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Conserved domains on  [gi|4505971|ref|NP_003618|]
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large neutral amino acids transporter small subunit 3 [Homo sapiens]

Protein Classification

sugar MFS transporter( domain architecture ID 1905563)

sugar major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of sugar substrates including glucose, galactose, mannose and fucose

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FucP super family cl43255
Fucose permease [Carbohydrate transport and metabolism];
75-239 5.26e-05

Fucose permease [Carbohydrate transport and metabolism];


The actual alignment was detected with superfamily member COG0738:

Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.62  E-value: 5.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   75 MLNLGFTIGSFVLSattLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRdvealSPLIFLALSLNGFG-GICLTFTS 153
Cdd:COG0738  47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGLGlGLLDVAAN 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971  154 LTLPNMFGNLRSTLMALMIGSYASSAITFPGI--KLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYT 231
Cdd:COG0738 119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLggLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG 198


                ....*...
gi 4505971  232 KKIKLSGL 239
Cdd:COG0738 199 SAASLKSL 206
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
75-239 5.26e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.62  E-value: 5.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   75 MLNLGFTIGSFVLSattLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRdvealSPLIFLALSLNGFG-GICLTFTS 153
Cdd:COG0738  47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGLGlGLLDVAAN 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971  154 LTLPNMFGNLRSTLMALMIGSYASSAITFPGI--KLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYT 231
Cdd:COG0738 119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLggLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG 198


                ....*...
gi 4505971  232 KKIKLSGL 239
Cdd:COG0738 199 SAASLKSL 206
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 68-219 8.77e-05

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 44.93  E-value: 8.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   68 GCDQQDEMLnlgFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALA-SRDVEALS-PLIFLALSLNGFG 145
Cdd:cd17354  34 GYSQQQNNL---LSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVvTGLISDLSfWLMCLCFFLIGNS 110

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4505971  146 GICLTFTSLTLPN-MFGNLRSTLMALMIGSYA-SSAITFPGIKLIYDAGVAFVVIMFTWsglacLIFLNCTLNWPI 219
Cdd:cd17354 111 TSSLYTAALVTCAkNFPESRGLAIGIPKGCYGlSGAIGSQLYKALFFHDSARVFLFLAV-----LPAVVGLLAWFS 181
MFS_1 pfam07690
Major Facilitator Superfamily;
75-211 3.60e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971     75 MLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRdvealSPLIFLALSLNGFGGICLTFTSL 154
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS-----LWLLLVLRVLQGLGAGALFPAAL 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4505971    155 TLPNMF--GNLRSTLMALMIGSYASSAITFPGIkliydAGVAFVVIMFTWSGLACLIFL 211
Cdd:pfam07690 108 ALIADWfpPEERGRALGLVSAGFGLGAALGPLL-----GGLLASLFGWRAAFLILAILS 161
 
Name Accession Description Interval E-value
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
75-239 5.26e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 45.62  E-value: 5.26e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   75 MLNLGFTIGSFVLSattLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRdvealSPLIFLALSLNGFG-GICLTFTS 153
Cdd:COG0738  47 LLLFAFFLGYLLAS---LPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPS-----YPLLLLALFLLGLGlGLLDVAAN 118

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971  154 LTLPNMFGNLRSTLMALMIGSYASSAITFPGI--KLIYDAGVAFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEEVNYT 231
Cdd:COG0738 119 PYVAALGPETAASRLNLLHAFFSLGALLGPLLggLLILLGLSLSWHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAG 198


                ....*...
gi 4505971  232 KKIKLSGL 239
Cdd:COG0738 199 SAASLKSL 206
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
78-211 8.22e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 45.26  E-value: 8.22e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   78 LGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASrdveALSPLIFLALsLNGFGGICLTFTSLTLP 157
Cdd:COG2223  44 LLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAV----SYWLLLLLGL-LLGIGGGGSFAVGIALV 118

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4505971  158 NMF--GNLRSTLMALMIGSY--ASSAITFPGIKLIYDAGVAFVviMFTWSGLACLIFL 211
Cdd:COG2223 119 SKWfpPDRRGLALGLAAGGGnlGAAVAAFLAPLLIAAFGWRNA--FLILGILLLVVAV 174
MFS_Mch1p_like cd17354
Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major ...
 68-219 8.77e-05

Monocarboxylate transporter-homologous (Mch) 1 protein and similar transporters of the Major Facilitator Superfamily of transporters; Yeast monocarboxylate transporter-homologous (Mch) proteins are putative transporters that do not transport monocarboxylic acids across the plasma membrane, and may play roles distinct from their mammalian counterparts. Their function has not been determined. The Mch1p-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340912 [Multi-domain]  Cd Length: 385  Bit Score: 44.93  E-value: 8.77e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   68 GCDQQDEMLnlgFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALA-SRDVEALS-PLIFLALSLNGFG 145
Cdd:cd17354  34 GYSQQQNNL---LSVAKDLGYLVGPLLGLLSDRLGPWLLLLIGAILFFPGYGVLWLVvTGLISDLSfWLMCLCFFLIGNS 110

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4505971  146 GICLTFTSLTLPN-MFGNLRSTLMALMIGSYA-SSAITFPGIKLIYDAGVAFVVIMFTWsglacLIFLNCTLNWPI 219
Cdd:cd17354 111 TSSLYTAALVTCAkNFPESRGLAIGIPKGCYGlSGAIGSQLYKALFFHDSARVFLFLAV-----LPAVVGLLAWFS 181
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
73-211 2.48e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 43.32  E-value: 2.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   73 DEMLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASrdvealSPLIFLAL-SLNGFG-GICLT 150
Cdd:COG2271  44 AAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFAT------SFWQLLLLrFLLGLGeAGFFP 117

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4505971  151 FTSLTLPNMF-GNLRSTLMALMIGSYASSAITFPGIkliydagVAFVVIMFTW------SGLACLIFL 211
Cdd:COG2271 118 AALKLIAEWFpPKERGRALGIFNAGGPLGGALAPPL-------LGWLLAAFGWraafliLGLPGLLLA 178
MFS_MT3072_like cd17475
Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar ...
 81-146 7.18e-04

Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072 and similar transporters of the Major Facilitator Superfamily; This family includes the Mycobacterium tuberculosis uncharacterized MFS-type transporter MT3072. It belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341028 [Multi-domain]  Cd Length: 378  Bit Score: 42.23  E-value: 7.18e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4505971   81 TIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRdvealSPLIFLALSLNGFGG 146
Cdd:cd17475  38 SALNLGVAVSMLPAGWLLDRFGERRVLAVGLLLMGAAALLMALVGS-----YPVLLVLLFLVGAGY 98
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 78-183 8.48e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 41.87  E-value: 8.48e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   78 LGFTIGsFVLSATTLPL-GILMDRFGPRPVRLVGSACFTASCTLMALASrdveALSPLIFLALSLNGFGGICLTF--TSL 154
Cdd:cd17355  42 LAFTVG-LLAFGLAQPFvGRLLDRFGPRRVMLLGLLLLAAGLVLLALAT----SLWQLYLLWGLLGGGGAGTLAAvaFAT 116

                        90       100
                ....*....|....*....|....*....
gi 4505971  155 TLPNMFGNLRSTLMALMIGSYASSAITFP 183
Cdd:cd17355 117 VAAWWFERRRGLALGILTAGGGLGSLVFL 145
MFS_OFA_like cd17353
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ...
 78-147 8.57e-04

Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340911 [Multi-domain]  Cd Length: 389  Bit Score: 41.83  E-value: 8.57e-04
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   78 LGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRdvealSPLIFLALSlnGFGGI 147
Cdd:cd17353  42 LAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAIS-----LPLLFLGYG--VLGGI 104
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 75-241 1.11e-03

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 41.64  E-value: 1.11e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   75 MLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALAsrdveALSPLIFLALSLNGFGGICLTFTSL 154
Cdd:cd06174  32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFA-----PSFWLLLLGRFLLGLGSGLIDPAVL 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971  155 TL------PNMFGNLRSTLMALMIGSYASSAITFPGIKLIYDAGV-AFVVIMFTWSGLACLIFLNCTLNWPIEAFPAPEE 227
Cdd:cd06174 107 ALiadlfpERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWrAVFLIAAALALLAAILLLLVVPDPPESARAKNEE 186

                       170
                ....*....|....
gi 4505971  228 VNYTKKIKLSGLAL 241
Cdd:cd06174 187 ASSKSVLKLLKRVL 200
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 76-203 1.41e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 41.15  E-value: 1.41e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   76 LNLGFTIGSFvlsattlPLGILMDRFGPRPVRLVGSACFTASCTLMALASrdveaLSPLIFLALSLNGFG-GICLTFTSL 154
Cdd:cd17333  40 QNAGYLIGSL-------LAGFLMKRLGRRRTLILGLLLISLALALIFATP-----SIYLFVVLMFLAGLGaGILDTGANT 107

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*....
gi 4505971  155 TLPNMFGNLRSTLMALMIGSYASSAITFPGIkliydaGVAFVVIMFTWS 203
Cdd:cd17333 108 FVGALFEESSATRLNVLHGFFGLGALIGPLI------ATSLLTSELSWS 150
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
78-175 2.81e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 2.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   78 LGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLP 157
Cdd:COG2814 247 LLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAP 326

                        90
                ....*....|....*...
gi 4505971  158 nmfGNLRSTLMALMIGSY 175
Cdd:COG2814 327 ---PEARGRASGLYNSAF 341
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
80-185 3.15e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 39.96  E-value: 3.15e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   80 FTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASrdvealSPLIFLALS-LNGFGGICLTFTSLTL-P 157
Cdd:COG2814  51 VTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP------SLWLLLAARfLQGLGAGALFPAALALiA 124

                        90       100
                ....*....|....*....|....*....
gi 4505971  158 NMF-GNLRSTLMALMIGSYASSAITFPGI 185
Cdd:COG2814 125 DLVpPERRGRALGLLGAGLGLGPALGPLL 153
MFS_1 pfam07690
Major Facilitator Superfamily;
75-211 3.60e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.71  E-value: 3.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971     75 MLNLGFTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRdvealSPLIFLALSLNGFGGICLTFTSL 154
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASS-----LWLLLVLRVLQGLGAGALFPAAL 107

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 4505971    155 TLPNMF--GNLRSTLMALMIGSYASSAITFPGIkliydAGVAFVVIMFTWSGLACLIFL 211
Cdd:pfam07690 108 ALIADWfpPEERGRALGLVSAGFGLGAALGPLL-----GGLLASLFGWRAAFLILAILS 161
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 78-145 4.76e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.46  E-value: 4.76e-03
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4505971   78 LGFTIGSFVLSATTlplGILMDRFGPRPVRLVGSACFTASCTLMALASRDveALSPLIFLALSLNGFG 145
Cdd:cd17321 211 LPLALAMLVAAPLA---GRLADRFGPRLVLVAGLLLTAVGLLLLALLGAD--SSVWLLLPGLVLLGLG 273
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 79-211 5.00e-03

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 39.50  E-value: 5.00e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   79 GFTIGSFVLSA--TTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASrdvealSPLIFLALSL-NGFG-GICLTFTSL 154
Cdd:cd17489  34 GLVVGLFTLAAllARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLAT------SVALLLVLRLiHGIGwGAFTTAAAT 107

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4505971  155 TLPNMFGN-LRSTLMALM-IGSYASSAItFPGIKLIYDAGVAFVVIMFTWSGLACLIFL 211
Cdd:cd17489 108 LVADIIPPsRRGEGIGYYgLATTLAMAL-GPALGLFLYQHLGFAVLFIVAAVLALLALL 165
MFS_1 pfam07690
Major Facilitator Superfamily;
80-183 5.29e-03

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 39.32  E-value: 5.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971     80 FTIGSFVLSATTLPLGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLALSLNGFGGICLTFTSLTLPNM 159
Cdd:pfam07690 241 LGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLA 320

                          90       100
                  ....*....|....*....|....
gi 4505971    160 FGNLRSTLMALMIGSYASSAITFP 183
Cdd:pfam07690 321 PKEERGTASGLYNTAGSLGGALGP 344
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 75-211 5.97e-03

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 39.11  E-value: 5.97e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505971   75 MLNLGFTIGSFVLsattlplGILMDRFGPRPVRLVGSACFTASCTLMALASRDVEALSPLIFLAlslngfgGICLTFTSL 154
Cdd:cd17365 214 LLNIGGVIGSLLL-------GWLADRFGPKRVLALFFALGAVSLALLGVSPASLVLLYVLVFLA-------GACVNGAQV 279

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4505971  155 TLPNMFGNL-----RSTLMALMIGSYASSAITFPGI-KLIYDAGVAFVVIMFTWSGLACLIFL 211
Cdd:cd17365 280 GLYALAARFyptevRATGVGWALGVGRLGAILGPLLgGLLLAAGLGPESVFLALAIPAALGAL 342
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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