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Conserved domains on  [gi|17505191|ref|NP_004616|]
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protein Wnt-7a precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 32-349 0e+00

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


:

Pssm-ID: 381723  Cd Length: 318  Bit Score: 682.93  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  32 LGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAII 111
Cdd:cd19349   1 LGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAII 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 112 AAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKI 191
Cdd:cd19349  81 AAGVAHAITAACTQGNLSDCGCDKEKQGQYNQEEGWKWGGCSADIRYGIGFSKVFVDAREIKQNARTLMNLHNNEAGRKI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 192 LEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYI 271
Cdd:cd19349 161 LEENMKLECKCHGVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYI 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17505191 272 EKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19349 241 EKSPNYCEEDPVTGSVGTQGRMCNKTAQQNNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTCK 318
 
Name Accession Description Interval E-value
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 32-349 0e+00

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 682.93  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  32 LGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAII 111
Cdd:cd19349   1 LGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAII 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 112 AAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKI 191
Cdd:cd19349  81 AAGVAHAITAACTQGNLSDCGCDKEKQGQYNQEEGWKWGGCSADIRYGIGFSKVFVDAREIKQNARTLMNLHNNEAGRKI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 192 LEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYI 271
Cdd:cd19349 161 LEENMKLECKCHGVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYI 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17505191 272 EKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19349 241 EKSPNYCEEDPVTGSVGTQGRMCNKTAQQNNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTCK 318
WNT1 smart00097
found in Wnt-1;
40-349 1.69e-180

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 501.85  E-value: 1.69e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191     40 KIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAI 119
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191    120 TAACTQGNLSDCGCDKEKQGQYhRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLE 199
Cdd:smart00097  81 TRACSEGELDSCGCDYRKRGRA-GGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191    200 CKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFlkikKPLSYRKPMDTDLVYIEKSPNYCE 279
Cdd:smart00097 160 CKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVP----KNSTFKPPTETDLVYLESSPDFCE 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191    280 EDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:smart00097 236 KNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 40-349 1.05e-178

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 497.07  E-value: 1.05e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191    40 KIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGER-TVFGKELKVGSREAAFTYAIIAAGVAHA 118
Cdd:pfam00110   1 KLPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCSTLENKrPVFGKVLKRGTRETAFVYAISSAGVTHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191   119 ITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIK-QNARTLMNLHNNEAGRKILEENMK 197
Cdd:pfam00110  81 VTRACSSGELTSCGCDRKKRGKSSGEGGWEWGGCSDNIDYGYKFSRKFVDAREKKrRDARALMNLHNNEAGRKAVKSNMR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191   198 LECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVepvRASRNKRPTFLKIKKplSYRKPMDTDLVYIEKSPNY 277
Cdd:pfam00110 161 TECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKV---NRRRNKRGRLVPRNS--RFKPPTKNDLVYLEKSPDY 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17505191   278 CEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:pfam00110 236 CERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
 
Name Accession Description Interval E-value
Wnt_Wnt7a cd19349
Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand ...
 32-349 0e+00

Wnt domain found in protein Wnt-7a and similar proteins; Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development and urogenital tract development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381723  Cd Length: 318  Bit Score: 682.93  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  32 LGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAII 111
Cdd:cd19349   1 LGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAII 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 112 AAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKI 191
Cdd:cd19349  81 AAGVAHAITAACTQGNLSDCGCDKEKQGQYNQEEGWKWGGCSADIRYGIGFSKVFVDAREIKQNARTLMNLHNNEAGRKI 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 192 LEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYI 271
Cdd:cd19349 161 LEENMKLECKCHGVSGSCTTKTCWTTLPKFRELGYILKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYI 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17505191 272 EKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19349 241 EKSPNYCEEDPVTGSVGTQGRMCNKTAQQNNGCDLMCCGRGYNTHQYSRVWQCNCKFHWCCYVKCNTCSERTEVYTCK 318
Wnt_Wnt7 cd19339
Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a ...
 37-349 0e+00

Wnt domain found in protein Wnt-7a, Wnt-7b and similar proteins; The family includes Wnt-7a and Wnt-7b. Wnt-7a acts as a canonical Wnt ligand that modulates the synaptic vesicle cycle and synaptic transmission in hippocampal neurons. It also plays an important role in embryonic development, including dorsal versus ventral patterning during limb development, skeleton development, and urogenital tract development. Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381713  Cd Length: 313  Bit Score: 613.53  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  37 ICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVA 116
Cdd:cd19339   1 ICNKIPGLTPRQRAICQSRPDAIVAIGEGAQLGIEECQFQFRNHRWNCTLLGERTVFGQELPVGSREAAFTYAITSAGVA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 117 HAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENM 196
Cdd:cd19339  81 YAITQACSQGNLSDCGCDKSKKGYGKSDEGWKWGGCSADVKYGLRFSRKFVDAREVKRNARSLMNLHNNEAGRKAVEENL 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 197 KLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPN 276
Cdd:cd19339 161 KLECKCHGVSGSCTTKTCWTTLPSFREIGDYLKKKYERARRVEPVRGRRRRRPTFLKLKISRKYKKPRPRDLVYLEKSPN 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17505191 277 YCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19339 241 YCEKDPLTGSLGTVGRRCNRTSTGTDGCDLMCCGRGYNTHQYTKTWQCNCKFHWCCYVKCNTCSERTEEYTCK 313
wnt_Wnt7b cd19350
Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt ...
 32-349 0e+00

