dystroglycan 1 preproprotein [Homo sapiens]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | |||||
| DAG1 | pfam05454 | Dystroglycan (Dystrophin-associated glycoprotein 1); Dystroglycan is one of the ... |
606-895 | 1.20e-163 | |||||
Dystroglycan (Dystrophin-associated glycoprotein 1); Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in human. The protein product is cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and [beta] (C-terminal). In skeletal muscle the dystroglycan complex works as a transmembrane linkage between the extracellular matrix and the cytoskeleton. [alpha]-dystroglycan is extracellular and binds to merosin ([alpha]-2 laminin) in the basement membrane, while [beta]-dystroglycan is a transmembrane protein and binds to dystrophin, which is a large rod-like cytoskeletal protein, absent in Duchenne muscular dystrophy patients. Dystrophin binds to intracellular actin cables. In this way, the dystroglycan complex, which links the extracellular matrix to the intracellular actin cables, is thought to provide structural integrity in muscle tissues. The dystroglycan complex is also known to serve as an agrin receptor in muscle, where it may regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction. There is also evidence which suggests the function of dystroglycan as a part of the signal transduction pathway because it is shown that Grb2, a mediator of the Ras-related signal pathway, can interact with the cytoplasmic domain of dystroglycan. In general, aberrant expression of dystrophin-associated protein complex underlies the pathogenesis of Duchenne muscular dystrophy, Becker muscular dystrophy and severe childhood autosomal recessive muscular dystrophy. Interestingly, no genetic disease has been described for either [alpha]- or [beta]-dystroglycan. Dystroglycan is widely distributed in non-muscle tissues as well as in muscle tissues. During epithelial morphogenesis of kidney, the dystroglycan complex is shown to act as a receptor for the basement membrane. Dystroglycan expression in mouse brain and neural retina has also been reported. However, the physiological role of dystroglycan in non-muscle tissues has remained unclear. : Pssm-ID: 461655 Cd Length: 290 Bit Score: 478.72 E-value: 1.20e-163
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| a_DG1_N2 | pfam18424 | Alpha-Dystroglycan N-terminal domain 2; This is the second N-terminal domain found in ... |
182-304 | 2.27e-76 | |||||
Alpha-Dystroglycan N-terminal domain 2; This is the second N-terminal domain found in alpha-Dystroglycan (DG). The murine skeletal muscle N-terminal alpha-DG region, contains two autonomous domains; the first identified as an Ig-like and the second resembling ribosomal RNA-binding proteins. This domain is similar to the small subunit ribosomal protein S6 of Thermus thermophilus (S6 domain). It is suggested that the S6 domain may be of functional relevance for LARGE (like-acetylglucosaminyltransferase) recognition along the alpha-DG maturation pathway. : Pssm-ID: 465761 Cd Length: 123 Bit Score: 244.40 E-value: 2.27e-76
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| Dystroglycan_repeat | cd11303 | Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely ... |
62-163 | 1.56e-40 | |||||
Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in skeletal muscle and other tissues; the pre-protein is cleaved into two subunits (alpha and beta) that form a complex which links the extracellular matrix to the cytoskeleton. Cadherin-like dystroglycan repeats are present in the extracellular alpha-dystroglycan subunit, which binds to the alpha-2-laminin G-domain in the basement membrane as part of the dystrophin-dystroglycan-complex (DGC). DGC has been shown to interact with other etxtracellular matrix components as well, such as perlecan and m-agrin, suggesting that the complex may play various different roles depending on the extracellular ligand. : Pssm-ID: 206636 [Multi-domain] Cd Length: 99 Bit Score: 144.04 E-value: 1.56e-40
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| Dystroglycan_repeat | cd11303 | Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely ... |
498-602 | 3.57e-29 | |||||
Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in skeletal muscle and other tissues; the pre-protein is cleaved into two subunits (alpha and beta) that form a complex which links the extracellular matrix to the cytoskeleton. Cadherin-like dystroglycan repeats are present in the extracellular alpha-dystroglycan subunit, which binds to the alpha-2-laminin G-domain in the basement membrane as part of the dystrophin-dystroglycan-complex (DGC). DGC has been shown to interact with other etxtracellular matrix components as well, such as perlecan and m-agrin, suggesting that the complex may play various different roles depending on the extracellular ligand. : Pssm-ID: 206636 [Multi-domain] Cd Length: 99 Bit Score: 111.68 E-value: 3.57e-29
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| PRK12323 super family | cl46901 | DNA polymerase III subunit gamma/tau; |
303-404 | 1.70e-04 | |||||
DNA polymerase III subunit gamma/tau; The actual alignment was detected with superfamily member PRK14971: Pssm-ID: 481241 [Multi-domain] Cd Length: 614 Bit Score: 45.15 E-value: 1.70e-04
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| Name | Accession | Description | Interval | E-value | |||||
| DAG1 | pfam05454 | Dystroglycan (Dystrophin-associated glycoprotein 1); Dystroglycan is one of the ... |
606-895 | 1.20e-163 | |||||
Dystroglycan (Dystrophin-associated glycoprotein 1); Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in human. The protein product is cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and [beta] (C-terminal). In skeletal muscle the dystroglycan complex works as a transmembrane linkage between the extracellular matrix and the cytoskeleton. [alpha]-dystroglycan is extracellular and binds to merosin ([alpha]-2 laminin) in the basement membrane, while [beta]-dystroglycan is a transmembrane protein and binds to dystrophin, which is a large rod-like cytoskeletal protein, absent in Duchenne muscular dystrophy patients. Dystrophin binds to intracellular actin cables. In this way, the dystroglycan complex, which links the extracellular matrix to the intracellular actin cables, is thought to provide structural integrity in muscle tissues. The dystroglycan complex is also known to serve as an agrin receptor in muscle, where it may regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction. There is also evidence which suggests the function of dystroglycan as a part of the signal transduction pathway because it is shown that Grb2, a mediator of the Ras-related signal pathway, can interact with the cytoplasmic domain of dystroglycan. In general, aberrant expression of dystrophin-associated protein complex underlies the pathogenesis of Duchenne muscular dystrophy, Becker muscular dystrophy and severe childhood autosomal recessive muscular dystrophy. Interestingly, no genetic disease has been described for either [alpha]- or [beta]-dystroglycan. Dystroglycan is widely distributed in non-muscle tissues as well as in muscle tissues. During epithelial morphogenesis of kidney, the dystroglycan complex is shown to act as a receptor for the basement membrane. Dystroglycan expression in mouse brain and neural retina has also been reported. However, the physiological role of dystroglycan in non-muscle tissues has remained unclear. Pssm-ID: 461655 Cd Length: 290 Bit Score: 478.72 E-value: 1.20e-163
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| a_DG1_N2 | pfam18424 | Alpha-Dystroglycan N-terminal domain 2; This is the second N-terminal domain found in ... |
182-304 | 2.27e-76 | |||||
Alpha-Dystroglycan N-terminal domain 2; This is the second N-terminal domain found in alpha-Dystroglycan (DG). The murine skeletal muscle N-terminal alpha-DG region, contains two autonomous domains; the first identified as an Ig-like and the second resembling ribosomal RNA-binding proteins. This domain is similar to the small subunit ribosomal protein S6 of Thermus thermophilus (S6 domain). It is suggested that the S6 domain may be of functional relevance for LARGE (like-acetylglucosaminyltransferase) recognition along the alpha-DG maturation pathway. Pssm-ID: 465761 Cd Length: 123 Bit Score: 244.40 E-value: 2.27e-76
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| alpha_DG_C | cd11305 | C-terminal domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in ... |
182-304 | 2.73e-62 | |||||
C-terminal domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in skeletal muscle and other tissues; the pre-protein is cleaved into two subunits (alpha and beta) that form a complex which links the extracellular matrix to the cytoskeleton. This C-terminal domain of the alpha-subunit appears to contact neighboring cadherin-like repeats of alpha dystroglycan, and may also be involved in interactions with other components of the dystrophin-dystroglycan-complex (DGC). DGC has been shown to interact with extracellular matrix components such as laminin, perlecan and m-agrin, suggesting that the complex may play various different roles depending on the extracellular ligand. Pssm-ID: 206765 Cd Length: 124 Bit Score: 206.03 E-value: 2.73e-62
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| Dystroglycan_repeat | cd11303 | Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely ... |
62-163 | 1.56e-40 | |||||
Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in skeletal muscle and other tissues; the pre-protein is cleaved into two subunits (alpha and beta) that form a complex which links the extracellular matrix to the cytoskeleton. Cadherin-like dystroglycan repeats are present in the extracellular alpha-dystroglycan subunit, which binds to the alpha-2-laminin G-domain in the basement membrane as part of the dystrophin-dystroglycan-complex (DGC). DGC has been shown to interact with other etxtracellular matrix components as well, such as perlecan and m-agrin, suggesting that the complex may play various different roles depending on the extracellular ligand. Pssm-ID: 206636 [Multi-domain] Cd Length: 99 Bit Score: 144.04 E-value: 1.56e-40
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| Dystroglycan_repeat | cd11303 | Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely ... |
498-602 | 3.57e-29 | |||||
Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in skeletal muscle and other tissues; the pre-protein is cleaved into two subunits (alpha and beta) that form a complex which links the extracellular matrix to the cytoskeleton. Cadherin-like dystroglycan repeats are present in the extracellular alpha-dystroglycan subunit, which binds to the alpha-2-laminin G-domain in the basement membrane as part of the dystrophin-dystroglycan-complex (DGC). DGC has been shown to interact with other etxtracellular matrix components as well, such as perlecan and m-agrin, suggesting that the complex may play various different roles depending on the extracellular ligand. Pssm-ID: 206636 [Multi-domain] Cd Length: 99 Bit Score: 111.68 E-value: 3.57e-29
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| CADG | smart00736 | Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan ... |
501-599 | 6.60e-24 | |||||
Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions. Pssm-ID: 214795 [Multi-domain] Cd Length: 97 Bit Score: 96.64 E-value: 6.60e-24
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| CADG | smart00736 | Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan ... |
64-162 | 6.24e-22 | |||||
Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions. Pssm-ID: 214795 [Multi-domain] Cd Length: 97 Bit Score: 90.86 E-value: 6.24e-22
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| He_PIG | pfam05345 | Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat ... |
61-156 | 8.04e-05 | |||||
Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei. Pssm-ID: 398814 [Multi-domain] Cd Length: 95 Bit Score: 42.46 E-value: 8.04e-05
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| PRK14971 | PRK14971 | DNA polymerase III subunit gamma/tau; |
303-404 | 1.70e-04 | |||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 45.15 E-value: 1.70e-04
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| Name | Accession | Description | Interval | E-value | |||||
| DAG1 | pfam05454 | Dystroglycan (Dystrophin-associated glycoprotein 1); Dystroglycan is one of the ... |
606-895 | 1.20e-163 | |||||
Dystroglycan (Dystrophin-associated glycoprotein 1); Dystroglycan is one of the dystrophin-associated glycoproteins, which is encoded by a 5.5 kb transcript in human. The protein product is cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and [beta] (C-terminal). In skeletal muscle the dystroglycan complex works as a transmembrane linkage between the extracellular matrix and the cytoskeleton. [alpha]-dystroglycan is extracellular and binds to merosin ([alpha]-2 laminin) in the basement membrane, while [beta]-dystroglycan is a transmembrane protein and binds to dystrophin, which is a large rod-like cytoskeletal protein, absent in Duchenne muscular dystrophy patients. Dystrophin binds to intracellular actin cables. In this way, the dystroglycan complex, which links the extracellular matrix to the intracellular actin cables, is thought to provide structural integrity in muscle tissues. The dystroglycan complex is also known to serve as an agrin receptor in muscle, where it may regulate agrin-induced acetylcholine receptor clustering at the neuromuscular junction. There is also evidence which suggests the function of dystroglycan as a part of the signal transduction pathway because it is shown that Grb2, a mediator of the Ras-related signal pathway, can interact with the cytoplasmic domain of dystroglycan. In general, aberrant expression of dystrophin-associated protein complex underlies the pathogenesis of Duchenne muscular dystrophy, Becker muscular dystrophy and severe childhood autosomal recessive muscular dystrophy. Interestingly, no genetic disease has been described for either [alpha]- or [beta]-dystroglycan. Dystroglycan is widely distributed in non-muscle tissues as well as in muscle tissues. During epithelial morphogenesis of kidney, the dystroglycan complex is shown to act as a receptor for the basement membrane. Dystroglycan expression in mouse brain and neural retina has also been reported. However, the physiological role of dystroglycan in non-muscle tissues has remained unclear. Pssm-ID: 461655 Cd Length: 290 Bit Score: 478.72 E-value: 1.20e-163
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| a_DG1_N2 | pfam18424 | Alpha-Dystroglycan N-terminal domain 2; This is the second N-terminal domain found in ... |
182-304 | 2.27e-76 | |||||
Alpha-Dystroglycan N-terminal domain 2; This is the second N-terminal domain found in alpha-Dystroglycan (DG). The murine skeletal muscle N-terminal alpha-DG region, contains two autonomous domains; the first identified as an Ig-like and the second resembling ribosomal RNA-binding proteins. This domain is similar to the small subunit ribosomal protein S6 of Thermus thermophilus (S6 domain). It is suggested that the S6 domain may be of functional relevance for LARGE (like-acetylglucosaminyltransferase) recognition along the alpha-DG maturation pathway. Pssm-ID: 465761 Cd Length: 123 Bit Score: 244.40 E-value: 2.27e-76
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| alpha_DG_C | cd11305 | C-terminal domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in ... |
182-304 | 2.73e-62 | |||||
C-terminal domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in skeletal muscle and other tissues; the pre-protein is cleaved into two subunits (alpha and beta) that form a complex which links the extracellular matrix to the cytoskeleton. This C-terminal domain of the alpha-subunit appears to contact neighboring cadherin-like repeats of alpha dystroglycan, and may also be involved in interactions with other components of the dystrophin-dystroglycan-complex (DGC). DGC has been shown to interact with extracellular matrix components such as laminin, perlecan and m-agrin, suggesting that the complex may play various different roles depending on the extracellular ligand. Pssm-ID: 206765 Cd Length: 124 Bit Score: 206.03 E-value: 2.73e-62
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| Dystroglycan_repeat | cd11303 | Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely ... |
62-163 | 1.56e-40 | |||||
Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in skeletal muscle and other tissues; the pre-protein is cleaved into two subunits (alpha and beta) that form a complex which links the extracellular matrix to the cytoskeleton. Cadherin-like dystroglycan repeats are present in the extracellular alpha-dystroglycan subunit, which binds to the alpha-2-laminin G-domain in the basement membrane as part of the dystrophin-dystroglycan-complex (DGC). DGC has been shown to interact with other etxtracellular matrix components as well, such as perlecan and m-agrin, suggesting that the complex may play various different roles depending on the extracellular ligand. Pssm-ID: 206636 [Multi-domain] Cd Length: 99 Bit Score: 144.04 E-value: 1.56e-40
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| CA_like | cd00031 | Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ... |
67-161 | 3.39e-30 | |||||
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan. Pssm-ID: 206635 Cd Length: 98 Bit Score: 114.75 E-value: 3.39e-30
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| Dystroglycan_repeat | cd11303 | Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely ... |
498-602 | 3.57e-29 | |||||
Cadherin-like repeat domain of alpha dystroglycan; Dystroglycan is a glycoprotein widely distributed in skeletal muscle and other tissues; the pre-protein is cleaved into two subunits (alpha and beta) that form a complex which links the extracellular matrix to the cytoskeleton. Cadherin-like dystroglycan repeats are present in the extracellular alpha-dystroglycan subunit, which binds to the alpha-2-laminin G-domain in the basement membrane as part of the dystrophin-dystroglycan-complex (DGC). DGC has been shown to interact with other etxtracellular matrix components as well, such as perlecan and m-agrin, suggesting that the complex may play various different roles depending on the extracellular ligand. Pssm-ID: 206636 [Multi-domain] Cd Length: 99 Bit Score: 111.68 E-value: 3.57e-29
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| CADG | smart00736 | Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan ... |
501-599 | 6.60e-24 | |||||
Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions. Pssm-ID: 214795 [Multi-domain] Cd Length: 97 Bit Score: 96.64 E-value: 6.60e-24
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| CADG | smart00736 | Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan ... |
64-162 | 6.24e-22 | |||||
Dystroglycan-type cadherin-like domains; Cadherin-homologous domains present in metazoan dystroglycans and alpha/epsilon sarcoglycans, yeast Axl2p and in a very large protein from magnetotactic bacteria. Likely to bind calcium ions. Pssm-ID: 214795 [Multi-domain] Cd Length: 97 Bit Score: 90.86 E-value: 6.24e-22
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| He_PIG | pfam05345 | Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat ... |
61-156 | 8.04e-05 | |||||
Putative Ig domain; This alignment represents the conserved core region of ~90 residue repeat found in several haemagglutinins and other cell surface proteins. Sequence similarities to (pfam02494) and (pfam00801) suggest an Ig-like fold (personal obs:C. Yeats). So this family may be similar in function to the (pfam02639) and (pfam02638) domains. This domain is also found in the WisP family of proteins of Tropheryma whipplei. Pssm-ID: 398814 [Multi-domain] Cd Length: 95 Bit Score: 42.46 E-value: 8.04e-05
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| PRK14971 | PRK14971 | DNA polymerase III subunit gamma/tau; |
303-404 | 1.70e-04 | |||||
DNA polymerase III subunit gamma/tau; Pssm-ID: 237874 [Multi-domain] Cd Length: 614 Bit Score: 45.15 E-value: 1.70e-04
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