NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|17017976|ref|NP_003387|]
View 

protein Wnt-9b isoform 1 precursor [Homo sapiens]

Protein Classification

wnt family protein( domain architecture ID 14443642)

wnt family protein function in both normal development and differentiation as well as in mammary tumorigenesis

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 60-356 0e+00

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


:

Pssm-ID: 381728  Cd Length: 297  Bit Score: 591.87  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLYAVSSAALTHTLARACSAGR 139
Cdd:cd19354   1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGRGSLLKRGFKETAFLYAVSSAALTHSLAKACSSGR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 140 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 219
Cdd:cd19354  81 MERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSC 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 220 AVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPG 299
Cdd:cd19354 161 AVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFCRPSKYSPG 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17017976 300 TAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19354 241 TAGRTCSRETNCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
 
Name Accession Description Interval E-value
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 60-356 0e+00

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 591.87  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLYAVSSAALTHTLARACSAGR 139
Cdd:cd19354   1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGRGSLLKRGFKETAFLYAVSSAALTHSLAKACSSGR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 140 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 219
Cdd:cd19354  81 MERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSC 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 220 AVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPG 299
Cdd:cd19354 161 AVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFCRPSKYSPG 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17017976 300 TAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19354 241 TAGRTCSRETNCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 57-356 2.79e-136

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 389.99  E-value: 2.79e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976    57 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGR----MGLLKRGFKETAFLYAVSSAALTHTL 131
Cdd:pfam00110   2 LPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCStLENKrpvfGKVLKRGTRETAFVYAISSAGVTHAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976   132 ARACSAGRMERCTCDDSPGLES--RQAWQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRT 208
Cdd:pfam00110  82 TRACSSGELTSCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVDAReKKRRDARALMNLHNNEAGRKAVKSNMRT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976   209 TCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEAlGRLELWAPARQgsltkglAPRSGDLVYMEDSP 288
Cdd:pfam00110 162 ECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRNKR-GRLVPRNSRFK-------PPTKNDLVYLEKSP 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17017976   289 SFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:pfam00110 234 DYCERNPKtgSLGTRGRECNKTSsgpdGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
WNT1 smart00097
found in Wnt-1;
57-356 2.90e-100

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 298.46  E-value: 2.90e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976     57 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGRM---GLLKRGFKETAFLYAVSSAALTHTLA 132
Cdd:smart00097   2 LPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCStLDNASvfgKVLRQGTRETAFVYAISSAGVAHAVT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976    133 RACSAGRMERCTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCK 211
Cdd:smart00097  82 RACSEGELDSCGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRECK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976    212 CHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVssatnEALGRLELWAPARQGSLTKglAPRSGDLVYMEDSPSFC 291
Cdd:smart00097 162 CHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEV-----EVDKRGTNKAPVPKNSTFK--PPTETDLVYLESSPDFC 234

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17017976    292 R--PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:smart00097 235 EknPKTGSLGTQGRQCNKTSkgldGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
 
Name Accession Description Interval E-value
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 60-356 0e+00

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 591.87  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKRGFKETAFLYAVSSAALTHTLARACSAGR 139
Cdd:cd19354   1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGRGSLLKRGFKETAFLYAVSSAALTHSLAKACSSGR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 140 MERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSC 219
Cdd:cd19354  81 MERCTCDDSPGLENREAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCHGVSGSC 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 220 AVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYSPG 299
Cdd:cd19354 161 AVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERHGHTLKGHSPRSTDLVYLEDSPSFCRPSKYSPG 240

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17017976 300 TAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19354 241 TAGRTCSRETNCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 60-356 1.43e-164

