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Conserved domains on  [gi|4507923|ref|NP_003872|]
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CCN family member 5 isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 194-237 5.31e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


:

Pssm-ID: 465952  Cd Length: 44  Bit Score: 69.67  E-value: 5.31e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4507923    194 CPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPC 237
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
45-78 4.48e-04

Insulin-like growth factor binding protein;


:

Pssm-ID: 459717  Cd Length: 53  Bit Score: 37.30  E-value: 4.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 4507923     45 LVLDGCGCCRVCARRLGEPCDQLH-VCDasQGLVC 78
Cdd:pfam00219  21 VVLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
VWC super family cl17735
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-160 6.16e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


The actual alignment was detected with superfamily member pfam00093:

Pssm-ID: 450195  Cd Length: 57  Bit Score: 37.02  E-value: 6.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507923    100 CEVNGRLYREGETFQPHCSIRCRCEDGGFTCvplcsEDVRLPSWDCPHPRRVEVLGKCCPE 160
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLC-----DKIICPPLDCPNPRLEIPPGECCPV 56
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 194-237 5.31e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 69.67  E-value: 5.31e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4507923    194 CPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPC 237
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
45-78 4.48e-04

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 37.30  E-value: 4.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 4507923     45 LVLDGCGCCRVCARRLGEPCDQLH-VCDasQGLVC 78
Cdd:pfam00219  21 VVLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-160 6.16e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 6.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507923    100 CEVNGRLYREGETFQPHCSIRCRCEDGGFTCvplcsEDVRLPSWDCPHPRRVEVLGKCCPE 160
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLC-----DKIICPPLDCPNPRLEIPPGECCPV 56
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 6.54e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.11  E-value: 6.54e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507923     100 CEVNGRLYREGETFQPHCSIRCRCEDGGF-TCVPLCSEdvrlPSWDCPHPRRVEVLGKCCP 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECP----PPPDCPNPERVKPPGECCP 57
 
Name Accession Description Interval E-value
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 194-237 5.31e-16

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 69.67  E-value: 5.31e-16
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 4507923    194 CPEWSTAWGPCSTTCGLGMATRVSNQNRFCRLETQRRLCLSRPC 237
Cdd:pfam19035   1 CEEQSTEWSPCSKTCGMGVSTRVSNDNAECKLVTETRLCQLRPC 44
IGFBP pfam00219
Insulin-like growth factor binding protein;
45-78 4.48e-04

Insulin-like growth factor binding protein;


Pssm-ID: 459717  Cd Length: 53  Bit Score: 37.30  E-value: 4.48e-04
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 4507923     45 LVLDGCGCCRVCARRLGEPCDQLH-VCDasQGLVC 78
Cdd:pfam00219  21 VVLDGCGCCKVCARQEGEPCGVYTpPCG--KGLRC 53
VWC pfam00093
von Willebrand factor type C domain; The high cutoff was used to prevent overlap with ...
 100-160 6.16e-04

von Willebrand factor type C domain; The high cutoff was used to prevent overlap with pfam00094.


Pssm-ID: 278520  Cd Length: 57  Bit Score: 37.02  E-value: 6.16e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507923    100 CEVNGRLYREGETFQPHCSIRCRCEDGGFTCvplcsEDVRLPSWDCPHPRRVEVLGKCCPE 160
Cdd:pfam00093   1 CVQNGVVYENGETWKPDLCTICTCDDGKVLC-----DKIICPPLDCPNPRLEIPPGECCPV 56
VWC smart00214
von Willebrand factor (vWF) type C domain;
100-159 6.54e-04

von Willebrand factor (vWF) type C domain;


Pssm-ID: 214564  Cd Length: 59  Bit Score: 37.11  E-value: 6.54e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4507923     100 CEVNGRLYREGETFQPHCSIRCRCEDGGF-TCVPLCSEdvrlPSWDCPHPRRVEVLGKCCP 159
Cdd:smart00214   1 CVHNGRVYNDGETWKPDPCQICTCLDGTTvLCDPVECP----PPPDCPNPERVKPPGECCP 57
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 196-237 7.47e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 33.79  E-value: 7.47e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 4507923    196 EWStAWGPCSTTCGLGMATRV-------SNQNRFCRLETQRRLCLSRPC 237
Cdd:pfam19028   5 EWS-EWSECSVTCGGGVQTRTrtvivepQNGGRPCPELLERRPCNLPPC 52
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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