Wnt domain found in protein Wnt-7b and similar proteins; Wnt-7b functions in the canonical Wnt/beta-catenin signaling pathway in vascular smooth muscle cells. It is required for normal fusion of the chorion and the allantois during placenta development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381724  Cd Length: 318  Bit Score: 566.56  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  32 LGASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAII 111
Cdd:cd19350   1 LGANIICNKIPGLAPRQRAICQSRPDAIIVIGEGAQMGINECQYQFRYGRWNCSALGERTVFGQELRVGSREAAFTYAIT 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 112 AAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKI 191
Cdd:cd19350  81 AAGVAHAVTAACSQGNLSNCGCDREKQGYYNQEEGWKWGGCSADIKYGIDFSRKFVDAREIKKNARRLMNLHNNEAGRKV 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 192 LEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKPMDTDLVYI 271
Cdd:cd19350 161 LEERMKLECKCHGVSGSCTTKTCWTTLPKFREIGYVLKEKYNAAVQVEVVRASRLRQPTFLKIKKRRSYQKPMETDLVYI 240

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17505191 272 EKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19350 241 ERSPNYCEEDAATGSVGTQGRLCNRTSPHTDGCDLMCCGRGYNTHQYTKVWQCNCKFHWCCFVKCNTCSERTEVFTCK 318
WNT1 smart00097
found in Wnt-1;
40-349 1.69e-180

found in Wnt-1;


Pssm-ID: 128408  Cd Length: 305  Bit Score: 501.85  E-value: 1.69e-180
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191     40 KIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAI 119
Cdd:smart00097   1 SLPGLSRRQRRLCRANPDVMISVAEGAQEGIEECQHQFRFRRWNCSTLDNASVFGKVLRQGTRETAFVYAISSAGVAHAV 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191    120 TAACTQGNLSDCGCDKEKQGQYhRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLE 199
Cdd:smart00097  81 TRACSEGELDSCGCDYRKRGRA-GGRGWKWGGCSDNIDFGIRFSREFVDARERGKDARALMNLHNNEAGRLAVKKTMKRE 159

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191    200 CKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFlkikKPLSYRKPMDTDLVYIEKSPNYCE 279
Cdd:smart00097 160 CKCHGVSGSCTVKTCWLQLPDFRKVGDYLKEKYDGASEVEVDKRGTNKAPVP----KNSTFKPPTETDLVYLESSPDFCE 235

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191    280 EDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:smart00097 236 KNPKTGSLGTQGRQCNKTSKGLDGCDLLCCGRGYNTRTVEVVERCNCKFHWCCYVKCKQCRETVEKHTCK 305
wnt pfam00110
wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, ...
 40-349 1.05e-178

wnt family; Wnt genes have been identified in vertebrates and invertebrates but not in plants, unicellular eukaryotes or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families.


Pssm-ID: 459677  Cd Length: 307  Bit Score: 497.07  E-value: 1.05e-178
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191    40 KIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGER-TVFGKELKVGSREAAFTYAIIAAGVAHA 118
Cdd:pfam00110   1 KLPGLSPRQRRLCRRNPDVMASVAEGAQLAIEECQHQFRNRRWNCSTLENKrPVFGKVLKRGTRETAFVYAISSAGVTHA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191   119 ITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIK-QNARTLMNLHNNEAGRKILEENMK 197
Cdd:pfam00110  81 VTRACSSGELTSCGCDRKKRGKSSGEGGWEWGGCSDNIDYGYKFSRKFVDAREKKrRDARALMNLHNNEAGRKAVKSNMR 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191   198 LECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVepvRASRNKRPTFLKIKKplSYRKPMDTDLVYIEKSPNY 277
Cdd:pfam00110 161 TECKCHGVSGSCSVKTCWKALPPFREVGDRLKEKYDGAVKV---NRRRNKRGRLVPRNS--RFKPPTKNDLVYLEKSPDY 235

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17505191   278 CEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:pfam00110 236 CERNPKTGSLGTRGRECNKTSSGPDGCDLLCCGRGYNTRTVTVTERCNCKFHWCCYVKCKTCTETVEVYTCK 307
Wnt_Wnt2_like cd19334
Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and ...
 33-349 2.47e-148

Wnt domain found in protein Wnt-2, Wnt-2b and similar proteins; The family includes Wnt-2 and Wnt-2b. Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381708  Cd Length: 314  Bit Score: 420.59  E-value: 2.47e-148
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  33 GASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALG-ERTVFGKELKVGSREAAFTYAII 111
Cdd:cd19334   1 GARVICDNIPGLVSKQRQLCRKHPDVMVSIGEGAKLGVKECQYQFRNQRWNCSTVDrDATVFGKVLLKGSREAAFVYAIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 112 AAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEG-WKWGGCSADIRYGIGFAKVFVDAREIKQN-ARTLMNLHNNEAGR 189
Cdd:cd19334  81 SAGVVHAITRACSKGELLNCACDPTKRGKGRDSKGeFDWGGCSDNVKYGINFARKFVDARERRVRdARALMNLHNNRAGR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 190 KILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVepvraSRNKRPTFLKIKKpLSYRKPMDTDLV 269
Cdd:cd19334 161 KAVKKNLKLQCKCHGVSGSCTIRTCWRALAEFREVGDYLREKYDGAVQV-----TMNQSGTNLLAAN-KGHKKPTRSDLV 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 270 YIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19334 235 YFESSPDYCVPNPETGSLGTAGRVCNKTSTGTDGCDIMCCGRGYDTTRVRRTTKCNCKFHWCCQVKCKTCTETVDVHTCK 314
Wnt cd13113
Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary ...
 59-348 6.19e-147

Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family; Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about the structure of Wnt proteins, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. Wnt signaling mediated by Wnt proteins orchestrates and influences a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381706  Cd Length: 288  Bit Score: 415.92  E-value: 6.19e-147
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  59 IIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQ 138
Cdd:cd13113   2 MESIAEGAQLALKECQRQFANRRWNCSTFNEPLLFGKILKRGTRETAFVHAITSAGVTHAITRACSRGKLKNCGCDRTRQ 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 139 GqYHRDEGWKWGGCSADIRYGIGFAKVFVDARE--IKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWT 216
Cdd:cd13113  82 G-PEGQGDWTWGGCSDNIKFGIKFSRKFLDAREkkKGSDARSLMNLHNNEAGRKAVKKTMKKKCKCHGVSGSCTTKTCWR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 217 TLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPtflkIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNK 296
Cdd:cd13113 161 QLPSFREIGDYLKEKYDNAVKVKLNNNGSGLRL----VPKRSRFRSPTETDLVYLEESPDYCEPNPTLGSLGTAGRECNP 236