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 461.37  E-value: 1.43e-164
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLE-GRMGLLKRGFKETAFLYAVSSAALTHTLARACSAG 138
Cdd:cd19341   1 LSRRQRRMCRRDPGLAETLLEAIRLSVLECQEQFRYERWNCSLGkYRINLLKKGYKETAFLYAISSAGLTHSVARACSSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 139 RMERCTCDDSPGLE-SRQAWQWGVCGDNLKYSTKFLSNFLGSKRGN-KDLRARADAHNTHVGIKAVKSGLRTTCKCHGVS 216
Cdd:cd19341  81 RLDRCTCDESFSLEeNRQTWLWGGCGDNIKYGKKFTRRFLQLKKKSgKDLRAEIDRHNSEVGIRVVREGVKKTCKCHGVS 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 217 GSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELwAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKY 296
Cdd:cd19341 161 GSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVVSENNAATGGSQL-RKGKSGSVKKKSRPRRKDLVYLEKSPSFCRSTRY 239

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 297 SPGTAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19341 240 SPGTKGRRCLKGDNCDTLCCGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTCK 299
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 60-356 1.81e-151

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 428.30  E-value: 1.81e-151
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGR--MGLLKRGFKETAFLYAVSSAALTHTLARACSA 137
Cdd:cd19353   1 LERKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRyrASLLKRGFKETAFLYAISSAGLTHAMAKACSA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 138 GRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGsKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSG 217
Cdd:cd19353  81 GRMERCTCDEAPDLENREAWQWGGCGDNLKYSNKFVKEFLG-RKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCHGVSG 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 218 SCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRPSKYS 297
Cdd:cd19353 160 SCTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGDISPPKKSGAGHSDQIPRTTDLVYIDDSPSFCLMSRFS 239

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17017976 298 PGTAGRVCSREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19353 240 PGTSGRRCYKDKNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 57-356 2.79e-136

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 389.99  E-value: 2.79e-136
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976    57 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGR----MGLLKRGFKETAFLYAVSSAALTHTL 131
Cdd:pfam00110   2 LPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCStLENKrpvfGKVLKRGTRETAFVYAISSAGVTHAV 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976   132 ARACSAGRMERCTCDDSPGLES--RQAWQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRT 208
Cdd:pfam00110  82 TRACSSGELTSCGCDRKKRGKSsgEGGWEWGGCSDNIDYGYKFSRKFVDAReKKRRDARALMNLHNNEAGRKAVKSNMRT 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976   209 TCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEAlGRLELWAPARQgsltkglAPRSGDLVYMEDSP 288
Cdd:pfam00110 162 ECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKVNRRRNKR-GRLVPRNSRFK-------PPTKNDLVYLEKSP 233

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17017976   289 SFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:pfam00110 234 DYCERNPKtgSLGTRGRECNKTSsgpdGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 74-355 1.25e-108

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 319.24  E-value: 1.25e-108
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  74 LAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGL----LKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDSP 149
Cdd:cd13113   1 LMESIAEGAQLALKECQRQFANRRWNCSTFNEPLLfgkiLKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRTR 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 150 -GLESRQAWQWGVCGDNLKYSTKFLSNFL--GSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWK 226
Cdd:cd13113  81 qGPEGQGDWTWGGCSDNIKFGIKFSRKFLdaREKKKGSDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTCWR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 227 QLSPFRETGQVLKLRYDSAVKVSSATNealGRLELWAPARQGSLTkglaPRSGDLVYMEDSPSFCRP--SKYSPGTAGRV 304
Cdd:cd13113 161 QLPSFREIGDYLKEKYDNAVKVKLNNN---GSGLRLVPKRSRFRS----PTETDLVYLEESPDYCEPnpTLGSLGTAGRE 233

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17017976 305 CSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTC 355
Cdd:cd13113 234 CNPTSpgpdSCELLCCGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 60-356 5.45e-107

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 316.13  E-value: 5.45e-107
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGR------MGLLKRGFKETAFLYAVSSAALTHTLA 132
Cdd:cd19342  10 LTREQLELCRRYPDVTASAIQGIQLAVHECQRQFRDHRWNCSsLETKnknphtSPILSRGYRETAFAYAISAAGVAHQVA 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 133 RACSAGRMERCTCDDS--PGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTC 210
Cdd:cd19342  90 RACSLGKLLSCGCDRSrrGKRSSGNDWKWGGCSHNLDFGEKFSRKFLDSREKARDIHSRMNLHNNRAGRLAVSENMERKC 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 211 KCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSaTNEALGRLELWAPARQGSLTkglaPRSGDLVYMEDSPSF 290
Cdd:cd19342 170 KCHGMSGSCELKTCWKAAPDFREVGDILKEKYDHATLVDQ-SNLNNGARRRRLTRRKRRRR----PPKTDLVYYERSPNF 244

