|
Name |
Accession |
Description |
Interval |
E-value |
| SrmB |
COG0513 |
Superfamily II DNA and RNA helicase [Replication, recombination and repair]; |
392-783 |
4.03e-154 |
|
Superfamily II DNA and RNA helicase [Replication, recombination and repair];
Pssm-ID: 440279 [Multi-domain] Cd Length: 420 Bit Score: 456.92 E-value: 4.03e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 392 SWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQG-PY 470
Cdd:COG0513 3 SFADLGLSPPLLKALAELGYTTPTPIQAQAIPLILAGRDVLGQAQTGTGKTAAFLLPLL---------QRLDPSRPRaPQ 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 471 AIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDE 550
Cdd:COG0513 74 ALILAPTRELALQVAEELRKLAKYLGLRVATVYGGVSIGRQIRALKRGVDIVVATPGRLLDLIERGALDLSGVETLVLDE 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 551 ADRMIDMGFEPDVQKILEHMPVSnqkpdtdeaedpekmlanfesgkhkyRQTVMFTATMPPAVERLARSYLRRPAVVYIG 630
Cdd:COG0513 154 ADRMLDMGFIEDIERILKLLPKE--------------------------RQTLLFSATMPPEIRKLAKRYLKNPVRIEVA 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 631 SAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNL 710
Cdd:COG0513 208 PENATAETIEQRYYLVDKRDKLELLRRLLRDEDPERAIVFCNTKRGADRLAEKLQKRGISAAALHGDLSQGQRERALDAF 287
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41327771 711 KAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAI 783
Cdd:COG0513 288 RNGKIRVLVATDVAARGIDIDDVSHVINYDLPEDPEDYVHRIGRTGRAGAEGTAISLVTPDERRLLRAIEKLI 360
|
|
| DEADc_DDX23 |
cd17945 |
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and ... |
402-628 |
7.88e-145 |
|
DEAD-box helicase domain of DEAD box protein 23; DDX23 (also called U5 snRNP 100kD protein and PRP28 homolog) is involved in pre-mRNA splicing and its phosphorylated form (by SRPK2) is required for spliceosomal B complex formation. Diseases associated with DDX23 include distal hereditary motor neuropathy, type II. DDX23 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350703 [Multi-domain] Cd Length: 220 Bit Score: 425.20 E-value: 7.88e-145
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDrIEESDQGPYAIILAPTRELA 481
Cdd:cd17945 1 LLRVIRKLGYKEPTPIQRQAIPIGLQNRDIIGIAETGSGKTAAFLIPLLVYISRLPPLD-EETKDDGPYALILAPTRELA 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 482 QQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEP 561
Cdd:cd17945 80 QQIEEETQKFAKPLGIRVVSIVGGHSIEEQAFSLRNGCEILIATPGRLLDCLERRLLVLNQCTYVVLDEADRMIDMGFEP 159
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41327771 562 DVQKILEHMPVSNQKPDTDEAEdpekmlANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVY 628
Cdd:cd17945 160 QVTKILDAMPVSNKKPDTEEAE------KLAASGKHRYRQTMMFTATMPPAVEKIAKGYLRRPVVVT 220
|
|
| PTZ00110 |
PTZ00110 |
helicase; Provisional |
365-795 |
2.16e-123 |
|
helicase; Provisional
Pssm-ID: 240273 [Multi-domain] Cd Length: 545 Bit Score: 382.20 E-value: 2.16e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 365 MTDRDWRIFREDYSITTKGGK-IPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTA 443
Cdd:PTZ00110 103 LSSKEVDEIRKEKEITIIAGEnVPKPVVSFEYTSFPDYILKSLKNAGFTEPTPIQVQGWPIALSGRDMIGIAETGSGKTL 182
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 444 AFLIPLLVWITTLPkidRIEESDqGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVI 523
Cdd:PTZ00110 183 AFLLPAIVHINAQP---LLRYGD-GPIVLVLAPTRELAEQIREQCNKFGASSKIRNTVAYGGVPKRGQIYALRRGVEILI 258
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 524 ATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKIlehmpVSNQKPDtdeaedpekmlanfesgkhkyRQTV 603
Cdd:PTZ00110 259 ACPGRLIDFLESNVTNLRRVTYLVLDEADRMLDMGFEPQIRKI-----VSQIRPD---------------------RQTL 312
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 604 MFTATMPPAVERLARSYLRR-PAVVYIGSAG-KPHERVEQKVFLMSESEKRKKLLAILEQGFDP--PIIIFVNQKKGCDV 679
Cdd:PTZ00110 313 MWSATWPKEVQSLARDLCKEePVHVNVGSLDlTACHNIKQEVFVVEEHEKRGKLKMLLQRIMRDgdKILIFVETKKGADF 392
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 680 LAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAG 759
Cdd:PTZ00110 393 LTKELRLDGWPALCIHGDKKQEERTWVLNEFKTGKSPIMIATDVASRGLDVKDVKYVINFDFPNQIEDYVHRIGRTGRAG 472
|
410 420 430
....*....|....*....|....*....|....*...
gi 41327771 760 KSGVAITFLTKEDSAVFYELKQAILES--PVsscPPEL 795
Cdd:PTZ00110 473 AKGASYTFLTPDKYRLARDLVKVLREAkqPV---PPEL 507
|
|
| PLN00206 |
PLN00206 |
DEAD-box ATP-dependent RNA helicase; Provisional |
365-814 |
1.63e-93 |
|
DEAD-box ATP-dependent RNA helicase; Provisional
Pssm-ID: 215103 [Multi-domain] Cd Length: 518 Bit Score: 302.86 E-value: 1.63e-93
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 365 MTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAA 444
Cdd:PLN00206 95 LSSSQAELLRRKLEIHVKGEAVPPPILSFSSCGLPPKLLLNLETAGYEFPTPIQMQAIPAALSGRSLLVSADTGSGKTAS 174
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 445 FLIPLLVWITTLpkidRIEES--DQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIV 522
Cdd:PLN00206 175 FLVPIISRCCTI----RSGHPseQRNPLAMVLTPTRELCVQVEDQAKVLGKGLPFKTALVVGGDAMPQQLYRIQQGVELI 250
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 523 IATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPvsnqKPdtdeaedpekmlanfesgkhkyrQT 602
Cdd:PLN00206 251 VGTPGRLIDLLSKHDIELDNVSVLVLDEVDCMLERGFRDQVMQIFQALS----QP-----------------------QV 303
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 603 VMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAIL--EQGFDPPIIIFVNQKKGCDVL 680
Cdd:PLN00206 304 LLFSATVSPEVEKFASSLAKDIILISIGNPNRPNKAVKQLAIWVETKQKKQKLFDILksKQHFKPPAVVFVSSRLGADLL 383
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 681 AKSLEKM-GYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAG 759
Cdd:PLN00206 384 ANAITVVtGLKALSIHGEKSMKERREVMKSFLVGEVPVIVATGVLGRGVDLLRVRQVIIFDMPNTIKEYIHQIGRASRMG 463
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*
gi 41327771 760 KSGVAITFLTKEDSAVFYELKQaILESPVSSCPPELANHPDAQHkpGTILTKKRR 814
Cdd:PLN00206 464 EKGTAIVFVNEEDRNLFPELVA-LLKSSGAAIPRELANSRYLGS--GRKRKKKRR 515
|
|
| PRK11776 |
PRK11776 |
ATP-dependent RNA helicase DbpA; Provisional |
397-805 |
5.22e-91 |
|
ATP-dependent RNA helicase DbpA; Provisional
Pssm-ID: 236977 [Multi-domain] Cd Length: 460 Bit Score: 294.40 E-value: 5.22e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 397 SLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQGPYAIILAP 476
Cdd:PRK11776 10 PLPPALLANLNELGYTEMTPIQAQSLPAILAGKDVIAQAKTGSGKTAAFGLGLL---------QKLDVKRFRVQALVLCP 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 477 TRELAQQIEEETIKFGKPL-GIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMI 555
Cdd:PRK11776 81 TRELADQVAKEIRRLARFIpNIKVLTLCGGVPMGPQIDSLEHGAHIIVGTPGRILDHLRKGTLDLDALNTLVLDEADRML 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 556 DMGFEPDVQKILEHMPvsnqkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAgkp 635
Cdd:PRK11776 161 DMGFQDAIDAIIRQAP--------------------------ARRQTLLFSATYPEGIAAISQRFQRDPVEVKVEST--- 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 636 HE--RVEQKVFLMSESEKRKKLLAILEQgFDP-PIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKA 712
Cdd:PRK11776 212 HDlpAIEQRFYEVSPDERLPALQRLLLH-HQPeSCVVFCNTKKECQEVADALNAQGFSALALHGDLEQRDRDQVLVRFAN 290
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 713 GAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSAVFYELKQAiLESPVSSCP 792
Cdd:PRK11776 291 RSCSVLVATDVAARGLDIKALEAVINYELARDPEVHVHRIGRTGRAGSKGLALSLVAPEEMQRANAIEDY-LGRKLNWEP 369
|
410
....*....|....