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 17505191 297 TAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTC 348
Cdd:cd13113 237 TSPGPDSCELLCCGRGYRTETEIVTEKCNCKFVWCCEVKCETCRRTVERYTC 288
Wnt_Wnt4 cd19336
Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling ...
 38-349 1.02e-146

Wnt domain found in protein Wnt-4 and similar proteins; Wnt-4 may function as a signaling molecule which affects the development of discrete regions of tissues. Its overexpression may be associated with abnormal proliferation in human breast tissue. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381710  Cd Length: 310  Bit Score: 416.33  E-value: 1.02e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  38 CNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAH 117
Cdd:cd19336   1 CESLKGLTKRQVQFCKRNLEVMDSVRRGAQLAIEECQFQFRNRRWNCSTLDKEPVFGKVLNQGTREAAFVHAISSAGVAH 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 118 AITAACTQGNLSDCGCDKEKQGqyHRDEGWKWGGCSADIRYGIGFAKVFVDARE----IKQNARTLMNLHNNEAGRKILE 193
Cdd:cd19336  81 AVTRACSSGELEKCGCDRSVRG--RSPEGFQWSGCSDNVAYGVAFSKSFVDARErrkgRASSSRALMNLHNNEAGRKAIE 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 194 ENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRptfLKIKKPLsYRKPMDTDLVYIEK 273
Cdd:cd19336 159 KNMRVECKCHGVSGSCELKTCWRAMPTFREVGNILKEKFDGATEVQQKRIGSRPV---LVPKNPQ-FKPHTDADLVYLDS 234

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17505191 274 SPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19336 235 SPDFCEPDPKTGSLGTHGRVCNKTSKAIDGCDLLCCGRGYVTRTEEVVERCSCKFHWCCYVKCKTCRREVEVHTCR 310
Wnt_Wnt6 cd19338
Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling ...
 37-349 1.26e-146

Wnt domain found in protein Wnt-6 and similar proteins; Wnt-6 may function as a signaling molecule which affects the development of discrete regions of tissues. It may promote tumorigenesis in gastrointestinal cancer and cervical cancer. It can compensate for the absence of ectoderm and can induce the formation of muscle cells in the limb. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381712  Cd Length: 310  Bit Score: 416.24  E-value: 1.26e-146
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  37 ICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSalGERTVFGKELKVGSREAAFTYAIIAAGVA 116
Cdd:cd19338   6 ICRKTRRLKGKQREICRKEPEILEEVAKGAKLGIRECQYQFRNRRWNCS--TSRKSFGKILKRDTRETAFVYAITSAGVT 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 117 HAITAACTQGNLSDCGCDKEKQGQyHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQN-ARTLMNLHNNEAGRKILEEN 195
Cdd:cd19338  84 YSVTRACSMGELLQCGCDKSKRGK-STEGEWEWGGCSDNVRYGYRKSREFMDAKEKNRSdIRTLMNLHNNEAGRLAVKNN 162

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 196 MKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPvrasRNKRPTFLKIKKPLsyRKPMDTDLVYIEKSP 275
Cdd:cd19338 163 MRKECKCHGLSGSCTLKTCWRKMPPFREVGDRLKERFDGAIKVKG----SNDGKSLIPEGKTI--KPPTKEDLVYLEESP 236

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17505191 276 NYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19338 237 DFCEPNKKTGSLGTRGRECNRTSMGVDGCDLLCCGRGYQTEVRVVEENCNCRFHWCCEVKCETCKVRKEIHTCN 310
Wnt_Wnt16 cd19344
Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and ...
 44-349 7.02e-144

Wnt domain found in protein Wnt-16 and similar proteins; Wnt-16 is a mixed canonical and noncanonical Wnt ligand involved in the regulation of postnatal bone homeostasis. It promotes bone formation and inhibits bone resorption. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381718  Cd Length: 306  Bit Score: 408.93  E-value: 7.02e-144
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  44 LAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAAC 123
Cdd:cd19344   1 LVSQQRRLCKKKPEAIPSVSEGARLGIYECQHQFRHERWNCSTTNDQNVFGKTLSRGTKETAFIYAITSAGVVHAVTRAC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 124 TQGNLSDCGCDKEKQGQYHrDEGWKWGGCSADIRYGIGFAKVFVDA-----REIKQNARTLMNLHNNEAGRKILEENMKL 198
Cdd:cd19344  81 SAGNLTDCSCDSRRQGQSA-SEGWKWGGCSDNVDYGIWFARKFVDApekseRKRSRDVRSLMNLHNNEVGRQAIARLMKV 159

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 199 ECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKK-PLSYrkpmdTDLVYIEKSPNY 277
Cdd:cd19344 160 KCRCHGVSGSCEVKTCWKTMPSFEEVGDFLKQKYENSIQIATKKSKRRLRRRERRKRKvPISK-----DELVYIHKSPNY 234

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 17505191 278 CEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19344 235 CVRDPKKGILGTSGRECNRTSTGPDSCDLLCCGRGYNTQVVRHVERCNCKFVWCCYVKCKTCETMTDVHTCK 306
Wnt_Wnt5 cd19337
Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a ...
 38-349 3.26e-139