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17017976 291 CRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19342 245 CEADPSldSPGTRGRVCNKTStgpdSCDSLCCGRGYNTVRQTRTERCNCRFHWCCYVVCEKCTETEWVTVCK 316
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 59-356 3.46e-105

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 311.08  E-value: 3.46e-105
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  59 KLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRM--GLLKRGFKETAFLYAVSSAALTHTLARACS 136
Cdd:cd19338  12 RLKGKQREICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCSTSRKSfgKILKRDTRETAFVYAITSAGVTYSVTRACS 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 137 AGRMERCTCDDSPGLESRQ-AWQWGVCGDNLKYSTKFLSNFL-GSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHG 214
Cdd:cd19338  92 MGELLQCGCDKSKRGKSTEgEWEWGGCSDNVRYGYRKSREFMdAKEKNRSDIRTLMNLHNNEAGRLAVKNNMRKECKCHG 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 215 VSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSsatnealgrlelwaPARQGsltKGLAPRS--------GDLVYMED 286
Cdd:cd19338 172 LSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKVK--------------GSNDG---KSLIPEGktikpptkEDLVYLEE 234

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17017976 287 SPSFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19338 235 SPDFCEPNKKtgSLGTRGRECNRTSmgvdGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTCN 310
WNT1 smart00097
found in Wnt-1;
57-356 2.90e-100

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 298.46  E-value: 2.90e-100
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976     57 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGRM---GLLKRGFKETAFLYAVSSAALTHTLA 132
Cdd:smart00097   2 LPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCStLDNASvfgKVLRQGTRETAFVYAISSAGVAHAVT 81

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976    133 RACSAGRMERCTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCK 211
Cdd:smart00097  82 RACSEGELDSCGCDYRKrGRAGGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRECK 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976    212 CHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVssatnEALGRLELWAPARQGSLTKglAPRSGDLVYMEDSPSFC 291
Cdd:smart00097 162 CHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEV-----EVDKRGTNKAPVPKNSTFK--PPTETDLVYLESSPDFC 234

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 17017976    292 R--PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:smart00097 235 EknPKTGSLGTQGRQCNKTSkgldGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 60-356 1.06e-99

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 297.22  E-value: 1.06e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRM----GLLKRGFKETAFLYAVSSAALTHTLARAC 135
Cdd:cd19344   1 LVSQQRRLCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCSTTNDQnvfgKTLSRGTKETAFIYAITSAGVVHAVTRAC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 136 SAGRMERCTCDDSP-GLESRQAWQWGVCGDNLKYSTKFLSNFL-----GSKRGNKDLRARADAHNTHVGIKAVKSGLRTT 209
Cdd:cd19344  81 SAGNLTDCSCDSRRqGQSASEGWKWGGCSDNVDYGIWFARKFVdapekSERKRSRDVRSLMNLHNNEVGRQAIARLMKVK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 210 CKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVssATNEALGRLElwapaRQGSLTKGLAPRSGDLVYMEDSPS 289
Cdd:cd19344 161 CRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENSIQI--ATKKSKRRLR-----RRERRKRKVPISKDELVYIHKSPN 233

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17017976 290 FCR--PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQ-SRLVAfSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19344 234 YCVrdPKKGILGTSGRECNRTStgpdSCDLLCCGRGYNTQvVRHVE-RCNCKFVWCCYVKCKTCETMTDVHTCK 306
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 60-356 1.83e-98

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 294.24  E-value: 1.83e-98
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMG-----LLKRGFKETAFLYAVSSAALTHTLARA 134
Cdd:cd19334  12 LVSKQRQLCRKHPDVMVSIGEGAKLGVKECQYQFRNQRWNCSTVDRDAtvfgkVLLKGSREAAFVYAISSAGVVHAITRA 91

