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Conserved domains on  [gi|24041020|ref|NP_003788|]
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polycomb protein EED isoform a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
109-439 3.20e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 3.20e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 109 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 187
Cdd:COG2319  89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 188 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 268 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKP 345
Cdd:COG2319 236 GKLL----------------------------RTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLW-------DLATGEL 280

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 346 sesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHkcGAAIRQTSFSRDSSIL 425
Cdd:COG2319 281 -------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR----TLTGH--TGAVRSVAFSPDGKTL 345

                       330
                ....*....|....
gi 24041020 426 IAVCDDASIWRWDR 439
Cdd:COG2319 346 ASGSDDGTVRLWDL 359
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
109-439 3.20e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 3.20e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 109 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 187
Cdd:COG2319  89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 188 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 268 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKP 345
Cdd:COG2319 236 GKLL----------------------------RTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLW-------DLATGEL 280

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 346 sesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHkcGAAIRQTSFSRDSSIL 425
Cdd:COG2319 281 -------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR----TLTGH--TGAVRSVAFSPDGKTL 345

                       330
                ....*....|....
gi 24041020 426 IAVCDDASIWRWDR 439
Cdd:COG2319 346 ASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-438 1.11e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 1.11e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 150 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 229
Cdd:cd00200  15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 230 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK------ESYDYNPNKTnrpFIS-----QKIHFPD 298
Cdd:cd00200  90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtdwvNSVAFSPDGT---FVAsssqdGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 299 FS------TRDIHRNYVDCVRWLGD--LILSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSm 370
Cdd:cd00200 164 LRtgkcvaTLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLW-------DLSTGKC-------LGTLRGHENGVNSVAFS- 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24041020 371 dFWQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 438
Cdd:cd00200 229 -PDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHT--NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-219 6.37e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.37e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 24041020    179 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-219 3.15e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 24041020   180 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 167-269 1.54e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020  167 GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGG----VEGHRDEVLS 241
Cdd:PTZ00420  51 GLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqciLKGHKKKISI 130

                         90       100       110
                 ....*....|....*....|....*....|
gi 24041020  242 ADYDLLGEKIM-SCGMDHSLKLWRI-NSKR 269
Cdd:PTZ00420 131 IDWNPMNYYIMcSSGFDSFVNIWDIeNEKR 160
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
109-439 3.20e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.84  E-value: 3.20e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 109 DPLVFATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshplLAVAGSRGIIRIINPITMQCIKHYV 187
Cdd:COG2319  89 DGRLLASASAdGTVRLWDLATGLLLRTLTGHTGA-----VRSVAFSPDGKT----LASGSADGTVRLWDLATGKLLRTLT 159

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 188 GHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINS 267
Cdd:COG2319 160 GHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTL---TGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLAT 235

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 268 KRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLILSKSCENAIVCWkpgkmedDIDKIKP 345
Cdd:COG2319 236 GKLL----------------------------RTLTGHSGSVRSVAFSpdGRLLASGSADGTVRLW-------DLATGEL 280

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 346 sesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHkcGAAIRQTSFSRDSSIL 425
Cdd:COG2319 281 -------LRTLTGHSGGVNSVAFSPD--GKLLASGSDDGTVRLWDLATGKLLR----TLTGH--TGAVRSVAFSPDGKTL 345

                       330
                ....*....|....
gi 24041020 426 IAVCDDASIWRWDR 439
Cdd:COG2319 346 ASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
162-438 2.27e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 101.14  E-value: 2.27e-23
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 241
Cdd:COG2319 176 LLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTL---TGHSGSVRS 251

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMnaikesydynpnktnrpfisqkihfpdfSTRDIHRNYVDCVRWL--GDLI 319
Cdd:COG2319 252 VAFSPDGRLLASGSADGTVRLWDLATGELL----------------------------RTLTGHSGGVNSVAFSpdGKLL 303

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 320 LSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLEVedphKA 399
Cdd:COG2319 304 ASGSDDGTVRLW-------DLATGKL-------LRTLTGHTGAVRSVAFSPD--GKTLASGSDDGTVRLWDLAT----GE 363

                       250       260       270
                ....*....|....*....|....*....|....*....
gi 24041020 400 KCTTLTHHkcGAAIRQTSFSRDSSILIAVCDDASIWRWD 438
Cdd:COG2319 364 LLRTLTGH--TGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 150-438 1.11e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 97.41  E-value: 1.11e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 150 CAWTYDSNtshpLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDpNLLLSVSKDHALRLWNIQTDTLVAIF 229
Cdd:cd00200  15 VAFSPDGK----LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTL 89

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 230 ggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIK------ESYDYNPNKTnrpFIS-----QKIHFPD 298
Cdd:cd00200  90 ---TGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRghtdwvNSVAFSPDGT---FVAsssqdGTIKLWD 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 299 FS------TRDIHRNYVDCVRWLGD--LILSKSCENAIVCWkpgkmedDIDKIKPsesnvtiLGRFDYSQCDIWYMRFSm 370
Cdd:cd00200 164 LRtgkcvaTLTGHTGEVNSVAFSPDgeKLLSSSSDGTIKLW-------DLSTGKC-------LGTLRGHENGVNSVAFS- 228

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 24041020 371 dFWQKMLALGNQVGKLYVWDLEVEDPHKakctTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 438
Cdd:cd00200 229 -PDGYLLASGSEDGTIRVWDLRTGECVQ----TLSGHT--NSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
83-392 5.91e-18

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 85.35  E-value: 5.91e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020  83 KCVNSLKEdHNQPLFGVQFnwhSKEGDPLvfATVGS-NRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshp 161
Cdd:COG2319 153 KLLRTLTG-HSGAVTSVAF---SPDGKLL--ASGSDdGTVRLWDLATGKLLRTLTGHTGA-----VRSVAFSPDGKL--- 218

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 162 lLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFGgveGHRDEVLS 241
Cdd:COG2319 219 -LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTVRLWDLATGELLRTLT---GHSGGVNS 293

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKEsydynpnktnrpfisqkihfpdfstrdiHRNYVDCVRW--LGDLI 319
Cdd:COG2319 294 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG----------------------------HTGAVRSVAFspDGKTL 345

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 24041020 320 LSKSCENAIVCWkpgkmedDIDkikpsesNVTILGRFDYSQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDLE 392
Cdd:COG2319 346 ASGSDDGTVRLW-------DLA-------TGELLRTLTGHTGAVTSVAFSPD--GRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 81-264 1.67e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.69  E-value: 1.67e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020  81 SFKCVNSLKeDHNQPLFGVQFNWHSKegdplvFATVGS--NRVTLYECHSQGEIRLLQSYvdadaDENFYTCAWTYDSNT 158
Cdd:cd00200 124 TGKCLTTLR-GHTDWVNSVAFSPDGT------FVASSSqdGTIKLWDLRTGKCVATLTGH-----TGEVNSVAFSPDGEK 191

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 159 shplLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDE 238
Cdd:cd00200 192 ----LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSP-DGYLLASGSEDGTIRVWDLRTGECVQTL---SGHTNS 263

                       170       180
                ....*....|....*....|....*.
gi 24041020 239 VLSADYDLLGEKIMSCGMDHSLKLWR 264
Cdd:cd00200 264 VTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
83-267 2.57e-16

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 80.34  E-value: 2.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020  83 KCVNSLKeDHNQPLFGVQFnwhSKEGDPLVFATvGSNRVTLYECHSQGEIRLLQSYVDAdadenFYTCAWTYDSNTshpl 162
Cdd:COG2319 237 KLLRTLT-GHSGSVRSVAF---SPDGRLLASGS-ADGTVRLWDLATGELLRTLTGHSGG-----VNSVAFSPDGKL---- 302

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 163 LAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLSA 242
Cdd:COG2319 303 LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKTLASGSDDGTVRLWDLATGELLRTL---TGHTGAVTSV 378

                       170       180
                ....*....|....*....|....*
gi 24041020 243 DYDLLGEKIMSCGMDHSLKLWRINS 267
Cdd:COG2319 379 AFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 148-331 4.84e-15

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 75.06  E-value: 4.84e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 148 YTCAWtydsNTSHPLLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVA 227
Cdd:cd00200  97 SSVAF----SPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQDGTIKLWDLRTGKCVA 171

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 228 IFggvEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINSKRMMNaikesydynpnktnrpfisqkihfpdfsTRDIHRN 307
Cdd:cd00200 172 TL---TGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLG----------------------------TLRGHEN 220

                       170       180
                ....*....|....*....|....*.
gi 24041020 308 YVDCVRWL--GDLILSKSCENAIVCW 331
Cdd:cd00200 221 GVNSVAFSpdGYLLASGSEDGTIRVW 246
WD40 COG2319
WD40 repeat [General function prediction only];
162-438 3.25e-10

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 61.47  E-value: 3.25e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 162 LLAVAGSRGIIRIINPITMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWNIQTDTLVAIFggvEGHRDEVLS 241
Cdd:COG2319  50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSP-DGRLLASASADGTVRLWDLATGLLLRTL---TGHTGAVRS 125

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 242 ADYDLLGEKIMSCGMDHSLKLWRINSKRMMNAIKEsydynpnktnrpfisqkihfpdfstrdiHRNYVDCVRWLGDlils 321
Cdd:COG2319 126 VAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG----------------------------HSGAVTSVAFSPD---- 173

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 322 kscenaivcwkpgkmeddidkikpsesnvtilGRFdysqcdiwymrfsmdfwqkmLALGNQVGKLYVWDLEvedphKAKC 401
Cdd:COG2319 174 --------------------------------GKL--------------------LASGSDDGTVRLWDLA-----TGKL 196

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 24041020 402 -TTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 438
Cdd:COG2319 197 lRTLTGHT--GAVRSVAFSPDGKLLASGSADGTVRLWD 232
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 232-438 3.58e-06

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 48.49  E-value: 3.58e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 232 VEGHRDEVLSADYDLLGEKIMSCGMDHSLKLWRINskrmmnaikesydynpnkTNRPFISQKIHFPDFSTrdihrnyVDC 311
Cdd:cd00200   5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLE------------------TGELLRTLKGHTGPVRD-------VAA 59

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020 312 VRWlGDLILSKSCENAIVCWKPGKmeddidkikpSESNVTILGrfdySQCDIWYMRFSMDfwQKMLALGNQVGKLYVWDL 391
Cdd:cd00200  60 SAD-GTYLASGSSDKTIRLWDLET----------GECVRTLTG----HTSYVSSVAFSPD--GRILSSSSRDKTIKVWDV 122

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 24041020 392 EVEDPhkakCTTLTHHKcgAAIRQTSFSRDSSILIAVCDDASIWRWD 438
Cdd:cd00200 123 ETGKC----LTTLRGHT--DWVNSVAFSPDGTFVASSSQDGTIKLWD 163
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-219 6.37e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.99  E-value: 6.37e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 24041020    179 TMQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
180-219 3.15e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 3.15e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 24041020   180 MQCIKHYVGHGNAINELKFHPrDPNLLLSVSKDHALRLWN 219
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
PTZ00420 PTZ00420
coronin; Provisional
 167-269 1.54e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 40.70  E-value: 1.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020  167 GSRGIIRIINPITMQCIKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNI-QTDTLVAIFGG----VEGHRDEVLS 241
Cdd:PTZ00420  51 GLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIpHNDESVKEIKDpqciLKGHKKKISI 130

                         90       100       110
                 ....*....|....*....|....*....|
gi 24041020  242 ADYDLLGEKIM-SCGMDHSLKLWRI-NSKR 269
Cdd:PTZ00420 131 IDWNPMNYYIMcSSGFDSFVNIWDIeNEKR 160
PTZ00421 PTZ00421
coronin; Provisional
 183-409 5.41e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 39.11  E-value: 5.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020  183 IKHYVGHGNAINELKFHPRDPNLLLSVSKDHALRLWNIQTDTLVAIfggVEGHRDEVLSADYDLLGEKIMSCGMDHSLkl 262
Cdd:PTZ00421 118 IVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEV---IKCHSDQITSLEWNLDGSLLCTTSKDKKL-- 192

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 24041020  263 wRINSKRMMNAIKESYDYNPNKTNRPFISQKihfpdfstrdihrnyVDCVRWLGdliLSKSCENAIVCWKPGKMEDDIDK 342
Cdd:PTZ00421 193 -NIIDPRDGTIVSSVEAHASAKSQRCLWAKR---------------KDLIITLG---CSKSQQRQIMLWDTRKMASPYST 253

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 24041020  343 IKPSESNVTILGRFDySQCDIWYMRFSMDFWQKMLALGNQvGKLYVWDLEVEDPHKAKCT----TLTHHKC 409
Cdd:PTZ00421 254 VDLDQSSALFIPFFD-EDTNLLYIGSKGEGNIRCFELMNE-RLTFCSSYSSVEPHKGLCMmpkwSLDTRKC 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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