Wnt domain found in protein Wnt-5a, Wnt-5b and similar proteins; The family includes Wnt-5a and Wnt-5b, both of which are secreted growth factors that belong to the noncanonical members of the Wingless-related MMTV-integration family. Wnt-5a can activate or inhibit canonical Wnt signaling, depending on receptor context. It specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). The overexpression of Wnt-5b is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381711  Cd Length: 313  Bit Score: 397.38  E-value: 3.26e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  38 CNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAH 117
Cdd:cd19337   1 CDQLRGLSPGQRKLCQLYQDHMPSVGRGAKLAIEECQYQFRYRRWNCSTPDSSSVFGPVTNIGTREAAFTYAISAAGVVH 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 118 AITAACTQGNLSDCGCDKEKQ-GQYHRDegWKWGGCSADIRYGIGFAKVFVDARE--------IKQNARTLMNLHNNEAG 188
Cdd:cd19337  81 AIARACREGNLSTCGCSRERRpKDLPRD--WLWGGCGDNIEYGYKFAKEFIDAREretnyprhSRELARVLMNLHNNEAG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 189 RKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPvrasrNKRPTFLKIKKPlSYRKPMDTDL 268
Cdd:cd19337 159 RRAVYEKARVACKCHGVSGSCSLKTCWRQLAPFREVGDRLKDKYDGAVKVKL-----NRRGTLLRRRNS-RFNKPTKDDL 232

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 269 VYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTC 348
Cdd:cd19337 233 VYLDDSPDYCERNPKTGSLGTKGRECNKTSSGTDGCELLCCGRGYNTKKVEVVERCHCKFHWCCEVKCKTCEKIVDVHIC 312


                .
gi 17505191 349 K 349
Cdd:cd19337 313 K 313
Wnt_Wnt3_Wnt3a cd19335
Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called ...
 35-349 5.56e-139

Wnt domain found in proto-oncogene Wnt-3 and similar proteins; Wnt-3, also called proto-oncogene Int-4, functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It is required for normal embryonic development, and especially for limb development. Wnt-3a functions in the canonical Wnt signaling pathway and plays crucial roles in both proliferation and differentiation processes in several types of stem cells. Wnt3a stimulates the migration and invasion of trophoblasts and induce the survival, proliferation, and migration of human embryonic kidney (HEK) 293 cells. It also up-regulates genes implicated in melanocyte differentiation and increases the expression and nuclear localization of the transcriptional co-activator with PDZ-binding motif (TAZ), a transcriptional modulator involved in activating osteoblastic differentiation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381709  Cd Length: 314  Bit Score: 396.76  E-value: 5.56e-139
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  35 SIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERT-VFGKELKVGSREAAFTYAIIAA 113
Cdd:cd19335   1 PILCGSIPGLVPKQLRFCRNYTELMPSVAEGAKLGIQECQHQFRGRRWNCTTIEGDLsVFGPVLDKASRESAFVHAIASA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 114 GVAHAITAACTQGNLSDCGCDKEKQGQyhRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILE 193
Cdd:cd19335  81 GVAHAVTRACAEGDSTSCGCDSRHKGP--PGEGWRWGGCSEDVEFGVRFSREFADARENRPDARSAMNRHNNEAGRQAIL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 194 ENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEA--VHVEPVRASRNKRPTFlkIKKPLSYRKPMDTDLVYI 271
Cdd:cd19335 159 DNMELKCKCHGLSGSCELKTCWWAQPDFRKIGDYLKDKYDSAseMVVERHRESRGWVETL--RPKYKLFKPPTERDLIYY 236

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 17505191 272 EKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19335 237 EESPNFCEPNPETGSFGTRGRECNVTSHGIDGCDLLCCGRGYNTRTEKRTEKCHCIFVWCCYVSCQECIRVYDVHTCK 314
Wnt_Wnt10 cd19342
Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein ...
 35-349 6.33e-133

Wnt domain found in protein Wnt-10a, Wnt-10b and similar proteins; The family includes protein Wnt-10a and Wnt-10b. Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency, and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381716  Cd Length: 316  Bit Score: 381.61  E-value: 6.33e-133
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  35 SIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERT------VFgkeLKVGSREAAFTY 108
Cdd:cd19342   1 NTVCRTFPGLTREQLELCRRYPDVTASAIQGIQLAVHECQRQFRDHRWNCSSLETKNknphtsPI---LSRGYRETAFAY 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 109 AIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAG 188
Cdd:cd19342  78 AISAAGVAHQVARACSLGKLLSCGCDRSRRGKRSSGNDWKWGGCSHNLDFGEKFSRKFLDSREKARDIHSRMNLHNNRAG 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 189 RKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPvrASRNKRPTFLKIKKPLSYRKPMDTDL 268
Cdd:cd19342 158 RLAVSENMERKCKCHGMSGSCELKTCWKAAPDFREVGDILKEKYDHATLVDQ--SNLNNGARRRRLTRRKRRRRPPKTDL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 269 VYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTC 348
Cdd:cd19342 236 VYYERSPNFCEADPSLDSPGTRGRVCNKTSTGPDSCDSLCCGRGYNTVRQTRTERCNCRFHWCCYVVCEKCTETEWVTVC 315


                .
gi 17505191 349 K 349
Cdd:cd19342 316 K 316
Wnt_Wnt11 cd19343
Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule ...
 44-349 1.55e-123

Wnt domain found in protein Wnt-11 and similar proteins; Wnt-11 may be a signaling molecule which has possible roles in the development of skeleton, kidney and lung. It is a positive regulator of the Wnt signaling pathway, which plays a crucial role in carcinogenesis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381717  Cd Length: 305  Bit Score: 357.34  E-value: 1.55e-123
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  44 LAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAAC 123
Cdd:cd19343   1 LVGDQVKLCRRNLELMPSVVEAARLTVDTCQEQFADRRWNCSSIELAPNFTPDLTRGTREQAFVYALSSAALTHTIARAC 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 124 TQGNLSDCGCD---KEKQgqyhrDEGWKWGGCSADIRYGIGFAKVFVDA-----REIKQNARTLMNLHNNEAGRKILEEN 195
Cdd:cd19343  81 ASGALPGCGCGrlpREPP-----DGDFKWGGCGDNVRYGLRFAKRFTDApekkkKKKKRQARALMNLHNNRVGRKAVRDS 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 196 MKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPlSYRKpmdTDLVYIEKSP 275
Cdd:cd19343 156 LETQCKCHGVSGSCSVKTCWKALPDLSEVASRLKRKYARAVEVVSRKVGSRRKLVPKSLKVR-PYTK---DDLIYLTKSP 231

