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Conserved domains on  [gi|117553627|ref|NP_004183|]
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probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein isoform 1 [Homo sapiens]

Protein Classification

bifunctional NTP pyrophosphatase/methyltransferase( domain architecture ID 10833645)

bifunctional nucleoside triphosphate (NTP) pyrophosphatase/methyltransferase, such as human probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein that contains an N-terminal nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP and a C-terminal class I SAM-dependent methyltransferase that may catalyze the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

CATH:  3.90.950.10|2.20.25.110
EC:  3.6.1.9|2.1.1.-
Gene Ontology:  GO:0047429|GO:0009146|GO:0000166|GO:1904047|GO:0008168
PubMed:  12826405|12504684
SCOP:  4000518|3000118

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Maf cd00555
Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in ...
 15-208 2.92e-81

Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or nucleic acid-binding protein with structural similarity to the hypoxanthine/xanthine NTP pyrophosphatase Ham1 from Methanococcus jannaschii, RNase H from Escherichia coli, and some other nucleotide or RNA-binding proteins.


:

Pssm-ID: 238310  Cd Length: 180  Bit Score: 253.55  E-value: 2.92e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  15 VVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLyqkdlRAPDVVIGADTIVTVG 94
Cdd:cd00555    1 LILASASPRRRELLEQLGIPFEVVPSDIDETPIKGE--SPEDYVLRLAEAKAEAVAARL-----PPDALVIGADTVVVLD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  95 GLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCsskdhqlDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAG 174
Cdd:cd00555   74 GRILGKPKDREEAREMLKRLSGRTHEVYTGVALIDP-------GGKLVTDVESTKVRFRELSDEEIEAYVASGEPLDKAG 146

                        170       180       190
                 ....*....|....*....|....*....|....
gi 117553627 175 GYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQL 208
Cdd:cd00555  147 AYGIQGLGGALIERIEGDYSNVVGLPLPELLKLL 180
AdoMet_MTases super family cl17173
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 388-599 3.60e-62

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


The actual alignment was detected with superfamily member pfam00891:

Pssm-ID: 473071 [Multi-domain]  Cd Length: 208  Bit Score: 204.95  E-value: 3.60e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  388 FTYLEFAIREGTNQHHRALGKKAedlfQDAYYQSPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALAR 467
Cdd:pfam00891   1 WRYLADAVREGRNQYNKAFGISL----FEAIYRDEEERLLFNRGLQEHWSLIGKDVLTAFDLSGFRSLVDVGGGTGALAQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  468 ELAREYPRMQVTVFDLPDIIELA-AHFQPPGPQAVQIHfaAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLSRVAESC 546
Cdd:pfam00891  77 AIVSLYPGCKGIVFDLPHVVEAApTHFSAGEEPRVTFH--GGDFFKDSLPEADAYILKRVLHDWSDEKCVKLLKRCYKAC 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 117553627  547 KPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGF 599
Cdd:pfam00891 155 PAGGKVILVESLLGADPSGPLHTQLYSLNMLAQTEGRERTEAEYSELLTGAGF 207
dimerization2 pfam16864
dimerization domain; This domain, found in methyltransferases, functions as a dimerization ...
 288-371 2.15e-32

dimerization domain; This domain, found in methyltransferases, functions as a dimerization domain.


:

Pssm-ID: 465287  Cd Length: 87  Bit Score: 119.59  E-value: 2.15e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  288 LLELIEGFMLSKGLLTACKLKVFDLLKdEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQ----GYSNTETANV 363
Cdd:pfam16864   1 LLDLIDGFRASKVLFTACELGVFDLLA-EGPLSAEEVAARLGASVDGTERLLDACVALGLLEREKTdgkgLYSNTELAST 79


                  ....*...
gi 117553627  364 YLASDGEY 371
Cdd:pfam16864  80 YLVSSSPK 87
 
Name Accession Description Interval E-value
Maf cd00555
Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in ...
 15-208 2.92e-81

Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or nucleic acid-binding protein with structural similarity to the hypoxanthine/xanthine NTP pyrophosphatase Ham1 from Methanococcus jannaschii, RNase H from Escherichia coli, and some other nucleotide or RNA-binding proteins.


Pssm-ID: 238310  Cd Length: 180  Bit Score: 253.55  E-value: 2.92e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  15 VVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLyqkdlRAPDVVIGADTIVTVG 94
Cdd:cd00555    1 LILASASPRRRELLEQLGIPFEVVPSDIDETPIKGE--SPEDYVLRLAEAKAEAVAARL-----PPDALVIGADTVVVLD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  95 GLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCsskdhqlDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAG 174
Cdd:cd00555   74 GRILGKPKDREEAREMLKRLSGRTHEVYTGVALIDP-------GGKLVTDVESTKVRFRELSDEEIEAYVASGEPLDKAG 146

                        170       180       190
                 ....*....|....*....|....*....|....
gi 117553627 175 GYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQL 208
Cdd:cd00555  147 AYGIQGLGGALIERIEGDYSNVVGLPLPELLKLL 180
Maf pfam02545
Maf-like protein; Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and ...
 15-211 8.17e-73

Maf-like protein; Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and archaea.


Pssm-ID: 460586  Cd Length: 174  Bit Score: 231.52  E-value: 8.17e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627   15 VVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASfATPYGYAMETAKQKALevanrlyqkdlrapDVVIGADTIVTvg 94
Cdd:pfam02545   1 LILASASPRRRELLEQLGIEFEVVPSDIDETPLKED-PAPEEYVLRLARAKAE--------------ALVIGADTVVV-- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627   95 gLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQldtrvSEFYEETKVKFSELSEELLWEYVHSGEPMDKAG 174
Cdd:pfam02545  64 -LILGKPKDEEEARAMLKRLSGRTHEVYTGVALINPGGGTGG-----VSFVETTRVTFRPLSDEEIEAYVATGEPLDKAG 137

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 117553627  175 GYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKL 211
Cdd:pfam02545 138 AYGIQGLGAALVERIEGDYSNVVGLPLIELLRLLREL 174
Maf COG0424
7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily [Secondary ...
 13-201 1.07e-71

7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440193  Cd Length: 189  Bit Score: 229.16  E-value: 1.07e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  13 KRVVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKAsfATPYGYAMETAKQKALEVANRLyqkdlrAPDVVIGADTIVT 92
Cdd:COG0424    1 PKLILASASPRRRELLEQLGLPFEVVPPDIDETPLPG--ESPEELVLRLARAKAEAVAARL------PDALVLGADTVVV 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  93 VGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHcsskdhqLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDK 172
Cdd:COG0424   73 LDGRILGKPADAEEARAMLRRLSGRTHRVHTGVALID-------PGGRLWTRVVTTRVTFRPLSDAEIEAYLATGEPLDK 145

                        170       180
                 ....*....|....*....|....*....
gi 117553627 173 AGGYGIQALGGMLVESVHGDFLNVVGFPL 201
Cdd:COG0424  146 AGAYGIQGLGAALVERIEGSYSNVVGLPL 174
PRK00648 PRK00648
Maf-like protein; Reviewed
 13-211 3.46e-65

Maf-like protein; Reviewed


Pssm-ID: 234807  Cd Length: 191  Bit Score: 212.07  E-value: 3.46e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  13 KRVVLASASPRRQEILSNAGLRFEVVPSKFKEKlDKASFATPYGYAMETAKQKALEVANRLYQKDLrapdvVIGADTIVT 92
Cdd:PRK00648   3 YKIILASSSPRRKEILEGFRIPFEVVPSPFVEE-SYPYSLDPEEITLELARLKAEAVRSDLFPDEL-----IITADTIVW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  93 VGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHcsskdhqlDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDK 172
Cdd:PRK00648  77 YDGKVLGKPKDEEEAVEMLRTLSGKTHEVITGVCLLH--------NGKLLSGSETTQVTFRELSDEEIEYYIDTYKPLDK 148

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 117553627 173 AGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKL 211
Cdd:PRK00648 149 AGAYGIQEWGGLIVKKIEGSYYNVMGLPIQTLYEELKEL 187
Methyltransf_2 pfam00891
O-methyltransferase domain; This family includes a range of O-methyltransferases. These ...
 388-599 3.60e-62

O-methyltransferase domain; This family includes a range of O-methyltransferases. These enzymes utilize S-adenosyl methionine.


Pssm-ID: 395719 [Multi-domain]  Cd Length: 208  Bit Score: 204.95  E-value: 3.60e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  388 FTYLEFAIREGTNQHHRALGKKAedlfQDAYYQSPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALAR 467
Cdd:pfam00891   1 WRYLADAVREGRNQYNKAFGISL----FEAIYRDEEERLLFNRGLQEHWSLIGKDVLTAFDLSGFRSLVDVGGGTGALAQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  468 ELAREYPRMQVTVFDLPDIIELA-AHFQPPGPQAVQIHfaAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLSRVAESC 546
Cdd:pfam00891  77 AIVSLYPGCKGIVFDLPHVVEAApTHFSAGEEPRVTFH--GGDFFKDSLPEADAYILKRVLHDWSDEKCVKLLKRCYKAC 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 117553627  547 KPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGF 599
Cdd:pfam00891 155 PAGGKVILVESLLGADPSGPLHTQLYSLNMLAQTEGRERTEAEYSELLTGAGF 207
maf TIGR00172
MAF protein; This nonessential gene causes inhibition of septation when overexpressed. A ...
 13-208 2.11e-52

MAF protein; This nonessential gene causes inhibition of septation when overexpressed. A member of the family is found in the Archaeon Pyrococcus horikoshii and another in the round worm Caenorhabditis elegans. [Cellular processes, Cell division]


Pssm-ID: 129276  Cd Length: 183  Bit Score: 177.97  E-value: 2.11e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627   13 KRVVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLyqkdlraPD-VVIGADTIV 91
Cdd:TIGR00172   3 KELILASQSPRRKELLEELGISFEQIVSEFDEKSLKTT--SPRELVYRLAKEKAQAVAELL-------ADaLIIGADTVV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627   92 TVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVhcsSKDHQLDtrvseFYEETKVKFSELSEELLWEYVHSGEPMD 171
Cdd:TIGR00172  74 ILDGEIYGKPKDKEEAAEFLRKLSGQEHEVYTAVALI---DSVHLLT-----FLDVTKVHFRALDPEEIEKYVESGEPLE 145

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 117553627  172 KAGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQL 208
Cdd:TIGR00172 146 KAGAFGIEGFGAPLIKKIDGDYSNVVGLPLEKLLGAL 182
dimerization2 pfam16864
dimerization domain; This domain, found in methyltransferases, functions as a dimerization ...
 288-371 2.15e-32

dimerization domain; This domain, found in methyltransferases, functions as a dimerization domain.


Pssm-ID: 465287  Cd Length: 87  Bit Score: 119.59  E-value: 2.15e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  288 LLELIEGFMLSKGLLTACKLKVFDLLKdEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQ----GYSNTETANV 363
Cdd:pfam16864   1 LLDLIDGFRASKVLFTACELGVFDLLA-EGPLSAEEVAARLGASVDGTERLLDACVALGLLEREKTdgkgLYSNTELAST 79


                  ....*...
gi 117553627  364 YLASDGEY 371
Cdd:pfam16864  80 YLVSSSPK 87
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 440-572 2.90e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 48.37  E-value: 2.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627 440 ACQVATAFNLSRFSSACDVGgC-TGALARELAREYpRMQVTVFDL-PDIIELAAHFQPPGPQAvQIHFAAGDFFRD---P 514
Cdd:COG0500   15 AALLALLERLPKGGRVLDLG-CgTGRNLLALAARF-GGRVIGIDLsPEAIALARARAAKAGLG-NVEFLVADLAELdplP 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 117553627 515 LPSAELYVLCRILHDWPDDKVHKLLSRVAESCKPGAGLLLVETLLDEEKRVAQRALMQ 572
Cdd:COG0500   92 AESFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLA 149
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 457-559 1.49e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.57  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627 457 DVGGCTGALARELAREYPRmQVTVFDL-PDIIELAAHFQPpGPQAVQIHFAAGDFFRDPLPSAELY--VLCRILHDWPDD 533
Cdd:cd02440    4 DLGCGTGALALALASGPGA-RVTGVDIsPVALELARKAAA-ALLADNVEVLKGDAEELPPEADESFdvIISDPPLHHLVE 81

                         90       100
                 ....*....|....*....|....*.
gi 117553627 534 KVHKLLSRVAESCKPGaGLLLVETLL 559
Cdd:cd02440   82 DLARFLEEARRLLKPG-GVLVLTLVL 106
 
Name Accession Description Interval E-value
Maf cd00555
Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in ...
 15-208 2.92e-81

Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or nucleic acid-binding protein with structural similarity to the hypoxanthine/xanthine NTP pyrophosphatase Ham1 from Methanococcus jannaschii, RNase H from Escherichia coli, and some other nucleotide or RNA-binding proteins.


Pssm-ID: 238310  Cd Length: 180  Bit Score: 253.55  E-value: 2.92e-81
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  15 VVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLyqkdlRAPDVVIGADTIVTVG 94
Cdd:cd00555    1 LILASASPRRRELLEQLGIPFEVVPSDIDETPIKGE--SPEDYVLRLAEAKAEAVAARL-----PPDALVIGADTVVVLD 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  95 GLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCsskdhqlDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKAG 174
Cdd:cd00555   74 GRILGKPKDREEAREMLKRLSGRTHEVYTGVALIDP-------GGKLVTDVESTKVRFRELSDEEIEAYVASGEPLDKAG 146

                        170       180       190
                 ....*....|....*....|....*....|....
gi 117553627 175 GYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQL 208
Cdd:cd00555  147 AYGIQGLGGALIERIEGDYSNVVGLPLPELLKLL 180
Maf pfam02545
Maf-like protein; Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and ...
 15-211 8.17e-73

Maf-like protein; Maf is a putative inhibitor of septum formation in eukaryotes, bacteria, and archaea.


Pssm-ID: 460586  Cd Length: 174  Bit Score: 231.52  E-value: 8.17e-73
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627   15 VVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASfATPYGYAMETAKQKALevanrlyqkdlrapDVVIGADTIVTvg 94
Cdd:pfam02545   1 LILASASPRRRELLEQLGIEFEVVPSDIDETPLKED-PAPEEYVLRLARAKAE--------------ALVIGADTVVV-- 63

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627   95 gLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQldtrvSEFYEETKVKFSELSEELLWEYVHSGEPMDKAG 174
Cdd:pfam02545  64 -LILGKPKDEEEARAMLKRLSGRTHEVYTGVALINPGGGTGG-----VSFVETTRVTFRPLSDEEIEAYVATGEPLDKAG 137

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 117553627  175 GYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKL 211
Cdd:pfam02545 138 AYGIQGLGAALVERIEGDYSNVVGLPLIELLRLLREL 174
Maf COG0424
7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily [Secondary ...
 13-201 1.07e-71

7-methyl-GTP pyrophosphatase and related NTP pyrophosphatases, Maf/HAM1 superfamily [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440193  Cd Length: 189  Bit Score: 229.16  E-value: 1.07e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  13 KRVVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKAsfATPYGYAMETAKQKALEVANRLyqkdlrAPDVVIGADTIVT 92
Cdd:COG0424    1 PKLILASASPRRRELLEQLGLPFEVVPPDIDETPLPG--ESPEELVLRLARAKAEAVAARL------PDALVLGADTVVV 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  93 VGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHcsskdhqLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDK 172
Cdd:COG0424   73 LDGRILGKPADAEEARAMLRRLSGRTHRVHTGVALID-------PGGRLWTRVVTTRVTFRPLSDAEIEAYLATGEPLDK 145

                        170       180
                 ....*....|....*....|....*....
gi 117553627 173 AGGYGIQALGGMLVESVHGDFLNVVGFPL 201
Cdd:COG0424  146 AGAYGIQGLGAALVERIEGSYSNVVGLPL 174
PRK00648 PRK00648
Maf-like protein; Reviewed
 13-211 3.46e-65

Maf-like protein; Reviewed


Pssm-ID: 234807  Cd Length: 191  Bit Score: 212.07  E-value: 3.46e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  13 KRVVLASASPRRQEILSNAGLRFEVVPSKFKEKlDKASFATPYGYAMETAKQKALEVANRLYQKDLrapdvVIGADTIVT 92
Cdd:PRK00648   3 YKIILASSSPRRKEILEGFRIPFEVVPSPFVEE-SYPYSLDPEEITLELARLKAEAVRSDLFPDEL-----IITADTIVW 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  93 VGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHcsskdhqlDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDK 172
Cdd:PRK00648  77 YDGKVLGKPKDEEEAVEMLRTLSGKTHEVITGVCLLH--------NGKLLSGSETTQVTFRELSDEEIEYYIDTYKPLDK 148

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 117553627 173 AGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKL 211
Cdd:PRK00648 149 AGAYGIQEWGGLIVKKIEGSYYNVMGLPIQTLYEELKEL 187
Methyltransf_2 pfam00891
O-methyltransferase domain; This family includes a range of O-methyltransferases. These ...
 388-599 3.60e-62

O-methyltransferase domain; This family includes a range of O-methyltransferases. These enzymes utilize S-adenosyl methionine.


Pssm-ID: 395719 [Multi-domain]  Cd Length: 208  Bit Score: 204.95  E-value: 3.60e-62
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  388 FTYLEFAIREGTNQHHRALGKKAedlfQDAYYQSPETRLRFMRAMHGMTKLTACQVATAFNLSRFSSACDVGGCTGALAR 467
Cdd:pfam00891   1 WRYLADAVREGRNQYNKAFGISL----FEAIYRDEEERLLFNRGLQEHWSLIGKDVLTAFDLSGFRSLVDVGGGTGALAQ 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  468 ELAREYPRMQVTVFDLPDIIELA-AHFQPPGPQAVQIHfaAGDFFRDPLPSAELYVLCRILHDWPDDKVHKLLSRVAESC 546
Cdd:pfam00891  77 AIVSLYPGCKGIVFDLPHVVEAApTHFSAGEEPRVTFH--GGDFFKDSLPEADAYILKRVLHDWSDEKCVKLLKRCYKAC 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 117553627  547 KPGAGLLLVETLLDEEKRVAQRALMQSLNMLVQTEGKERSLGEYQCLLELHGF 599
Cdd:pfam00891 155 PAGGKVILVESLLGADPSGPLHTQLYSLNMLAQTEGRERTEAEYSELLTGAGF 207
PRK00078 PRK00078
Maf-like protein; Reviewed
 13-212 4.62e-61

Maf-like protein; Reviewed


Pssm-ID: 234618  Cd Length: 192  Bit Score: 201.11  E-value: 4.62e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  13 KRVVLASASPRRQEILSNAGLRFEVVPSKFKEklDKASFATPYG-YAMETAKQKALEVANRLYQKDlrapDVVIGADTIV 91
Cdd:PRK00078   1 MKIILASASERRQELLKRILEDFQVIVSDFDE--SSVPFKGNIEsYVMNLAEGKARSVSKKLDQES----SIVIGCDTIV 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  92 TVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVhcsskDHQLDTRVSEFyEETKVKFSELSEELLWEYVHSGEPMD 171
Cdd:PRK00078  75 AFNGKVLGKPKDEEDAFEMLKALSGNEHEVYSGIAIL-----DTKSNKIIKDF-VCTEVKFSKLTDRQIRKYINTGEPMD 148

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 117553627 172 KAGGYGIQALGGMLVESVHGDFLNVVGFPLNhfckqlvKLY 212
Cdd:PRK00078 149 KAGAYGIQGKGGVFVEEINGCYYNVVGLPLN-------KLY 182
maf TIGR00172
MAF protein; This nonessential gene causes inhibition of septation when overexpressed. A ...
 13-208 2.11e-52

MAF protein; This nonessential gene causes inhibition of septation when overexpressed. A member of the family is found in the Archaeon Pyrococcus horikoshii and another in the round worm Caenorhabditis elegans. [Cellular processes, Cell division]


Pssm-ID: 129276  Cd Length: 183  Bit Score: 177.97  E-value: 2.11e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627   13 KRVVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLyqkdlraPD-VVIGADTIV 91
Cdd:TIGR00172   3 KELILASQSPRRKELLEELGISFEQIVSEFDEKSLKTT--SPRELVYRLAKEKAQAVAELL-------ADaLIIGADTVV 73

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627   92 TVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVhcsSKDHQLDtrvseFYEETKVKFSELSEELLWEYVHSGEPMD 171
Cdd:TIGR00172  74 ILDGEIYGKPKDKEEAAEFLRKLSGQEHEVYTAVALI---DSVHLLT-----FLDVTKVHFRALDPEEIEKYVESGEPLE 145

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 117553627  172 KAGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQL 208
Cdd:TIGR00172 146 KAGAFGIEGFGAPLIKKIDGDYSNVVGLPLEKLLGAL 182
PRK14363 PRK14363
Maf-like protein; Provisional
 14-201 5.71e-45

Maf-like protein; Provisional


Pssm-ID: 184647  Cd Length: 204  Bit Score: 158.52  E-value: 5.71e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  14 RVVLASASPRRQEILSNAGLRFEVVPSKFKEKLdkasfatpYGYAMETAKQKALEVANRLYQKDLRAPDVVIGADTIVTV 93
Cdd:PRK14363   2 RIILASSSPRRRQLMELLGIEFEVEKPDVEEEF--------LESPEETVRELSLRKAEWVFKKRKEEEILVIGSDTVVVL 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  94 GGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDhqldtrvsEFYEETKVKFSELSEELLWEYVHSGEPMDKA 173
Cdd:PRK14363  74 DGNILGKPESLEEAKGMLKKLSGRWHVVYTGVAFVSSETKD--------VIVSSTKVRFRELPESVIDYYVEKYRPLDKA 145

                        170       180
                 ....*....|....*....|....*...
gi 117553627 174 GGYGIQALGGMLVESVHGDFLNVVGFPL 201
Cdd:PRK14363 146 GAYGIQDFAAVFVEKIEGDFFTVVGFPL 173
PRK14368 PRK14368
Maf-like protein; Provisional
 14-201 2.55e-44

Maf-like protein; Provisional


Pssm-ID: 237693  Cd Length: 193  Bit Score: 156.48  E-value: 2.55e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  14 RVVLASASPRRQEILSNAGLRFEVVPSKFKEKLdkASFATPYGYAMETAKQKALEVANRlyqkdlRAPDVVIGADTIVTV 93
Cdd:PRK14368   6 PIVLASASPRRSELLASAGIEFDVVPADIPEEP--LPGEEPVDHVLRLAREKARAAAAL------AEGRFFIGADTIVVC 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  94 GGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVhcsskDHQLDTRVSEFYEeTKVKFSELSEELLWEYVHSGEPMDKA 173
Cdd:PRK14368  78 DGEIMGKPKDEADAVRMLKKLSGVPHEVITGFAVY-----DRERDGCVTKAVR-TKVFFKPLRDEEIRDYIATGCPMDKA 151

                        170       180
                 ....*....|....*....|....*...
gi 117553627 174 GGYGIQALGGMLVESVHGDFLNVVGFPL 201
Cdd:PRK14368 152 GAYAIQGGAAHMVRKIDGSYTNVVGLPL 179
PRK14361 PRK14361
Maf-like protein; Provisional
 15-201 3.53e-42

Maf-like protein; Provisional


Pssm-ID: 172837  Cd Length: 187  Bit Score: 150.47  E-value: 3.53e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  15 VVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASfatPYGYAMETAKQKALEVAnRLYqkdlraPD-VVIGADTIVTV 93
Cdd:PRK14361   1 VILASGSPRRRELLENLGVPFQVVVSGEAEDSTETD---PARLAAELALLKARAVA-RLH------PDaVVIAADTVVAL 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  94 GGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLdtrvsefyEETKVKFSELSEELLWEYVHSGEPMDKA 173
Cdd:PRK14361  71 GGVLLAKPADEAENEAFLRVLSGRTHQVYTGVAVLSRGTEQVGV--------ERTDVTFRALTAAEISFYARSGEGLDKA 142

                        170       180
                 ....*....|....*....|....*...
gi 117553627 174 GGYGIQALGGMLVESVHGDFLNVVGFPL 201
Cdd:PRK14361 143 GGYGIQGVGMALVSRVEGDYSNVVGFPL 170
PRK14365 PRK14365
Maf-like protein; Provisional
 13-211 1.23e-40

Maf-like protein; Provisional


Pssm-ID: 237690  Cd Length: 197  Bit Score: 146.50  E-value: 1.23e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  13 KRVVLASASPRRQEILSN-AGLRFEVVPSKFKE----KLDKASFAtpygyaMETAKQKALEVAnrlyqkdLRAPD-VVIG 86
Cdd:PRK14365   2 RRIILASASPRRKELLKQlIGDNFLVYPSSYEEppqpGLDPEELL------LKHSLEKARDVA-------KHFDSgIIIS 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  87 ADTIVTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVhcsskDHQLDTRVSEfYEETKVKFSELSEELLWEYVHS 166
Cdd:PRK14365  69 ADTSVFCNGEVLGKPASPENAEEMLEKLSGRKFLVITGLTVL-----DLDSGKEISE-IESTDVWMTELSREQILAYVRT 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 117553627 167 GEPMDKAGGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKL 211
Cdd:PRK14365 143 GEPLDKAGAFAIQGKGAVLVEKIEGDFFNVVGLPLFRLGKILEKL 187
PRK14362 PRK14362
Maf-like protein; Provisional
 14-210 1.37e-39

Maf-like protein; Provisional


Pssm-ID: 172838  Cd Length: 207  Bit Score: 144.23  E-value: 1.37e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  14 RVVLASASPRRQEILSNAGLRFEVVPSKFKEKlDKASFATPYGYAMETAKQKALEVANRlyqkdlRAPDVVIGADTIVTV 93
Cdd:PRK14362  13 PVVLASGSPRRREFLEQMGLPFEVILPGAAEP-SPIEGEQPEAYARRAAEAKARAVAAD------HAGRLVIAADTVVAL 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  94 GGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVhcsskdhQLDTRVSEFYEETKVKFSELSEELLWEYVHSGEPMDKA 173
Cdd:PRK14362  86 DGMILGKPADRADALSMLRRLAGRTHEVVSACCVV-------LPDGGREVFHAITRVTMWDWPEAALAAYVATGEPSDKA 158

                        170       180       190
                 ....*....|....*....|....*....|....*..
gi 117553627 174 GGYGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVK 210
Cdd:PRK14362 159 GAYGIQGIGAFLVRSIEGSWSNVVGLPVAELTALLLR 195
PRK14367 PRK14367
Maf-like protein; Provisional
 17-217 9.24e-34

Maf-like protein; Provisional


Pssm-ID: 237692  Cd Length: 202  Bit Score: 127.87  E-value: 9.24e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  17 LASASPRRQEILSNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLYQKDLRAPDV-VIGADTIVTVGG 95
Cdd:PRK14367   6 LGSNSPRRMEILTQLGYRVVKLPAGIDETVKAGE--TPARYVQRMAEEKNRTALTLFCETNGTMPDFpLITADTCVVSDG 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  96 LILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLDTrvsefyeeTKVKFSELSEELLWEYVHSGEPMDKAGG 175
Cdd:PRK14367  84 IILGKPRSQAEAIEFLNRLSGKQHTVLTAVCIHYRGKTSSRVQT--------NRVVFKPLSSEEISAYVQSGEPMDKAGA 155

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|...
gi 117553627 176 YGIQALGGMLVESVHGDFLNVVGFPLNHFCKQLVKL-YYPPRP 217
Cdd:PRK14367 156 YAVQGIGGIFIQSIEGSFSGIMGLPVYETVSMLQDLgYRSPLS 198
Maf_Ham1 cd00985
Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum ...
 15-153 1.11e-33

Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard nucleotides, such as hypoxanthine/xanthine NTP, but not standard nucleotides.


Pssm-ID: 238485  Cd Length: 131  Bit Score: 124.92  E-value: 1.11e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  15 VVLASASPRRQEILSNAG-LRFEVVPSKFKEKLDKASfatPYGYAMETAKQKALEVANRLyqkdlrAPDVVIGADTIVTV 93
Cdd:cd00985    1 LILASGSPRRLEELKQIGgIEFEVLPSDIDETGLKGE---PEDTVEELALLKARAVAERL------PDAPVIADDTGLVV 71

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  94 GGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHcsskdhqLDTRVSEFYEETKVKFS 153
Cdd:cd00985   72 DGRPGGKPARFAEALEMLRGLSGRTAEFVTAVALVD-------PDGKIITFEGETEGKIA 124
PRK14364 PRK14364
Maf-like protein; Provisional
 17-210 5.44e-33

Maf-like protein; Provisional


Pssm-ID: 184648  Cd Length: 181  Bit Score: 124.73  E-value: 5.44e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  17 LASASPRRQEILSNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKALEVANRLyqkdlraPD-VVIGADTIVTVGG 95
Cdd:PRK14364   1 LASSSPRRRELLQQLGLNFEIYSPDIDESVHEGE--LVHQYVERLAREKAQAVLNIF-------PDsVIIAADTSLGLDG 71

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  96 LILEKPVDKQDAYRMLSRLSGREHSVFTGVAIvhcSSKDHQLDTRVsefyeETKVKFSELSEELLWEYVHSGEPMDKAGG 175
Cdd:PRK14364  72 QIIGKPDSKQHAFDIWKQLSGRWHDVFSGICI---ATQQQILSQVV-----QTQVEFASLTTQDMEDYWATGEPVGKAGA 143

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 117553627 176 YGIQALGGMLVESVHGDFLNVVGFPLNHFCkQLVK 210
Cdd:PRK14364 144 YAIQGIASQYIPKIQGSYSNVVGLPLYEFS-QLFK 177
dimerization2 pfam16864
dimerization domain; This domain, found in methyltransferases, functions as a dimerization ...
 288-371 2.15e-32

dimerization domain; This domain, found in methyltransferases, functions as a dimerization domain.


Pssm-ID: 465287  Cd Length: 87  Bit Score: 119.59  E-value: 2.15e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  288 LLELIEGFMLSKGLLTACKLKVFDLLKdEAPQKAADIASKVDASACGMERLLDICAAMGLLEKTEQ----GYSNTETANV 363
Cdd:pfam16864   1 LLDLIDGFRASKVLFTACELGVFDLLA-EGPLSAEEVAARLGASVDGTERLLDACVALGLLEREKTdgkgLYSNTELAST 79


                  ....*...
gi 117553627  364 YLASDGEY 371
Cdd:pfam16864  80 YLVSSSPK 87
PRK01441 PRK01441
Maf-like protein; Reviewed
 10-201 2.16e-29

Maf-like protein; Reviewed


Pssm-ID: 167232  Cd Length: 207  Bit Score: 115.58  E-value: 2.16e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  10 LLHKRVVLASASPRRQEILSNAGLRFE-VVPSKFKEKLDKASFatPYGYAMETAKQKALEVANRLYQKDLRAPDVVIGAD 88
Cdd:PRK01441   2 AGRPKLVLASGSPRRVELLNQAGIEPDrLMPADIDETPKRAEH--PRSLARRLSREKAEAALEALQGDDDWRGAYILAAD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  89 TIVTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVhcsSKDHQLDTRVSEfyeeTKVKFSELSEELLWEYVHSGE 168
Cdd:PRK01441  80 TVVAVGRRILPKAELVDEASQCLRLLSGRNHRVYTGVCLV---TPDGKLRQKLVE----TRVRFKRLSREDIEAYLASGE 152

                        170       180       190
                 ....*....|....*....|....*....|...
gi 117553627 169 PMDKAGGYGIQALGGMLVESVHGDFLNVVGFPL 201
Cdd:PRK01441 153 WRGKAGGYAIQGIAGSFVVKLVGSYTNVVGLPL 185
PRK04694 PRK04694
Maf-like protein; Reviewed
 17-203 2.17e-27

Maf-like protein; Reviewed


Pssm-ID: 179873  Cd Length: 190  Bit Score: 109.28  E-value: 2.17e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  17 LASASPRRQEILSNAGLRFEVVPSKFKEKldKASFATPYGYAMETAKQKALEVANRLYQKDlrAPDVVIGADTIVTVGGL 96
Cdd:PRK04694   4 LASRSPRRRELLQRLDVPFQTLQLDVPEV--RAADESPDHYVQRVALEKAHAGLALVQAAD--ADAIVLGSDTEVVLGER 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  97 ILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVhCSSKDHQLDTRVSEfyeetkVKFSELSEELLWEYVHSGEPMDKAGGY 176
Cdd:PRK04694  80 VFGKPVDVDDAIAMLRALSGRTHQVLTAVVLV-CAQRAPAQALVVSE------VTFDLLDDAQIAAYAASGEPMGKAGAY 152

                        170       180
                 ....*....|....*....|....*..
gi 117553627 177 GIQALGGMLVESVHGDFLNVVGFPLNH 203
Cdd:PRK04694 153 AIQGRAERFIRHLSGSYSGVMGLPLYQ 179
PRK14366 PRK14366
Maf-like protein; Provisional
 15-201 3.64e-26

Maf-like protein; Provisional


Pssm-ID: 237691  Cd Length: 195  Bit Score: 106.04  E-value: 3.64e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  15 VVLASASPRRQEILSNAGLR-FEVVPSKFKEKLDKASFatPYGYAMETAKQKALEVANrlyqkdLRAPDVVIGADTIVTV 93
Cdd:PRK14366   7 LILASSSKQRLALLEQIGVVpGEIVSPDIDESPLKKEL--PKDYSIRMAKEKAEKVQS------LRPDKFVLGADTVVCC 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  94 GGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHqLDTRVsefyeeTKVKFSELSEELLWEYVHSGEPMDKA 173
Cdd:PRK14366  79 GRRILLKAETEEQAEEYLELLSGRRHRVYTSVCLYTPGGKLH-IRSVV------TVVKFKRLSKQEIKYYIASGEWKGKA 151

                        170       180
                 ....*....|....*....|....*...
gi 117553627 174 GGYGIQALGGMLVESVHGDFLNVVGFPL 201
Cdd:PRK14366 152 GGCNIQGLAGKFVLSINGSYSSIIGLPL 179
PRK04056 PRK04056
septum formation inhibitor Maf;
15-199 1.09e-19

septum formation inhibitor Maf;


Pssm-ID: 179732  Cd Length: 180  Bit Score: 86.94  E-value: 1.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  15 VVLASASPRRQEILSNAGLRFEVVPSKFKEKLDKASfaTPYGYAMETAKQKaLEVANRLYQKDlrapDVVIGADTIVTVG 94
Cdd:PRK04056   2 IILASSSSTRANLLKEAGIEFEQKSLDFDEESIKKT--SPKEFVYLAVKGK-LEQFLKKYGNE----CNLLVADSVVSCG 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  95 GLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVhcsSKDHQLDtRVSefyeETKVKFSELSEELLWEYVHSGEPMDKAg 174
Cdd:PRK04056  75 NKILRKAKDKEEAREMLKLQSGNEISVLTCMILK---SPEKEWL-DLS----VTTYRFKKFDEDDLEKYLESGLWQGKA- 145

                        170       180
                 ....*....|....*....|....*.
gi 117553627 175 gygiqalGGMLVESVHGDFL-NVVGF 199
Cdd:PRK04056 146 -------GACMVEGFHKKYIkSVSGN 164
PRK02478 PRK02478
Maf-like protein; Reviewed
 15-201 1.88e-19

Maf-like protein; Reviewed


Pssm-ID: 167380  Cd Length: 199  Bit Score: 86.71  E-value: 1.88e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  15 VVLASASPRRQEILSNAGLRFEVVPSKFKEK-----LDKASfATPYGYAMETAKQKALEVANRLyqkdlraPD-VVIGAD 88
Cdd:PRK02478   5 LILASKSPFRRALLENAGLEFSAAAADIDERaveapLEESG-ATPEDVALVLAEAKAIDVSERF-------PGaLVIGCD 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  89 TIVTVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHcsskdhqldtrvsefyeetkvkfselSEELLWEYV---- 164
Cdd:PRK02478  77 QTMSLGDEVFHKPKDMEEARRHLQKLSGKTHQLNSAVVLVR--------------------------DGKVLWRHVsiah 130

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 117553627 165 -------------HSGEPMDKA----GGYGIQALGGMLVESVHGDFLNVVGFPL 201
Cdd:PRK02478 131 mtmrdldagfigrHLARVGEKAlssvGAYQLEGEGIQLFEKIEGDYFTILGLPL 184
PRK02141 PRK02141
Maf-like protein; Reviewed
 14-215 1.43e-18

Maf-like protein; Reviewed


Pssm-ID: 235009  Cd Length: 207  Bit Score: 84.42  E-value: 1.43e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  14 RVVLASASPRRQEILSNAGLRFEVVPSKFKEKldKASFATPYGYAMETAKQKALEVANRlyqkdLRAPD--VVIGADTIV 91
Cdd:PRK02141  10 RLILASSSRYRRELLERLRLPFDVVSPDIDET--PLAGETPAATALRLAAAKARAVAAT-----IDAPPgaLVIGSDQVA 82

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  92 TVGGLILEKPVDKQDAYRMLSRLSGREHSVFTGVAIVHCSSKDHQLDTRVsefyeeTKVKFSELSEELLWEYVHSGEPMD 171
Cdd:PRK02141  83 TFDGLQIGKPGTHERALAQLQAMRGRTVEFHSALCLYDSRTGETQSEDVV------TRVRFRTLTDAELDAYLRAETPYD 156

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 117553627 172 KAGGYGIQALGGMLVESVHG-DFLNVVGFPLNHFCKQLVKLYYPP 215
Cdd:PRK02141 157 VAGSAKSEGLGIALLDAIDSdDPTALVGLPLIALTRMLRAAGYPL 201
Methyltransf_25 pfam13649
Methyltransferase domain; This family appears to be a methyltransferase domain.
 457-549 1.91e-08

Methyltransferase domain; This family appears to be a methyltransferase domain.


Pssm-ID: 463945 [Multi-domain]  Cd Length: 96  Bit Score: 52.18  E-value: 1.91e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  457 DVGGCTGALARELAREYPRmQVTVFDL-PDIIELA-AHFQPPGPQavqIHFAAGDFFRDPLPSAEL-YVLCR-ILHDWPD 532
Cdd:pfam13649   3 DLGCGTGRLTLALARRGGA-RVTGVDLsPEMLERArERAAEAGLN---VEFVQGDAEDLPFPDGSFdLVVSSgVLHHLPD 78

                          90
                  ....*....|....*..
gi 117553627  533 DKVHKLLSRVAESCKPG 549
Cdd:pfam13649  79 PDLEAALREIARVLKPG 95
SmtA COG0500
SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, ...
 440-572 2.90e-06

SAM-dependent methyltransferase [Secondary metabolites biosynthesis, transport and catabolism, General function prediction only];


Pssm-ID: 440266 [Multi-domain]  Cd Length: 199  Bit Score: 48.37  E-value: 2.90e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627 440 ACQVATAFNLSRFSSACDVGgC-TGALARELAREYpRMQVTVFDL-PDIIELAAHFQPPGPQAvQIHFAAGDFFRD---P 514
Cdd:COG0500   15 AALLALLERLPKGGRVLDLG-CgTGRNLLALAARF-GGRVIGIDLsPEAIALARARAAKAGLG-NVEFLVADLAELdplP 91

