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Conserved domains on  [gi|156627581|ref|NP_004614|]
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tetratricopeptide repeat protein 4 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 220-379 3.70e-74

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


:

Pssm-ID: 439174  Cd Length: 153  Bit Score: 227.44  E-value: 3.70e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581 220 EALLQAIKARNIRLSEAACEDEDSASeglgelfLDGLSTENPHGARLSLDGQGRLSWPVLFLYPEYAQSDFISAFHEDSR 299
Cdd:cd21380    1 EKLIKAIKERGIKLEGSKKGESDDLS-------LLEPCHPELSGARVHLDEEGRLVWPVLFLYPEYKQSDFIQAFHEDTT 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581 300 FIDHLMVMFGETPSWDLEQKYCPDNLEVYFEDEDRAELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNFLR 379
Cdd:cd21380   74 FIDHLEVMFEEPPPWDVEKKYTPDNLNVYFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLVKGSEFEKEFLK 153
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-181 1.40e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 63.78  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  64 LQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAA 143
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE---LDPD-LAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 156627581 144 RKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG4785  134 LELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171
 
Name Accession Description Interval E-value
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 220-379 3.70e-74

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439174  Cd Length: 153  Bit Score: 227.44  E-value: 3.70e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581 220 EALLQAIKARNIRLSEAACEDEDSASeglgelfLDGLSTENPHGARLSLDGQGRLSWPVLFLYPEYAQSDFISAFHEDSR 299
Cdd:cd21380    1 EKLIKAIKERGIKLEGSKKGESDDLS-------LLEPCHPELSGARVHLDEEGRLVWPVLFLYPEYKQSDFIQAFHEDTT 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581 300 FIDHLMVMFGETPSWDLEQKYCPDNLEVYFEDEDRAELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNFLR 379
Cdd:cd21380   74 FIDHLEVMFEEPPPWDVEKKYTPDNLNVYFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLVKGSEFEKEFLK 153
Wheel pfam18972
Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human ...
 268-353 5.72e-24

Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.


Pssm-ID: 436877  Cd Length: 114  Bit Score: 95.37  E-value: 5.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  268 LDGQGRLSWPVLFLYPEYAQSDFISAFHEDSRFIDHLMVMFGETPSWDLEQKYCPDNLEVYFEDeDRAELYRVPAKSTLL 347
Cdd:pfam18972   3 DDPESTLIFPVFFLYPLHAQSDFIKAFSETTTPQDHLEYVFPSPPPWDTKKEYTPKNVEVYMET-RTGGLVKVGKKVPLR 81


                  ....*.
gi 156627581  348 QVLQHQ 353
Cdd:pfam18972  82 KVLSSA 87
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-181 1.40e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 63.78  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  64 LQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAA 143
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE---LDPD-LAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 156627581 144 RKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG4785  134 LELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
77-287 5.01e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.25  E-value: 5.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  77 EQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIR 156
Cdd:COG0457   40 DDAEALYNLGLAYLRLGRYEEALADYEQALE---LDPD-DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581 157 GALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKAdkLKRIEQRDVRKANLKEKKERNQNEALLQAIKARNIRLSEA 236
Cdd:COG0457  116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA--LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAA 193

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 156627581 237 ACEDEDSASEGLGELFLDGLSTENPHGARLSLDGQGRLSWPVLFLYPEYAQ 287
Cdd:COG0457  194 EVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYR 244
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 57-171 6.46e-10

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 60.77  E-value: 6.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581   57 ENPDLACLQSIIFDEERSPEEQAKtYKDEGNDYFKEKDYKKAVISYTEGLKKKcADPdlnaVLYTNRAAAQYYLGNFRSA 136
Cdd:TIGR00990 106 ELPEIDESSVANLSEEERKKYAAK-LKEKGNKAYRNKDFNKAIKLYSKAIECK-PDP----VYYSNRAACHNALGDWEKV 179

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 156627581  137 LNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAV 171
Cdd:TIGR00990 180 VEDTTAALELDPDYSKALNRRANAYDGLGKYADAL 214
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 79-160 1.40e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 40.54  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  79 AKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIR-G 157
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAID---LDPN-NAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRkG 77


                 ...
gi 156627581 158 ALC 160
Cdd:PLN03088  78 TAC 80
 
Name Accession Description Interval E-value
CTWD_Cns1 cd21380
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and ...
 220-379 3.70e-74