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 17505191 276 NYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19343 232 DYCLPDEKLGSLGTRGRECNKTSVGSDSCDSMCCGRGYRTYTVEVVERCHCKYHWCCYVKCKTCRRTVEVHVCK 305
Wnt_Wnt2b cd19346
Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, ...
 33-349 3.07e-120

Wnt domain found in protein Wnt-2b and similar proteins; Wnt-2b, also called protein Wnt-13, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a redundant role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381720  Cd Length: 314  Bit Score: 349.22  E-value: 3.07e-120
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  33 GASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALG-ERTVFGKELKVGSREAAFTYAII 111
Cdd:cd19346   1 GARVICDNIPGLVNKQRQLCQRHPDIMQSIGEGAKEWIRECQHQFRHHRWNCSTLDrDHTVFGRVMLRSSREAAFVYAIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 112 AAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEG-WKWGGCSADIRYGIGFAKVFVDAREIK-QNARTLMNLHNNEAGR 189
Cdd:cd19346  81 SAGVVYAITRACSQGELKSCSCDPHKRGRSHDERGeFDWGGCSDNINYGIKFAKAFVDAKEKKeKDARALMNLHNNRCGR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 190 KILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVepvraSRNKRPTFLKIKKPlSYRKPMDTDLV 269
Cdd:cd19346 161 MAVKRFMKLECKCHGVSGSCTLRTCWLAMSDFRKTGDYLRKRYNGAVQV-----TMNQDGTGFTVANK-NFRKATKTDLV 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 270 YIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19346 235 YFENSPDYCVMDKSAGSLGTAGRVCNKSSRGTDGCEVMCCGRGYDTTRVTRVTKCECKFHWCCAVRCKECEETVDVHTCK 314
Wnt_Wnt1 cd19333
Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called ...
 44-348 7.86e-119

Wnt domain found in proto-oncogene Wnt-1 and similar proteins; Wnt-1, also called proto-oncogene Int-1, acts in the canonical Wnt signaling pathway by promoting beta-catenin-dependent transcriptional activation. It plays a role in osteoblast function, bone development and bone homeostasis. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381707  Cd Length: 311  Bit Score: 345.49  E-value: 7.86e-119
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  44 LAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGER---TVFGKELKVGSREAAFTYAIIAAGVAHAIT 120
Cdd:cd19333   1 LTKKQRRLVRQNPGTLHAIARGARMAIKECKWQFRNRRWNCPTTDSRggpNVFGKILNRGCRETAFIYAITSAAVTHSVA 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 121 AACTQGNLSDCGCDKEKQGQYHRDegWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLEC 200
Cdd:cd19333  81 RACSEGSIESCSCDYRRRGPGGPD--WEWGGCSDNIDFGRKFSREFVDAGEKGRDLRYLMNLHNNEAGRVHVSSEMRQEC 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 201 KCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVE-----PVRASRNKRPTFLKIKKPlSYRKPMDTDLVYIEKSP 275
Cdd:cd19333 159 KCHGMSGSCTVKTCWMRLPTFRTVGDRLKDRFDGASRVAygnngNNRGSRRAKKFLLEPENP-NHKPPTSKDLVYFEESP 237

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 17505191 276 NYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTC 348
Cdd:cd19333 238 NFCEKNPKLGTLGTRGRECNATSIGLDGCDLMCCGRGYRTETEEVKERCNCTFHWCCEVKCENCTRTRTVHTC 310
Wnt_Wnt5a cd19347
Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor ...
 38-349 9.66e-114

Wnt domain found in protein Wnt-5a and similar proteins; Wnt-5a is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. It can activate or inhibit canonical Wnt signaling, depending on receptor context. Wnt-5a specifically regulates dendritic spine formation in rodent hippocampal neurons, resulting in postsynaptic development that promotes the clustering of the postsynaptic density protein 95 (PSD-95). Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381721  Cd Length: 312  Bit Score: 332.80  E-value: 9.66e-114
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  38 CNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAH 117
Cdd:cd19347   1 CSQLAGLSQGQKKLCQLYQDHMQYIGEGAKTGIKECQYQFRHRRWNCSTVDNTSVFGRVMQIGSRETAFTYAISAAGVVN 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 118 AITAACTQGNLSDCGCDKEKQGQ-YHRDegWKWGGCSADIRYGIGFAKVFVDAREIK--------QNARTLMNLHNNEAG 188
Cdd:cd19347  81 AVSRACREGELSTCGCSRAARPKdLPRD--WLWGGCGDNLEYGYRFAKEFVDAREREkiyqkgsyESARTLMNLHNNEAG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 189 RKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEpvrasRNKRPTFLKIKKplSYRKPMDTDL 268
Cdd:cd19347 159 RRTVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDALKEKYDSAAAMK-----LNSRGKLVQVNS--RFNPPTTLDL 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 269 VYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTC 348
Cdd:cd19347 232 VYIDPSPDYCVRNESTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQTERCHCKFHWCCYVKCKKCTEIVDQFVC 311


                .
gi 17505191 349 K 349
Cdd:cd19347 312 K 312
Wnt_Wnt2 cd19345
Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein ...
 33-349 1.71e-113