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 135 CSAGRMERCTCDDSP---GLESRQAWQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRTTC 210
Cdd:cd19334  92 CSKGELLNCACDPTKrgkGRDSKGEFDWGGCSDNVKYGINFARKFVDAReRRVRDARALMNLHNNRAGRKAVKKNLKLQC 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 211 KCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNealGRLELWAPARQGSLTKglaprsGDLVYMEDSPSF 290
Cdd:cd19334 172 KCHGVSGSCTIRTCWRALAEFREVGDYLREKYDGAVQVTMNQS---GTNLLAANKGHKKPTR------SDLVYFESSPDY 242

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17017976 291 CRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19334 243 CVPNPEtgSLGTAGRVCNKTStgtdGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTCK 314
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 55-356 6.35e-95

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 285.29  E-value: 6.35e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  55 CDLLK-LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKR----GFKETAFLYAVSSAALTH 129
Cdd:cd19337   1 CDQLRgLSPGQRKLCQLYQDHMPSVGRGAKLAIEECQYQFRYRRWNCSTPDSSSVFGPvtniGTREAAFTYAISAAGVVH 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 130 TLARACSAGRMERCTCDDSPGLES-RQAWQWGVCGDNLKYSTKFLSNFLGS-------KRGNKDL-RARADAHNTHVGIK 200
Cdd:cd19337  81 AIARACREGNLSTCGCSRERRPKDlPRDWLWGGCGDNIEYGYKFAKEFIDAreretnyPRHSRELaRVLMNLHNNEAGRR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 201 AVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATneaLGRLELwapARQGSLTKglaPRSGD 280
Cdd:cd19337 161 AVYEKARVACKCHGVSGSCSLKTCWRQLAPFREVGDRLKDKYDGAVKVKLNR---RGTLLR---RRNSRFNK---PTKDD 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 281 LVYMEDSPSFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYT 354
Cdd:cd19337 232 LVYLDDSPDYCERNPKtgSLGTKGRECNKTSsgtdGCELLCCGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIVDVHI 311


                ..
gi 17017976 355 CK 356
Cdd:cd19337 312 CK 313
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 60-356 1.45e-94

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 283.76  E-value: 1.45e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS---LEGRMGL-LKRGFKETAFLYAVSSAALTHTLARAC 135
Cdd:cd19343   1 LVGDQVKLCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCSsieLAPNFTPdLTRGTREQAFVYALSSAALTHTIARAC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 136 SAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFL-GSKRGNKDLRARADA----HNTHVGIKAVKSGLRTTC 210
Cdd:cd19343  81 ASGALPGCGCGRLPREPPDGDFKWGGCGDNVRYGLRFAKRFTdAPEKKKKKKKRQARAlmnlHNNRVGRKAVRDSLETQC 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 211 KCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEalGRLELWAPARQGSLTkglapRSGDLVYMEDSPSF 290
Cdd:cd19343 161 KCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVG--SRRKLVPKSLKVRPY-----TKDDLIYLTKSPDY 233

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17017976 291 CRPSKY--SPGTAGRVC----SREASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19343 234 CLPDEKlgSLGTRGRECnktsVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 60-355 2.42e-92

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 278.47  E-value: 2.42e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMG-------LLKRGFKETAFLYAVSSAALTHTLA 132
Cdd:cd19333   1 LTKKQRRLVRQNPGTLHAIARGARMAIKECKWQFRNRRWNCPTTDSRGgpnvfgkILNRGCRETAFIYAITSAAVTHSVA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 133 RACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKC 212
Cdd:cd19333  81 RACSEGSIESCSCDYRRRGPGGPDWEWGGCSDNIDFGRKFSREFVDAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQECKC 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 213 HGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATN--------EALGRLELWAPARQgsltkglAPRSGDLVYM 284
Cdd:cd19333 161 HGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAYGNNgnnrgsrrAKKFLLEPENPNHK-------PPTSKDLVYF 233

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 17017976 285 EDSPSFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTC 355
Cdd:cd19333 234 EESPNFCEKNPKlgTLGTRGRECNATSigldGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTC 310
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 55-356 2.99e-92

