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Conserved domains on  [gi|4757988|ref|NP_004795|]
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probable cytosolic iron-sulfur protein assembly protein CIAO1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-332 4.16e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 227.99  E-value: 4.16e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988   17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988   97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988  177 YREEEddWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYlpgneqgvacsgsdpSWKCICTLSGfHSRTIY 256
Cdd:cd00200 162 WDLRT--GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------TGKCLGTLRG-HENGVN 223

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4757988  257 DIAWCQlTGALATACGDD-AIRVFqedpNSDPQQPTFSLtahlhQAHSQDVNCVAWNPkEPGLLASCSDDGEVAFWK 332
Cdd:cd00200 224 SVAFSP-DGYLLASGSEDgTIRVW----DLRTGECVQTL-----SGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-332 4.16e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 227.99  E-value: 4.16e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988   17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988   97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988  177 YREEEddWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYlpgneqgvacsgsdpSWKCICTLSGfHSRTIY 256
Cdd:cd00200 162 WDLRT--GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------TGKCLGTLRG-HENGVN 223

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4757988  257 DIAWCQlTGALATACGDD-AIRVFqedpNSDPQQPTFSLtahlhQAHSQDVNCVAWNPkEPGLLASCSDDGEVAFWK 332
Cdd:cd00200 224 SVAFSP-DGYLLASGSEDgTIRVW----DLRTGECVQTL-----SGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
7-331 1.43e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.77  E-value: 1.43e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988    7 LLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEgdSWICKSVLSeGHQRTVRKVAWSPCGNYLASASFDATTC 86
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988   87 IWkkNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLA 166
Cdd:COG2319 188 LW--DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSPDGRLLA 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988  167 SASYDDTVKLYREEEDDWVccATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQylpgneqgvacsgsdPSWKCICT 246
Cdd:COG2319 263 SGSADGTVRLWDLATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL---------------ATGKLLRT 325

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988  247 LSGfHSRTIYDIAWCQLTGALATACGDDAIRVFqeDPNSDPQQPTFsltahlhQAHSQDVNCVAWNPKEPgLLASCSDDG 326
Cdd:COG2319 326 LTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLW--DLATGELLRTL-------TGHTGAVTSVAFSPDGR-TLASGSADG 394


                ....*
gi 4757988  327 EVAFW 331
Cdd:COG2319 395 TVRLW 399
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-221 3.66e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 3.66e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4757988     183 DWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
184-221 1.18e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.18e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4757988    184 WVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00420 PTZ00420
coronin; Provisional
 22-123 6.04e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 6.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988    22 LAWNPA-GTLLASCGGDRRIRIWGTEGDSWICKSV-----LSEGHQRTVRKVAWSPCGNY-LASASFDATTCIW--KKNQ 92
Cdd:PTZ00420  80 LQFNPCfSEILASGSEDLTIRVWEIPHNDESVKEIkdpqcILKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIWdiENEK 159

                         90       100       110
                 ....*....|....*....|....*....|..
gi 4757988    93 DDFECVTTlegheNEVKSVAWAPSGNLLA-TC 123
Cdd:PTZ00420 160 RAFQINMP-----KKLSSLKWNIKGNLLSgTC 186
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 17-332 4.16e-73

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 227.99  E-value: 4.16e-73
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988   17 SRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSwiCKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWKKNQDdfE 96
Cdd:cd00200  10 GGVTCVAFSPDGKLLATGSGDGTIKVWDLETGE--LLRTL-KGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETG--E 84

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988   97 CVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVdeeDEYECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKL 176
Cdd:cd00200  85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDV---ETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988  177 YREEEddWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQYlpgneqgvacsgsdpSWKCICTLSGfHSRTIY 256
Cdd:cd00200 162 WDLRT--GKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLS---------------TGKCLGTLRG-HENGVN 223