Wnt domain found in protein Wnt-2 and similar proteins; Wnt-2, also called Int-1-like protein 1 (INT1L1), or Int-1-related protein (IRP), functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family. It plays an important role in embryonic lung development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381719  Cd Length: 314  Bit Score: 332.28  E-value: 1.71e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  33 GASIICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALG-ERTVFGKELKVGSREAAFTYAII 111
Cdd:cd19345   1 GSRVMCDNIPGLVSRQRQLCHRHPEVMQAIGSGVKEWIAECQHQFRNHRWNCNTLDrDHSLFGRLLLRSSRESAFVYAIS 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 112 AAGVAHAITAACTQGNLSDCGCDKEKQGQYHRDEG-WKWGGCSADIRYGIGFAKVFVDAREIK-QNARTLMNLHNNEAGR 189
Cdd:cd19345  81 SAGVVFAITRACSQGELKSCSCDPKKKGSSKDSKGsFDWGGCSDNIDYGIRFARAFVDAKERKgKDARALMNLHNNRAGR 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 190 KILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVepvraSRNKRPTFLKIKKPlSYRKPMDTDLV 269
Cdd:cd19345 161 KAVKRFMTLECKCHGVSGSCTVRTCWLAMADFRKTGDYLRKKYNGAIQV-----VMNQDGTGFTVANK-HFKKPTKNDLV 234

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 270 YIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19345 235 YFENSPDYCVRDRDAGSLGTAGRVCNRTSRGMDGCEVMCCGRGYDTSRVGRMTKCECKFHWCCAVRCKDCHQQVDVHTCK 314
Wnt_Wnt5b cd19348
Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor ...
 38-349 3.28e-113

Wnt domain found in protein Wnt-5b and similar proteins; Wnt-5b is a secreted growth factor that belongs to the noncanonical members of the Wingless-related MMTV-integration family. Its overexpression is associated with cancer aggressiveness. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381722  Cd Length: 312  Bit Score: 331.56  E-value: 3.28e-113
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  38 CNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAH 117
Cdd:cd19348   1 CSQLTGLSPGQRKLCQLYQDHMVYIGEGAKTGIKECQYQFRQRRWNCSTVDNTSVFGRVMQIGSRETAFTYAVSAAGVVN 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 118 AITAACTQGNLSDCGCDKEKQGQ-YHRDegWKWGGCSADIRYGIGFAKVFVDAREIKQN--------ARTLMNLHNNEAG 188
Cdd:cd19348  81 AISRACREGELSTCGCSRAARPKdLPRD--WLWGGCGDNVEYGYRFAKEFVDAREREKNypkgseehARTLMNLQNNEAG 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 189 RKILEENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVhvepvrASRNKRPTFLKIKKPlSYRKPMDTDL 268
Cdd:cd19348 159 RRAVYNLADVACKCHGVSGSCSLKTCWLQLADFRKVGDLLKEKYDSAA------AMRINRKGKLELVNS-RFNPPTAEDL 231

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 269 VYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTC 348
Cdd:cd19348 232 VYIDPSPDYCLRNETTGSLGTQGRLCNKTSEGMDGCELMCCGRGYDQFKTVQVERCHCKFHWCCYVKCKKCTEIVDQFVC 311


                .
gi 17505191 349 K 349
Cdd:cd19348 312 K 312
Wnt_Wnt10a cd19355
Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ...
 37-349 1.72e-100

Wnt domain found in protein Wnt-10a and similar proteins; Wnt-10a plays a role in normal ectoderm development. It is required for normal postnatal development and maintenance of tongue papillae and sweat ducts, as well as normal hair follicle function. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381729  Cd Length: 302  Bit Score: 298.82  E-value: 1.72e-100
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  37 ICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKV---GSREAAFTYAIIAA 113
Cdd:cd19355   3 VCLTLPGLTRRQLEVCMRHPDVTASAIQGIQIAIHECQHQFRDHRWNCSSLETRNKIPYESVVfsrGFRESAFAYAIAAA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 114 GVAHAITAACTQGNLSDCGCDkekqgqyhrdegWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILE 193
Cdd:cd19355  83 GVVHAVSNACAMGKLKACGCD------------WEWGGCSPDVEYGERFSKDFLDSRETYRDIHARMRLHNNRVGRQVVM 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 194 ENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPvrasRNKRPTFLKIKKPLSYRKPMDTDLVYIEK 273
Cdd:cd19355 151 DNMRRKCKCHGTSGSCQLKTCWQVTPEFRTVGSLLKDRFYVATLIKP----HNRNTGQLEPGHAPHRRRASINDLVYFEK 226

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17505191 274 SPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19355 227 SPDFCEREPRLDSAGTQGRICNKTSPGMDNCESLCCGRGHNILRQTRSERCNCKFHWCCYVVCEECRITEWVSVCK 302
Wnt_Wnt8 cd19340
Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a ...
 62-348 1.03e-99

Wnt domain found in protein Wnt-8a, Wnt-8b and similar proteins; The family includes Wnt-8a and Wnt-8b. Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381714  Cd Length: 301  Bit Score: 296.51  E-value: 1.03e-99
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  62 IGEGSQMGLDECQFQFRNGRWNCSAlgERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQY 141
Cdd:cd19340  13 VAAGAQLAMEECQYQFKWDRWNCPE--SAFFSQKNNPSATRETAFVHAISSAGVMYTLTRNCSLGHFEGCGCDDSKKGSK 90

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 142 HrDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQF 221
Cdd:cd19340  91 G-GEGWTWGGCSDNVKFGERVSKKFLDSLETGQDAQALMNLHNNRAGRKAVRKTMKKTCKCHGVSGSCSTQTCWMQLAPF 169

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 222 RELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPLSYRKpmdtDLVYIEKSPNYCEEDPVTGSVGTQGRAC------N 295
Cdd:cd19340 170 REIGTDLKRKYDRAVRVDYENGGLRETNGSRAIKLLNIKKN----DLVYLEKSPNYCRANVTLGWPGTLGRQCsrdkkeS 245

