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Conserved domains on  [gi|4758804|ref|NP_004546|]
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nuclear factor of activated T-cells, cytoplasmic 3 isoform 2 [Homo sapiens]

Protein Classification

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List of domain hits

 Name Accession Description Interval E-value
RHD-n_NFAT cd07881
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
 421-594 7.56e-127

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development.


:

Pssm-ID: 143641  Cd Length: 175  Bit Score: 383.39  E-value: 7.56e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   421 DWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNE-KPINLQMFIGTADDRYLRPHAFYQVH 499
Cdd:cd07881    1 DWPLPSQSGQYELRIEVQPKPHHRAHYETEGSRGAVKASTGGHPVVQLHGYMEnKPLTLQMFIGTADDRYLRPHAFYQVH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   500 RITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKV 579
Cdd:cd07881   81 RITGKTVATASQEIIISNTKVLEIPLLPENNMRASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGRV 160

                        170
                 ....*....|....*
gi 4758804   580 LSLQIASIPVECSQR 594
Cdd:cd07881  161 LSLQVASNPIECSQR 175
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 599-699 2.44e-57

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


:

Pssm-ID: 238583  Cd Length: 101  Bit Score: 192.31  E-value: 2.44e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   599 LPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQV 678
Cdd:cd01178    1 LPEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGQDGEAQWEAEATIDKEKSHQNHLVVEVPPYHNKHVAAPVQV 80

                         90       100
                 ....*....|....*....|.
gi 4758804   679 HFYLCNGKRKKSQSQRFTYTP 699
Cdd:cd01178   81 QFYVVNGKRKRSQPQTFTYTP 101
KLF6_7_N-like super family cl41732
N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins; This subfamily ...
 237-308 9.98e-03

N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 6, KLF7, and similar proteins, including KLF Luna, a Drosophila KLF6/KLF7. KLF6 contributes to cell proliferation, differentiation, cell death and signal transduction. Hepatocyte expression of KLF6 regulates hepatic fatty acid and glucose metabolism via transcriptional activation of liver glucokinase and post-transcriptional regulation of the nuclear receptor peroxisome proliferator activated receptor alpha (PPARa). KLF7 is involved in regulation of the development and function of the nervous system and adipose tissue, type 2 diabetes, blood diseases, as well as pluripotent cell maintenance. KLF Luna is maternally required for synchronized nuclear and centrosome cycles in the preblastoderm embryo. KLF6 and KLF7 are transcriptional activators. They belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF6, KLF7, and similar proteins.


The actual alignment was detected with superfamily member cd21973:

Pssm-ID: 425363 [Multi-domain]  Cd Length: 138  Bit Score: 37.64  E-value: 9.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   237 PRQSPCHSPRSSVTDENWLSPRPASGPSSRPTSPCGKRR-----------HSSAEVCYAGSLSPHHSPVPSPGHSPRGSV 305
Cdd:cd21973   46 PKLTSYKKDPSDSPWSPWDLFTPPSEESESSDSDLSLLSiddllldvsslSSSSSSSSGVSWTPPSSPESSRSHPSSSYT 125


                 ...
gi 4758804   306 TED 308
Cdd:cd21973  126 KSS 128
 
Name Accession Description Interval E-value
RHD-n_NFAT cd07881
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
 421-594 7.56e-127

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development.


Pssm-ID: 143641  Cd Length: 175  Bit Score: 383.39  E-value: 7.56e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   421 DWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNE-KPINLQMFIGTADDRYLRPHAFYQVH 499
Cdd:cd07881    1 DWPLPSQSGQYELRIEVQPKPHHRAHYETEGSRGAVKASTGGHPVVQLHGYMEnKPLTLQMFIGTADDRYLRPHAFYQVH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   500 RITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKV 579
Cdd:cd07881   81 RITGKTVATASQEIIISNTKVLEIPLLPENNMRASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGRV 160

                        170
                 ....*....|....*
gi 4758804   580 LSLQIASIPVECSQR 594
Cdd:cd07881  161 LSLQVASNPIECSQR 175
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 599-699 2.44e-57

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 192.31  E-value: 2.44e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   599 LPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQV 678
Cdd:cd01178    1 LPEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGQDGEAQWEAEATIDKEKSHQNHLVVEVPPYHNKHVAAPVQV 80

                         90       100
                 ....*....|....*....|.
gi 4758804   679 HFYLCNGKRKKSQSQRFTYTP 699
Cdd:cd01178   81 QFYVVNGKRKRSQPQTFTYTP 101
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
 602-699 5.31e-33

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 465045  Cd Length: 102  Bit Score: 123.06  E-value: 5.31e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804     602 IEKYSINSCSVNGGHEMVVTGSNFLPE-SKIIFLEKGqDGRPQWEVEGKIIREKC-QGAHIVLEVPPYHNPAVTAAVQVH 679
Cdd:pfam16179    2 ICRLSLCSGSVTGGEEIILLCEKVLKDdIKVRFYEED-DGQEVWEAEGDFSKTDVhRQVAIVFKTPPYRDPDITEPVTVN 80

                           90       100
                   ....*....|....*....|.
gi 4758804     680 FYLCNGKRKK-SQSQRFTYTP 699
Cdd:pfam16179   81 IQLRRPSDKAtSEPQPFTYLP 101
RHD_DNA_bind pfam00554
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ...
 433-592 5.96e-31

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.


Pssm-ID: 425749  Cd Length: 169  Bit Score: 119.72  E-value: 5.96e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804     433 LKIEVQPKTH-HRAHYETEG-SRGAVKA-----STGGHPVVKLLGYNEKPInLQMFIGTADDRYlRPHAfyqvHRITGKT 505
Cdd:pfam00554    1 LEIVEQPKQRgMRFRYKCEGrSAGSIPGesstrSKKTFPTVQICNYDGPAV-IRVSLVTKDEPH-RPHP----HSLVGKD 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804     506 vatasqeiiiASTKVLEIPLLPENnMSASIDCAGILKLRNSDIELRKGE---TDIGRKN--------------TRVRLVF 568
Cdd:pfam00554   75 ----------CKDGVCEVELGPED-MVASFQNLGIQCVKKKDVEEALKErieLNIDPFNvgfealrqikdmdlNVVRLCF 143

                          170       180
                   ....*....|....*....|....*.
gi 4758804     569 RVHIPQPSG--KVLSLQIASIPVECS 592
Cdd:pfam00554  144 QAFLPDTRGnfTTPLPPVVSNPIYDK 169
IPT smart00429
ig-like, plexins, transcription factors;
599-698 4.14e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 65.90  E-value: 4.14e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804      599 LPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGqdgrpqWEVEGKIIREKcqGAHIVLEVPPYHNPAVTAAVQv 678
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGV------GEAPCTFSPSS--STAIVCKTPPYHNIPGSVPVR- 71

                            90       100
                    ....*....|....*....|
gi 4758804      679 HFYLCNGKRkKSQSQRFTYT 698
Cdd:smart00429   72 TVGLRNGGV-PSSPQPFTYV 90
KLF6_7_N-like cd21973
N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins; This subfamily ...
 237-308 9.98e-03

N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 6, KLF7, and similar proteins, including KLF Luna, a Drosophila KLF6/KLF7. KLF6 contributes to cell proliferation, differentiation, cell death and signal transduction. Hepatocyte expression of KLF6 regulates hepatic fatty acid and glucose metabolism via transcriptional activation of liver glucokinase and post-transcriptional regulation of the nuclear receptor peroxisome proliferator activated receptor alpha (PPARa). KLF7 is involved in regulation of the development and function of the nervous system and adipose tissue, type 2 diabetes, blood diseases, as well as pluripotent cell maintenance. KLF Luna is maternally required for synchronized nuclear and centrosome cycles in the preblastoderm embryo. KLF6 and KLF7 are transcriptional activators. They belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF6, KLF7, and similar proteins.


Pssm-ID: 409246 [Multi-domain]  Cd Length: 138  Bit Score: 37.64  E-value: 9.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   237 PRQSPCHSPRSSVTDENWLSPRPASGPSSRPTSPCGKRR-----------HSSAEVCYAGSLSPHHSPVPSPGHSPRGSV 305
Cdd:cd21973   46 PKLTSYKKDPSDSPWSPWDLFTPPSEESESSDSDLSLLSiddllldvsslSSSSSSSSGVSWTPPSSPESSRSHPSSSYT 125


                 ...
gi 4758804   306 TED 308
Cdd:cd21973  126 KSS 128
 
Name Accession Description Interval E-value
RHD-n_NFAT cd07881
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
 421-594 7.56e-127

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development.


Pssm-ID: 143641  Cd Length: 175  Bit Score: 383.39  E-value: 7.56e-127
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   421 DWPLPAHFGQCELKIEVQPKTHHRAHYETEGSRGAVKASTGGHPVVKLLGYNE-KPINLQMFIGTADDRYLRPHAFYQVH 499
Cdd:cd07881    1 DWPLPSQSGQYELRIEVQPKPHHRAHYETEGSRGAVKASTGGHPVVQLHGYMEnKPLTLQMFIGTADDRYLRPHAFYQVH 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   500 RITGKTVATASQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKV 579
Cdd:cd07881   81 RITGKTVATASQEIIISNTKVLEIPLLPENNMRASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGRV 160

                        170
                 ....*....|....*
gi 4758804   580 LSLQIASIPVECSQR 594
Cdd:cd07881  161 LSLQVASNPIECSQR 175
RHD-n_NFAT_like cd07927
N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells ...
 432-593 1.86e-69

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of activated T-cells (NFAT) proteins and similar proteins; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes that are mainly involved in cell-cell interaction. Upon de-phosphorylation of the nuclear localization signal, NFAT enters the nucleus and acts as a transcription factor; its export from the nucleus is triggered by phosphorylation via export kinases. NFATs play important roles in mediating the immune response, and are found in T cells, B Cells, NK cells, mast cells, and monocytes. NFATs are also found in various non-hematopoietic cell types, where they play roles in development. This group also contains the N-terminal RHD sub-domain of the non-calcium regulated tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.


Pssm-ID: 143648  Cd Length: 161  Bit Score: 229.08  E-value: 1.86e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   432 ELKIEVQPKTHHRAHYETEGSRGAVKA-STGGHPVVKLLGYNEkPINLQMFIGTADDRyLRPHAFYQVHRITGKTvATAS 510
Cdd:cd07927    2 ELRIEVQPEPHHRARYETEGSRGAVKApSTGGFPTVKLHGYME-PVGLQVFIGTASGR-LKPHAFYQVHRITGKT-TTPC 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   511 QEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPVE 590
Cdd:cd07927   79 KEKIIGNTKVLEIPLEPKNNMTATIDCAGILKLRNADIELRKGETDIKKKNTRARLVFRVHIPEKDGRIVSLQTASNPIE 158


                 ...
gi 4758804   591 CSQ 593
Cdd:cd07927  159 CSQ 161
RHD-n_TonEBP cd07882
N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding ...
 431-593 5.46e-60

N-terminal sub-domain of the Rel homology domain (RHD) of tonicity-responsive enhancer binding protein (TonEBP); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the tonicity-responsive enhancer binding protein (TonEBP), also called NFAT5. Mammalian TonEBP regulates the expression of genes in response to tonicity. It plays a pivotal role in urinary concentrating mechanisms in kidney medulla, by triggering the accumulation of osmolytes that enable renal medullary cells to tolerate high levels of urea and salt.


Pssm-ID: 143642  Cd Length: 161  Bit Score: 202.36  E-value: 5.46e-60
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   431 CELKIEVQPKTHHRAHYETEGSRGAVKASTG-GHPVVKLLGYNeKPINLQMFIGTADDRyLRPHAFYQVHRITGKTvATA 509
Cdd:cd07882    1 KELKILVQPETQHRARYLTEGSRGSVKDRSQqGFPTVKLEGYN-KPVVLQVFVGTDSGR-VKPHGFYQACKVTGRN-TTP 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   510 SQEIIIASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETDIGRKNTRVRLVFRVHIPQPSGKVLSLQIASIPV 589
Cdd:cd07882   78 CEEVDVEGTTVIEVPLDPTNNMTISVDCVGILKLRNADVEARIGIARSKKKSTRVRLVFRVIIPRKDGSTLTLQTVSNPI 157


                 ....
gi 4758804   590 ECSQ 593
Cdd:cd07882  158 LCTQ 161
IPT_NFAT cd01178
IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a ...
 599-699 2.44e-57

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.


Pssm-ID: 238583  Cd Length: 101  Bit Score: 192.31  E-value: 2.44e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   599 LPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGQDGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQV 678
Cdd:cd01178    1 LPEIEKKSLNSCSVNGGEELFLTGKNFLKDSKVVFQEKGQDGEAQWEAEATIDKEKSHQNHLVVEVPPYHNKHVAAPVQV 80

                         90       100
                 ....*....|....*....|.
gi 4758804   679 HFYLCNGKRKKSQSQRFTYTP 699
Cdd:cd01178   81 QFYVVNGKRKRSQPQTFTYTP 101
IPT_TF cd00602
IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated ...
 600-699 4.63e-36

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.


