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Conserved domains on  [gi|4758062|ref|NP_004741|]
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cytokine receptor-like factor 1 precursor [Homo sapiens]

Protein Classification

Lep_receptor_Ig and FN3 domain-containing protein( domain architecture ID 10272913)

Lep_receptor_Ig and FN3 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 super family cl21522
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 133-228 1.87e-17

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


The actual alignment was detected with superfamily member pfam09067:

Pssm-ID: 473895  Cd Length: 104  Bit Score: 77.46  E-value: 1.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062    133 LPPEKPVNISCWSKNMKDLTCRWTPGAhgETFLHTNYSLKYklrWYGQDNT--CEEYHTVGPHS-----CHIPK-DLALF 204
Cdd:pfam09067   6 LLPEKPEDIKCFSREKEDFTCFWEEEE--DGGLPTTYSFSY---AYENETVkeCPLYSTSGANStrlfiCFFPKnDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 4758062    205 TPYEIWVEATNRLGSARSDVLTLD 228
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 236-338 6.75e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.05  E-value: 6.75e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062  236 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFqaKYQIRYRVEDSVDWKVVD-DVSNQTSCRLAGLKPGTVYFVQVRCn 314
Cdd:cd00063   2 SPPTNLRVTDVT--STSVTLSWTPPEDDGGPIT--GYVVEYREKGSGDWKEVEvTPGSETSYTLTGLKPGTEYEFRVRA- 76

                        90       100
                ....*....|....*....|....
gi 4758062  315 pfgiygsKKAGIWSEWSHPTAAST 338
Cdd:cd00063  77 -------VNGGGESPPSESVTVTT 93
Lep_receptor_Ig super family cl05692
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 41-104 2.39e-03

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


The actual alignment was detected with superfamily member pfam06328:

Pssm-ID: 461878  Cd Length: 87  Bit Score: 36.84  E-value: 2.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4758062     41 AVISPQDPTLLIGSSLLATCSVHGDPP---GATAEGLYWTLNGRRLPPELSRVLNASTLALALANLN 104
Cdd:pfam06328   4 GHISPSPPVVRLGSNVTASCILKENCCshlGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLN 70
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 133-228 1.87e-17

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 77.46  E-value: 1.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062    133 LPPEKPVNISCWSKNMKDLTCRWTPGAhgETFLHTNYSLKYklrWYGQDNT--CEEYHTVGPHS-----CHIPK-DLALF 204
Cdd:pfam09067   6 LLPEKPEDIKCFSREKEDFTCFWEEEE--DGGLPTTYSFSY---AYENETVkeCPLYSTSGANStrlfiCFFPKnDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 4758062    205 TPYEIWVEATNRLGSARSDVLTLD 228
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 236-338 6.75e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.05  E-value: 6.75e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062  236 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFqaKYQIRYRVEDSVDWKVVD-DVSNQTSCRLAGLKPGTVYFVQVRCn 314
Cdd:cd00063   2 SPPTNLRVTDVT--STSVTLSWTPPEDDGGPIT--GYVVEYREKGSGDWKEVEvTPGSETSYTLTGLKPGTEYEFRVRA- 76

                        90       100
                ....*....|....*....|....
gi 4758062  315 pfgiygsKKAGIWSEWSHPTAAST 338
Cdd:cd00063  77 -------VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 236-318 2.60e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 2.60e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062     236 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFQAKYQIRYRvEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRC-N 314
Cdd:smart00060   2 SPPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYR-EEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAvN 78


                   ....
gi 4758062     315 PFGI 318
Cdd:smart00060  79 GAGE 82
fn3 pfam00041
Fibronectin type III domain;
236-331 7.38e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 7.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062    236 DPPPDVHVSRVGglEDQLSVRWVSPPALK-DFLfqaKYQIRYRVEDSVD-WKVVDDVSNQTSCRLAGLKPGTVYFVQVRc 313
Cdd:pfam00041   1 SAPSNLTVTDVT--STSLTVSWTPPPDGNgPIT---GYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQ- 74

                          90
                  ....*....|....*...
gi 4758062    314 npfgiygSKKAGIWSEWS 331
Cdd:pfam00041  75 -------AVNGGGEGPPS 85
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
134-363 5.29e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.93  E-value: 5.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062  134 PPEKPVNISCWSKNMKDLTCRWTPgahgetflHTNYSLK-YKL-RWYGQDNTCEEYHTVgPHSCHIPKDLALFTPYEIWV 211
Cdd:COG3401 232 PPSAPTGLTATADTPGSVTLSWDP--------VTESDATgYRVyRSNSGDGPFTKVATV-TTTSYTDTGLTNGTTYYYRV 302

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062  212 EATNRLG--SARSDVLTLdILDVVTTDPPPDVHVSRVGGleDQLSVRWvSPPALKDFlfqAKYQIRYRVEDSVDWKVVDD 289
Cdd:COG3401 303 TAVDAAGneSAPSNVVSV-TTDLTPPAAPSGLTATAVGS--SSITLSW-TASSDADV---TGYNVYRSTSGGGTYTKIAE 375

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4758062  290 VSNQTSCRLAGLKPGTVYFVQVRC-NpfgiygskKAGIWSEWSHPTAASTPrSERPGPGGGACEPRGGEPSSGPV 363
Cdd:COG3401 376 TVTTTSYTDTGLTPGTTYYYKVTAvD--------AAGNESAPSEEVSATTA-SAASGESLTASVDAVPLTDVAGA 441
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 135-219 1.07e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.68  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062     135 PEKPVNISCWSKNMKDLTCRWTPGAHGEtflHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEAT 214
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG---ITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*
gi 4758062     215 NRLGS 219
Cdd:smart00060  78 NGAGE 82
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
207-312 6.05e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 42.24  E-value: 6.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062  207 YEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPAlkdfLFQAKYQIRYRVEDsvDW-- 284
Cdd:COG4733 599 YEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLTATGGLGGITLSWSFPVD----ADTLRTEIRYSTTG--DWas 672

                        90       100
                ....*....|....*....|....*....
gi 4758062  285 -KVVDDVSNQTSCRLAGLKPGTVYFVQVR 312
Cdd:COG4733 673 aTVAQALYPGNTYTLAGLKAGQTYYYRAR 701
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 41-104 2.39e-03

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 36.84  E-value: 2.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4758062     41 AVISPQDPTLLIGSSLLATCSVHGDPP---GATAEGLYWTLNGRRLPPELSRVLNASTLALALANLN 104
Cdd:pfam06328   4 GHISPSPPVVRLGSNVTASCILKENCCshlGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLN 70
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 135-226 3.06e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 3.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062  135 PEKPVNISCWSKNMKDLTCRWTPGAHGETFLhTNYSLKYKLRWYGQDNTCEEyHTVGPHSCHIpKDLALFTPYEIWVEAT 214
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYREKGSGDWKEVEV-TPGSETSYTL-TGLKPGTEYEFRVRAV 77

                        90
                ....*....|...
gi 4758062  215 NRLG-SARSDVLT 226
Cdd:cd00063  78 NGGGeSPPSESVT 90
 
Name Accession Description Interval E-value
EpoR_lig-bind pfam09067
Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin ...
 133-228 1.87e-17

Erythropoietin receptor, ligand binding; Members of this family interact with erythropoietin (EPO), with subsequent initiation of the downstream chain of events associated with binding of EPO to the receptor, including EPO-induced erythroblast proliferation and differentiation through induction of the JAK2/STAT5 signaling cascade. The domain adopts a secondary structure composed of a short amino-terminal helix, followed by two beta-sandwich regions.


Pssm-ID: 401127  Cd Length: 104  Bit Score: 77.46  E-value: 1.87e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062    133 LPPEKPVNISCWSKNMKDLTCRWTPGAhgETFLHTNYSLKYklrWYGQDNT--CEEYHTVGPHS-----CHIPK-DLALF 204
Cdd:pfam09067   6 LLPEKPEDIKCFSREKEDFTCFWEEEE--DGGLPTTYSFSY---AYENETVkeCPLYSTSGANStrlfiCFFPKnDVSLF 80

                          90       100
                  ....*....|....*....|....
gi 4758062    205 TPYEIWVEATNRLGSARSDVLTLD 228
Cdd:pfam09067  81 VPLHITVVATNTNGTRYSRELSVE 104
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 236-338 6.75e-13

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 64.05  E-value: 6.75e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062  236 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFqaKYQIRYRVEDSVDWKVVD-DVSNQTSCRLAGLKPGTVYFVQVRCn 314
Cdd:cd00063   2 SPPTNLRVTDVT--STSVTLSWTPPEDDGGPIT--GYVVEYREKGSGDWKEVEvTPGSETSYTLTGLKPGTEYEFRVRA- 76

                        90       100
                ....*....|....*....|....
gi 4758062  315 pfgiygsKKAGIWSEWSHPTAAST 338
Cdd:cd00063  77 -------VNGGGESPPSESVTVTT 93
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 236-318 2.60e-12

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 62.25  E-value: 2.60e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062     236 DPPPDVHVSRVGglEDQLSVRWVSPPALKDFLFQAKYQIRYRvEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFVQVRC-N 314
Cdd:smart00060   2 SPPSNLRVTDVT--STSVTLSWEPPPDDGITGYIVGYRVEYR-EEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAvN 78


                   ....
gi 4758062     315 PFGI 318
Cdd:smart00060  79 GAGE 82
fn3 pfam00041
Fibronectin type III domain;
236-331 7.38e-11

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 58.20  E-value: 7.38e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062    236 DPPPDVHVSRVGglEDQLSVRWVSPPALK-DFLfqaKYQIRYRVEDSVD-WKVVDDVSNQTSCRLAGLKPGTVYFVQVRc 313
Cdd:pfam00041   1 SAPSNLTVTDVT--STSLTVSWTPPPDGNgPIT---GYEVEYRPKNSGEpWNEITVPGTTTSVTLTGLKPGTEYEVRVQ- 74

                          90
                  ....*....|....*...
gi 4758062    314 npfgiygSKKAGIWSEWS 331
Cdd:pfam00041  75 -------AVNGGGEGPPS 85
Pur_ac_phosph_N pfam16656
Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple ...
 238-332 8.32e-08

Purple acid Phosphatase, N-terminal domain; This domain is found at the N-terminus of Purple acid phosphatase proteins.


Pssm-ID: 465220 [Multi-domain]  Cd Length: 93  Bit Score: 49.72  E-value: 8.32e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062    238 PPDVHVSrVGGLEDQLSVRWVSPPALKDflfqakYQIRYRVEDSVDWKVV-----------DDVSNQTSCRLAGLKPGTV 306
Cdd:pfam16656   1 PEQVHLS-LTGDSTSMTVSWVTPSAVTS------PVVQYGTSSSALTSTAtatsstyttgdGGTGYIHRATLTGLEPGTT 73

                          90       100
                  ....*....|....*....|....*.
gi 4758062    307 YFVQVRCnpfgiygskKAGIWSEWSH 332
Cdd:pfam16656  74 YYYRVGD---------DNGGWSEVYS 90
ObR_Ig pfam18589
Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) ...
 138-222 2.97e-07

Obesity receptor immunoglobulin like domain; This is the immunoglobulin-like domain (IGD) found in obesity receptors (ObR). ObR is a single membrane-spanning receptor belonging to the class I cytokine receptor family. All isoforms have an identical extracellular part consisting of six domains: an N-terminal domain (NTD), two CRH domains (CRH1 and CRH2), an immunoglobulin-like domain (IGD), and two additional membrane-proximal fibronectin type III (FN III) domains. ObR activation depends on the CRH2, IGD, and FN III domains, however the CRH2 domain is the major leptin-binding determinant in the receptor. The IGD and membrane-proximal domains have no detectable affinity for the ligand, but are nonetheless indispensable for receptor activation. Deletion of the IGD results in a receptor with wild-type affinity for leptin, but completely devoid of biological activity.


Pssm-ID: 465812  Cd Length: 105  Bit Score: 48.50  E-value: 2.97e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062    138 PVNISCWSK-NMKDLTCRWTPgahgeTFLHTNYSLKYKLRWYGQDNTCEEYHTVGP----------------HSCHIPKd 200
Cdd:pfam18589   1 NWNISCETNgDLDLMTCRWNT-----TKWSLLADSKVNLRYRRSELSCEDRSTSSLkggsmvkecdcqgpgfYECTIQP- 74

                          90       100
                  ....*....|....*....|..
gi 4758062    201 LALFTPYEIWVEATNRLGSARS 222
Cdd:pfam18589  75 LYLNSTYIMWLEISHGLGPLQS 96
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
134-363 5.29e-07

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 51.93  E-value: 5.29e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062  134 PPEKPVNISCWSKNMKDLTCRWTPgahgetflHTNYSLK-YKL-RWYGQDNTCEEYHTVgPHSCHIPKDLALFTPYEIWV 211
Cdd:COG3401 232 PPSAPTGLTATADTPGSVTLSWDP--------VTESDATgYRVyRSNSGDGPFTKVATV-TTTSYTDTGLTNGTTYYYRV 302

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062  212 EATNRLG--SARSDVLTLdILDVVTTDPPPDVHVSRVGGleDQLSVRWvSPPALKDFlfqAKYQIRYRVEDSVDWKVVDD 289
Cdd:COG3401 303 TAVDAAGneSAPSNVVSV-TTDLTPPAAPSGLTATAVGS--SSITLSW-TASSDADV---TGYNVYRSTSGGGTYTKIAE 375

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4758062  290 VSNQTSCRLAGLKPGTVYFVQVRC-NpfgiygskKAGIWSEWSHPTAASTPrSERPGPGGGACEPRGGEPSSGPV 363
Cdd:COG3401 376 TVTTTSYTDTGLTPGTTYYYKVTAvD--------AAGNESAPSEEVSATTA-SAASGESLTASVDAVPLTDVAGA 441
Interfer-bind pfam09294
Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary ...
 238-330 5.38e-06

Interferon-alpha/beta receptor, fibronectin type III; Members of this family adopt a secondary structure consisting of seven beta-strands arranged in an immunoglobulin-like beta-sandwich, in a Greek-key topology. They are required for binding to interferon-alpha.


Pssm-ID: 462746  Cd Length: 103  Bit Score: 45.03  E-value: 5.38e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062    238 PPDVHVSRVGgleDQLSVRwVSPPA--------LKDFLFQAKYQIRYRvEDSVDWKVVDDVSNQTSCRLAGLKPGTVYFV 309
Cdd:pfam09294   5 PPEVELEVEG---GSLNVT-VKDPEtregknlsLRDLYGSLQYRVSYW-KNSSNGEKKNTTSTNSFVVLSDLEPGTTYCV 79

                          90       100
                  ....*....|....*....|.
gi 4758062    310 QVRcnpFGIYGSKKAGIWSEW 330
Cdd:pfam09294  80 SVQ---AFSPLDNKSSQRSPP 97
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 135-219 1.07e-04

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 40.68  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062     135 PEKPVNISCWSKNMKDLTCRWTPGAHGEtflHTNYSLKYKLRWYGQDNTCEEYHTVGPHSCHIPKDLALFTPYEIWVEAT 214
Cdd:smart00060   1 PSPPSNLRVTDVTSTSVTLSWEPPPDDG---ITGYIVGYRVEYREEGSEWKEVNVTPSSTSYTLTGLKPGTEYEFRVRAV 77


                   ....*
gi 4758062     215 NRLGS 219
Cdd:smart00060  78 NGAGE 82
COG4733 COG4733
Phage-related protein, tail protein J [Mobilome: prophages, transposons];
207-312 6.05e-04

Phage-related protein, tail protein J [Mobilome: prophages, transposons];


Pssm-ID: 443767 [Multi-domain]  Cd Length: 978  Bit Score: 42.24  E-value: 6.05e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062  207 YEIWVEATNRLGSARSDVLTLDILDVVTTDPPPDVHVSRVGGLEDQLSVRWVSPPAlkdfLFQAKYQIRYRVEDsvDW-- 284
Cdd:COG4733 599 YEVRVRAINALGVSSAWAASSETTVTGKTAPPPAPTGLTATGGLGGITLSWSFPVD----ADTLRTEIRYSTTG--DWas 672

                        90       100
                ....*....|....*....|....*....
gi 4758062  285 -KVVDDVSNQTSCRLAGLKPGTVYFVQVR 312
Cdd:COG4733 673 aTVAQALYPGNTYTLAGLKAGQTYYYRAR 701
Lep_receptor_Ig pfam06328
Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two ...
 41-104 2.39e-03

Ig-like C2-type domain; This domain is a ligand-binding immunoglobulin-like domain. The two cysteine residues form a disulphide bridge.


Pssm-ID: 461878  Cd Length: 87  Bit Score: 36.84  E-value: 2.39e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4758062     41 AVISPQDPTLLIGSSLLATCSVHGDPP---GATAEGLYWTLNGRRLPPELSRVLNASTLALALANLN 104
Cdd:pfam06328   4 GHISPSPPVVRLGSNVTASCILKENCCshlGVEAQIIVWKLGLELIPGSQYTVLNDTVSSVTLPNLN 70
FN3 COG3401
Fibronectin type 3 domain [General function prediction only];
200-346 2.45e-03

Fibronectin type 3 domain [General function prediction only];


Pssm-ID: 442628 [Multi-domain]  Cd Length: 603  Bit Score: 39.99  E-value: 2.45e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062  200 DLALFTPYEIWVEATNRLG-SARSDVLTLDildVVTTDPPPDVHVSRVGGLEDQLSVRWvSPPALKDFlfqAKYQIRYRV 278
Cdd:COG3401 198 DIEPGTTYYYRVAATDTGGeSAPSNEVSVT---TPTTPPSAPTGLTATADTPGSVTLSW-DPVTESDA---TGYRVYRSN 270

                        90       100       110       120       130       140
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 4758062  279 EDSVDWKVVDDVsNQTSCRLAGLKPGTVYFVQVRCnpfgiygSKKAGIWSEWShPTAASTPRSERPGP 346
Cdd:COG3401 271 SGDGPFTKVATV-TTTSYTDTGLTNGTTYYYRVTA-------VDAAGNESAPS-NVVSVTTDLTPPAA 329
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 135-226 3.06e-03

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 36.71  E-value: 3.06e-03
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062  135 PEKPVNISCWSKNMKDLTCRWTPGAHGETFLhTNYSLKYKLRWYGQDNTCEEyHTVGPHSCHIpKDLALFTPYEIWVEAT 214
Cdd:cd00063   1 PSPPTNLRVTDVTSTSVTLSWTPPEDDGGPI-TGYVVEYREKGSGDWKEVEV-TPGSETSYTL-TGLKPGTEYEFRVRAV 77

                        90
                ....*....|...
gi 4758062  215 NRLG-SARSDVLT 226
Cdd:cd00063  78 NGGGeSPPSESVT 90
IL6Ra-bind pfam09240
Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure ...
 140-222 4.17e-03

Interleukin-6 receptor alpha chain, binding; Members of this family adopt a structure consisting of an immunoglobulin-like beta-sandwich, with seven strands in two beta-sheets, in a Greek-key topology. They are required for binding to the cytokine Interleukin-6.


Pssm-ID: 401252  Cd Length: 96  Bit Score: 36.62  E-value: 4.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4758062    140 NISCWSKNMKDLTCRWTPGAhgETFLHTNYSLKYklrWYGQ-DNT--CEEYH-TVGPH-SCHIPKDLALFTPYE---IWV 211
Cdd:pfam09240   1 DLTCFIHNPSNLSCEWKPGP--NAPPDTNYVLYV---RKSPlGPVlqCQYYIrDDGTRiGCQFDDLEGLSSSFHqvyICV 75

                          90
                  ....*....|.
gi 4758062    212 EATNRLGSARS 222
Cdd:pfam09240  76 NGSSSAGPIRS 86
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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