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Conserved domains on  [gi|4759258|ref|NP_004720|]
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E3 SUMO-protein ligase ZBED1 [Homo sapiens]

Protein Classification

zf-BED and Dimer_Tnp_hAT domain-containing protein( domain architecture ID 10502541)

protein containing domains zf-BED, DUF4413, and Dimer_Tnp_hAT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 571-650 2.73e-16

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


:

Pssm-ID: 399013  Cd Length: 83  Bit Score: 74.22  E-value: 2.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759258    571 ELSNFKSQKVLGLNE--DPLKWWSDRLALFPLLPKVLQKYWCVTATRVAPERLFGSAANVVSAKRNRLAPAHVDEQVFLY 648
Cdd:pfam05699   1 ELDQYLSEPVLPRNEdfDPLEWWKENSSRYPNLSKLARDILSIPVSSAASERSFSTLGKVILESRNRLEPLNVEALLCIE 80


                  ..
gi 4759258    649 EN 650
Cdd:pfam05699  81 DW 82
zf-BED pfam02892
BED zinc finger;
23-72 3.13e-14

BED zinc finger;


:

Pssm-ID: 427043  Cd Length: 44  Bit Score: 67.01  E-value: 3.13e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 4759258     23 SKVWKYFGFdtnaegCILQWKKIYCRICMAQIAYSGNTSNLSYHLEKNHP 72
Cdd:pfam02892   1 SKVWKYFRE------LPLDETKAVCRYCGKILSRGGGTSNLIRHLRRKHP 44
DUF4413 super family cl16834
Domain of unknown function (DUF4413); This domain is part of an RNase-H fold section of longer ...
 412-511 2.82e-03

Domain of unknown function (DUF4413); This domain is part of an RNase-H fold section of longer proteins some of which are transposable elements possibly of the Pong type, since some members are putative Tam3 transposases.


The actual alignment was detected with superfamily member pfam14372:

Pssm-ID: 433913  Cd Length: 100  Bit Score: 37.61  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759258    412 SASRYPTISMVkplLHMLL--NTTLNiKETDSKELSMAKevIAKELSKTYQE-TPEIDMFLNVATFLDPRYKRLPFLSAF 488
Cdd:pfam14372   1 SGSKYPTANLY---FHEVWkiQLLLN-EWSLSDDPFISS--MAKKMQEKFDKyWRECNLVLAIAVVLDPRFKMKLVEFTF 74

                          90       100
                  ....*....|....*....|...
gi 4759258    489 ERQQVENrvveeAKGLLDKVKDG 511
Cdd:pfam14372  75 NKIYGED-----AKKYIKKVRDG 92
 
Name Accession Description Interval E-value
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 571-650 2.73e-16

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 74.22  E-value: 2.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759258    571 ELSNFKSQKVLGLNE--DPLKWWSDRLALFPLLPKVLQKYWCVTATRVAPERLFGSAANVVSAKRNRLAPAHVDEQVFLY 648
Cdd:pfam05699   1 ELDQYLSEPVLPRNEdfDPLEWWKENSSRYPNLSKLARDILSIPVSSAASERSFSTLGKVILESRNRLEPLNVEALLCIE 80


                  ..
gi 4759258    649 EN 650
Cdd:pfam05699  81 DW 82
zf-BED pfam02892
BED zinc finger;
23-72 3.13e-14

BED zinc finger;


Pssm-ID: 427043  Cd Length: 44  Bit Score: 67.01  E-value: 3.13e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 4759258     23 SKVWKYFGFdtnaegCILQWKKIYCRICMAQIAYSGNTSNLSYHLEKNHP 72
Cdd:pfam02892   1 SKVWKYFRE------LPLDETKAVCRYCGKILSRGGGTSNLIRHLRRKHP 44
ZnF_BED smart00614
BED zinc finger; DNA-binding domain in chromatin-boundary-element-binding proteins and ...
 24-74 6.04e-07

BED zinc finger; DNA-binding domain in chromatin-boundary-element-binding proteins and transposases


Pssm-ID: 214746 [Multi-domain]  Cd Length: 50  Bit Score: 46.65  E-value: 6.04e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 4759258      24 KVWKYFGFDTNAEGcilQWKKIYCRICMAQIAYSGN--TSNLSYHLEKNHPEE 74
Cdd:smart00614   1 KVWKHFTLILEKDN---GKQRAKCKYCGKKLSRSSKggTSNLRRHLRRKHPAR 50
DUF4413 pfam14372
Domain of unknown function (DUF4413); This domain is part of an RNase-H fold section of longer ...
 412-511 2.82e-03

Domain of unknown function (DUF4413); This domain is part of an RNase-H fold section of longer proteins some of which are transposable elements possibly of the Pong type, since some members are putative Tam3 transposases.


Pssm-ID: 433913  Cd Length: 100  Bit Score: 37.61  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759258    412 SASRYPTISMVkplLHMLL--NTTLNiKETDSKELSMAKevIAKELSKTYQE-TPEIDMFLNVATFLDPRYKRLPFLSAF 488
Cdd:pfam14372   1 SGSKYPTANLY---FHEVWkiQLLLN-EWSLSDDPFISS--MAKKMQEKFDKyWRECNLVLAIAVVLDPRFKMKLVEFTF 74

                          90       100
                  ....*....|....*....|...
gi 4759258    489 ERQQVENrvveeAKGLLDKVKDG 511
Cdd:pfam14372  75 NKIYGED-----AKKYIKKVRDG 92
 
Name Accession Description Interval E-value
Dimer_Tnp_hAT pfam05699
hAT family C-terminal dimerization region; This dimerization region is found at the C terminus ...
 571-650 2.73e-16

hAT family C-terminal dimerization region; This dimerization region is found at the C terminus of the transposases of elements belonging to the Activator superfamily (hAT element superfamily). The isolated dimerization region forms extremely stable dimers in vitro.


Pssm-ID: 399013  Cd Length: 83  Bit Score: 74.22  E-value: 2.73e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759258    571 ELSNFKSQKVLGLNE--DPLKWWSDRLALFPLLPKVLQKYWCVTATRVAPERLFGSAANVVSAKRNRLAPAHVDEQVFLY 648
Cdd:pfam05699   1 ELDQYLSEPVLPRNEdfDPLEWWKENSSRYPNLSKLARDILSIPVSSAASERSFSTLGKVILESRNRLEPLNVEALLCIE 80


                  ..
gi 4759258    649 EN 650
Cdd:pfam05699  81 DW 82
zf-BED pfam02892
BED zinc finger;
23-72 3.13e-14

BED zinc finger;


Pssm-ID: 427043  Cd Length: 44  Bit Score: 67.01  E-value: 3.13e-14
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 4759258     23 SKVWKYFGFdtnaegCILQWKKIYCRICMAQIAYSGNTSNLSYHLEKNHP 72
Cdd:pfam02892   1 SKVWKYFRE------LPLDETKAVCRYCGKILSRGGGTSNLIRHLRRKHP 44
ZnF_BED smart00614
BED zinc finger; DNA-binding domain in chromatin-boundary-element-binding proteins and ...
 24-74 6.04e-07

BED zinc finger; DNA-binding domain in chromatin-boundary-element-binding proteins and transposases


Pssm-ID: 214746 [Multi-domain]  Cd Length: 50  Bit Score: 46.65  E-value: 6.04e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 4759258      24 KVWKYFGFDTNAEGcilQWKKIYCRICMAQIAYSGN--TSNLSYHLEKNHPEE 74
Cdd:smart00614   1 KVWKHFTLILEKDN---GKQRAKCKYCGKKLSRSSKggTSNLRRHLRRKHPAR 50
DUF4413 pfam14372
Domain of unknown function (DUF4413); This domain is part of an RNase-H fold section of longer ...
 412-511 2.82e-03

Domain of unknown function (DUF4413); This domain is part of an RNase-H fold section of longer proteins some of which are transposable elements possibly of the Pong type, since some members are putative Tam3 transposases.


Pssm-ID: 433913  Cd Length: 100  Bit Score: 37.61  E-value: 2.82e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4759258    412 SASRYPTISMVkplLHMLL--NTTLNiKETDSKELSMAKevIAKELSKTYQE-TPEIDMFLNVATFLDPRYKRLPFLSAF 488
Cdd:pfam14372   1 SGSKYPTANLY---FHEVWkiQLLLN-EWSLSDDPFISS--MAKKMQEKFDKyWRECNLVLAIAVVLDPRFKMKLVEFTF 74

                          90       100
                  ....*....|....*....|...
gi 4759258    489 ERQQVENrvveeAKGLLDKVKDG 511
Cdd:pfam14372  75 NKIYGED-----AKKYIKKVRDG 92
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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