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Conserved domains on  [gi|4557040|ref|NP_003990|]
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oncostatin-M-specific receptor subunit beta isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LIFR_D2 super family cl39403
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 30-138 1.36e-23

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


The actual alignment was detected with superfamily member pfam17971:

Pssm-ID: 375455  Cd Length: 114  Bit Score: 96.37  E-value: 1.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040     30 LPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKW-NQVLHWSWESELPLECA 108
Cdd:pfam17971   5 IPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGkDTVHHWNWTSDMPLECT 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 4557040    109 THFVRIKSLVDDAKFPEPNFWSNWSSWEEV 138
Cdd:pfam17971  85 SHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 625-733 1.26e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 1.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040  625 PSDNPHVLVDTLTSHSFTLSWKdySTESQPGFIQGYHVYLKSKarqchprfekavlsDGSECCKYKIDNPEEKALIVDNL 704
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREK--------------GSGDWKEVEVTPGSETSYTLTGL 64

                        90       100
                ....*....|....*....|....*....
gi 4557040  705 KPESFYEFFITPFTSAGEGPSATFTKVTT 733
Cdd:cd00063  65 KPGTEYEFRVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
539-607 1.11e-05

Fibronectin type III domain;


:

Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.11e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4557040    539 TEGGFSLSWKP---QPGDVIGYVVDWcdHTQDVLGDFQWKNVGPNTTSTVIStdAFRPGVRYDFRIYGLSTK 607
Cdd:pfam00041  12 TSTSLTVSWTPppdGNGPITGYEVEY--RPKNSGEPWNEITVPGTTTSVTLT--GLKPGTEYEVRVQAVNGG 79
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 335-419 1.10e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040  335 NPFSVNFENVNATNAIMTWKV--HSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHf 412
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPpeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG- 81


                ....*..
gi 4557040  413 wkWSEWS 419
Cdd:cd00063  82 --ESPPS 86
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 233-288 1.89e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 38.94  E-value: 1.89e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4557040    233 VSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGwskqpsQSYTLFESFSGEK-KLC 288
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLP------TTYSFSYAYENETvKEC 54
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 445-521 2.07e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 2.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040  445 GNHTVTLFWKPLSklHANGKILFYNVVVENLDKPSSSELHsiPAPANSTKLILDR----CSYQICVIANNSVGASPASVI 520
Cdd:cd00063  13 TSTSVTLSWTPPE--DDGGPITGYVVEYREKGSGDWKEVE--VTPGSETSYTLTGlkpgTEYEFRVRAVNGGGESPPSES 88


                .
gi 4557040  521 V 521
Cdd:cd00063  89 V 89
 
Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 30-138 1.36e-23

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


Pssm-ID: 375455  Cd Length: 114  Bit Score: 96.37  E-value: 1.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040     30 LPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKW-NQVLHWSWESELPLECA 108
Cdd:pfam17971   5 IPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGkDTVHHWNWTSDMPLECT 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 4557040    109 THFVRIKSLVDDAKFPEPNFWSNWSSWEEV 138
Cdd:pfam17971  85 SHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 625-733 1.26e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 1.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040  625 PSDNPHVLVDTLTSHSFTLSWKdySTESQPGFIQGYHVYLKSKarqchprfekavlsDGSECCKYKIDNPEEKALIVDNL 704
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREK--------------GSGDWKEVEVTPGSETSYTLTGL 64

                        90       100
                ....*....|....*....|....*....
gi 4557040  705 KPESFYEFFITPFTSAGEGPSATFTKVTT 733
Cdd:cd00063  65 KPGTEYEFRVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
539-607 1.11e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.11e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4557040    539 TEGGFSLSWKP---QPGDVIGYVVDWcdHTQDVLGDFQWKNVGPNTTSTVIStdAFRPGVRYDFRIYGLSTK 607
Cdd:pfam00041  12 TSTSLTVSWTPppdGNGPITGYEVEY--RPKNSGEPWNEITVPGTTTSVTLT--GLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 625-723 6.91e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 6.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040     625 PSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQchprfEKAVLSDGSECckykidnpeekALIVDNL 704
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSE-----WKEVNVTPSST-----------SYTLTGL 64