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4757988  257 DIAWCQlTGALATACGDD-AIRVFqedpNSDPQQPTFSLtahlhQAHSQDVNCVAWNPkEPGLLASCSDDGEVAFWK 332
Cdd:cd00200 224 SVAFSP-DGYLLASGSEDgTIRVW----DLRTGECVQTL-----SGHTNSVTSLAWSP-DGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
7-331 1.43e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 209.77  E-value: 1.43e-64
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988    7 LLGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWGTEgdSWICKSVLSeGHQRTVRKVAWSPCGNYLASASFDATTC 86
Cdd:COG2319 111 LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--TGKLLRTLT-GHSGAVTSVAFSPDGKLLASGSDDGTVR 187

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988   87 IWkkNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLA 166
Cdd:COG2319 188 LW--DLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATG---KLLRTLTGHSGSVRSVAFSPDGRLLA 262

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988  167 SASYDDTVKLYREEEDDWVccATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQylpgneqgvacsgsdPSWKCICT 246
Cdd:COG2319 263 SGSADGTVRLWDLATGELL--RTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDL---------------ATGKLLRT 325

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988  247 LSGfHSRTIYDIAWCQLTGALATACGDDAIRVFqeDPNSDPQQPTFsltahlhQAHSQDVNCVAWNPKEPgLLASCSDDG 326
Cdd:COG2319 326 LTG-HTGAVRSVAFSPDGKTLASGSDDGTVRLW--DLATGELLRTL-------TGHTGAVTSVAFSPDGR-TLASGSADG 394


                ....*
gi 4757988  327 EVAFW 331
Cdd:COG2319 395 TVRLW 399
WD40 COG2319
WD40 repeat [General function prediction only];
7-280 1.09e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 191.66  E-value: 1.09e-57
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988    7 LLGRVPAHPDsRCWFLAWNPAGTLLASCGGDRRIRIWGTEGDSWIckSVLsEGHQRTVRKVAWSPCGNYLASASFDATTC 86
Cdd:COG2319 154 LLRTLTGHSG-AVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLL--RTL-TGHTGAVRSVAFSPDGKLLASGSADGTVR 229

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988   87 IWkkNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLA 166
Cdd:COG2319 230 LW--DLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATG---ELLRTLTGHSGGVNSVAFSPDGKLLA 304

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988  167 SASYDDTVKLYreEEDDWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRQylpgneqgvacsgsdPSWKCICT 246
Cdd:COG2319 305 SGSDDGTVRLW--DLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDL---------------ATGELLRT 367

                       250       260       270
                ....*....|....*....|....*....|....
gi 4757988  247 LSGfHSRTIYDIAWCQLTGALATACGDDAIRVFQ 280
Cdd:COG2319 368 LTG-HTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
23-331 6.75e-42

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 150.06  E-value: 6.75e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988   23 AWNPAGTLLASCGGDRRIRIWGTEGDSWIcksVLSEGHQRTVRKVAWSPCGNYLASASFDATTCIWkkNQDDFECVTTLE 102
Cdd:COG2319   1 ALSADGAALAAASADLALALLAAALGALL---LLLLGLAAAVASLAASPDGARLAAGAGDLTLLLL--DAAAGALLATLL 75

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988  103 GHENEVKSVAWAPSGNLLATCSRDKSVWVWEVDEEdeyECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLYreEED 182
Cdd:COG2319  76 GHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG---LLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLW--DLA 150

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988  183 DWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWrqylpgneqgvacsgSDPSWKCICTLSGfHSRTIYDIAWC- 261
Cdd:COG2319 151 TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLW---------------DLATGKLLRTLTG-HTGAVRSVAFSp 214

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4757988  262 --QLtgaLATACGDDAIRVFqedpNSDPQQPTFSLTahlhqAHSQDVNCVAWNPKEPgLLASCSDDGEVAFW 331
Cdd:COG2319 215 dgKL---LASGSADGTVRLW----DLATGKLLRTLT-----GHSGSVRSVAFSPDGR-LLASGSADGTVRLW 273
WD40 COG2319
WD40 repeat [General function prediction only];
8-135 2.14e-26