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 117553627 515 LPSAELYVLCRILHDWPDDKVHKLLSRVAESCKPGAGLLLVETLLDEEKRVAQRALMQ 572
Cdd:COG0500   92 AESFDLVVAFGVLHHLPPEEREALLRELARALKPGGVLLLSASDAAAALSLARLLLLA 149
UbiE COG2226
Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; ...
 442-568 3.99e-06

Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG [Coenzyme transport and metabolism]; Ubiquinone/menaquinone biosynthesis C-methylase UbiE/MenG is part of the Pathway/BioSystem: Biotin biosynthesis


Pssm-ID: 441828 [Multi-domain]  Cd Length: 143  Bit Score: 46.91  E-value: 3.99e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627 442 QVATAFNLSRFSSACDVGGCTGALARELAREYPRmqVTVFDL-PDIIELAAHFQPpgPQAVQIHFAAGDFFRDPLPSAEL 520
Cdd:COG2226   13 ALLAALGLRPGARVLDLGCGTGRLALALAERGAR--VTGVDIsPEMLELARERAA--EAGLNVEFVVGDAEDLPFPDGSF 88

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 117553627 521 -YVLCR-ILHDWPDdkVHKLLSRVAESCKPGAGLLLVETLLDEEKRVAQR 568
Cdd:COG2226   89 dLVISSfVLHHLPD--PERALAEIARVLKPGGRLVVVDFSPPDLAELEEL 136
Methyltransf_12 pfam08242
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 457-552 4.79e-06

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 400515 [Multi-domain]  Cd Length: 98  Bit Score: 45.44  E-value: 4.79e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  457 DVGGCTGALARELAREYPRMQVTVFDL-PDIIELAAHF--QPPGPQAVQIHFAAGDFFRDPLPSAELYVLCRILHDWPDd 533
Cdd:pfam08242   2 EIGCGTGTLLRALLEALPGLEYTGLDIsPAALEAARERlaALGLLNAVRVELFQLDLGELDPGSFDVVVASNVLHHLAD- 80

                          90
                  ....*....|....*....
gi 117553627  534 kVHKLLSRVAESCKPGAGL 552
Cdd:pfam08242  81 -PRAVLRNIRRLLKPGGVL 98
UbiG COG2227
2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and ...
 453-557 7.37e-05

2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase [Coenzyme transport and metabolism]; 2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1,4-benzoquinol methylase is part of the Pathway/BioSystem: Ubiquinone biosynthesis


Pssm-ID: 441829 [Multi-domain]  Cd Length: 126  Bit Score: 42.70  E-value: 7.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627 453 SSACDVGGCTGALARELAREypRMQVTVFDL-PDIIELAAHFQPpgpqAVQIHFAAGDFFRDPLP--SAELYVLCRILHD 529
Cdd:COG2227   26 GRVLDVGCGTGRLALALARR--GADVTGVDIsPEALEIARERAA----ELNVDFVQGDLEDLPLEdgSFDLVICSEVLEH 99

                         90       100
                 ....*....|....*....|....*...
gi 117553627 530 WPDdkVHKLLSRVAESCKPGaGLLLVET 557
Cdd:COG2227  100 LPD--PAALLRELARLLKPG-GLLLLST 124
SpeE COG0421
Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];
458-514 2.58e-04

Spermidine synthase (polyamine aminopropyltransferase) [Amino acid transport and metabolism];


Pssm-ID: 440190 [Multi-domain]  Cd Length: 195  Bit Score: 42.51  E-value: 2.58e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 117553627 458 VGGCTGALARELAREYPRMQVTVFDL-PDIIELA-AHFQPPGPQA----VQIHFA-AGDFFRDP 514
Cdd:COG0421   44 IGGGDGGLARELLKHPPVERVDVVEIdPEVVELArEYFPLLAPAFddprLRVVIGdGRAFLREA 107
Methyltransf_11 pfam08241
Methyltransferase domain; Members of this family are SAM dependent methyltransferases.
 457-555 8.01e-04

Methyltransferase domain; Members of this family are SAM dependent methyltransferases.


Pssm-ID: 462406 [Multi-domain]  Cd Length: 94  Bit Score: 38.80  E-value: 8.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627  457 DVGGCTGALARELAREYPRmqVTVFDL-PDIIELAAHFQPPgpqaVQIHFAAGDFFRDPLP--SAELYVLCRILHDWPDd 533
Cdd:pfam08241   2 DVGCGTGLLTELLARLGAR--VTGVDIsPEMLELAREKAPR----EGLTFVVGDAEDLPFPdnSFDLVLSSEVLHHVED- 74

                          90       100
                  ....*....|....*....|..
gi 117553627  534 kVHKLLSRVAESCKPGaGLLLV 555
Cdd:pfam08241  75 -PERALREIARVLKPG-GILII 94
AdoMet_MTases cd02440
S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; ...
 457-559 1.49e-03

S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). There are at least five structurally distinct families of AdoMet-MTases, class I being the largest and most diverse. Within this class enzymes can be classified by different substrate specificities (small molecules, lipids, nucleic acids, etc.) and different target atoms for methylation (nitrogen, oxygen, carbon, sulfur, etc.).


Pssm-ID: 100107 [Multi-domain]  Cd Length: 107  Bit Score: 38.57  E-value: 1.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 117553627 457 DVGGCTGALARELAREYPRmQVTVFDL-PDIIELAAHFQPpGPQAVQIHFAAGDFFRDPLPSAELY--VLCRILHDWPDD 533
Cdd:cd02440    4 DLGCGTGALALALASGPGA-RVTGVDIsPVALELARKAAA-ALLADNVEVLKGDAEELPPEADESFdvIISDPPLHHLVE 81

                         90       100
                 ....*....|....*....|....*.
gi 117553627 534 KVHKLLSRVAESCKPGaGLLLVETLL 559
Cdd:cd02440   82 DLARFLEEARRLLKPG-GVLVLTLVL 106
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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