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Conserved domains on  [gi|16933540|ref|NP_004451|]
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prolyl endopeptidase FAP isoform 1 [Homo sapiens]

Protein Classification

S9 family peptidase( domain architecture ID 12012129)

peptidase S9 family protein, an oligopeptidase which may cleave the prolyl bond of short peptides, similar to oligopeptidase B, which cleaves on the C-terminal side of lysyl and argininyl residues

CATH:  3.40.50.1820|2.140.10.30
EC:  3.4.-.-
Gene Ontology:  GO:0008236|GO:0006508
MEROPS:  S9
PubMed:  19508187|12369917|35631755
SCOP:  3000102

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 106-473 6.32e-122

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


:

Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 369.34  E-value: 6.32e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   106 SPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITF 185
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   186 NGrENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQ-YPRTINIPYPKAGAKNPVVRI 264
Cdd:pfam00930  81 DG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGpGPEVREIKYPKAGAPNPTVEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   265 FIIDTTYPAYVgpqEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCpktqehiEESRT 344
Cdd:pfam00930 160 FVYDLASGKTV---EVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------EETSD 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   345 GWAggFFVSTPVFSY-DAISYYKIfSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRV--TQDSLFYSSNefEEYPGR 421
Cdd:pfam00930 230 GWV--ELHQDPHFIKrDGSGFLWI-SERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGVdeTRDLVYFTAT--EDSPTE 304

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16933540   422 RNIYRISIGSyPPSKKCVTCHLRKErcqYYTASFSDYAKYYALVCYGPGIPI 473
Cdd:pfam00930 305 RHLYSVSLDS-GGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
553-756 1.40e-64

Prolyl oligopeptidase family;


:

Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 214.02  E-value: 1.40e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   553 FAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSL 632
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   633 ALASGTGLFKCGIAVAPVSSWEYYAS----VYTERFMGLPTKDDNLEHYK-NSTVMARAEYFRNVDYLLIHGTADDNVHF 707
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDyLSPYSPADNVKVYPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 16933540   708 QNSAQIAKALVNAQVDFQAMWYSDQNHG-LSGLSTNHLYTHMTHFLKQCF 756
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGiGKPRNKVEEYARELAFLLEYL 210
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 106-473 6.32e-122

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 369.34  E-value: 6.32e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   106 SPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITF 185
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   186 NGrENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQ-YPRTINIPYPKAGAKNPVVRI 264
Cdd:pfam00930  81 DG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGpGPEVREIKYPKAGAPNPTVEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   265 FIIDTTYPAYVgpqEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCpktqehiEESRT 344
Cdd:pfam00930 160 FVYDLASGKTV---EVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------EETSD 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   345 GWAggFFVSTPVFSY-DAISYYKIfSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRV--TQDSLFYSSNefEEYPGR 421
Cdd:pfam00930 230 GWV--ELHQDPHFIKrDGSGFLWI-SERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGVdeTRDLVYFTAT--EDSPTE 304

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16933540   422 RNIYRISIGSyPPSKKCVTCHLRKErcqYYTASFSDYAKYYALVCYGPGIPI 473
Cdd:pfam00930 305 RHLYSVSLDS-GGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
553-756 1.40e-64

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 214.02  E-value: 1.40e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   553 FAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSL 632
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   633 ALASGTGLFKCGIAVAPVSSWEYYAS----VYTERFMGLPTKDDNLEHYK-NSTVMARAEYFRNVDYLLIHGTADDNVHF 707
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDyLSPYSPADNVKVYPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 16933540   708 QNSAQIAKALVNAQVDFQAMWYSDQNHG-LSGLSTNHLYTHMTHFLKQCF 756
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGiGKPRNKVEEYARELAFLLEYL 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
514-756 1.18e-52

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 182.52  E-value: 1.18e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 514 DEITLWYKMILPPQfdrSKKYPLLIQVYGGPCSQSVRSVFavnWISYLASKeGMVIALVDGRGtafQGDKLlyavyRKLG 593
Cdd:COG1506   6 DGTTLPGWLYLPAD---GKKYPVVVYVHGGPGSRDDSFLP---LAQALASR-GYAVLAPDYRG---YGESA-----GDWG 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 594 VYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASV---YTERFMGLPtk 670
Cdd:COG1506  71 GDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTERLMGGP-- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 671 DDNLEHYKNSTVMARAEYFRnVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTH 750
Cdd:COG1506 149 WEDPEAYAARSPLAYADKLK-TPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAGAPDYLERILD 227


                ....*.
gi 16933540 751 FLKQCF 756
Cdd:COG1506 228 FLDRHL 233
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 131-228 3.77e-06

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 47.36  E-value: 3.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 131 YIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYV----YQNNIYLKQRPGDPPFQITFNGRENkifngipdwvyeeeml 206
Cdd:COG0823  14 YVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTsdrgGGPQIYVVDADGGEPRRLTFGGGYN---------------- 77

                        90       100
                ....*....|....*....|..
gi 16933540 207 atkYALWWSPNGKFLAYAEFND 228
Cdd:COG0823  78 ---ASPSWSPDGKRLAFVSRSD 96
 
Name Accession Description Interval E-value
DPPIV_N pfam00930
Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region ...
 106-473 6.32e-122

Dipeptidyl peptidase IV (DPP IV) N-terminal region; This family is an alignment of the region to the N-terminal side of the active site. The Prosite motif does not correspond to this Pfam entry.


Pssm-ID: 395744 [Multi-domain]  Cd Length: 352  Bit Score: 369.34  E-value: 6.32e-122
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   106 SPDRQFVYLESDYSKLWRYSYTATYYIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYVYQNNIYLKQRPGDPPFQITF 185
Cdd:pfam00930   1 SPDGKYLLLATNYTKNWRHSYTADYYIYDLETNRVEPLPPGEGKIQDAKWSPDGDRLAFVRDNNLYVRELATGKEIQITS 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   186 NGrENKIFNGIPDWVYEEEMLATKYALWWSPNGKFLAYAEFNDTDIPVIAYSYYGDEQ-YPRTINIPYPKAGAKNPVVRI 264
Cdd:pfam00930  81 DG-SDGIFNGVADWVYEEEVLGSNSAVWWSPDGSRLAFLRFDESEVPIITLPYYTDEGpGPEVREIKYPKAGAPNPTVEL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   265 FIIDTTYPAYVgpqEVPVPAMIASSDYYFSWLTWVTDERVCLQWLKRVQNVSVLSICDFREDWQTWDCpktqehiEESRT 344
Cdd:pfam00930 160 FVYDLASGKTV---EVVPPDDLSDADYYITRVKWVPDGKLLVQWLNRDQNRLKVVLCDAETGRTVVIL-------EETSD 229

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   345 GWAggFFVSTPVFSY-DAISYYKIfSDKDGYKHIHYIKDTVENAIQITSGKWEAINIFRV--TQDSLFYSSNefEEYPGR 421
Cdd:pfam00930 230 GWV--ELHQDPHFIKrDGSGFLWI-SERDGYNHLYLYDLDGKSPIQLTSGNWEVTSILGVdeTRDLVYFTAT--EDSPTE 304

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 16933540   422 RNIYRISIGSyPPSKKCVTCHLRKErcqYYTASFSDYAKYYALVCYGPGIPI 473
Cdd:pfam00930 305 RHLYSVSLDS-GGEPTCLTDDSGDH---DYSASFSPNGSYYVLTYSGPDTPP 352
Peptidase_S9 pfam00326
Prolyl oligopeptidase family;
553-756 1.40e-64

Prolyl oligopeptidase family;


Pssm-ID: 459761 [Multi-domain]  Cd Length: 213  Bit Score: 214.02  E-value: 1.40e-64
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   553 FAVNWISYLASKEGMVIALVDGRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSL 632
Cdd:pfam00326   1 PSFSWNAQLLADRGYVVAIANGRGSGGYGEAFHDAGKGDLGQNEFDDFIAAAEYLIEQGYTDPDRLAIWGGSYGGYLTGA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   633 ALASGTGLFKCGIAVAPVSSWEYYAS----VYTERFMGLPTKDDNLEHYK-NSTVMARAEYFRNVDYLLIHGTADDNVHF 707
Cdd:pfam00326  81 ALNQRPDLFKAAVAHVPVVDWLAYMSdtslPFTERYMEWGNPWDNEEGYDyLSPYSPADNVKVYPPLLLIHGLLDDRVPP 160

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|
gi 16933540   708 QNSAQIAKALVNAQVDFQAMWYSDQNHG-LSGLSTNHLYTHMTHFLKQCF 756
Cdd:pfam00326 161 WQSLKLVAALQRKGVPFLLLIFPDEGHGiGKPRNKVEEYARELAFLLEYL 210
DAP2 COG1506
Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];
514-756 1.18e-52

Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism];


Pssm-ID: 441115 [Multi-domain]  Cd Length: 234  Bit Score: 182.52  E-value: 1.18e-52
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 514 DEITLWYKMILPPQfdrSKKYPLLIQVYGGPCSQSVRSVFavnWISYLASKeGMVIALVDGRGtafQGDKLlyavyRKLG 593
Cdd:COG1506   6 DGTTLPGWLYLPAD---GKKYPVVVYVHGGPGSRDDSFLP---LAQALASR-GYAVLAPDYRG---YGESA-----GDWG 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 594 VYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYYASV---YTERFMGLPtk 670
Cdd:COG1506  71 GDEVDDVLAAIDYLAARPYVDPDRIGIYGHSYGGYMALLAAARHPDRFKAAVALAGVSDLRSYYGTtreYTERLMGGP-- 148

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 671 DDNLEHYKNSTVMARAEYFRnVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLSTNHLYTHMTH 750
Cdd:COG1506 149 WEDPEAYAARSPLAYADKLK-TPLLLIHGEADDRVPPEQAERLYEALKKAGKPVELLVYPGEGHGFSGAGAPDYLERILD 227


                ....*.
gi 16933540 751 FLKQCF 756
Cdd:COG1506 228 FLDRHL 233
DLH COG0412
Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];
561-735 2.22e-07

Dienelactone hydrolase [Secondary metabolites biosynthesis, transport and catabolism];


Pssm-ID: 440181 [Multi-domain]  Cd Length: 226  Bit Score: 52.28  E-value: 2.22e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 561 LAsKEGMVIALVD--GRGTAFQGDKLLYAVYRKLGVYEVEDQITAVRKFI-EMGFIDEKRIAIWGWSYGGYVsSLALASG 637
Cdd:COG0412  52 LA-AAGYVVLAPDlyGRGGPGDDPDEARALMGALDPELLAADLRAALDWLkAQPEVDAGRVGVVGFCFGGGL-ALLAAAR 129

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 638 TGLFKCGIAvapvssweyyasvyterFMGLPTKDDNLEHYKNSTvmaraeyfrnVDYLLIHGTADDNVHFQNSAQIAKAL 717
Cdd:COG0412 130 GPDLAAAVS-----------------FYGGLPADDLLDLAARIK----------APVLLLYGEKDPLVPPEQVAALEAAL 182

                       170
                ....*....|....*...
gi 16933540 718 VNAQVDFQAMWYSDQNHG 735
Cdd:COG0412 183 AAAGVDVELHVYPGAGHG 200
FrsA COG1073
Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms]; ...
 514-716 2.58e-07

Fermentation-respiration switch esterase FrsA, DUF1100 family [Signal transduction mechanisms];


Pssm-ID: 440691 [Multi-domain]  Cd Length: 253  Bit Score: 52.61  E-value: 2.58e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 514 DEITL---WYkmiLPPqfDRSKKYPLLIQVYGGPCSQSVRSVFAvnwiSYLAsKEGMVIALVDGRGT-AFQGDkllyavY 589
Cdd:COG1073  19 DGIKLagdLY---LPA--GASKKYPAVVVAHGNGGVKEQRALYA----QRLA-ELGFNVLAFDYRGYgESEGE------P 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 590 RKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGlFKCGIAVAPVSSWEYYASVYTERFMGLPT 669
Cdd:COG1073  83 REEGSPERRDARAAVDYLRTLPGVDPERIGLLGISLGGGYALNAAATDPR-VKAVILDSPFTSLEDLAAQRAKEARGAYL 161

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*
gi 16933540 670 KDDNLeHYKNSTVMARAEYFRNVDY--------LLIHGTADDNVHFQNSAQIAKA 716
Cdd:COG1073 162 PGVPY-LPNVRLASLLNDEFDPLAKiekisrplLFIHGEKDEAVPFYMSEDLYEA 215
LpqC COG3509
Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and ...
 511-720 1.59e-06

Acetyl xylan esterase AxeA and related esterases, LpqC family [Carbohydrate transport and metabolism];


