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Conserved domains on  [gi|4758384|ref|NP_004108|]
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peptidyl-prolyl cis-trans isomerase FKBP5 isoform 1 [Homo sapiens]

Protein Classification

FKBP_C and TPR domain-containing protein( domain architecture ID 11991378)

FKBP_C and TPR domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-135 3.97e-40

FKBP-type peptidyl-prolyl cis-trans isomerase;


:

Pssm-ID: 459735  Cd Length: 94  Bit Score: 138.87  E-value: 3.97e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384     43 GEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLP-K 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGpV 80

                          90
                  ....*....|....
gi 4758384    122 IPSNATLFFEIELL 135
Cdd:pfam00254  81 IPPNATLVFEVELL 94
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
266-403 1.65e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 1.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  266 EQAAIVKEKGTVYFKGGKYMQAVIQYGKIvswLEMEYGLSEkeskasesfllaAFLNLAMCYLKLREYTKAVECCDKALG 345
Cdd:COG0457   6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKA---LELDPDDAE------------ALYNLGLAYLRLGRYEEALADYEQALE 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4758384  346 LDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG0457  71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-135 3.97e-40

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 138.87  E-value: 3.97e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384     43 GEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLP-K 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGpV 80

                          90
                  ....*....|....
gi 4758384    122 IPSNATLFFEIELL 135
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 36-137 5.90e-40

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 138.78  E-value: 5.90e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384   36 IVKRVGNGEEtPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGS 115
Cdd:COG0545   4 KVLKEGTGAK-PKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGE 82

                        90       100
                ....*....|....*....|..
gi 4758384  116 AGSLPKIPSNATLFFEIELLDF 137
Cdd:COG0545  83 RGAGGVIPPNSTLVFEVELLDV 104
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 7-138 6.57e-23

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 97.91  E-value: 6.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384     7 AKNNEESPTATVAEQGEDITSKK-DRGVLKIVKRVGNGEeTPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKgq 85
Cdd:PRK10902 121 AADNEAKGKKYREKFAKEKGVKTtSTGLLYKVEKEGTGE-APKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG-- 197

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 4758384    86 VIKAWDIGVATMKKGEICHLLCKPEYAYGSAGsLPKIPSNATLFFEIELLDFK 138
Cdd:PRK10902 198 VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAG-VPGIPANSTLVFDVELLDVK 249
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
266-403 1.65e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 1.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  266 EQAAIVKEKGTVYFKGGKYMQAVIQYGKIvswLEMEYGLSEkeskasesfllaAFLNLAMCYLKLREYTKAVECCDKALG 345
Cdd:COG0457   6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKA---LELDPDDAE------------ALYNLGLAYLRLGRYEEALADYEQALE 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4758384  346 LDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG0457  71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 230-397 2.64e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 56.15  E-value: 2.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384    230 KPKF-GIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEY-GLSEK 307
Cdd:TIGR00990 274 KPRPaGLEDSNELDEETGNGQLQLGLKSPESKADESYEEAARAFEKALDLGKLGEKEAIALNLRGTFKCLKGKHlEALAD 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384    308 ESKASESF--LLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNK 385
Cdd:TIGR00990 354 LSKSIELDprVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFI 433

                         170
                  ....*....|..
gi 4758384    386 AARLQISMCQKK 397
Cdd:TIGR00990 434 FSHIQLGVTQYK 445
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 319-350 8.95e-06

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 42.43  E-value: 8.95e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4758384     319 AFLNLAMCYLKLREYTKAVECCDKALGLDSAN 350
Cdd:smart00028   3 ALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
319-347 1.56e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 41.64  E-value: 1.56e-05
                          10        20
                  ....*....|....*....|....*....
gi 4758384    319 AFLNLAMCYLKLREYTKAVECCDKALGLD 347
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELN 31
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 305-403 1.77e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 46.70  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384   305 SEKESKASESFL-----LAA----------------FLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLL 363
Cdd:PLN03088   3 KDLEDKAKEAFVdddfaLAVdlytqaidldpnnaelYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMK 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 4758384   364 MNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:PLN03088  83 LEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAEEEK 122
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 318-382 4.46e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 42.23  E-value: 4.46e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4758384  318 AAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNP 382
Cdd:cd24142   1 DELLEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDP 65
 
Name Accession Description Interval E-value
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
43-135 3.97e-40

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 138.87  E-value: 3.97e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384     43 GEETPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLP-K 121
Cdd:pfam00254   1 GPEKAKKGDRVTVHYTGTLEDGTVFDSSYDRGKPFEFTLGSGQVIPGWDEGLVGMKVGEKRKLTIPPELAYGEEGLAGpV 80

                          90
                  ....*....|....
gi 4758384    122 IPSNATLFFEIELL 135
Cdd:pfam00254  81 IPPNATLVFEVELL 94
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 36-137 5.90e-40

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 138.78  E-value: 5.90e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384   36 IVKRVGNGEEtPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGS 115
Cdd:COG0545   4 KVLKEGTGAK-PKAGDTVTVHYTGTLLDGTVFDSSYDRGEPATFPLGVGQVIPGWDEGLQGMKVGGKRRLVIPPELAYGE 82

                        90       100
                ....*....|....*....|..
gi 4758384  116 AGSLPKIPSNATLFFEIELLDF 137
Cdd:COG0545  83 RGAGGVIPPNSTLVFEVELLDV 104
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 7-138 6.57e-23

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 97.91  E-value: 6.57e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384     7 AKNNEESPTATVAEQGEDITSKK-DRGVLKIVKRVGNGEeTPMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKgq 85
Cdd:PRK10902 121 AADNEAKGKKYREKFAKEKGVKTtSTGLLYKVEKEGTGE-APKDSDTVVVNYKGTLIDGKEFDNSYTRGEPLSFRLDG-- 197

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 4758384    86 VIKAWDIGVATMKKGEICHLLCKPEYAYGSAGsLPKIPSNATLFFEIELLDFK 138
Cdd:PRK10902 198 VIPGWTEGLKNIKKGGKIKLVIPPELAYGKAG-VPGIPANSTLVFDVELLDVK 249
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
266-403 1.65e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 1.65e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  266 EQAAIVKEKGTVYFKGGKYMQAVIQYGKIvswLEMEYGLSEkeskasesfllaAFLNLAMCYLKLREYTKAVECCDKALG 345
Cdd:COG0457   6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKA---LELDPDDAE------------ALYNLGLAYLRLGRYEEALADYEQALE 70

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 4758384  346 LDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG0457  71 LDPDDAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLALLELGRYDE 128
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 47-136 3.32e-12

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 65.59  E-value: 3.32e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384    47 PMIGDKVYVHYKGKLSNGKKFDSSHDRNEPFVFSLGKgqVIKAWDIGVATMKKGEICHLLCKPEYAYGSAGSLPKIPSNA 126
Cdd:PRK11570 117 PARTDRVRVHYTGKLIDGTVFDSSVARGEPAEFPVNG--VIPGWIEALTLMPVGSKWELTIPHELAYGERGAGASIPPFS 194

                         90
                 ....*....|
gi 4758384   127 TLFFEIELLD 136
Cdd:PRK11570 195 TLVFEVELLE 204
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 250-403 6.10e-11

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 62.82  E-value: 6.10e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  250 FEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVswlemeyglsekeskASESFLLAAFLNLAMCYLK 329
Cdd:COG2956  58 YDRAIRIHQKLLERDPDRAEALLELAQDYLKAGLLDRAEELLEKLL---------------ELDPDDAEALRLLAEIYEQ 122

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4758384  330 LREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG2956 123 EGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEE 196
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 319-403 1.08e-10

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 59.25  E-value: 1.08e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  319 AFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKA 398
Cdd:COG4235  19 GWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQ 98


                ....*
gi 4758384  399 KEHNE 403
Cdd:COG4235  99 GDYAE 103
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 315-403 4.06e-10

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 58.43  E-value: 4.06e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  315 FLLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMC 394
Cdd:COG5010  52 KAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAAL 131


                ....*....
gi 4758384  395 QKKAKEHNE 403
Cdd:COG5010 132 LLSLGQDDE 140
SlpA COG1047
Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein ...
 50-150 4.09e-10