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 278.43  E-value: 2.99e-92
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  55 CDLLK-LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRM----GLLKRGFKETAFLYAVSSAALTH 129
Cdd:cd19336   1 CESLKgLTKRQVQFCKRNLEVMDSVRRGAQLAIEECQFQFRNRRWNCSTLDKEpvfgKVLNQGTREAAFVHAISSAGVAH 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 130 TLARACSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGS----KRGNKDLRARADAHNTHVGIKAVKSG 205
Cdd:cd19336  81 AVTRACSSGELEKCGCDRSVRGRSPEGFQWSGCSDNVAYGVAFSKSFVDArerrKGRASSSRALMNLHNNEAGRKAIEKN 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 206 LRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVssatnealgrlelwAPARQGSlTKGLAPR-------- 277
Cdd:cd19336 161 MRVECKCHGVSGSCELKTCWRAMPTFREVGNILKEKFDGATEV--------------QQKRIGS-RPVLVPKnpqfkpht 225

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 278 SGDLVYMEDSPSFCR--PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEEL 351
Cdd:cd19336 226 DADLVYLDSSPDFCEpdPKTGSLGTHGRVCNKTSkaidGCDLLCCGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVE 305


                ....*
gi 17017976 352 VYTCK 356
Cdd:cd19336 306 VHTCR 310
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 60-356 3.54e-90

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 273.01  E-value: 3.54e-90
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGR----MGLLKRGFKETAFLYAVSSAALTHTLARAC 135
Cdd:cd19339   8 LTPRQRAICQSRPDAIVAIGEGAQLGIEECQFQFRNHRWNCTLLGErtvfGQELPVGSREAAFTYAITSAGVAYAITQAC 87

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 136 SAGRMERCTCD--DSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCH 213
Cdd:cd19339  88 SQGNLSDCGCDksKKGYGKSDEGWKWGGCSADVKYGLRFSRKFVDAREVKRNARSLMNLHNNEAGRKAVEENLKLECKCH 167

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 214 GVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKglaPRSGDLVYMEDSPSFCR- 292
Cdd:cd19339 168 GVSGSCTTKTCWTTLPSFREIGDYLKKKYERARRVEPVRGRRRRRPTFLKLKISRKYKK---PRPRDLVYLEKSPNYCEk 244

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17017976 293 -PSKYSPGTAGRVCSR----EASCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19339 245 dPLTGSLGTVGRRCNRtstgTDGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYTCK 313
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 60-356 2.20e-85

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 260.79  E-value: 2.20e-85
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGRMGL----LKRGFKETAFLYAVSSAALTHTLARA 134
Cdd:cd19335  10 LVPKQLRFCRNYTELMPSVAEGAKLGIQECQHQFRGRRWNCTtIEGDLSVfgpvLDKASRESAFVHAIASAGVAHAVTRA 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 135 CSAGRMERCTCDDSPGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHG 214
Cdd:cd19335  90 CAEGDSTSCGCDSRHKGPPGEGWRWGGCSEDVEFGVRFSREFADARENRPDARSAMNRHNNEAGRQAILDNMELKCKCHG 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 215 VSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVK-VSSATNEALGRLELWAParqgSLTKGLAPRSGDLVYMEDSPSFCR- 292
Cdd:cd19335 170 LSGSCELKTCWWAQPDFRKIGDYLKDKYDSASEmVVERHRESRGWVETLRP----KYKLFKPPTERDLIYYEESPNFCEp 245

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17017976 293 -PSKYSPGTAGRVCSREAS----CSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19335 246 nPETGSFGTRGRECNVTSHgidgCDLLCCGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTCK 314
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 74-355 2.38e-81

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 249.90  E-value: 2.38e-81
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  74 LAETLRDAAHLGLLECQFQFRHERWNCSLEGRM--GLLKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDS-PG 150
Cdd:cd19340   9 LSDSVAAGAQLAMEECQYQFKWDRWNCPESAFFsqKNNPSATRETAFVHAISSAGVMYTLTRNCSLGHFEGCGCDDSkKG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 151 LESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSP 230
Cdd:cd19340  89 SKGGEGWTWGGCSDNVKFGERVSKKFLDSLETGQDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGSCSTQTCWMQLAP 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 231 FRETGQVLKLRYDSAVKVSSATnealGRLELWAPARQgslTKGLAPRSGDLVYMEDSPSFCRPSKY--SPGTAGRVCSR- 307
Cdd:cd19340 169 FREIGTDLKRKYDRAVRVDYEN----GGLRETNGSRA---IKLLNIKKNDLVYLEKSPNYCRANVTlgWPGTLGRQCSRd 241