gi 41327771 793 -PELANHPDAQHKP 805
Cdd:PRK11776 370 lPSLSPLSGVPLLP 383
|
|
| DEADc |
cd00268 |
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family ... |
402-627 |
5.24e-91 |
|
DEAD-box helicase domain of DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350669 [Multi-domain] Cd Length: 196 Bit Score: 284.33 E-value: 5.24e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKidrieESDQGPYAIILAPTRELA 481
Cdd:cd00268 1 LLKALKKLGFEKPTPIQAQAIPLILSGRDVIGQAQTGSGKTLAFLLPILEKLLPEPK-----KKGRGPQALVLAPTRELA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 482 QQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEP 561
Cdd:cd00268 76 MQIAEVARKLGKGTGLKVAAIYGGAPIKKQIEALKKGPDIVVGTPGRLLDLIERGKLDLSNVKYLVLDEADRMLDMGFEE 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41327771 562 DVQKILEHMPvsnqkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAVERLARSYLRRPAVV 627
Cdd:cd00268 156 DVEKILSALP--------------------------KDRQTLLFSATLPEEVKELAKKFLKNPVRI 195
|
|
| DEADc_DDX3_DDX4 |
cd17967 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes ... |
392-629 |
3.20e-82 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX3 and DDX4; This subfamily includes Drosophila melanogaster Vasa, which is essential for development. DEAD box protein 3 (DDX3) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DDX3 and DDX4 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350725 [Multi-domain] Cd Length: 221 Bit Score: 262.42 E-value: 3.20e-82
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 392 SWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLL-VWITTLPKIDRIEESDQGPY 470
Cdd:cd17967 1 SFEEAGLRELLLENIKRAGYTKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPIIsKLLEDGPPSVGRGRRKAYPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 471 AIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDE 550
Cdd:cd17967 81 ALILAPTRELAIQIYEEARKFSYRSGVRSVVVYGGADVVHQQLQLLRGCDILVATPGRLVDFIERGRISLSSIKFLVLDE 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41327771 551 ADRMIDMGFEPDVQKILEHMPVsnqkPDTDEaedpekmlanfesgkhkyRQTVMFTATMPPAVERLARSYLRRpavvYI 629
Cdd:cd17967 161 ADRMLDMGFEPQIRKIVEHPDM----PPKGE------------------RQTLMFSATFPREIQRLAADFLKN----YI 213
|
|
| PRK10590 |
PRK10590 |
ATP-dependent RNA helicase RhlE; Provisional |
392-766 |
1.13e-80 |
|
ATP-dependent RNA helicase RhlE; Provisional
Pssm-ID: 236722 [Multi-domain] Cd Length: 456 Bit Score: 266.67 E-value: 1.13e-80
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 392 SWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPkidrIEESDQGPY- 470
Cdd:PRK10590 2 SFDSLGLSPDILRAVAEQGYREPTPIQQQAIPAVLEGRDLMASAQTGTGKTAGFTLPLLQHLITRQ----PHAKGRRPVr 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 471 AIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDE 550
Cdd:PRK10590 78 ALILTPTRELAAQIGENVRDYSKYLNIRSLVVFGGVSINPQMMKLRGGVDVLVATPGRLLDLEHQNAVKLDQVEILVLDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 551 ADRMIDMGFEPDVQKILEHMPVSnqkpdtdeaedpekmlanfesgkhkyRQTVMFTATMPPAVERLARSYLRRPAVVYIG 630
Cdd:PRK10590 158 ADRMLDMGFIHDIRRVLAKLPAK--------------------------RQNLLFSATFSDDIKALAEKLLHNPLEIEVA 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 631 SAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNL 710
Cdd:PRK10590 212 RRNTASEQVTQHVHFVDKKRKRELLSQMIGKGNWQQVLVFTRTKHGANHLAEQLNKDGIRSAAIHGNKSQGARTRALADF 291
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*.
gi 41327771 711 KAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAIT 766
Cdd:PRK10590 292 KSGDIRVLVATDIAARGLDIEELPHVVNYELPNVPEDYVHRIGRTGRAAATGEALS 347
|
|
| DEADc_DDX46 |
cd17953 |
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) ... |
380-624 |
1.02e-79 |
|
DEAD-box helicase domain of DEAD box protein 46; DDX46 (also called Prp5-like DEAD-box protein) is a component of the 17S U2 snRNP complex. It plays an important role in pre-mRNA splicing and has a role in antiviral innate immunity. DDX46 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350711 [Multi-domain] Cd Length: 222 Bit Score: 255.76 E-value: 1.02e-79
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 380 TTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKI 459
Cdd:cd17953 1 KVRGKDCPKPIQKWSQCGLSEKVLDLIKKLGYEKPTPIQAQALPAIMSGRDVIGIAKTGSGKTLAFLLPMFRHIKDQRPV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 460 drieESDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVL---ENR 536
Cdd:cd17953 81 ----KPGEGPIGLIMAPTRELALQIYVECKKFSKALGLRVVCVYGGSGISEQIAELKRGAEIVVCTPGRMIDILtanNGR 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 537 YLVLSRCTYVVLDEADRMIDMGFEPDVQKIlehmpVSNQKPDtdeaedpekmlanfesgkhkyRQTVMFTATMPPAVERL 616
Cdd:cd17953 157 VTNLRRVTYVVLDEADRMFDMGFEPQIMKI-----VNNIRPD---------------------RQTVLFSATFPRKVEAL 210
|
....*...
gi 41327771 617 ARSYLRRP 624
Cdd:cd17953 211 ARKVLHKP 218
|
|
| PRK11634 |
PRK11634 |
ATP-dependent RNA helicase DeaD; Provisional |
392-768 |
7.02e-78 |
|
ATP-dependent RNA helicase DeaD; Provisional
Pssm-ID: 236941 [Multi-domain] Cd Length: 629 Bit Score: 264.40 E-value: 7.02e-78
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 392 SWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQGPYA 471
Cdd:PRK11634 7 TFADLGLKAPILEALNDLGYEKPSPIQAECIPHLLNGRDVLGMAQTGSGKTAAFSLPLL---------HNLDPELKAPQI 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 472 IILAPTRELAQQIEEETIKFGKPL-GIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDE 550
Cdd:PRK11634 78 LVLAPTRELAVQVAEAMTDFSKHMrGVNVVALYGGQRYDVQLRALRQGPQIVVGTPGRLLDHLKRGTLDLSKLSGLVLDE 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 551 ADRMIDMGFEPDVQKILEHMPVSNQkpdtdeaedpekmlanfesgkhkyrqTVMFTATMPPAVERLARSYLRRPAVVYIG 630
Cdd:PRK11634 158 ADEMLRMGFIEDVETIMAQIPEGHQ--------------------------TALFSATMPEAIRRITRRFMKEPQEVRIQ 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 631 SAGKPHERVEQKVFLMSESEKRKKLLAILE-QGFDPPIIiFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSN 709
Cdd:PRK11634 212 SSVTTRPDISQSYWTVWGMRKNEALVRFLEaEDFDAAII-FVRTKNATLEVAEALERNGYNSAALNGDMNQALREQTLER 290
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 41327771 710 LKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFL 768
Cdd:PRK11634 291 LKDGRLDILIATDVAARGLDVERISLVVNYDIPMDSESYVHRIGRTGRAGRAGRALLFV 349
|
|
| PRK04537 |
PRK04537 |
ATP-dependent RNA helicase RhlB; Provisional |
398-767 |
4.12e-77 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235307 [Multi-domain] Cd Length: 572 Bit Score: 260.65 E-value: 4.12e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 398 LPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKI-DRIEESdqgPYAIILAP 476
Cdd:PRK04537 16 LHPALLAGLESAGFTRCTPIQALTLPVALPGGDVAGQAQTGTGKTLAFLVAVMNRLLSRPALaDRKPED---PRALILAP 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 477 TRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLV-LSRCTYVVLDEADRMI 555
Cdd:PRK04537 93 TRELAIQIHKDAVKFGADLGLRFALVYGGVDYDKQRELLQQGVDVIIATPGRLIDYVKQHKVVsLHACEICVLDEADRMF 172
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 556 DMGFEPDVQKILEHMPvsnqkpdtdeaedpekmlanfESGKhkyRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKP 635
Cdd:PRK04537 173 DLGFIKDIRFLLRRMP---------------------ERGT---RQTLLFSATLSHRVLELAYEHMNEPEKLVVETETIT 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 636 HERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAK 715
Cdd:PRK04537 229 AARVRQRIYFPADEEKQTLLLGLLSRSEGARTMVFVNTKAFVERVARTLERHGYRVGVLSGDVPQKKRESLLNRFQKGQL 308
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|..
gi 41327771 716 DILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITF 767
Cdd:PRK04537 309 EILVATDVAARGLHIDGVKYVYNYDLPFDAEDYVHRIGRTARLGEEGDAISF 360
|
|
| PRK01297 |
PRK01297 |
ATP-dependent RNA helicase RhlB; Provisional |
370-799 |
4.93e-77 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 234938 [Multi-domain] Cd Length: 475 Bit Score: 257.53 E-value: 4.93e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 370 WRIfrEDYSITTKGGKipnpiRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPL 449
Cdd:PRK01297 73 WKL--EDFVVEPQEGK-----TRFHDFNLAPELMHAIHDLGFPYCTPIQAQVLGYTLAGHDAIGRAQTGTGKTAAFLISI 145
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 450 lvwITTLPKIDRIEESDQG-PYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMG-CEIVIATPG 527
Cdd:PRK01297 146 ---INQLLQTPPPKERYMGePRALIIAPTRELVVQIAKDAAALTKYTGLNVMTFVGGMDFDKQLKQLEARfCDILVATPG 222
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 528 RLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQkpdtdeaedpekmlanfesgkhkyRQTVMFTA 607
Cdd:PRK01297 223 RLLDFNQRGEVHLDMVEVMVLDEADRMLDMGFIPQVRQIIRQTPRKEE------------------------RQTLLFSA 278
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 608 TMPPAVERLARSYLRRPAVVYIGSAGKPHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKM 687
Cdd:PRK01297 279 TFTDDVMNLAKQWTTDPAIVEIEPENVASDTVEQHVYAVAGSDKYKLLYNLVTQNPWERVMVFANRKDEVRRIEERLVKD 358
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 688 GYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITF 767
Cdd:PRK01297 359 GINAAQLSGDVPQHKRIKTLEGFREGKIRVLVATDVAGRGIHIDGISHVINFTLPEDPDDYVHRIGRTGRAGASGVSISF 438
|
410 420 430
....*....|....*....|....*....|..