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1 and similar proteins; Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. The model corresponds to Cns1 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439174  Cd Length: 153  Bit Score: 227.44  E-value: 3.70e-74
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581 220 EALLQAIKARNIRLSEAACEDEDSASeglgelfLDGLSTENPHGARLSLDGQGRLSWPVLFLYPEYAQSDFISAFHEDSR 299
Cdd:cd21380    1 EKLIKAIKERGIKLEGSKKGESDDLS-------LLEPCHPELSGARVHLDEEGRLVWPVLFLYPEYKQSDFIQAFHEDTT 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581 300 FIDHLMVMFGETPSWDLEQKYCPDNLEVYFEDEDRAELYRVPAKSTLLQVLQHQRYFVKALTPAFLVCVGSSPFCKNFLR 379
Cdd:cd21380   74 FIDHLEVMFEEPPPWDVEKKYTPDNLNVYFEDRDKGKLVKVDPKSTLGEVLSHKRYVVKNGTPSFIVLVKGSEFEKEFLK 153
CTWD_Cns1-like cd21377
C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo ...
 220-379 7.62e-45

C-terminal wheel domain found in Saccharomyces cerevisiae Hsp70/Hsp90 co-chaperone Cns1, Homo sapiens tetratricopeptide repeat protein 4 (TTC4), and similar proteins; The family includes Hsp70/Hsp90 co-chaperone Cns1 from Saccharomyces cerevisiae and the human Cns1 homolog tetratricopeptide repeat protein 4 (TTC4), both of which contain a C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. Cns1, also called cyclophilin seven suppressor 1, or STI1 stress-inducible protein homolog, binds to the molecular chaperones Hsp90 (HSC82 and HSP82) and Hsp70 (SSA1). It stimulates SSA1 ATPase activity, but not Hsp90 ATPase activity. It is involved in only a subset of Hsp90 functions. TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses.


Pssm-ID: 439173  Cd Length: 159  Bit Score: 152.11  E-value: 7.62e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581 220 EALLQAIKARNIRLSEAAcededsaseglgelfldgLSTENPHGARLSLDGQGRLSWPVLFLYPEYAQSDFISAFHEDSR 299
Cdd:cd21377    1 KALLSALKSRGIKLGPPL------------------YDEELTGERKPYLDEDGELHWPVLLLYPEVGQSDFIEDFSEDDT 62

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581 300 FIDHLMVMFGET---PSWDLEQKYCPDNLEVYFED--------------EDRAELYRVPAKSTLLQVLQHQRYFVKALTP 362
Cdd:cd21377   63 LGDHLDVMFPEPappLPWDTEGEYTRDNLEVYYETnavkplpsesskagPKEKKWVRVDPDTTLGDVLAHPDYYVIPGIP 142

                        170
                 ....*....|....*..
gi 156627581 363 AFLVCVGSSPFCKNFLR 379
Cdd:cd21377  143 VFYVVPKGSPFEKRFLK 159
Wheel pfam18972
Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human ...
 268-353 5.72e-24

Cns1/TTC4 Wheel domain; The wheel domain is found at the C-terminus of yeast Cns1 and human TTC4 proteins. The structure of the domain shows an overall fold consisting of a twisted five-stranded beta sheet surrounded by several alpha helices. The Hsp90 chaperone machinery in eukaryotes comprises a number of distinct accessory factors. Cns1 is one of the few essential co-chaperones in yeast. Cns1 is important for maintaining translation elongation, specifically chaperoning the elongation factor eEF2. In this context, Cns1 interacts with the novel co-factor Hgh1 and forms a quaternary complex together with eEF2 and Hsp90.


Pssm-ID: 436877  Cd Length: 114  Bit Score: 95.37  E-value: 5.72e-24
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  268 LDGQGRLSWPVLFLYPEYAQSDFISAFHEDSRFIDHLMVMFGETPSWDLEQKYCPDNLEVYFEDeDRAELYRVPAKSTLL 347
Cdd:pfam18972   3 DDPESTLIFPVFFLYPLHAQSDFIKAFSETTTPQDHLEYVFPSPPPWDTKKEYTPKNVEVYMET-RTGGLVKVGKKVPLR 81


                  ....*.
gi 156627581  348 QVLQHQ 353
Cdd:pfam18972  82 KVLSSA 87
CTWD_TTC4 cd21381
C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and ...
 211-353 1.22e-22

C-terminal wheel domain found in Homo sapiens tetratricopeptide repeat protein 4 (TTC4) and similar proteins; TTC4, also called TPR repeat protein 4, is a putative Hsp90 co-chaperone which interacts with CDC6 and shows alterations in transformed cells. It interacts with TBK1 and promotes Sendai virus (SeV)-induced host cell innate immune responses. The model corresponds to TTC4 C-terminal wheel domain consisting of a twisted five-stranded beta sheet surrounded by several alpha helices.