                           90
                   ....*....|....*....
gi 4557040     705 KPESFYEFFITPFTSAGEG 723
Cdd:smart00060  65 KPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 335-419 1.10e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040  335 NPFSVNFENVNATNAIMTWKV--HSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHf 412
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPpeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG- 81


                ....*..
gi 4557040  413 wkWSEWS 419
Cdd:cd00063  82 --ESPPS 86
fn3 pfam00041
Fibronectin type III domain;
624-724 9.83e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 9.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040    624 APSDnphVLVDTLTSHSFTLSWKdySTESQPGFIQGYHVYLKSKarqchprfekavlsDGSECCKYKIDNPEEKALIVDN 703
Cdd:pfam00041   2 APSN---LTVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPK--------------NSGEPWNEITVPGTTTSVTLTG 62

                          90       100
                  ....*....|....*....|.
gi 4557040    704 LKPESFYEFFITPFTSAGEGP 724
Cdd:pfam00041  63 LKPGTEYEVRVQAVNGGGEGP 83
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 233-288 1.89e-03

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 38.94  E-value: 1.89e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4557040    233 VSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGwskqpsQSYTLFESFSGEK-KLC 288
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLP------TTYSFSYAYENETvKEC 54
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 445-521 2.07e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 2.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040  445 GNHTVTLFWKPLSklHANGKILFYNVVVENLDKPSSSELHsiPAPANSTKLILDR----CSYQICVIANNSVGASPASVI 520
Cdd:cd00063  13 TSTSVTLSWTPPE--DDGGPITGYVVEYREKGSGDWKEVE--VTPGSETSYTLTGlkpgTEYEFRVRAVNGGGESPPSES 88


                .
gi 4557040  521 V 521
Cdd:cd00063  89 V 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 539-602 2.12e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 2.12e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040  539 TEGGFSLSWKPQPGD---VIGYVVDWCDHTQDvlgdfQWKNVG---PNTTSTVIstDAFRPGVRYDFRIY 602
Cdd:cd00063  13 TSTSVTLSWTPPEDDggpITGYVVEYREKGSG-----DWKEVEvtpGSETSYTL--TGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 539-602 4.35e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.21  E-value: 4.35e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4557040     539 TEGGFSLSWKPQPGD-VIGYVVDWcdHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIY 602
Cdd:smart00060  13 TSTSVTLSWEPPPDDgITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
 
Name Accession Description Interval E-value
LIFR_D2 pfam17971
Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding ...
 30-138 1.36e-23

Leukemia inhibitory factor receptor D2 domain; This is the D2 domain in cytokine-binding module 1 (CBM1) found in Leukemia inhibitory factor receptor (LIFR) and OSM receptors (OSMR). LIFR has an extracellular region with a modular structure containing two cytokine-binding modules (CBM) separated by an Ig-like domain and followed by three membrane-proximal fibronectin type-III (FNIII) domains. The D2 domain in CBM1 shows structural similarity to the corresponding CBM domains of both gp130 and IL-6Ralpha because it contains conserved structural features like the WSXWS motif. The WSXWS motif in cytokine receptors is a molecular switch involved in receptor activation.


Pssm-ID: 375455  Cd Length: 114  Bit Score: 96.37  E-value: 1.36e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040     30 LPLTPVSLKVSTNSTRQSLHLQWTVHNLPYHQELKMVFQIQISRIETSNVIWVGNYSTTVKW-NQVLHWSWESELPLECA 108
Cdd:pfam17971   5 IPDTPQILNLTADFSTSTLHLKWNDKGSAFPYHSNVIWEIKVLRKEKMEIVTLVTYNTTLNGkDTVHHWNWTSDMPLECT 84

                          90       100       110
                  ....*....|....*....|....*....|
gi 4557040    109 THFVRIKSLVDDAKFPEPNFWSNWSSWEEV 138
Cdd:pfam17971  85 SHSVRIRCYIDDVHFSGPKEWSEWSPLKNI 114
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 625-733 1.26e-08

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 53.27  E-value: 1.26e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040  625 PSDNPHVLVDTLTSHSFTLSWKdySTESQPGFIQGYHVYLKSKarqchprfekavlsDGSECCKYKIDNPEEKALIVDNL 704
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWT--PPEDDGGPITGYVVEYREK--------------GSGDWKEVEVTPGSETSYTLTGL 64