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 108.07  E-value: 2.14e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988    8 LGRVPAHPDSRCWFLAWNPAGTLLASCGGDRRIRIWgtEGDSWICKSVLSeGHQRTVRKVAWSPCGNYLASASFDATTCI 87
Cdd:COG2319 280 LLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLW--DLATGKLLRTLT-GHTGAVRSVAFSPDGKTLASGSDDGTVRL 356

                        90       100       110       120
                ....*....|....*....|....*....|....*....|....*...
gi 4757988   88 WkkNQDDFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWEVD 135
Cdd:COG2319 357 W--DLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLA 402
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 183-221 3.66e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 54.63  E-value: 3.66e-10
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 4757988     183 DWVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
184-221 1.18e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 53.12  E-value: 1.18e-09
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 4757988    184 WVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIW 221
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 94-133 2.37e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 52.31  E-value: 2.37e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4757988      94 DFECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
95-133 2.60e-08

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 49.27  E-value: 2.60e-08
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 4757988     95 FECVTTLEGHENEVKSVAWAPSGNLLATCSRDKSVWVWE 133
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 141-177 4.00e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 4.00e-06
                           10        20        30
                   ....*....|....*....|....*....|....*..
gi 4757988     141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
Cdd:smart00320   3 ELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
PTZ00420 PTZ00420
coronin; Provisional
 22-123 6.04e-06

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 48.02  E-value: 6.04e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988    22 LAWNPA-GTLLASCGGDRRIRIWGTEGDSWICKSV-----LSEGHQRTVRKVAWSPCGNY-LASASFDATTCIW--KKNQ 92
Cdd:PTZ00420  80 LQFNPCfSEILASGSEDLTIRVWEIPHNDESVKEIkdpqcILKGHKKKISIIDWNPMNYYiMCSSGFDSFVNIWdiENEK 159

                         90       100       110
                 ....*....|....*....|....*....|..
gi 4757988    93 DDFECVTTlegheNEVKSVAWAPSGNLLA-TC 123
Cdd:PTZ00420 160 RAFQINMP-----KKLSSLKWNIKGNLLSgTC 186
PTZ00420 PTZ00420
coronin; Provisional
 98-182 1.37e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.87  E-value: 1.37e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988    98 VTTLEGHENEVKSVAWAPS-GNLLATCSRDKSVWVWEVDEEDEY-------ECvsVLNSHTQDVKHVVWHP-SQELLASA 168
Cdd:PTZ00420  67 VIKLKGHTSSILDLQFNPCfSEILASGSEDLTIRVWEIPHNDESvkeikdpQC--ILKGHKKKISIIDWNPmNYYIMCSS 144

                         90
                 ....*....|....
gi 4757988   169 SYDDTVKLYREEED 182
Cdd:PTZ00420 145 GFDSFVNIWDIENE 158
PTZ00420 PTZ00420
coronin; Provisional
 190-260 1.61e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 46.48  E-value: 1.61e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4757988   190 LEGHESTVWSLAFDPS-GQRLASCSDDRTVRIWRqyLPGNEQGVAcSGSDPswkcICTLSGfHSRTIYDIAW 260
Cdd:PTZ00420  70 LKGHTSSILDLQFNPCfSEILASGSEDLTIRVWE--IPHNDESVK-EIKDP----QCILKG-HKKKISIIDW 133
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 49-89 3.51e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.37  E-value: 3.51e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 4757988      49 SWICKSVLsEGHQRTVRKVAWSPCGNYLASASFDATTCIWK 89
Cdd:smart00320   1 SGELLKTL-KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
141-177 3.74e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.41  E-value: 3.74e-05
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 4757988    141 ECVSVLNSHTQDVKHVVWHPSQELLASASYDDTVKLY 177
Cdd:pfam00400   2 KLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
58-88 1.65e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.48  E-value: 1.65e-04
                          10        20        30
                  ....*....|....*....|....*....|.
gi 4757988     58 EGHQRTVRKVAWSPCGNYLASASFDATTCIW 88
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
PTZ00421 PTZ00421
coronin; Provisional
 103-242 1.77e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.96  E-value: 1.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988   103 GHENEVKSVAWAPSGNL-LATCSRDKSVWVWEVDEEDEYECVSV----LNSHTQDVKHVVWHPS-QELLASASYDDTVKL 176
Cdd:PTZ00421  73 GQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIPEEGLTQNISDpivhLQGHTKKVGIVSFHPSaMNVLASAGADMVVNV 152