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 17017976 308 ---------EASCSSLCCGRGYDTQSR--LVAFSCHCQVQWCCYVECQQCVQEELVYTC 355
Cdd:cd19340 242 kkesvsrweRKSCRRLCRACGLKVRKKvvEVTSSCNCKFHWCCEVKCETCVELVIEYTC 300
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 60-356 5.51e-74

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 231.73  E-value: 5.51e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-------LEGRMGLlkRGFKETAFLYAVSSAALTHTLA 132
Cdd:cd19346  12 LVNKQRQLCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCStldrdhtVFGRVML--RSSREAAFVYAISSAGVVYAIT 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 133 RACSAGRMERCTCDDSPGLES---RQAWQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRT 208
Cdd:cd19346  90 RACSQGELKSCSCDPHKRGRShdeRGEFDWGGCSDNINYGIKFAKAFVDAKeKKEKDARALMNLHNNRCGRMAVKRFMKL 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 209 TCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVsSATNEALGrlelWAPARQGSltkgLAPRSGDLVYMEDSP 288
Cdd:cd19346 170 ECKCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQV-TMNQDGTG----FTVANKNF----RKATKTDLVYFENSP 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17017976 289 SFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19346 241 DYCVMDKSagSLGTAGRVCNKSSrgtdGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTCK 314
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 60-356 9.05e-74

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 231.48  E-value: 9.05e-74
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGL----LKRGFKETAFLYAVSSAALTHTLARAC 135
Cdd:cd19349  13 LAPRQRAICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNCSALGERTVfgkeLKVGSREAAFTYAIIAAGVAHAITAAC 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 136 SAGRMERCTCDDSP--GLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCH 213
Cdd:cd19349  93 TQGNLSDCGCDKEKqgQYNQEEGWKWGGCSADIRYGIGFSKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCH 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 214 GVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLELWAPARQGSLTKglaPRSGDLVYMEDSPSFCR- 292
Cdd:cd19349 173 GVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRK---PMDTDLVYIEKSPNYCEe 249

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17017976 293 -PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19349 250 dPVTGSVGTQGRMCNKTAqqnnGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTCK 318
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 60-356 1.83e-73

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 230.21  E-value: 1.83e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNC-------SLEGRmgLLKRGFKETAFLYAVSSAALTHTLA 132
Cdd:cd19345  12 LVSRQRQLCHRHPEVMQAIGSGVKEWIAECQHQFRNHRWNCntldrdhSLFGR--LLLRSSRESAFVYAISSAGVVFAIT 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 133 RACSAGRMERCTCDDSPGLESRQA---WQWGVCGDNLKYSTKFLSNFLGSK-RGNKDLRARADAHNTHVGIKAVKSGLRT 208
Cdd:cd19345  90 RACSQGELKSCSCDPKKKGSSKDSkgsFDWGGCSDNIDYGIRFARAFVDAKeRKGKDARALMNLHNNRAGRKAVKRFMTL 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 209 TCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVsSATNEALGRLELWAPARQgsltkglaPRSGDLVYMEDSP 288
Cdd:cd19345 170 ECKCHGVSGSCTVRTCWLAMADFRKTGDYLRKKYNGAIQV-VMNQDGTGFTVANKHFKK--------PTKNDLVYFENSP 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17017976 289 SFCRPSKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19345 241 DYCVRDRDagSLGTAGRVCNRTSrgmdGCEVMCCGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTCK 314
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 60-356 9.12e-71

