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Conserved domains on  [gi|78000181|ref|NP_003964|]
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large ribosomal subunit protein eL14 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
eL14 cd23702
Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the ...
 5-123 3.57e-38

Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the large subunit (LSU) of the microsporidian ribosome that reveals a prokaryotic-like rRNA core covered with eukaryotic ribosomal proteins.


:

Pssm-ID: 467915 [Multi-domain]  Cd Length: 82  Bit Score: 127.18  E-value: 3.57e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181   5 RFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMPFKCMQLTDFILKFPhsahqkyvrqawqkadint 84
Cdd:cd23702   1 RFVEVGRVVLINYGPDAGKLAVIVDIIDQNRVLVDGPKTGVKRQVVNLKRLSLTDFVVKIP------------------- 61

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 78000181  85 kwaatrwakkiearerkaKMTDFDRFKVMKAKKMRNRII 123
Cdd:cd23702  62 ------------------NLTDFDRFKVMLAKKKRRKLV 82
valS super family cl36437
valyl-tRNA synthetase; Provisional
 123-210 6.09e-09

valyl-tRNA synthetase; Provisional


The actual alignment was detected with superfamily member PRK14900:

Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 55.38  E-value: 6.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181   123 IKNEVKKLQKAALLKASPKKAPGTKGTAAAAAAAaaaKVPAKKitAASKKAPAQKVPAQKATGQKAAPAPKAQKGQKAPA 202
Cdd:PRK14900  970 VAEAVRKTVRRSVKKAAATRAAMKKKVAKKAPAK---KAAAKK--AAAKKAAAKKKVAKKAPAKKVARKPAAKKAAKKPA 1044


                  ....*...
gi 78000181   203 QKAPAPKA 210
Cdd:PRK14900 1045 RKAAGRKA 1052
 
Name Accession Description Interval E-value
eL14 cd23702
Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the ...
 5-123 3.57e-38

Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the large subunit (LSU) of the microsporidian ribosome that reveals a prokaryotic-like rRNA core covered with eukaryotic ribosomal proteins.


Pssm-ID: 467915 [Multi-domain]  Cd Length: 82  Bit Score: 127.18  E-value: 3.57e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181   5 RFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMPFKCMQLTDFILKFPhsahqkyvrqawqkadint 84
Cdd:cd23702   1 RFVEVGRVVLINYGPDAGKLAVIVDIIDQNRVLVDGPKTGVKRQVVNLKRLSLTDFVVKIP------------------- 61

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 78000181  85 kwaatrwakkiearerkaKMTDFDRFKVMKAKKMRNRII 123
Cdd:cd23702  62 ------------------NLTDFDRFKVMLAKKKRRKLV 82
PTZ00065 PTZ00065
60S ribosomal protein L14; Provisional
 2-128 3.72e-31

60S ribosomal protein L14; Provisional


Pssm-ID: 240252 [Multi-domain]  Cd Length: 130  Bit Score: 110.62  E-value: 3.72e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181    2 VFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGP-CTQVRRQAMPFKCMQLTDFILKFPHSAHQKYVRQAWQKA 80
Cdd:PTZ00065   3 LFKRFVEPGRLCLIQYGPDAGKLCFIVDIVTPTRVLVDGAfITGVKRQSIPLKRLKLTDEKIKINRGARTGTLKKALKKD 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 78000181   81 DINTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMRNRIIKNEVK 128
Cdd:PTZ00065  83 NALEEFNKTSLGKKLIIKEKRANMTDFERFKLMVAKKERRKLMKSLKK 130
Ribosomal_L14e pfam01929
Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.
 47-120 9.58e-31

Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.


Pssm-ID: 460388  Cd Length: 74  Bit Score: 107.97  E-value: 9.58e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 78000181    47 RQAMPFKCMQLTDFILKFPHSAHQKYVRQAWQKADINTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMRN 120
Cdd:pfam01929   1 RQVIPLKRLHLTKFVIKLPRGARTGAVKKAWEKADVDEKWAESAWAKKLAAREKRANLTDFDRFKVMVAKKQRR 74
valS PRK14900
valyl-tRNA synthetase; Provisional
 123-210 6.09e-09

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 55.38  E-value: 6.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181   123 IKNEVKKLQKAALLKASPKKAPGTKGTAAAAAAAaaaKVPAKKitAASKKAPAQKVPAQKATGQKAAPAPKAQKGQKAPA 202
Cdd:PRK14900  970 VAEAVRKTVRRSVKKAAATRAAMKKKVAKKAPAK---KAAAKK--AAAKKAAAKKKVAKKAPAKKVARKPAAKKAAKKPA 1044


                  ....*...
gi 78000181   203 QKAPAPKA 210
Cdd:PRK14900 1045 RKAAGRKA 1052
 
Name Accession Description Interval E-value
eL14 cd23702
Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the ...
 5-123 3.57e-38

Vairimorpha necatrix ribosomal protein eL14 and similar proteins; eL14 is a component of the large subunit (LSU) of the microsporidian ribosome that reveals a prokaryotic-like rRNA core covered with eukaryotic ribosomal proteins.


Pssm-ID: 467915 [Multi-domain]  Cd Length: 82  Bit Score: 127.18  E-value: 3.57e-38
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181   5 RFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPCTQVRRQAMPFKCMQLTDFILKFPhsahqkyvrqawqkadint 84
Cdd:cd23702   1 RFVEVGRVVLINYGPDAGKLAVIVDIIDQNRVLVDGPKTGVKRQVVNLKRLSLTDFVVKIP------------------- 61

                        90       100       110
                ....*....|....*....|....*....|....*....
gi 78000181  85 kwaatrwakkiearerkaKMTDFDRFKVMKAKKMRNRII 123
Cdd:cd23702  62 ------------------NLTDFDRFKVMLAKKKRRKLV 82
PTZ00065 PTZ00065
60S ribosomal protein L14; Provisional
 2-128 3.72e-31

60S ribosomal protein L14; Provisional


Pssm-ID: 240252 [Multi-domain]  Cd Length: 130  Bit Score: 110.62  E-value: 3.72e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181    2 VFRRFVEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGP-CTQVRRQAMPFKCMQLTDFILKFPHSAHQKYVRQAWQKA 80
Cdd:PTZ00065   3 LFKRFVEPGRLCLIQYGPDAGKLCFIVDIVTPTRVLVDGAfITGVKRQSIPLKRLKLTDEKIKINRGARTGTLKKALKKD 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 78000181   81 DINTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMRNRIIKNEVK 128
Cdd:PTZ00065  83 NALEEFNKTSLGKKLIIKEKRANMTDFERFKLMVAKKERRKLMKSLKK 130
Ribosomal_L14e pfam01929
Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.
 47-120 9.58e-31

Ribosomal protein L14; This family includes the eukaryotic ribosomal protein L14.


Pssm-ID: 460388  Cd Length: 74  Bit Score: 107.97  E-value: 9.58e-31
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 78000181    47 RQAMPFKCMQLTDFILKFPHSAHQKYVRQAWQKADINTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMRN 120
Cdd:pfam01929   1 RQVIPLKRLHLTKFVIKLPRGARTGAVKKAWEKADVDEKWAESAWAKKLAAREKRANLTDFDRFKVMVAKKQRR 74
KOW_RPL14 cd06088
KOW motif of Ribosomal Protein L14; RPL14 is a component of the large ribosomal subunit in ...
 7-81 1.28e-25

KOW motif of Ribosomal Protein L14; RPL14 is a component of the large ribosomal subunit in both archaea and eukaryotes with KOW motif at its N terminal. KOW domain is known as an RNA-binding motif that is shared so far among some families of ribosomal proteins, the essential bacterial transcriptional elongation factor NusG, the eukaryotic chromatin elongation factor Spt5, the higher eukaryotic KIN17 proteins and Mtr4. Auto-antibodies to RPL14 in humans have been associated with systemic lupus erythematosus . Although RPL14 is well conserved, it is not found in all archaea, and therefore it is presumably not essential.


