT--Q 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 238859545  100 GGDGRGERGLPTPRTEAvfrnlglqspflswlPDNSDAELEEVSVENGSVSPPPFKQsprirrkgwqaHQRPGTRAEGES 179
Cdd:pfam16322  78 GGDGKGIDGPAAFLTEE---------------PQDSGSELQILSVGDSPTSPPPDEE-----------LQEPGASGEEES 131

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 238859545  180 DSQDMGDAHKSPnmGPNPGMDGdcvyenlafqkeeDLEKKREASESTGTNSSAAHNEELSKALKGEGGTDS 250
Cdd:pfam16322 132 SKQDLGDEMQKK--GISSSMNF-------------DEEEEDEEEESSSRSSQLNSNEESTRPSSATSKKSS 187
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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