gi 41327771 768 LTKEDSAVFYELKQAILESPVSSCPPELANHP 799
Cdd:PRK01297 439 AGEDDAFQLPEIEELLGRKISCEMPPAELLKP 470
|
|
| PRK04837 |
PRK04837 |
ATP-dependent RNA helicase RhlB; Provisional |
395-767 |
6.74e-77 |
|
ATP-dependent RNA helicase RhlB; Provisional
Pssm-ID: 235314 [Multi-domain] Cd Length: 423 Bit Score: 255.67 E-value: 6.74e-77
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 395 DSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESdqGPYAIIL 474
Cdd:PRK04837 12 DFALHPQVVEALEKKGFHNCTPIQALALPLTLAGRDVAGQAQTGTGKTMAFLTATFHYLLSHPAPEDRKVN--QPRALIM 89
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 475 APTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRM 554
Cdd:PRK04837 90 APTRELAVQIHADAEPLAQATGLKLGLAYGGDGYDKQLKVLESGVDILIGTTGRLIDYAKQNHINLGAIQVVVLDEADRM 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 555 IDMGFEPDVQKILEHMPVSNQkpdtdeaedpekmlanfesgkhkyRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGK 634
Cdd:PRK04837 170 FDLGFIKDIRWLFRRMPPANQ------------------------RLNMLFSATLSYRVRELAFEHMNNPEYVEVEPEQK 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 635 PHERVEQKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGA 714
Cdd:PRK04837 226 TGHRIKEELFYPSNEEKMRLLQTLIEEEWPDRAIIFANTKHRCEEIWGHLAADGHRVGLLTGDVAQKKRLRILEEFTRGD 305
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|...
gi 41327771 715 KDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITF 767
Cdd:PRK04837 306 LDILVATDVAARGLHIPAVTHVFNYDLPDDCEDYVHRIGRTGRAGASGHSISL 358
|
|
| DEADc_DDX5_DDX17 |
cd17966 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are ... |
402-627 |
6.55e-75 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX5 and DDX17; DDX5 and DDX17 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350724 [Multi-domain] Cd Length: 197 Bit Score: 241.89 E-value: 6.55e-75
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIdrieESDQGPYAIILAPTRELA 481
Cdd:cd17966 1 VMDELKRQGFTEPTAIQAQGWPMALSGRDMVGIAQTGSGKTLAFLLPAIVHINAQPPL----ERGDGPIVLVLAPTRELA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 482 QQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEP 561
Cdd:cd17966 77 QQIQQEANKFGGSSRLRNTCVYGGAPKGPQIRDLRRGVEICIATPGRLIDFLDQGKTNLRRVTYLVLDEADRMLDMGFEP 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41327771 562 DVQKIlehmpVSNQKPDtdeaedpekmlanfesgkhkyRQTVMFTATMPPAVERLARSYLRRPAVV 627
Cdd:cd17966 157 QIRKI-----VDQIRPD---------------------RQTLMWSATWPKEVRRLAEDFLKDYIQV 196
|
|
| PRK11192 |
PRK11192 |
ATP-dependent RNA helicase SrmB; Provisional |
393-767 |
1.27e-71 |
|
ATP-dependent RNA helicase SrmB; Provisional
Pssm-ID: 236877 [Multi-domain] Cd Length: 434 Bit Score: 241.77 E-value: 1.27e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 393 WKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKidrieeSDQGPYAI 472
Cdd:PRK11192 3 FSELELDESLLEALQDKGYTRPTAIQAEAIPPALDGRDVLGSAPTGTGKTAAFLLPALQHLLDFPR------RKSGPPRI 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 473 -ILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEA 551
Cdd:PRK11192 77 lILTPTRELAMQVADQARELAKHTHLDIATITGGVAYMNHAEVFSENQDIVVATPGRLLQYIKEENFDCRAVETLILDEA 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 552 DRMIDMGFEPDVQKIlehmpvsnqkpdtdeaedpekmlanfeSGKHKYR-QTVMFTATMP-PAVERLARSYLRRPAVVYI 629
Cdd:PRK11192 157 DRMLDMGFAQDIETI---------------------------AAETRWRkQTLLFSATLEgDAVQDFAERLLNDPVEVEA 209
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 630 GSAGKPHERVEQKVFLMSESEKRKKLLA-ILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALS 708
Cdd:PRK11192 210 EPSRRERKKIHQWYYRADDLEHKTALLChLLKQPEVTRSIVFVRTRERVHELAGWLRKAGINCCYLEGEMVQAKRNEAIK 289
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*....
gi 41327771 709 NLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITF 767
Cdd:PRK11192 290 RLTDGRVNVLVATDVAARGIDIDDVSHVINFDMPRSADTYLHRIGRTGRAGRKGTAISL 348
|
|
| DEADc_DDX42 |
cd17952 |
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor ... |
402-627 |
2.14e-71 |
|
DEAD-box helicase domain of DEAD box protein 42; DDX42 (also called Splicing Factor 3B-Associated 125 kDa Protein, RHELP, or RNAHP) is an NTPase with a preference for ATP, the hydrolysis of which is enhanced by various RNA substrates. It acts as a non-processive RNA helicase with protein displacement and RNA annealing activities. DDX42 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350710 [Multi-domain] Cd Length: 197 Bit Score: 232.69 E-value: 2.14e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIdrieESDQGPYAIILAPTRELA 481
Cdd:cd17952 1 LLNAIRKQEYEQPTPIQAQALPVALSGRDMIGIAKTGSGKTAAFIWPMLVHIMDQREL----EKGEGPIAVIVAPTRELA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 482 QQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEP 561
Cdd:cd17952 77 QQIYLEAKKFGKAYNLRVVAVYGGGSKWEQAKALQEGAEIVVATPGRLIDMVKKKATNLQRVTYLVLDEADRMFDMGFEY 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41327771 562 DVQKILEHMpvsnqKPDtdeaedpekmlanfesgkhkyRQTVMFTATMPPAVERLARSYLRRPAVV 627
Cdd:cd17952 157 QVRSIVGHV-----RPD---------------------RQTLLFSATFKKKIEQLARDILSDPIRV 196
|
|
| DEADc_DDX4 |
cd18052 |
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA ... |
383-622 |
4.32e-71 |
|
DEAD-box helicase domain of DEAD box protein 4; DEAD box protein 4 (DDX4, also known as VASA homolog) is an ATP-dependent RNA helicase required during spermatogenesis and is essential for the germline integrity. DEAD-box helicases are a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350810 [Multi-domain] Cd Length: 264 Bit Score: 234.48 E-value: 4.32e-71
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 383 GGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwiTTLPKiDRI 462
Cdd:cd18052 35 GRNPPPAILTFEEANLCETLLKNIRKAGYEKPTPVQKYAIPIILAGRDLMACAQTGSGKTAAFLLPVL---TGMMK-EGL 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 463 EESD----QGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYL 538
Cdd:cd18052 111 TASSfsevQEPQALIVAPTRELANQIFLEARKFSYGTCIRPVVVYGGVSVGHQIRQIEKGCHILVATPGRLLDFIGRGKI 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 539 VLSRCTYVVLDEADRMIDMGFEPDVQKILEH--MPVSNQkpdtdeaedpekmlanfesgkhkyRQTVMFTATMPPAVERL 616
Cdd:cd18052 191 SLSKLKYLILDEADRMLDMGFGPEIRKLVSEpgMPSKED------------------------RQTLMFSATFPEEIQRL 246
|
....*.
gi 41327771 617 ARSYLR 622
Cdd:cd18052 247 AAEFLK 252
|
|
| DEADc_DDX47 |
cd17954 |
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can ... |
392-624 |
4.93e-67 |
|
DEAD-box helicase domain of DEAD box protein 47; DDX47 (also called E4-DEAD box protein) can shuttle between the nucleus and the cytoplasm, and has an RNA-independent ATPase activity. DX47 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350712 [Multi-domain] Cd Length: 203 Bit Score: 221.04 E-value: 4.93e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 392 SWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPkidrieesdQGPYA 471
Cdd:cd17954 1 TFKELGVCEELCEACEKLGWKKPTKIQEEAIPVALQGRDIIGLAETGSGKTAAFALPILQALLENP---------QRFFA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 472 IILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLEN-RYLVLSRCTYVVLDE 550
Cdd:cd17954 72 LVLAPTRELAQQISEQFEALGSSIGLKSAVLVGGMDMMAQAIALAKKPHVIVATPGRLVDHLENtKGFSLKSLKFLVMDE 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41327771 551 ADRMIDMGFEPDVQKILEHMPvsnqkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAVERLARSYLRRP 624
Cdd:cd17954 152 ADRLLNMDFEPEIDKILKVIP--------------------------RERTTYLFSATMTTKVAKLQRASLKNP 199
|
|
| PTZ00424 |
PTZ00424 |
helicase 45; Provisional |
390-772 |
1.10e-63 |
|
helicase 45; Provisional
Pssm-ID: 185609 [Multi-domain] Cd Length: 401 Bit Score: 218.93 E-value: 1.10e-63
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 390 IRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIpllvwiTTLPKIDRIEESDQgp 469
Cdd:PTZ00424 27 VDSFDALKLNEDLLRGIYSYGFEKPSAIQQRGIKPILDGYDTIGQAQSGTGKTATFVI------AALQLIDYDLNACQ-- 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 470 yAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLD 549
Cdd:PTZ00424 99 -ALILAPTRELAQQIQKVVLALGDYLKVRCHACVGGTVVRDDINKLKAGVHMVVGTPGRVYDMIDKRHLRVDDLKLFILD 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 550 EADRMIDMGFEPDVQKILEHMPvsnqkPDTdeaedpekmlanfesgkhkyrQTVMFTATMPPAVERLARSYLRRPAVVYI 629
Cdd:PTZ00424 178 EADEMLSRGFKGQIYDVFKKLP-----PDV---------------------QVALFSATMPNEILELTTKFMRDPKRILV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 630 GSAGKPHERVEQ-KVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALS 708
Cdd:PTZ00424 232 KKDELTLEGIRQfYVAVEKEEWKFDTLCDLYETLTITQAIIYCNTRRKVDYLTKKMHERDFTVSCMHGDMDQKDRDLIMR 311
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41327771 709 NLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKED 772
Cdd:PTZ00424 312 EFRSGSTRVLITTDLLARGIDVQQVSLVINYDLPASPENYIHRIGRSGRFGRKGVAINFVTPDD 375
|
|
| DEADc_DDX5 |
cd18049 |
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, ... |
373-631 |
1.95e-62 |
|
DEAD-box helicase domain of DEAD box protein 5; DDX5 (also called RNA helicase P68, HLR1, G17P1, or HUMP68) is involved in pathways that include the alteration of RNA structures, plays a role as a coregulator of transcription, a regulator of splicing, and in the processing of small noncoding RNAs. It synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. Dysregulation of this gene may play a role in cancer development. DDX5 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350807 [Multi-domain] Cd Length: 234 Bit Score: 209.87 E-value: 1.95e-62
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 373 FREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVW 452
Cdd:cd18049 6 YRRSKEITVRGHNCPKPVLNFYEANFPANVMDVIARQNFTEPTAIQAQGWPVALSGLDMVGVAQTGSGKTLSYLLPAIVH 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 453 ITTLPKIDRieesDQGPYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDV 532
Cdd:cd18049 86 INHQPFLER----GDGPICLVLAPTRELAQQVQQVAAEYGRACRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDF 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 533 LENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMpvsnqKPDtdeaedpekmlanfesgkhkyRQTVMFTATMPPA 612
Cdd:cd18049 162 LEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQI-----RPD---------------------RQTLMWSATWPKE 215
|
250
....*....|....*....
gi 41327771 613 VERLARSYLRRPAVVYIGS 631
Cdd:cd18049 216 VRQLAEDFLKDYIHINIGA 234
|
|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
415-616 |
4.94e-61 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 203.63 E-value: 4.94e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 415 TPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKP 494
Cdd:pfam00270 1 TPIQAEAIPAILEGRDVLVQAPTGSGKTLAFLLPAL---------EALDKLDNGPQALVLAPTRELAEQIYEELKKLGKG 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 495 LGIRTVAVIGGISREDQGFRLRmGCEIVIATPGRLIDVLENRYLvLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPvsn 574
Cdd:pfam00270 72 LGLKVASLLGGDSRKEQLEKLK-GPDILVGTPGRLLDLLQERKL-LKNLKLLVLDEAHRLLDMGFGPDLEEILRRLP--- 146
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 41327771 575 qkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAVERL 616
Cdd:pfam00270 147 -----------------------KKRQILLLSATLPRNLEDL 165
|
|
| DEADc_DDX54 |
cd17959 |
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner ... |
398-627 |
4.23e-60 |
|
DEAD-box helicase domain of DEAD box protein 54; DDX54 interacts in a hormone-dependent manner with nuclear receptors, and represses their transcriptional activity. DDX54 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350717 [Multi-domain] Cd Length: 205 Bit Score: 202.53 E-value: 4.23e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 398 LPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLlvwittlpkIDRIEESDQ--GPYAIILA 475
Cdd:cd17959 8 LSPPLLRAIKKKGYKVPTPIQRKTIPLILDGRDVVAMARTGSGKTAAFLIPM---------IEKLKAHSPtvGARALILS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 476 PTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQgFRLRMGC-EIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRM 554
Cdd:cd17959 79 PTRELALQTLKVTKELGKFTDLRTALLVGGDSLEEQ-FEALASNpDIIIATPGRLLHLLVEMNLKLSSVEYVVFDEADRL 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41327771 555 IDMGFEPDVQKILEHMPVSnqkpdtdeaedpekmlanfesgkhkyRQTVMFTATMPPAVERLARSYLRRPAVV 627
Cdd:cd17959 158 FEMGFAEQLHEILSRLPEN--------------------------RQTLLFSATLPKLLVEFAKAGLNEPVLI 204
|
|
| DEADc_DDX17 |
cd18050 |
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or ... |
342-630 |
8.22e-60 |
|
DEAD-box helicase domain of DEAD box protein 17; DDX17 (also called DEAD Box Protein P72 or DEAD Box Protein P82) has a wide variety of functions including regulating the alternative splicing of exons exhibiting specific features such as the inclusion of AC-rich alternative exons in CD44 transcripts, playing a role in innate immunity, and promoting mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1 in an ATPase-dependent manner. DDX17 synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and is involved in skeletal muscle differentiation. DDX17 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350808 [Multi-domain] Cd Length: 271 Bit Score: 204.09 E-value: 8.22e-60
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 342 KLRKKeakqRWD---------DRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYK 412
Cdd:cd18050 8 RLRKK----KWDlselpkfekNFYVEHPEVARMTQYDVEELRRKKEITIRGVGCPKPVFAFHQANFPQYVMDVLLDQNFK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 413 EPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRieesDQGPYAIILAPTRELAQQIEEETIKFG 492
Cdd:cd18050 84 EPTPIQCQGFPLALSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPYLER----GDGPICLVLAPTRELAQQVQQVADDYG 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 493 KPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMpv 572
Cdd:cd18050 160 KSSRLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLEAGKTNLRRCTYLVLDEADRMLDMGFEPQIRKIVDQI-- 237
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....*...
gi 41327771 573 snqKPDtdeaedpekmlanfesgkhkyRQTVMFTATMPPAVERLARSYLRRPAVVYIG 630
Cdd:cd18050 238 ---RPD---------------------RQTLMWSATWPKEVRQLAEDFLRDYVQINIG 271
|
|
| DEADc_DDX43_DDX53 |
cd17958 |
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis ... |
402-628 |
2.11e-59 |
|
DEAD-box helicase domain of DEAD box proteins 43 and 53; DDX43 (also called cancer/testis antigen 13 or helical antigen) displays tumor-specific expression. Diseases associated with DDX43 include rheumatoid lung disease. DDX53 is also called cancer/testis antigen 26 or DEAD-Box Protein CAGE. Both DDX46 and DDX53 are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350716 [Multi-domain] Cd Length: 197 Bit Score: 200.38 E-value: 2.11e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWI--TTLPKIDRIeesdqGPYAIILAPTRE 479
Cdd:cd17958 1 IMKEIKKQGFEKPSPIQSQAWPIILQGIDLIGVAQTGTGKTLAYLLPGFIHLdlQPIPREQRN-----GPGVLVLTPTRE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 480 LAQQIEEETIKFgKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGF 559
Cdd:cd17958 76 LALQIEAECSKY-SYKGLKSVCVYGGGNRNEQIEDLSKGVDIIIATPGRLNDLQMNNVINLKSITYLVLDEADRMLDMGF 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41327771 560 EPDVQKILEHMpvsnqKPDtdeaedpekmlanfesgkhkyRQTVMFTATMPPAVERLARSYLRRPAVVY 628
Cdd:cd17958 155 EPQIRKILLDI-----RPD---------------------RQTIMTSATWPDGVRRLAQSYLKDPMIVY 197
|
|
| DEADc_DDX3 |
cd18051 |
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD ... |
375-621 |
2.58e-58 |
|
DEAD-box helicase domain of DEAD box protein 3; DDX3 (also called helicase-like protein, DEAD box, X isoform, or DDX14) has been reported to display a high level of RNA-independent ATPase activity stimulated by both RNA and DNA. This protein has multiple conserved domains and is thought to play roles in both the nucleus and cytoplasm. Nuclear roles include transcriptional regulation, mRNP assembly, pre-mRNA splicing, and mRNA export. In the cytoplasm, this protein is thought to be involved in translation, cellular signaling, and viral replication. Misregulation of this gene has been implicated in tumorigenesis. Diseases associated with DDX3 include mental retardation, X-linked 102 and agenesis of the corpus callosum, with facial anomalies and robin sequence. DDX3 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350809 [Multi-domain] Cd Length: 249 Bit Score: 199.11 E-value: 2.58e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 375 EDYSITTKGGKIPNPIRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWIT 454
Cdd:cd18051 5 EDIPVEATGENCPPHIETFSDLDLGEIIRNNIELARYTKPTPVQKHAIPIIKSKRDLMACAQTGSGKTAAFLLPILSQIY 84
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 455 TL-PKIDRIEESDQG------PYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPG 527
Cdd:cd18051 85 EQgPGESLPSESGYYgrrkqyPLALVLAPTRELASQIYDEARKFAYRSRVRPCVVYGGADIGQQMRDLERGCHLLVATPG 164
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 528 RLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEH--MPVSNQkpdtdeaedpekmlanfesgkhkyRQTVMF 605
Cdd:cd18051 165 RLVDMLERGKIGLDYCKYLVLDEADRMLDMGFEPQIRRIVEQdtMPPTGE------------------------RQTLMF 220
|
250
....*....|....*.