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*
gi 17505191 296 KTAPQASGCDLMCCGRGYN-THQYARV-WQCNCKFHWCCYVKCNTCSERTEMYTC 348
Cdd:cd19340 246 VSRWERKSCRRLCRACGLKvRKKVVEVtSSCNCKFHWCCEVKCETCVELVIEYTC 300
Wnt_Wnt10b cd19356
Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, ...
 37-349 6.61e-94

Wnt domain found in protein Wnt-10b and similar proteins; Wnt-10b, also called protein Wnt-12, specifically activates canonical Wnt/beta-catenin signaling and thus triggers beta-catenin/LEF/TCF-mediated transcriptional programs. It is involved in signaling networks controlling stemness, pluripotency and cell fate decisions. Wnt-10b is unique and plays an important role in differentiation of epithelial cells in the hair follicle. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381730  Cd Length: 299  Bit Score: 281.78  E-value: 6.61e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  37 ICNKIPGLAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSAL---GERTVFGKELKVGSREAAFTYAIIAA 113
Cdd:cd19356   3 VCLTLPGLSKRQMGLCVRSPDVTASALQGIQIAIHECQHQLRDQRWNCSSLeggGKLPHDSAILKRGFRESAFSFSLLAA 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 114 GVAHAITAACTQGNLSDCGCdkekqgqyhrdeGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILE 193
Cdd:cd19356  83 GVMHSVATACSLGKLRGCGC------------EWEWGGCSHDIEFGEKFSRDFLDSRESPRDIQARMRIHNNRVGRQVVT 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 194 ENMKLECKCHGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEpvraSRNKRPTflkIKKPLSYRKPMDTDLVYIEK 273
Cdd:cd19356 151 ENMKRKCKCHGTSGSCQFKTCWHVTPEFRLVGALLREKFQRAIFIN----SHNKNSG---VFLPRLRPRRLARELVYFEK 223

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 17505191 274 SPNYCEEDPVTGSVGTQGRACNKTAPQASGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19356 224 SPDFCERDPAVDSPGTQGRICNKTSPGMDGCGSLCCGRGHNILKQTRSERCHCRFHWCCYVLCEECRVTEWVNVCK 299
Wnt_Wnt9 cd19341
Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a ...
 44-349 6.80e-94

Wnt domain found in protein Wnt-9a, Wnt-9b and similar proteins; The family includes Wnt-9a and Wnt-9b, both of which function in the canonical Wnt/beta-catenin signaling pathway. Wnt-9a, also called protein Wnt-14, is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt-9b, also called protein Wnt-14b, or protein Wnt-15, plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381715  Cd Length: 299  Bit Score: 281.87  E-value: 6.80e-94
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  44 LAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTVFgkeLKVGSREAAFTYAIIAAGVAHAITAAC 123
Cdd:cd19341   1 LSRRQRRMCRRDPGLAETLLEAIRLSVLECQEQFRYERWNCSLGKYRINL---LKKGYKETAFLYAISSAGLTHSVARAC 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 124 TQGNLSDCGCDKEKQGQYHRdEGWKWGGCSADIRYGIGFAKVFVDAREI-KQNARTLMNLHNNEAGRKILEENMKLECKC 202
Cdd:cd19341  78 SSGRLDRCTCDESFSLEENR-QTWLWGGCGDNIKYGKKFTRRFLQLKKKsGKDLRAEIDRHNSEVGIRVVREGVKKTCKC 156

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 203 HGVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEpVRASRNKRPTFLKIKKPLSYRK---PMDTDLVYIEKSPNYCE 279
Cdd:cd19341 157 HGVSGSCTVKTCWKQLAPFNEIGKILKRKYEKAVKVV-SENNAATGGSQLRKGKSGSVKKksrPRRKDLVYLEKSPSFCR 235

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 280 EDPVtgSVGTQGRACNKTApqasGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19341 236 STRY--SPGTKGRRCLKGD----NCDTLCCGRGYNTQSEVVVKPCKCRVVWCCQVECKTCTEREEIYTCK 299
Wnt_Wnt9b cd19354
Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b ...
 44-349 2.61e-86

Wnt domain found in protein Wnt-9b and similar proteins; Wnt-9b, also called protein Wnt-14b or Wnt-15, functions in the canonical Wnt/beta-catenin signaling pathway. It plays a central role in the regulation of mesenchymal to epithelial transitions underlying organogenesis of the mammalian urogenital system. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381728  Cd Length: 297  Bit Score: 262.53  E-value: 2.61e-86
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  44 LAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGErtvfGKELKVGSREAAFTYAIIAAGVAHAITAAC 123
Cdd:cd19354   1 LSRRQKRLCRREPGLAETLRDAVRLGLLECQFQFRSERWNCSLEGR----GSLLKRGFKETAFLYAVSSAALTHSLAKAC 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 124 TQGNLSDCGCDkEKQGQYHRdEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCH 203
Cdd:cd19354  77 SSGRMERCTCD-DSPGLENR-EAWQWGVCGDNLKYSTKFLKNFLGQKKGSKDLRARVDAHNTNVGIKAVKSGLKTTCKCH 154

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 204 GVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKK---PLSYRKPMDTDLVYIEKSPNYCEe 280
Cdd:cd19354 155 GVSGSCAVRTCWKQLSPFHETGRLLKLKYENAVKVHSVTNDATGETELWSPERhghTLKGHSPRSTDLVYLEDSPSFCR- 233

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17505191 281 dPVTGSVGTQGRACNKTApqasGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19354 234 -PSKYSPGTAGRTCSRET----NCDSLCCGRGYNTQSRLVTFSCHCQVQWCCYVECQQCVQEEEVYTCK 297
Wnt_Wnt8b cd19352
Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in ...
 62-348 2.36e-79