Pssm-ID: 442732 [Multi-domain]  Cd Length: 284  Bit Score: 50.39  E-value: 1.59e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 511 LEVDEITLWYKMILPPQFDRSKKYPLLIQVYGgpCSQSVRSVFAV-NWISyLASKEGMVIALVDGRGTA-------FQGD 582
Cdd:COG3509  30 FTVGGGTRTYRLYVPAGYDGGAPLPLVVALHG--CGGSAADFAAGtGLNA-LADREGFIVVYPEGTGRApgrcwnwFDGR 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 583 KllyavyRKLGVYEVEDQITAVRKFIEMGFIDEKRIAIWGWSYGGYVSSLALASGTGLFKcgiAVAPVSsweyyasvyte 662
Cdd:COG3509 107 D------QRRGRDDVAFIAALVDDLAARYGIDPKRVYVTGLSAGGAMAYRLACEYPDVFA---AVAPVA----------- 166

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 16933540 663 rfmGLPTKDDNlehyknstvMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNA 720
Cdd:COG3509 167 ---GLPYGAAS---------DAACAPGRPVPVLVIHGTADPTVPYAGAEETLAQWAAL 212
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 131-228 3.77e-06

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 47.36  E-value: 3.77e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 131 YIYDLSNGEFVRGNELPRPIQYLCWSPVGSKLAYV----YQNNIYLKQRPGDPPFQITFNGRENkifngipdwvyeeeml 206
Cdd:COG0823  14 YVVDLDGGEPRRLTNSPGIDTSPAWSPDGRRIAFTsdrgGGPQIYVVDADGGEPRRLTFGGGYN---------------- 77

                        90       100
                ....*....|....*....|..
gi 16933540 207 atkYALWWSPNGKFLAYAEFND 228
Cdd:COG0823  78 ---ASPSWSPDGKRLAFVSRSD 96
Aes COG0657
Acetyl esterase/lipase [Lipid transport and metabolism];
529-757 3.86e-05

Acetyl esterase/lipase [Lipid transport and metabolism];


Pssm-ID: 440422 [Multi-domain]  Cd Length: 207  Bit Score: 45.25  E-value: 3.86e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 529 DRSKKYPLLIQVYGG-PCSQSVRSVFAVnwISYLASKEGMVIALVDgrgtafqgdkllyavYRKL-------GVYEVEDQ 600
Cdd:COG0657   8 GAKGPLPVVVYFHGGgWVSGSKDTHDPL--ARRLAARAGAAVVSVD---------------YRLApehpfpaALEDAYAA 70

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 601 ITAVRKFIEMGFIDEKRIAIWGWSYGGY-VSSLALA---SGTGLFKCGIAVAPVSSWEyyASVYTERFMGL-PTkddnle 675
Cdd:COG0657  71 LRWLRANAAELGIDPDRIAVAGDSAGGHlAAALALRardRGGPRPAAQVLIYPVLDLT--ASPLRADLAGLpPT------ 142

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 676 hyknstvmaraeyfrnvdyLLIHGTADDNVhfQNSAQIAKALVNAQVDFQAMWYSDQNHGLSGLS----TNHLYTHMTHF 751
Cdd:COG0657 143 -------------------LIVTGEADPLV--DESEALAAALRAAGVPVELHVYPGGGHGFGLLAglpeARAALAEIAAF 201


                ....*.
gi 16933540 752 LKQCFS 757
Cdd:COG0657 202 LRRALA 207
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 68-224 8.85e-05

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 43.51  E-value: 8.85e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540  68 LHQSADNNIVLYNIETGQSYTILSNRTMKSVNAsnygLSPDRQFVYLESDYSKLWRYsytatyYIYDLSNGEFVRGNELP 147
Cdd:COG0823   5 LSRDGNSDIYVVDLDGGEPRRLTNSPGIDTSPA----WSPDGRRIAFTSDRGGGPQI------YVVDADGGEPRRLTFGG 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 148 RPIQYLCWSPVGSKLAYVYQNN----IYLKQRPGDPPFQITfngrenkifngipdwvyeeemlATKYALWWSPNGKFLAY 223
Cdd:COG0823  75 GYNASPSWSPDGKRLAFVSRSDgrfdIYVLDLDGGAPRRLT----------------------DGPGSPSWSPDGRRIVF 132


                .
gi 16933540 224 A 224
Cdd:COG0823 133 S 133
YpfH COG0400
Predicted esterase [General function prediction only];
586-737 9.56e-05

