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Conserved domains on  [gi|4507925|ref|NP_003871|]
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cellular communication network factor 6 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 209-252 1.23e-13

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 64.28  E-value: 1.23e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4507925    209 CLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPC 252
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
48-100 3.18e-10

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 55.02  E-value: 3.18e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4507925     48 CHWPC---KCPQQKPRCPPGVslVRDGCGCCKICAKQPGEICNEADL-CDphKGLYC 100
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTPpCG--KGLRC 53
GHB_like super family cl21545
Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the ...
 275-341 2.50e-04

Glycoprotein hormone beta chain homologues; This family of cystine-knot hormones includes the beta chains of gonadotropins, thyrotropins, follitropins, choriogonadotropins and more. The members are reproductive hormones that consist of two glycosylated chains (alpha and beta), which form a tightly bound dimer.


The actual alignment was detected with superfamily member smart00041:

Pssm-ID: 473907  Cd Length: 82  Bit Score: 39.31  E-value: 2.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507925     275 SKAEKFVFSGCSSTQsYKPTFC-GICLDK------------RCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNC 341
Cdd:smart00041   3 PVRQTITYNGCTSVT-VKNAFCeGKCGSAssysiqdvqhscSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPNC 81
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 209-252 1.23e-13

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 64.28  E-value: 1.23e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4507925    209 CLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPC 252
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
48-100 3.18e-10

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 55.02  E-value: 3.18e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4507925     48 CHWPC---KCPQQKPRCPPGVslVRDGCGCCKICAKQPGEICNEADL-CDphKGLYC 100
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTPpCG--KGLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 51-108 2.80e-06

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 44.76  E-value: 2.80e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 4507925      51 PCKCPQQKPRCPPGVslVRDGCGCCKICAKQPGEICNeADLCDPHKGLYCDYSVDRPR 108
Cdd:smart00121   8 PARCPPCPPGCAELV--RLDGCGCCPVCARQEGEPCG-VYTPRCAPGLRCQPPPGEER 62
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 275-341 2.50e-04

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 39.31  E-value: 2.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507925     275 SKAEKFVFSGCSSTQsYKPTFC-GICLDK------------RCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNC 341
Cdd:smart00041   3 PVRQTITYNGCTSVT-VKNAFCeGKCGSAssysiqdvqhscSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPNC 81
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 209-252 1.23e-13

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 64.28  E-value: 1.23e-13
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4507925    209 CLVQATKWTPCSRTCGMGISNRVTNENSNCEMRKEKRLCYIQPC 252
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
48-100 3.18e-10

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 55.02  E-value: 3.18e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4507925     48 CHWPC---KCPQQKPRCPPGVslVRDGCGCCKICAKQPGEICNEADL-CDphKGLYC 100
Cdd:pfam00219   1 CPPPCdpeRCPPPPPGCPAGV--VLDGCGCCKVCARQEGEPCGVYTPpCG--KGLRC 53
IB smart00121
Insulin growth factor-binding protein homologues; High affinity binding partners of ...
 51-108 2.80e-06

Insulin growth factor-binding protein homologues; High affinity binding partners of insulin-like growth factors.


Pssm-ID: 197525  Cd Length: 75  Bit Score: 44.76  E-value: 2.80e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 4507925      51 PCKCPQQKPRCPPGVslVRDGCGCCKICAKQPGEICNeADLCDPHKGLYCDYSVDRPR 108
Cdd:smart00121   8 PARCPPCPPGCAELV--RLDGCGCCPVCARQEGEPCG-VYTPRCAPGLRCQPPPGEER 62
CT smart00041
C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta ...
 275-341 2.50e-04

C-terminal cystine knot-like domain (CTCK); The structures of transforming growth factor-beta (TGFbeta), nerve growth factor (NGF), platelet-derived growth factor (PDGF) and gonadotropin all form 2 highly twisted antiparallel pairs of beta-strands and contain three disulphide bonds. The domain is non-globular and little is conserved among these presumed homologues except for their cysteine residues. CT domains are predicted to form homodimers.


Pssm-ID: 214482  Cd Length: 82  Bit Score: 39.31  E-value: 2.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4507925     275 SKAEKFVFSGCSSTQsYKPTFC-GICLDK------------RCCIPNKSKMITIQFDCPNEGSFKWKMLWITSCVCQRNC 341
Cdd:smart00041   3 PVRQTITYNGCTSVT-VKNAFCeGKCGSAssysiqdvqhscSCCQPHKTKTRQVRLRCPDGSTVKKTVMHIEECGCEPNC 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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