gi 41327771 606 TATMPPAVERLARSYL 621
Cdd:cd18051 221 SATFPKEIQMLARDFL 236
|
|
| DEADc_DDX49 |
cd17955 |
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the ... |
398-624 |
3.84e-58 |
|
DEAD-box helicase domain of DEAD box protein 49; DDX49 (also called Dbp8) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350713 [Multi-domain] Cd Length: 204 Bit Score: 197.06 E-value: 3.84e-58
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 398 LPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQGPYAIILAPT 477
Cdd:cd17955 6 LSSWLVKQCASLGIKEPTPIQKLCIPEILAGRDVIGGAKTGSGKTAAFALPIL---------QRLSEDPYGIFALVLTPT 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 478 RELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYL---VLSRCTYVVLDEADRM 554
Cdd:cd17955 77 RELAYQIAEQFRALGAPLGLRCCVIVGGMDMVKQALELSKRPHIVVATPGRLADHLRSSDDttkVLSRVKFLVLDEADRL 156
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 555 IDMGFEPDVQKILEHMPvsnqkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAVERLARSYLRRP 624
Cdd:cd17955 157 LTGSFEDDLATILSALP--------------------------PKRQTLLFSATLTDALKALKELFGNKP 200
|
|
| DEADc_DDX31 |
cd17949 |
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) ... |
410-630 |
1.68e-57 |
|
DEAD-box helicase domain of DEAD box protein 31; DDX31 (also called helicain or G2 helicase) plays a role in ribosome biogenesis and TP53/p53 regulation through its interaction with NPM1. DDX31 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350707 [Multi-domain] Cd Length: 214 Bit Score: 195.50 E-value: 1.68e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 410 GYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTL-PKIDRieesDQGPYAIILAPTRELAQQIEEET 488
Cdd:cd17949 10 GIEKPTAIQKLAIPVLLQGRDVLVRSQTGSGKTLAYLLPIIQRLLSLePRVDR----SDGTLALVLVPTRELALQIYEVL 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 489 IKFGKP-LGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLEN-RYLVLSRCTYVVLDEADRMIDMGFEPDVQKI 566
Cdd:cd17949 86 EKLLKPfHWIVPGYLIGGEKRKSEKARLRKGVNILIATPGRLLDHLKNtQSFDVSNLRWLVLDEADRLLDMGFEKDITKI 165
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41327771 567 LEHMpvsnqkpdtdeaeDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPavVYIG 630
Cdd:cd17949 166 LELL-------------DDKRSKAGGEKSKPSRRQTVLVSATLTDGVKRLAGLSLKDP--VYID 214
|
|
| DEADc_DDX52 |
cd17957 |
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ... |
402-630 |
3.62e-57 |
|
DEAD-box helicase domain of DEAD box protein 52; DDX52 (also called ROK1 and HUSSY19) is ubiquitously expressed in testis, endometrium, and other tissues in humans. DDX52 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350715 [Multi-domain] Cd Length: 198 Bit Score: 193.96 E-value: 3.62e-57
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLlvwittlpkIDRIEESDQ--GPYAIILAPTRE 479
Cdd:cd17957 1 LLNNLEESGYREPTPIQMQAIPILLHGRDLLACAPTGSGKTLAFLIPI---------LQKLGKPRKkkGLRALILAPTRE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 480 LAQQIEEETIKFGKPLGIRTVAVIGGIS-REDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMG 558
Cdd:cd17957 72 LASQIYRELLKLSKGTGLRIVLLSKSLEaKAKDGPKSITKYDILVSTPLRLVFLLKQGPIDLSSVEYLVLDEADKLFEPG 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41327771 559 FEpdvqkilehmpvsnqkpdtdeaedpEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIG 630
Cdd:cd17957 152 FR-------------------------EQTDEILAACTNPNLQRSLFSATIPSEVEELARSVMKDPIRIIVG 198
|
|
| SF2_C_DEAD |
cd18787 |
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse ... |
639-768 |
2.03e-56 |
|
C-terminal helicase domain of the DEAD box helicases; DEAD-box helicases comprise a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis, and RNA degradation. They are superfamily (SF)2 helicases that, similar to SF1, do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350174 [Multi-domain] Cd Length: 131 Bit Score: 189.64 E-value: 2.03e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 639 VEQKVFLMSESEKRKKLLA-ILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDI 717
Cdd:cd18787 1 IKQLYVVVEEEEKKLLLLLlLLEKLKPGKAIIFVNTKKRVDRLAELLEELGIKVAALHGDLSQEERERALKKFRSGKVRV 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|.
gi 41327771 718 LVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFL 768
Cdd:cd18787 81 LVATDVAARGLDIPGVDHVINYDLPRDAEDYVHRIGRTGRAGRKGTAITFV 131
|
|
| DEADc_DDX41 |
cd17951 |
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts ... |
402-627 |
4.99e-56 |
|
DEAD-box helicase domain of DEAD box protein 41; DDX41 (also called ABS and MPLPF) interacts with several spliceosomal proteins and may recognize the bacterial second messengers cyclic di-GMP and cyclic di-AMP, resulting in the induction of genes involved in the innate immune response. Diseases associated with DDX41 include "myeloproliferative/lymphoproliferative neoplasms, familial" and "Ddx41-related susceptibility to familial myeloproliferative/lymphoproliferative neoplasms". DDX41 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350709 [Multi-domain] Cd Length: 206 Bit Score: 191.40 E-value: 4.99e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWI----TTLPKIDRieesdQGPYAIILAPT 477
Cdd:cd17951 1 ILKGLKKKGIKKPTPIQMQGLPTILSGRDMIGIAFTGSGKTLVFTLPLIMFAleqeKKLPFIKG-----EGPYGLIVCPS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 478 RELAQQIEEETIKFGKPL------GIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEA 551
Cdd:cd17951 76 RELARQTHEVIEYYCKALqeggypQLRCLLCIGGMSVKEQLEVIRKGVHIVVATPGRLMDMLNKKKINLDICRYLCLDEA 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41327771 552 DRMIDMGFEPDVQKILEHMpvsnqkpdtdeaedpekmlanfesgKHKyRQTVMFTATMPPAVERLARSYLRRPAVV 627
Cdd:cd17951 156 DRMIDMGFEEDIRTIFSYF-------------------------KGQ-RQTLLFSATMPKKIQNFAKSALVKPVTV 205
|
|
| DEADc_DDX27 |
cd17947 |
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ... |
402-624 |
1.52e-55 |
|
DEAD-box helicase domain of DEAD box protein 27; DDX27 (also called RHLP, deficiency of ribosomal subunits protein 1 homolog, and probable ATP-dependent RNA helicase DDX27) is involved in the processing of 5.8S and 28S ribosomal RNAs. More specifically, the encoded protein localizes to the nucleolus, where it interacts with the PeBoW complex to ensure proper 3' end formation of 47S rRNA. DDX27 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350705 [Multi-domain] Cd Length: 196 Bit Score: 189.77 E-value: 1.52e-55
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKidrieesdQGPY--AIILAPTRE 479
Cdd:cd17947 1 LLRALSSLGFTKPTPIQAAAIPLALLGKDICASAVTGSGKTAAFLLPILERLLYRPK--------KKAAtrVLVLVPTRE 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 480 LAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLV-LSRCTYVVLDEADRMIDMG 558
Cdd:cd17947 73 LAMQCFSVLQQLAQFTDITFALAVGGLSLKAQEAALRARPDIVIATPGRLIDHLRNSPSFdLDSIEILVLDEADRMLEEG 152
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41327771 559 FEPDVQKILEHMPvsnqkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAVERLARSYLRRP 624
Cdd:cd17947 153 FADELKEILRLCP--------------------------RTRQTMLFSATMTDEVKDLAKLSLNKP 192
|
|
| DEADc_MSS116 |
cd17964 |
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for ... |
398-622 |
3.31e-53 |
|
DEAD-box helicase domain of DEAD-box helicase Mss116; Mss116 is an RNA chaperone important for mitochondrial group I and II intron splicing, translational activation, and RNA end processing. Mss116 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350722 [Multi-domain] Cd Length: 211 Bit Score: 183.55 E-value: 3.31e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 398 LPPHILEVIDKCGYKEPTPIQRQAIPIGLQNR-DIIGVAETGSGKTAAFLIPLL-VWITTLPKIDRieeSDQGpyAIILA 475
Cdd:cd17964 1 LDPSLLKALTRMGFETMTPVQQKTLKPILSTGdDVLARAKTGTGKTLAFLLPAIqSLLNTKPAGRR---SGVS--ALIIS 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 476 PTRELAQQIEEETIKFGKPL-GIRTVAVIGGISREDQGFRL-RMGCEIVIATPGRLIDVLENRYL--VLSRCTYVVLDEA 551
Cdd:cd17964 76 PTRELALQIAAEAKKLLQGLrKLRVQSAVGGTSRRAELNRLrRGRPDILVATPGRLIDHLENPGVakAFTDLDYLVLDEA 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41327771 552 DRMIDMGFEPDVQKILEHMPVSNQKPdtdeaedpekmlanfesgkhkyRQTVMFTATMPPAVERLARSYLR 622
Cdd:cd17964 156 DRLLDMGFRPDLEQILRHLPEKNADP----------------------RQTLLFSATVPDEVQQIARLTLK 204
|
|
| DEADc_DDX24 |
cd17946 |
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box ... |
402-609 |
2.68e-52 |
|
DEAD-box helicase domain of DEAD box protein 24; The human DDX24 gene encodes a DEAD box protein, which shows little similarity to any of the other known human DEAD box proteins, but shows a high similarity to mouse Ddx24 at the amino acid level. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. DDX24 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350704 [Multi-domain] Cd Length: 235 Bit Score: 182.05 E-value: 2.68e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNR-DIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEESDQGPYAIILAPTREL 480
Cdd:cd17946 1 ILRALADLGFSEPTPIQALALPAAIRDGkDVIGAAETGSGKTLAFGIPILERLLSQKSSNGVGGKQKPLRALILTPTREL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 481 AQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLE--NRYLV-LSRCTYVVLDEADRMIDM 557
Cdd:cd17946 81 AVQVKDHLKAIAKYTNIKIASIVGGLAVQKQERLLKKRPEIVVATPGRLWELIQegNEHLAnLKSLRFLVLDEADRMLEK 160
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 41327771 558 GFEPDVQKILEHMPVSNQkpdtdeaedpekmlanfesGKHKYRQTVMFTATM 609
Cdd:cd17946 161 GHFAELEKILELLNKDRA-------------------GKKRKRQTFVFSATL 193
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
406-642 |
4.24e-52 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 180.38 E-value: 4.24e-52