Pssm-ID: 439175  Cd Length: 150  Bit Score: 92.96  E-value: 1.22e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581 211 KEKKERNqneaLLQAIKARNIRL--SEAACEDEDSASEGLgelfldglstENPhgarlsLDGQGRLSWPVLFLYPEYAQS 288
Cdd:cd21381    1 KERKKKT----LKAALKARNITTrtTSQPPELLEDAKILL----------EDP------LDPESQLIFPALLLYPLHLQS 60

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 156627581 289 DFISAFHEDSRFIDHLMVMFGETPSWDLEQKYCPDNLEVYFEDEDrAELYRVPAKSTLLQVLQHQ 353
Cdd:cd21381   61 DFIKAFSELSTPQEHLEYVLPRPWDWDKHEEYTPKNVECYMETES-GGLVKVGKKVPLLKVLSNG 124
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
64-181 1.40e-11

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 63.78  E-value: 1.40e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  64 LQSIIFDEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAA 143
Cdd:COG4785   58 LAAERIDRALALPDLAQLYYERGVAYDSLGDYDLAIADFDQALE---LDPD-LAEAYNNRGLAYLLLGDYDAALEDFDRA 133

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 156627581 144 RKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG4785  134 LELDPDYAYAYLNRGIALYYLGRYELAIADLEKALELD 171
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
77-287 5.01e-10

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 59.25  E-value: 5.01e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  77 EQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIR 156
Cdd:COG0457   40 DDAEALYNLGLAYLRLGRYEEALADYEQALE---LDPD-DAEALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYN 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581 157 GALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKAdkLKRIEQRDVRKANLKEKKERNQNEALLQAIKARNIRLSEA 236
Cdd:COG0457  116 LGLALLELGRYDEAIEAYERALELDPDDADALYNLGIA--LEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAA 193

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|.
gi 156627581 237 ACEDEDSASEGLGELFLDGLSTENPHGARLSLDGQGRLSWPVLFLYPEYAQ 287
Cdd:COG0457  194 EVLLALLLALEQALRKKLAILTLAALAELLLLALALLLALRLAALALYQYR 244
3a0801s09 TIGR00990
mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) ...
 57-171 6.46e-10

mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70); [Transport and binding proteins, Amino acids, peptides and amines]


Pssm-ID: 273380 [Multi-domain]  Cd Length: 615  Bit Score: 60.77  E-value: 6.46e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581   57 ENPDLACLQSIIFDEERSPEEQAKtYKDEGNDYFKEKDYKKAVISYTEGLKKKcADPdlnaVLYTNRAAAQYYLGNFRSA 136
Cdd:TIGR00990 106 ELPEIDESSVANLSEEERKKYAAK-LKEKGNKAYRNKDFNKAIKLYSKAIECK-PDP----VYYSNRAACHNALGDWEKV 179

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 156627581  137 LNDVTAARKLKPCHLKAIIRGALCHLELKHFAEAV 171
Cdd:TIGR00990 180 VEDTTAALELDPDYSKALNRRANAYDGLGKYADAL 214
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
77-202 8.24e-09

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.78  E-value: 8.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  77 EQAKTYKDEGNDYFKEKDYKKAVISYTEGLKKkcaDPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIR 156
Cdd:COG0457    6 DDAEAYNNLGLAYRRLGRYEEAIEDYEKALEL---DPD-DAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNN 81

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 156627581 157 GALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKA-DKLKRIEQ 202
Cdd:COG0457   82 LGLALQALGRYEEALEDYDKALELDPDDAEALYNLGLAlLELGRYDE 128
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
77-165 5.87e-06

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 46.83  E-value: 5.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  77 EQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDLNAVLYtNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIR 156
Cdd:COG4785  105 DLAEAYNNRGLAYLLLGDYDAALEDFDRALE---LDPDYAYAYL-NRGIALYYLGRYELAIADLEKALELDPNDPERALW 180


                 ....*....
gi 156627581 157 GALCHLELK 165
Cdd:COG4785  181 LYLAERKLD 189
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 89-226 9.11e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 46.65  E-value: 9.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  89 YFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELKHFA 168
Cdd:COG2956  120 YEQEGDWEKAIEVLERLLK---LGPE-NAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYE 195

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 156627581 169 EAVNWCDEGLQIDAKEKKLLEMRAKAdkLKRIEQRDVRKANLKEKKERNQNEALLQAI 226
Cdd:COG2956  196 EAIAALERALEQDPDYLPALPRLAEL--YEKLGDPEEALELLRKALELDPSDDLLLAL 251
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 86-192 2.60e-05