Wnt domain found in protein Wnt-8b and similar proteins; Wnt-8b may play an important role in the development and differentiation of certain forebrain structures, notably the hippocampus. It acts as a suppressor of early eye and retinal progenitor formation. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381726  Cd Length: 305  Bit Score: 244.93  E-value: 2.36e-79
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  62 IGEGSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQY 141
Cdd:cd19352  14 VAAGAQSGIEECKYQFAWDRWNCPERALQLSSHSGLRSANRETAFVHAISSAGVMYTLTRNCSLGDFDNCGCDDSRNGQL 93

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 142 HrDEGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQF 221
Cdd:cd19352  94 G-GQGWLWGGCSDNVGFGEAISKQFVDALETGQDARAAMNLHNNEAGRKAVKGTMKRTCKCHGVSGSCTTQTCWLQLPEF 172

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 222 RELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKplSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQA 301
Cdd:cd19352 173 REVGNYLKEKYHRALKVDLLQGAGNSAASRGAIAE--TFRSISKKELVHLEDSPDYCLENKTLGLLGTEGRECLKRGKAL 250

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 17505191 302 S-----GCDLMC--CGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTC 348
Cdd:cd19352 251 SkwekrSCRRLCgdCGLAVEERRAEMVSSCNCKFHWCCAVKCEQCRKTVTKYFC 304
Wnt_Wnt9a cd19353
Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, ...
 44-349 8.12e-75

Wnt domain found in protein Wnt-9a and similar proteins; Wnt-9a, also called protein Wnt-14, functions in the canonical Wnt/beta-catenin signaling pathway. It is required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Wnt-9a plays a redundant role in maintaining joint integrity. It is a conserved regulator of hematopoietic stem and progenitor cell development. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381727  Cd Length: 298  Bit Score: 233.00  E-value: 8.12e-75
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  44 LAPRQRAICQSRPDAIIVIGEGSQMGLDECQFQFRNGRWNCSALGERTvfGKELKVGSREAAFTYAIIAAGVAHAITAAC 123
Cdd:cd19353   1 LERKQRRMCRRDPGVAETLMEAISMSALECQYQFRFERWNCTLEGRYR--ASLLKRGFKETAFLYAISSAGLTHAMAKAC 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 124 TQGNLSDCGCDKEKQgqYHRDEGWKWGGCSADIRYGIGFAKVFVdAREIKQNARTLMNLHNNEAGRKILEENMKLECKCH 203
Cdd:cd19353  79 SAGRMERCTCDEAPD--LENREAWQWGGCGDNLKYSNKFVKEFL-GRKSSKDLRARVDFHNNLVGIKVIKAGVETTCKCH 155

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 204 GVSGSCTTKTCWTTLPQFRELGYVLKDKYNEAVHVEPVRASRNKRPTFLKIKKPL---SYRKPMDTDLVYIEKSPNYCEE 280
Cdd:cd19353 156 GVSGSCTVRTCWRQLSPFHEIGKQLKQKYETSLKVGSTTNEATGEGDISPPKKSGaghSDQIPRTTDLVYIDDSPSFCLM 235

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 17505191 281 DPVtgSVGTQGRACNKTapqaSGCDLMCCGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTCK 349
Cdd:cd19353 236 SRF--SPGTSGRRCYKD----KNCESICCGRGHNTQSRVVTRPCQCQVRWCCYVECKQCTQREEVYTCK 298
Wnt_Wnt8a cd19351
Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, ...
 65-348 5.27e-73

Wnt domain found in protein Wnt-8a and similar proteins; Wnt-8a, also called protein Wnt-8d, plays a role in embryonic patterning. Wnt genes have been identified in vertebrates and invertebrates, but not in plants, unicellular eukaryotes, or prokaryotes. In humans, 19 WNT proteins are known. Because of their insolubility little is known about Wnt protein structure, but all have 23 or 24 Cys residues whose spacing is highly conserved. Signal transduction by Wnt proteins (including the Wnt/beta-catenin, the Wnt/Ca++, and the Wnt/polarity pathway) is mediated by receptors of the Frizzled and LDL-receptor-related protein (LRP) families. The Wnt signaling mediated by Wnt proteins that orchestrate and influence a myriad of cellular processes, such as cell proliferation, differentiation, tumorigenesis, apoptosis, and participation in immune defense during microbe infection.


Pssm-ID: 381725  Cd Length: 307  Bit Score: 228.63  E-value: 5.27e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191  65 GSQMGLDECQFQFRNGRWNCSALGERTVFGKELKVGSREAAFTYAIIAAGVAHAITAACTQGNLSDCGCDKEKQGQYHrD 144
Cdd:cd19351  16 GAQSGIEECKHQFAWERWNCPESALQLSTHNGLRSATRETSFVHAISSAGVMYTLTRNCSLGDFENCGCDDSRNGRTG-G 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 145 EGWKWGGCSADIRYGIGFAKVFVDAREIKQNARTLMNLHNNEAGRKILEENMKLECKCHGVSGSCTTKTCWTTLPQFREL 224
Cdd:cd19351  95 RGWIWGGCSDNVEFGERISKQFVDALETGQDARALMNLHNNEAGRLAVKATMKRTCKCHGVSGSCSIQTCWLQLADFREI 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 17505191 225 GYVLKDKYNEAVHVE-PVRASRNKRPTFLKIKKPLSYRKPMDTDLVYIEKSPNYCEEDPVTGSVGTQGRACNKTAPQAS- 302
Cdd:cd19351 175 GNYLKVKHDQALKLEmDKRRMRAGNSADNRGAIAEAFGSVAETELIYLEDSPDYCTKNASLGLQGTEGRECLQSGKNLSq 254

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|..
gi 17505191 303 ----GCDLMC--CGRGYNTHQYARVWQCNCKFHWCCYVKCNTCSERTEMYTC 348
Cdd:cd19351 255 werrSCRRLCteCGLRVEERRTEVVSSCNCKFHWCCTVKCEQCRQVVTKHYC 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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