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 406 IDKCGYKEPTPIQRQAIPIGLQN-RDIIGVAETGSGKTAAFLIPLLvwittlpkidRIEESDQGPYAIILAPTRELAQQI 484
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGlRDVILAAPTGSGKTLAALLPAL----------EALKRGKGGRVLVLVPTRELAEQW 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 485 EEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGC-EIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDV 563
Cdd:smart00487 71 AEELKKLGPSLGLKVVGLYGGDSKREQLRKLESGKtDILVTTPGRLLDLLENDKLSLSNVDLVILDEAHRLLDGGFGDQL 150
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 41327771 564 QKILEHMPvsnqkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSagKPHERVEQK 642
Cdd:smart00487 151 EKLLKLLP--------------------------KNVQLLLLSATPPEEIENLLELFLNDPVFIDVGF--TPLEPIEQF 201
|
|
| DEADc_DDX55 |
cd17960 |
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, ... |
402-627 |
1.21e-51 |
|
DEAD-box helicase domain of DEAD box protein 55; DDX55 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350718 [Multi-domain] Cd Length: 202 Bit Score: 178.92 E-value: 1.21e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwiTTLPKiDRIEESDQGPYAIILAPTRELA 481
Cdd:cd17960 1 ILDVVAELGFTSMTPVQAATIPLFLSNKDVVVEAVTGSGKTLAFLIPVL---EILLK-RKANLKKGQVGALIISPTRELA 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 482 QQIEEETIKFGKPLG--IRTVAVIGG--ISREDQGFRlRMGCEIVIATPGRLIDVLENRYLV--LSRCTYVVLDEADRMI 555
Cdd:cd17960 77 TQIYEVLQSFLEHHLpkLKCQLLIGGtnVEEDVKKFK-RNGPNILVGTPGRLEELLSRKADKvkVKSLEVLVLDEADRLL 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41327771 556 DMGFEPDVQKILEHMPvsnqkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAVERLARSYLRRPAVV 627
Cdd:cd17960 156 DLGFEADLNRILSKLP--------------------------KQRRTGLFSATQTDAVEELIKAGLRNPVRV 201
|
|
| DEADc_DDX6 |
cd17940 |
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or ... |
393-624 |
4.57e-49 |
|
DEAD-box helicase domain of DEAD box protein 6; DEAD box protein 6 (DDX6, also known as Rck or p54) participates in mRNA regulation mediated by miRNA-mediated silencing. It also plays a role in global and transcript-specific messenger RNA (mRNA) storage, translational repression, and decay. It is a member of the DEAD-box helicase family, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350698 [Multi-domain] Cd Length: 201 Bit Score: 171.71 E-value: 4.57e-49
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 393 WKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQGPYAI 472
Cdd:cd17940 1 FEDYGLKRELLMGIFEKGFEKPSPIQEESIPIALSGRDILARAKNGTGKTGAYLIPIL---------EKIDPKKDVIQAL 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 473 ILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEAD 552
Cdd:cd17940 72 ILVPTRELALQTSQVCKELGKHMGVKVMVTTGGTSLRDDIMRLYQTVHVLVGTPGRILDLAKKGVADLSHCKTLVLDEAD 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41327771 553 RMIDMGFEPDVQKILEHMPvsnqkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAVERLARSYLRRP 624
Cdd:cd17940 152 KLLSQDFQPIIEKILNFLP--------------------------KERQILLFSATFPLTVKNFMDRHMHNP 197
|
|
| DEADc_DDX59 |
cd17962 |
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer ... |
406-627 |
4.47e-48 |
|
DEAD-box helicase domain of DEAD box protein 59; DDX59 plays an important role in lung cancer development by promoting DNA replication. DDX59 knockdown mice showed reduced cell proliferation, anchorage-independent cell growth, and reduction of tumor formation. Recent work shows that EGFR and Ras regulate DDX59 during lung cancer development. Diseases associated with DDX59 (also called zinc finger HIT domain-containing protein 5) include orofaciodigital syndrome V and orofaciodigital syndrome. DDX59 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350720 [Multi-domain] Cd Length: 193 Bit Score: 168.88 E-value: 4.47e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 406 IDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLlvwittlpkIDRIEESDQGPYAIILAPTRELAQQIE 485
Cdd:cd17962 5 LKKAGYEVPTPIQMQMIPVGLLGRDILASADTGSGKTAAFLLPV---------IIRCLTEHRNPSALILTPTRELAVQIE 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 486 EETIKFGKPL-GIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQ 564
Cdd:cd17962 76 DQAKELMKGLpPMKTALLVGGLPLPPQLYRLQQGVKVIIATPGRLLDILKQSSVELDNIKIVVVDEADTMLKMGFQQQVL 155
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 41327771 565 KILEHMPvsnqkpdtdeaEDPekmlanfesgkhkyrQTVMFTATMPPAVERLARSYLRRPAVV 627
Cdd:cd17962 156 DILENIS-----------HDH---------------QTILVSATIPRGIEQLAGQLLQNPVRI 192
|
|
| DEADc_DDX10 |
cd17941 |
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin ... |
410-630 |
1.60e-46 |
|
DEAD-box helicase domain of DEAD box protein 10; Fusion of the DDX10 gene and the nucleoporin gene, NUP98, by inversion 11 (p15q22) chromosome translocation is found in the patients with de novo or therapy-related myeloid malignancies. Diseases associated with DDX10 (also known as DDX10-NUP98 Fusion Protein Type 2) include myelodysplastic syndrome and leukemia, acute myeloid. DDX10 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350699 [Multi-domain] Cd Length: 198 Bit Score: 164.77 E-value: 1.60e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 410 GYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLlvwittLPKIDRIE-ESDQGPYAIILAPTRELAQQIEEET 488
Cdd:cd17941 9 GFIKMTEIQRDSIPHALQGRDILGAAKTGSGKTLAFLVPL------LEKLYRERwTPEDGLGALIISPTRELAMQIFEVL 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 489 IKFGKPLGIRTVAVIGGISREDQgfRLRMG-CEIVIATPGRLIDVL-ENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKI 566
Cdd:cd17941 83 RKVGKYHSFSAGLIIGGKDVKEE--KERINrMNILVCTPGRLLQHMdETPGFDTSNLQMLVLDEADRILDMGFKETLDAI 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41327771 567 LEHMPvsnqkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAVERLARSYLRRPavVYIG 630
Cdd:cd17941 161 VENLP--------------------------KSRQTLLFSATQTKSVKDLARLSLKNP--EYIS 196
|
|
| DEADc_DDX56 |
cd17961 |
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of ... |
398-627 |
7.53e-46 |
|
DEAD-box helicase domain of DEAD box protein 56; DDX56 is a helicase required for assembly of infectious West Nile virus particles. New research suggests that DDX56 relocalizes to the site of virus assembly during WNV infection and that its interaction with WNV capsid in the cytoplasm may occur transiently during virion morphogenesis. DDX56 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350719 [Multi-domain] Cd Length: 206 Bit Score: 163.14 E-value: 7.53e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 398 LPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRIEesdQGPYAIILAPT 477
Cdd:cd17961 1 LDPRLLKAIAKLGWEKPTLIQSKAIPLALEGKDILARARTGSGKTAAYALPIIQKILKAKAESGEE---QGTRALILVPT 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 478 RELAQQ----IEEETIKFGKPlgIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLE-NRYLVLSRCTYVVLDEAD 552
Cdd:cd17961 78 RELAQQvskvLEQLTAYCRKD--VRVVNLSASSSDSVQRALLAEKPDIVVSTPARLLSHLEsGSLLLLSTLKYLVIDEAD 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41327771 553 RMIDMGFEPDVQKILEHMPvsnqkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAVERLARSYLRRPAVV 627
Cdd:cd17961 156 LVLSYGYEEDLKSLLSYLP--------------------------KNYQTFLMSATLSEDVEALKKLVLHNPAIL 204
|
|
| DEADc_DDX18 |
cd17942 |
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein ... |
402-630 |
6.09e-42 |
|
DEAD-box helicase domain of DEAD box protein 18; This DDX18 gene encodes a DEAD box protein and is activated by Myc protein. DDX18 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350700 [Multi-domain] Cd Length: 198 Bit Score: 151.74 E-value: 6.09e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPKIDRieesdQGPYAIILAPTRELA 481
Cdd:cd17942 1 TLKAIEEMGFTKMTEIQAKSIPPLLEGRDVLGAAKTGSGKTLAFLIPAIELLYKLKFKPR-----NGTGVIIISPTRELA 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 482 QQIE---EETIKFG-KPLGIrtvaVIGGISREDQGFRLRMGCEIVIATPGRLIDVLEN-RYLVLSRCTYVVLDEADRMID 556
Cdd:cd17942 76 LQIYgvaKELLKYHsQTFGI----VIGGANRKAEAEKLGKGVNILVATPGRLLDHLQNtKGFLYKNLQCLIIDEADRILE 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41327771 557 MGFEPDVQKILEHMPvsnqkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAVERLARSYLRRPAvVYIG 630
Cdd:cd17942 152 IGFEEEMRQIIKLLP--------------------------KRRQTMLFSATQTRKVEDLARISLKKKP-LYVG 198
|
|
| DEADc_EIF4A |
cd17939 |
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation ... |
410-624 |
5.97e-41 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A; The eukaryotic initiation factor-4A (eIF4A) family consists of 3 proteins EIF4A1, EIF4A2, and EIF4A3. These factors are required for the binding of mRNA to 40S ribosomal subunits. In addition these proteins are helicases that function to unwind double-stranded RNA. EIF4A proteins are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350697 [Multi-domain] Cd Length: 199 Bit Score: 149.01 E-value: 5.97e-41
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 410 GYKEPTPIQRQAI-PIgLQNRDIIGVAETGSGKTAAFLIpllvwiTTLPKIDRIEESDQgpyAIILAPTRELAQQIEEET 488
Cdd:cd17939 16 GFEKPSAIQQRAIvPI-IKGRDVIAQAQSGTGKTATFSI------GALQRIDTTVRETQ---ALVLAPTRELAQQIQKVV 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 489 IKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILE 568
Cdd:cd17939 86 KALGDYMGVKVHACIGGTSVREDRRKLQYGPHIVVGTPGRVFDMLQRRSLRTDKIKMFVLDEADEMLSRGFKDQIYDIFQ 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 41327771 569 HMPvsnqkPDTdeaedpekmlanfesgkhkyrQTVMFTATMPPAVERLARSYLRRP 624
Cdd:cd17939 166 FLP-----PET---------------------QVVLFSATMPHEVLEVTKKFMRDP 195
|
|
| DEADc_EIF4AII_EIF4AI_DDX2 |
cd18046 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation ... |
395-624 |
2.27e-39 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-I and 4-II; Eukaryotic initiation factor 4A-I (DDX2A) and eukaryotic initiation factor 4A-II (DDX2B) are involved in cap recognition and are required for mRNA binding to ribosome. They are DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350804 [Multi-domain] Cd Length: 201 Bit Score: 144.51 E-value: 2.27e-39
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 395 DSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQGPYAIIL 474
Cdd:cd18046 3 DMNLKESLLRGIYAYGFEKPSAIQQRAIMPCIKGYDVIAQAQSGTGKTATFSISIL---------QQIDTSLKATQALVL 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 475 APTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRM 554
Cdd:cd18046 74 APTRELAQQIQKVVMALGDYMGIKCHACIGGTSVRDDAQKLQAGPHIVVGTPGRVFDMINRRYLRTDYIKMFVLDEADEM 153
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 555 IDMGFEPDVQKILEHMPvsnqkPDTdeaedpekmlanfesgkhkyrQTVMFTATMPPAVERLARSYLRRP 624
Cdd:cd18046 154 LSRGFKDQIYDIFQKLP-----PDT---------------------QVVLLSATMPNDVLEVTTKFMRDP 197
|
|
| DEADc_DDX20 |
cd17943 |
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, ... |
402-627 |
1.17e-38 |
|
DEAD-box helicase domain of DEAD box protein 20; DDX20 (also called DEAD Box Protein DP 103, Component Of Gems 3, Gemin-3, and SMN-Interacting Protein) interacts directly with SMN (survival of motor neurons), the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on ribonucleoproteins. Diseases associated with DDX20 include spinal muscular atrophy and muscular atrophy. DDX20 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350701 [Multi-domain] Cd Length: 192 Bit Score: 142.02 E-value: 1.17e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQGPYAIILAPTRELA 481
Cdd:cd17943 1 VLEGLKAAGFQRPSPIQLAAIPLGLAGHDLIVQAKSGTGKTLVFVVIAL---------ESLDLERRHPQVLILAPTREIA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 482 QQIEEETIKFGKPL-GIRTVAVIGGISREDQGFRLRmGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFE 560
Cdd:cd17943 72 VQIHDVFKKIGKKLeGLKCEVFIGGTPVKEDKKKLK-GCHIAVGTPGRIKQLIELGALNVSHVRLFVLDEADKLMEGSFQ 150
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41327771 561 PDVQKILEHMPvsnqkpdtdeaedpekmlanfesgkhKYRQTVMFTATMPPAV-ERLARsYLRRPAVV 627
Cdd:cd17943 151 KDVNWIFSSLP--------------------------KNKQVIAFSATYPKNLdNLLAR-YMRKPVLV 191
|
|
| DEADc_DDX1 |
cd17938 |
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ... |
400-627 |
2.77e-38 |
|
DEAD-box helicase domain of DEAD box protein 1; DEAD box protein 1 (DDX1) acts as an ATP-dependent RNA helicase, able to unwind both RNA-RNA and RNA-DNA duplexes. It possesses 5' single-stranded RNA overhang nuclease activity as well as ATPase activity on various RNA, but not DNA polynucleotides. DDX1 may play a role in RNA clearance at DNA double-strand breaks (DSBs), thereby facilitating the template-guided repair of transcriptionally active regions of the genome. It may also be involved in 3'-end cleavage and polyadenylation of pre-mRNAs. DDX1 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350696 [Multi-domain] Cd Length: 204 Bit Score: 141.69 E-value: 2.77e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 400 PHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkidrieesdQGPYAIILAPTRE 479
Cdd:cd17938 8 PELIKAVEELDWLLPTDIQAEAIPLILGGGDVLMAAETGSGKTGAFCLPVL----------------QIVVALILEPSRE 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 480 LAQQIEEETIKFGKPL---GIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMID 556
Cdd:cd17938 72 LAEQTYNCIENFKKYLdnpKLRVALLIGGVKAREQLKRLESGVDIVVGTPGRLEDLIKTGKLDLSSVRFFVLDEADRLLS 151
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 41327771 557 MGFEPDVQKILEHMPvsnqKPDTDEaedpekmlanfesgkhKYRQTVMFTATM-PPAVERLARSYLRRPAVV 627
Cdd:cd17938 152 QGNLETINRIYNRIP----KITSDG----------------KRLQVIVCSATLhSFEVKKLADKIMHFPTWV 203
|
|
| DEADc_DDX39 |
cd17950 |
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and ... |
392-629 |
2.77e-38 |
|
DEAD-box helicase domain of DEAD box protein 39; DDX39A is involved in pre-mRNA splicing and is required for the export of mRNA out of the nucleus. DDX39B is an essential splicing factor required for association of U2 small nuclear ribonucleoprotein with pre-mRNA, and it also plays an important role in mRNA export from the nucleus to the cytoplasm. Diseases associated with DDX39A (also called UAP56-Related Helicase, 49 kDa) include gastrointestinal stromal tumor and inflammatory bowel disease 6, while diseases associated with DDX39B (also called 56 kDa U2AF65-Associated Protein) include Plasmodium vivax malaria. DDX39 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350708 [Multi-domain] Cd Length: 208 Bit Score: 141.71 E-value: 2.77e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 392 SWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQGPYA 471
Cdd:cd17950 3 GFRDFLLKPELLRAIVDCGFEHPSEVQHECIPQAILGMDVLCQAKSGMGKTAVFVLSTL---------QQLEPVDGQVSV 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 472 IILAPTRELAQQIEEETIKFGKPL-GIRTVAVIGGIS-REDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLD 549
Cdd:cd17950 74 LVICHTRELAFQISNEYERFSKYMpNVKTAVFFGGVPiKKDIEVLKNKCPHIVVGTPGRILALVREKKLKLSHVKHFVLD 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 550 EADRMI-DMGFEPDVQKIlehmpvsnqkpdtdeaedpekmlanFESGKHKyRQTVMFTATMPPAVERLARSYLRRPAVVY 628
Cdd:cd17950 154 ECDKMLeQLDMRRDVQEI-------------------------FRATPHD-KQVMMFSATLSKEIRPVCKKFMQDPLEIF 207
|
.
gi 41327771 629 I 629
Cdd:cd17950 208 V 208
|
|
| DEADc_DDX19_DDX25 |
cd17963 |
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called ... |
398-620 |
2.91e-35 |
|
DEAD-box helicase domain of ATP-dependent RNA helicases DDX19 and DDX25; DDX19 (also called DEAD box RNA helicase DEAD5) and DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH)) are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350721 [Multi-domain] Cd Length: 196 Bit Score: 132.70 E-value: 2.91e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 398 LPPHILEVIDKCGYKEPTPIQRQAIPIGLQN--RDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQGPYAIILA 475
Cdd:cd17963 1 LKPELLKGLYAMGFNKPSKIQETALPLILSDppENLIAQSQSGTGKTAAFVLAML---------SRVDPTLKSPQALCLA 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 476 PTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDqgfRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMI 555
Cdd:cd17963 72 PTRELARQIGEVVEKMGKFTGVKVALAVPGNDVPR---GKKITAQIVIGTPGTVLDWLKKRQLDLKKIKILVLDEADVML 148
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41327771 556 DM-GFEPDVQKILEHMPvsnqkPDTdeaedpekmlanfesgkhkyrQTVMFTATMPPAVERLARSY 620
Cdd:cd17963 149 DTqGHGDQSIRIKRMLP-----RNC---------------------QILLFSATFPDSVRKFAEKI 188
|
|
| DEADc_DDX28 |
cd17948 |
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box ... |
402-616 |
3.68e-35 |
|
DEAD-box helicase domain of DEAD box protein 28; DDX28 (also called mitochondrial DEAD-box polypeptide 28) plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. DDX28 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350706 [Multi-domain] Cd Length: 231 Bit Score: 133.65 E-value: 3.68e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLlvwittLPKIDRIEESDQGPY----AIILAPT 477
Cdd:cd17948 1 LVEILQRQGITKPTTVQKQGIPSILRGRNTLCAAETGSGKTLTYLLPI------IQRLLRYKLLAEGPFnaprGLVITPS 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 478 RELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDM 557
Cdd:cd17948 75 RELAEQIGSVAQSLTEGLGLKVKVITGGRTKRQIRNPHFEEVDILVATPGALSKLLTSRIYSLEQLRHLVLDEADTLLDD 154
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 558 GFEPDVQKILEHMPV-SNQKPDTDEaedpEKMLAnfesgkhkyrQTVMFTATMPPAVERL 616
Cdd:cd17948 155 SFNEKLSHFLRRFPLaSRRSENTDG----LDPGT----------QLVLVSATMPSGVGEV 200
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
650-759 |
5.11e-34 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 125.79 E-value: 5.11e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 650 EKRKKLLAILEQGFDPPIIIFVNQKKGCDvLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGID 729
Cdd:pfam00271 1 EKLEALLELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLD 79
|
90 100 110
....*....|....*....|....*....|
gi 41327771 730 IQDVSMVVNYDMAKNIEDYIHRIGRTGRAG 759
Cdd:pfam00271 80 LPDVDLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEADc_EIF4AIII_DDX48 |
cd18045 |
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor ... |
397-575 |
2.10e-29 |
|
DEAD-box helicase domain of eukaryotic initiation factor 4A-III; Eukaryotic initiation factor 4A-III (EIF4AIII, also known as DDX48) is part of the exon junction complex (EJC) that plays a major role in posttranscriptional regulation of mRNA. EJC consists of four proteins (eIF4AIII, Barentsz [Btz], Mago, and Y14), mRNA, and ATP. DDX48 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350803 [Multi-domain] Cd Length: 201 Bit Score: 116.03 E-value: 2.10e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 397 SLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQGPYAIILAP 476
Cdd:cd18045 5 GLREDLLRGIYAYGFEKPSAIQQRAIKPIIKGRDVIAQSQSGTGKTATFSISVL---------QCLDIQVRETQALILSP 75
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 477 TRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMID 556
Cdd:cd18045 76 TRELAVQIQKVLLALGDYMNVQCHACIGGTSVGDDIRKLDYGQHIVSGTPGRVFDMIRRRSLRTRHIKMLVLDEADEMLN 155
|
170
....*....|....*....