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 43.46  E-value: 2.60e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  86 GNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELK 165
Cdd:COG4235   24 GRAYLRLGRYDEALAAYEKALR---LDPD-NADALLDLAEALLAAGDTEEAEELLERALALDPDNPEALYLLGLAAFQQG 99

                         90       100
                 ....*....|....*....|....*..
gi 156627581 166 HFAEAVNWCDEGLQIDAKEKKLLEMRA 192
Cdd:COG4235  100 DYAEAIAAWQKLLALLPADAPARLLEA 126
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
89-183 2.79e-05

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 42.46  E-value: 2.79e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  89 YFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALnDVTAARKLKPCHLKAIIRGALCHLELKHFA 168
Cdd:COG3063    2 YLKLGDLEEAEEYYEKALE---LDPD-NADALNNLGLLLLEQGRYDEAI-ALEKALKLDPNNAEALLNLAELLLELGDYD 76

                         90
                 ....*....|....*
gi 156627581 169 EAVNWCDEGLQIDAK 183
Cdd:COG3063   77 EALAYLERALELDPS 91
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 76-220 3.25e-05

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 43.26  E-value: 3.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  76 EEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAII 155
Cdd:COG4783    1 AACAEALYALAQALLLAGDYDEAEALLEKALE---LDPD-NPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARL 76

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 156627581 156 RGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKAdkLKRIEQRDVRKANLKEKKERNQNE 220
Cdd:COG4783   77 NLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARA--YRALGRPDEAIAALEKALELDPDD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 70-202 3.86e-05

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 45.75  E-value: 3.86e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  70 DEERSPEEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPC 149
Cdd:COG3914   69 AAAAALLLLAALLELAALLLQALGRYEEALALYRRALA---LNPD-NAEALFNLGNLLLALGRLEEALAALRRALALNPD 144

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 156627581 150 HLKAIIRGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKA-DKLKRIEQ 202
Cdd:COG3914  145 FAEAYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNAlQDLGRLEE 198
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 61-181 1.42e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 43.83  E-value: 1.42e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  61 LACLQSIIfdeERSPEEqAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDV 140
Cdd:COG3914   98 LALYRRAL---ALNPDN-AEALFNLGNLLLALGRLEEALAALRRALA---LNPD-FAEAYLNLGEALRRLGRLEEAIAAL 169

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 156627581 141 TAARKLKPCHLKAIIRGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG3914  170 RRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELD 210
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 76-181 2.62e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.10  E-value: 2.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  76 EEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAII 155
Cdd:COG5010   51 AKAFAIESPSDNLYNKLGDFEESLALLEQALQ---LDPN-NPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYS 126

                         90       100
                 ....*....|....*....|....*.
gi 156627581 156 RGALCHLELKHFAEAVNWCDEGLQID 181
Cdd:COG5010  127 NLAALLLSLGQDDEAKAALQRALGTS 152
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 76-202 1.17e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.48  E-value: 1.17e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  76 EEQAKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAII 155
Cdd:COG2956  141 PENAHAYCELAELYLEQGDYDEAIEALEKALK---LDPD-CARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALP 216

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 156627581 156 RGALCHLELKHFAEAVNWCDEGLQIDAKEKKLLEMRAKADKLKRIEQ 202
Cdd:COG2956  217 RLAELYEKLGDPEEALELLRKALELDPSDDLLLALADLLERKEGLEA 263
PLN03088 PLN03088
SGT1, suppressor of G2 allele of SKP1; Provisional
 79-160 1.40e-03

SGT1, suppressor of G2 allele of SKP1; Provisional


Pssm-ID: 215568 [Multi-domain]  Cd Length: 356  Bit Score: 40.54  E-value: 1.40e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  79 AKTYKDEGNDYFKEKDYKKAVISYTEGLKkkcADPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIR-G 157
Cdd:PLN03088   2 AKDLEDKAKEAFVDDDFALAVDLYTQAID---LDPN-NAELYADRAQANIKLGNFTEAVADANKAIELDPSLAKAYLRkG 77


                 ...
gi 156627581 158 ALC 160
Cdd:PLN03088  78 TAC 80
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 86-208 1.42e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.10  E-value: 1.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 156627581  86 GNDYFKEKDYKKAVISYTEGLKKkcaDPDlNAVLYTNRAAAQYYLGNFRSALNDVTAARKLKPCHLKAIIRGALCHLELK 165
Cdd:COG2956   83 AQDYLKAGLLDRAEELLEKLLEL---DPD-DAEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQG 158

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 156627581 166 HFAEAVNWCDEGLQIDAKEKKLLEMRAKAdklkRIEQRDVRKA 208
Cdd:COG2956  159 DYDEAIEALEKALKLDPDCARALLLLAEL----YLEQGDYEEA 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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