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Conserved domains on  [gi|190194412|ref|NP_004230|]
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thyroid receptor-interacting protein 11 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 394-1235 2.06e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.88  E-value: 2.06e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   394 LSDAENEIMR-LSSLNQDNSLAEDNLKLKMRIEvlEKEKSLLSQEKEELQMSLLKLN---NEYEVIKSTATRDIS-LDSE 468
Cdd:TIGR02168  191 LEDILNELERqLKSLERQAEKAERYKELKAELR--ELELALLVLRLEELREELEELQeelKEAEEELEELTAELQeLEEK 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   469 LHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMilikDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLED 548
Cdd:TIGR02168  269 LEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERL----ANLERQLEELEAQLEELESKLDELAEELAELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   549 DKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELM 628
Cdd:TIGR02168  345 KLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   629 QSLNQDSNSNFKDT---------LLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKL---VLACEDVRHQLE-- 694
Cdd:TIGR02168  425 ELLKKLEEAELKELqaeleeleeELEELQEELERLEEALEELREELEEAEQALDAAERELAQLqarLDSLERLQENLEgf 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   695 -----ECLAGNNQLSLEKNTIVETLKMEKG---EIEAELCWAKKRLL-EEANKYEKTIEELSNARNLNTSALQLEHEHLI 765
Cdd:TIGR02168  505 segvkALLKNQSGLSGILGVLSELISVDEGyeaAIEAALGGRLQAVVvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGT 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   766 KLnQKKDMEIAELKKNIEQMDTDHKETKDVLS-------------SSLEEQKQLTQLINKKEIFI----EKLKERSSKLQ 828
Cdd:TIGR02168  585 EI-QGNDREILKNIEGFLGVAKDLVKFDPKLRkalsyllggvlvvDDLDNALELAKKLRPGYRIVtldgDLVRPGGVITG 663

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   829 EELDKYSQAL-RKNEI--LRQTIEEKDRSLGSMKEENNhlqeelerlreeqsrtapvadpKTLDSVTELASEVSQLNTIK 905
Cdd:TIGR02168  664 GSAKTNSSILeRRREIeeLEEKIEELEEKIAELEKALA----------------------ELRKELEELEEELEQLRKEL 721

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   906 EHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDE---EIKSLQKTIEQIKTQLHEE 982
Cdd:TIGR02168  722 EELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEaeaEIEELEAQIEQLKEELKAL 801

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   983 RQDIqTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLvkgIKERELEIKLLNEKNISLTKQIDQLskdevgkltqiiq 1062
Cdd:TIGR02168  802 REAL-DELRAELTLLNEEAANLRERLESLERRIAATERR---LEDLEEQIEELSEDIESLAAEIEEL------------- 864

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1063 qkDLEIQALHARIssTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKK 1142
Cdd:TIGR02168  865 --EELIEELESEL--EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1143 LSTRFESSGQDMFRETIQNLSriirekdiEIDALSQKCQTLLAVLQTSStgNEAGGVNSN---QFEELLQERDKLKQQVK 1219
Cdd:TIGR02168  941 LQERLSEEYSLTLEEAEALEN--------KIEDDEEEARRRLKRLENKI--KELGPVNLAaieEYEELKERYDFLTAQKE 1010

                          890
                   ....*....|....*.
gi 190194412  1220 KMEEWKQQVMTTVQNM 1235
Cdd:TIGR02168 1011 DLTEAKETLEEAIEEI 1026
SMC_prok_B super family cl37069
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 908-1752 7.57e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


The actual alignment was detected with superfamily member TIGR02168:

Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.86  E-value: 7.57e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   908 LEEEIKHHQKII-----EDQNQSKMQLLQSLQEQKKEMDEFRyqhEQMNATHTQL------FLEKDEEIKSLQKTIEQIK 976
Cdd:TIGR02168  218 LKAELRELELALlvlrlEELREELEELQEELKEAEEELEELT---AELQELEEKLeelrleVSELEEEIEELQKELYALA 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   977 TQLHEERQDIQ-TDNSDIFQETKVQSLN--IENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDE 1053
Cdd:TIGR02168  295 NEISRLEQQKQiLRERLANLERQLEELEaqLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRL 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1054 VGKLTQIIQQKDLEIQALHARissTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMdiVAAKEAAL 1133
Cdd:TIGR02168  375 EELEEQLETLRSKVAQLELQI---ASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAE--LEELEEEL 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1134 IKLQDENKKLSTRFESSgqdmfRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDK 1213
Cdd:TIGR02168  450 EELQEELERLEEALEEL-----REELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGV 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1214 LKQQVKKMEEWKQQVmttvqnmqheSAQLQEELhqlqaQVLVDSDNNSKLQvdytgLIQSYEQNETKLKNF-------GQ 1286
Cdd:TIGR02168  525 LSELISVDEGYEAAI----------EAALGGRL-----QAVVVENLNAAKK-----AIAFLKQNELGRVTFlpldsikGT 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1287 ELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSAslLTPQSAECLRASksevlsesselLQQELEELRKSLQEKdATIRTL 1366
Cdd:TIGR02168  585 EIQGNDREILKNIEGFLGVAKDLVKFDPKLRKA--LSYLLGGVLVVD-----------DLDNALELAKKLRPG-YRIVTL 650

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1367 QENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTN 1446
Cdd:TIGR02168  651 DGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISA 730

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1447 LKERILILEMDIGKLkgenekivetyrgkETEYQALQETNMKfsmmLREKEFECHSMKEKALAFEQLLKEKEQGKTGELN 1526
Cdd:TIGR02168  731 LRKDLARLEAEVEQL--------------EERIAQLSKELTE----LEAEIEELEERLEEAEEELAEAEAEIEELEAQIE 792

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1527 QLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRnhllESEDSYTREALAAEDRE 1606
Cdd:TIGR02168  793 QLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELS----EDIESLAAEIEELEELI 868

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1607 AKLRKKVTVLEEKLvsssNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQE 1686
Cdd:TIGR02168  869 EELESELEALLNER----ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQER 944

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1687 EKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEAN----AALDSASRLTEQLDVKEEQIEELKR 1752
Cdd:TIGR02168  945 LSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGpvnlAAIEEYEELKERYDFLTAQKEDLTE 1014
YhaN super family cl34808
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
171-545 1.29e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


The actual alignment was detected with superfamily member COG4717:

Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.15  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  171 QQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRsQEIDDHQHEMSVLQNAHQQKLTEI 250
Cdd:COG4717   108 EAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELE-EELEELEAELAELQEELEELLEQL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  251 SRRHREELSDYEERIEELENLLQQggsgvIETDLSKIYEMQKTIQVlQIEKVESTKKMEQLEDKIKD------------- 317
Cdd:COG4717   187 SLATEEELQDLAEELEELQQRLAE-----LEEELEEAQEELEELEE-ELEQLENELEAAALEERLKEarlllliaaalla 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  318 --------------------------------INKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLecsklqpsav 365
Cdd:COG4717   261 llglggsllsliltiagvlflvlgllallfllLAREKASLGKEAEELQALPALEELEEEELEELLAALGL---------- 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  366 kqsDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSL-----AEDNLKLKMRIEVLEKEKSLLsQEKEE 440
Cdd:COG4717   331 ---PPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALlaeagVEDEEELRAALEQAEEYQELK-EELEE 406

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  441 LQMSLLKLNNEYEVIKSTATRDiSLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQ-EATKHMILIKDQLS 519
Cdd:COG4717   407 LEEQLEELLGELEELLEALDEE-ELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGElAELLQELEELKAEL 485

                         410       420
                  ....*....|....*....|....*.
gi 190194412  520 KQQNEGDSIISKLKQDLNDEKKRVHQ 545
Cdd:COG4717   486 RELAEEWAALKLALELLEEAREEYRE 511
GRAB super family cl11041
GRAB domain; The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type ...
 1774-1819 8.19e-04

GRAB domain; The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type proteins. This domain is related to the GRIP domain, but the conserved tyrosine residue found at position 4 in all GRIP domains is replaced by a leucine residue. The Arf small GTPase is localized to the cis-Golgi where it recruits proteins via their GRAB domain, as part of the transport of cargo from the endoplasmic reticulum to the plasma membrane.


The actual alignment was detected with superfamily member pfam10375:

Pssm-ID: 431241  Cd Length: 49  Bit Score: 39.13  E-value: 8.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 190194412  1774 SSEGKVDKVLMRNLFIGHFHTPK--NQRHEVLRLMGSILGVRREEMEQ 1819
Cdd:pfam10375    1 SSEDTVDRQLVTNLLLSFLSIPRgdTKKFEILQLIANLLEWDDEQREQ 48
bHLH_SF super family cl00081
basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators ...
 64-123 6.58e-03

basic Helix Loop Helix (bHLH) domain superfamily; bHLH proteins are transcriptional regulators that are found in organisms from yeast to humans. Members of the bHLH superfamily have two highly conserved and functionally distinct regions. The basic part is at the amino end of the bHLH that may bind DNA to a consensus hexanucleotide sequence known as the E box (CANNTG). Different families of bHLH proteins recognize different E-box consensus sequences. At the carboxyl-terminal end of the region is the HLH region that interacts with other proteins to form homo- and heterodimers. bHLH proteins function as a diverse set of regulatory factors because they recognize different DNA sequences and dimerize with different proteins. The bHLH proteins can be divided to cell-type specific and widely expressed proteins. The cell-type specific members of bHLH superfamily are involved in cell-fate determination and act in neurogenesis, cardiogenesis, myogenesis, and hematopoiesis.


The actual alignment was detected with superfamily member cd11400:

Pssm-ID: 469605 [Multi-domain]  Cd Length: 80  Bit Score: 37.53  E-value: 6.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   64 LRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLK 123
Cdd:cd11400    16 LKNSFEKLRDLVPELADNEKASKVVILKKATEYIKQLQQEEKKLEKEKDKLKARNEQLRK 75
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 394-1235 2.06e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.88  E-value: 2.06e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   394 LSDAENEIMR-LSSLNQDNSLAEDNLKLKMRIEvlEKEKSLLSQEKEELQMSLLKLN---NEYEVIKSTATRDIS-LDSE 468
Cdd:TIGR02168  191 LEDILNELERqLKSLERQAEKAERYKELKAELR--ELELALLVLRLEELREELEELQeelKEAEEELEELTAELQeLEEK 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   469 LHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMilikDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLED 548
Cdd:TIGR02168  269 LEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERL----ANLERQLEELEAQLEELESKLDELAEELAELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   549 DKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELM 628
Cdd:TIGR02168  345 KLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   629 QSLNQDSNSNFKDT---------LLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKL---VLACEDVRHQLE-- 694
Cdd:TIGR02168  425 ELLKKLEEAELKELqaeleeleeELEELQEELERLEEALEELREELEEAEQALDAAERELAQLqarLDSLERLQENLEgf 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   695 -----ECLAGNNQLSLEKNTIVETLKMEKG---EIEAELCWAKKRLL-EEANKYEKTIEELSNARNLNTSALQLEHEHLI 765
Cdd:TIGR02168  505 segvkALLKNQSGLSGILGVLSELISVDEGyeaAIEAALGGRLQAVVvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGT 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   766 KLnQKKDMEIAELKKNIEQMDTDHKETKDVLS-------------SSLEEQKQLTQLINKKEIFI----EKLKERSSKLQ 828
Cdd:TIGR02168  585 EI-QGNDREILKNIEGFLGVAKDLVKFDPKLRkalsyllggvlvvDDLDNALELAKKLRPGYRIVtldgDLVRPGGVITG 663

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   829 EELDKYSQAL-RKNEI--LRQTIEEKDRSLGSMKEENNhlqeelerlreeqsrtapvadpKTLDSVTELASEVSQLNTIK 905
Cdd:TIGR02168  664 GSAKTNSSILeRRREIeeLEEKIEELEEKIAELEKALA----------------------ELRKELEELEEELEQLRKEL 721

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   906 EHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDE---EIKSLQKTIEQIKTQLHEE 982
Cdd:TIGR02168  722 EELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEaeaEIEELEAQIEQLKEELKAL 801

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   983 RQDIqTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLvkgIKERELEIKLLNEKNISLTKQIDQLskdevgkltqiiq 1062
Cdd:TIGR02168  802 REAL-DELRAELTLLNEEAANLRERLESLERRIAATERR---LEDLEEQIEELSEDIESLAAEIEEL------------- 864

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1063 qkDLEIQALHARIssTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKK 1142
Cdd:TIGR02168  865 --EELIEELESEL--EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1143 LSTRFESSGQDMFRETIQNLSriirekdiEIDALSQKCQTLLAVLQTSStgNEAGGVNSN---QFEELLQERDKLKQQVK 1219
Cdd:TIGR02168  941 LQERLSEEYSLTLEEAEALEN--------KIEDDEEEARRRLKRLENKI--KELGPVNLAaieEYEELKERYDFLTAQKE 1010

                          890
                   ....*....|....*.
gi 190194412  1220 KMEEWKQQVMTTVQNM 1235
Cdd:TIGR02168 1011 DLTEAKETLEEAIEEI 1026
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 298-1147 2.19e-15

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 82.71  E-value: 2.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   298 QIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERI 377
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRD 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   378 LAQSasveevFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKlKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKS 457
Cdd:pfam02463  249 EQEE------IESSKQEIEKEEEKLAQVLKENKEEEKEKKLQ-EEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEK 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   458 TATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLN 537
Cdd:pfam02463  322 EKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKS 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   538 DEKKRV---HQLEDDKMDITKELDVQKEKL---IQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKE 611
Cdd:pfam02463  402 EEEKEAqllLELARQLEDLLKEEKKEELEIleeEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVK 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   612 HIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRH 691
Cdd:pfam02463  482 LQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVE 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   692 QLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK 771
Cdd:pfam02463  562 ERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESA 641

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   772 DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQaLRKNEILRQTIEEK 851
Cdd:pfam02463  642 KAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQ-REKEELKKLKLEAE 720

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   852 DRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQ 931
Cdd:pfam02463  721 ELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQE 800

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   932 -SLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEK 1010
Cdd:pfam02463  801 eELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELE 880

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1011 HDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQ-----QKDLEIQALHARISSTSHTQDVV 1085
Cdd:pfam02463  881 EQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKyeeepEELLLEEADEKEKEENNKEEEEE 960

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190194412  1086 YLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRF 1147
Cdd:pfam02463  961 RNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEF 1022
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 423-979 5.37e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 74.59  E-value: 5.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  423 RIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRdisLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDR 502
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEE---LRLELEELELELEEAQAEEYELLAELARLEQDIARLEE 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  503 QNQEATKHmiliKDQLSKQQNEgdsiiskLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLE 582
Cdd:COG1196   310 RRRELEER----LEELEEELAE-------LEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE 378

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  583 DKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDsnsnfkDTLLKEREAEVRNLKQNLSELE 662
Cdd:COG1196   379 EELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEAL------AELEEEEEEEEEALEEAAEEEA 452

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  663 QLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKT 742
Cdd:COG1196   453 ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGV 532

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  743 IEELSNArnLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKE 822
Cdd:COG1196   533 EAAYEAA--LEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLRE 610

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  823 RSSK-------LQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS--RTAPVADPKTLDSVTE 893
Cdd:COG1196   611 ADARyyvlgdtLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAalLEAEAELEELAERLAE 690

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  894 LASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE 973
Cdd:COG1196   691 EELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELE 770


                  ....*.
gi 190194412  974 QIKTQL 979
Cdd:COG1196   771 RLEREI 776
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 908-1752 7.57e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.86  E-value: 7.57e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   908 LEEEIKHHQKII-----EDQNQSKMQLLQSLQEQKKEMDEFRyqhEQMNATHTQL------FLEKDEEIKSLQKTIEQIK 976
Cdd:TIGR02168  218 LKAELRELELALlvlrlEELREELEELQEELKEAEEELEELT---AELQELEEKLeelrleVSELEEEIEELQKELYALA 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   977 TQLHEERQDIQ-TDNSDIFQETKVQSLN--IENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDE 1053
Cdd:TIGR02168  295 NEISRLEQQKQiLRERLANLERQLEELEaqLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRL 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1054 VGKLTQIIQQKDLEIQALHARissTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMdiVAAKEAAL 1133
Cdd:TIGR02168  375 EELEEQLETLRSKVAQLELQI---ASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAE--LEELEEEL 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1134 IKLQDENKKLSTRFESSgqdmfRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDK 1213
Cdd:TIGR02168  450 EELQEELERLEEALEEL-----REELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGV 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1214 LKQQVKKMEEWKQQVmttvqnmqheSAQLQEELhqlqaQVLVDSDNNSKLQvdytgLIQSYEQNETKLKNF-------GQ 1286
Cdd:TIGR02168  525 LSELISVDEGYEAAI----------EAALGGRL-----QAVVVENLNAAKK-----AIAFLKQNELGRVTFlpldsikGT 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1287 ELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSAslLTPQSAECLRASksevlsesselLQQELEELRKSLQEKdATIRTL 1366
Cdd:TIGR02168  585 EIQGNDREILKNIEGFLGVAKDLVKFDPKLRKA--LSYLLGGVLVVD-----------DLDNALELAKKLRPG-YRIVTL 650

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1367 QENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTN 1446
Cdd:TIGR02168  651 DGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISA 730

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1447 LKERILILEMDIGKLkgenekivetyrgkETEYQALQETNMKfsmmLREKEFECHSMKEKALAFEQLLKEKEQGKTGELN 1526
Cdd:TIGR02168  731 LRKDLARLEAEVEQL--------------EERIAQLSKELTE----LEAEIEELEERLEEAEEELAEAEAEIEELEAQIE 792

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1527 QLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRnhllESEDSYTREALAAEDRE 1606
Cdd:TIGR02168  793 QLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELS----EDIESLAAEIEELEELI 868

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1607 AKLRKKVTVLEEKLvsssNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQE 1686
Cdd:TIGR02168  869 EELESELEALLNER----ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQER 944

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1687 EKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEAN----AALDSASRLTEQLDVKEEQIEELKR 1752
Cdd:TIGR02168  945 LSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGpvnlAAIEEYEELKERYDFLTAQKEDLTE 1014
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
213-830 1.92e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.77  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  213 KLQNIIKELKQNRSQEIDDHQHEMSV--LQNAHQQKLTEISRRHREELSDYEERIEELENLlqqggsgviETDLSKIYEM 290
Cdd:PRK03918  166 NLGEVIKEIKRRIERLEKFIKRTENIeeLIKEKEKELEEVLREINEISSELPELREELEKL---------EKEVKELEEL 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  291 QKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSsaendrdilrreqeqlnvEKRQIMEECENLKLECSKLQPSAVKQSDT 370
Cdd:PRK03918  237 KEEIEELEKELESLEGSKRKLEEKIRELEERIE------------------ELKKEIEELEEKVKELKELKEKAEEYIKL 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  371 MTEKERILAQSASVEEvfRLQQALSDAENEIMRLSSLNQDNSLAEdnlKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN 450
Cdd:PRK03918  299 SEFYEEYLDELREIEK--RLSRLEEEINGIEERIKELEEKEERLE---ELKKKLKELEKRLEELEERHELYEEAKAKKEE 373

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  451 EYEVIKSTATRDIS-LDSELHDL---RLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGd 526
Cdd:PRK03918  374 LERLKKRLTGLTPEkLEKELEELekaKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKE- 452

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  527 sIISKLKQDLNDEKKRVHQLEDDKMDITKELdVQKEKLIQSEVALNDLHltkqKLEDKVENLVDQLNKSQESNVSIQKEN 606
Cdd:PRK03918  453 -LLEEYTAELKRIEKELKEIEEKERKLRKEL-RELEKVLKKESELIKLK----ELAEQLKELEEKLKKYNLEELEKKAEE 526

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  607 LE-LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL-----EQLNENLKKVAfdvKMENE 680
Cdd:PRK03918  527 YEkLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgfesvEELEERLKELE---PFYNE 603

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  681 KLVLacEDVRHQLEECLagnNQLSLEKNTIVETLKmEKGEIEAELCWAKKRLLEEANKYEKtiEELSNARNLNTSalqLE 760
Cdd:PRK03918  604 YLEL--KDAEKELEREE---KELKKLEEELDKAFE-ELAETEKRLEELRKELEELEKKYSE--EEYEELREEYLE---LS 672

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190194412  761 HEHLIKLNQKKDME--IAELKKNIEQMdtdhKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEE 830
Cdd:PRK03918  673 RELAGLRAELEELEkrREEIKKTLEKL----KEELEEREKAKKELEKLEKALERVEELREKVKKYKALLKER 740
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1353-1681 1.68e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.67  E-value: 1.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1353 RKSLQEKDATIRTLQENNHRLSDSIAATSELERKEhEQTDSEIKQLKEKQDV----LQKLLKEKDLLIKAKSdQLLSSNE 1428
Cdd:pfam15921  478 RKVVEELTAKKMTLESSERTVSDLTASLQEKERAI-EATNAEITKLRSRVDLklqeLQHLKNEGDHLRNVQT-ECEALKL 555

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1429 NFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKE-----FECHSM 1503
Cdd:pfam15921  556 QMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEarvsdLELEKV 635

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1504 KEKALAFEQLLKEKEQGKtgELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMEntaLQNEVQRLRDKEFRSNQELER 1583
Cdd:pfam15921  636 KLVNAGSERLRAVKDIKQ--ERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEE---METTTNKLKMQLKSAQSELEQ 710

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1584 LRNHL--LESEDSYT-REALAAEDREAKLRKKVTVLEEKLVSSSNAMENAS---HQASVQVESLQEQLNVVSKQRDETAL 1657
Cdd:pfam15921  711 TRNTLksMEGSDGHAmKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANkekHFLKEEKNKLSQELSTVATEKNKMAG 790

                          330       340
                   ....*....|....*....|....
gi 190194412  1658 QLSVSQEQVKQYALSLANLQMVLE 1681
Cdd:pfam15921  791 ELEVLRSQERRLKEKVANMEVALD 814
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1503-1765 1.43e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.40  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1503 MKEKALAFEQLLKEKEQgKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
Cdd:COG1196   248 LEELEAELEELEAELAE-LEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELA 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1583 RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVS 1662
Cdd:COG1196   327 ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELE 406

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1663 QEQVKQYALSLANLQMVLEHFQQEEKAmySAELEKQKQLIAEWKKNAENLEGKVISLQECLDEanaALDSASRLTEQLDV 1742
Cdd:COG1196   407 EAEEALLERLERLEEELEELEEALAEL--EEEEEEEEEALEEAAEEEAELEEEEEALLELLAE---LLEEAALLEAALAE 481

                         250       260
                  ....*....|....*....|...
gi 190194412 1743 KEEQIEELKRQNELRQEMLDDVQ 1765
Cdd:COG1196   482 LLEELAEAAARLLLLLEAEADYE 504
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1363-1771 1.14e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.45  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1363 IRTLQENNHRLSDSIAATSELERKEHEQTDS---EIKQLKEKQDVLQKLLKEKDLLIKAKSDqLLSSNENFTNKVNENEL 1439
Cdd:PRK03918  171 IKEIKRRIERLEKFIKRTENIEELIKEKEKEleeVLREINEISSELPELREELEKLEKEVKE-LEELKEEIEELEKELES 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1440 LRQAVTNLKERILILEMDIGKLKG------ENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQL 1513
Cdd:PRK03918  250 LEGSKRKLEEKIRELEERIEELKKeieeleEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEER 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1514 LKEKEQgKTGELNQLLNAVKSMQEKTVVFQqERDQVMLALKQKQMENTALQNEVQRLR-DKEFRSNQELERLRNHLLESE 1592
Cdd:PRK03918  330 IKELEE-KEERLEELKKKLKELEKRLEELE-ERHELYEEAKAKKEELERLKKRLTGLTpEKLEKELEELEKAKEEIEEEI 407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1593 DSYTREALAAEDREAKLRKKVTVLEE-KLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYAL 1671
Cdd:PRK03918  408 SKITARIGELKKEIKELKKAIEELKKaKGKCPVCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEK 487

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1672 SLANLQMV---------LEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDV 1742
Cdd:PRK03918  488 VLKKESELiklkelaeqLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDE 567

                         410       420       430
                  ....*....|....*....|....*....|
gi 190194412 1743 KEEQIEELKRQ-NELRQEMLDDVQKKLMSL 1771
Cdd:PRK03918  568 LEEELAELLKElEELGFESVEELEERLKEL 597
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
171-545 1.29e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.15  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  171 QQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRsQEIDDHQHEMSVLQNAHQQKLTEI 250
Cdd:COG4717   108 EAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELE-EELEELEAELAELQEELEELLEQL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  251 SRRHREELSDYEERIEELENLLQQggsgvIETDLSKIYEMQKTIQVlQIEKVESTKKMEQLEDKIKD------------- 317
Cdd:COG4717   187 SLATEEELQDLAEELEELQQRLAE-----LEEELEEAQEELEELEE-ELEQLENELEAAALEERLKEarlllliaaalla 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  318 --------------------------------INKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLecsklqpsav 365
Cdd:COG4717   261 llglggsllsliltiagvlflvlgllallfllLAREKASLGKEAEELQALPALEELEEEELEELLAALGL---------- 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  366 kqsDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSL-----AEDNLKLKMRIEVLEKEKSLLsQEKEE 440
Cdd:COG4717   331 ---PPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALlaeagVEDEEELRAALEQAEEYQELK-EELEE 406

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  441 LQMSLLKLNNEYEVIKSTATRDiSLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQ-EATKHMILIKDQLS 519
Cdd:COG4717   407 LEEQLEELLGELEELLEALDEE-ELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGElAELLQELEELKAEL 485

                         410       420
                  ....*....|....*....|....*.
gi 190194412  520 KQQNEGDSIISKLKQDLNDEKKRVHQ 545
Cdd:COG4717   486 RELAEEWAALKLALELLEEAREEYRE 511
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 205-442 1.39e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.14  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   205 NSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDL 284
Cdd:pfam12128  660 DEKQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIA 739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   285 SKIYEMQKTIQVLQIEKVESTKK-------MEQLEDKIKDINKKLSSAENDRDILRR----EQEQLNVEKRQIMEECENL 353
Cdd:pfam12128  740 ARRSGAKAELKALETWYKRDLASlgvdpdvIAKLKREIRTLERKIERIAVRRQEVLRyfdwYQETWLQRRPRLATQLSNI 819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   354 KLECSKLQPS-AVKQSDTMTEKERILAQS-ASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEK 431
Cdd:pfam12128  820 ERAISELQQQlARLIADTKLRRAKLEMERkASEKQQVRLSENLRGLRCEMSKLATLKEDANSEQAQGSIGERLAQLEDLK 899

                          250
                   ....*....|.
gi 190194412   432 SLLSQEKEELQ 442
Cdd:pfam12128  900 LKRDYLSESVK 910
GRAB pfam10375
GRAB domain; The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type ...
 1774-1819 8.19e-04

GRAB domain; The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type proteins. This domain is related to the GRIP domain, but the conserved tyrosine residue found at position 4 in all GRIP domains is replaced by a leucine residue. The Arf small GTPase is localized to the cis-Golgi where it recruits proteins via their GRAB domain, as part of the transport of cargo from the endoplasmic reticulum to the plasma membrane.


Pssm-ID: 431241  Cd Length: 49  Bit Score: 39.13  E-value: 8.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 190194412  1774 SSEGKVDKVLMRNLFIGHFHTPK--NQRHEVLRLMGSILGVRREEMEQ 1819
Cdd:pfam10375    1 SSEDTVDRQLVTNLLLSFLSIPRgdTKKFEILQLIANLLEWDDEQREQ 48
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
 64-123 6.58e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 37.53  E-value: 6.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   64 LRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLK 123
Cdd:cd11400    16 LKNSFEKLRDLVPELADNEKASKVVILKKATEYIKQLQQEEKKLEKEKDKLKARNEQLRK 75
 
Name Accession Description Interval E-value
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 394-1235 2.06e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 85.88  E-value: 2.06e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   394 LSDAENEIMR-LSSLNQDNSLAEDNLKLKMRIEvlEKEKSLLSQEKEELQMSLLKLN---NEYEVIKSTATRDIS-LDSE 468
Cdd:TIGR02168  191 LEDILNELERqLKSLERQAEKAERYKELKAELR--ELELALLVLRLEELREELEELQeelKEAEEELEELTAELQeLEEK 268

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   469 LHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMilikDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLED 548
Cdd:TIGR02168  269 LEELRLEVSELEEEIEELQKELYALANEISRLEQQKQILRERL----ANLERQLEELEAQLEELESKLDELAEELAELEE 344

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   549 DKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELM 628
Cdd:TIGR02168  345 KLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIE 424

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   629 QSLNQDSNSNFKDT---------LLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKL---VLACEDVRHQLE-- 694
Cdd:TIGR02168  425 ELLKKLEEAELKELqaeleeleeELEELQEELERLEEALEELREELEEAEQALDAAERELAQLqarLDSLERLQENLEgf 504

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   695 -----ECLAGNNQLSLEKNTIVETLKMEKG---EIEAELCWAKKRLL-EEANKYEKTIEELSNARNLNTSALQLEHEHLI 765
Cdd:TIGR02168  505 segvkALLKNQSGLSGILGVLSELISVDEGyeaAIEAALGGRLQAVVvENLNAAKKAIAFLKQNELGRVTFLPLDSIKGT 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   766 KLnQKKDMEIAELKKNIEQMDTDHKETKDVLS-------------SSLEEQKQLTQLINKKEIFI----EKLKERSSKLQ 828
Cdd:TIGR02168  585 EI-QGNDREILKNIEGFLGVAKDLVKFDPKLRkalsyllggvlvvDDLDNALELAKKLRPGYRIVtldgDLVRPGGVITG 663

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   829 EELDKYSQAL-RKNEI--LRQTIEEKDRSLGSMKEENNhlqeelerlreeqsrtapvadpKTLDSVTELASEVSQLNTIK 905
Cdd:TIGR02168  664 GSAKTNSSILeRRREIeeLEEKIEELEEKIAELEKALA----------------------ELRKELEELEEELEQLRKEL 721

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   906 EHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDE---EIKSLQKTIEQIKTQLHEE 982
Cdd:TIGR02168  722 EELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEaeaEIEELEAQIEQLKEELKAL 801

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   983 RQDIqTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLvkgIKERELEIKLLNEKNISLTKQIDQLskdevgkltqiiq 1062
Cdd:TIGR02168  802 REAL-DELRAELTLLNEEAANLRERLESLERRIAATERR---LEDLEEQIEELSEDIESLAAEIEEL------------- 864

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1063 qkDLEIQALHARIssTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKK 1142
Cdd:TIGR02168  865 --EELIEELESEL--EALLNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDN 940

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1143 LSTRFESSGQDMFRETIQNLSriirekdiEIDALSQKCQTLLAVLQTSStgNEAGGVNSN---QFEELLQERDKLKQQVK 1219
Cdd:TIGR02168  941 LQERLSEEYSLTLEEAEALEN--------KIEDDEEEARRRLKRLENKI--KELGPVNLAaieEYEELKERYDFLTAQKE 1010

                          890
                   ....*....|....*.
gi 190194412  1220 KMEEWKQQVMTTVQNM 1235
Cdd:TIGR02168 1011 DLTEAKETLEEAIEEI 1026
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 244-1068 8.90e-16

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 83.95  E-value: 8.90e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   244 QQKLTEISRRHREELS---------DYEERIEELENLLQQggsgvIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDK 314
Cdd:TIGR02168  208 QAEKAERYKELKAELRelelallvlRLEELREELEELQEE-----LKEAEEELEELTAELQELEEKLEELRLEVSELEEE 282

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   315 IKDINKKLSSaendrdiLRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFR----- 389
Cdd:TIGR02168  283 IEELQKELYA-------LANEISRLEQQKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKeeles 355

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   390 LQQALSDAENEIMRLSSLNQD-----NSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEvikstATRDIS 464
Cdd:TIGR02168  356 LEAELEELEAELEELESRLEEleeqlETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIE-----ELLKKL 430

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   465 LDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISkLKQDLNDEKKRVH 544
Cdd:TIGR02168  431 EEAELKELQAELEELEEELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLER-LQENLEGFSEGVK 509

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   545 QLEDDKMDITKELDVQKEKL---IQSEVALNDLhltkqkLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRqneeELS 621
Cdd:TIGR02168  510 ALLKNQSGLSGILGVLSELIsvdEGYEAAIEAA------LGGRLQAVVVENLNAAKKAIAFLKQNELGRVTFL----PLD 579

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   622 RIRNELMQSLNQDSNSNFKDTL-----LKEREAEVRNLKQNL-------SELEQLNENLKKVAFDVKM------------ 677
Cdd:TIGR02168  580 SIKGTEIQGNDREILKNIEGFLgvakdLVKFDPKLRKALSYLlggvlvvDDLDNALELAKKLRPGYRIvtldgdlvrpgg 659

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   678 -------ENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEeankyektIEELSNAR 750
Cdd:TIGR02168  660 vitggsaKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEE--------LSRQISAL 731

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   751 NLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEE 830
Cdd:TIGR02168  732 RKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAE 811

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   831 L----DKYSQALRKNEILRQTIEEKDRSLGSMKEENNhlqeelerlreeqsrtapvadpKTLDSVTELASEVSQLNTIKE 906
Cdd:TIGR02168  812 LtllnEEAANLRERLESLERRIAATERRLEDLEEQIE----------------------ELSEDIESLAAEIEELEELIE 869

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   907 HLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQheqmnathtqlFLEKDEEIKSLQKTIEQIKTQLHEERQDI 986
Cdd:TIGR02168  870 ELESELEALLNERASLEEALALLRSELEELSEELRELESK-----------RSELRRELEELREKLAQLELRLEGLEVRI 938

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   987 QTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKER-----------ELEIKLLNEKNISLTKQIDQLSKdEVG 1055
Cdd:TIGR02168  939 DNLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKikelgpvnlaaIEEYEELKERYDFLTAQKEDLTE-AKE 1017

                          890
                   ....*....|...
gi 190194412  1056 KLTQIIQQKDLEI 1068
Cdd:TIGR02168 1018 TLEEAIEEIDREA 1030
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 298-1147 2.19e-15

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 82.71  E-value: 2.19e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   298 QIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERI 377
Cdd:pfam02463  169 RKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQELLRD 248

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   378 LAQSasveevFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKlKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKS 457
Cdd:pfam02463  249 EQEE------IESSKQEIEKEEEKLAQVLKENKEEEKEKKLQ-EEELKLLAKEEEELKSELLKLERRKVDDEEKLKESEK 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   458 TATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLN 537
Cdd:pfam02463  322 EKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKS 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   538 DEKKRV---HQLEDDKMDITKELDVQKEKL---IQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKE 611
Cdd:pfam02463  402 EEEKEAqllLELARQLEDLLKEEKKEELEIleeEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVK 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   612 HIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRH 691
Cdd:pfam02463  482 LQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKDGVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVE 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   692 QLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKK 771
Cdd:pfam02463  562 ERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKESA 641

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   772 DMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQaLRKNEILRQTIEEK 851
Cdd:pfam02463  642 KAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQ-REKEELKKLKLEAE 720

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   852 DRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQ 931
Cdd:pfam02463  721 ELLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQE 800

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   932 -SLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEK 1010
Cdd:pfam02463  801 eELRALEEELKEEAELLEEEQLLIEQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELE 880

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1011 HDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQ-----QKDLEIQALHARISSTSHTQDVV 1085
Cdd:pfam02463  881 EQKLKDELESKEEKEKEEKKELEEESQKLNLLEEKENEIEERIKEEAEILLKyeeepEELLLEEADEKEKEENNKEEEEE 960

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190194412  1086 YLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRF 1147
Cdd:pfam02463  961 RNKRLLLAKEELGKVNLMAIEEFEEKEERYNKDELEKERLEEEKKKLIRAIIEETCQRLKEF 1022
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 226-986 1.94e-13

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 76.25  E-value: 1.94e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   226 SQEIDDHQHEMSVLQ-NAHQQKLteisRRHREELSDYEERIEELENLLQQGGSGVIETDLsKIYEMQKTIQVLQ------ 298
Cdd:TIGR02168  219 KAELRELELALLVLRlEELREEL----EELQEELKEAEEELEELTAELQELEEKLEELRL-EVSELEEEIEELQkelyal 293

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   299 ---IEKVESTK-----KMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDT 370
Cdd:TIGR02168  294 aneISRLEQQKqilreRLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESR 373

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   371 MTEKERILAQSASveEVFRLQQALSDAENEIMRLSSlnQDNSLAEDNLKLKMRIEVLEKEksLLSQEKEELQMSLLKLNn 450
Cdd:TIGR02168  374 LEELEEQLETLRS--KVAQLELQIASLNNEIERLEA--RLERLEDRRERLQQEIEELLKK--LEEAELKELQAELEELE- 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   451 eyEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKdQLSKQQNEGDSIIS 530
Cdd:TIGR02168  447 --EELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVK-ALLKNQSGLSGILG 523

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   531 KLKQDLNDEKK-----------RVHQLEDDKMDITK-----------------ELDVQKEKLIQSE------------VA 570
Cdd:TIGR02168  524 VLSELISVDEGyeaaieaalggRLQAVVVENLNAAKkaiaflkqnelgrvtflPLDSIKGTEIQGNdreilkniegflGV 603

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   571 LNDLHLTKQKLEDKVENLVDQLN--KSQESNVSIQKENLELKEHIRQNEEELSR-------IRNELMQSLNQDSNSNFKD 641
Cdd:TIGR02168  604 AKDLVKFDPKLRKALSYLLGGVLvvDDLDNALELAKKLRPGYRIVTLDGDLVRPggvitggSAKTNSSILERRREIEELE 683

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   642 TLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
Cdd:TIGR02168  684 EKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEI 763

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   722 E------AELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQkkdmEIAELKKNIEQMDTDHKETKDV 795
Cdd:TIGR02168  764 EeleerlEEAEEELAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNE----EAANLRERLESLERRIAATERR 839

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   796 LSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLgsMKEENNHLQEELERLREE 875
Cdd:TIGR02168  840 LEDLEEQIEELSEDIESLAAEIEELEELIEELESELEALLNERASLEEALALLRSELEEL--SEELRELESKRSELRREL 917

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   876 QSRTAPVAdpktlDSVTELASEVSQLNTIKEHL-------EEEIKHHQKIIEDQNQSKMQLLQSLQEQKKE--------M 940
Cdd:TIGR02168  918 EELREKLA-----QLELRLEGLEVRIDNLQERLseeysltLEEAEALENKIEDDEEEARRRLKRLENKIKElgpvnlaaI 992

                          810       820       830       840       850
                   ....*....|....*....|....*....|....*....|....*....|.
gi 190194412   941 DEFRYQHEQMNathtqlFLEK-----DEEIKSLQKTIEQIKTQLHEERQDI 986
Cdd:TIGR02168  993 EEYEELKERYD------FLTAqkedlTEAKETLEEAIEEIDREARERFKDT 1037
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 423-979 5.37e-13

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 74.59  E-value: 5.37e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  423 RIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRdisLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDR 502
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEE---LRLELEELELELEEAQAEEYELLAELARLEQDIARLEE 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  503 QNQEATKHmiliKDQLSKQQNEgdsiiskLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLE 582
Cdd:COG1196   310 RRRELEER----LEELEEELAE-------LEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAE 378

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  583 DKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDsnsnfkDTLLKEREAEVRNLKQNLSELE 662
Cdd:COG1196   379 EELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEAL------AELEEEEEEEEEALEEAAEEEA 452

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  663 QLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKT 742
Cdd:COG1196   453 ELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGV 532

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  743 IEELSNArnLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKE 822
Cdd:COG1196   533 EAAYEAA--LEAALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLRE 610

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  823 RSSK-------LQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQS--RTAPVADPKTLDSVTE 893
Cdd:COG1196   611 ADARyyvlgdtLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAalLEAEAELEELAERLAE 690

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  894 LASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE 973
Cdd:COG1196   691 EELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEELERELE 770


                  ....*.
gi 190194412  974 QIKTQL 979
Cdd:COG1196   771 RLEREI 776
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 482-1033 6.14e-13

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 74.29  E-value: 6.14e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   482 ELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSI---ISKLKQDLNDEKKRVHQLEDDKMDITKELD 558
Cdd:TIGR04523  111 EIKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLnnkYNDLKKQKEELENELNLLEKEKLNIQKNID 190

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   559 VQKEKLIQSEVALNDLHLTKQK---LEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDS 635
Cdd:TIGR04523  191 KIKNKLLKLELLLSNLKKKIQKnksLESQISELKKQNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLS 270

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   636 NSNFK----DTLLKEREAEVRNLKQNLSELEQLNEN--LKKVAFDVKMENEKLVlacedvrhQLEECLAGNNQLSLEKNT 709
Cdd:TIGR04523  271 EKQKEleqnNKKIKELEKQLNQLKSEISDLNNQKEQdwNKELKSELKNQEKKLE--------EIQNQISQNNKIISQLNE 342

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   710 IVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEE----LSNARNLNT--SALQLEHEHLIKLNQKKDMEIAELKKNIE 783
Cdd:TIGR04523  343 QISQLKKELTNSESENSEKQRELEEKQNEIEKLKKEnqsyKQEIKNLESqiNDLESKIQNQEKLNQQKDEQIKKLQQEKE 422

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   784 QMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKN----EILRQTIEEKDRSLGSMK 859
Cdd:TIGR04523  423 LLEKEIERLKETIIKNNSEIKDLTNQDSVKELIIKNLDNTRESLETQLKVLSRSINKIkqnlEQKQKELKSKEKELKKLN 502

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   860 EENNHLQEELERLREEQSrtapvadpKTLDSVTELASEVSQLNTIKEHLEEEIKHhqkiiEDQNQSKMQLLQSLQEQKKE 939
Cdd:TIGR04523  503 EEKKELEEKVKDLTKKIS--------SLKEKIEKLESEKKEKESKISDLEDELNK-----DDFELKKENLEKEIDEKNKE 569

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   940 MDEFRYQHEQMNATHTqlflEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIfQETKVQSLNIENGSEKHDLSKAETE 1019
Cdd:TIGR04523  570 IEELKQTQKSLKKKQE----EKQELIDQKEKEKKDLIKEIEEKEKKISSLEKEL-EKAKKENEKLSSIIKNIKSKKNKLK 644

                          570
                   ....*....|....
gi 190194412  1020 RLVKGIKERELEIK 1033
Cdd:TIGR04523  645 QEVKQIKETIKEIR 658
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 412-725 1.04e-12

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 73.95  E-value: 1.04e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   412 SLAEDNLKLKMRIEVLEKEKSLLSQEKEELQmsllKLNNEYEVIKSTATRDISldsELHDLRLNLEAKEQELNQSISEKE 491
Cdd:TIGR02169  671 SEPAELQRLRERLEGLKRELSSLQSELRRIE----NRLDELSQELSDASRKIG---EIEKEIEQLEQEEEKLKERLEELE 743

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   492 TLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEkkRVHQLEDDKMDITKELDVQKEKLIQSEVAL 571
Cdd:TIGR02169  744 EDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHS--RIPEIQAELSKLEEEVSRIEARLREIEQKL 821

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   572 NDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQdsnsnfkdtlLKEREAEV 651
Cdd:TIGR02169  822 NRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESR----------LGDLKKER 891

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190194412   652 RNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQL--SLEKNTIVETLKMEKGEIEAEL 725
Cdd:TIGR02169  892 DELEAQLRELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGEDeeIPEEELSLEDVQAELQRVEEEI 967
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 213-853 1.87e-12

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 73.05  E-value: 1.87e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  213 KLQNIIKELKQN-RSQEIDDHQHEMSVLQNAHQQKLTEIsRRHREELSDYEERIEELEnllqqggsgvietdlSKIYEMQ 291
Cdd:COG1196   217 ELKEELKELEAElLLLKLRELEAELEELEAELEELEAEL-EELEAELAELEAELEELR---------------LELEELE 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  292 KTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTM 371
Cdd:COG1196   281 LELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAEL 360

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  372 TEKERILAQSASVEEvfRLQQALSDAENEIMRLssLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNE 451
Cdd:COG1196   361 AEAEEALLEAEAELA--EAEEELEELAEELLEA--LRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEE 436

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  452 YEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELdrQNQEATKHMILIKDQLSKQQNEGDSIISK 531
Cdd:COG1196   437 EEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEE--LAEAAARLLLLLEAEADYEGFLEGVKAAL 514

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  532 LKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENL----VDQLNKSQESNVSIQKENL 607
Cdd:COG1196   515 LLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAKAgratFLPLDKIRARAALAAALAR 594

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  608 ELKEHIRQNEEELSRIRNELMQslnqdsnsNFKDTLLkEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACE 687
Cdd:COG1196   595 GAIGAAVDLVASDLREADARYY--------VLGDTLL-GRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGG 665

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  688 DVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELcwakKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKL 767
Cdd:COG1196   666 SRRELLAALLEAEAELEELAERLAEEELELEEALLAEE----EEERELAEAEEERLEEELEEEALEEQLEAEREELLEEL 741

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  768 NQKKDMEIAELKKNIEQMDtdhketkdvlssSLEEQKQLTQLINKKeifIEKL--------------KERSSKLQEELDK 833
Cdd:COG1196   742 LEEEELLEEEALEELPEPP------------DLEELERELERLERE---IEALgpvnllaieeyeelEERYDFLSEQRED 806

                         650       660
                  ....*....|....*....|
gi 190194412  834 YSQALRKneiLRQTIEEKDR 853
Cdd:COG1196   807 LEEARET---LEEAIEEIDR 823
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 908-1752 7.57e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.86  E-value: 7.57e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   908 LEEEIKHHQKII-----EDQNQSKMQLLQSLQEQKKEMDEFRyqhEQMNATHTQL------FLEKDEEIKSLQKTIEQIK 976
Cdd:TIGR02168  218 LKAELRELELALlvlrlEELREELEELQEELKEAEEELEELT---AELQELEEKLeelrleVSELEEEIEELQKELYALA 294

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   977 TQLHEERQDIQ-TDNSDIFQETKVQSLN--IENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDE 1053
Cdd:TIGR02168  295 NEISRLEQQKQiLRERLANLERQLEELEaqLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRL 374

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1054 VGKLTQIIQQKDLEIQALHARissTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMdiVAAKEAAL 1133
Cdd:TIGR02168  375 EELEEQLETLRSKVAQLELQI---ASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAE--LEELEEEL 449

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1134 IKLQDENKKLSTRFESSgqdmfRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELLQERDK 1213
Cdd:TIGR02168  450 EELQEELERLEEALEEL-----REELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGV 524

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1214 LKQQVKKMEEWKQQVmttvqnmqheSAQLQEELhqlqaQVLVDSDNNSKLQvdytgLIQSYEQNETKLKNF-------GQ 1286
Cdd:TIGR02168  525 LSELISVDEGYEAAI----------EAALGGRL-----QAVVVENLNAAKK-----AIAFLKQNELGRVTFlpldsikGT 584

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1287 ELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSAslLTPQSAECLRASksevlsesselLQQELEELRKSLQEKdATIRTL 1366
Cdd:TIGR02168  585 EIQGNDREILKNIEGFLGVAKDLVKFDPKLRKA--LSYLLGGVLVVD-----------DLDNALELAKKLRPG-YRIVTL 650

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1367 QENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTN 1446
Cdd:TIGR02168  651 DGDLVRPGGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELEELEEELEQLRKELEELSRQISA 730

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1447 LKERILILEMDIGKLkgenekivetyrgkETEYQALQETNMKfsmmLREKEFECHSMKEKALAFEQLLKEKEQGKTGELN 1526
Cdd:TIGR02168  731 LRKDLARLEAEVEQL--------------EERIAQLSKELTE----LEAEIEELEERLEEAEEELAEAEAEIEELEAQIE 792

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1527 QLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRnhllESEDSYTREALAAEDRE 1606
Cdd:TIGR02168  793 QLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIEELS----EDIESLAAEIEELEELI 868

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1607 AKLRKKVTVLEEKLvsssNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQE 1686
Cdd:TIGR02168  869 EELESELEALLNER----ASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRIDNLQER 944

                          810       820       830       840       850       860       870
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1687 EKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEAN----AALDSASRLTEQLDVKEEQIEELKR 1752
Cdd:TIGR02168  945 LSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGpvnlAAIEEYEELKERYDFLTAQKEDLTE 1014
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 476-1253 9.12e-12

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 70.86  E-value: 9.12e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   476 LEAKEQELNQSISEKETliaEIEELDRQnqeatkhmiliKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITK 555
Cdd:TIGR02168  237 LREELEELQEELKEAEE---ELEELTAE-----------LQELEEKLEELRLEVSELEEEIEELQKELYALANEISRLEQ 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   556 ELDVQKEKL----IQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIR--NELMQ 629
Cdd:TIGR02168  303 QKQILRERLanleRQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEelEEQLE 382

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   630 SLNQDSNsnfkdtLLKEREAEVRN-LKQNLSELEQLNENLKkvafdvKMENEKLVLACEDVRHQLEECLAGNNqlslEKN 708
Cdd:TIGR02168  383 TLRSKVA------QLELQIASLNNeIERLEARLERLEDRRE------RLQQEIEELLKKLEEAELKELQAELE----ELE 446

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   709 TIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHliklnQKKDMEIAELKKNIEQMDTD 788
Cdd:TIGR02168  447 EELEELQEELERLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENL-----EGFSEGVKALLKNQSGLSGI 521

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   789 HketkDVLSSSLEEQKQLTQLINKkeifieKLKERSSKL----QEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNH 864
Cdd:TIGR02168  522 L----GVLSELISVDEGYEAAIEA------ALGGRLQAVvvenLNAAKKAIAFLKQNELGRVTFLPLDSIKGTEIQGNDR 591

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   865 LQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLE--EEIKHHQKIIEDQ----------NQSKMQLLQS 932
Cdd:TIGR02168  592 EILKNIEGFLGVAKDLVKFDPKLRKALSYLLGGVLVVDDLDNALElaKKLRPGYRIVTLDgdlvrpggviTGGSAKTNSS 671

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   933 LQEQKKEMDEFRYQHEQMnathTQLFLEKDEEIKSLQKTIEQIKTQLHEER---QDIQTDNSDIFQETKVQSLNIENGSE 1009
Cdd:TIGR02168  672 ILERRREIEELEEKIEEL----EEKIAELEKALAELRKELEELEEELEQLRkelEELSRQISALRKDLARLEAEVEQLEE 747

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1010 KHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLsKDEVGKLTQIIQQKDLEIQALHARISSTS-HTQDVVYLQ 1088
Cdd:TIGR02168  748 RIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEEL-EAQIEQLKEELKALREALDELRAELTLLNeEAANLRERL 826

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1089 QQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMdivAAKEAALIKLQDENKKLSTRFESSGQDM--FRETIQNLSRII 1166
Cdd:TIGR02168  827 ESLERRIAATERRLEDLEEQIEELSEDIESLAAEI---EELEELIEELESELEALLNERASLEEALalLRSELEELSEEL 903

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1167 REKDIEIDALSQKCQTLlavlqtsstgNEAGGVNSNQFEELLQERDKLKQQVkkMEEWK---QQVMTTVQNMQHESAQLQ 1243
Cdd:TIGR02168  904 RELESKRSELRRELEEL----------REKLAQLELRLEGLEVRIDNLQERL--SEEYSltlEEAEALENKIEDDEEEAR 971

                          810
                   ....*....|
gi 190194412  1244 EELHQLQAQV 1253
Cdd:TIGR02168  972 RRLKRLENKI 981
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 307-627 1.06e-10

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 67.40  E-value: 1.06e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   307 KMEQLEDKIKDINKKLSSAENDRDILRREQEQLnvEKRQIMEEcenlKLECSKLQPSAVKQSDTMTEKERILAQSASVEE 386
Cdd:TIGR02169  178 ELEEVEENIERLDLIIDEKRQQLERLRREREKA--ERYQALLK----EKREYEGYELLKEKEALERQKEAIERQLASLEE 251

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   387 VF---------------RLQQALSDAENEIMRLSSlNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNE 451
Cdd:TIGR02169  252 ELeklteeiselekrleEIEQLLEELNKKIKDLGE-EEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAE 330

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   452 YEVIKSTATrdiSLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISK 531
Cdd:TIGR02169  331 IDKLLAEIE---ELEREIEEERKRRDKLTEEYAELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRE 407

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   532 LKQDLNDEKKRVHQLEDDKMDITkeldVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKsqesnvsIQKENLELKE 611
Cdd:TIGR02169  408 LDRLQEELQRLSEELADLNAAIA----GIEAKINELEEEKEDKALEIKKQEWKLEQLAADLSK-------YEQELYDLKE 476

                          330
                   ....*....|....*.
gi 190194412   612 HIRQNEEELSRIRNEL 627
Cdd:TIGR02169  477 EYDRVEKELSKLQREL 492
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 196-646 2.67e-10

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 65.81  E-value: 2.67e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   196 QTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNaHQQKLTEISRRHREELSDYEERIEELENLLQQG 275
Cdd:TIGR04523  226 QNNQLKDNIEKKQQEINEKTTEISNTQTQLNQLKDEQNKIKKQLSE-KQKELEQNNKKIKELEKQLNQLKSEISDLNNQK 304

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   276 GSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKL 355
Cdd:TIGR04523  305 EQDWNKELKSELKNQEKKLEEIQNQISQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQ 384

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   356 ECSKLQPSAVKQSDTMTEKERILAQSAsvEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKmrIEVLEKEKSLLS 435
Cdd:TIGR04523  385 EIKNLESQINDLESKIQNQEKLNQQKD--EQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQ--DSVKELIIKNLD 460

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   436 QEKEELQMSLLKLNNEYEVIKStatrdisldselhdlrlNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIK 515
Cdd:TIGR04523  461 NTRESLETQLKVLSRSINKIKQ-----------------NLEQKQKELKSKEKELKKLNEEKKELEEKVKDLTKKISSLK 523

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   516 ---DQLSKQQNEGDSIISKLKQDLNDEK----------------KRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHL 576
Cdd:TIGR04523  524 ekiEKLESEKKEKESKISDLEDELNKDDfelkkenlekeideknKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIK 603

                          410       420       430       440       450       460       470
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   577 TKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKE 646
Cdd:TIGR04523  604 EIEEKEKKISSLEKELEKAKKENEKLSSIIKNIKSKKNKLKQEVKQIKETIKEIRNKWPEIIKKIKESKT 673
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
213-830 1.92e-09

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 62.77  E-value: 1.92e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  213 KLQNIIKELKQNRSQEIDDHQHEMSV--LQNAHQQKLTEISRRHREELSDYEERIEELENLlqqggsgviETDLSKIYEM 290
Cdd:PRK03918  166 NLGEVIKEIKRRIERLEKFIKRTENIeeLIKEKEKELEEVLREINEISSELPELREELEKL---------EKEVKELEEL 236

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  291 QKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSsaendrdilrreqeqlnvEKRQIMEECENLKLECSKLQPSAVKQSDT 370
Cdd:PRK03918  237 KEEIEELEKELESLEGSKRKLEEKIRELEERIE------------------ELKKEIEELEEKVKELKELKEKAEEYIKL 298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  371 MTEKERILAQSASVEEvfRLQQALSDAENEIMRLSSLNQDNSLAEdnlKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN 450
Cdd:PRK03918  299 SEFYEEYLDELREIEK--RLSRLEEEINGIEERIKELEEKEERLE---ELKKKLKELEKRLEELEERHELYEEAKAKKEE 373

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  451 EYEVIKSTATRDIS-LDSELHDL---RLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGd 526
Cdd:PRK03918  374 LERLKKRLTGLTPEkLEKELEELekaKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPVCGRELTEEHRKE- 452

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  527 sIISKLKQDLNDEKKRVHQLEDDKMDITKELdVQKEKLIQSEVALNDLHltkqKLEDKVENLVDQLNKSQESNVSIQKEN 606
Cdd:PRK03918  453 -LLEEYTAELKRIEKELKEIEEKERKLRKEL-RELEKVLKKESELIKLK----ELAEQLKELEEKLKKYNLEELEKKAEE 526

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  607 LE-LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSEL-----EQLNENLKKVAfdvKMENE 680
Cdd:PRK03918  527 YEkLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDELEEELAELLKELEELgfesvEELEERLKELE---PFYNE 603

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  681 KLVLacEDVRHQLEECLagnNQLSLEKNTIVETLKmEKGEIEAELCWAKKRLLEEANKYEKtiEELSNARNLNTSalqLE 760
Cdd:PRK03918  604 YLEL--KDAEKELEREE---KELKKLEEELDKAFE-ELAETEKRLEELRKELEELEKKYSE--EEYEELREEYLE---LS 672

                         570       580       590       600       610       620       630
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190194412  761 HEHLIKLNQKKDME--IAELKKNIEQMdtdhKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEE 830
Cdd:PRK03918  673 RELAGLRAELEELEkrREEIKKTLEKL----KEELEEREKAKKELEKLEKALERVEELREKVKKYKALLKER 740
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 242-981 2.41e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 62.78  E-value: 2.41e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   242 AHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKK 321
Cdd:TIGR02169  251 EELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEAE 330

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   322 LSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAvkQSDTMTEKERILAQSASVEEVFRLQQALSDAENEI 401
Cdd:TIGR02169  331 IDKLLAEIEELEREIEEERKRRDKLTEEYAELKEELEDLRAEL--EEVDKEFAETRDELKDYREKLEKLKREINELKREL 408

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   402 MRLSSLNQdnSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEyevIKSTATRDISLDSELHDLRLNLEAKEQ 481
Cdd:TIGR02169  409 DRLQEELQ--RLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWK---LEQLAADLSKYEQELYDLKEEYDRVEK 483

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   482 ELNQSISEKETLIAEIEELDRQNQEATKHMILIKD----------QLSKQQNE---------GDSIISKLKQDLNDEKKR 542
Cdd:TIGR02169  484 ELSKLQRELAEAEAQARASEERVRGGRAVEEVLKAsiqgvhgtvaQLGSVGERyataievaaGNRLNNVVVEDDAVAKEA 563

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   543 VHQLEDDK------MDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLV--------------------------- 589
Cdd:TIGR02169  564 IELLKRRKagratfLPLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKYEPAFkyvfgdtlvvedieaarrlmgkyrmvt 643

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   590 ---DQLNKS---------QESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLN-QDSNSNFKDTLLKEREAEVRNLKQ 656
Cdd:TIGR02169  644 legELFEKSgamtggsraPRGGILFSRSEPAELQRLRERLEGLKRELSSLQSELRrIENRLDELSQELSDASRKIGEIEK 723

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   657 NLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEA 736
Cdd:TIGR02169  724 EIEQLEQEEEKLKERLEELEEDLSSLEQEIENVKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKL 803

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   737 NKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEqmdtDHKETKDVLSSSLEEqkqLTQLINKKEIF 816
Cdd:TIGR02169  804 EEEVSRIEARLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIK----SIEKEIENLNGKKEE---LEEELEELEAA 876

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   817 IEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKdrslgsMKEENNHLQEELERLREEQSRTAPVADPKTLDsvtelaS 896
Cdd:TIGR02169  877 LRDLESRLGDLKKERDELEAQLRELERKIEELEAQ------IEKKRKRLSELKAKLEALEEELSEIEDPKGED------E 944

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   897 EVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMnathtqlflekDEEIKSLQKTIEQIK 976
Cdd:TIGR02169  945 EIPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRAKL-----------EEERKAILERIEEYE 1013


                   ....*
gi 190194412   977 TQLHE 981
Cdd:TIGR02169 1014 KKKRE 1018
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 373-975 2.57e-09

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 62.65  E-value: 2.57e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  373 EKERILAQSASVEEVFRLQQALSDAENEImrlsslnqdNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEY 452
Cdd:COG1196   220 EELKELEAELLLLKLRELEAELEELEAEL---------EELEAELEELEAELAELEAELEELRLELEELELELEEAQAEE 290

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  453 EVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISE----KETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEgdsi 528
Cdd:COG1196   291 YELLAELARLEQDIARLEERRRELEERLEELEEELAEleeeLEELEEELEELEEELEEAEEELEEAEAELAEAEEA---- 366

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  529 ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLE 608
Cdd:COG1196   367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEE 446

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  609 LKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNE-NLKKVAFDVKMENEKLVLACE 687
Cdd:COG1196   447 AAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEgFLEGVKAALLLAGLRGLAGAV 526

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  688 DVRHQLEECL---AGNNQLSLEKNTIVETLKMEKGEIEaelcWAKKRLLEEANKYEKT-IEELSNARNLNTSALQLEHEH 763
Cdd:COG1196   527 AVLIGVEAAYeaaLEAALAAALQNIVVEDDEVAAAAIE----YLKAAKAGRATFLPLDkIRARAALAAALARGAIGAAVD 602

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  764 LIKLNQKKDMEIAELKKNI---EQMDTDHKETKDVLSSSLEEQKQLTQLinKKEIFIEKLKERSSKLQEELDKYSQALRK 840
Cdd:COG1196   603 LVASDLREADARYYVLGDTllgRTLVAARLEAALRRAVTLAGRLREVTL--EGEGGSAGGSLTGGSRRELLAALLEAEAE 680

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  841 NEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE 920
Cdd:COG1196   681 LEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPP 760

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190194412  921 DQNQSKmQLLQSLQEQKKEM--------DEFRYQHEQMNATHTQLfleKD--EEIKSLQKTIEQI 975
Cdd:COG1196   761 DLEELE-RELERLEREIEALgpvnllaiEEYEELEERYDFLSEQR---EDleEARETLEEAIEEI 821
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 611-1436 3.34e-09

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 62.38  E-value: 3.34e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   611 EHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLS--ELEQLNENLKKVAFDVKMENEKlvlaCED 688
Cdd:TIGR02168  182 ERTRENLDRLEDILNELERQLKSLERQAEKAERYKELKAELRELELALLvlRLEELREELEELQEELKEAEEE----LEE 257

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   689 VRHQLEECLAGNNQLSLEKNTivetLKMEKGEIEAELcwakKRLLEEANKYEKTIEELSNAR-NLNTSALQLEhEHLIKL 767
Cdd:TIGR02168  258 LTAELQELEEKLEELRLEVSE----LEEEIEELQKEL----YALANEISRLEQQKQILRERLaNLERQLEELE-AQLEEL 328

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   768 NQKKDM---EIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALrknEIL 844
Cdd:TIGR02168  329 ESKLDElaeELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQLETLRSKVAQLELQIASLNNEI---ERL 405

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   845 RQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDsvtELASEVSQLNTIKEHLEEEIKHHQKIIeDQNQ 924
Cdd:TIGR02168  406 EARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELE---ELQEELERLEEALEELREELEEAEQAL-DAAE 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   925 SKMQLLQSLQEQKKEMDEfryQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQ----------LHEERQDIQTDNSDIF 994
Cdd:TIGR02168  482 RELAQLQARLDSLERLQE---NLEGFSEGVKALLKNQSGLSGILGVLSELISVDegyeaaieaaLGGRLQAVVVENLNAA 558

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   995 QETkVQSLniengsEKHDLSKAeTERLVKGIKERELEIKLLNEKN---------ISLTKQIDQLSKDEVGKLTQIIQQKD 1065
Cdd:TIGR02168  559 KKA-IAFL------KQNELGRV-TFLPLDSIKGTEIQGNDREILKniegflgvaKDLVKFDPKLRKALSYLLGGVLVVDD 630

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1066 LEiQALHARiSSTSHTQDVVYLQQQL----QAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENK 1141
Cdd:TIGR02168  631 LD-NALELA-KKLRPGYRIVTLDGDLvrpgGVITGGSAKTNSSILERRREIEELEEKIEELEEKIAELEKALAELRKELE 708

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1142 KLSTRFESsgqdmFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTsstgneaggvNSNQFEELLQERDKLKQQVKKM 1221
Cdd:TIGR02168  709 ELEEELEQ-----LRKELEELSRQISALRKDLARLEAEVEQLEERIAQ----------LSKELTELEAEIEELEERLEEA 773

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1222 EEWKQQVMTtvqnmqhESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNT 1301
Cdd:TIGR02168  774 EEELAEAEA-------EIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQ 846

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1302 KDLLLGKLDIISPQLSSASLLTPQSAECL------RASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSD 1375
Cdd:TIGR02168  847 IEELSEDIESLAAEIEELEELIEELESELeallneRASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQ 926

                          810       820       830       840       850       860
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 190194412  1376 SIAATSELERKEHEQtdseIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNE 1436
Cdd:TIGR02168  927 LELRLEGLEVRIDNL----QERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKE 983
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 255-1002 7.05e-09

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 61.24  E-value: 7.05e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   255 REELSDYE--ERIEELENLLQQggsgvIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDI- 331
Cdd:TIGR02169  217 LKEKREYEgyELLKEKEALERQ-----KEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEELNKKIKDLGEEEQLr 291

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   332 LRREQEQLNVEKRQIMEECENLKLEcskLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRlsslnqdn 411
Cdd:TIGR02169  292 VKEKIGELEAEIASLERSIAEKERE---LEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEYA-------- 360

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   412 SLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDIS----LDSELHDLRLNLEAKEQELNQSI 487
Cdd:TIGR02169  361 ELKEELEDLRAELEEVDKEFAETRDELKDYREKLEKLKREINELKRELDRLQEelqrLSEELADLNAAIAGIEAKINELE 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   488 SEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSI---ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKL 564
Cdd:TIGR02169  441 EEKEDKALEIKKQEWKLEQLAADLSKYEQELYDLKEEYDRVekeLSKLQRELAEAEAQARASEERVRGGRAVEEVLKASI 520

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   565 IQSEVALNDLHLTKQKLEDKVEN-LVDQLNKSQESNVSIQKENLE-LKEH------------IRQNEEELSRIRNE---- 626
Cdd:TIGR02169  521 QGVHGTVAQLGSVGERYATAIEVaAGNRLNNVVVEDDAVAKEAIElLKRRkagratflplnkMRDERRDLSILSEDgvig 600

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   627 -LMQSLNQDSNSN------FKDTLLKEREAEVRNLkqnlseleqlnenLKKVAFdVKMENEKLVLACEDVRHQLEECLAG 699
Cdd:TIGR02169  601 fAVDLVEFDPKYEpafkyvFGDTLVVEDIEAARRL-------------MGKYRM-VTLEGELFEKSGAMTGGSRAPRGGI 666

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   700 NNQLSLEKNtiVETLKMEKGEIEAELcwakKRLLEEANKYEKTIEELSNARnlntSALQLEHEHLIKLNQKKDMEIAELK 779
Cdd:TIGR02169  667 LFSRSEPAE--LQRLRERLEGLKREL----SSLQSELRRIENRLDELSQEL----SDASRKIGEIEKEIEQLEQEEEKLK 736

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   780 KNIEQMDTDHKETKDVLSSSLEEQKQLtqlinkkEIFIEKLKERSSKLQEELDKYSQALRkneilRQTIEEKDRSLGSMK 859
Cdd:TIGR02169  737 ERLEELEEDLSSLEQEIENVKSELKEL-------EARIEELEEDLHKLEEALNDLEARLS-----HSRIPEIQAELSKLE 804

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   860 EENNHLQEelerlreeqsrtapvadpktldSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKE 939
Cdd:TIGR02169  805 EEVSRIEA----------------------RLREIEQKLNRLTLEKEYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGK 862

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 190194412   940 MDEFRYQHEQMNATHTQLflekDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSL 1002
Cdd:TIGR02169  863 KEELEEELEELEAALRDL----ESRLGDLKKERDELEAQLRELERKIEELEAQIEKKRKRLSE 921
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 552-1099 1.68e-08

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 59.95  E-value: 1.68e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  552 DITKELDVQKEKL-IQSEVA---------------------LNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLEL 609
Cdd:COG1196   193 DILGELERQLEPLeRQAEKAeryrelkeelkeleaellllkLRELEAELEELEAELEELEAELEELEAELAELEAELEEL 272

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  610 KEHIRQNEEELSRIRNELMQSLNQdsnsnfKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDV 689
Cdd:COG1196   273 RLELEELELELEEAQAEEYELLAE------LARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEEL 346

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  690 RHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAElcwakKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQ 769
Cdd:COG1196   347 EEAEEELEEAEAELAEAEEALLEAEAELAEAEEEL-----EELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEE 421

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  770 KKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIE 849
Cdd:COG1196   422 ELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEA 501

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  850 EKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDsvTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQL 929
Cdd:COG1196   502 DYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALE--AALAAALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPL 579

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  930 LQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIE---QIKTQLHEERQDIQTDNSDIFQETKVQSLNIEN 1006
Cdd:COG1196   580 DKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLgrtLVAARLEAALRRAVTLAGRLREVTLEGEGGSAG 659

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1007 GSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEvgKLTQIIQQKDLEIQALHARISSTSHTQDVVY 1086
Cdd:COG1196   660 GSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEE--RELAEAEEERLEEELEEEALEEQLEAEREEL 737

                         570
                  ....*....|...
gi 190194412 1087 LQQQLQAYAMERE 1099
Cdd:COG1196   738 LEELLEEEELLEE 750
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 54-853 2.68e-08

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 59.30  E-value: 2.68e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412    54 TKEIEAIHAILRSENERLKKLCTDLEEKHEASEiQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLKLQSAAQSVPS 133
Cdd:TIGR02168  294 ANEISRLEQQKQILRERLANLERQLEELEAQLE-ELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELES 372

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   134 GAgVPATTASSSFAygishhpsafhdddmdfGDIISSQQEINRLSNEVSRLESEVghwrhiaqtskaqgtdnsdqseick 213
Cdd:TIGR02168  373 RL-EELEEQLETLR-----------------SKVAQLELQIASLNNEIERLEARL------------------------- 409

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   214 lqNIIKELKQNRSQEIDDHQHEMSVLQ-NAHQQKLTEISRRHREELSDYEERIEELENLLQQggsgvIETDLSKIYEMQK 292
Cdd:TIGR02168  410 --ERLEDRRERLQQEIEELLKKLEEAElKELQAELEELEEELEELQEELERLEEALEELREE-----LEEAEQALDAAER 482

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   293 TIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRqiMEECENLKLEcSKLQPSAVKQSDTMT 372
Cdd:TIGR02168  483 ELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGLSGILGVLSELISVDEG--YEAAIEAALG-GRLQAVVVENLNAAK 559

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   373 EKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDN---SLAEDNLKLKMRIEVLekEKSLLSQEK--EELQ--MSL 445
Cdd:TIGR02168  560 KAIAFLKQNELGRVTFLPLDSIKGTEIQGNDREILKNIEgflGVAKDLVKFDPKLRKA--LSYLLGGVLvvDDLDnaLEL 637

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   446 LKLNNEYEVI------------------KSTATRDISLDSELHDLRLNLEAKEQElnqsISEKETLIAEIEELDRQNQEA 507
Cdd:TIGR02168  638 AKKLRPGYRIvtldgdlvrpggvitggsAKTNSSILERRREIEELEEKIEELEEK----IAELEKALAELRKELEELEEE 713

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   508 TKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVEN 587
Cdd:TIGR02168  714 LEQLRKELEELSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAEAEIEELEAQIEQ 793

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   588 LVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELmqslnqdsnsnfkDTLLKEREAEVRNLKQNLSELEQLNEN 667
Cdd:TIGR02168  794 LKEELKALREALDELRAELTLLNEEAANLRERLESLERRI-------------AATERRLEDLEEQIEELSEDIESLAAE 860

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   668 LKKVAFDVKMENEKLVLAcEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELS 747
Cdd:TIGR02168  861 IEELEELIEELESELEAL-LNERASLEEALALLRSELEELSEELRELESKRSELRRELEELREKLAQLELRLEGLEVRID 939

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   748 NARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEqkqltqlinkkeifIEKLKERSSKL 827
Cdd:TIGR02168  940 NLQERLSEEYSLTLEEAEALENKIEDDEEEARRRLKRLENKIKELGPVNLAAIEE--------------YEELKERYDFL 1005

                          810       820
                   ....*....|....*....|....*.
gi 190194412   828 QEELDKYSQALRKneiLRQTIEEKDR 853
Cdd:TIGR02168 1006 TAQKEDLTEAKET---LEEAIEEIDR 1028
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 213-1130 3.90e-08

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 58.90  E-value: 3.90e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   213 KLQNIIKELKQNRSQEIDDHQHEMSVLQNaHQQKLTEI-----SRRHREELS-----DYEERIEELENLLQQggsgvIET 282
Cdd:TIGR00606  186 KALETLRQVRQTQGQKVQEHQMELKYLKQ-YKEKACEIrdqitSKEAQLESSreivkSYENELDPLKNRLKE-----IEH 259

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   283 DLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDI---------------NKKLSSAENDRDILRREQEQLNVEKRQIM 347
Cdd:TIGR00606  260 NLSKIMKLDNEIKALKSRKKQMEKDNSELELKMEKVfqgtdeqlndlyhnhQRTVREKERELVDCQRELEKLNKERRLLN 339

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   348 EECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQAlSDAENEIMRLSSL------------NQDNSLAE 415
Cdd:TIGR00606  340 QEKTELLVEQGRLQLQADRHQEHIRARDSLIQSLATRLELDGFERG-PFSERQIKNFHTLvierqedeaktaAQLCADLQ 418

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   416 DNLKLKMR------------IEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRL-----NLEA 478
Cdd:TIGR00606  419 SKERLKQEqadeirdekkglGRTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKaeknsLTET 498

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   479 KEQELNQSISEKETLIAEIEELDRQNQEATKHMILIK--DQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKE 556
Cdd:TIGR00606  499 LKKEVKSLQNEKADLDRKLRKLDQEMEQLNHHTTTRTqmEMLTKDKMDKDEQIRKIKSRHSDELTSLLGYFPNKKQLEDW 578

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   557 LDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLnKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSN 636
Cdd:TIGR00606  579 LHSKSKEINQTRDRLAKLNKELASLEQNKNHINNEL-ESKEEQLSSYEDKLFDVCGSQDEESDLERLKEEIEKSSKQRAM 657

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   637 SNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKM 716
Cdd:TIGR00606  658 LAGATAVYSQFITQLTDENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQS 737

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   717 EKGEIEAELcwakKRLLEEANKYEKTIEELSNARNlntsalqlEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVl 796
Cdd:TIGR00606  738 IIDLKEKEI----PELRNKLQKVNRDIQRLKNDIE--------EQETLLGTIMPEEESAKVCLTDVTIMERFQMELKDV- 804

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   797 SSSLEEQKQLTQLINKKEIFIEKLKERSSKlQEELDKYSQalrKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQ 876
Cdd:TIGR00606  805 ERKIAQQAAKLQGSDLDRTVQQVNQEKQEK-QHELDTVVS---KIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNL 880

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   877 SRTAPVAdpktlDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEM--------DEFRYQHE 948
Cdd:TIGR00606  881 QRRQQFE-----EQLVELSTEVQSLIREIKDAKEQDSPLETFLEKDQQEKEELISSKETSNKKAqdkvndikEKVKNIHG 955

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   949 QMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIfqetKVQSLNIENGSEKHDLSKAETERLVkgikeR 1028
Cdd:TIGR00606  956 YMKDIENKIQDGKDDYLKQKETELNTVNAQLEECEKHQEKINEDM----RLMRQDIDTQKIQERWLQDNLTLRK-----R 1026

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1029 ELEIKLLNEKNISLTKQIDQLskdevgkltQIIQQKDlEIQALHARISSTSHTQDVVYLQQQlqayAMEREKVFAVLNEK 1108
Cdd:TIGR00606 1027 ENELKEVEEELKQHLKEMGQM---------QVLQMKQ-EHQKLEENIDLIKRNHVLALGRQK----GYEKEIKHFKKELR 1092

                          970       980
                   ....*....|....*....|..
gi 190194412  1109 TRENSHLKTEYHKMMDIVAAKE 1130
Cdd:TIGR00606 1093 EPQFRDAEEKYREMMIVMRTTE 1114
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 284-654 4.70e-08

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 58.53  E-value: 4.70e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  284 LSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRrEQEQLNVEKRQIMEEcenlklecsklQPS 363
Cdd:PRK10929   64 LERAKQYQQVIDNFPKLSAELRQQLNNERDEPRSVPPNMSTDALEQEILQ-VSSQLLEKSRQAQQE-----------QDR 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  364 AVKQSDTMTEkeriLAQSASveEVFRlqqALSDAENEIMRLSSLNqdNSLAEDNLKLkmrievLEKEKSLLSQEKEELQM 443
Cdd:PRK10929  132 AREISDSLSQ----LPQQQT--EARR---QLNEIERRLQTLGTPN--TPLAQAQLTA------LQAESAALKALVDELEL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  444 SLLKLNNEYEVIKSTA----TRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAE--------IEELDRQNQE----- 506
Cdd:PRK10929  195 AQLSANNRQELARLRSelakKRSQQLDAYLQALRNQLNSQRQREAERALESTELLAEqsgdlpksIVAQFKINRElsqal 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  507 --ATKHMilikDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKM-------DITKELDVQKEKLIQSEVAlnDLHLT 577
Cdd:PRK10929  275 nqQAQRM----DLIASQQRQAASQTLQVRQALNTLREQSQWLGVSNAlgealraQVARLPEMPKPQQLDTEMA--QLRVQ 348

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  578 KQKLEDkvenlvdQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQD-------------SNSNFKDTLL 644
Cdd:PRK10929  349 RLRYED-------LLNKQPQLRQIRQADGQPLTAEQNRILDAQLRTQRELLNSLLSGgdtlileltklkvANSQLEDALK 421

                         410
                  ....*....|
gi 190194412  645 KEREAEVRNL 654
Cdd:PRK10929  422 EVNEATHRYL 431
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 494-1417 5.04e-08

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 58.54  E-value: 5.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   494 IAEIEELDRQNQEATKHMilikDQLSKQQNEGDSIISKLKQdlndekkRVHQLEDDKMDITKELDVQKEKliqSEVALND 573
Cdd:TIGR02169  162 IAGVAEFDRKKEKALEEL----EEVEENIERLDLIIDEKRQ-------QLERLRREREKAERYQALLKEK---REYEGYE 227

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   574 LHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIrNELMQSLNQDSNSNFKDTLLkEREAEVRN 653
Cdd:TIGR02169  228 LLKEKEALERQKEAIERQLASLEEELEKLTEEISELEKRLEEIEQLLEEL-NKKIKDLGEEEQLRVKEKIG-ELEAEIAS 305

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   654 LKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLE---KNTIVETLKMEKGEIEAELcwakK 730
Cdd:TIGR02169  306 LERSIAEKERELEDAEERLAKLEAEIDKLLAEIEELEREIEEERKRRDKLTEEyaeLKEELEDLRAELEEVDKEF----A 381

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   731 RLLEEANKYEKTIEELSNARNlntsALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLI 810
Cdd:TIGR02169  382 ETRDELKDYREKLEKLKREIN----ELKRELDRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWKL 457

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   811 NKKEIFIEKLKERSSKLQEELDKYSQALRKNEilRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDS 890
Cdd:TIGR02169  458 EQLAADLSKYEQELYDLKEEYDRVEKELSKLQ--RELAEAEAQARASEERVRGGRAVEEVLKASIQGVHGTVAQLGSVGE 535

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   891 VTELASEVS---QLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLqSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKS 967
Cdd:TIGR02169  536 RYATAIEVAagnRLNNVVVEDDAVAKEAIELLKRRKAGRATFL-PLNKMRDERRDLSILSEDGVIGFAVDLVEFDPKYEP 614

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   968 ----------LQKTIEQIKTQLHEERqdIQTDNSDIFQETKVQ---SLNIENGSEKHDLSKAETERLVKGIKERELEIKL 1034
Cdd:TIGR02169  615 afkyvfgdtlVVEDIEAARRLMGKYR--MVTLEGELFEKSGAMtggSRAPRGGILFSRSEPAELQRLRERLEGLKRELSS 692

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1035 LNEKNISLTKQIDQLSkDEVGKLTQIIQQKDLEIQALharisstshtqdvvylQQQLQAYAMEREKVFAVLNEKTRENSH 1114
Cdd:TIGR02169  693 LQSELRRIENRLDELS-QELSDASRKIGEIEKEIEQL----------------EQEEEKLKERLEELEEDLSSLEQEIEN 755

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1115 LKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLqtsstgn 1194
Cdd:TIGR02169  756 VKSELKELEARIEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREIEQKLNRLTLEK------- 828

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1195 eaggvnsnqfEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSY 1274
Cdd:TIGR02169  829 ----------EYLEKEIQELQEQRIDLKEQIKSIEKEIENLNGKKEELEEELEELEAALRDLESRLGDLKKERDELEAQL 898

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1275 EQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSAslltpqsaeclrasksevlsessellqqeleelrK 1354
Cdd:TIGR02169  899 RELERKIEELEAQIEKKRKRLSELKAKLEALEEELSEIEDPKGED----------------------------------E 944

                          890       900       910       920       930       940
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 190194412  1355 SLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIK 1417
Cdd:TIGR02169  945 EIPEEELSLEDVQAELQRVEEEIRALEPVNMLAIQEYEEVLKRLDELKEKRAKLEEERKAILE 1007
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 1127-1771 1.49e-07

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 56.99  E-value: 1.49e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1127 AAKEAALIKLQDENKKLSTRFESsgQDMFRETIQNLSRIIREKDIEIDAL---SQKCQTLLAVLQTS--STGNEAGGVNS 1201
Cdd:TIGR02168  225 LELALLVLRLEELREELEELQEE--LKEAEEELEELTAELQELEEKLEELrleVSELEEEIEELQKElyALANEISRLEQ 302

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1202 nQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKL 1281
Cdd:TIGR02168  303 -QKQILRERLANLERQLEELEAQLEELESKLDELAEELAELEEKLEELKEELESLEAELEELEAELEELESRLEELEEQL 381

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1282 KNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASlltpQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDA 1361
Cdd:TIGR02168  382 ETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQ----QEIEELLKKLEEAELKELQAELEELEEELEELQEELE 457

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1362 TIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSD-----QLLSSNENFTNK--- 1433
Cdd:TIGR02168  458 RLEEALEELREELEEAEQALDAAERELAQLQARLDSLERLQENLEGFSEGVKALLKNQSGlsgilGVLSELISVDEGyea 537

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1434 --------------VNENELLRQAVTNLKE----RILILEMDI---GKLKGENEKIVETYRGKETEYQALQETNMKFSMM 1492
Cdd:TIGR02168  538 aieaalggrlqavvVENLNAAKKAIAFLKQnelgRVTFLPLDSikgTEIQGNDREILKNIEGFLGVAKDLVKFDPKLRKA 617

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1493 LREKEFECHSMKEKALAFEQLLKEKEQG----KTGEL---------------NQLL---NAVKSMQEKTVVFQQERDQVM 1550
Cdd:TIGR02168  618 LSYLLGGVLVVDDLDNALELAKKLRPGYrivtLDGDLvrpggvitggsaktnSSILerrREIEELEEKIEELEEKIAELE 697

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1551 LALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEdsytREALAAEDREAKLRKKVTVLEEKLVSSSNAMENA 1630
Cdd:TIGR02168  698 KALAELRKELEELEEELEQLRKELEELSRQISALRKDLARLE----AEVEQLEERIAQLSKELTELEAEIEELEERLEEA 773

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1631 S---HQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQeEKAMYSAELEKQKQLIAEWKK 1707
Cdd:TIGR02168  774 EeelAEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLER-RIAATERRLEDLEEQIEELSE 852

                          650       660       670       680       690       700
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 190194412  1708 NAENLEGKVISLQECLDEANAALDSasrLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSL 1771
Cdd:TIGR02168  853 DIESLAAEIEELEELIEELESELEA---LLNERASLEEALALLRSELEELSEELRELESKRSEL 913
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 1353-1681 1.68e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.67  E-value: 1.68e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1353 RKSLQEKDATIRTLQENNHRLSDSIAATSELERKEhEQTDSEIKQLKEKQDV----LQKLLKEKDLLIKAKSdQLLSSNE 1428
Cdd:pfam15921  478 RKVVEELTAKKMTLESSERTVSDLTASLQEKERAI-EATNAEITKLRSRVDLklqeLQHLKNEGDHLRNVQT-ECEALKL 555

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1429 NFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSMMLREKE-----FECHSM 1503
Cdd:pfam15921  556 QMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEFKILKDKKDAKIRELEarvsdLELEKV 635

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1504 KEKALAFEQLLKEKEQGKtgELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMEntaLQNEVQRLRDKEFRSNQELER 1583
Cdd:pfam15921  636 KLVNAGSERLRAVKDIKQ--ERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEE---METTTNKLKMQLKSAQSELEQ 710

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1584 LRNHL--LESEDSYT-REALAAEDREAKLRKKVTVLEEKLVSSSNAMENAS---HQASVQVESLQEQLNVVSKQRDETAL 1657
Cdd:pfam15921  711 TRNTLksMEGSDGHAmKVAMGMQKQITAKRGQIDALQSKIQFLEEAMTNANkekHFLKEEKNKLSQELSTVATEKNKMAG 790

                          330       340
                   ....*....|....*....|....
gi 190194412  1658 QLSVSQEQVKQYALSLANLQMVLE 1681
Cdd:pfam15921  791 ELEVLRSQERRLKEKVANMEVALD 814
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 641-1315 1.94e-07

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 56.67  E-value: 1.94e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   641 DTLLKEREAEVRNLKQNLSELEQLNE-----------NLKKVAFDVKMENEKLV-------LACEDVRHQLEECLagnNQ 702
Cdd:pfam15921   77 ERVLEEYSHQVKDLQRRLNESNELHEkqkfylrqsviDLQTKLQEMQMERDAMAdirrresQSQEDLRNQLQNTV---HE 153

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   703 LSLEKNTIVETLKMEKGEIEA--ELCWAKKRLLEEANKYEKTIEELSNAR-----NLNTSALQLEHEHLIKLNQKKDMEI 775
Cdd:pfam15921  154 LEAAKCLKEDMLEDSNTQIEQlrKMMLSHEGVLQEIRSILVDFEEASGKKiyehdSMSTMHFRSLGSAISKILRELDTEI 233

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   776 AELKKNI----EQMDTDHKETKDVLSSSLEE-QKQLTQLINKKEIFIEKLKERSSKLQEELDKYS--------QALRKNE 842
Cdd:pfam15921  234 SYLKGRIfpveDQLEALKSESQNKIELLLQQhQDRIEQLISEHEVEITGLTEKASSARSQANSIQsqleiiqeQARNQNS 313

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   843 ILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKtldsVTELASEVSQLNTIKEHLEEEIkhhQKIIEDQ 922
Cdd:pfam15921  314 MYMRQLSDLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSE----LTEARTERDQFSQESGNLDDQL---QKLLADL 386

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   923 NQSKMQLLQSLQEQKKEMDefRYQHEQMNATHTQLFL-EKDEEIKSLQKTIEQIKT----QLHEERQDIQTDNSDIfqeT 997
Cdd:pfam15921  387 HKREKELSLEKEQNKRLWD--RDTGNSITIDHLRRELdDRNMEVQRLEALLKAMKSecqgQMERQMAAIQGKNESL---E 461

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   998 KVQSLNIENGSEKHDLSKAETERLVKGIKERELEiKLLNEKNISLTKQiDQLSKDEVGKLTQIIQQKDLEIQALHARISS 1077
Cdd:pfam15921  462 KVSSLTAQLESTKEMLRKVVEELTAKKMTLESSE-RTVSDLTASLQEK-ERAIEATNAEITKLRSRVDLKLQELQHLKNE 539

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1078 TSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIK--------------LQDENKKL 1143
Cdd:pfam15921  540 GDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKeindrrlelqefkiLKDKKDAK 619

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1144 STRFESSGQDMFRETIQNLS------RIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVN-SNQFEELLQERDKLKQ 1216
Cdd:pfam15921  620 IRELEARVSDLELEKVKLVNagserlRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNfRNKSEEMETTTNKLKM 699

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1217 QVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTgLIQSYEQNETKLKNF-GQELAQVQHSI 1295
Cdd:pfam15921  700 QLKSAQSELEQTRNTLKSMEGSDGHAMKVAMGMQKQITAKRGQIDALQSKIQ-FLEEAMTNANKEKHFlKEEKNKLSQEL 778

                          730       740
                   ....*....|....*....|
gi 190194412  1296 GQLCNTKDLLLGKLDIISPQ 1315
Cdd:pfam15921  779 STVATEKNKMAGELEVLRSQ 798
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 425-1229 2.19e-07

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 56.52  E-value: 2.19e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   425 EVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQN 504
Cdd:pfam02463  166 RLKRKKKEALKKLIEETENLAELIIDLEELKLQELKLKEQAKKALEYYQLKEKLELEEEYLLYLDYLKLNEERIDLLQEL 245

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   505 QEATKHMILIKDQLSKQQNEgdsiISKLKQDLNDEKKRVHQLEDDKMD-ITKELDVQKEKLIQSEVALNDLHLTKQKLED 583
Cdd:pfam02463  246 LRDEQEEIESSKQEIEKEEE----KLAQVLKENKEEEKEKKLQEEELKlLAKEEEELKSELLKLERRKVDDEEKLKESEK 321

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   584 KVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQ 663
Cdd:pfam02463  322 EKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEEELEKLQEKLEQLEEELLAKKKLESERLSSAAKLKEEELELKS 401

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   664 LNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTI 743
Cdd:pfam02463  402 EEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEKQELKLLKDELELKKSEDLLKETQLVK 481

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   744 EELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELK--KNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLK 821
Cdd:pfam02463  482 LQEQLELLLSRQKLEERSQKESKARSGLKVLLALIKdgVGGRIISAHGRLGDLGVAVENYKVAISTAVIVEVSATADEVE 561

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   822 ERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEV--- 898
Cdd:pfam02463  562 ERQKLVRALTELPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKATLEADEDDKRAKVVEGILKDTELTKLKesa 641

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   899 ----SQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQ 974
Cdd:pfam02463  642 kakeSGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKEEILRRQLEIKKKEQREKEELKKLKLEAEE 721

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   975 IKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEV 1054
Cdd:pfam02463  722 LLADRVQEAQDKINEELKLLKQKIDEEEEEEEKSRLKKEEKEEEKSELSLKEKELAEEREKTEKLKVEEEKEEKLKAQEE 801

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1055 GKLTQIIQQKDLEI----------QALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKM-- 1122
Cdd:pfam02463  802 ELRALEEELKEEAElleeeqllieQEEKIKEEELEELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELee 881

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1123 MDIVAAKEAALIKLQDENKKLSTRFESSGQDMFREtIQNLSRIIREKDIEIDALSQKcqtllavlqTSSTGNEAGGVNSN 1202
Cdd:pfam02463  882 QKLKDELESKEEKEKEEKKELEEESQKLNLLEEKE-NEIEERIKEEAEILLKYEEEP---------EELLLEEADEKEKE 951

                          810       820
                   ....*....|....*....|....*..
gi 190194412  1203 QFEELLQERDKLKQQVKKMEEWKQQVM 1229
Cdd:pfam02463  952 ENNKEEEEERNKRLLLAKEELGKVNLM 978
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 201-831 2.33e-07

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 56.18  E-value: 2.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   201 QGTDNSDQSEICKLQNIIKELKQNRSQEIDdhqhemsvlqnahqqklteisrrhreELSDYEERIEELENllqqggsgvi 280
Cdd:TIGR04523   60 DKNLNKDEEKINNSNNKIKILEQQIKDLND--------------------------KLKKNKDKINKLNS---------- 103

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   281 etDLSKIYEMQKT-IQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILrreqEQLNVEKRQIMEECENLKLECSK 359
Cdd:TIGR04523  104 --DLSKINSEIKNdKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKEL----EKLNNKYNDLKKQKEELENELNL 177

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   360 LqpsavkqSDTMTEKERILAQSASveEVFRLQQALSDAENEImrlsslnqdnslaEDNLKLKMRIEVLEKEKSLLSQEKE 439
Cdd:TIGR04523  178 L-------EKEKLNIQKNIDKIKN--KLLKLELLLSNLKKKI-------------QKNKSLESQISELKKQNNQLKDNIE 235

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   440 ELQMSLLKLNNEyevIKSTATRDISLDSELHDLRLNLEAKEQELNQS---ISEKETLIAEI--EELDRQNQEATKHMILI 514
Cdd:TIGR04523  236 KKQQEINEKTTE---ISNTQTQLNQLKDEQNKIKKQLSEKQKELEQNnkkIKELEKQLNQLksEISDLNNQKEQDWNKEL 312

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   515 KDQLSKQQN----------EGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDK 584
Cdd:TIGR04523  313 KSELKNQEKkleeiqnqisQNNKIISQLNEQISQLKKELTNSESENSEKQRELEEKQNEIEKLKKENQSYKQEIKNLESQ 392

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   585 VENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLL----KEREAEVRNLKQNLSE 660
Cdd:TIGR04523  393 INDLESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDSVKeliiKNLDNTRESLETQLKV 472

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   661 LEQLNENLKKVAFDVKME---NEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAKKRLLE-EA 736
Cdd:TIGR04523  473 LSRSINKIKQNLEQKQKElksKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKESKISDLEDELNKdDF 552

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   737 NKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMdTDHKETKDVLSSSLEEQKQLTQLINKK-EI 815
Cdd:TIGR04523  553 ELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDL-IKEIEEKEKKISSLEKELEKAKKENEKlSS 631

                          650
                   ....*....|....*.
gi 190194412   816 FIEKLKERSSKLQEEL 831
Cdd:TIGR04523  632 IIKNIKSKKNKLKQEV 647
PTZ00121 PTZ00121
MAEBL; Provisional
 644-1135 2.35e-07

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 56.30  E-value: 2.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  644 LKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVR--HQLEECLAGNNQLSLEKNTIVETLKMEKGEI 721
Cdd:PTZ00121 1359 AEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKADEAKKKAEEDKKkaDELKKAAAAKKKADEAKKKAEEKKKADEAKK 1438

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  722 EAElcwaKKRLLEEAnkyEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMdtdhKETKDVLSSSLE 801
Cdd:PTZ00121 1439 KAE----EAKKADEA---KKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEA----KKKADEAKKAAE 1507

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  802 EQKQLTQLINKKEIF-IEKLKERSSKLQEELDKYSQALRKNEILRQTiEEKDRSLGSMKEENNHLQEELERLREEQSRTA 880
Cdd:PTZ00121 1508 AKKKADEAKKAEEAKkADEAKKAEEAKKADEAKKAEEKKKADELKKA-EELKKAEEKKKAEEAKKAEEDKNMALRKAEEA 1586

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  881 PVADPKTLDSVTELASEVSQLNT--IKEHLEEEIKHHQ-KIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQL 957
Cdd:PTZ00121 1587 KKAEEARIEEVMKLYEEEKKMKAeeAKKAEEAKIKAEElKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEE 1666

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  958 FLEKDEEikslQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKERELEIKLLNE 1037
Cdd:PTZ00121 1667 AKKAEED----KKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEED 1742

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1038 KNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENShLKT 1117
Cdd:PTZ00121 1743 KKKAEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGN-LVI 1821

                         490
                  ....*....|....*...
gi 190194412 1118 EYHKMMDIVAAKEAALIK 1135
Cdd:PTZ00121 1822 NDSKEMEDSAIKEVADSK 1839
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 286-509 3.48e-07

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 54.77  E-value: 3.48e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  286 KIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAV 365
Cdd:COG4942    35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELAELLRALY 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  366 KQSDtmTEKERILAQSASVEEVFRLQQALSDAeneimrlssLNQDNSLAEDnlkLKMRIEVLEKEKSLLSQEKEELQMSL 445
Cdd:COG4942   115 RLGR--QPPLALLLSPEDFLDAVRRLQYLKYL---------APARREQAEE---LRADLAELAALRAELEAERAELEALL 180

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 190194412  446 LKLNNEYEVIKSTATRdisLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATK 509
Cdd:COG4942   181 AELEEERAALEALKAE---RQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAE 241
PRK01156 PRK01156
chromosome segregation protein; Provisional
 307-850 3.49e-07

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 55.68  E-value: 3.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  307 KMEQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQpsavKQSDTMTEKErilaqsasvEE 386
Cdd:PRK01156  191 KLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSALNELS----SLEDMKNRYE---------SE 257

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  387 VFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLE--KEKSLLSQEKEELQMSLLKLNNEYEVIKSTAtrDIS 464
Cdd:PRK01156  258 IKTAESDLSMELEKNNYYKELEERHMKIINDPVYKNRNYINDyfKYKNDIENKKQILSNIDAEINKYHAIIKKLS--VLQ 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  465 LDselHDLRLNLEAKEQELNQSISEKET-------LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLN 537
Cdd:PRK01156  336 KD---YNDYIKKKSRYDDLNNQILELEGyemdynsYLKSIESLKKKIEEYSKNIERMSAFISEILKIQEIDPDAIKKELN 412

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  538 DEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDL-----------HLTKQKLEDKVENLVDQLNKSQESNVSIQKEN 606
Cdd:PRK01156  413 EINVKLQDISSKVSSLNQRIRALRENLDELSRNMEMLngqsvcpvcgtTLGEEKSNHIINHYNEKKSRLEEKIREIEIEV 492

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  607 LELKEHIRQNEEELSRIRNELMQSLNQDSNsnfkdtLLKEREAEVRNLKQNLSELEQlnENLKKVAFDVKMENEKLvlac 686
Cdd:PRK01156  493 KDIDEKIVDLKKRKEYLESEEINKSINEYN------KIESARADLEDIKIKINELKD--KHDKYEEIKNRYKSLKL---- 560

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  687 EDVRHQLEECLAGNNQLSlekNTIVETLKMEKGEIEAELCWAKKRLLEeankyekTIEELSNARNLNTSALQLEHEHLIK 766
Cdd:PRK01156  561 EDLDSKRTSWLNALAVIS---LIDIETNRSRSNEIKKQLNDLESRLQE-------IEIGFPDDKSYIDKSIREIENEANN 630

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  767 LNQKKDmEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQ 846
Cdd:PRK01156  631 LNNKYN-EIQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDIEDNLKKSRKALDDAKANRARLESTIEILRT 709


                  ....
gi 190194412  847 TIEE 850
Cdd:PRK01156  710 RINE 713
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
389-861 5.18e-07

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 55.07  E-value: 5.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  389 RLQQALSDAENEIMRLSSLNQDNSLAEDNLK-LKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDS 467
Cdd:PRK03918  166 NLGEVIKEIKRRIERLEKFIKRTENIEELIKeKEKELEEVLREINEISSELPELREELEKLEKEVKELEELKEEIEELEK 245

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  468 ELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQE-------ATKHMILIK--DQLSKQQNEGDSIISKLKQDLND 538
Cdd:PRK03918  246 ELESLEGSKRKLEEKIRELEERIEELKKEIEELEEKVKElkelkekAEEYIKLSEfyEEYLDELREIEKRLSRLEEEING 325

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  539 EKKRVHQLEDDKMDItKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLvdQLNKSQESNVSIQKENLELKEHIRQNEE 618
Cdd:PRK03918  326 IEERIKELEEKEERL-EELKKKLKELEKRLEELEERHELYEEAKAKKEEL--ERLKKRLTGLTPEKLEKELEELEKAKEE 402

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  619 -------------ELSRIRNELMQSLNQ-------------DSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVA 672
Cdd:PRK03918  403 ieeeiskitarigELKKEIKELKKAIEElkkakgkcpvcgrELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKEL 482

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  673 FDVKME--NEKLVLACEDVRHQL---EECLAGNNQLSLEKNT-IVETLKMEKGEIEAELCWAKKRlLEEANKYEKTIEEL 746
Cdd:PRK03918  483 RELEKVlkKESELIKLKELAEQLkelEEKLKKYNLEELEKKAeEYEKLKEKLIKLKGEIKSLKKE-LEKLEELKKKLAEL 561

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  747 SNA-RNLNTSALQLEHEhlikLNQKKDMEIAELKKNIEQMDTDHKE------TKDVLSSSLEEQKQLTQLINKKEIFIEK 819
Cdd:PRK03918  562 EKKlDELEEELAELLKE----LEELGFESVEELEERLKELEPFYNEylelkdAEKELEREEKELKKLEEELDKAFEELAE 637

                         490       500       510       520
                  ....*....|....*....|....*....|....*....|....*.
gi 190194412  820 LKERSSKLQEELD----KYSQalRKNEILRQTIEEKDRSLGSMKEE 861
Cdd:PRK03918  638 TEKRLEELRKELEelekKYSE--EEYEELREEYLELSRELAGLRAE 681
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 166-1084 6.07e-07

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 55.06  E-value: 6.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   166 DIISSQQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDdhqhemsvlqnahqq 245
Cdd:TIGR01612  573 DSIHLEKEIKDLFDKYLEIDDEIIYINKLKLELKEKIKNISDKNEYIKKAIDLKKIIENNNAYID--------------- 637

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   246 kltEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIY-EMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSS 324
Cdd:TIGR01612  638 ---ELAKISPYQVPEHLKNKDKIYSTIKSELSKIYEDDIDALYnELSSIVKENAIDNTEDKAKLDDLKSKIDKEYDKIQN 714

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   325 AENdrdilrreqeqlnvekrqimeecENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEevfrLQQALSDAENEIMRL 404
Cdd:TIGR01612  715 MET-----------------------ATVELHLSNIENKKNELLDIIVEIKKHIHGEINKD----LNKILEDFKNKEKEL 767

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   405 SSLNQDNSLAEDNL-KLKMRIEVLE---KEKSLLSQEKEELQMSLLKLNNEYevikstaTRDISLdselhdlrlnleaKE 480
Cdd:TIGR01612  768 SNKINDYAKEKDELnKYKSKISEIKnhyNDQINIDNIKDEDAKQNYDKSKEY-------IKTISI-------------KE 827

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   481 QELNQSISEKETLIAEI-EELDRQNQEATKHmiliKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLE-DDKMDITKELD 558
Cdd:TIGR01612  828 DEIFKIINEMKFMKDDFlNKVDKFINFENNC----KEKIDSEHEQFAELTNKIKAEISDDKLNDYEKKfNDSKSLINEIN 903

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   559 VQKEKLIQSEVALNDLH-------LTKQKLEdKVENLVDQLNKSQESNVSIQKE-NLELKEHIRQNEEELSRIRNELMQS 630
Cdd:TIGR01612  904 KSIEEEYQNINTLKKVDeyikiceNTKESIE-KFHNKQNILKEILNKNIDTIKEsNLIEKSYKDKFDNTLIDKINELDKA 982

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   631 lnqdsnsnFKDTLLKEREAEVRNLKQNLSEL-EQLNENLKKVAFDVKMENEKlvlACEDVRHQLEECLAGNNQLSLEKNT 709
Cdd:TIGR01612  983 --------FKDASLNDYEAKNNELIKYFNDLkANLGKNKENMLYHQFDEKEK---ATNDIEQKIEDANKNIPNIEIAIHT 1051

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   710 IVETLKME-KGEIEAELCWAKKRLLEEANkyektieelSNARNLNTSALQLEHEHLIKL----NQKKDMEIAELKKNIEQ 784
Cdd:TIGR01612 1052 SIYNIIDEiEKEIGKNIELLNKEILEEAE---------INITNFNEIKEKLKHYNFDDFgkeeNIKYADEINKIKDDIKN 1122

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   785 MdtDHKETKDVlsssleeqKQLTQLINKKEIFIEKLKERSSKLQEELDK--YSQALRKNEILRQTIEEKDRSLGSMKEEN 862
Cdd:TIGR01612 1123 L--DQKIDHHI--------KALEEIKKKSENYIDEIKAQINDLEDVADKaiSNDDPEEIEKKIENIVTKIDKKKNIYDEI 1192

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   863 NHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIED------QNQSKMQLLQSLQEQ 936
Cdd:TIGR01612 1193 KKLLNEIAEIEKDKTSLEEVKGINLSYGKNLGKLFLEKIDEEKKKSEHMIKAMEAYIEDldeikeKSPEIENEMGIEMDI 1272

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   937 KKEMDEFRYQHEQMNATHTqLFLEKDEEI-----KSLQKT--------IEQIKTQLHEERQDIQTDNSDIFQETKvQSLN 1003
Cdd:TIGR01612 1273 KAEMETFNISHDDDKDHHI-ISKKHDENIsdireKSLKIIedfseesdINDIKKELQKNLLDAQKHNSDINLYLN-EIAN 1350

                          890       900       910       920       930       940       950       960
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1004 IENgsekhDLSKAETERLVKGIKERELEIKLLNeKNISltkqiDQLSKDEvgKLTQIIQQkDLEIQALHARISSTSHTQD 1083
Cdd:TIGR01612 1351 IYN-----ILKLNKIKKIIDEVKEYTKEIEENN-KNIK-----DELDKSE--KLIKKIKD-DINLEECKSKIESTLDDKD 1416


                   .
gi 190194412  1084 V 1084
Cdd:TIGR01612 1417 I 1417
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1503-1765 1.43e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.40  E-value: 1.43e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1503 MKEKALAFEQLLKEKEQgKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELE 1582
Cdd:COG1196   248 LEELEAELEELEAELAE-LEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEELA 326

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1583 RLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVS 1662
Cdd:COG1196   327 ELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELE 406

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1663 QEQVKQYALSLANLQMVLEHFQQEEKAmySAELEKQKQLIAEWKKNAENLEGKVISLQECLDEanaALDSASRLTEQLDV 1742
Cdd:COG1196   407 EAEEALLERLERLEEELEELEEALAEL--EEEEEEEEEALEEAAEEEAELEEEEEALLELLAE---LLEEAALLEAALAE 481

                         250       260
                  ....*....|....*....|...
gi 190194412 1743 KEEQIEELKRQNELRQEMLDDVQ 1765
Cdd:COG1196   482 LLEELAEAAARLLLLLEAEADYE 504
Mplasa_alph_rch TIGR04523
helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of ...
 505-1145 1.96e-06

helix-rich Mycoplasma protein; Members of this family occur strictly within a subset of Mycoplasma species. Members average 750 amino acids in length, including signal peptide. Sequences are predicted (Jpred 3) to be almost entirely alpha-helical. These sequences show strong periodicity (consistent with long alpha helical structures) and low complexity rich in D,E,N,Q, and K. Genes encoding these proteins are often found in tandem. The function is unknown.


Pssm-ID: 275316 [Multi-domain]  Cd Length: 745  Bit Score: 53.10  E-value: 1.96e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   505 QEATKHMILIKDQLSKQQNEgdsiISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDK 584
Cdd:TIGR04523   36 KQLEKKLKTIKNELKNKEKE----LKNLDKNLNKDEEKINNSNNKIKILEQQIKDLNDKLKKNKDKINKLNSDLSKINSE 111

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   585 VENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFK----DTLLKEREAEVRNLKQNLSE 660
Cdd:TIGR04523  112 IKNDKEQKNKLEVELNKLEKQKKENKKNIDKFLTEIKKKEKELEKLNNKYNDLKKQkeelENELNLLEKEKLNIQKNIDK 191

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   661 LEQLNENLKKVAFDVKMENEKLVLacedVRHQLEECLAGNNQLslekNTIVETLKMEKGEIEAELCWAKKRLLEEANKYE 740
Cdd:TIGR04523  192 IKNKLLKLELLLSNLKKKIQKNKS----LESQISELKKQNNQL----KDNIEKKQQEINEKTTEISNTQTQLNQLKDEQN 263

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   741 KTIEELSNARNLNTSALQLEHEHLIKLNQKKdMEIAELKKNIEQmdTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKL 820
Cdd:TIGR04523  264 KIKKQLSEKQKELEQNNKKIKELEKQLNQLK-SEISDLNNQKEQ--DWNKELKSELKNQEKKLEEIQNQISQNNKIISQL 340

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   821 KERSSKLQEELDKYSQalrKNEILRQTIEEKDRSLGSMKEENNhlqeelerlreeqsrtapvadpKTLDSVTELASEVSQ 900
Cdd:TIGR04523  341 NEQISQLKKELTNSES---ENSEKQRELEEKQNEIEKLKKENQ----------------------SYKQEIKNLESQIND 395

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   901 LNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTqlflEKDEEIKSLQKTIEQIKTQLH 980
Cdd:TIGR04523  396 LESKIQNQEKLNQQKDEQIKKLQQEKELLEKEIERLKETIIKNNSEIKDLTNQDS----VKELIIKNLDNTRESLETQLK 471

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   981 EERQDIQTDNSDIFQETKvqslNIENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKdEVGKLTQI 1060
Cdd:TIGR04523  472 VLSRSINKIKQNLEQKQK----ELKSKEKELKKLNEEKKELEEKVKDLTKKISSLKEKIEKLESEKKEKES-KISDLEDE 546

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1061 IQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDEN 1140
Cdd:TIGR04523  547 LNKDDFELKKENLEKEIDEKNKEIEELKQTQKSLKKKQEEKQELIDQKEKEKKDLIKEIEEKEKKISSLEKELEKAKKEN 626


                   ....*
gi 190194412  1141 KKLST 1145
Cdd:TIGR04523  627 EKLSS 631
PTZ00121 PTZ00121
MAEBL; Provisional
 240-1056 2.95e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 52.84  E-value: 2.95e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  240 QNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVietDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIK-DI 318
Cdd:PTZ00121 1146 RKAEDAKRVEIARKAEDARKAEEARKAEDAKKAEAARKAE---EVRKAEELRKAEDARKAEAARKAEEERKAEEARKaED 1222

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  319 NKKLSSAENDRDILRREQEQLNVEKRQIMEECEnlKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQAlsDAE 398
Cdd:PTZ00121 1223 AKKAEAVKKAEEAKKDAEEAKKAEEERNNEEIR--KFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEA--KKA 1298

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  399 NEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQmsllklnNEYEVIKSTAtrdisldselhdlrlnlEA 478
Cdd:PTZ00121 1299 EEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAK-------KAAEAAKAEA-----------------EA 1354

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  479 KEQELNQSISEKETLIAEIEELDRQNQEATKHMILIK--DQLSKQQNEGDSIISKLKQDlNDEKKRVHQLEDDKMDITKE 556
Cdd:PTZ00121 1355 AADEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKkaDEAKKKAEEDKKKADELKKA-AAAKKKADEAKKKAEEKKKA 1433

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  557 LDVQKEKliqSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQK-ENLELKEHIRQNEEELSRIRNELMQSLNQDS 635
Cdd:PTZ00121 1434 DEAKKKA---EEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKaEEAKKADEAKKKAEEAKKKADEAKKAAEAKK 1510

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  636 NSN-FKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEklVLACEDVRhQLEECLAGNNQLSLEKNTIVETL 714
Cdd:PTZ00121 1511 KADeAKKAEEAKKADEAKKAEEAKKADEAKKAEEKKKADELKKAEE--LKKAEEKK-KAEEAKKAEEDKNMALRKAEEAK 1587

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  715 KMEKGEIEAELCW---AKKRLLEEANKYEKT---IEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTD 788
Cdd:PTZ00121 1588 KAEEARIEEVMKLyeeEKKMKAEEAKKAEEAkikAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKIKAAEEA 1667

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  789 HKETKDvlSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEE 868
Cdd:PTZ00121 1668 KKAEED--KKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKAEEENKIKAEEAKKEAEEDKKK 1745

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  869 LERLREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHE 948
Cdd:PTZ00121 1746 AEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKIKDIFDNFANIIEGGKEGNLVINDSK 1825

                         730       740       750       760       770       780       790       800
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  949 QMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHdlskaETERLVKGIKER 1028
Cdd:PTZ00121 1826 EMEDSAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEAD-----EIEKIDKDDIER 1900

                         810       820
                  ....*....|....*....|....*...
gi 190194412 1029 ELEIKLLNEKNISLTKqiDQLSKDEVGK 1056
Cdd:PTZ00121 1901 EIPNNNMAGKNNDIID--DKLDKDEYIK 1926
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 611-1285 9.85e-06

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 50.71  E-value: 9.85e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  611 EHIRQNEEELSRIRNELMQSLnqdsnsnfkDTLlkEREAEV----RNLKQNLSELEQlnenlkkvafdvkmenEKLVLAC 686
Cdd:COG1196   182 EATEENLERLEDILGELERQL---------EPL--ERQAEKaeryRELKEELKELEA----------------ELLLLKL 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  687 EDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAelcwAKKRLLEEANKYEKTIEELSNARNlNTSALQLEHEHLIK 766
Cdd:COG1196   235 RELEAELEELEAELEELEAELEELEAELAELEAELEE----LRLELEELELELEEAQAEEYELLA-ELARLEQDIARLEE 309

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  767 LNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDkysqalrknEILRQ 846
Cdd:COG1196   310 RRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELA---------EAEEE 380

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  847 TIEEKDRSLGSMKEENNHLQEELERLREEQSRtapvadpktLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSK 926
Cdd:COG1196   381 LEELAEELLEALRAAAELAAQLEELEEAEEAL---------LERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEE 451

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  927 MQLLQSLQEQKKEMDEFRYQHEQMNATHTQLfLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIEN 1006
Cdd:COG1196   452 AELEEEEEALLELLAELLEEAALLEAALAEL-LEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLI 530

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1007 GSEKHDLSKAETERLVkgikereLEIKLLNEKNISLTKQIDQLSKDEVGKLTQIIQQKDLEIQALHARISSTSHTQDVVY 1086
Cdd:COG1196   531 GVEAAYEAALEAALAA-------ALQNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDL 603

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1087 LQQQLQAYAMEREKVFAVLNEKTRENSHLKTeyhkmmdivAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRII 1166
Cdd:COG1196   604 VASDLREADARYYVLGDTLLGRTLVAARLEA---------ALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAAL 674

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1167 REKDIEIDALSQKCQTLLAVLQTsstgneaggvnsnQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEEL 1246
Cdd:COG1196   675 LEAEAELEELAERLAEEELELEE-------------ALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEEL 741

                         650       660       670
                  ....*....|....*....|....*....|....*....
gi 190194412 1247 HQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFG 1285
Cdd:COG1196   742 LEEEELLEEEALEELPEPPDLEELERELERLEREIEALG 780
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 1543-1778 9.92e-06

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 50.15  E-value: 9.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1543 QQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESE---DSYTREALAAEDREAKLRKKVTVLEEK 1619
Cdd:COG4942    19 ADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALArriRALEQELAALEAELAELEKEIAELRAE 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1620 LVSssnamenashqasvQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYS--AELEK 1697
Cdd:COG4942    99 LEA--------------QKEELAELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRAdlAELAA 164

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1698 QKQLIAEWKKNAENLEGKVISLQECLDEANAALDSA-SRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSLANSSE 1776
Cdd:COG4942   165 LRAELEAERAELEALLAELEEERAALEALKAERQKLlARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTP 244


                  ..
gi 190194412 1777 GK 1778
Cdd:COG4942   245 AA 246
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
1363-1771 1.14e-05

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 50.45  E-value: 1.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1363 IRTLQENNHRLSDSIAATSELERKEHEQTDS---EIKQLKEKQDVLQKLLKEKDLLIKAKSDqLLSSNENFTNKVNENEL 1439
Cdd:PRK03918  171 IKEIKRRIERLEKFIKRTENIEELIKEKEKEleeVLREINEISSELPELREELEKLEKEVKE-LEELKEEIEELEKELES 249

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1440 LRQAVTNLKERILILEMDIGKLKG------ENEKIVETYRGKETEYQALQETNMKFSMMLREKEFECHSMKEKALAFEQL 1513
Cdd:PRK03918  250 LEGSKRKLEEKIRELEERIEELKKeieeleEKVKELKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEER 329

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1514 LKEKEQgKTGELNQLLNAVKSMQEKTVVFQqERDQVMLALKQKQMENTALQNEVQRLR-DKEFRSNQELERLRNHLLESE 1592
Cdd:PRK03918  330 IKELEE-KEERLEELKKKLKELEKRLEELE-ERHELYEEAKAKKEELERLKKRLTGLTpEKLEKELEELEKAKEEIEEEI 407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1593 DSYTREALAAEDREAKLRKKVTVLEE-KLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYAL 1671
Cdd:PRK03918  408 SKITARIGELKKEIKELKKAIEELKKaKGKCPVCGRELTEEHRKELLEEYTAELKRIEKELKEIEEKERKLRKELRELEK 487

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1672 SLANLQMV---------LEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEANAALDSASRLTEQLDV 1742
Cdd:PRK03918  488 VLKKESELiklkelaeqLKELEEKLKKYNLEELEKKAEEYEKLKEKLIKLKGEIKSLKKELEKLEELKKKLAELEKKLDE 567

                         410       420       430
                  ....*....|....*....|....*....|
gi 190194412 1743 KEEQIEELKRQ-NELRQEMLDDVQKKLMSL 1771
Cdd:PRK03918  568 LEEELAELLKElEELGFESVEELEERLKEL 597
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
171-545 1.29e-05

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 50.15  E-value: 1.29e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  171 QQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRsQEIDDHQHEMSVLQNAHQQKLTEI 250
Cdd:COG4717   108 EAELEELREELEKLEKLLQLLPLYQELEALEAELAELPERLEELEERLEELRELE-EELEELEAELAELQEELEELLEQL 186

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  251 SRRHREELSDYEERIEELENLLQQggsgvIETDLSKIYEMQKTIQVlQIEKVESTKKMEQLEDKIKD------------- 317
Cdd:COG4717   187 SLATEEELQDLAEELEELQQRLAE-----LEEELEEAQEELEELEE-ELEQLENELEAAALEERLKEarlllliaaalla 260

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  318 --------------------------------INKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLecsklqpsav 365
Cdd:COG4717   261 llglggsllsliltiagvlflvlgllallfllLAREKASLGKEAEELQALPALEELEEEELEELLAALGL---------- 330

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  366 kqsDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQDNSL-----AEDNLKLKMRIEVLEKEKSLLsQEKEE 440
Cdd:COG4717   331 ---PPDLSPEELLELLDRIEELQELLREAEELEEELQLEELEQEIAALlaeagVEDEEELRAALEQAEEYQELK-EELEE 406

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  441 LQMSLLKLNNEYEVIKSTATRDiSLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQ-EATKHMILIKDQLS 519
Cdd:COG4717   407 LEEQLEELLGELEELLEALDEE-ELEEELEELEEELEELEEELEELREELAELEAELEQLEEDGElAELLQELEELKAEL 485

                         410       420
                  ....*....|....*....|....*.
gi 190194412  520 KQQNEGDSIISKLKQDLNDEKKRVHQ 545
Cdd:COG4717   486 RELAEEWAALKLALELLEEAREEYRE 511
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 464-672 1.59e-05

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 49.38  E-value: 1.59e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  464 SLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEgdsiISKLKQDLNDEKKRV 543
Cdd:COG4942    24 EAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAE----LAELEKEIAELRAEL 99

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  544 HQLEDD---------KMDITKELDV--QKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEH 612
Cdd:COG4942   100 EAQKEElaellralyRLGRQPPLALllSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEAL 179

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 190194412  613 IRQNEEELSRI------RNELMQSLNQDsnsnfkdtlLKEREAEVRNLKQNLSELEQLNENLKKVA 672
Cdd:COG4942   180 LAELEEERAALealkaeRQKLLARLEKE---------LAELAAELAELQQEAEELEALIARLEAEA 236
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 483-1230 1.96e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 49.84  E-value: 1.96e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   483 LNQSISEKETLIAEIEELDRQNQEATKhmilikdQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDkmdITKELDVQKE 562
Cdd:pfam12128  246 LQQEFNTLESAELRLSHLHFGYKSDET-------LIASRQEERQETSAELNQLLRTLDDQWKEKRDE---LNGELSAADA 315

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   563 KLiqsevalndlhltkQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQdsnsnfkdt 642
Cdd:pfam12128  316 AV--------------AKDRSELEALEDQHGAFLDADIETAAADQEQLPSWQSELENLEERLKALTGKHQD--------- 372

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   643 llKEREAEVRNLK---QNLSELEQLNENLKKVafdvKMENEKLVLACEDVRHQLEeclagnNQLSLEKNTIVETLKMEKG 719
Cdd:pfam12128  373 --VTAKYNRRRSKikeQNNRDIAGIKDKLAKI----REARDRQLAVAEDDLQALE------SELREQLEAGKLEFNEEEY 440

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   720 EIEAELCWAKKRLleeaNKYEKTIEELSNARNlNTSALQLEHEHLIKLNQKKD---MEIAELKKNIEQMDTDHKETKDVL 796
Cdd:pfam12128  441 RLKSRLGELKLRL----NQATATPELLLQLEN-FDERIERAREEQEAANAEVErlqSELRQARKRRDQASEALRQASRRL 515

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   797 SSSLEEQKQL-TQLINKKEIFIEKLKERSSKLQEELDKysqaLRKNEILRQTIEEKDRSLGSMKEENNHLQEELerlree 875
Cdd:pfam12128  516 EERQSALDELeLQLFPQAGTLLHFLRKEAPDWEQSIGK----VISPELLHRTDLDPEVWDGSVGGELNLYGVKL------ 585

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   876 qsRTAPVADPKTLDSVTELASEVSQLntikehlEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHT 955
Cdd:pfam12128  586 --DLKRIDVPEWAASEEELRERLDKA-------EEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNARLDLR 656

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   956 QLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSLNIENGSEKHDLSKAETERLVKGIKEREL----- 1030
Cdd:pfam12128  657 RLFDEKQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLallka 736

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1031 EIKLLNEKNISLTKQIDQLSKDEVGKL---TQIIQQKDLEIQALHARISSTSHTQDVV--YLQQQLQAYAMEREKVFAVL 1105
Cdd:pfam12128  737 AIAARRSGAKAELKALETWYKRDLASLgvdPDVIAKLKREIRTLERKIERIAVRRQEVlrYFDWYQETWLQRRPRLATQL 816

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1106 NEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRfessgqdmfretiqnLSRIIREKDIEIDALSQkcqtlLA 1185
Cdd:pfam12128  817 SNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVR---------------LSENLRGLRCEMSKLAT-----LK 876

                          730       740       750       760
                   ....*....|....*....|....*....|....*....|....*
gi 190194412  1186 VLQTSSTGNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMT 1230
Cdd:pfam12128  877 EDANSEQAQGSIGERLAQLEDLKLKRDYLSESVKKYVEHFKNVIA 921
COG5022 COG5022
Myosin heavy chain [General function prediction only];
389-671 2.11e-05

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 49.69  E-value: 2.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  389 RLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLS-QEKEELQMSLLKLNNEYE-------VIKSTAT 460
Cdd:COG5022   758 RYLRRRYLQALKRIKKIQVIQHGFRLRRLVDYELKWRLFIKLQPLLSlLGSRKEYRSYLACIIKLQktikrekKLRETEE 837

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  461 RDISLDSE--LHDLRLNLEAKEQ---ELNQSISEKETliAEIEELDRQNQEaTKHMILIKDQLSKQQNEGDSIISKLKQD 535
Cdd:COG5022   838 VEFSLKAEvlIQKFGRSLKAKKRfslLKKETIYLQSA--QRVELAERQLQE-LKIDVKSISSLKLVNLELESEIIELKKS 914

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  536 LNDE--KKRVHQLEDD----KMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLEL 609
Cdd:COG5022   915 LSSDliENLEFKTELIarlkKLLNNIDLEEGPSIEYVKLPELNKLHEVESKLKETSEEYEDLLKKSTILVREGNKANSEL 994

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190194412  610 KEHIR------------QNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLS-ELEQLNENLKKV 671
Cdd:COG5022   995 KNFKKelaelskqygalQESTKQLKELPVEVAELQSASKIISSESTELSILKPLQKLKGLLLlENNQLQARYKAL 1069
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 171-802 2.22e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 49.55  E-value: 2.22e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  171 QQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEI 250
Cdd:COG1196   245 EAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEELEEE 324

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  251 SRRHREELSDYEERIEELENllqqggsgvietdlskiyemqktiqvlqiEKVESTKKMEQLEDKIKDINKKLSSAENDRD 330
Cdd:COG1196   325 LAELEEELEELEEELEELEE-----------------------------ELEEAEEELEEAEAELAEAEEALLEAEAELA 375

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  331 ILRREQEQLNVEKRQIMEECENLKlecSKLQPSAVKQSDTMTEKERILAQsasveevfRLQQALSDAENEIMRLSSLNQD 410
Cdd:COG1196   376 EAEEELEELAEELLEALRAAAELA---AQLEELEEAEEALLERLERLEEE--------LEELEEALAELEEEEEEEEEAL 444

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  411 NSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEK 490
Cdd:COG1196   445 EEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAG 524

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  491 ETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLndeKKRVHQLEDDKMDITKELDVQKEKLIQSEVA 570
Cdd:COG1196   525 AVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLKAAK---AGRATFLPLDKIRARAALAAALARGAIGAAV 601

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  571 LNDlhltkqKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQ--DSNSNFKDTLLKERE 648
Cdd:COG1196   602 DLV------ASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAggSLTGGSRRELLAALL 675

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  649 AEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCwA 728
Cdd:COG1196   676 EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEAL-E 754

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  729 KKRLLEEANKYEKTIEELSNARNL----NTSALQlEHEHLIK-----LNQKKDME--IAELKKNIEQMDtdhKETKDVLS 797
Cdd:COG1196   755 ELPEPPDLEELERELERLEREIEAlgpvNLLAIE-EYEELEErydflSEQREDLEeaRETLEEAIEEID---RETRERFL 830


                  ....*
gi 190194412  798 SSLEE 802
Cdd:COG1196   831 ETFDA 835
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 1385-1652 2.77e-05

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 49.35  E-value: 2.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1385 RKEHEQTDSEI---KQLKEKQDVLQKLLkEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERIlilEMDIGKL 1461
Cdd:pfam17380  302 RQEKEEKAREVerrRKLEEAEKARQAEM-DRQAAIYAEQERMAMERERELERIRQEERKRELERIRQEEI---AMEISRM 377

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1462 KGENEKIVETYRGKETEYQALqETNMKFSMMLREKEfecHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVV 1541
Cdd:pfam17380  378 RELERLQMERQQKNERVRQEL-EAARKVKILEEERQ---RKIQQQKVEMEQIRAEQEEARQREVRRLEEERAREMERVRL 453

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1542 FQQERDQVMLALKQKQMEntalQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKVTVLEEKLV 1621
Cdd:pfam17380  454 EEQERQQQVERLRQQEEE----RKRKKLELEKEKRDRKRAEEQRRKILEKELEERKQAMIEEERKRKLLEKEMEERQKAI 529

                          250       260       270
                   ....*....|....*....|....*....|....*.
gi 190194412  1622 SSSNAMENASHQASVQVE-----SLQEQLNVVSKQR 1652
Cdd:pfam17380  530 YEEERRREAEEERRKQQEmeerrRIQEQMRKATEER 565
235kDa-fam TIGR01612
reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in ...
 265-1034 4.37e-05

reticulocyte binding/rhoptry protein; This model represents a group of paralogous families in plasmodium species alternately annotated as reticulocyte binding protein, 235-kDa family protein and rhoptry protein. Rhoptry protein is localized on the cell surface and is extremely large (although apparently lacking in repeat structure) and is important for the process of invasion of the RBCs by the parasite. These proteins are found in P. falciparum, P. vivax and P. yoelii.


Pssm-ID: 130673 [Multi-domain]  Cd Length: 2757  Bit Score: 48.89  E-value: 4.37e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   265 IEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQ--IEKVESTKK-MEQLEDKIKDINKKLSSAENDRDILRREQEQLNV 341
Cdd:TIGR01612 1623 LKETESIEKKISSFSIDSQDTELKENGDNLNSLQefLESLKDQKKnIEDKKKELDELDSEIEKIEIDVDQHKKNYEIGII 1702

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   342 EKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMRLSSLNQD-------NSLA 414
Cdd:TIGR01612 1703 EKIKEIAIANKEEIESIKELIEPTIENLISSFNTNDLEGIDPNEKLEEYNTEIGDIYEEFIELYNIIAGcletvskEPIT 1782

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   415 EDNLK---------LKMRIEVLEKEKSLLSQ-EKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDlrlnleakeqELN 484
Cdd:TIGR01612 1783 YDEIKntrinaqneFLKIIEIEKKSKSYLDDiEAKEFDRIINHFKKKLDHVNDKFTKEYSKINEGFD----------DIS 1852

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   485 QSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSI---ISKLKQDLNDEKKR---VHQLEDDKMDITKELD 558
Cdd:TIGR01612 1853 KSIENVKNSTDENLLFDILNKTKDAYAGIIGKKYYSYKDEAEKIfinISKLANSINIQIQNnsgIDLFDNINIAILSSLD 1932

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   559 VQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQ------ESNVSIQKENLELKEHIRQNEE----------ELSR 622
Cdd:TIGR01612 1933 SEKEDTLKFIPSPEKEPEIYTKIRDSYDTLLDIFKKSQdlhkkeQDTLNIIFENQQLYEKIQASNElkdtlsdlkyKKEK 2012

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   623 IRNEL------MQSLNQDS-NSNFKDTLLKEREAEvrNLKQNLSELEQLNENLKkVAFDVKMENEKL---VLACEDVRHQ 692
Cdd:TIGR01612 2013 ILNDVklllhkFDELNKLScDSQNYDTILELSKQD--KIKEKIDNYEKEKEKFG-IDFDVKAMEEKFdndIKDIEKFENN 2089

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   693 LEECLAGNNQLSLEKNTIVETLK--------------------MEKGEIEAELCWAKKRLL------------------- 733
Cdd:TIGR01612 2090 YKHSEKDNHDFSEEKDNIIQSKKklkelteafnteikiiedkiIEKNDLIDKLIEMRKECLlfsyatlvetlkskvinhs 2169

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   734 ---EEANKYEKT----IEELSNARNLNTSALQLEH------EHLIKLNQ----------KKDMEIAELKKNIEQMDTDHK 790
Cdd:TIGR01612 2170 efiTSAAKFSKDffefIEDISDSLNDDIDALQIKYnlnqtkKHMISILAdatkdhnnliEKEKEATKIINNLTELFTIDF 2249

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   791 ETKDV----------------LSSSLEEQKQLTQ-----------LINKKEIFIEK-----LKERSSKLQEELDKYSQ-- 836
Cdd:TIGR01612 2250 NNADAdilhnnkiqiiyfnseLHKSIESIKKLYKkinafkllnisHINEKYFDISKefdniIQLQKHKLTENLNDLKEid 2329

                          730       740       750       760       770       780       790       800
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   837 ---ALRKNEILRQTIEEKDRSLGSMKE--ENNHLQEELERLREEQSRTAPVADPKTLDSVTELASEVSQL---------- 901
Cdd:TIGR01612 2330 qyiSDKKNIFLHALNENTNFNFNALKEiyDDIINRENKADEIENINNKENENIMQYIDTITKLTEKIQDIlifvttyend 2409

                          810       820       830       840       850       860       870       880
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   902 -NTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNA-------------THTQLFLEKDEEIKS 967
Cdd:TIGR01612 2410 nNIIKQHIQDNDENDVSKIKDNLKKTIQSFQEILNKIDEIKAQFYGGNNINNiiitisqnandvkNHFSKDLTIENELIQ 2489

                          890       900       910       920       930       940       950
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190194412   968 LQKTIEQIKTQLHEER--QDIQTDNSdIFQETKVQSLNIENGSEKHDLSKA-ETERLVKGIK--ERELEIKL 1034
Cdd:TIGR01612 2490 IQKRLEDIKNAAHEIRseQITKYTNA-IHNHIEEQFKKIENNSNKDEVYKInEIDNIIEKIInyNKEPEVKL 2560
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1505-1768 4.51e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.78  E-value: 4.51e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1505 EKALAFEQLlkeKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERL 1584
Cdd:COG1196   210 EKAERYREL---KEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEA 286

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1585 RNHLLEsedsytrealaAEDREAKLRKKVTVLEEKLvsssnamenashqasvqvESLQEQLNVVSKQRDETALQLSVSQE 1664
Cdd:COG1196   287 QAEEYE-----------LLAELARLEQDIARLEERR------------------RELEERLEELEEELAELEEELEELEE 337

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1665 QVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEwkknAENLEGKVISLQECLDEANAALDSASRLTEQLDVKE 1744
Cdd:COG1196   338 ELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEA----EEELEELAEELLEALRAAAELAAQLEELEEAEEALL 413

                         250       260
                  ....*....|....*....|....
gi 190194412 1745 EQIEELKRQNELRQEMLDDVQKKL 1768
Cdd:COG1196   414 ERLERLEEELEELEEALAELEEEE 437
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1203-1753 5.72e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 48.39  E-value: 5.72e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1203 QFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLK 1282
Cdd:COG1196   233 KLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARLEQDIARLEERRR 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1283 NFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDAT 1362
Cdd:COG1196   313 ELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEAL 392

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1363 IRTLQENNHRLSDSIAATSELERKEhEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQ 1442
Cdd:COG1196   393 RAAAELAAQLEELEEAEEALLERLE-RLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEE 471

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1443 AVTNLKERILILEmDIGKLKGENEKIVETYRGKETEYQALQETNMKFSmmLREKEFECHSMKEKALAFEQLLKEKEQGKT 1522
Cdd:COG1196   472 AALLEAALAELLE-ELAEAAARLLLLLEAEADYEGFLEGVKAALLLAG--LRGLAGAVAVLIGVEAAYEAALEAALAAAL 548

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAA 1602
Cdd:COG1196   549 QNIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLV 628

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1603 EDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLnvvSKQRDETALQLSVSQEQVKQYALSLANLQMVLEH 1682
Cdd:COG1196   629 AARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELL---AALLEAEAELEELAERLAEEELELEEALLAEEEE 705

                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 190194412 1683 FQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQEcLDEANAALDSASRLTEQLDVKEEQIEELKRQ 1753
Cdd:COG1196   706 ERELAEAEEERLEEELEEEALEEQLEAEREELLEELLEE-EELLEEEALEELPEPPDLEELERELERLERE 775
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 419-641 1.09e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 46.68  E-value: 1.09e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  419 KLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEyevIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIE 498
Cdd:COG4942    31 QLQQEIAELEKELAALKKEEKALLKQLAALERR---IAALARRIRALEQELAALEAELAELEKEIAELRAELEAQKEELA 107

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  499 ELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTK 578
Cdd:COG4942   108 ELLRALYRLGRQPPLALLLSPEDFLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEAERAELEALLAELEEER 187

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 190194412  579 QKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKD 641
Cdd:COG4942   188 AALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAAAAAERTPAAGFAA 250
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 208-929 1.12e-04

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 47.42  E-value: 1.12e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   208 QSEICKLQNIIKELKQNRSQEIDDHQHEMSV---LQNAHQQKLTEI--SRRHREE-LSDYEERIEEL-------ENLLQQ 274
Cdd:pfam15921  109 RQSVIDLQTKLQEMQMERDAMADIRRRESQSqedLRNQLQNTVHELeaAKCLKEDmLEDSNTQIEQLrkmmlshEGVLQE 188

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   275 GGSGVI---ETDLSKIYEmQKTIQVLQIEKVES--TKKMEQLEDKIKDINKKLSSAENDRDILRRE-QEQLNVEKRQIME 348
Cdd:pfam15921  189 IRSILVdfeEASGKKIYE-HDSMSTMHFRSLGSaiSKILRELDTEISYLKGRIFPVEDQLEALKSEsQNKIELLLQQHQD 267

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   349 ECENLKLE-------CSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQaLSDAENEIMRL-SSLNQDNSLAEDnlkl 420
Cdd:pfam15921  268 RIEQLISEheveitgLTEKASSARSQANSIQSQLEIIQEQARNQNSMYMRQ-LSDLESTVSQLrSELREAKRMYED---- 342

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   421 kmRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEvikstatrdiSLDSELHDLRLNLEAKEQEL------NQSISEKE--- 491
Cdd:pfam15921  343 --KIEELEKQLVLANSELTEARTERDQFSQESG----------NLDDQLQKLLADLHKREKELslekeqNKRLWDRDtgn 410

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   492 --TLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLkQDLNDEKKRVHQLeddkmdiTKELDVQKEKLIQSEV 569
Cdd:pfam15921  411 siTIDHLRRELDDRNMEVQRLEALLKAMKSECQGQMERQMAAI-QGKNESLEKVSSL-------TAQLESTKEMLRKVVE 482

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   570 ALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREA 649
Cdd:pfam15921  483 ELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSRVDLKLQELQHLKNEGDHLRNVQTECEALKLQMAEKDK 562

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   650 EVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEEClagnNQLSLEKNTIVETLKMEKGEIEAElcwaK 729
Cdd:pfam15921  563 VIEILRQQIENMTQLVGQHGRTAGAMQVEKAQLEKEINDRRLELQEF----KILKDKKDAKIRELEARVSDLELE----K 634

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   730 KRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQ---- 805
Cdd:pfam15921  635 VKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSLSEDYEVLKRNFRNKSEEMETTTNKLKMQLKSAQSELEQtrnt 714

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   806 -----------------LTQLINKKEIFIEKLKERSSKLQEELdkySQALRKNEILRQTIEEKDRSLGSMKEENNHLQEE 868
Cdd:pfam15921  715 lksmegsdghamkvamgMQKQITAKRGQIDALQSKIQFLEEAM---TNANKEKHFLKEEKNKLSQELSTVATEKNKMAGE 791

                          730       740       750       760       770       780
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 190194412   869 LERLREEQSRtapvadpktldsvteLASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQL 929
Cdd:pfam15921  792 LEVLRSQERR---------------LKEKVANMEVALDKASLQFAECQDIIQRQEQESVRL 837
PTZ00121 PTZ00121
MAEBL; Provisional
 222-667 1.15e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 47.44  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  222 KQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEK 301
Cdd:PTZ00121 1413 AAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKA 1492

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  302 VESTKKMEQLEDKIKDINK--KLSSAENDR--DILRREQEQLNVEKRQIMEEC----ENLKLECSKLQPSAVKQSDTMTE 373
Cdd:PTZ00121 1493 EEAKKKADEAKKAAEAKKKadEAKKAEEAKkaDEAKKAEEAKKADEAKKAEEKkkadELKKAEELKKAEEKKKAEEAKKA 1572

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  374 KERILAQSASVEEVFRLQQALSD------AENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMS--L 445
Cdd:PTZ00121 1573 EEDKNMALRKAEEAKKAEEARIEevmklyEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAeeL 1652

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  446 LKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIK---------- 515
Cdd:PTZ00121 1653 KKAEEENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKkaeeenkika 1732

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  516 DQLSKQQNEGDSIISKLKQDlNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHL------TKQKLEDKVENLV 589
Cdd:PTZ00121 1733 EEAKKEAEEDKKKAEEAKKD-EEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRrmevdkKIKDIFDNFANII 1811

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  590 D-------QLNKSQESNVSIQKENLELKEHIRQNEEELSR----IRNELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNl 658
Cdd:PTZ00121 1812 EggkegnlVINDSKEMEDSAIKEVADSKNMQLEEADAFEKhkfnKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEI- 1890


                  ....*....
gi 190194412  659 selEQLNEN 667
Cdd:PTZ00121 1891 ---EKIDKD 1896
SCP-1 pfam05483
Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major ...
 437-942 1.37e-04

Synaptonemal complex protein 1 (SCP-1); Synaptonemal complex protein 1 (SCP-1) is the major component of the transverse filaments of the synaptonemal complex. Synaptonemal complexes are structures that are formed between homologous chromosomes during meiotic prophase.


Pssm-ID: 114219 [Multi-domain]  Cd Length: 787  Bit Score: 47.02  E-value: 1.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   437 EKEELQMSLLKLNNEYEVIkSTATRDISLDSELHDLRLNLEAKE---------QELNQSISEKET----LIAEIEELDRQ 503
Cdd:pfam05483  177 EREETRQVYMDLNNNIEKM-ILAFEELRVQAENARLEMHFKLKEdhekiqhleEEYKKEINDKEKqvslLLIQITEKENK 255

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   504 NQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLED 583
Cdd:pfam05483  256 MKDLTFLLEESRDKANQLEEKTKLQDENLKELIEKKDHLTKELEDIKMSLQRSMSTQKALEEDLQIATKTICQLTEEKEA 335

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   584 KVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNEL----MQSLNQDSNSNFKDTLLKEREAEVRNLKQNLS 659
Cdd:pfam05483  336 QMEELNKAKAAHSFVVTEFEATTCSLEELLRTEQQRLEKNEDQLkiitMELQKKSSELEEMTKFKNNKEVELEELKKILA 415

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   660 ELEQL---NENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCwakkrlleea 736
Cdd:pfam05483  416 EDEKLldeKKQFEKIAEELKGKEQELIFLLQAREKEIHDLEIQLTAIKTSEEHYLKEVEDLKTELEKEKL---------- 485

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   737 nkyeKTIEELSNarnlnTSALQLEHEhliKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIF 816
Cdd:pfam05483  486 ----KNIELTAH-----CDKLLLENK---ELTQEASDMTLELKKHQEDIINCKKQEERMLKQIENLEEKEMNLRDELESV 553

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   817 IEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSM------KEENNHLQEELERLREEQSRTAPVADPKTLDS 890
Cdd:pfam05483  554 REEFIQKGDEVKCKLDKSEENARSIEYEVLKKEKQMKILENKcnnlkkQIENKNKNIEELHQENKALKKKGSAENKQLNA 633

                          490       500       510       520       530
                   ....*....|....*....|....*....|....*....|....*....|...
gi 190194412   891 VTELASEVS-QLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDE 942
Cdd:pfam05483  634 YEIKVNKLElELASAKQKFEEIIDNYQKEIEDKKISEEKLLEEVEKAKAIADE 686
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 205-442 1.39e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.14  E-value: 1.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   205 NSDQSEICKLQNIIKELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDYEERIEELENLLQQGGSGVIETDL 284
Cdd:pfam12128  660 DEKQSEKDKKNKALAERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIA 739

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   285 SKIYEMQKTIQVLQIEKVESTKK-------MEQLEDKIKDINKKLSSAENDRDILRR----EQEQLNVEKRQIMEECENL 353
Cdd:pfam12128  740 ARRSGAKAELKALETWYKRDLASlgvdpdvIAKLKREIRTLERKIERIAVRRQEVLRyfdwYQETWLQRRPRLATQLSNI 819

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   354 KLECSKLQPS-AVKQSDTMTEKERILAQS-ASVEEVFRLQQALSDAENEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEK 431
Cdd:pfam12128  820 ERAISELQQQlARLIADTKLRRAKLEMERkASEKQQVRLSENLRGLRCEMSKLATLKEDANSEQAQGSIGERLAQLEDLK 899

                          250
                   ....*....|.
gi 190194412   432 SLLSQEKEELQ 442
Cdd:pfam12128  900 LKRDYLSESVK 910
PRK10929 PRK10929
putative mechanosensitive channel protein; Provisional
 1511-1760 1.61e-04

putative mechanosensitive channel protein; Provisional


Pssm-ID: 236798 [Multi-domain]  Cd Length: 1109  Bit Score: 46.97  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1511 EQLLKEKEQGK-------TGELNQLLNAVKS-MQEKTVVFQQERDQV------MLALKQKQMENTALQNEVQRLRDKEFR 1576
Cdd:PRK10929   86 QQLNNERDEPRsvppnmsTDALEQEILQVSSqLLEKSRQAQQEQDRAreisdsLSQLPQQQTEARRQLNEIERRLQTLGT 165

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1577 SNQELERLRNHLLESEdsytrealaaedrEAKLRKKVTVLEEKLVSSSNAMENA----------SHQASVQVESLQEQLN 1646
Cdd:PRK10929  166 PNTPLAQAQLTALQAE-------------SAALKALVDELELAQLSANNRQELArlrselakkrSQQLDAYLQALRNQLN 232

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1647 VVSKQRDETALqlsvsqEQVKQYALSLANL-QMVLEHFQQEEkaMYSAELEKQKQ---LIAEWKKNAENLEGKVISLQEC 1722
Cdd:PRK10929  233 SQRQREAERAL------ESTELLAEQSGDLpKSIVAQFKINR--ELSQALNQQAQrmdLIASQQRQAASQTLQVRQALNT 304

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 190194412 1723 LDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEM 1760
Cdd:PRK10929  305 LREQSQWLGVSNALGEALRAQVARLPEMPKPQQLDTEM 342
PRK01156 PRK01156
chromosome segregation protein; Provisional
 411-987 1.61e-04

chromosome segregation protein; Provisional


Pssm-ID: 100796 [Multi-domain]  Cd Length: 895  Bit Score: 46.82  E-value: 1.61e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  411 NSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEK 490
Cdd:PRK01156  162 NSLERNYDKLKDVIDMLRAEISNIDYLEEKLKSSNLELENIKKQIADDEKSHSITLKEIERLSIEYNNAMDDYNNLKSAL 241

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  491 ETLIAEIEELDRQNQEATK---------------------HMILIKDQLSKQQNEGDSIIsKLKQDLNDEKKrvhQLEDD 549
Cdd:PRK01156  242 NELSSLEDMKNRYESEIKTaesdlsmeleknnyykeleerHMKIINDPVYKNRNYINDYF-KYKNDIENKKQ---ILSNI 317

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  550 KMDITKELDVQKeKLIQSEVALNDlHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQ 629
Cdd:PRK01156  318 DAEINKYHAIIK-KLSVLQKDYND-YIKKKSRYDDLNNQILELEGYEMDYNSYLKSIESLKKKIEEYSKNIERMSAFISE 395

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  630 SLN-QDSNSNFKDTLLKEREAEVRNLKQNLSELEQ----LNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLS 704
Cdd:PRK01156  396 ILKiQEIDPDAIKKELNEINVKLQDISSKVSSLNQriraLRENLDELSRNMEMLNGQSVCPVCGTTLGEEKSNHIINHYN 475

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  705 LEKNTIVEtlKMEKGEIEAELCWAKKRLLEEANKY--EKTIEELSNARNLNTSAlqlehEHLIKLNQKKDMEIAELKKNI 782
Cdd:PRK01156  476 EKKSRLEE--KIREIEIEVKDIDEKIVDLKKRKEYleSEEINKSINEYNKIESA-----RADLEDIKIKINELKDKHDKY 548

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  783 EQMDTDHKETK-DVLSSSLEEQKQLTQLINKkeIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEE-KDRSLGSMKE 860
Cdd:PRK01156  549 EEIKNRYKSLKlEDLDSKRTSWLNALAVISL--IDIETNRSRSNEIKKQLNDLESRLQEIEIGFPDDKSyIDKSIREIEN 626

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  861 ENNHLQEELERlreeqsrtapvadpktldsVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSlqeqkkeM 940
Cdd:PRK01156  627 EANNLNNKYNE-------------------IQENKILIEKLRGKIDNYKKQIAEIDSIIPDLKEITSRINDI-------E 680

                         570       580       590       600
                  ....*....|....*....|....*....|....*....|....*..
gi 190194412  941 DEFRYQHEQMNATHTQLFlEKDEEIKSLQKTIEQIKTQLHEERQDIQ 987
Cdd:PRK01156  681 DNLKKSRKALDDAKANRA-RLESTIEILRTRINELSDRINDINETLE 726
SMC_N pfam02463
RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The ...
 171-842 1.97e-04

RecF/RecN/SMC N terminal domain; This domain is found at the N terminus of SMC proteins. The SMC (structural maintenance of chromosomes) superfamily proteins have ATP-binding domains at the N- and C-termini, and two extended coiled-coil domains separated by a hinge in the middle. The eukaryotic SMC proteins form two kind of heterodimers: the SMC1/SMC3 and the SMC2/SMC4 types. These heterodimers constitute an essential part of higher order complexes, which are involved in chromatin and DNA dynamics. This family also includes the RecF and RecN proteins that are involved in DNA metabolism and recombination.


Pssm-ID: 426784 [Multi-domain]  Cd Length: 1161  Bit Score: 46.50  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   171 QQEINRLSNEVSRLESEVGHWRHIAQTSKAQGTDNSDQSEICKLQNIIKELKQNRSQEIDDHQhEMSVLQNAHQQKLTEI 250
Cdd:pfam02463  297 ELKSELLKLERRKVDDEEKLKESEKEKKKAEKELKKEKEEIEELEKELKELEIKREAEEEEEE-ELEKLQEKLEQLEEEL 375

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   251 SRRHREELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRD 330
Cdd:pfam02463  376 LAKKKLESERLSSAAKLKEEELELKSEEEKEAQLLLELARQLEDLLKEEKKEELEILEEEEESIELKQGKLTEEKEELEK 455

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   331 ILRREQEQLNVEKRqimEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVE------------EVFRLQQALSDAE 398
Cdd:pfam02463  456 QELKLLKDELELKK---SEDLLKETQLVKLQEQLELLLSRQKLEERSQKESKARSglkvllalikdgVGGRIISAHGRLG 532

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   399 NEIMRLSSLNQDNSLAEDNLKLKMRIEVLEKEK-------SLLSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHD 471
Cdd:pfam02463  533 DLGVAVENYKVAISTAVIVEVSATADEVEERQKlvralteLPLGARKLRLLIPKLKLPLKSIAVLEIDPILNLAQLDKAT 612

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   472 LRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKM 551
Cdd:pfam02463  613 LEADEDDKRAKVVEGILKDTELTKLKESAKAKESGLRKGVSLEEGLAEKSEVKASLSELTKELLEIQELQEKAESELAKE 692

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   552 DITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSqesnvsIQKENLELKEHIRQNEEELSRIRNELMQSL 631
Cdd:pfam02463  693 EILRRQLEIKKKEQREKEELKKLKLEAEELLADRVQEAQDKINE------ELKLLKQKIDEEEEEEEKSRLKKEEKEEEK 766

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   632 NQDSnsnfkdtLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEdvrhQLEECLAGNNQLSLEKNTIV 711
Cdd:pfam02463  767 SELS-------LKEKELAEEREKTEKLKVEEEKEEKLKAQEEELRALEEELKEEAE----LLEEEQLLIEQEEKIKEEEL 835

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   712 ETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKE 791
Cdd:pfam02463  836 EELALELKEEQKLEKLAEEELERLEEEITKEELLQELLLKEEELEEQKLKDELESKEEKEKEEKKELEEESQKLNLLEEK 915

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 190194412   792 TKDVLSSSLEEQKQLTQLIN-----KKEIFIEKLKERSSKLQEELDKYSQALRKNE 842
Cdd:pfam02463  916 ENEIEERIKEEAEILLKYEEepeelLLEEADEKEKEENNKEEEEERNKRLLLAKEE 971
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
1524-1753 2.83e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 46.06  E-value: 2.83e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1524 ELNQLLNAVKSMQEktvvfQQERDQVMLALKQKQMENTALQNEVQRLRDK--EFRSNQELERLRNHLLESEDSYTReala 1601
Cdd:COG4913   236 DLERAHEALEDARE-----QIELLEPIRELAERYAAARERLAELEYLRAAlrLWFAQRRLELLEAELEELRAELAR---- 306

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1602 AEDREAKLRKKVTVLEEKLVSSSNAMENASHQasvQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQmvle 1681
Cdd:COG4913   307 LEAELERLEARLDALREELDELEAQIRGNGGD---RLEQLEREIERLERELEERERRRARLEALLAALGLPLPASA---- 379

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 190194412 1682 hfqqeekamysAELEKQKQLIAEWKKNAENLEgkvislQECLDEANAALDSASRLTEQLDVKEEQIEELKRQ 1753
Cdd:COG4913   380 -----------EEFAALRAEAAALLEALEEEL------EALEEALAEAEAALRDLRRELRELEAEIASLERR 434
PRK09039 PRK09039
peptidoglycan -binding protein;
1635-1767 3.35e-04

peptidoglycan -binding protein;


Pssm-ID: 181619 [Multi-domain]  Cd Length: 343  Bit Score: 44.96  E-value: 3.35e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1635 SVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLehfqqeekAMYSAELEKQKQLIAEWKKNAENLEG 1714
Cdd:PRK09039   45 SREISGKDSALDRLNSQIAELADLLSLERQGNQDLQDSVANLRASL--------SAAEAERSRLQALLAELAGAGAAAEG 116

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 190194412 1715 KVISLQECLDEANAALDSASRlteQLDVKEEQIEELKRQNELRQEMLDDVQKK 1767
Cdd:PRK09039  117 RAGELAQELDSEKQVSARALA---QVELLNQQIAALRRQLAALEAALDASEKR 166
PRK03918 PRK03918
DNA double-strand break repair ATPase Rad50;
641-1228 3.68e-04

DNA double-strand break repair ATPase Rad50;


Pssm-ID: 235175 [Multi-domain]  Cd Length: 880  Bit Score: 45.83  E-value: 3.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  641 DTLLKEREAEVRNLKQ--NLSELEQLNENLKKV--AFDVKMEN-EKLVLACEDVRHQLEEclagNNQLSLEKNTIVETLK 715
Cdd:PRK03918  138 DAILESDESREKVVRQilGLDDYENAYKNLGEVikEIKRRIERlEKFIKRTENIEELIKE----KEKELEEVLREINEIS 213

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  716 MEKGEIEAELCWAKKRLLEeankYEKTIEELSNARNLNTSALQLEHEHLIKLNQKKDMeIAELKKNIEQMDTDHKEtkdv 795
Cdd:PRK03918  214 SELPELREELEKLEKEVKE----LEELKEEIEELEKELESLEGSKRKLEEKIRELEER-IEELKKEIEELEEKVKE---- 284

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  796 lsssLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELER---- 871
Cdd:PRK03918  285 ----LKELKEKAEEYIKLSEFYEEYLDELREIEKRLSRLEEEINGIEERIKELEEKEERLEELKKKLKELEKRLEEleer 360

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  872 ------LREEQSRTAPVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRY 945
Cdd:PRK03918  361 helyeeAKAKKEELERLKKRLTGLTPEKLEKELEELEKAKEEIEEEISKITARIGELKKEIKELKKAIEELKKAKGKCPV 440

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  946 QHEQMNATHTQLFLEK-DEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVQSL--------NIENGSEKHDLSKA 1016
Cdd:PRK03918  441 CGRELTEEHRKELLEEyTAELKRIEKELKEIEEKERKLRKELRELEKVLKKESELIKLkelaeqlkELEEKLKKYNLEEL 520

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1017 ETerlvkgiKERELEikLLNEKNISLTKQIDQLsKDEVGKLTQIIQQKDLEIQALHARISSTSHtqdvvyLQQQLQAYAM 1096
Cdd:PRK03918  521 EK-------KAEEYE--KLKEKLIKLKGEIKSL-KKELEKLEELKKKLAELEKKLDELEEELAE------LLKELEELGF 584

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1097 EREKvfaVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFE-----SSGQDMFRETIQNLSRIIREKDI 1171
Cdd:PRK03918  585 ESVE---ELEERLKELEPFYNEYLELKDAEKELEREEKELKKLEEELDKAFEelaetEKRLEELRKELEELEKKYSEEEY 661

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 190194412 1172 E-IDALSQKCQTLLAVLQTSSTGNEaggvnsNQFEELLQERDKLKQQVKKMEEWKQQV 1228
Cdd:PRK03918  662 EeLREEYLELSRELAGLRAELEELE------KRREEIKKTLEKLKEELEEREKAKKEL 713
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 774-987 4.26e-04

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 44.75  E-value: 4.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  774 EIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKdr 853
Cdd:COG4942    21 AAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAE-- 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  854 slgsmKEENNHLQEELERLREEQSRTAPVA------DPKTLDSVTELASEVS-----QLNTIKEHLEEeIKHHQKIIEDQ 922
Cdd:COG4942    99 -----LEAQKEELAELLRALYRLGRQPPLAlllspeDFLDAVRRLQYLKYLAparreQAEELRADLAE-LAALRAELEAE 172

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190194412  923 NQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQ 987
Cdd:COG4942   173 RAELEALLAELEEERAALEALKAERQKLLARLEKELAELAAELAELQQEAEELEALIARLEAEAA 237
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1010-1620 5.74e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 44.93  E-value: 5.74e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1010 KHDLSKAETERLVKGIKERELEIK-LLNEknisLTKQIDQLSKD-----EVGKLTQIIQQKDLEIQALHARisstshtqd 1083
Cdd:COG1196   169 KYKERKEEAERKLEATEENLERLEdILGE----LERQLEPLERQaekaeRYRELKEELKELEAELLLLKLR--------- 235

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1084 vvYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALIKLQDENKKLSTRFES--SGQDMFRETIQN 1161
Cdd:COG1196   236 --ELEAELEELEAELEELEAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELARleQDIARLEERRRE 313

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1162 LSRIIREKDIEIDALSQKCQTLLAVLQTSstgNEAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQ 1241
Cdd:COG1196   314 LEERLEELEEELAELEEELEELEEELEEL---EEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLE 390

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1242 LQEELHQLQAQVLVDSDNNSKLQVDYTGLIQSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASL 1321
Cdd:COG1196   391 ALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLE 470

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1322 LTPQSAECLRASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAATSELErKEHEQTDSEIKQLKEK 1401
Cdd:COG1196   471 EAALLEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVE-AAYEAALEAALAAALQ 549

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1402 QDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILI------LEMDIGKLKGENEKIVETYRGK 1475
Cdd:COG1196   550 NIVVEDDEVAAAAIEYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVdlvasdLREADARYYVLGDTLLGRTLVA 629

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1476 ETEYQALqETNMKFSMMLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQ 1555
Cdd:COG1196   630 ARLEAAL-RRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERE 708

                         570       580       590       600       610       620
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 190194412 1556 KQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDRE---AKLRKKVTVLEEKL 1620
Cdd:COG1196   709 LAEAEEERLEEELEEEALEEQLEAEREELLEELLEEEELLEEEALEELPEPpdlEELERELERLEREI 776
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 256-991 6.15e-04

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 44.96  E-value: 6.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   256 EELSDYEERIEELENLLQQGGSGVIETDLSKIYEMQKtiQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDIL--R 333
Cdd:TIGR00618  212 CMPDTYHERKQVLEKELKHLREALQQTQQSHAYLTQK--REAQEEQLKKQQLLKQLRARIEELRAQEAVLEETQERInrA 289

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   334 REQEQLNVEKRQIMEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEI--------MRLS 405
Cdd:TIGR00618  290 RKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAHVKQQSSIEEQRRLLQTLHSQEIHIrdahevatSIRE 369

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   406 SLNQDNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQmsllklnneyevikSTATRDISLDSELHDLRLNLEAKEQELnq 485
Cdd:TIGR00618  370 ISCQQHTLTQHIHTLQQQKTTLTQKLQSLCKELDILQ--------------REQATIDTRTSAFRDLQGQLAHAKKQQ-- 433

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   486 sisEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDEKKRVHQLEDDKMDITKELDVQ-KEKL 564
Cdd:TIGR00618  434 ---ELQQRYAELCAAAITCTAQCEKLEKIHLQESAQSLKEREQQLQTKEQIHLQETRKKAVVLARLLELQEEPCPlCGSC 510

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   565 IQSEVALNDLHLTkQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELmQSLNQdsnsnfKDTLL 644
Cdd:TIGR00618  511 IHPNPARQDIDNP-GPLTRRMQRGEQTYAQLETSEEDVYHQLTSERKQRASLKEQMQEIQQSF-SILTQ------CDNRS 582

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   645 KEREAEVRNLKQNLSELEQLNENLKKvafdvkmeneklVLACEDVRHQLEECLAGNNQ-LSLEKNTIVETLKMEKGEIEA 723
Cdd:TIGR00618  583 KEDIPNLQNITVRLQDLTEKLSEAED------------MLACEQHALLRKLQPEQDLQdVRLHLQQCSQELALKLTALHA 650

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   724 ELCWAKKRLLEEANKYEKTIEELSNARNLNtsalqlehehLIKLNQKKDMEIAELKKNIEQMDTDHKEtkdVLSSSLEEQ 803
Cdd:TIGR00618  651 LQLTLTQERVREHALSIRVLPKELLASRQL----------ALQKMQSEKEQLTYWKEMLAQCQTLLRE---LETHIEEYD 717

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   804 KQLTQLINKKEIFIEKLKERSSKLQEELDKYsQALRKNEILRQTIEEKDRSLGSMKEENNHLQEELERLREEQSRtapva 883
Cdd:TIGR00618  718 REFNEIENASSSLGSDLAAREDALNQSLKEL-MHQARTVLKARTEAHFNNNEEVTAALQTGAELSHLAAEIQFFN----- 791

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   884 dpktldsvTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMnathtqlfLEKDE 963
Cdd:TIGR00618  792 --------RLREEDTHLLKTLEAEIGQEIPSDEDILNLQCETLVQEEEQFLSRLEEKSATLGEITHQ--------LLKYE 855

                          730       740
                   ....*....|....*....|....*...
gi 190194412   964 EIKSLQKTIEQIKTQLHEERQDIQTDNS 991
Cdd:TIGR00618  856 ECSKQLAQLTQEQAKIIQLSDKLNGINQ 883
PTZ00121 PTZ00121
MAEBL; Provisional
 666-1401 6.98e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 6.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  666 ENLKKVAFDVKMENEKLVLA---CEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELCWAkkrllEEANKYE-- 740
Cdd:PTZ00121 1209 EEERKAEEARKAEDAKKAEAvkkAEEAKKDAEEAKKAEEERNNEEIRKFEEARMAHFARRQAAIKA-----EEARKADel 1283

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  741 KTIEELSNARNLNTSALQLEHEHLIKLNQKKDmEIAELKKNIEQMdtdhKETKDVLSSSLEEQKQLTQLINKK-EIFIEK 819
Cdd:PTZ00121 1284 KKAEEKKKADEAKKAEEKKKADEAKKKAEEAK-KADEAKKKAEEA----KKKADAAKKKAEEAKKAAEAAKAEaEAAADE 1358

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  820 LKERSSKLQEELDKYSQALRKNEILRQTIEEKDRSlgsmkEENNHLQEELERLREEQSRTApvADPKTLDSVTELASEVS 899
Cdd:PTZ00121 1359 AEAAEEKAEAAEKKKEEAKKKADAAKKKAEEKKKA-----DEAKKKAEEDKKKADELKKAA--AAKKKADEAKKKAEEKK 1431

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  900 QLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQmnATHTQLFLEKDEEIKslqKTIEQIKTQL 979
Cdd:PTZ00121 1432 KADEAKKKAEEAKKADEAKKKAEEAKKAEEAKKKAEEAKKADEAKKKAEE--AKKADEAKKKAEEAK---KKADEAKKAA 1506

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  980 HEERQDIQTDNSDifQETKVQSL-NIENGSEKHDLSKAETERLVKGIKERElEIKLLNEKnisltKQIDQLSKDEVGKLT 1058
Cdd:PTZ00121 1507 EAKKKADEAKKAE--EAKKADEAkKAEEAKKADEAKKAEEKKKADELKKAE-ELKKAEEK-----KKAEEAKKAEEDKNM 1578

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1059 QIIQQKDLEiQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHlKTEYHKMMDIVAAKEAALIKLQD 1138
Cdd:PTZ00121 1579 ALRKAEEAK-KAEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKK-KVEQLKKKEAEEKKKAEELKKAE 1656

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1139 ENKKLSTRFESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNE----------AGGVNSNQFEELL 1208
Cdd:PTZ00121 1657 EENKIKAAEEAKKAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEekkkaeelkkAEEENKIKAEEAK 1736

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1209 QERDKLK---QQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYT--------GLIQSYEQN 1277
Cdd:PTZ00121 1737 KEAEEDKkkaEEAKKDEEEKKKIAHLKKEEEKKAEEIRKEKEAVIEEELDEEDEKRRMEVDKKikdifdnfANIIEGGKE 1816

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1278 ETKLKNFGQELAQvqHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQELEELRKSLQ 1357
Cdd:PTZ00121 1817 GNLVINDSKEMED--SAIKEVADSKNMQLEEADAFEKHKFNKNNENGEDGNKEADFNKEKDLKEDDEEEIEEADEIEKID 1894

                         730       740       750       760
                  ....*....|....*....|....*....|....*....|....*...
gi 190194412 1358 ----EKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQLKEK 1401
Cdd:PTZ00121 1895 kddiEREIPNNNMAGKNNDIIDDKLDKDEYIKRDAEETREEIIKISKK 1942
PLN02939 PLN02939
transferase, transferring glycosyl groups
 980-1283 7.40e-04

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 44.51  E-value: 7.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  980 HEERQDIQTDNSDIFQETKVQslniENGSEKHDLSKAETERLVKGIKERELEIKLLNEKNISLTKQIDQLSKDEvGKLTQ 1059
Cdd:PLN02939   96 DHNRASMQRDEAIAAIDNEQQ----TNSKDGEQLSDFQLEDLVGMIQNAEKNILLLNQARLQALEDLEKILTEK-EALQG 170

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1060 IIQQKDLEIQALHARISSTSHTQ-DVVYLQQQLQAY----AMEREKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALI 1134
Cdd:PLN02939  171 KINILEMRLSETDARIKLAAQEKiHVEILEEQLEKLrnelLIRGATEGLCVHSLSKELDVLKEENMLLKDDIQFLKAELI 250

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1135 KLQDENKKLSTR------FESSGQDMFRETIQNLSRIIREKDIEIDALSQKCQTLLAVLQTSSTGNEAGGVNSNQFEELL 1208
Cdd:PLN02939  251 EVAETEERVFKLekerslLDASLRELESKFIVAQEDVSKLSPLQYDCWWEKVENLQDLLDRATNQVEKAALVLDQNQDLR 330

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190194412 1209 QERDKLKQQVKKMEEWKQQvMTTVQNMQHESAQLQEELHQlqaqvlVDSDNNSKLQVdYTGLIQSYEQNETKLKN 1283
Cdd:PLN02939  331 DKVDKLEASLKEANVSKFS-SYKVELLQQKLKLLEERLQA------SDHEIHSYIQL-YQESIKEFQDTLSKLKE 397
GRAB pfam10375
GRAB domain; The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type ...
 1774-1819 8.19e-04

GRAB domain; The GRAB (GRIP-related Arf-binding) domain is towards the C-terminus of Rud3 type proteins. This domain is related to the GRIP domain, but the conserved tyrosine residue found at position 4 in all GRIP domains is replaced by a leucine residue. The Arf small GTPase is localized to the cis-Golgi where it recruits proteins via their GRAB domain, as part of the transport of cargo from the endoplasmic reticulum to the plasma membrane.


Pssm-ID: 431241  Cd Length: 49  Bit Score: 39.13  E-value: 8.19e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 190194412  1774 SSEGKVDKVLMRNLFIGHFHTPK--NQRHEVLRLMGSILGVRREEMEQ 1819
Cdd:pfam10375    1 SSEDTVDRQLVTNLLLSFLSIPRgdTKKFEILQLIANLLEWDDEQREQ 48
Cast pfam10174
RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part ...
 481-861 9.34e-04

RIM-binding protein of the cytomatrix active zone; This is a family of proteins that form part of the CAZ (cytomatrix at the active zone) complex which is involved in determining the site of synaptic vesicle fusion. The C-terminus is a PDZ-binding motif that binds directly to RIM (a small G protein Rab-3A effector). The family also contains four coiled-coil domains.


Pssm-ID: 431111 [Multi-domain]  Cd Length: 766  Bit Score: 44.43  E-value: 9.34e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   481 QELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQ-------QNEGDSIISKL---KQDLNDEKKRVHQLEDDK 550
Cdd:pfam10174  296 QELSKKESELLALQTKLETLTNQNSDCKQHIEVLKESLTAKeqraailQTEVDALRLRLeekESFLNKKTKQLQDLTEEK 375

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   551 MDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQ-------------KENLELKEHI---- 613
Cdd:pfam10174  376 STLAGEIRDLKDMLDVKERKINVLQKKIENLQEQLRDKDKQLAGLKERVKSLQtdssntdtalttlEEALSEKERIierl 455

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   614 RQNEEELSRIRNELMQSLNQDsNSNFKDTL------LKEREAEVRNLKQNLSELEQlnENLKKVAFDVKMENEklvlace 687
Cdd:pfam10174  456 KEQREREDRERLEELESLKKE-NKDLKEKVsalqpeLTEKESSLIDLKEHASSLAS--SGLKKDSKLKSLEIA------- 525

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   688 dVRHQLEECLAGNNQLSLEKNT-IVETLKMEKGEIEAELCWAKKRLLEEANKYEKTIEELSNA---------------RN 751
Cdd:pfam10174  526 -VEQKKEECSKLENQLKKAHNAeEAVRTNPEINDRIRLLEQEVARYKEESGKAQAEVERLLGIlrevenekndkdkkiAE 604

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   752 LNTSALQLEHEHLIKLNQKKDMEIAELKKNIEQMDTDHKETKDVLSSSLEEQkqltqlinkkeifIEKLKERSSKLQEEL 831
Cdd:pfam10174  605 LESLTLRQMKEQNKKVANIKHGQQEMKKKGAQLLEEARRREDNLADNSQQLQ-------------LEELMGALEKTRQEL 671

                          410       420       430
                   ....*....|....*....|....*....|
gi 190194412   832 DKYSQALRKNEilrQTIEEKDRSLGSMKEE 861
Cdd:pfam10174  672 DATKARLSSTQ---QSLAEKDGHLTNLRAE 698
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
298-725 1.03e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 44.26  E-value: 1.03e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  298 QIEKVEST---KKMEQLEDKIKDINKKLSSAENDRDILRREQEQLNV---EKRQIMEECENLKLECSKLQpsavkQSDTM 371
Cdd:PRK02224  195 QIEEKEEKdlhERLNGLESELAELDEEIERYEEQREQARETRDEADEvleEHEERREELETLEAEIEDLR-----ETIAE 269

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  372 TEKERilaqSASVEEVFRLQQALSDAENEIM-RLSSLNQDNSLAEDnlkLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN 450
Cdd:PRK02224  270 TERER----EELAEEVRDLRERLEELEEERDdLLAEAGLDDADAEA---VEARREELEDRDEELRDRLEECRVAAQAHNE 342

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  451 EYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMIL-------IKDQLSKQQN 523
Cdd:PRK02224  343 EAESLREDADDLEERAEELREEAAELESELEEAREAVEDRREEIEELEEEIEELRERFGDAPVdlgnaedFLEELREERD 422

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  524 EGDSIISKLKQDLNDEKKRVHQ----LEDDK-------------MDITKELDVQKEKLiqsEVALNDLHLTKQKLEDKVE 586
Cdd:PRK02224  423 ELREREAELEATLRTARERVEEaealLEAGKcpecgqpvegsphVETIEEDRERVEEL---EAELEDLEEEVEEVEERLE 499

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  587 NLVDQlnKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKEREA------------EVRNL 654
Cdd:PRK02224  500 RAEDL--VEAEDRIERLEERREDLEELIAERRETIEEKRERAEELRERAAELEAEAEEKREAAaeaeeeaeeareEVAEL 577

                         410       420       430       440       450       460       470
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 190194412  655 KQNLSELEQLNENLKKVAfdvkmENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAEL 725
Cdd:PRK02224  578 NSKLAELKERIESLERIR-----TLLAAIADAEDEIERLREKREALAELNDERRERLAEKRERKRELEAEF 643
PLN02939 PLN02939
transferase, transferring glycosyl groups
 1515-1778 1.16e-03

transferase, transferring glycosyl groups


Pssm-ID: 215507 [Multi-domain]  Cd Length: 977  Bit Score: 44.12  E-value: 1.16e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1515 KEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQEL-----ERLRNHLL 1589
Cdd:PLN02939  120 KDGEQLSDFQLEDLVGMIQNAEKNILLLNQARLQALEDLEKILTEKEALQGKINILEMRLSETDARIklaaqEKIHVEIL 199

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1590 ESEDSYTREALAAE-----DREAKLRKKVTVLEEKLVSSSNAMEnASHQASVQVESLQEQLNVVSKQRD--ETALQ---- 1658
Cdd:PLN02939  200 EEQLEKLRNELLIRgategLCVHSLSKELDVLKEENMLLKDDIQ-FLKAELIEVAETEERVFKLEKERSllDASLReles 278

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1659 -LSVSQEQV-KQYALSLANLQMVLEHFQqeekAMYSAELEKQKQLIAEWKKNaENLEGKVISLQECLDEANAALDSASR- 1735
Cdd:PLN02939  279 kFIVAQEDVsKLSPLQYDCWWEKVENLQ----DLLDRATNQVEKAALVLDQN-QDLRDKVDKLEASLKEANVSKFSSYKv 353

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*....
gi 190194412 1736 --LTEQLDVKEEQI----EELKRQNELRQEMLDDVQKKLMSLANSSEGK 1778
Cdd:PLN02939  354 elLQQKLKLLEERLqasdHEIHSYIQLYQESIKEFQDTLSKLKEESKKR 402
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 529-746 1.21e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.60  E-value: 1.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  529 ISKLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKsqesnvsIQKENLE 608
Cdd:COG4942    22 AAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAE-------LEKEIAE 94

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  609 LKEHIRQNEEELSRIRNELMQSLNQD------SNSNFKDT---------LLKEREAEVRNLKQNLSELEQLNENLKKvaf 673
Cdd:COG4942    95 LRAELEAQKEELAELLRALYRLGRQPplalllSPEDFLDAvrrlqylkyLAPARREQAEELRADLAELAALRAELEA--- 171

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 190194412  674 dvkmENEKLvlacEDVRHQLEECLAGNNQLSLEKNTIVETLKMEKGEIEAELcwakKRLLEEANKYEKTIEEL 746
Cdd:COG4942   172 ----ERAEL----EALLAELEEERAALEALKAERQKLLARLEKELAELAAEL----AELQQEAEELEALIARL 232
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
256-750 1.34e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 43.88  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  256 EELSDYEERIEELENLLQQggsgvIETDLSKIYEMQKTIQVLQIEKVESTKKMEQLEDKIKDINKKLSSAENDRDILRRE 335
Cdd:PRK02224  241 EVLEEHEERREELETLEAE-----IEDLRETIAETEREREELAEEVRDLRERLEELEEERDDLLAEAGLDDADAEAVEAR 315

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  336 QEQLNVEKrqimEECENLKLECSKLQPSAVKQSDTMTEKERILAQSASveevfRLQQALSDAENEImrlsslnqdNSLAE 415
Cdd:PRK02224  316 REELEDRD----EELRDRLEECRVAAQAHNEEAESLREDADDLEERAE-----ELREEAAELESEL---------EEARE 377

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  416 DNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTAtrdisldSELHDLRLNLEAKEQELNQSISEKETLIA 495
Cdd:PRK02224  378 AVEDRREEIEELEEEIEELRERFGDAPVDLGNAEDFLEELREER-------DELREREAELEATLRTARERVEEAEALLE 450

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  496 E---------------IEELDRQNQEATKHMILIkDQLSKQQNEGDSIISKLKqDLNDEKKRVHQLEDDKMDITKELDVQ 560
Cdd:PRK02224  451 AgkcpecgqpvegsphVETIEEDRERVEELEAEL-EDLEEEVEEVEERLERAE-DLVEAEDRIERLEERREDLEELIAER 528

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  561 KEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNelmqslnqdsnsnfk 640
Cdd:PRK02224  529 RETIEEKRERAEELRERAAELEAEAEEKREAAAEAEEEAEEAREEVAELNSKLAELKERIESLER--------------- 593

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  641 dtlLKEREAEVRNLKQnlsELEQLNENLKKVAFDVKMENEKLVLACEDVRhQLEECLAGNN--QLSLEKNTIVETLKMEK 718
Cdd:PRK02224  594 ---IRTLLAAIADAED---EIERLREKREALAELNDERRERLAEKRERKR-ELEAEFDEARieEAREDKERAEEYLEQVE 666

                         490       500       510
                  ....*....|....*....|....*....|..
gi 190194412  719 GEIEaELCWAKKRLLEEANKYEKTIEELSNAR 750
Cdd:PRK02224  667 EKLD-ELREERDDLQAEIGAVENELEELEELR 697
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 215-840 1.40e-03

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 43.67  E-value: 1.40e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   215 QNIIKELKQNRSQEIDDHQHEMSVLQNAHqqklteisrrhreELSDYEERIEELENLLQ--QGGSGVIETDLSKIYEMQK 292
Cdd:pfam12128  213 PPKSRLNRQQVEHWIRDIQAIAGIMKIRP-------------EFTKLQQEFNTLESAELrlSHLHFGYKSDETLIASRQE 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   293 TIQVLQIEKVESTKKME-QLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEE-CENLKLECSKLqPSAVKQSDT 370
Cdd:pfam12128  280 ERQETSAELNQLLRTLDdQWKEKRDELNGELSAADAAVAKDRSELEALEDQHGAFLDAdIETAAADQEQL-PSWQSELEN 358

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   371 MTEKERILAQSA-SVEEVFRLQQALSDAEN--EIMRLSSlNQDNSLAEDNLKLKMRIEVLEKeksLLSQEKEELQMSLLK 447
Cdd:pfam12128  359 LEERLKALTGKHqDVTAKYNRRRSKIKEQNnrDIAGIKD-KLAKIREARDRQLAVAEDDLQA---LESELREQLEAGKLE 434

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   448 LNNEYEVIKS------------TATRDISLDSELHDLRLnlEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIK 515
Cdd:pfam12128  435 FNEEEYRLKSrlgelklrlnqaTATPELLLQLENFDERI--ERAREEQEAANAEVERLQSELRQARKRRDQASEALRQAS 512

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   516 DQLSKQQNEGD-----------SIISKLKQDLNDEKKRVHQL-------------EDDKMDITKELDVQKEKLIQSEVAL 571
Cdd:pfam12128  513 RRLEERQSALDelelqlfpqagTLLHFLRKEAPDWEQSIGKVispellhrtdldpEVWDGSVGGELNLYGVKLDLKRIDV 592

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   572 NDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQS-LNQDSNSNfkdtllkEREAE 650
Cdd:pfam12128  593 PEWAASEEELRERLDKAEEALQSAREKQAAAEEQLVQANGELEKASREETFARTALKNArLDLRRLFD-------EKQSE 665

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   651 VRNLKQNL-SELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEEclagnnqLSLEKNTIVETLKMEKGEIEAELCWAK 729
Cdd:pfam12128  666 KDKKNKALaERKDSANERLNSLEAQLKQLDKKHQAWLEEQKEQKRE-------ARTEKQAYWQVVEGALDAQLALLKAAI 738

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   730 KRLLEEANKYEKTIEElSNARNLntSALQLEHEHLIKLNQkkdmEIAELKKNIEQMDTDHKET----------------- 792
Cdd:pfam12128  739 AARRSGAKAELKALET-WYKRDL--ASLGVDPDVIAKLKR----EIRTLERKIERIAVRRQEVlryfdwyqetwlqrrpr 811

                          650       660       670       680       690
                   ....*....|....*....|....*....|....*....|....*....|...
gi 190194412   793 -----KDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRK 840
Cdd:pfam12128  812 latqlSNIERAISELQQQLARLIADTKLRRAKLEMERKASEKQQVRLSENLRG 864
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 774-990 1.60e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 43.21  E-value: 1.60e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  774 EIAELKKNIEQMDTDHKETKDVLSSSLEEQKQLTQLINKKEIFIEKLKERSSKLQEELDKYSQALRKneiLRQTIEEKDR 853
Cdd:COG4942    35 EIAELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELRAELEA---QKEELAELLR 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  854 SLGSMKEENNHLQEELERLREEQSRTAPVAD---PKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLL 930
Cdd:COG4942   112 ALYRLGRQPPLALLLSPEDFLDAVRRLQYLKylaPARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALE 191

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  931 QSLQEQKKEMDEFRyqhEQMNATHTQLfLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDN 990
Cdd:COG4942   192 ALKAERQKLLARLE---KELAELAAEL-AELQQEAEELEALIARLEAEAAAAAERTPAAG 247
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
886-1304 1.66e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 43.22  E-value: 1.66e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  886 KTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIE--DQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNATHTQLfLEKDE 963
Cdd:COG4717    85 EKEEEYAELQEELEELEEELEELEAELEELREELEklEKLLQLLPLYQELEALEAELAELPERLEELEERLEEL-RELEE 163

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  964 EIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETkvqslniengsekhdlsKAETERLVKGIKERELEIKLLNEKNISLT 1043
Cdd:COG4717   164 ELEELEAELAELQEELEELLEQLSLATEEELQDL-----------------AEELEELQQRLAELEEELEEAQEELEELE 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1044 KQIDQLSKD-EVGKLTQIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTRENSHLKTE---- 1118
Cdd:COG4717   227 EELEQLENElEAAALEERLKEARLLLLIAAALLALLGLGGSLLSLILTIAGVLFLVLGLLALLFLLLAREKASLGKeaee 306

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1119 ---YHKMMDIVAAKEAALIKLQDENKKLSTRFESSGQDMFRETIQNLSRIIR-EKDIEIDALSQKCQTLLAvlqtsstgn 1194
Cdd:COG4717   307 lqaLPALEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEElEEELQLEELEQEIAALLA--------- 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1195 EAGGVNSNQFEELLQERDKLKQQVKKMEEWKQQVMTTVQNMQHESA-----QLQEELHQLQAQVlvdsdnnsklqvdytg 1269
Cdd:COG4717   378 EAGVEDEEELRAALEQAEEYQELKEELEELEEQLEELLGELEELLEaldeeELEEELEELEEEL---------------- 441

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 190194412 1270 liqsyEQNETKLKNFGQELAQVQHSIGQLCNTKDL 1304
Cdd:COG4717   442 -----EELEEELEELREELAELEAELEQLEEDGEL 471
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 478-670 1.76e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 42.83  E-value: 1.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  478 AKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSI---ISKLKQDLNDEKKRVHQLEDDKMDIT 554
Cdd:COG4942    17 AQADAAAEAEAELEQLQQEIAELEKELAALKKEEKALLKQLAALERRIAALarrIRALEQELAALEAELAELEKEIAELR 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  555 KELDVQKEKLIQSEVAlndlhLTKQKLEDKVENLV-----DQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQ 629
Cdd:COG4942    97 AELEAQKEELAELLRA-----LYRLGRQPPLALLLspedfLDAVRRLQYLKYLAPARREQAEELRADLAELAALRAELEA 171

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 190194412  630 SLNQdsnsnfKDTLLKEREAEVRNLKQNLSELEQLNENLKK 670
Cdd:COG4942   172 ERAE------LEALLAELEEERAALEALKAERQKLLARLEK 206
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 1353-1668 1.92e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.52  E-value: 1.92e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1353 RKSLQEKDATIRTLQENNHRLSDS---------------------IAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKE 1411
Cdd:TIGR02169  183 EENIERLDLIIDEKRQQLERLRRErekaeryqallkekreyegyeLLKEKEALERQKEAIERQLASLEEELEKLTEEISE 262

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1412 KDLLIKAKSDQLLSSNENFtNKVNENELLRqavtnlkeriliLEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSM 1491
Cdd:TIGR02169  263 LEKRLEEIEQLLEELNKKI-KDLGEEEQLR------------VKEKIGELEAEIASLERSIAEKERELEDAEERLAKLEA 329

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1492 MLREKEFECHSMkEKALAFEQLLKEKEQGKTGELNQLLNAVKS-MQEKTVVFQQERDQVMLALKQKQM---ENTALQNEV 1567
Cdd:TIGR02169  330 EIDKLLAEIEEL-EREIEEERKRRDKLTEEYAELKEELEDLRAeLEEVDKEFAETRDELKDYREKLEKlkrEINELKREL 408

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1568 QRLRDKEFRSNQELERLRNHLLESEDSYTREALAAEDREAKLRKKvtvlEEKLVSSSNAMENASHqasvQVESLQEQLNV 1647
Cdd:TIGR02169  409 DRLQEELQRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQ----EWKLEQLAADLSKYEQ----ELYDLKEEYDR 480

                          330       340
                   ....*....|....*....|.
gi 190194412  1648 VSKQRDETALQLSVSQEQVKQ 1668
Cdd:TIGR02169  481 VEKELSKLQRELAEAEAQARA 501
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1332-1768 2.76e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 43.00  E-value: 2.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1332 ASKSEVLSESSELLQQELEELRKSLQEKDATIRTLQENNHRLSDSIAAtselERKEHEQTDSEIKQLKEKQDVLQKLLKE 1411
Cdd:COG1196   252 EAELEELEAELAELEAELEELRLELEELELELEEAQAEEYELLAELAR----LEQDIARLEERRRELEERLEELEEELAE 327

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1412 KDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKFSM 1491
Cdd:COG1196   328 LEEELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEE 407

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1492 MLREKEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLR 1571
Cdd:COG1196   408 AEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELA 487

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1572 DKEFRSNQELERLRNHLLESEDSYTREALAAEDREAK----LRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNV 1647
Cdd:COG1196   488 EAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGavavLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAIEYLK 567

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1648 VSKQRDETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLIAEWKKNAENLEGKVISLQECLDEAN 1727
Cdd:COG1196   568 AAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLR 647

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 190194412 1728 AALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKL 1768
Cdd:COG1196   648 EVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERL 688
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
44-706 2.96e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   44 EVEAELPDSRTKEIEAIHAILRSENERLKKLCTDLEEKHEASEIQIKQQSTsyrNQLQQKEVEISHLKARQIALQDQLLK 123
Cdd:COG4913   287 QRRLELLEAELEELRAELARLEAELERLEARLDALREELDELEAQIRGNGG---DRLEQLEREIERLERELEERERRRAR 363

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  124 LQSAAQSVpsGAGVPATTAsssfaygishhpsafhdddmDFGDIIS-SQQEINRLSNEVSRLESEVghWRHIAQTSKAqg 202
Cdd:COG4913   364 LEALLAAL--GLPLPASAE--------------------EFAALRAeAAALLEALEEELEALEEAL--AEAEAALRDL-- 417

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  203 tdnsdQSEICKLQNIIKELKQNRSQeIDDHQHEMsvlqnahqqkLTEIsrrhREELSDYEERIEELENLLQQGGS----- 277
Cdd:COG4913   418 -----RRELRELEAEIASLERRKSN-IPARLLAL----------RDAL----AEALGLDEAELPFVGELIEVRPEeerwr 477

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  278 GVIET-----------------DLSKIYEMQKTIQVLQIEKVEST-KKMEQLEDKIKDINKKLSSAEND-RDILRRE--- 335
Cdd:COG4913   478 GAIERvlggfaltllvppehyaAALRWVNRLHLRGRLVYERVRTGlPDPERPRLDPDSLAGKLDFKPHPfRAWLEAElgr 557

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  336 ---------QEQLNVEKRQIMEECEnlklecsklqpsaVKQSDTMTEK--------ERILAQSAsveevfrlQQALSDAE 398
Cdd:COG4913   558 rfdyvcvdsPEELRRHPRAITRAGQ-------------VKGNGTRHEKddrrrirsRYVLGFDN--------RAKLAALE 616

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  399 NEImrlsslnqdNSLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMsLLKLNNEYEVIKSTATRDISLDSELHDLRLN--- 475
Cdd:COG4913   617 AEL---------AELEEELAEAEERLEALEAELDALQERREALQR-LAEYSWDEIDVASAEREIAELEAELERLDASsdd 686

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  476 LEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLKQDLNDE-KKRVHQLEDDKmdIT 554
Cdd:COG4913   687 LAALEEQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELRALlEERFAAALGDA--VE 764

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  555 KELDVQKEKLIQSEVALndlhltKQKLEDKVENLVDQLNK---SQESNVSIQKENLE--LKEHIRQNEEELSRIRNELMQ 629
Cdd:COG4913   765 RELRENLEERIDALRAR------LNRAEEELERAMRAFNRewpAETADLDADLESLPeyLALLDRLEEDGLPEYEERFKE 838

                         650       660       670       680       690       700       710       720
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  630 SLNQDSNsNFKDTLLKEREAEVRNLKQNlseLEQLNENLKKVAFDvkmENEKLVLACEDVRH--------QLEECLAGNN 701
Cdd:COG4913   839 LLNENSI-EFVADLLSKLRRAIREIKER---IDPLNDSLKRIPFG---PGRYLRLEARPRPDpevrefrqELRAVTSGAS 911


                  ....*
gi 190194412  702 QLSLE 706
Cdd:COG4913   912 LFDEE 916
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
441-853 3.22e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.45  E-value: 3.22e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  441 LQMSLLKLNNEYEVI-KSTATRDISLDSELHDLRLNL---EAKEQELNQSISEKETLIAEIEELDRQNQEATKHMILIKD 516
Cdd:COG4717    44 RAMLLERLEKEADELfKPQGRKPELNLKELKELEEELkeaEEKEEEYAELQEELEELEEELEELEAELEELREELEKLEK 123

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  517 QLSKQQNEGDsiISKLKQDLNDEKKRVHQLEddkmditKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENL----VDQL 592
Cdd:COG4717   124 LLQLLPLYQE--LEALEAELAELPERLEELE-------ERLEELRELEEELEELEAELAELQEELEELLEQLslatEEEL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  593 NKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQSLNQDSNSNFKDTLLKER-----EAEVRNLKQNLSELEQLNEN 667
Cdd:COG4717   195 QDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLKEARlllliAAALLALLGLGGSLLSLILT 274

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  668 LKKVAFDVK----MENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKmekgEIEAELCWAKKRLLEEANKYEKTI 743
Cdd:COG4717   275 IAGVLFLVLgllaLLFLLLAREKASLGKEAEELQALPALEELEEEELEELLA----ALGLPPDLSPEELLELLDRIEELQ 350

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  744 EELSNARNLNTSALQLEHEHLIK--LNQKKDMEIAELKKNIEQMDTDHKETKDV------LSSSLEEQKQLTQLINKKEI 815
Cdd:COG4717   351 ELLREAEELEEELQLEELEQEIAalLAEAGVEDEEELRAALEQAEEYQELKEELeeleeqLEELLGELEELLEALDEEEL 430

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|
gi 190194412  816 F--IEKLKERSSKLQEELDKYSQALRKNEILRQTIEEKDR 853
Cdd:COG4717   431 EeeLEELEEELEELEEELEELREELAELEAELEQLEEDGE 470
COG5022 COG5022
Myosin heavy chain [General function prediction only];
220-786 3.30e-03

Myosin heavy chain [General function prediction only];


Pssm-ID: 227355 [Multi-domain]  Cd Length: 1463  Bit Score: 42.76  E-value: 3.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  220 ELKQNRSQEIDDHQHEMSVLQNAHQQKLTEISRRHREELSDY-------EERIEELENLLQQggsgvIETDLSKIYEMQK 292
Cdd:COG5022   878 ELAERQLQELKIDVKSISSLKLVNLELESEIIELKKSLSSDLienlefkTELIARLKKLLNN-----IDLEEGPSIEYVK 952

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  293 TIQVLQIEKVESTKKMEQLE-------------------DKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEecenl 353
Cdd:COG5022   953 LPELNKLHEVESKLKETSEEyedllkkstilvregnkanSELKNFKKELAELSKQYGALQESTKQLKELPVEVAE----- 1027

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  354 klecsklQPSAVKQSDTMTEKERILAQSASVEEVFRLQQALSDAENEIMrlsSLNQDNSLAEDNLKLKMRIeVLEKEKSL 433
Cdd:COG5022  1028 -------LQSASKIISSESTELSILKPLQKLKGLLLLENNQLQARYKAL---KLRRENSLLDDKQLYQLES-TENLLKTI 1096

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  434 LSQEKEELQMSLLKLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEATKHMIL 513
Cdd:COG5022  1097 NVKDLEVTNRNLVKPANVLQFIVAQMIKLNLLQEISKFLSQLVNTLEPVFQKLSVLQLELDGLFWEANLEALPSPPPFAA 1176

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  514 IKDQLSKQQNEGDsIISKLKQDLNDEKKRVHQLEDDKmdiTKELDVQKEKLIQSEVALNDLHLTKQKLED---------- 583
Cdd:COG5022  1177 LSEKRLYQSALYD-EKSKLSSSEVNDLKNELIALFSK---IFSGWPRGDKLKKLISEGWVPTEYSTSLKGfnnlnkkfdt 1252

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  584 ----KVENLVDQLNKSQESNVSIQKENLELKEHIRQNE--------EELSRIRNELMQSLNQDSNSNFKDTLLKEREAEV 651
Cdd:COG5022  1253 pasmSNEKLLSLLNSIDNLLSSYKLEEEVLPATINSLLqyinvglfNALRTKASSLRWKSATEVNYNSEELDDWCREFEI 1332

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  652 RNLKQNLSELEQLNENLKKVAFDVKMENEKLVLACEDVRHQLEECLAGNNQLSLEKNTIVETLKmekgEIEAELCWAKKR 731
Cdd:COG5022  1333 SDVDEELEELIQAVKVLQLLKDDLNKLDELLDACYSLNPAEIQNLKSRYDPADKENNLPKEILK----KIEALLIKQELQ 1408

                         570       580       590       600       610
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 190194412  732 L--LEEANKYEKTIEELSNARNLntsaLQLEHEHLIKlNQKKDMEIAEL-KKNIEQMD 786
Cdd:COG5022  1409 LslEGKDETEVHLSEIFSEEKSL----ISLDRNSIYK-EEVLSSLSALLtKEKIALLD 1461
PRK05771 PRK05771
V-type ATP synthase subunit I; Validated
 528-751 3.47e-03

V-type ATP synthase subunit I; Validated


Pssm-ID: 235600 [Multi-domain]  Cd Length: 646  Bit Score: 42.22  E-value: 3.47e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  528 IISKLKQDLNDEKKrvhqleddkmdITKELDVQKEKliQSEVALNDLHLTKQKLEDKVENLVDQLNksqesnvsiqkenl 607
Cdd:PRK05771   58 ALDKLRSYLPKLNP-----------LREEKKKVSVK--SLEELIKDVEEELEKIEKEIKELEEEIS-------------- 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  608 ELKEHIRQNEEELSRIR-----NELMQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQLNENLKKVAFDVKMENEKL 682
Cdd:PRK05771  111 ELENEIKELEQEIERLEpwgnfDLDLSLLLGFKYVSVFVGTVPEDKLEELKLESDVENVEYISTDKGYVYVVVVVLKELS 190

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 190194412  683 vlacEDVRHQLEECLAGNNQLSLEK--NTIVETLKMEKGEIEAELCWAKKRLLEEANKYEKTI----EELSNARN 751
Cdd:PRK05771  191 ----DEVEEELKKLGFERLELEEEGtpSELIREIKEELEEIEKERESLLEELKELAKKYLEELlalyEYLEIELE 261
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
213-663 4.09e-03

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.06  E-value: 4.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  213 KLQNIIKELKQNRsQEIDDHQHEMSVLQNAHQ-QKLTEISRRHREELSDYEERIEELENLLQQggsgvIETDLSKIYEMQ 291
Cdd:COG4717    96 ELEELEEELEELE-AELEELREELEKLEKLLQlLPLYQELEALEAELAELPERLEELEERLEE-----LRELEEELEELE 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  292 KTIQVLQIEKVESTKKM-EQLEDKIKDINKKLSSAENDRDILRREQEQLNVEKRQIMEECENLKLECSKLQPSAVKQsdt 370
Cdd:COG4717   170 AELAELQEELEELLEQLsLATEEELQDLAEELEELQQRLAELEEELEEAQEELEELEEELEQLENELEAAALEERLK--- 246

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  371 mtEKERILAQSASVEEVFRLQQALSDAENEIMRLsslnqdnslaednlkLKMRIEVLEKEKSLLSQEKEELQMSLLKLNN 450
Cdd:COG4717   247 --EARLLLLIAAALLALLGLGGSLLSLILTIAGV---------------LFLVLGLLALLFLLLAREKASLGKEAEELQA 309

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  451 EYEvikSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQNQEAtkhmilikdQLSKQQNEGDSIIS 530
Cdd:COG4717   310 LPA---LEELEEEELEELLAALGLPPDLSPEELLELLDRIEELQELLREAEELEEEL---------QLEELEQEIAALLA 377

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  531 KLKQDLNDEKKRVHQLEDDKMDITKELDVQKEKLiqsevalndlhltkQKLEDKVENLVDQLNKSQesnvsIQKENLELK 610
Cdd:COG4717   378 EAGVEDEEELRAALEQAEEYQELKEELEELEEQL--------------EELLGELEELLEALDEEE-----LEEELEELE 438

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|...
gi 190194412  611 EHIRQNEEELSRIRNELmQSLNQDSNSNFKDTLLKEREAEVRNLKQNLSELEQ 663
Cdd:COG4717   439 EELEELEEELEELREEL-AELEAELEQLEEDGELAELLQELEELKAELRELAE 490
CALCOCO1 pfam07888
Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are ...
 1402-1763 4.97e-03

Calcium binding and coiled-coil domain (CALCOCO1) like; Proteins found in this family are similar to the coiled-coil transcriptional coactivator protein coexpressed by Mus musculus (CoCoA/CALCOCO1). This protein binds to a highly conserved N-terminal domain of p160 coactivators, such as GRIP1, and thus enhances transcriptional activation by a number of nuclear receptors. CALCOCO1 has a central coiled-coil region with three leucine zipper motifs, which is required for its interaction with GRIP1 and may regulate the autonomous transcriptional activation activity of the C-terminal region.


Pssm-ID: 462303 [Multi-domain]  Cd Length: 488  Bit Score: 41.80  E-value: 4.97e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1402 QDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQAVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQA 1481
Cdd:pfam07888   33 QNRLEECLQERAELLQAQEAANRQREKEKERYKRDREQWERQRRELESRVAELKEELRQSREKHEELEEKYKELSASSEE 112

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1482 LQEtnmKFSMMLREKEFECHSMKEKALAFeQLLKEKEQGKTGELNQLLNAVKsmqektvvfqqerdQVMLALKQKQMENT 1561
Cdd:pfam07888  113 LSE---EKDALLAQRAAHEARIRELEEDI-KTLTQRVLERETELERMKERAK--------------KAGAQRKEEEAERK 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1562 ALQNEVQRLRDKEFRSNQELERLRNHLLESEDSytreALAAEDREAKLRKKVTVLEEKLVSSSNAME---------NASH 1632
Cdd:pfam07888  175 QLQAKLQQTEEELRSLSKEFQELRNSLAQRDTQ----VLQLQDTITTLTQKLTTAHRKEAENEALLEelrslqerlNASE 250

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1633 QAsvqVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLE----HFQQEEKAM-------------YSAEL 1695
Cdd:pfam07888  251 RK---VEGLGEELSSMAAQRDRTQAELHQARLQAAQLTLQLADASLALRegraRWAQERETLqqsaeadkdriekLSAEL 327

                          330       340       350       360       370       380       390
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 190194412  1696 EKQKQLIAEWKKNAENLEGKVISLQEC-----------LDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLDD 1763
Cdd:pfam07888  328 QRLEERLQEERMEREKLEVELGREKDCnrvqlsesrreLQELKASLRVAQKEKEQLQAEKQELLEYIRQLEQRLETVAD 406
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 1205-1772 5.52e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 5.52e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1205 EELLQERDKLKQQVKKMEEWKQqvmttvqnmqhesaqLQEELHQLQAQVLVDSDNNskLQVDYTGLIQSYEQNETKLKNF 1284
Cdd:COG1196   196 GELERQLEPLERQAEKAERYRE---------------LKEELKELEAELLLLKLRE--LEAELEELEAELEELEAELEEL 258

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1285 GQELAQVQHSIGQLcntKDLLLGKLDIISPQLSSASLLTPQSAECLRASKSEVLSESSELLQQE--LEELRKSLQEKDAT 1362
Cdd:COG1196   259 EAELAELEAELEEL---RLELEELELELEEAQAEEYELLAELARLEQDIARLEERRRELEERLEelEEELAELEEELEEL 335

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1363 IRTLQEnnhrlsdsIAATSELERKEHEQTDSEIKQLKEKQDVLQKLLKEKDLLIKAKSDQLLSSNENFTNKVNENELLRQ 1442
Cdd:COG1196   336 EEELEE--------LEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEELEELAEELLEALRAAAELAAQLEELEE 407

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1443 AVTNLKERILILEMDIGKLKGENEKIVETYRGKETEYQALQETNMKfsmmLREKEFECHSMKEKALAFEQLLKEKEQGKT 1522
Cdd:COG1196   408 AEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAE----LEEEEEALLELLAELLEEAALLEAALAELL 483

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1523 GELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEFRSNQELERLRNHLLESEDSYTREALAA 1602
Cdd:COG1196   484 EELAEAAARLLLLLEAEADYEGFLEGVKAALLLAGLRGLAGAVAVLIGVEAAYEAALEAALAAALQNIVVEDDEVAAAAI 563

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1603 EDREAKLRKKVTVLEEKLVSSSNAMENASHQASVQVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANLQMVLEH 1682
Cdd:COG1196   564 EYLKAAKAGRATFLPLDKIRARAALAAALARGAIGAAVDLVASDLREADARYYVLGDTLLGRTLVAARLEAALRRAVTLA 643

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1683 FQQEEKAMYSAELEKQKQLIAEwkKNAENLEGKVISLQECLDEANAALDSASRLTEQLDVKEEQIEELKRQNELRQEMLD 1762
Cdd:COG1196   644 GRLREVTLEGEGGSAGGSLTGG--SRRELLAALLEAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEEL 721

                         570
                  ....*....|
gi 190194412 1763 DVQKKLMSLA 1772
Cdd:COG1196   722 EEEALEEQLE 731
rad50 TIGR00606
rad50; All proteins in this family for which functions are known are involvedin recombination, ...
 1059-1768 5.71e-03

rad50; All proteins in this family for which functions are known are involvedin recombination, recombinational repair, and/or non-homologous end joining.They are components of an exonuclease complex with MRE11 homologs. This family is distantly related to the SbcC family of bacterial proteins.This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University).


Pssm-ID: 129694 [Multi-domain]  Cd Length: 1311  Bit Score: 41.96  E-value: 5.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1059 QIIQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAME----REKVFAVLNEKTRENSHLKTEYHKMMDIVAAKEAALI 1134
Cdd:TIGR00606  200 QKVQEHQMELKYLKQYKEKACEIRDQITSKEAQLESSREivksYENELDPLKNRLKEIEHNLSKIMKLDNEIKALKSRKK 279

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1135 KLQDENKKLSTRFESSGQ---DMFRETIQNLSRIIREK--------------DIEIDALSQKCQTLLAVLQTSSTGNEAG 1197
Cdd:TIGR00606  280 QMEKDNSELELKMEKVFQgtdEQLNDLYHNHQRTVREKerelvdcqreleklNKERRLLNQEKTELLVEQGRLQLQADRH 359

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1198 GVNSNQFEELLQ------ERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQAQVLVDSDNNSKLQVDYTGLI 1271
Cdd:TIGR00606  360 QEHIRARDSLIQslatrlELDGFERGPFSERQIKNFHTLVIERQEDEAKTAAQLCADLQSKERLKQEQADEIRDEKKGLG 439

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1272 QSYEQNETKLKNFGQELAQVQHSIGQLCNTKDLLLGKLDIISPQLSSASLLTPQS-AECLRASKSEVLSESSELLQQELE 1350
Cdd:TIGR00606  440 RTIELKKEILEKKQEELKFVIKELQQLEGSSDRILELDQELRKAERELSKAEKNSlTETLKKEVKSLQNEKADLDRKLRK 519

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1351 ELRKsLQEKDATIRTLQENNHRLSDSIAATSELERKEHEQTDSEIKQL------KEKQDVLQKLLKEKDLLIKAKSD--- 1421
Cdd:TIGR00606  520 LDQE-MEQLNHHTTTRTQMEMLTKDKMDKDEQIRKIKSRHSDELTSLLgyfpnkKQLEDWLHSKSKEINQTRDRLAKlnk 598

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1422 QLLSSNENFTNKVNENELLRQAVTNLKERIL------ILEMDIGKLKGENEKivetYRGKETEYQALQETNMKFSMMLRE 1495
Cdd:TIGR00606  599 ELASLEQNKNHINNELESKEEQLSSYEDKLFdvcgsqDEESDLERLKEEIEK----SSKQRAMLAGATAVYSQFITQLTD 674

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1496 KEFECHSMKEKALAFEQLLKEKEQGKTGELNQLLNAVKSMQEKTVVFQQERDQVMLALKQKQMENTALQNEVQRLRDKEF 1575
Cdd:TIGR00606  675 ENQSCCPVCQRVFQTEAELQEFISDLQSKLRLAPDKLKSTESELKKKEKRRDEMLGLAPGRQSIIDLKEKEIPELRNKLQ 754

                          570       580       590       600       610       620       630       640
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1576 RSNQELERLRNHLLESEDSYtrEALAAEDREAK-LRKKVTVLEEKLVSSSNAMENASHQAS-VQVESLQEQLNVVSKQRD 1653
Cdd:TIGR00606  755 KVNRDIQRLKNDIEEQETLL--GTIMPEEESAKvCLTDVTIMERFQMELKDVERKIAQQAAkLQGSDLDRTVQQVNQEKQ 832

                          650       660       670       680       690       700       710       720
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1654 ETALQLSVSQEQVKQYALSLANLQMVLEHFQQEEKAMYSAELEKQKQLiAEWKKNAENLEGKVISLQECL----DEANAA 1729
Cdd:TIGR00606  833 EKQHELDTVVSKIELNRKLIQDQQEQIQHLKSKTNELKSEKLQIGTNL-QRRQQFEEQLVELSTEVQSLIreikDAKEQD 911

                          730       740       750
                   ....*....|....*....|....*....|....*....
gi 190194412  1730 LDSASRLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKL 1768
Cdd:TIGR00606  912 SPLETFLEKDQQEKEELISSKETSNKKAQDKVNDIKEKV 950
46 PHA02562
endonuclease subunit; Provisional
 413-627 6.35e-03

endonuclease subunit; Provisional


Pssm-ID: 222878 [Multi-domain]  Cd Length: 562  Bit Score: 41.54  E-value: 6.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  413 LAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLLKLNNEYEVIKSTATRDISldsELHDLRLNLEAKEQELNQSISEket 492
Cdd:PHA02562  165 LSEMDKLNKDKIRELNQQIQTLDMKIDHIQQQIKTYNKNIEEQRKKNGENIA---RKQNKYDELVEEAKTIKAEIEE--- 238

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  493 LIAEIEELDRQNQEATKHMILIKDQLSKQQNEGDSIISKLK------------QDLNDEKKRVHQLEDDKMDITKEL--- 557
Cdd:PHA02562  239 LTDELLNLVMDIEDPSAALNKLNTAAAKIKSKIEQFQKVIKmyekggvcptctQQISEGPDRITKIKDKLKELQHSLekl 318

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  558 DVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNEL 627
Cdd:PHA02562  319 DTAIDELEEIMDEFNEQSKKLLELKNKISTNKQSLITLVDKAKKVKAAIEELQAEFVDNAEELAKLQDEL 388
bHLHzip_Myc cd11400
basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a ...
 64-123 6.58e-03

basic Helix-Loop-Helix-zipper (bHLHzip) domain found in the Myc family; The Myc family is a member of the bHLHzip family of transcription factors that play important roles in the control of normal cell proliferation, growth, survival and differentiation. All Myc isoforms contain two independently functioning polypeptide chain regions: N-terminal transactivating residues and a C-terminal bHLHzip segment. The bHLHzip family of bHLH transcription factors are characterized by a highly conserved N-terminal basic region that may bind DNA at a consensus hexanucleotide sequence known as the E-box (CANNTG) followed by HLH and leucine zipper motifs that may interact with other proteins to form homo- and heterodimers. Myc heterodimerizes with Max enabling specific binding to E-box DNA sequences in the promoters of target genes. The Myc proto-oncoprotein family includes at least five different functional members: c-, N-, L-, S- and B-Myc (which is lacking the bHLH domain).


Pssm-ID: 381406 [Multi-domain]  Cd Length: 80  Bit Score: 37.53  E-value: 6.58e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   64 LRSENERLKKLCTDLEEKHEASEIQIKQQSTSYRNQLQQKEVEISHLKARQIALQDQLLK 123
Cdd:cd11400    16 LKNSFEKLRDLVPELADNEKASKVVILKKATEYIKQLQQEEKKLEKEKDKLKARNEQLRK 75
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 447-630 6.92e-03

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 40.97  E-value: 6.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  447 KLNNEYEVIKSTATRDISLDSELHDLRLNLEAKEQELNQSISEKETLIAEI----EELDRQNQEATKHMILIKDQLSKQQ 522
Cdd:COG3883    17 QIQAKQKELSELQAELEAAQAELDALQAELEELNEEYNELQAELEALQAEIdklqAEIAEAEAEIEERREELGERARALY 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  523 NEGDSI------------------ISKLKQDLNDEKKRVHQLEDDKmditKELDVQKEKLiqsEVALNDLHLTKQKLEDK 584
Cdd:COG3883    97 RSGGSVsyldvllgsesfsdfldrLSALSKIADADADLLEELKADK----AELEAKKAEL---EAKLAELEALKAELEAA 169

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*.
gi 190194412  585 VENLVDQLNKSQESNVSIQKENLELKEHIRQNEEELSRIRNELMQS 630
Cdd:COG3883   170 KAELEAQQAEQEALLAQLSAEEAAAEAQLAELEAELAAAEAAAAAA 215
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
371-657 6.99e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 41.44  E-value: 6.99e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  371 MTEKERILAQSASVEEVF----RLQQALSDAENEIMRLSSLNQdnsLAEDNLKLKMRIEVLEKEKSLLSQEKEELQMSLL 446
Cdd:COG4913   217 MLEEPDTFEAADALVEHFddleRAHEALEDAREQIELLEPIRE---LAERYAAARERLAELEYLRAALRLWFAQRRLELL 293

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  447 KlnneyevikstatrdisldSELHDLRLNLEAKEQELNQSISEKETLIAEIEELDRQnqeatkhmilikdqlsKQQNEGD 526
Cdd:COG4913   294 E-------------------AELEELRAELARLEAELERLEARLDALREELDELEAQ----------------IRGNGGD 338

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  527 siisklkqdlndekkRVHQLEDDKMDITKELDVQKEKLIQSEVALNDLHLTKQKLEDKVENLVDQLNKSQEsnvsiqken 606
Cdd:COG4913   339 ---------------RLEQLEREIERLERELEERERRRARLEALLAALGLPLPASAEEFAALRAEAAALLE--------- 394

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|.
gi 190194412  607 lELKEHIRQNEEELSRIRNELMQSLNQdsnsnfkdtlLKEREAEVRNLKQN 657
Cdd:COG4913   395 -ALEEELEALEEALAEAEAALRDLRRE----------LRELEAEIASLERR 434
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
1603-1771 7.67e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 41.16  E-value: 7.67e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1603 EDREAKLRKKVTVLEEKLVS--SSNAMENASHQASV---QVESLQEQLNVVSKQRDETALQLSVSQEQVKQYALSLANL- 1676
Cdd:COG3206   181 EEQLPELRKELEEAEAALEEfrQKNGLVDLSEEAKLllqQLSELESQLAEARAELAEAEARLAALRAQLGSGPDALPELl 260

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412 1677 -----QMVLEHFQQ------EEKAMYS----------AELEKQKQLI-AEWKKNAENLEGKVISLQECLDEANAALDSAS 1734
Cdd:COG3206   261 qspviQQLRAQLAEleaelaELSARYTpnhpdvialrAQIAALRAQLqQEAQRILASLEAELEALQAREASLQAQLAQLE 340

                         170       180       190
                  ....*....|....*....|....*....|....*..
gi 190194412 1735 RLTEQLDVKEEQIEELKRQNELRQEMLDDVQKKLMSL 1771
Cdd:COG3206   341 ARLAELPELEAELRRLEREVEVARELYESLLQRLEEA 377
CCDC158 pfam15921
Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. ...
 720-1282 8.15e-03

Coiled-coil domain-containing protein 158; CCDC158 is a family of proteins found in eukaryotes. The function is not known.


Pssm-ID: 464943 [Multi-domain]  Cd Length: 1112  Bit Score: 41.26  E-value: 8.15e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   720 EIEAELCWAKKRLLEEANKYEKTIEELSNARNLNTSALQLEHEHLIKLNQkkdmEIAELKKNIEQMDTDHKETKDVLSSS 799
Cdd:pfam15921  321 DLESTVSQLRSELREAKRMYEDKIEELEKQLVLANSELTEARTERDQFSQ----ESGNLDDQLQKLLADLHKREKELSLE 396

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   800 LEEQKQLTQLINKKEIFIEKLKErssklqeELDKYSQALRKNEILRQTIeeKDRSLGSMKEEnnhlqeelerlreeqsRT 879
Cdd:pfam15921  397 KEQNKRLWDRDTGNSITIDHLRR-------ELDDRNMEVQRLEALLKAM--KSECQGQMERQ----------------MA 451

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   880 APVADPKTLDSVTELASEVSQLNTIKEHLEEEIKHHQKIIEDQNQSKMQLLQSLQEQKKEMDEFRYQHEQMNA------T 953
Cdd:pfam15921  452 AIQGKNESLEKVSSLTAQLESTKEMLRKVVEELTAKKMTLESSERTVSDLTASLQEKERAIEATNAEITKLRSrvdlklQ 531

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412   954 HTQLFLEKDEEIKSLQKTIEQIKTQLHEERQDIQTDNSDIFQETKVqslnIENGSEKHDLSKAETERLVKGIKERELEI- 1032
Cdd:pfam15921  532 ELQHLKNEGDHLRNVQTECEALKLQMAEKDKVIEILRQQIENMTQL----VGQHGRTAGAMQVEKAQLEKEINDRRLELq 607

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1033 --KLLNEKNISLTKQIDQlskdevgkltqiiQQKDLEIQALHARISSTSHTQDVVYLQQQLQAYAMEREKVFAVLNEKTR 1110
Cdd:pfam15921  608 efKILKDKKDAKIRELEA-------------RVSDLELEKVKLVNAGSERLRAVKDIKQERDQLLNEVKTSRNELNSLSE 674

                          410       420       430       440       450       460       470       480
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1111 ENSHLKTEYH---KMMDIVAAK-----EAALIKLQDENKKLSTRFESSGQDMfrETIQNLSRIIREKDIEIDALSQKCQT 1182
Cdd:pfam15921  675 DYEVLKRNFRnksEEMETTTNKlkmqlKSAQSELEQTRNTLKSMEGSDGHAM--KVAMGMQKQITAKRGQIDALQSKIQF 752

                          490       500       510       520       530       540       550       560
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 190194412  1183 LlavlqtsstgnEAGGVNSNQFEELL-QERDKLKQQVKKMEEWKQQVMTTVQNMQHESAQLQEELHQLQaqvlVDSDNNS 1261
Cdd:pfam15921  753 L-----------EEAMTNANKEKHFLkEEKNKLSQELSTVATEKNKMAGELEVLRSQERRLKEKVANME----VALDKAS 817

                          570       580
                   ....*....|....*....|.
gi 190194412  1262 KLQVDYTGLIQSYEQNETKLK 1282
Cdd:pfam15921  818 LQFAECQDIIQRQEQESVRLK 838
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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