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Conserved domains on  [gi|19923268|ref|NP_004696|]
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52 kDa repressor of the inhibitor of the protein kinase [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-86 7.13e-23

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


:

Pssm-ID: 461662  Cd Length: 76  Bit Score: 92.98  E-value: 7.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923268     5 CAAPNCT-RKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKtpdqlnKHYRLCAKHFETSMICRtSPYRTVLRDNAIP 83
Cdd:pfam05485   1 CSVPGCTnRKKKNPRTSFHKFPKDPERRKKWLNACKRKDLPPP------SNSYVCSLHFEENDFEK-SGGKRKLKPGAIP 73


                  ...
gi 19923268    84 TIF 86
Cdd:pfam05485  74 TLF 76
DUF4371 super family cl46273
Domain of unknown function (DUF4371);
157-330 7.98e-14

Domain of unknown function (DUF4371);


The actual alignment was detected with superfamily member pfam14291:

Pssm-ID: 480613  Cd Length: 236  Bit Score: 71.88  E-value: 7.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923268   157 LEEKENKEYLKSLFEILILMGKQNIPLDGHEADEIPeglFTPDNFQALLecRINSG-EEVLRKRFETTAVNTLFCSKTQQ 235
Cdd:pfam14291  56 LEKNDYRIWLKASIDIIIHLLHQGLPLRGHDESEES---TNKGLFVELL--KYTAGqDEVVKKVLKNAPKNNTYTSPPIQ 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923268   236 RQMLEICESCIREETLREVrDSHFFSIITDDVVDIAGEEHLPVLVRFVDESHNLREEFIGFLPYEADAEILAVKFHTMIT 315
Cdd:pfam14291 131 NDIVNCFSNEVTRSIIEEM-DNDVFGILVDETADASDKEQMAIVFRYVDKYGVPIERFIGVIHVQETSSLSLKSAIDSLL 209

                         170
                  ....*....|....*
gi 19923268   316 EKWGLNMEYCRGQAY 330
Cdd:pfam14291 210 KSLGISLKKLRSQCY 224
Dimer_Tnp_hAT super family cl05324
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 672-729 4.81e-07

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


The actual alignment was detected with superfamily member pfam05699:

Pssm-ID: 399013  Cd Length: 83  Bit Score: 48.03  E-value: 4.81e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 19923268   672 KFFPNVYALLKVLCILPVMKVENERYENGRKRLkaYLRNTLTDQRSSNLALLNINFDI 729
Cdd:pfam05699  28 SRYPNLSKLARDILSIPVSSAASERSFSTLGKV--ILESRNRLEPLNVEALLCIEDWL 83
 
Name Accession Description Interval E-value
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-86 7.13e-23

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 92.98  E-value: 7.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923268     5 CAAPNCT-RKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKtpdqlnKHYRLCAKHFETSMICRtSPYRTVLRDNAIP 83
Cdd:pfam05485   1 CSVPGCTnRKKKNPRTSFHKFPKDPERRKKWLNACKRKDLPPP------SNSYVCSLHFEENDFEK-SGGKRKLKPGAIP 73


                  ...
gi 19923268    84 TIF 86
Cdd:pfam05485  74 TLF 76
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 5-87 2.46e-21

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 88.65  E-value: 2.46e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923268      5 CAAPNCTRKSTQ-SDLAFFRFPR-DPARCQKWVENCRRADLEDKTPdqlNKHYRLCAKHFETSMICRtspYRTVLRDNAI 82
Cdd:smart00980   2 CCVPGCGNRSKKnPGLSFFRFPKeDPELRKKWLENLGLPDDPNRKP---KKRSRICSRHFEPDDFDN---SGRRLKPGAV 75


                   ....*
gi 19923268     83 PTIFD 87
Cdd:smart00980  76 PTLFL 80
DUF4371 pfam14291
Domain of unknown function (DUF4371);
157-330 7.98e-14

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 71.88  E-value: 7.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923268   157 LEEKENKEYLKSLFEILILMGKQNIPLDGHEADEIPeglFTPDNFQALLecRINSG-EEVLRKRFETTAVNTLFCSKTQQ 235
Cdd:pfam14291  56 LEKNDYRIWLKASIDIIIHLLHQGLPLRGHDESEES---TNKGLFVELL--KYTAGqDEVVKKVLKNAPKNNTYTSPPIQ 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923268   236 RQMLEICESCIREETLREVrDSHFFSIITDDVVDIAGEEHLPVLVRFVDESHNLREEFIGFLPYEADAEILAVKFHTMIT 315
Cdd:pfam14291 131 NDIVNCFSNEVTRSIIEEM-DNDVFGILVDETADASDKEQMAIVFRYVDKYGVPIERFIGVIHVQETSSLSLKSAIDSLL 209