Peptidyl-prolyl cis-trans isomerase, FKBP type [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440668 [Multi-domain]  Cd Length: 138  Bit Score: 57.80  E-value: 4.09e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384   50 GDKVYVHYKGKLSNGKKFDSSHDRnEPFVFSLGKGQVIKAWDIGVATMKKGEICHLLCKPEYAYGsagslpkiPSNATLF 129
Cdd:COG1047   4 GDVVTLHYTLKLEDGEVFDSTFEG-EPLEFLHGAGQLIPGLEEALEGMEVGDKKTVTLPPEEAYG--------ERDPELV 74

                        90       100
                ....*....|....*....|.
gi 4758384  130 FEIELLDFKGEDLFEDGGIIR 150
Cdd:COG1047  75 QTVPREQFPEDEELEVGMQVE 95
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
266-406 5.26e-10

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 59.16  E-value: 5.26e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  266 EQAAIVKEKGTVYFKGGKYMQAVIQYGKIvswLEMEYGLSEkeskasesfllaAFLNLAMCYLKLREYTKAVECCDKALG 345
Cdd:COG4785  71 DLAQLYYERGVAYDSLGDYDLAIADFDQA---LELDPDLAE------------AYNNRGLAYLLLGDYDAALEDFDRALE 135

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758384  346 LDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDR 406
Cdd:COG4785 136 LDPDYAYAYLNRGIALYYLGRYELAIADLEKALELDPNDPERALWLYLAERKLDPEKALAL 196
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
247-428 8.58e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 58.86  E-value: 8.58e-10
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  247 LKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIvswLEMEYGLSEkeskasesfllaAFLNLAMC 326
Cdd:COG0457  55 LGRYEEALADYEQALELDPDDAEALNNLGLALQALGRYEEALEDYDKA---LELDPDDAE------------ALYNLGLA 119

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  327 YLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDR 406
Cdd:COG0457 120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                       170       180
                ....*....|....*....|..
gi 4758384  407 RIYANMFKKFAEQDAKEEANKA 428
Cdd:COG0457 200 LLALEQALRKKLAILTLAALAE 221
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 275-389 1.91e-09

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 55.78  E-value: 1.91e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  275 GTVYFKGGKYMQAVIQYGKIVSwlemeygLSEKESkasesfllAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGL 354
Cdd:COG4235  24 GRAYLRLGRYDEALAAYEKALR-------LDPDNA--------DALLDLAEALLAAGDTEEAEELLERALALDPDNPEAL 88

                        90       100       110
                ....*....|....*....|....*....|....*
gi 4758384  355 YRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARL 389
Cdd:COG4235  89 YLLGLAAFQQGDYAEAIAAWQKLLALLPADAPARL 123
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 250-431 1.17e-08

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 55.89  E-value: 1.17e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  250 FEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIvswlemeyglsEKESKASESFLLaaflNLAMCYLK 329
Cdd:COG2956  92 LDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEKAIEVLERL-----------LKLGPENAHAYC----ELAELYLE 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  330 LREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNErdrriY 409
Cdd:COG2956 157 QGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEE-----A 231

                       170       180
                ....*....|....*....|..
gi 4758384  410 ANMFKKFAEQDAKEEANKAMGK 431
Cdd:COG2956 232 LELLRKALELDPSDDLLLALAD 253
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 318-403 1.40e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 53.27  E-value: 1.40e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  318 AAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKK 397
Cdd:COG4783  39 EAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRA 118


                ....*.
gi 4758384  398 AKEHNE 403
Cdd:COG4783 119 LGRPDE 124
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 263-382 2.20e-08

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 53.43  E-value: 2.20e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  263 EKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSwlemeygLSEKESkasesfllAAFLNLAMCYLKLREYTKAVECCDK 342
Cdd:COG5010  49 KLAKAFAIESPSDNLYNKLGDFEESLALLEQALQ-------LDPNNP--------ELYYNLALLYSRSGDKDEAKEYYEK 113

                        90       100       110       120
                ....*....|....*....|....*....|....*....|
gi 4758384  343 ALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNP 382
Cdd:COG5010 114 ALALSPDNPNAYSNLAALLLSLGQDDEAKAALQRALGTSP 153
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 275-406 2.58e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 56.15  E-value: 2.58e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  275 GTVYFKGGKYMQAVIQYGKIvswLEMEYGLSEkeskasesfllaAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGL 354
Cdd:COG3914 119 GNLLLALGRLEEALAALRRA---LALNPDFAE------------AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEAL 183

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|..
gi 4758384  355 YRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDR 406
Cdd:COG3914 184 NNLGNALQDLGRLEEAIAAYRRALELDPDNADAHSNLLFALRQACDWEVYDR 235
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 230-397 2.64e-08

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 56.15  E-value: 2.64e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384    230 KPKF-GIEPNAELIYEVTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVSWLEMEY-GLSEK 307
Cdd:TIGR00990 274 KPRPaGLEDSNELDEETGNGQLQLGLKSPESKADESYEEAARAFEKALDLGKLGEKEAIALNLRGTFKCLKGKHlEALAD 353

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384    308 ESKASESF--LLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNK 385
Cdd:TIGR00990 354 LSKSIELDprVTQSYIKRASMNLELGDPDKAEEDFDKALKLNSEDPDIYYHRAQLHFIKGEFAQAGKDYQKSIDLDPDFI 433

                         170
                  ....*....|..
gi 4758384    386 AARLQISMCQKK 397
Cdd:TIGR00990 434 FSHIQLGVTQYK 445
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 317-403 3.63e-08

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 55.77  E-value: 3.63e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  317 LAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQK 396
Cdd:COG3914 112 AEALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQ 191


                ....*..
gi 4758384  397 KAKEHNE 403
Cdd:COG3914 192 DLGRLEE 198
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 274-384 5.39e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 51.73  E-value: 5.39e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  274 KGTVYFKGGKYMQAVIQYGKIVSwlemeygLSEKESkasesfllAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKG 353
Cdd:COG4783  44 LGEILLQLGDLDEAIVLLHEALE-------LDPDEP--------EARLNLGLALLKAGDYDEALALLEKALKLDPEHPEA 108

                        90       100       110
                ....*....|....*....|....*....|.
gi 4758384  354 LYRRGEAQLLMNEFESAKGDFEKVLEVNPQN 384
Cdd:COG4783 109 YLRLARAYRALGRPDEAIAALEKALELDPDD 139
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 317-403 8.98e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.96  E-value: 8.98e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  317 LAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQK 396
Cdd:COG4783   4 AEALYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALL 83


                ....*..
gi 4758384  397 KAKEHNE 403
Cdd:COG4783  84 KAGDYDE 90
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
326-403 9.89e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 49.78  E-value: 9.89e-08
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4758384  326 CYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKgDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG3063   1 LYLKLGDLEEAEEYYEKALELDPDNADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYDE 77
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 248-393 2.19e-07

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 53.55  E-value: 2.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384    248 KSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVswlemeyglsekesKASESFLLAAFLnLAMCY 327
Cdd:TIGR02917 275 KNYEDARETLQDALKSAPEYLPALLLAGASEYQLGNLEQAYQYLNQIL--------------KYAPNSHQARRL-LASIQ 339

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4758384    328 LKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISM 393
Cdd:TIGR02917 340 LRLGRVDEAIATLSPALGLDPDDPAALSLLGEAYLALGDFEKAAEYLAKATELDPENAAARTQLGI 405
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 277-403 4.69e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 4.69e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  277 VYFKGGKYMQAVIqygkivswlemeYGLSEKESKASESFL---------LAAFLNLAMCYLKLREYTKAVECCDKALGLD 347
Cdd:COG2956   5 VAAALGWYFKGLN------------YLLNGQPDKAIDLLEealeldpetVEAHLALGNLYRRRGEYDRAIRIHQKLLERD 72

                        90       100       110       120       130
                ....*....|....*....|....*....|....*....|....*....|....*.
gi 4758384  348 SANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG2956  73 PDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDAEALRLLAEIYEQEGDWEK 128
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
319-382 1.30e-06

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 46.32  E-value: 1.30e-06
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 4758384  319 AFLNLAMCYLKLREYTKAVECcDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNP 382
Cdd:COG3063  28 ALNNLGLLLLEQGRYDEAIAL-EKALKLDPNNAEALLNLAELLLELGDYDEALAYLERALELDP 90
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 242-384 4.31e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.19  E-value: 4.31e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  242 IYEvTLKSFEKAKESWEMDTKEKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVswlemeyglsekeskASESFLLAAFL 321
Cdd:COG2956 119 IYE-QEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGDYDEAIEALEKAL---------------KLDPDCARALL 182

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4758384  322 NLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQN 384
Cdd:COG2956 183 LLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAELYEKLGDPEEALELLRKALELDPSD 245
CpoB COG1729
Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane ...
 278-389 4.79e-06

Cell division protein CpoB, coordinates peptidoglycan biosynthesis and outer membrane constriction [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 441335 [Multi-domain]  Cd Length: 113  Bit Score: 45.37  E-value: 4.79e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384  278 YFKGGKYMQAVIQYGKIVSwlemeyglsekesKASESFLLA-AFLNLAMCYLKLREYTKAVECCDKALGLDSANEK---G 353
Cdd:COG1729   3 LLKAGDYDEAIAAFKAFLK-------------RYPNSPLAPdALYWLGEAYYALGDYDEAAEAFEKLLKRYPDSPKapdA 69

                        90       100       110
                ....*....|....*....|....*....|....*.
gi 4758384  354 LYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARL 389
Cdd:COG1729  70 LLKLGLSYLELGDYDKARATLEELIKKYPDSEAAKE 105
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 319-350 8.95e-06

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 42.43  E-value: 8.95e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 4758384     319 AFLNLAMCYLKLREYTKAVECCDKALGLDSAN 350
Cdd:smart00028   3 ALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
319-347 1.56e-05

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 41.64  E-value: 1.56e-05
                          10        20
                  ....*....|....*....|....*....
gi 4758384    319 AFLNLAMCYLKLREYTKAVECCDKALGLD 347
Cdd:pfam00515   3 ALYNLGNAYFKLGKYDEALEYYEKALELN 31
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 305-403 1.77e-05

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 46.70  E-value: 1.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384   305 SEKESKASESFL-----LAA----------------FLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLL 363
Cdd:PLN03088   3 KDLEDKAKEAFVdddfaLAVdlytqaidldpnnaelYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRKGTACMK 82

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 4758384   364 MNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:PLN03088  83 LEEYQTAKAALEKGASLAPGDSRFTKLIKECDEKIAEEEK 122
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 335-403 4.27e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.07  E-value: 4.27e-05
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 4758384  335 KAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNE 403
Cdd:COG4235   1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEE 69
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 263-423 1.68e-04

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 44.20  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384    263 EKLEQAAIVKEKGTVYFKGGKYMQAVIQYGKIVswlemeyglsekESKASESFllaaFLNLAMCYLKLREYTKAVECCDK 342
Cdd:TIGR00990 122 ERKKYAAKLKEKGNKAYRNKDFNKAIKLYSKAI------------ECKPDPVY----YSNRAACHNALGDWEKVVEDTTA 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384    343 ALGLDSANEKGLYRRGEAQLLMNEFESAKGDFeKVLEVNPQNKaarlqismcqkkakehNERDRRIYANMFKKFAEQDAK 422
Cdd:TIGR00990 186 ALELDPDYSKALNRRANAYDGLGKYADALLDL-TASCIIDGFR----------------NEQSAQAVERLLKKFAESKAK 248


                  .
gi 4758384    423 E 423
Cdd:TIGR00990 249 E 249
TPR_1 pfam00515
Tetratricopeptide repeat;
352-384 2.07e-04

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 38.56  E-value: 2.07e-04
                          10        20        30
                  ....*....|....*....|....*....|...
gi 4758384    352 KGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQN 384
Cdd:pfam00515   2 KALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
ACL4-like cd24142
Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 ...
 318-382 4.46e-04

Assembly chaperone of ribosomal protein L4 and similar proteins; Assembly chaperone of RPL4 (ACL4) acts as a chaperone for the L4 ribosomal subunit, encoded by RPL4A and RPL4B, and is required for hierarchical ribosome assembly. It is required for the soluble expression of newly synthesized RPL4 and for the protection of RPL4 from the Tom1-dependent cellular degradation machinery. ACL4 shields ribosomal protein L4 until timely release and insertion into the pre-ribosome is possible, once ribosomal protein L18 is present.