Pssm-ID: 240512  Cd Length: 76  Bit Score: 94.85  E-value: 1.28e-25
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 78000181   7 VEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGPC-TQVRRQAMPFKCMQLTDFILKFPHSAHQKYVRQAWQKAD 81
Cdd:cd06088   1 VEIGRVVLSKAGRDKGKLYVIVDIIDENVVLVDGPLrTGVKPKKKNLKHLQLTDFVIDIPRGARTKGVKKANEKLR 76
valS PRK14900
valyl-tRNA synthetase; Provisional
 123-210 6.09e-09

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 55.38  E-value: 6.09e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181   123 IKNEVKKLQKAALLKASPKKAPGTKGTAAAAAAAaaaKVPAKKitAASKKAPAQKVPAQKATGQKAAPAPKAQKGQKAPA 202
Cdd:PRK14900  970 VAEAVRKTVRRSVKKAAATRAAMKKKVAKKAPAK---KAAAKK--AAAKKAAAKKKVAKKAPAKKVARKPAAKKAAKKPA 1044


                  ....*...
gi 78000181   203 QKAPAPKA 210
Cdd:PRK14900 1045 RKAAGRKA 1052
PRK04333 PRK04333
50S ribosomal protein L14e; Validated
 7-82 2.82e-08

50S ribosomal protein L14e; Validated


Pssm-ID: 235283  Cd Length: 84  Bit Score: 49.29  E-value: 2.82e-08
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 78000181    7 VEVGRVAYVSFGPHAGKLVAIVDVIDQNRALVDGP-CTQVRRQAMPFKCMQLTDFILKFPHSAHQKYVRQAWQKADI 82
Cdd:PRK04333   4 IEVGRVCVKTAGREAGRKCVIVDIIDKNFVLVTGPsLTGVKRRRCNIKHLEPTDKKVDIEKGASDEEVKKALEAAGL 80
valS PRK14900
valyl-tRNA synthetase; Provisional
 92-215 1.12e-05

valyl-tRNA synthetase; Provisional


Pssm-ID: 237855 [Multi-domain]  Cd Length: 1052  Bit Score: 45.75  E-value: 1.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181    92 AKKIEARERKAKMTDfDRFKVMKAKKMRNRIIKNEVKKLQKAALLKASPKKAPGTKGTAAAAAAAAAAKVPA-------- 163
Cdd:PRK14900  884 ARAEELREKRGKLEA-HRAMLSGSEANSARRDTMEIQNEQKPTQDGPAAEAQPAQENTVVESAEKAVAAVSEaaqqaata 962

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181   164 -----KKITAASKK---APAQKVPAQKATGQKAAPAPKAQKgqKAPAQKAPAPKASGKKA 215
Cdd:PRK14900  963 vasgiEKVAEAVRKtvrRSVKKAAATRAAMKKKVAKKAPAK--KAAAKKAAAKKAAAKKK 1020
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 139-215 2.09e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 38.72  E-value: 2.09e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 78000181   139 SPKKAPGTKGTAAAAAAAAAAKVPAKKITAASKKAPAQKVPAQKATGQKAAPAPKAQKGQKAPAQKAPAPKASGKKA 215
Cdd:PRK12270   37 GPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAV 113
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 138-210 2.26e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 38.72  E-value: 2.26e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 78000181   138 ASPKKAPGTKGTAAAAAAAAAAKVPAKKITAASKKAPAQKVPAQKATGQKAAPAPKAQKGQKAPAQKAPAPKA 210
Cdd:PRK12270   34 ADYGPGSTAAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAA 106
PRK13808 PRK13808
adenylate kinase; Provisional
 83-211 5.27e-03

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 37.17  E-value: 5.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181   83 NTKWAATRWAKKIEARERKAKMTDFDRFKVMKAKKMRNRIIKNEVKKLQKAALLKASPKKAPGTKGTAAAAAAAAAAKVP 162
Cdd:PRK13808 198 NAKKAAKTPAAKSGAKKASAKAKSAAKKVSKKKAAKTAVSAKKAAKTAAKAAKKAKKTAKKALKKAAKAVKKAAKKAAKA 277

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 78000181  163 AKKITAASKKAPAQKVPAQKATGQKAAPAPKAQKGQKAPAQKAPAPKAS 211
Cdd:PRK13808 278 AAKAAKGAAKATKGKAKAKKKAGKKAAAGSKAKATAKAPKRGAKGKKAK 326
PRK10905 PRK10905
cell division protein DamX; Validated
 126-215 8.06e-03

cell division protein DamX; Validated


Pssm-ID: 236792 [Multi-domain]  Cd Length: 328  Bit Score: 36.45  E-value: 8.06e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181  126 EVKKLQKAAllKASPKKAPGTKGTAAAAAAAAAAKVPAKKITAASkKAPAQKVPAQKAtgqkaapapkaqkgqkAPAQKA 205
Cdd:PRK10905 164 EPKKPQATA--KTEPKPVAQTPKRTEPAAPVASTKAPAATSTPAP-KETATTAPVQTA----------------SPAQTT 224

                         90
                 ....*....|
gi 78000181  206 PAPKASGKKA 215
Cdd:PRK10905 225 ATPAAGGKTA 234
PTZ00144 PTZ00144
dihydrolipoamide succinyltransferase; Provisional
 160-215 8.72e-03

dihydrolipoamide succinyltransferase; Provisional


Pssm-ID: 240289 [Multi-domain]  Cd Length: 418  Bit Score: 36.58  E-value: 8.72e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 78000181  160 KVPAKKITAASKKAPAQKVPAQKATGQKAAPAPKAQKGQKAPAQKAPAPKASGKKA 215
Cdd:PTZ00144 123 APPAAAPAAAAAAKAEKTTPEKPKAAAPTPEPPAASKPTPPAAAKPPEPAPAAKPP 178
kgd PRK12270
multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine ...
 138-212 9.30e-03

multifunctional oxoglutarate decarboxylase/oxoglutarate dehydrogenase thiamine pyrophosphate-binding subunit/dihydrolipoyllysine-residue succinyltransferase subunit;


Pssm-ID: 237030 [Multi-domain]  Cd Length: 1228  Bit Score: 36.79  E-value: 9.30e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 78000181   138 ASPKKAPGTKGTAAAAAAAAAAKVPAKKITAASKKAPAQKVPAQKATGQKAAPAPKAQKGQKAPAQKAPAPKASG 212
Cdd:PRK12270   42 AAPTAAAAAAAAAASAPAAAPAAKAPAAPAPAPPAAAAPAAPPKPAAAAAAAAAPAAPPAAAAAAAPAAAAVEDE 116
PRK13808 PRK13808
adenylate kinase; Provisional
 129-215 9.63e-03

adenylate kinase; Provisional


Pssm-ID: 172341 [Multi-domain]  Cd Length: 333  Bit Score: 36.40  E-value: 9.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 78000181  129 KLQKAALLKASPKKAPGTKGTAAAAAAAAAAKVPAKKIT-AASKKAPAQKVPAQKATGQKAAPAPKAQKGQKAPAQKAPA 207
Cdd:PRK13808 204 KTPAAKSGAKKASAKAKSAAKKVSKKKAAKTAVSAKKAAkTAAKAAKKAKKTAKKALKKAAKAVKKAAKKAAKAAAKAAK 283


                 ....*...
gi 78000181  208 PKASGKKA 215
Cdd:PRK13808 284 GAAKATKG 291
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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