Predicted esterase [General function prediction only];


Pssm-ID: 440169 [Multi-domain]  Cd Length: 200  Bit Score: 44.13  E-value: 9.56e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 586 YAVYRKLGVYEVEDQITAVRKFIEmgFIDE---------KRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPvssweyy 656
Cdd:COG0400  52 FDLSFLEGREDEEGLAAAAEALAA--FIDElearygidpERIVLAGFSQGAAMALSLALRRPELLAGVVALSG------- 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 657 asvyterfmGLPTKDDnlehyknstVMARAEYFRNVDYLLIHGTADDNVHFQNSAQIAKALVNAQVDFQAMWYsDQNHGL 736
Cdd:COG0400 123 ---------YLPGEEA---------LPAPEAALAGTPVFLAHGTQDPVIPVERAREAAEALEAAGADVTYREY-PGGHEI 183


                .
gi 16933540 737 S 737
Cdd:COG0400 184 S 184
Peptidase_S15 pfam02129
X-Pro dipeptidyl-peptidase (S15 family);
529-656 1.69e-04

X-Pro dipeptidyl-peptidase (S15 family);


Pssm-ID: 396621 [Multi-domain]  Cd Length: 264  Bit Score: 44.25  E-value: 1.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540   529 DRSKKYPLL--IQVYGGPCSQSVRSVFAVNWISYLASkeGMVIALVDGRGTAFQGdkllyavyrklGVYEVE--DQITAV 604
Cdd:pfam02129  14 KTGGPVPALltRSPYGARRDGASDLALAHPEWEFAAR--GYAVVYQDVRGTGGSE-----------GVFTVGgpQEAADG 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 16933540   605 RKFIEmgFIDEK-----RIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVSSWEYY 656
Cdd:pfam02129  81 KDVID--WLAGQpwcngKVGMTGISYLGTTQLAAAATGPPGLKAIAPESGISDLYDY 135
Fes COG2382
Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];
524-725 7.58e-04

Enterochelin esterase or related enzyme [Inorganic ion transport and metabolism];


Pssm-ID: 441948 [Multi-domain]  Cd Length: 314  Bit Score: 42.53  E-value: 7.58e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 524 LPPQFD-RSKKYPLLIQVYGGPCSQS--VRSVFAVNWI-SYLASKEG--MVIALVDGRGTAFQGdkllyAVYRKLGVYE- 596
Cdd:COG2382 101 LPPGYDnPGKKYPVLYLLDGGGGDEQdwFDQGRLPTILdNLIAAGKIppMIVVMPDGGDGGDRG-----TEGPGNDAFEr 175

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 597 --VEDQITAVRKfiEMGFIDE-KRIAIWGWSYGGYVSSLALASGTGLFKcgiAVAPVSSweyyasvyterfmGLPTKDDN 673
Cdd:COG2382 176 flAEELIPFVEK--NYRVSADpEHRAIAGLSMGGLAALYAALRHPDLFG---YVGSFSG-------------SFWWPPGD 237

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|..
gi 16933540 674 LEHYKNSTVMARAEYFRNVDYLLIHGTADDNVhfQNSAQIAKALVNAQVDFQ 725
Cdd:COG2382 238 ADRGGWAELLAAGAPKKPLRFYLDVGTEDDLL--EANRALAAALKAKGYDVE 287
MenH COG0596
2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, ...
 595-722 2.81e-03

2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold [Coenzyme transport and metabolism, General function prediction only]; 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase MenH and related esterases, alpha/beta hydrolase fold is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440361 [Multi-domain]  Cd Length: 221  Bit Score: 39.98  E-value: 2.81e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 16933540 595 YEVEDQITAVRKFIEmgFIDEKRIAIWGWSYGGYVSSLALASGTGLFKCGIAVAPVssWEYYASVYTERFMGLPTKDDNL 674
Cdd:COG0596  70 YTLDDLADDLAALLD--ALGLERVVLVGHSMGGMVALELAARHPERVAGLVLVDEV--LAALAEPLRRPGLAPEALAALL 145

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 16933540 675 EHYKNSTVMARAEYFRnVDYLLIHGTADDNVHFQNSAQIAKALVNAQV 722
Cdd:COG0596 146 RALARTDLRERLARIT-VPTLVIWGEKDPIVPPALARRLAELLPNAEL 192
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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