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4757988   177 YREEEDdwVCCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRqylPGNEQGVACSGSDPSWK 242
Cdd:PTZ00421 153 WDVERG--KAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID---PRDGTIVSSVEAHASAK 213
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 186-337 1.84e-04

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 42.71  E-value: 1.84e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988  186 CCATLEGHESTVWSLAFDPSGQRLASCSDDRTVRIWRqyLPGNEqgvacsgsdpswkCICTLSGfHSRTIYDIAWCqltg 265
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWD--LETGE-------------LLRTLKG-HTGPVRDVAAS---- 60

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4757988  266 alatacgddairvfqedpnsdpqqptfsltahlhqAHSQdvncvawnpkepgLLASCSDDGEVAFWKYQRPE 337
Cdd:cd00200  61 -----------------------------------ADGT-------------YLASGSSDKTIRLWDLETGE 84
PTZ00421 PTZ00421
coronin; Provisional
 37-165 2.71e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 2.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988    37 DRRIRIWG--TEGDSWICKSVLSE--GHQRTVRKVAWSPCG-NYLASASFDATTCIWKKNQDdfECVTTLEGHENEVKSV 111
Cdd:PTZ00421  97 DGTIMGWGipEEGLTQNISDPIVHlqGHTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERG--KAVEVIKCHSDQITSL 174

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 4757988   112 AWAPSGNLLATCSRDKSVWVweVDEEDEYECVSVLNSHTQDVKHVVWHPSQELL 165
Cdd:PTZ00421 175 EWNLDGSLLCTTSKDKKLNI--IDPRDGTIVSSVEAHASAKSQRCLWAKRKDLI 226
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 300-332 6.97e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 36.91  E-value: 6.97e-04
                           10        20        30
                   ....*....|....*....|....*....|...
gi 4757988     300 QAHSQDVNCVAWNPKEPgLLASCSDDGEVAFWK 332
Cdd:smart00320   9 KGHTGPVTSVAFSPDGK-YLASGSDDGTIKLWD 40
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 23-135 9.27e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 39.95  E-value: 9.27e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757988     23 AWNPAGTLLASCGG--DRRIRIWGTEGDSwICKsvLSEGHQRTVRkvaWSPCGNYLASASF---DATTCIWkkNQDDFEC 97
Cdd:pfam08662  66 AWSPNGKEFAVIYGymPAKVSFFDLKGNV-IHS--FGEQPRNTIF---WSPFGRLVLLAGFgnlAGDIEFW--DVVNKKK 137

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 4757988     98 VTTLEgHENEVkSVAWAPSGNLLATCSR------DKSVWVWEVD 135
Cdd:pfam08662 138 IATAE-ASNAT-LCEWSPDGRYFLTATTaprlrvDNGFKIWHYN 179
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 4-43 2.51e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 35.37  E-value: 2.51e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 4757988       4 SLVLLGRVPAHpDSRCWFLAWNPAGTLLASCGGDRRIRIW 43
Cdd:smart00320   1 SGELLKTLKGH-TGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 pfam00400
WD domain, G-beta repeat;
300-331 5.83e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.24  E-value: 5.83e-03
                          10        20        30
                  ....*....|....*....|....*....|..
gi 4757988    300 QAHSQDVNCVAWNPKEPgLLASCSDDGEVAFW 331
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGK-LLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
7-43 7.60e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 33.86  E-value: 7.60e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 4757988      7 LLGRVPAHpDSRCWFLAWNPAGTLLASCGGDRRIRIW 43
Cdd:pfam00400   3 LLKTLEGH-TGSVTSLAFSPDGKLLASGSDDGTVKVW 38
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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