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Conserved domains on  [gi|4758168|ref|NP_004396|]
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homeobox protein DLX-2 [Homo sapiens]

Protein Classification

DLL_N and homeodomain domain-containing protein( domain architecture ID 11193609)

DLL_N and homeodomain domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
153-209 7.07e-27

Homeodomain;


:

Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 100.27  E-value: 7.07e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4758168    153 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKK 209
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
DLL_N pfam12413
Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and ...
 51-132 3.25e-14

Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of a homeobox protein involved in embryonic development and adult neural regeneration.


:

Pssm-ID: 463567  Cd Length: 83  Bit Score: 67.07  E-value: 3.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758168     51 QESPTLPVSTATDSSYYTNQQHPAGGGGGGGSPYAHMGSYQY-QASGLNNV-PYSAKsSYDLGYTAAYTSYAPYGTSSSP 128
Cdd:pfam12413   1 QDSPTLPESSATDSGYYSPQQQHYYGSCAGQPYGQPLNSYQYfNLNGMNGTgAYSTK-AYEYGYNTSYRQYGAYGRSQSP 79


                  ....
gi 4758168    129 ANNE 132
Cdd:pfam12413  80 PPQD 83
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
153-209 7.07e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 100.27  E-value: 7.07e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4758168    153 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKK 209
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 153-208 1.27e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.54  E-value: 1.27e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 4758168     153 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFK 208
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 153-211 6.18e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 90.00  E-value: 6.18e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4758168  153 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMW 211
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
DLL_N pfam12413
Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and ...
 51-132 3.25e-14

Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of a homeobox protein involved in embryonic development and adult neural regeneration.


Pssm-ID: 463567  Cd Length: 83  Bit Score: 67.07  E-value: 3.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758168     51 QESPTLPVSTATDSSYYTNQQHPAGGGGGGGSPYAHMGSYQY-QASGLNNV-PYSAKsSYDLGYTAAYTSYAPYGTSSSP 128
Cdd:pfam12413   1 QDSPTLPESSATDSGYYSPQQQHYYGSCAGQPYGQPLNSYQYfNLNGMNGTgAYSTK-AYEYGYNTSYRQYGAYGRSQSP 79


                  ....
gi 4758168    129 ANNE 132
Cdd:pfam12413  80 PPQD 83
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
130-230 3.01e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 3.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758168  130 NNEPEKEDLEPEIR--IVNGKPKKVRKPRTiySSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKF 207
Cdd:COG5576  29 KREVEAADSEMKLErkQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKE 106

                        90       100
                ....*....|....*....|....*.
gi 4758168  208 KKMWKSGE---IPSEQHPGASASPPC 230
Cdd:COG5576 107 KKKRSGKVeqrPGEEEADLAKIGSLS 132
 
Name Accession Description Interval E-value
Homeodomain pfam00046
Homeodomain;
153-209 7.07e-27

Homeodomain;


Pssm-ID: 459649 [Multi-domain]  Cd Length: 57  Bit Score: 100.27  E-value: 7.07e-27
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 4758168    153 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKK 209
Cdd:pfam00046   1 RRKRTTFTPEQLEELEKEFQENPYPSAEEREELAAQLGLTERQVKVWFQNRRAKWKR 57
HOX smart00389
Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key ...
 153-208 1.27e-23

Homeodomain; DNA-binding factors that are involved in the transcriptional regulation of key developmental processes


Pssm-ID: 197696 [Multi-domain]  Cd Length: 57  Bit Score: 91.54  E-value: 1.27e-23
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 4758168     153 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFK 208
Cdd:smart00389   2 RRKRTSFTPEQLEELEKEFQKNPYPSREEREELAKKLGLSERQVKVWFQNRRAKWK 57
homeodomain cd00086
Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic ...
 153-211 6.18e-23

Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.


Pssm-ID: 238039 [Multi-domain]  Cd Length: 59  Bit Score: 90.00  E-value: 6.18e-23
                        10        20        30        40        50
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 4758168  153 RKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKFKKMW 211
Cdd:cd00086   1 RRKRTRFTPEQLEELEKEFEKNPYPSREEREELAKELGLTERQVKIWFQNRRAKLKRSE 59
DLL_N pfam12413
Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and ...
 51-132 3.25e-14

Homeobox protein distal-less-like N terminal; This domain family is found in eukaryotes, and is approximately 80 amino acids in length. The family is found in association with pfam00046. This family is the N terminal of a homeobox protein involved in embryonic development and adult neural regeneration.


Pssm-ID: 463567  Cd Length: 83  Bit Score: 67.07  E-value: 3.25e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758168     51 QESPTLPVSTATDSSYYTNQQHPAGGGGGGGSPYAHMGSYQY-QASGLNNV-PYSAKsSYDLGYTAAYTSYAPYGTSSSP 128
Cdd:pfam12413   1 QDSPTLPESSATDSGYYSPQQQHYYGSCAGQPYGQPLNSYQYfNLNGMNGTgAYSTK-AYEYGYNTSYRQYGAYGRSQSP 79


                  ....
gi 4758168    129 ANNE 132
Cdd:pfam12413  80 PPQD 83
COG5576 COG5576
Homeodomain-containing transcription factor [Transcription];
130-230 3.01e-11

Homeodomain-containing transcription factor [Transcription];


Pssm-ID: 227863 [Multi-domain]  Cd Length: 156  Bit Score: 60.91  E-value: 3.01e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758168  130 NNEPEKEDLEPEIR--IVNGKPKKVRKPRTiySSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNRRSKF 207
Cdd:COG5576  29 KREVEAADSEMKLErkQDGSSPPKSKRRRT--TDEQLMVLEREFEINPYPSSITRIKLSLLLNMPPKSVQIWFQNKRAKE 106

                        90       100
                ....*....|....*....|....*.
gi 4758168  208 KKMWKSGE---IPSEQHPGASASPPC 230
Cdd:COG5576 107 KKKRSGKVeqrPGEEEADLAKIGSLS 132
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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