NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4758826|ref|NP_004549|]
View 

neurturin preproprotein [Homo sapiens]

Protein Classification

TGF-beta family protein( domain architecture ID 14443715)

transforming growth factor-beta (TGF-beta) family protein may control proliferation, differentiation, and other functions in many cell types

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TGF_beta_Neurturin cd19383
transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; ...
 103-197 5.03e-44

transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; Neurturin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that supports the survival of sympathetic neurons in culture and may regulate the development and maintenance of the CNS. It might control the size of non-neuronal cell population such as haemopoietic cells.


:

Pssm-ID: 381653  Cd Length: 104  Bit Score: 142.14  E-value: 5.03e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758826  103 CGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRL---RRERVRAQPCCRPTAYEDEVSFLDA 179
Cdd:cd19383   7 CSLRELEVTVSELGLGYESDETVLFRYCSGKCEAARRNYDLTLKHMRGKKSLkkgRKDKVRARPCCRPTAYEDDVSFLDN 86

                        90
                ....*....|....*...
gi 4758826  180 HSRYHTVHELSARECACV 197
Cdd:cd19383  87 NNRYHTIQELSAKECGCV 104
 
Name Accession Description Interval E-value
TGF_beta_Neurturin cd19383
transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; ...
 103-197 5.03e-44

transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; Neurturin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that supports the survival of sympathetic neurons in culture and may regulate the development and maintenance of the CNS. It might control the size of non-neuronal cell population such as haemopoietic cells.


Pssm-ID: 381653  Cd Length: 104  Bit Score: 142.14  E-value: 5.03e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758826  103 CGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRL---RRERVRAQPCCRPTAYEDEVSFLDA 179
Cdd:cd19383   7 CSLRELEVTVSELGLGYESDETVLFRYCSGKCEAARRNYDLTLKHMRGKKSLkkgRKDKVRARPCCRPTAYEDDVSFLDN 86

                        90
                ....*....|....*...
gi 4758826  180 HSRYHTVHELSARECACV 197
Cdd:cd19383  87 NNRYHTIQELSAKECGCV 104
TGF_beta pfam00019
Transforming growth factor beta like domain;
103-196 1.80e-10

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 55.41  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758826    103 CGLRELEVRVSELGLG--YASDETVLFRYCAGACEAAARVYDLGL--RRLRQRRRLRRERVRAQPCCRPTAYEDeVSFLD 178
Cdd:pfam00019   2 CRRHSLYVDFEDLGWDdwIIAPKGYNAYYCSGSCPSHLNPQLSATnhAILQSLLHSLKPANVPKPCCVPTKLSP-LSVLY 80

                          90       100
                  ....*....|....*....|..
gi 4758826    179 AHS----RYHTVHELSARECAC 196
Cdd:pfam00019  81 YDDegnvVLKTYPDMVVESCGC 102
 
Name Accession Description Interval E-value
TGF_beta_Neurturin cd19383
transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; ...
 103-197 5.03e-44

transforming growth factor beta (TGF-beta) like domain found in Neurturin and similar proteins; Neurturin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that supports the survival of sympathetic neurons in culture and may regulate the development and maintenance of the CNS. It might control the size of non-neuronal cell population such as haemopoietic cells.


Pssm-ID: 381653  Cd Length: 104  Bit Score: 142.14  E-value: 5.03e-44
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758826  103 CGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRL---RRERVRAQPCCRPTAYEDEVSFLDA 179
Cdd:cd19383   7 CSLRELEVTVSELGLGYESDETVLFRYCSGKCEAARRNYDLTLKHMRGKKSLkkgRKDKVRARPCCRPTAYEDDVSFLDN 86

                        90
                ....*....|....*...
gi 4758826  180 HSRYHTVHELSARECACV 197
Cdd:cd19383  87 NNRYHTIQELSAKECGCV 104
TGF_beta_GDNF_like cd13750
transforming growth factor beta (TGF-beta) like domain found in the glial cell-line-derived ...
 103-196 9.05e-37

transforming growth factor beta (TGF-beta) like domain found in the glial cell-line-derived neurotrophic factor (GDNF) family of ligands; GDNF family of ligands includes GDNF, Artemin, Neurturin, and Persephin. They plays an important role in the development and maintenance of the central and peripheral nervous system, renal morphogenesis, and spermatogenesis.


Pssm-ID: 381628  Cd Length: 95  Bit Score: 123.33  E-value: 9.05e-37
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758826  103 CGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAHSR 182
Cdd:cd13750   2 CVLRELHLRVTDLGLGYASEEEVIFRYCAGSCEAARTNYDLILANLRGWRRLRSDRKVGQPCCRPTAYDDDVSFLDDNSR 81

                        90
                ....*....|....
gi 4758826  183 YHTVHELSARECAC 196
Cdd:cd13750  82 YHILRKLSAKACGC 95
TGF_beta_Artemin cd19381
transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; ...
 103-197 2.96e-28

transforming growth factor beta (TGF-beta) like domain found in Artemin and similar proteins; Artemin, also termed Enovin, or Neublastin, is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with growth promoting activity on neuronal cells. It acts as the ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. It supports peripheral and central neurons and signals through the GFR-alpha-3-RET receptor complex.


Pssm-ID: 381651  Cd Length: 98  Bit Score: 101.66  E-value: 2.96e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758826  103 CGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYDLGLRR---LRQRRRLRRERVRAQPCCRPTAYEDeVSFLDA 179
Cdd:cd19381   2 CRLRSLRVKVRDLGLGYESDEIVLFKYCSGSCQRARTNYDLTLNSllkQGAIPPGPHERVSSQPCCRPTRYEN-VSFMDV 80

                        90
                ....*....|....*...
gi 4758826  180 HSRYHTVHELSARECACV 197
Cdd:cd19381  81 QNVWQTVEKLSAAECSCV 98
TGF_beta_Persephin cd19382
transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; ...
 103-197 1.33e-25

transforming growth factor beta (TGF-beta) like domain found in Persephin and similar proteins; Persephin is a member of the glial cell-line-derived neurotrophic factor (GDNF) family with neurotrophic activity on mesencephalic dopaminergic and motor neurons.