                         170
                  ....*....|....*
gi 19923268   316 EKWGLNMEYCRGQAY 330
Cdd:pfam14291 210 KSLGISLKKLRSQCY 224
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 672-729 4.81e-07

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 48.03  E-value: 4.81e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 19923268   672 KFFPNVYALLKVLCILPVMKVENERYENGRKRLkaYLRNTLTDQRSSNLALLNINFDI 729
Cdd:pfam05699  28 SRYPNLSKLARDILSIPVSSAASERSFSTLGKV--ILESRNRLEPLNVEALLCIEDWL 83
 
Name Accession Description Interval E-value
THAP pfam05485
THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a ...
 5-86 7.13e-23

THAP domain; The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion. It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 461662  Cd Length: 76  Bit Score: 92.98  E-value: 7.13e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923268     5 CAAPNCT-RKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKtpdqlnKHYRLCAKHFETSMICRtSPYRTVLRDNAIP 83
Cdd:pfam05485   1 CSVPGCTnRKKKNPRTSFHKFPKDPERRKKWLNACKRKDLPPP------SNSYVCSLHFEENDFEK-SGGKRKLKPGAIP 73


                  ...
gi 19923268    84 TIF 86
Cdd:pfam05485  74 TLF 76
THAP smart00980
The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It ...
 5-87 2.46e-21

The THAP domain is a putative DNA-binding domain (DBD) and probably also binds a zinc ion; It features the conserved C2CH architecture (consensus sequence: Cys - 2-4 residues - Cys - 35-50 residues - Cys - 2 residues - His). Other universal features include the location of the domain at the N-termini of proteins, its size of about 90 residues, a C-terminal AVPTIF box and several other conserved residues. Orthologues of the human THAP domain have been identified in other vertebrates and probably worms and flies, but not in other eukaryotes or any prokaryotes.


Pssm-ID: 214951  Cd Length: 80  Bit Score: 88.65  E-value: 2.46e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923268      5 CAAPNCTRKSTQ-SDLAFFRFPR-DPARCQKWVENCRRADLEDKTPdqlNKHYRLCAKHFETSMICRtspYRTVLRDNAI 82
Cdd:smart00980   2 CCVPGCGNRSKKnPGLSFFRFPKeDPELRKKWLENLGLPDDPNRKP---KKRSRICSRHFEPDDFDN---SGRRLKPGAV 75


                   ....*
gi 19923268     83 PTIFD 87
Cdd:smart00980  76 PTLFL 80
DM3 smart00692
Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;
21-86 4.51e-15

Zinc finger domain in CG10631, C. elegans LIN-15B and human P52rIPK;


Pssm-ID: 128933  Cd Length: 59  Bit Score: 70.03  E-value: 4.51e-15
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 19923268     21 FFRFPRDPARCQKWVENCRRADLEDKtpdqlNKHYRLCAKHFETSMICRtspyRTVLRDNAIPTIF 86
Cdd:smart00692   1 LFRFPKDPELLKKWEHNLRLSPDEKK-----LKNSRICSRHFEPECFGK----RRRLKPGAVPTLE 57
DUF4371 pfam14291
Domain of unknown function (DUF4371);
157-330 7.98e-14

Domain of unknown function (DUF4371);


Pssm-ID: 405048  Cd Length: 236  Bit Score: 71.88  E-value: 7.98e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923268   157 LEEKENKEYLKSLFEILILMGKQNIPLDGHEADEIPeglFTPDNFQALLecRINSG-EEVLRKRFETTAVNTLFCSKTQQ 235
Cdd:pfam14291  56 LEKNDYRIWLKASIDIIIHLLHQGLPLRGHDESEES---TNKGLFVELL--KYTAGqDEVVKKVLKNAPKNNTYTSPPIQ 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 19923268   236 RQMLEICESCIREETLREVrDSHFFSIITDDVVDIAGEEHLPVLVRFVDESHNLREEFIGFLPYEADAEILAVKFHTMIT 315
Cdd:pfam14291 131 NDIVNCFSNEVTRSIIEEM-DNDVFGILVDETADASDKEQMAIVFRYVDKYGVPIERFIGVIHVQETSSLSLKSAIDSLL 209

                         170
                  ....*....|....*
gi 19923268   316 EKWGLNMEYCRGQAY 330
Cdd:pfam14291 210 KSLGISLKKLRSQCY 224
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 672-729 4.81e-07

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 48.03  E-value: 4.81e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 19923268   672 KFFPNVYALLKVLCILPVMKVENERYENGRKRLkaYLRNTLTDQRSSNLALLNINFDI 729
Cdd:pfam05699  28 SRYPNLSKLARDILSIPVSSAASERSFSTLGKV--ILESRNRLEPLNVEALLCIEDWL 83
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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