Pssm-ID: 467942 [Multi-domain]  Cd Length: 306  Bit Score: 42.23  E-value: 4.46e-04
                        10        20        30        40        50        60
                ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4758384  318 AAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNP 382
Cdd:cd24142   1 DELLEKAEELLDQGNFELALKFLQRALELEPNNVEALELLGEILLELGDVEEAREVLLRAIELDP 65
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 295-400 6.51e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 6.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384    295 VSWLEMEYGLSEKEskasesflLAAFLNLAMCYLKLREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDF 374
Cdd:TIGR02917 553 VAWLEKAAELNPQE--------IEPALALAQYYLGKGQLKKALAILNEAADAAPDSPEAWLMLGRAQLAAGDLNKAVSSF 624

                          90       100
                  ....*....|....*....|....*.
gi 4758384    375 EKVLEVNPQNKAARLQISMCQKKAKE 400
Cdd:TIGR02917 625 KKLLALQPDSALALLLLADAYAVMKN 650
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 281-429 6.68e-04

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 42.38  E-value: 6.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384    281 GGKYMQAVIQYGKIVSWLEMEYGLSEKESKASESFLLAAFLN-------LAMCYLKL--REYTKAVECCDKALGLDSANE 351
Cdd:TIGR02917 114 PGKTLLDDEGAAELLALRGLAYLGLGQLELAQKSYEQALAIDprslyakLGLAQLALaeNRFDEARALIDEVLTADPGNV 193

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4758384    352 KGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQISMCQKKAKEHNERDRriYANMFKKFAEQDAKEEANKAM 429
Cdd:TIGR02917 194 DALLLKGDLLLSLGNIELALAAYRKAIALRPNNIAVLLALATILIEAGEFEEAEK--HADALLKKAPNSPLAHYLKAL 269
TPR_12 pfam13424
Tetratricopeptide repeat;
315-383 7.02e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 38.14  E-value: 7.02e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4758384    315 FLLAAFLNLAMCYLKLREYTKAVECCDKAL-------GLDSANEKGLYRR-GEAQLLMNEFESAKGDFEKVLEVNPQ 383
Cdd:pfam13424   1 DVATALNNLAAVLRRLGRYDEALELLEKALeiarrllGPDHPLTATTLLNlGRLYLELGRYEEALELLERALALAEK 77
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 352-384 9.23e-04

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.66  E-value: 9.23e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 4758384     352 KGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQN 384
Cdd:smart00028   2 EALYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
PRK15359 PRK15359
type III secretion system chaperone protein SscB; Provisional
 260-381 1.74e-03

type III secretion system chaperone protein SscB; Provisional


Pssm-ID: 185257 [Multi-domain]  Cd Length: 144  Bit Score: 38.83  E-value: 1.74e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758384   260 DTKEKLEQAAI----------VKEKGTVYFKGGKYMQAVIQYgkivSWLEMeyglsekeskaSESFLLAAFLNLAMCYLK 329
Cdd:PRK15359   6 DQKNKIPEDILkqllsvdpetVYASGYASWQEGDYSRAVIDF----SWLVM-----------AQPWSWRAHIALAGTWMM 70

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4758384   330 LREYTKAVECCDKALGLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVN 381
Cdd:PRK15359  71 LKEYTTAINFYGHALMLDASHPEPVYQTGVCLKMMGEPGLAREAFQTAIKMS 122
COG4700 COG4700
Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];
320-391 3.43e-03

Uncharacterized conserved protein ECs_4300, contains TPR-like domain [Function unknown];


Pssm-ID: 443735 [Multi-domain]  Cd Length: 249  Bit Score: 39.09  E-value: 3.43e-03
                        10        20        30        40        50        60        70
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4758384  320 FLNLAMCYLKLREYTKAVECCDKAL-GLDSANEKGLYRRGEAQLLMNEFESAKGDFEKVLEVNPQNKAARLQI 391
Cdd:COG4700  92 RVRLADALLELGRYDEAIELYEEALtGIFADDPHILLGLAQALFELGRYAEALETLEKLIAKNPDFKSSDAHL 164
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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