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 222.93  E-value: 9.12e-71
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LEGRMGL------LKRGFKETAFLYAVSSAALTHTLA 132
Cdd:cd19355  10 LTRRQLEVCMRHPDVTASAIQGIQIAIHECQHQFRDHRWNCSsLETRNKIpyesvvFSRGFRESAFAYAIAAAGVVHAVS 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 133 RACSAGRMERCTCDdspglesrqaWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKC 212
Cdd:cd19355  90 NACAMGKLKACGCD----------WEWGGCSPDVEYGERFSKDFLDSRETYRDIHARMRLHNNRVGRQVVMDNMRRKCKC 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 213 HGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVsSATNEALGRLElwaparQGSLTKGLAPRSGDLVYMEDSPSFCR 292
Cdd:cd19355 160 HGTSGSCQLKTCWQVTPEFRTVGSLLKDRFYVATLI-KPHNRNTGQLE------PGHAPHRRRASINDLVYFEKSPDFCE 232

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 293 --PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19355 233 rePRLDSAGTQGRICNKTSpgmdNCESLCCGRGHNILRQTRSERCNCKFHWCCYVVCEECRITEWVSVCK 302
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 60-356 2.93e-68

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 217.18  E-value: 2.93e-68
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGL----LKRGFKETAFLYAVSSAALTHTLARAC 135
Cdd:cd19350  13 LAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRYGRWNCSALGERTVfgqeLRVGSREAAFTYAITAAGVAHAVTAAC 92

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 136 SAGRMERCTCDDSPG--LESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCH 213
Cdd:cd19350  93 SQGNLSNCGCDREKQgyYNQEEGWKWGGCSADIKYGIDFSRKFVDAREIKKNARRLMNLHNNEAGRKVLEERMKLECKCH 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 214 GVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEalgRLELWAPARQGSLTKGLAPRSGDLVYMEDSPSFCRP 293
Cdd:cd19350 173 GVSGSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVEVVRAS---RLRQPTFLKIKKRRSYQKPMETDLVYIERSPNYCEE 249

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17017976 294 SKY--SPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19350 250 DAAtgSVGTQGRLCNRTSphtdGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 318
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 60-356 1.42e-67

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 214.75  E-value: 1.42e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  60 LSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCS-LE--GRM----GLLKRGFKETAFLYAVSSAALTHTLA 132
Cdd:cd19356  10 LSKRQMGLCVRSPDVTASALQGIQIAIHECQHQLRDQRWNCSsLEggGKLphdsAILKRGFRESAFSFSLLAAGVMHSVA 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 133 RACSAGRMERCTCddspglesrqAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKC 212
Cdd:cd19356  90 TACSLGKLRGCGC----------EWEWGGCSHDIEFGEKFSRDFLDSRESPRDIQARMRIHNNRVGRQVVTENMKRKCKC 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 213 HGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEAlgrlelwaparqGSLTKGLAPR--SGDLVYMEDSPSF 290
Cdd:cd19356 160 HGTSGSCQFKTCWHVTPEFRLVGALLREKFQRAIFINSHNKNS------------GVFLPRLRPRrlARELVYFEKSPDF 227

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17017976 291 CR--PSKYSPGTAGRVCSREA----SCSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19356 228 CErdPAVDSPGTQGRICNKTSpgmdGCGSLCCGRGHNILKQTRSERCHCRFHWCCYVLCEECRVTEWVNVCK 299
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 57-356 7.26e-67

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 213.39  E-value: 7.26e-67
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  57 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKR----GFKETAFLYAVSSAALTHTLA 132
Cdd:cd19347   4 LAGLSQGQKKLCQLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRvmqiGSRETAFTYAISAAGVVNAVS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 133 RACSAGRMERCTCDDSPGLESRQA-WQWGVCGDNLKYSTKFLSNFLGSKRGNK--------DLRARADAHNTHVGIKAVK 203
Cdd:cd19347  84 RACREGELSTCGCSRAARPKDLPRdWLWGGCGDNLEYGYRFAKEFVDAREREKiyqkgsyeSARTLMNLHNNEAGRRTVY 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 204 SGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNEALGRLElwaparqgslTKGLAPRSGDLVY 283
Cdd:cd19347 164 NLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMKLNSRGKLVQVN----------SRFNPPTTLDLVY 233