                        90       100
                ....*....|....*....|....*....
gi 4557040  705 KPESFYEFFITPFTSAGEGPSATFTKVTT 733
Cdd:cd00063  65 KPGTEYEFRVRAVNGGGESPPSESVTVTT 93
fn3 pfam00041
Fibronectin type III domain;
539-607 1.11e-05

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 44.71  E-value: 1.11e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4557040    539 TEGGFSLSWKP---QPGDVIGYVVDWcdHTQDVLGDFQWKNVGPNTTSTVIStdAFRPGVRYDFRIYGLSTK 607
Cdd:pfam00041  12 TSTSLTVSWTPppdGNGPITGYEVEY--RPKNSGEPWNEITVPGTTTSVTLT--GLKPGTEYEVRVQAVNGG 79
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 625-723 6.91e-05

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 42.22  E-value: 6.91e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040     625 PSDNPHVLVDTLTSHSFTLSWKDYSTESQPGFIQGYHVYLKSKARQchprfEKAVLSDGSECckykidnpeekALIVDNL 704
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSE-----WKEVNVTPSST-----------SYTLTGL 64

                           90
                   ....*....|....*....
gi 4557040     705 KPESFYEFFITPFTSAGEG 723
Cdd:smart00060  65 KPGTEYEFRVRAVNGAGEG 83
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 335-419 1.10e-04

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 42.10  E-value: 1.10e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040  335 NPFSVNFENVNATNAIMTWKV--HSIRNNFTYLCQIELHGEGKMMQYNVSIKVNGEYFLSELEPATEYMARVRCADASHf 412
Cdd:cd00063   3 PPTNLRVTDVTSTSVTLSWTPpeDDGGPITGYVVEYREKGSGDWKEVEVTPGSETSYTLTGLKPGTEYEFRVRAVNGGG- 81


                ....*..
gi 4557040  413 wkWSEWS 419
Cdd:cd00063  82 --ESPPS 86
fn3 pfam00041
Fibronectin type III domain;
624-724 9.83e-04

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 38.94  E-value: 9.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040    624 APSDnphVLVDTLTSHSFTLSWKdySTESQPGFIQGYHVYLKSKarqchprfekavlsDGSECCKYKIDNPEEKALIVDN 703
Cdd:pfam00041   2 APSN---LTVTDVTSTSLTVSWT--PPPDGNGPITGYEVEYRPK--------------NSGEPWNEITVPGTTTSVTLTG 62

                          90       100
                  ....*....|....*....|.
gi 4557040    704 LKPESFYEFFITPFTSAGEGP 724
Cdd:pfam00041  63 LKPGTEYEVRVQAVNGGGEGP 83
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 233-288 1.89e-03

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 38.94  E-value: 1.89e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4557040    233 VSKVLEEPKDFSCETEDFKTLHCTWDPGTDTALGwskqpsQSYTLFESFSGEK-KLC 288
Cdd:pfam09067   4 ALLLPEKPEDIKCFSREKEDFTCFWEEEEDGGLP------TTYSFSYAYENETvKEC 54
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 445-521 2.07e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 2.07e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040  445 GNHTVTLFWKPLSklHANGKILFYNVVVENLDKPSSSELHsiPAPANSTKLILDR----CSYQICVIANNSVGASPASVI 520
Cdd:cd00063  13 TSTSVTLSWTPPE--DDGGPITGYVVEYREKGSGDWKEVE--VTPGSETSYTLTGlkpgTEYEFRVRAVNGGGESPPSES 88


                .
gi 4557040  521 V 521
Cdd:cd00063  89 V 89
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 539-602 2.12e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 38.25  E-value: 2.12e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4557040  539 TEGGFSLSWKPQPGD---VIGYVVDWCDHTQDvlgdfQWKNVG---PNTTSTVIstDAFRPGVRYDFRIY 602
Cdd:cd00063  13 TSTSVTLSWTPPEDDggpITGYVVEYREKGSG-----DWKEVEvtpGSETSYTL--TGLKPGTEYEFRVR 75
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 539-602 4.35e-03

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 37.21  E-value: 4.35e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4557040     539 TEGGFSLSWKPQPGD-VIGYVVDWcdHTQDVLGDFQWKNVGPNTTSTVISTDAFRPGVRYDFRIY 602
Cdd:smart00060  13 TSTSVTLSWEPPPDDgITGYIVGY--RVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVR 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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