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Conserved domains on  [gi|4758770|ref|NP_004532|]
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NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 [Homo sapiens]

Protein Classification

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1( domain architecture ID 11239517)

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I); believed not to be involved in catalysis

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MWFE pfam15879
NADH-ubiquinone oxidoreductase MWFE subunit; MWFE is a short subunit of NADH-ubiquinone ...
 2-56 6.74e-23

NADH-ubiquinone oxidoreductase MWFE subunit; MWFE is a short subunit of NADH-ubiquinone oxidoreductase found in eukaryotes. It is necessary for the activity of NADH-ubiquinone oxidoreductase complex I in mitochondria. This subunit is essential for the assembly and function of the enzyme. MWFE is found to be phosphorylated, eg in rat heart mitochondria. The short family includes much of a signal peptide.


:

Pssm-ID: 464920  Cd Length: 55  Bit Score: 81.82  E-value: 6.74e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 4758770     2 WFEILPGLSVMGVCLLIPGLATAYIHRFTNGGKEKRVAHFGYHWSLMERDRRISG 56
Cdd:pfam15879  1 WFEALPPFGIITVMFGVPGYGLAAIHKLQNGGKPRRYNLDQWDRQMMERDRRLTG 55
 
Name Accession Description Interval E-value
MWFE pfam15879
NADH-ubiquinone oxidoreductase MWFE subunit; MWFE is a short subunit of NADH-ubiquinone ...
 2-56 6.74e-23

NADH-ubiquinone oxidoreductase MWFE subunit; MWFE is a short subunit of NADH-ubiquinone oxidoreductase found in eukaryotes. It is necessary for the activity of NADH-ubiquinone oxidoreductase complex I in mitochondria. This subunit is essential for the assembly and function of the enzyme. MWFE is found to be phosphorylated, eg in rat heart mitochondria. The short family includes much of a signal peptide.


Pssm-ID: 464920  Cd Length: 55  Bit Score: 81.82  E-value: 6.74e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 4758770     2 WFEILPGLSVMGVCLLIPGLATAYIHRFTNGGKEKRVAHFGYHWSLMERDRRISG 56
Cdd:pfam15879  1 WFEALPPFGIITVMFGVPGYGLAAIHKLQNGGKPRRYNLDQWDRQMMERDRRLTG 55
 
Name Accession Description Interval E-value
MWFE pfam15879
NADH-ubiquinone oxidoreductase MWFE subunit; MWFE is a short subunit of NADH-ubiquinone ...
 2-56 6.74e-23

NADH-ubiquinone oxidoreductase MWFE subunit; MWFE is a short subunit of NADH-ubiquinone oxidoreductase found in eukaryotes. It is necessary for the activity of NADH-ubiquinone oxidoreductase complex I in mitochondria. This subunit is essential for the assembly and function of the enzyme. MWFE is found to be phosphorylated, eg in rat heart mitochondria. The short family includes much of a signal peptide.


Pssm-ID: 464920  Cd Length: 55  Bit Score: 81.82  E-value: 6.74e-23
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 4758770     2 WFEILPGLSVMGVCLLIPGLATAYIHRFTNGGKEKRVAHFGYHWSLMERDRRISG 56
Cdd:pfam15879  1 WFEALPPFGIITVMFGVPGYGLAAIHKLQNGGKPRRYNLDQWDRQMMERDRRLTG 55
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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