Death Domain Superfamily of protein-protein interaction domains; The Death Domain (DD) superfamily includes the DD, Pyrin, CARD (Caspase activation and recruitment domain) and DED (Death Effector Domain) families. DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily. They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes. They are prominent components of the programmed cell death (apoptosis) pathway and are found in a number of other signaling pathways including those that impact innate immunity, inflammation, differentiation, and cancer.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505419       5 QERPSETIDRERKRLVETLQADsgLLLDALLARGVLTGPEYEALDALPDAERRVRRLLLLVQGKGEAACQELLRCAQRT- 83
Cdd:smart00114   2 AERDKRLLRRNRVRLGEELGVD--GLLDYLVEKNVLTEKEIEAIKAATTKLRDKRELVDSLQKRGSQAFDTFLDSLQETd 79

                   ....*....
gi 4505419      84 AGAPDPAWD 92
Cdd:smart00114  80 QKLADFLEL 88

Caspase recruitment domain; Motif contained in proteins involved in apoptotic signalling. Mediates homodimerisation. Structure consists of six antiparallel helices arranged in a topology homologue to the DEATH and the DED domain.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505419       5 QERPSETIDRERKRLVETLQADsgLLLDALLARGVLTGPEYEALDALPDAERRVRRLLLLVQGKGEAACQELLRCAQRT- 83
Cdd:smart00114   2 AERDKRLLRRNRVRLGEELGVD--GLLDYLVEKNVLTEKEIEAIKAATTKLRDKRELVDSLQKRGSQAFDTFLDSLQETd 79

                   ....*....
gi 4505419      84 AGAPDPAWD 92
Cdd:smart00114  80 QKLADFLEL 88

Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase activation and recruitment domains (CARDs) are death domains (DDs) found associated with caspases. Caspases are aspartate-specific cysteine proteases with functions in apoptosis, immune signaling, inflammation, and host-defense mechanisms. In addition to caspases, proteins containing CARDs include adaptor proteins such as RAIDD, CARD9, and RIG-I-like helicases, which can form multiprotein complexes and play important roles in mediating the signals to induce immune and inflammatory responses. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505419   12 IDRERKRLVETLQADSglLLDALLARGVLTGPEYEA--------------LDALPdaerrvrrllllvqGKGEAACQELL 77
Cdd:cd01671   1 LRKNRVELVEDLDVED--ILDHLIQKGVLTEEDKEEilsektrqdkarklLDILP--------------RRGPKAFEVFC 64

                ....*.
gi 4505419   78 RCAQRT 83
Cdd:cd01671  65 EALRET 70

Caspase recruitment domain; Motif contained in proteins involved in apoptotic signalling. Mediates homodimerisation. Structure consists of six antiparallel helices arranged in a topology homologue to the DEATH and the DED domain.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505419       5 QERPSETIDRERKRLVETLQADsgLLLDALLARGVLTGPEYEALDALPDAERRVRRLLLLVQGKGEAACQELLRCAQRT- 83
Cdd:smart00114   2 AERDKRLLRRNRVRLGEELGVD--GLLDYLVEKNVLTEKEIEAIKAATTKLRDKRELVDSLQKRGSQAFDTFLDSLQETd 79

                   ....*....
gi 4505419      84 AGAPDPAWD 92
Cdd:smart00114  80 QKLADFLEL 88

Caspase activation and recruitment domain: a protein-protein interaction domain; Caspase activation and recruitment domains (CARDs) are death domains (DDs) found associated with caspases. Caspases are aspartate-specific cysteine proteases with functions in apoptosis, immune signaling, inflammation, and host-defense mechanisms. In addition to caspases, proteins containing CARDs include adaptor proteins such as RAIDD, CARD9, and RIG-I-like helicases, which can form multiprotein complexes and play important roles in mediating the signals to induce immune and inflammatory responses. In general, DDs are protein-protein interaction domains found in a variety of domain architectures. Their common feature is that they form homodimers by self-association or heterodimers by associating with other members of the DD superfamily including PYRIN and DED (Death Effector Domain). They serve as adaptors in signaling pathways and can recruit other proteins into signaling complexes.

                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4505419   12 IDRERKRLVETLQADSglLLDALLARGVLTGPEYEA--------------LDALPdaerrvrrllllvqGKGEAACQELL 77
Cdd:cd01671   1 LRKNRVELVEDLDVED--ILDHLIQKGVLTEEDKEEilsektrqdkarklLDILP--------------RRGPKAFEVFC 64

                ....*.
gi 4505419   78 RCAQRT 83
Cdd:cd01671  65 EALRET 70