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17017976 284 MEDSPSFC--RPSKYSPGTAGRVCSREAS----CSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19347 234 IDPSPDYCvrNESTGSLGTQGRLCNKTSEgmdgCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 57-356 6.94e-61

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 197.90  E-value: 6.94e-61
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  57 LLKLSRRQKQLCRREPGLAETLRDAAHLGLLECQFQFRHERWNCSLEGRMGLLKR----GFKETAFLYAVSSAALTHTLA 132
Cdd:cd19348   4 LTGLSPGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTVDNTSVFGRvmqiGSRETAFTYAVSAAGVVNAIS 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 133 RACSAGRMERCTCDDSPGLES-RQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDL--------RARADAHNTHVGIKAVK 203
Cdd:cd19348  84 RACREGELSTCGCSRAARPKDlPRDWLWGGCGDNVEYGYRFAKEFVDAREREKNYpkgseehaRTLMNLQNNEAGRRAVY 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 204 SGLRTTCKCHGVSGSCAVRTCWKQLSPFRETGQVLKLRYDSAVKVSSATNealGRLELWAparqgslTKGLAPRSGDLVY 283
Cdd:cd19348 164 NLADVACKCHGVSGSCSLKTCWLQLADFRKVGDLLKEKYDSAAAMRINRK---GKLELVN-------SRFNPPTAEDLVY 233

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17017976 284 MEDSPSFC--RPSKYSPGTAGRVCSREAS----CSSLCCGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTCK 356
Cdd:cd19348 234 IDPSPDYClrNETTGSLGTQGRLCNKTSEgmdgCELMCCGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEIVDQFVCK 312
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 75-355 3.83e-57

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 188.19  E-value: 3.83e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  75 AETLRDAAHLGLLECQFQFRHERWNCSlEGRMGL-----LKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDS- 148
Cdd:cd19351  10 SSSVAAGAQSGIEECKHQFAWERWNCP-ESALQLsthngLRSATRETSFVHAISSAGVMYTLTRNCSLGDFENCGCDDSr 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 149 PGLESRQAWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQL 228
Cdd:cd19351  89 NGRTGGRGWIWGGCSDNVEFGERISKQFVDALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCSIQTCWLQL 168

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 229 SPFRETGQVLKLRYDSAVKVS------SATNEALGRlelWAPARQGSltkglAPRSGDLVYMEDSPSFC--RPSKYSPGT 300
Cdd:cd19351 169 ADFREIGNYLKVKHDQALKLEmdkrrmRAGNSADNR---GAIAEAFG-----SVAETELIYLEDSPDYCtkNASLGLQGT 240

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17017976 301 AGRVCSREA---------SCSSLC--CGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTC 355
Cdd:cd19351 241 EGRECLQSGknlsqwerrSCRRLCteCGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYC 306
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 81-355 4.21e-57

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 187.92  E-value: 4.21e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976  81 AAHLGLLECQFQFRHERWNCSLEG----RMGLLKRGFKETAFLYAVSSAALTHTLARACSAGRMERCTCDDS-PGLESRQ 155
Cdd:cd19352  17 GAQSGIEECKYQFAWDRWNCPERAlqlsSHSGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSrNGQLGGQ 96

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 156 AWQWGVCGDNLKYSTKFLSNFLGSKRGNKDLRARADAHNTHVGIKAVKSGLRTTCKCHGVSGSCAVRTCWKQLSPFRETG 235
Cdd:cd19352  97 GWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEFREVG 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17017976 236 QVLKLRYDSAVKVS---SATNEALGRlelwaparqGSLTKGLAPRS-GDLVYMEDSPSFCRPSKY--SPGTAGRVCSREA 309
Cdd:cd19352 177 NYLKEKYHRALKVDllqGAGNSAASR---------GAIAETFRSISkKELVHLEDSPDYCLENKTlgLLGTEGRECLKRG 247

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 17017976 310 ---------SCSSLC--CGRGYDTQSRLVAFSCHCQVQWCCYVECQQCVQEELVYTC 355
Cdd:cd19352 248 kalskwekrSCRRLCgdCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFC 304
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH