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Conserved domains on  [gi|4502395|ref|NP_003757|]
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beclin-1 isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 267-445 5.63e-118

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


:

Pssm-ID: 461178  Cd Length: 176  Bit Score: 342.21  E-value: 5.63e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502395    267 TNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKS 346
Cdd:pfam04111   1 TNVYNDTFHISHDGPFGTINGLRLGRLPNVPVEWSEINAAWGQTALLLATLAKKLGLKFQGYKLVPMGSFSKIEKLDDDS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502395    347 KELPLYCSGGL---RFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDtggsggsYSIKTQFNS-E 422
Cdd:pfam04111  81 QELELYGSGDFslgLFFSERKFDKAMVAFLDCLQQLGEFLEKLDPEFELPYKIDKDKGKIGD-------YSIKLQFNTsD 153

                         170       180
                  ....*....|....*....|...
gi 4502395    423 EQWTKALKFMLTNLKWGLAWVSS 445
Cdd:pfam04111 154 EEWTKALKFMLTNLKWLLAWVSS 176
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 135-261 2.83e-35

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


:

Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 127.33  E-value: 2.83e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502395    135 PLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQMELKELALEEERLIQELEDVEKNRKIVAENLEK 214
Cdd:pfam17675   1 PLCEECTDLLLEELDKQLEDAEKERDAYISFLKKLEKETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAELEA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 4502395    215 VQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQL 261
Cdd:pfam17675  81 LEEELEALDEEEEEFWREYNALQLQLLEFQDERDSLEAQYEHALNQL 127
BH3 pfam15285
Beclin-1 BH3 domain, Bcl-2-interacting; The BH3 domain is a short motif known to bind to ...
 105-129 1.94e-11

Beclin-1 BH3 domain, Bcl-2-interacting; The BH3 domain is a short motif known to bind to Bcl-xLs. This interaction is important in apoptosis.


:

Pssm-ID: 464614  Cd Length: 25  Bit Score: 58.20  E-value: 1.94e-11
                          10        20
                  ....*....|....*....|....*
gi 4502395    105 DGGTMENLSRRLKVTGDLFDIMSGQ 129
Cdd:pfam15285   1 DGGTMDNLSHRLKVTGDLFDIMSGQ 25
 
Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 267-445 5.63e-118

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


Pssm-ID: 461178  Cd Length: 176  Bit Score: 342.21  E-value: 5.63e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502395    267 TNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKS 346
Cdd:pfam04111   1 TNVYNDTFHISHDGPFGTINGLRLGRLPNVPVEWSEINAAWGQTALLLATLAKKLGLKFQGYKLVPMGSFSKIEKLDDDS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502395    347 KELPLYCSGGL---RFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDtggsggsYSIKTQFNS-E 422
Cdd:pfam04111  81 QELELYGSGDFslgLFFSERKFDKAMVAFLDCLQQLGEFLEKLDPEFELPYKIDKDKGKIGD-------YSIKLQFNTsD 153

                         170       180
                  ....*....|....*....|...
gi 4502395    423 EQWTKALKFMLTNLKWGLAWVSS 445
Cdd:pfam04111 154 EEWTKALKFMLTNLKWLLAWVSS 176
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 135-261 2.83e-35

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 127.33  E-value: 2.83e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502395    135 PLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQMELKELALEEERLIQELEDVEKNRKIVAENLEK 214
Cdd:pfam17675   1 PLCEECTDLLLEELDKQLEDAEKERDAYISFLKKLEKETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAELEA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 4502395    215 VQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQL 261
Cdd:pfam17675  81 LEEELEALDEEEEEFWREYNALQLQLLEFQDERDSLEAQYEHALNQL 127
BH3 pfam15285
Beclin-1 BH3 domain, Bcl-2-interacting; The BH3 domain is a short motif known to bind to ...
 105-129 1.94e-11

Beclin-1 BH3 domain, Bcl-2-interacting; The BH3 domain is a short motif known to bind to Bcl-xLs. This interaction is important in apoptosis.


Pssm-ID: 464614  Cd Length: 25  Bit Score: 58.20  E-value: 1.94e-11
                          10        20
                  ....*....|....*....|....*
gi 4502395    105 DGGTMENLSRRLKVTGDLFDIMSGQ 129
Cdd:pfam15285   1 DGGTMDNLSHRLKVTGDLFDIMSGQ 25
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
145-268 6.87e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 47.97  E-value: 6.87e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502395  145 LDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQmelkELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQ 224
Cdd:COG4372  54 LEQAREELEQLEEELEQARSELEQLEEELEELNEQLQ----AAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQ 129

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 4502395  225 EEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTN 268
Cdd:COG4372 130 QRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQEL 173
 
Name Accession Description Interval E-value
APG6 pfam04111
Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 267-445 5.63e-118

Apg6 BARA domain; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway. This entry is the Beta-Alpha repeated, autophagy-specific (BARA) domain.


