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Conserved domains on  [gi|4758184|ref|NP_004403|]
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tRNA (cytosine(38)-C(5))-methyltransferase isoform a [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
4-391 3.07e-83

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


:

Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 255.24  E-value: 3.07e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    4 LRVLELYSGVGGMHHALRESCipAQVVAAIDVNTVANEVYKYNFPHTqLLAKTIEGITLEEFDrLSFDMILMSPPCQPFT 83
Cdd:cd00315   1 LRVIDLFAGIGGFRLGLEKAG--FEIVAANEIDKSAAETYEANFPNK-LIEGDITKIDEKDFI-PDIDLLTGGFPCQPFS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184   84 RIGRQGDMTDSRTNSFLHILDILPRLQklPKYILLENVKGFEV---SSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSR 160
Cdd:cd00315  77 IAGKRKGFEDTRGTLFFEIIRILKEKK--PKYFLLENVKGLLThdnGNTLKVILNTLEELGYNVYWKLLNASDYGVPQNR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184  161 LRYFLIAKLQSEPLPFQAPgqvlmefpkiesvhpqkyamdvenkiqeknvepnisfdgsiqcsgkdailfkletaeeihr 240
Cdd:cd00315 155 ERVFIIGIRKDLILNFFSP------------------------------------------------------------- 173
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184  241 knQQDSDLSVKMLKDFleddtdvnqyllppksllryallLDIVQPTCrRSVCFTKGYGSyieGTGSVLQTAEDvqveniy 320
Cdd:cd00315 174 --FPKPSEKKKTLKDI-----------------------LRIRDPDE-PSPTLTASYGK---GTGSVHPTAPD------- 217
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758184  321 ksltnlsqeeqiTKLLILKLRYFTPKEIANLLGFPPEFGFPEKiTVKQRYRLLGNSLNVHVVAKLIKILYE 391
Cdd:cd00315 218 ------------MIGKESNIRRLTPRECARLQGFPDDFEFPGK-SVTQAYRQIGNSVPVPVAEAIAKAIKE 275
 
Name Accession Description Interval E-value
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
4-391 3.07e-83

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 255.24  E-value: 3.07e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    4 LRVLELYSGVGGMHHALRESCipAQVVAAIDVNTVANEVYKYNFPHTqLLAKTIEGITLEEFDrLSFDMILMSPPCQPFT 83
Cdd:cd00315   1 LRVIDLFAGIGGFRLGLEKAG--FEIVAANEIDKSAAETYEANFPNK-LIEGDITKIDEKDFI-PDIDLLTGGFPCQPFS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184   84 RIGRQGDMTDSRTNSFLHILDILPRLQklPKYILLENVKGFEV---SSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSR 160
Cdd:cd00315  77 IAGKRKGFEDTRGTLFFEIIRILKEKK--PKYFLLENVKGLLThdnGNTLKVILNTLEELGYNVYWKLLNASDYGVPQNR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184  161 LRYFLIAKLQSEPLPFQAPgqvlmefpkiesvhpqkyamdvenkiqeknvepnisfdgsiqcsgkdailfkletaeeihr 240
Cdd:cd00315 155 ERVFIIGIRKDLILNFFSP------------------------------------------------------------- 173
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184  241 knQQDSDLSVKMLKDFleddtdvnqyllppksllryallLDIVQPTCrRSVCFTKGYGSyieGTGSVLQTAEDvqveniy 320
Cdd:cd00315 174 --FPKPSEKKKTLKDI-----------------------LRIRDPDE-PSPTLTASYGK---GTGSVHPTAPD------- 217
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758184  321 ksltnlsqeeqiTKLLILKLRYFTPKEIANLLGFPPEFGFPEKiTVKQRYRLLGNSLNVHVVAKLIKILYE 391
Cdd:cd00315 218 ------------MIGKESNIRRLTPRECARLQGFPDDFEFPGK-SVTQAYRQIGNSVPVPVAEAIAKAIKE 275
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
1-387 2.43e-39