Pssm-ID: 381652  Cd Length: 99  Bit Score: 94.84  E-value: 1.33e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758826  103 CGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYDLGLRRLRQ--RRRLRRERVRAQPCCRPTAYEDeVSFLDAH 180
Cdd:cd19382   3 CRLRSLLLRVGDLGLGYDSEETVLFKYCSGGCPRARTNHDLTLSRLLQkgDLPSLGEKIFGGPCCRPTHYED-VAFLDDN 81

                        90
                ....*....|....*..
gi 4758826  181 SRYHTVHELSARECACV 197
Cdd:cd19382  82 HRWHTVEKLSAAACACV 98
TGF_beta_GDNF cd19380
transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived ...
 103-196 9.42e-24

transforming growth factor beta (TGF-beta) like domain found in glial cell line-derived neurotrophic factor (GDNF) and similar proteins; GDNF, also termed astrocyte-derived trophic factor (ATF), is a member of the glial cell-line-derived neurotrophic factor (GDNF) family. It acts as a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.


Pssm-ID: 381650  Cd Length: 96  Bit Score: 89.91  E-value: 9.42e-24
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758826  103 CGLRELEVRVSELGLGYASDETVLFRYCAGACEAAARVYDlGLRRLRQRRRLRRERVRAQPCCRPTAYEDEVSFLDAHSR 182
Cdd:cd19380   4 CVLTEIHLNVTDLGLGYETKEELIFRYCSGSCDAAETTYD-KILKNLTRNKKLVSDKVGQACCRPIAFDDDLSFLDDNLV 82

                        90
                ....*....|....
gi 4758826  183 YHTVHELSARECAC 196
Cdd:cd19380  83 YHTLKKHSAKKCGC 96
TGF_beta pfam00019
Transforming growth factor beta like domain;
103-196 1.80e-10

Transforming growth factor beta like domain;


Pssm-ID: 459632  Cd Length: 102  Bit Score: 55.41  E-value: 1.80e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758826    103 CGLRELEVRVSELGLG--YASDETVLFRYCAGACEAAARVYDLGL--RRLRQRRRLRRERVRAQPCCRPTAYEDeVSFLD 178
Cdd:pfam00019   2 CRRHSLYVDFEDLGWDdwIIAPKGYNAYYCSGSCPSHLNPQLSATnhAILQSLLHSLKPANVPKPCCVPTKLSP-LSVLY 80

                          90       100
                  ....*....|....*....|..
gi 4758826    179 AHS----RYHTVHELSARECAC 196
Cdd:pfam00019  81 YDDegnvVLKTYPDMVVESCGC 102
TGF_beta_SF cd08698
transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta ...
 103-196 7.70e-07

transforming growth factor beta (TGF-beta) like domain found in TGF-beta superfamily; TGF-beta superfamily consists of a large group of cell regulatory proteins, such as TFG-betas, Nodal, Activins/Inhibins, glial cell-line-derived neurotrophic factor (GDNF) family of ligands, bone morphogenetic proteins (BMPs), and growth and differentiation factors (GDFs). They play important roles in developmental and physiological processes in a variety of species, including invertebrates as well as vertebrates, through specific receptor complexes that are composed of type I and type II serine/threonine receptor kinases. The receptor kinases subsequently activate Smad proteins, which then propagate the signals into the nucleus to regulate target gene expression. Proteins from the TGF-beta superfamily are only active as homo- or heterodimer.


Pssm-ID: 381627  Cd Length: 100  Bit Score: 45.55  E-value: 7.70e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758826  103 CGLRELEVRVSELGLGY--ASDETVLFRYCAGACEAAARVYDLGLRRLRQRRRLRRERVRA-QPCCRPTAYEDeVSFL-- 177
Cdd:cd08698   1 CCKQPLYVNFKDLGGLNwiIAPSGFTANYCRGSCNSESSATTNHTKLLQWSRTRRHTPREElKPCCVPTSYEP-LSILyy 79

                        90       100
                ....*....|....*....|.
gi 4758826  178 -DAHSRYHT-VHELSARECAC 196
Cdd:cd08698  80 dNNGTVVETlLPNLIVTECGC 100
TGF_beta_DAF7 cd19378
transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer ...
 103-196 4.35e-03

transforming growth factor beta (TGF-beta) like domain found in Caenorhabditis elegans Dauer larva development regulatory growth factor DAF-7 and similar proteins; DAF-7, also termed abnormal dauer formation protein 7, may act as a negative regulator of dauer larva development by transducing chemosensory information from ASI neurons. It is involved in sensitivity to CO2 levels.


Pssm-ID: 381648  Cd Length: 100  Bit Score: 35.39  E-value: 4.35e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758826  103 CGLRELEVRVSELGLGYasdetVLF------RYCAGACEAAARVYDLGLRRLRQRRRLRRERVRAQPCCRPTAYEDE-VS 175
Cdd:cd19378   3 CCLYDLTIDFEEIGWNF-----IIApkkynaNMCRGDCKSNHHHRPNSASILLNPITRSESKQEHGSCCHPTEYDPItVV 77

                        90       100
                ....*....|....*....|...
gi 4758826  176 FLDAHS--RYHTVHELSARECAC 196
Cdd:cd19378  78 YFNEDGqlKIKTINGMIAKKCSC 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH