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Conserved domains on  [gi|4507803|ref|NP_003344|]
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urocortin preproprotein [Homo sapiens]

Protein Classification

corticotropin-releasing factor family protein( domain architecture ID 10452639)

corticotropin-releasing factor (CRF) family protein such as human corticoliberin, a peptide hormone, whose interaction with its type 1 receptor (CRFR1), a class B G-protein-coupled receptor (GPCR), is crucial for activation of the hypothalamic-pituitary-adrenal axis in response to stress

Gene Ontology:  GO:0005179
PubMed:  30109816|16472809

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CRF pfam00473
Corticotropin-releasing factor family;
85-122 2.46e-14

Corticotropin-releasing factor family;


:

Pssm-ID: 425703  Cd Length: 38  Bit Score: 61.70  E-value: 2.46e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4507803     85 PSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV 122
Cdd:pfam00473   1 PSLSIDLPFHVLRQLLMLAKARRQREQAAANRKILDEV 38
 
Name Accession Description Interval E-value
CRF pfam00473
Corticotropin-releasing factor family;
85-122 2.46e-14

Corticotropin-releasing factor family;


Pssm-ID: 425703  Cd Length: 38  Bit Score: 61.70  E-value: 2.46e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4507803     85 PSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV 122
Cdd:pfam00473   1 PSLSIDLPFHVLRQLLMLAKARRQREQAAANRKILDEV 38
CRF smart00039
corticotropin-releasing factor;
83-122 9.85e-11

corticotropin-releasing factor;


Pssm-ID: 128354  Cd Length: 40  Bit Score: 52.79  E-value: 9.85e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4507803      83 DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV 122
Cdd:smart00039   1 EGPSLSIDLTFDLLRQRLELEKAERRREQAQANRNFLDDV 40
 
Name Accession Description Interval E-value
CRF pfam00473
Corticotropin-releasing factor family;
85-122 2.46e-14

Corticotropin-releasing factor family;


Pssm-ID: 425703  Cd Length: 38  Bit Score: 61.70  E-value: 2.46e-14
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4507803     85 PSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV 122
Cdd:pfam00473   1 PSLSIDLPFHVLRQLLMLAKARRQREQAAANRKILDEV 38
CRF smart00039
corticotropin-releasing factor;
83-122 9.85e-11

corticotropin-releasing factor;


Pssm-ID: 128354  Cd Length: 40  Bit Score: 52.79  E-value: 9.85e-11
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4507803      83 DNPSLSIDLTFHLLRTLLELARTQSQRERAEQNRIIFDSV 122
Cdd:smart00039   1 EGPSLSIDLTFDLLRQRLELEKAERRREQAQANRNFLDDV 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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