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 141.48  E-value: 2.43e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    1 MEPLRVLELYSGVGGMHHALREscIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRlSFDMILMSPPCQ 80
Cdd:COG0270   1 SKKLTVIDLFAGAGGLSLGFEK--AGFEVVFAVEIDPDACETYRANFPEAKVIEGDIRDIDPEELIP-DVDLLIGGPPCQ 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184   81 PFTRIGRQGDMTDSRTNSFLHILDILPRLQklPKYILLENVKGFEVS---STRDLLIQTIENCGFQYQEFLLSPTSLGIP 157
Cdd:COG0270  78 PFSVAGKRKGLEDPRGTLFFEFIRIVEELR--PKAFVLENVPGLLSSdkgKTFEEILKELEELGYRVDYKVLNAADYGVP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184  158 NSRLRYFLIAKLQSEPLPfqapgqvlmEFPkiESVHPQKYamdvenkiqeknvepnisfdgsiqcsgkdailfkletaee 237
Cdd:COG0270 156 QNRERVFIVGFRKDLDLF---------EFP--EPTHLKPY---------------------------------------- 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184  238 ihrknqqdsdlsvKMLKDFLEDdtdvnqylLPPKSLLRYallldiVQPTCRRSVcftKGYGSYIEGTgsvlqtaedvqve 317
Cdd:COG0270 185 -------------VTVGDALED--------LPDAHEARY------LSETITAGY---GGGGRFLHPG------------- 221
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4758184  318 niyksltnlsqeeqitkllilKLRYFTPKEIANLLGFPPEFGFPEKITvkQRYRLLGNSLNV---HVVAKLIK 387
Cdd:COG0270 222 ---------------------EPRRLTVREAARLQGFPDDFKFPGSKT--QAYRQIGNAVPPplaEAIAKAIL 271
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
4-387 1.36e-27

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 111.25  E-value: 1.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184      4 LRVLELYSGVGGMHHALREscIPAQVVAAIDVNTVANEVYKYNFPhtqllaKTIEG-ITLEEFDRLS-FDMILMSPPCQP 81
Cdd:pfam00145   1 FKFIDLFAGIGGFRLGLEQ--AGFECVAANEIDKSAAKTYEANFP------KVPIGdITLIDIKDIPdIDILTGGFPCQD 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184     82 FTRIGRQGDMTDSRTNSFLHILDILPRLQklPKYILLENVKGFeVSS----TRDLLIQTIENCGFQYQEFLLSPTSLGIP 157
Cdd:pfam00145  73 FSIAGKQKGFEDTRGTLFFEIIRIIKEKK--PKAFLLENVKGL-LSHdngnTLNVILETLEELGYHVSWKVLNASDYGVP 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    158 NSRLRYFLIAKLQSEPLPFqapgqvlmEFPKIESVHPQKY-AMDVENKIQEKNVEPNISFDGSIqcsgkdailFKLETAE 236
Cdd:pfam00145 150 QNRERVFIVGIRKDLNLNV--------LVPVPEFDFPKPKdLTGTIRDLLEEPSLDENKYNLSD---------KFVENHE 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    237 EIHRKNQQD-SDLSVKMLKDfleddtdvnqyllppksllryallldivqptCRRSVCFTKGYGSYIEGTGsvlqtaeDVQ 315
Cdd:pfam00145 213 RRKPTTKAPgGGYPTYLLRN-------------------------------RIDKVEEGKGPSFTYRKSG-------RPE 254
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4758184    316 VENIYKSLTNLSQEEQITKLlilkLRYFTPKEIANLLGFPPEFGFPEKITvkQRYRLLGNSLNVHVVAKLIK 387
Cdd:pfam00145 255 APKTGILGKNGERFRGHPKN----IRRLTPRECARLQGFPDDFIFPGSKT--QLYKQIGNAVPVPVAEAIAK 320
dcm TIGR00675
DNA-methyltransferase (dcm); All proteins in this family for which functions are known are ...
6-387 4.37e-25