Pssm-ID: 461178  Cd Length: 176  Bit Score: 342.21  E-value: 5.63e-118
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502395    267 TNVFNATFHIWHSGQFGTINNFRLGRLPSVPVEWNEINAAWGQTVLLLHALANKMGLKFQRYRLVPYGNHSYLESLTDKS 346
Cdd:pfam04111   1 TNVYNDTFHISHDGPFGTINGLRLGRLPNVPVEWSEINAAWGQTALLLATLAKKLGLKFQGYKLVPMGSFSKIEKLDDDS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502395    347 KELPLYCSGGL---RFFWDNKFDHAMVAFLDCVQQFKEEVEKGETRFCLPYRMDVEKGKIEDtggsggsYSIKTQFNS-E 422
Cdd:pfam04111  81 QELELYGSGDFslgLFFSERKFDKAMVAFLDCLQQLGEFLEKLDPEFELPYKIDKDKGKIGD-------YSIKLQFNTsD 153

                         170       180
                  ....*....|....*....|...
gi 4502395    423 EQWTKALKFMLTNLKWGLAWVSS 445
Cdd:pfam04111 154 EEWTKALKFMLTNLKWLLAWVSS 176
APG6_N pfam17675
Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. ...
 135-261 2.83e-35

Apg6 coiled-coil region; In yeast, 15 Apg proteins coordinate the formation of autophagosomes. Autophagy is a bulk degradation process induced by starvation in eukaryotic cells. Apg6/Vps30p has two distinct functions in the autophagic process, either associated with the membrane or in a retrieval step of the carboxypeptidase Y sorting pathway.


Pssm-ID: 465452 [Multi-domain]  Cd Length: 127  Bit Score: 127.33  E-value: 2.83e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502395    135 PLCEECTDTLLDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQMELKELALEEERLIQELEDVEKNRKIVAENLEK 214
Cdd:pfam17675   1 PLCEECTDLLLEELDKQLEDAEKERDAYISFLKKLEKETPEELEELEKELEKLEKEEEELLQELEELEKEREELDAELEA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 4502395    215 VQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQL 261
Cdd:pfam17675  81 LEEELEALDEEEEEFWREYNALQLQLLEFQDERDSLEAQYEHALNQL 127
BH3 pfam15285
Beclin-1 BH3 domain, Bcl-2-interacting; The BH3 domain is a short motif known to bind to ...
 105-129 1.94e-11

Beclin-1 BH3 domain, Bcl-2-interacting; The BH3 domain is a short motif known to bind to Bcl-xLs. This interaction is important in apoptosis.


Pssm-ID: 464614  Cd Length: 25  Bit Score: 58.20  E-value: 1.94e-11
                          10        20
                  ....*....|....*....|....*
gi 4502395    105 DGGTMENLSRRLKVTGDLFDIMSGQ 129
Cdd:pfam15285   1 DGGTMDNLSHRLKVTGDLFDIMSGQ 25
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
145-268 6.87e-06

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 47.97  E-value: 6.87e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502395  145 LDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQmelkELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQ 224
Cdd:COG4372  54 LEQAREELEQLEEELEQARSELEQLEEELEELNEQLQ----AAQAELAQAQEELESLQEEAEELQEELEELQKERQDLEQ 129

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....
gi 4502395  225 EEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTN 268
Cdd:COG4372 130 QRKQLEAQIAELQSEIAEREEELKELEEQLESLQEELAALEQEL 173
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 145-266 6.62e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 42.23  E-value: 6.62e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4502395  145 LDQLDTQLNVTENECQNYKRCLEILEQMNEDDSEQLQmelkELALEEERLIQELEDVEKNRKIVAENLEKVQAEAERLDQ 224
Cdd:COG1196 297 LARLEQDIARLEERRRELEERLEELEEELAELEEELE----ELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEA 372

                        90       100       110       120
                ....*....|....*....|....*....|....*....|..
gi 4502395  225 EEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKK 266
Cdd:COG1196 373 ELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLE 414
MT pfam12777
Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA ...
 196-269 6.75e-04

Microtubule-binding stalk of dynein motor; the 380 kDa motor unit of dynein belongs to the AAA class of chaperone-like ATPases. The core of the 380 kDa motor unit contains a concatenated chain of six AAA modules, of which four correspond to the ATP binding sites with P-loop signatures described previously, and two are modules in which the P loop has been lost in evolution. This family is the region between D4 and D5 and is the two predicted alpha-helical coiled coil segments that form the stalk supporting the ATP-sensitive microtubule binding component.


Pssm-ID: 463699 [Multi-domain]  Cd Length: 344  Bit Score: 41.60  E-value: 6.75e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4502395    196 QELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTNV 269
Cdd:pfam12777  33 QKNEDADKLIQVVGIEADKVSKEKAIADEEEQKVAVIMKEVKEKQKACEEDLAKAEPALLAAQAALDTLNKNNL 106
COG4372 COG4372
Uncharacterized protein, contains DUF3084 domain [Function unknown];
196-266 1.69e-03

Uncharacterized protein, contains DUF3084 domain [Function unknown];


Pssm-ID: 443500 [Multi-domain]  Cd Length: 370  Bit Score: 40.66  E-value: 1.69e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502395  196 QELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKK 266
Cdd:COG4372  52 EELEQAREELEQLEEELEQARSELEQLEEELEELNEQLQAAQAELAQAQEELESLQEEAEELQEELEELQK 122
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 196-266 3.47e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 39.36  E-value: 3.47e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4502395  196 QELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKK 266
Cdd:COG4942  34 QEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKE 104
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 196-272 4.30e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 38.75  E-value: 4.30e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4502395  196 QELEDVEKNRKIVAENLEKVQAEAERLDQEEAQYQREYSEFKRQQLELDDELKSVENQMRYAQTQLDKLKKTNVFNA 272
Cdd:COG1579  17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQLGNVRNNKEYEA 93
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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