Pssm-ID: 238336  Cd Length: 101  Bit Score: 131.64  E-value: 4.63e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   600 PHIEKYSINSCSVNGGHEMVVTGSNFL-PESKIIFLEKGQdGRPQWEVEGKIIREKCQGAHIVLEVPPYHNPAVTAAVQV 678
Cdd:cd00602    1 LPICRVSSLSGSVNGGDEVFLLCDKVNkPDIKVWFGEKGP-GETVWEAEAMFRQEDVRQVAIVFKTPPYHNKWITRPVQV 79

                         90       100
                 ....*....|....*....|..
gi 4758804   679 HFYLCNG-KRKKSQSQRFTYTP 699
Cdd:cd00602   80 PIQLVRPdDRKRSEPLTFTYTP 101
RHD-n cd07827
N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology ...
 432-593 1.52e-35

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).


Pssm-ID: 143640  Cd Length: 174  Bit Score: 132.88  E-value: 1.52e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   432 ELKIEVQPKTH-HRAHYETEG-SRGAVK-----ASTGGHPVVKLLGYNEkPINLQMFIGTADDRYlRPHAfYQVHRITGk 504
Cdd:cd07827    2 YLEITEQPKQRgHRFRYECEGrSAGSIPgenstADRKTFPTVKLRNYNG-PAKIVVSLVTKDDPP-KPHP-HQLVGKTD- 77

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   505 tvatasqeiiiASTKVLEIPLLPENNMSASIDCAGILKLRNSDIELRKGETD-----------------IGRKNTRVRLV 567
Cdd:cd07827   78 -----------CRDGVCEVRLGPKNNMTASFNNLGIQCVRKKDVEEALGQRIqlgidpfmvhkgpegnaSDIDLNRVRLC 146

                        170       180
                 ....*....|....*....|....*...
gi 4758804   568 FRVHIPQPSGK--VLSLQIASIPVECSQ 593
Cdd:cd07827  147 FQAFIEDSDGGftLPLPPVLSNPIYDKK 174
RHD_dimer pfam16179
Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural ...
 602-699 5.31e-33

Rel homology dimerization domain; The Rel homology domain (RHD) is composed of two structural domains, an N-terminal DNA_binding domain (pfam00554) and a C-terminal dimerization domain. This is the dimerization domain.


Pssm-ID: 465045  Cd Length: 102  Bit Score: 123.06  E-value: 5.31e-33
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804     602 IEKYSINSCSVNGGHEMVVTGSNFLPE-SKIIFLEKGqDGRPQWEVEGKIIREKC-QGAHIVLEVPPYHNPAVTAAVQVH 679
Cdd:pfam16179    2 ICRLSLCSGSVTGGEEIILLCEKVLKDdIKVRFYEED-DGQEVWEAEGDFSKTDVhRQVAIVFKTPPYRDPDITEPVTVN 80

                           90       100
                   ....*....|....*....|.
gi 4758804     680 FYLCNGKRKK-SQSQRFTYTP 699
Cdd:pfam16179   81 IQLRRPSDKAtSEPQPFTYLP 101
RHD_DNA_bind pfam00554
Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are ...
 433-592 5.96e-31

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.


Pssm-ID: 425749  Cd Length: 169  Bit Score: 119.72  E-value: 5.96e-31
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804     433 LKIEVQPKTH-HRAHYETEG-SRGAVKA-----STGGHPVVKLLGYNEKPInLQMFIGTADDRYlRPHAfyqvHRITGKT 505
Cdd:pfam00554    1 LEIVEQPKQRgMRFRYKCEGrSAGSIPGesstrSKKTFPTVQICNYDGPAV-IRVSLVTKDEPH-RPHP----HSLVGKD 74

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804     506 vatasqeiiiASTKVLEIPLLPENnMSASIDCAGILKLRNSDIELRKGE---TDIGRKN--------------TRVRLVF 568
Cdd:pfam00554   75 ----------CKDGVCEVELGPED-MVASFQNLGIQCVKKKDVEEALKErieLNIDPFNvgfealrqikdmdlNVVRLCF 143

                          170       180
                   ....*....|....*....|....*.
gi 4758804     569 RVHIPQPSG--KVLSLQIASIPVECS 592
Cdd:pfam00554  144 QAFLPDTRGnfTTPLPPVVSNPIYDK 169
IPT smart00429
ig-like, plexins, transcription factors;
599-698 4.14e-13

ig-like, plexins, transcription factors;


Pssm-ID: 214657 [Multi-domain]  Cd Length: 90  Bit Score: 65.90  E-value: 4.14e-13
                            10        20        30        40        50        60        70        80
                    ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804      599 LPHIEKYSINSCSVNGGHEMVVTGSNFLPESKIIFLEKGqdgrpqWEVEGKIIREKcqGAHIVLEVPPYHNPAVTAAVQv 678
Cdd:smart00429    1 DPVITRISPTSGPVSGGTEITLCGKNLKSISVVFVEVGV------GEAPCTFSPSS--STAIVCKTPPYHNIPGSVPVR- 71

                            90       100
                    ....*....|....*....|
gi 4758804      679 HFYLCNGKRkKSQSQRFTYT 698
Cdd:smart00429   72 TVGLRNGGV-PSSPQPFTYV 90
IPT cd00102
Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as ...
 600-699 4.65e-09

Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor receptors), as well as, cyclodextrin glycosyltransferase and similar enzymes. Although they are involved in DNA binding in transcription factors, their function in other proteins is unknown. In these transcription factors, IPTs form homo- or heterodimers with the exception of the nuclear factor of activated Tcells (NFAT) transcription factors which are mainly monomers.


Pssm-ID: 238050 [Multi-domain]  Cd Length: 89  Bit Score: 54.39  E-value: 4.65e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   600 PHIEKYSINSCSVNGGHEMVVTGSNFLPES--KIIFLekgqdgrpqweVEGKIIREKCQGAHIVLEVPPYHNPavtAAVQ 677
Cdd:cd00102    1 PVITSISPSSGPVSGGTEVTITGSNFGSGSnlRVTFG-----------GGVPCSVLSVSSTAIVCTTPPYANP---GPGP 66

                         90       100
                 ....*....|....*....|...
gi 4758804   678 VHFYLCN-GKRKKSQSQRFTYTP 699
Cdd:cd00102   67 VEVTVDRgNGGITSSPLTFTYVP 89
KLF6_7_N-like cd21973
N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins; This subfamily ...
 237-308 9.98e-03

N-terminal domain of Kruppel-like factor (KLF) 6, KLF7, and similar proteins; This subfamily is composed of Kruppel-like factor or Krueppel-like factor (KLF) 6, KLF7, and similar proteins, including KLF Luna, a Drosophila KLF6/KLF7. KLF6 contributes to cell proliferation, differentiation, cell death and signal transduction. Hepatocyte expression of KLF6 regulates hepatic fatty acid and glucose metabolism via transcriptional activation of liver glucokinase and post-transcriptional regulation of the nuclear receptor peroxisome proliferator activated receptor alpha (PPARa). KLF7 is involved in regulation of the development and function of the nervous system and adipose tissue, type 2 diabetes, blood diseases, as well as pluripotent cell maintenance. KLF Luna is maternally required for synchronized nuclear and centrosome cycles in the preblastoderm embryo. KLF6 and KLF7 are transcriptional activators. They belong to a family of proteins, called the Specificity Protein (SP)/KLF family, characterized by a C-terminal DNA-binding domain of 81 amino acids consisting of three Kruppel-like C2H2 zinc fingers. These factors bind to a loose consensus motif, namely NNRCRCCYY (where N is any nucleotide; R is A/G, and Y is C/T), such as the recurring motifs in GC and GT boxes (5'-GGGGCGGGG-3' and 5-GGTGTGGGG-3') that are present in promoters and more distal regulatory elements of mammalian genes. Members of the KLF family can act as activators or repressors of transcription depending on cell and promoter context. KLFs regulate various cellular functions, such as proliferation, differentiation, and apoptosis, as well as the development and homeostasis of several types of tissue. In addition to the C-terminal DNA-binding domain, each KLF also has a unique N-terminal activation/repression domain that confers specificity and allows it to bind specifically to a certain partner, leading to distinct activities in vivo. This model represents the related N-terminal domains of KLF6, KLF7, and similar proteins.


Pssm-ID: 409246 [Multi-domain]  Cd Length: 138  Bit Score: 37.64  E-value: 9.98e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758804   237 PRQSPCHSPRSSVTDENWLSPRPASGPSSRPTSPCGKRR-----------HSSAEVCYAGSLSPHHSPVPSPGHSPRGSV 305
Cdd:cd21973   46 PKLTSYKKDPSDSPWSPWDLFTPPSEESESSDSDLSLLSiddllldvsslSSSSSSSSGVSWTPPSSPESSRSHPSSSYT 125


                 ...
gi 4758804   306 TED 308
Cdd:cd21973  126 KSS 128
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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