DNA-methyltransferase (dcm); All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273211 [Multi-domain]  Cd Length: 315  Bit Score: 103.95  E-value: 4.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184      6 VLELYSGVGGMHHALRESCIpaQVVAAIDVNTVANEVYKYNFPHtQLLAKTIEGITLEEFDrlSFDMILMSPPCQPFTRI 85
Cdd:TIGR00675   1 FIDLFAGIGGIRLGFEQAGF--KCVFASEIDKYAQKTYEANFGN-KVPFGDITKISPSDIP--DFDILLGGFPCQPFSIA 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184     86 GRQGDMTDSRTNSFLHILDILPrlQKLPKYILLENVKGFeVSS----TRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRL 161
Cdd:TIGR00675  76 GKRKGFEDTRGTLFFEIVRILK--EKKPKFFLLENVKGL-VSHdkgrTFKVIIETLEELGYKVYYKVLNAKDFGVPQNRE 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    162 RYFLIA-KLQSEPLPFqapgqvlmEFPKiesvhPQKYAMDVENKiqeKNVEPNISFDGSIQCSgkdailfkletaeeiHR 240
Cdd:TIGR00675 153 RIYIVGfRDFDDKLNF--------EFPK-----PIYVAKKKRIG---DLLDLSVDLEEKYYLS---------------EE 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    241 KNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALlldivqptcrrsvcfTKGYGSYIEGTGSVLQTAEDVQVEniy 320
Cdd:TIGR00675 202 KKNGLLLLLENMRKKEGTGEQIGSFYNRESKSSIIRTL---------------SARGYTFVKGGKSVLIVPHKSTVV--- 263
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4758184    321 ksltnlsQEEQITKLlilklryfTPKEIANLLGFPPEFGFPekITVKQRYRLLGNSLNVHVVAKLIK 387
Cdd:TIGR00675 264 -------HPGRIRRL--------TPRECARLQGFPDDFKFP--VSDSQLYKQAGNAVVVPVIEAIAK 313
PRK10458 PRK10458
DNA cytosine methylase; Provisional
341-387 2.69e-03

DNA cytosine methylase; Provisional


Pssm-ID: 236696 [Multi-domain]  Cd Length: 467  Bit Score: 39.66  E-value: 2.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4758184   341 RYFTPKEIANLLGFPPEFGFPEKITVK--QRYRLLGNSLNVHV---VAKLIK 387
Cdd:PRK10458 402 RRLTPRECARLMGFEAPGEAKFRIPVSdtQAYRQFGNSVVVPVfaaVAKLLE 453
 
Name Accession Description Interval E-value
Cyt_C5_DNA_methylase cd00315
Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many ...
4-391 3.07e-83

Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group to cytosine within the context of the CpG dinucleotide, has profound effects on the mammalian genome. These effects include transcriptional repression via inhibition of transcription factor binding or the recruitment of methyl-binding proteins and their associated chromatin remodeling factors, X chromosome inactivation, imprinting and the suppression of parasitic DNA sequences. DNA methylation is also essential for proper embryonic development and is an important player in both DNA repair and genome stability.


Pssm-ID: 238192 [Multi-domain]  Cd Length: 275  Bit Score: 255.24  E-value: 3.07e-83
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    4 LRVLELYSGVGGMHHALRESCipAQVVAAIDVNTVANEVYKYNFPHTqLLAKTIEGITLEEFDrLSFDMILMSPPCQPFT 83
Cdd:cd00315   1 LRVIDLFAGIGGFRLGLEKAG--FEIVAANEIDKSAAETYEANFPNK-LIEGDITKIDEKDFI-PDIDLLTGGFPCQPFS 76
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184   84 RIGRQGDMTDSRTNSFLHILDILPRLQklPKYILLENVKGFEV---SSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSR 160
Cdd:cd00315  77 IAGKRKGFEDTRGTLFFEIIRILKEKK--PKYFLLENVKGLLThdnGNTLKVILNTLEELGYNVYWKLLNASDYGVPQNR 154
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184  161 LRYFLIAKLQSEPLPFQAPgqvlmefpkiesvhpqkyamdvenkiqeknvepnisfdgsiqcsgkdailfkletaeeihr 240
Cdd:cd00315 155 ERVFIIGIRKDLILNFFSP------------------------------------------------------------- 173
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184  241 knQQDSDLSVKMLKDFleddtdvnqyllppksllryallLDIVQPTCrRSVCFTKGYGSyieGTGSVLQTAEDvqveniy 320
Cdd:cd00315 174 --FPKPSEKKKTLKDI-----------------------LRIRDPDE-PSPTLTASYGK---GTGSVHPTAPD------- 217
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 4758184  321 ksltnlsqeeqiTKLLILKLRYFTPKEIANLLGFPPEFGFPEKiTVKQRYRLLGNSLNVHVVAKLIKILYE 391
Cdd:cd00315 218 ------------MIGKESNIRRLTPRECARLQGFPDDFEFPGK-SVTQAYRQIGNSVPVPVAEAIAKAIKE 275
Dcm COG0270
DNA-cytosine methylase [Replication, recombination and repair];
1-387 2.43e-39

DNA-cytosine methylase [Replication, recombination and repair];


Pssm-ID: 440040 [Multi-domain]  Cd Length: 277  Bit Score: 141.48  E-value: 2.43e-39
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    1 MEPLRVLELYSGVGGMHHALREscIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRlSFDMILMSPPCQ 80
Cdd:COG0270   1 SKKLTVIDLFAGAGGLSLGFEK--AGFEVVFAVEIDPDACETYRANFPEAKVIEGDIRDIDPEELIP-DVDLLIGGPPCQ 77
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184   81 PFTRIGRQGDMTDSRTNSFLHILDILPRLQklPKYILLENVKGFEVS---STRDLLIQTIENCGFQYQEFLLSPTSLGIP 157
Cdd:COG0270  78 PFSVAGKRKGLEDPRGTLFFEFIRIVEELR--PKAFVLENVPGLLSSdkgKTFEEILKELEELGYRVDYKVLNAADYGVP 155
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184  158 NSRLRYFLIAKLQSEPLPfqapgqvlmEFPkiESVHPQKYamdvenkiqeknvepnisfdgsiqcsgkdailfkletaee 237
Cdd:COG0270 156 QNRERVFIVGFRKDLDLF---------EFP--EPTHLKPY---------------------------------------- 184
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184  238 ihrknqqdsdlsvKMLKDFLEDdtdvnqylLPPKSLLRYallldiVQPTCRRSVcftKGYGSYIEGTgsvlqtaedvqve 317
Cdd:COG0270 185 -------------VTVGDALED--------LPDAHEARY------LSETITAGY---GGGGRFLHPG------------- 221
                       330       340       350       360       370       380       390
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 4758184  318 niyksltnlsqeeqitkllilKLRYFTPKEIANLLGFPPEFGFPEKITvkQRYRLLGNSLNV---HVVAKLIK 387
Cdd:COG0270 222 ---------------------EPRRLTVREAARLQGFPDDFKFPGSKT--QAYRQIGNAVPPplaEAIAKAIL 271
DNA_methylase pfam00145
C-5 cytosine-specific DNA methylase;
4-387 1.36e-27

C-5 cytosine-specific DNA methylase;


Pssm-ID: 395093 [Multi-domain]  Cd Length: 324  Bit Score: 111.25  E-value: 1.36e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184      4 LRVLELYSGVGGMHHALREscIPAQVVAAIDVNTVANEVYKYNFPhtqllaKTIEG-ITLEEFDRLS-FDMILMSPPCQP 81
Cdd:pfam00145   1 FKFIDLFAGIGGFRLGLEQ--AGFECVAANEIDKSAAKTYEANFP------KVPIGdITLIDIKDIPdIDILTGGFPCQD 72
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184     82 FTRIGRQGDMTDSRTNSFLHILDILPRLQklPKYILLENVKGFeVSS----TRDLLIQTIENCGFQYQEFLLSPTSLGIP 157
Cdd:pfam00145  73 FSIAGKQKGFEDTRGTLFFEIIRIIKEKK--PKAFLLENVKGL-LSHdngnTLNVILETLEELGYHVSWKVLNASDYGVP 149
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    158 NSRLRYFLIAKLQSEPLPFqapgqvlmEFPKIESVHPQKY-AMDVENKIQEKNVEPNISFDGSIqcsgkdailFKLETAE 236
Cdd:pfam00145 150 QNRERVFIVGIRKDLNLNV--------LVPVPEFDFPKPKdLTGTIRDLLEEPSLDENKYNLSD---------KFVENHE 212
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    237 EIHRKNQQD-SDLSVKMLKDfleddtdvnqyllppksllryallldivqptCRRSVCFTKGYGSYIEGTGsvlqtaeDVQ 315
Cdd:pfam00145 213 RRKPTTKAPgGGYPTYLLRN-------------------------------RIDKVEEGKGPSFTYRKSG-------RPE 254
                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4758184    316 VENIYKSLTNLSQEEQITKLlilkLRYFTPKEIANLLGFPPEFGFPEKITvkQRYRLLGNSLNVHVVAKLIK 387
Cdd:pfam00145 255 APKTGILGKNGERFRGHPKN----IRRLTPRECARLQGFPDDFIFPGSKT--QLYKQIGNAVPVPVAEAIAK 320
dcm TIGR00675
DNA-methyltransferase (dcm); All proteins in this family for which functions are known are ...
6-387 4.37e-25

DNA-methyltransferase (dcm); All proteins in this family for which functions are known are DNA-cytosine methyltransferases. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 273211 [Multi-domain]  Cd Length: 315  Bit Score: 103.95  E-value: 4.37e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184      6 VLELYSGVGGMHHALRESCIpaQVVAAIDVNTVANEVYKYNFPHtQLLAKTIEGITLEEFDrlSFDMILMSPPCQPFTRI 85
Cdd:TIGR00675   1 FIDLFAGIGGIRLGFEQAGF--KCVFASEIDKYAQKTYEANFGN-KVPFGDITKISPSDIP--DFDILLGGFPCQPFSIA 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184     86 GRQGDMTDSRTNSFLHILDILPrlQKLPKYILLENVKGFeVSS----TRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRL 161
Cdd:TIGR00675  76 GKRKGFEDTRGTLFFEIVRILK--EKKPKFFLLENVKGL-VSHdkgrTFKVIIETLEELGYKVYYKVLNAKDFGVPQNRE 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    162 RYFLIA-KLQSEPLPFqapgqvlmEFPKiesvhPQKYAMDVENKiqeKNVEPNISFDGSIQCSgkdailfkletaeeiHR 240
Cdd:TIGR00675 153 RIYIVGfRDFDDKLNF--------EFPK-----PIYVAKKKRIG---DLLDLSVDLEEKYYLS---------------EE 201
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758184    241 KNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALlldivqptcrrsvcfTKGYGSYIEGTGSVLQTAEDVQVEniy 320
Cdd:TIGR00675 202 KKNGLLLLLENMRKKEGTGEQIGSFYNRESKSSIIRTL---------------SARGYTFVKGGKSVLIVPHKSTVV--- 263
                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4758184    321 ksltnlsQEEQITKLlilklryfTPKEIANLLGFPPEFGFPekITVKQRYRLLGNSLNVHVVAKLIK 387
Cdd:TIGR00675 264 -------HPGRIRRL--------TPRECARLQGFPDDFKFP--VSDSQLYKQAGNAVVVPVIEAIAK 313
PRK10458 PRK10458
DNA cytosine methylase; Provisional
341-387 2.69e-03

DNA cytosine methylase; Provisional


Pssm-ID: 236696 [Multi-domain]  Cd Length: 467  Bit Score: 39.66  E-value: 2.69e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|..
gi 4758184   341 RYFTPKEIANLLGFPPEFGFPEKITVK--QRYRLLGNSLNVHV---VAKLIK 387
Cdd:PRK10458 402 RRLTPRECARLMGFEAPGEAKFRIPVSdtQAYRQFGNSVVVPVfaaVAKLLE 453
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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