gi 41327771 557 MGFEPDVQKILEHMPVSNQ 575
Cdd:cd18045 156 KGFKEQIYDVYRYLPPATQ 174
|
|
| DEADc_DDX21_DDX50 |
cd17944 |
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and ... |
416-622 |
3.44e-29 |
|
DEAD-box helicase domain of DEAD box proteins 21 and 50; DDX21 (also called Gu-Alpha and nucleolar RNA helicase 2) is an RNA helicase that acts as a sensor of the transcriptional status of both RNA polymerase (Pol) I and II. It promotes ribosomal RNA (rRNA) processing and transcription from polymerase II (Pol II) and binds various RNAs, such as rRNAs, snoRNAs, 7SK and, at lower extent, mRNAs. DDX50 (also called Gu-Beta, Nucleolar Protein Gu2, and malignant cell derived RNA helicase). DDX21 and DDX50 have similar genomic structures and are in tandem orientation on chromosome 10, suggesting that the two genes arose by gene duplication in evolution. Diseases associated with DDX21 include stomach disease and cerebral creatine deficiency syndrome 3. Diseases associated with DDX50 include rectal disease. Both are members of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. Their name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP- binding region.
Pssm-ID: 350702 [Multi-domain] Cd Length: 202 Bit Score: 115.33 E-value: 3.44e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 416 PIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLlvwittlpkIDRIEESDQ------GPYAIILAPTRELAQQIEEETI 489
Cdd:cd17944 15 PIQVKTFHPVYSGKDLIAQARTGTGKTFSFAIPL---------IEKLQEDQQprkrgrAPKVLVLAPTRELANQVTKDFK 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 490 KFGKPLGIrtVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEh 569
Cdd:cd17944 86 DITRKLSV--ACFYGGTPYQQQIFAIRNGIDILVGTPGRIKDHLQNGRLDLTKLKHVVLDEVDQMLDMGFAEQVEEILS- 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|...
gi 41327771 570 mpVSNQKpdtDEAEDPekmlanfesgkhkyrQTVMFTATMPPAVERLARSYLR 622
Cdd:cd17944 163 --VSYKK---DSEDNP---------------QTLLFSATCPDWVYNVAKKYMK 195
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
678-759 |
1.89e-28 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 108.84 E-value: 1.89e-28
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 678 DVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGR 757
Cdd:smart00490 1 EELAELLKELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGR 80
|
..
gi 41327771 758 AG 759
Cdd:smart00490 81 AG 82
|
|
| DEADc_DDX51 |
cd17956 |
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by ... |
402-624 |
2.81e-27 |
|
DEAD-box helicase domain of DEAD box protein 51; DDX51 aids cell cancer proliferation by regulating multiple signalling pathways. Mammalian DEAD box protein Ddx51 acts in 3' end maturation of 28S rRNA by promoting the release of U8 snoRNA.It is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350714 [Multi-domain] Cd Length: 231 Bit Score: 110.80 E-value: 2.81e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 402 ILEVIDKCGYKEPTPIQRQAIP---------IGLQNRDIIGVAETGSGKTAAFLIPLLVWITTLPkIDRIEesdqgpyAI 472
Cdd:cd17956 1 LLKNLQNNGITSAFPVQAAVIPwllpsskstPPYRPGDLCVSAPTGSGKTLAYVLPIVQALSKRV-VPRLR-------AL 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 473 ILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGIS--------REDQGFRLRMGCEIVIATPGRLIDVL-ENRYLVLSRC 543
Cdd:cd17956 73 IVVPTKELVQQVYKVFESLCKGTGLKVVSLSGQKSfkkeqkllLVDTSGRYLSRVDILVATPGRLVDHLnSTPGFTLKHL 152
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 544 TYVVLDEADRMIDMGFEPDVQKILEHMpvsnqkpDTDEAEDPekmlANFESGKHKYR-----QTVMFTATMPPAVERLAR 618
Cdd:cd17956 153 RFLVIDEADRLLNQSFQDWLETVMKAL-------GRPTAPDL----GSFGDANLLERsvrplQKLLFSATLTRDPEKLSS 221
|
....*.
gi 41327771 619 SYLRRP 624
Cdd:cd17956 222 LKLHRP 227
|
|
| DEADc_MRH4 |
cd17965 |
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 ... |
398-575 |
1.07e-25 |
|
DEAD-box helicase domain of ATP-dependent RNA helicase MRH4; Mitochondrial RNA helicase 4 (MRH4) plays an essential role during the late stages of mitochondrial ribosome or mitoribosome assembly by promoting remodeling of the 21S rRNA-protein interactions. MRH4 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350723 [Multi-domain] Cd Length: 251 Bit Score: 106.69 E-value: 1.07e-25
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 398 LPP---HILEVIDK-----CGYKEPTPIQRQAIPIGLQNRDIIG----------------VAETGSGKTAAFLIPLLVWI 453
Cdd:cd17965 7 LPSvreAIIKEILKgsnktDEEIKPSPIQTLAIKKLLKTLMRKVtkqtsneepklevfllAAETGSGKTLAYLAPLLDYL 86
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 454 ttlpKIDRIEESDQG------------PYAIILAPTRELAQQIEEETIKFGKP--LGIRTVAVIGGISREDQGFRLRMGC 519
Cdd:cd17965 87 ----KRQEQEPFEEAeeeyesakdtgrPRSVILVPTHELVEQVYSVLKKLSHTvkLGIKTFSSGFGPSYQRLQLAFKGRI 162
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*.
gi 41327771 520 EIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQ 575
Cdd:cd17965 163 DILVTTPGKLASLAKSRPKILSRVTHLVVDEADTLFDRSFLQDTTSIIKRAPKLKH 218
|
|
| RecQ |
COG0514 |
Superfamily II DNA helicase RecQ [Replication, recombination and repair]; |
605-772 |
4.82e-21 |
|
Superfamily II DNA helicase RecQ [Replication, recombination and repair];
Pssm-ID: 440280 [Multi-domain] Cd Length: 489 Bit Score: 97.52 E-value: 4.82e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 605 FTATMPPAV-----ERLArsyLRRPAVvYIGSAGKP--HERVEQKVflmsESEKRKKLLAILEQGFDPPIIIFVNQKKGC 677
Cdd:COG0514 172 LTATATPRVradiaEQLG---LEDPRV-FVGSFDRPnlRLEVVPKP----PDDKLAQLLDFLKEHPGGSGIVYCLSRKKV 243
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 678 DVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATdVA-GRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTG 756
Cdd:COG0514 244 EELAEWLREAGIRAAAYHAGLDAEEREANQDRFLRDEVDVIVAT-IAfGMGIDKPDVRFVIHYDLPKSIEAYYQEIGRAG 322
|
170
....*....|....*.
gi 41327771 757 RAGKSGVAITFLTKED 772
Cdd:COG0514 323 RDGLPAEALLLYGPED 338
|
|
| DEADc_DDX25 |
cd18048 |
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated ... |
390-575 |
2.06e-18 |
|
DEAD-box helicase domain of DEAD box protein 25; DDX25 (also called gonadotropin-regulated testicular RNA helicase (GRTH) is a testis-specific protein essential for completion of spermatogenesis. DDX25 is also a novel negative regulator of IFN pathway and facilitates RNA virus infection. Diseases associated with DDX25 include hydrolethalus syndrome, an autosomal recessive lethal malformation syndrome characterized by multiple developmental defects of fetus.. DDX25 (also called gonadotropin-regulated testicular RNA helicase) is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350806 [Multi-domain] Cd Length: 229 Bit Score: 85.07 E-value: 2.06e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 390 IRSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQN--RDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQ 467
Cdd:cd18048 17 VKSFEELHLKEELLRGIYAMGFNRPSKIQENALPMMLADppQNLIAQSQSGTGKTAAFVLAML---------SRVDALKL 87
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 468 GPYAIILAPTRELAQQ---IEEETIKFGkpLGIRTVAVIGGiSREDQGFRLRMgcEIVIATPGRLID-VLENRYLVLSRC 543
Cdd:cd18048 88 YPQCLCLSPTFELALQtgkVVEEMGKFC--VGIQVIYAIRG-NRPGKGTDIEA--QIVIGTPGTVLDwCFKLRLIDVTNI 162
|
170 180 190
....*....|....*....|....*....|...
gi 41327771 544 TYVVLDEADRMIDM-GFEPDVQKILEHMPVSNQ 575
Cdd:cd18048 163 SVFVLDEADVMINVqGHSDHSVRVKRSMPKECQ 195
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
413-779 |
4.62e-17 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 85.46 E-value: 4.62e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 413 EPTPIQRQAI-----PIGLQNRDIIGVAETGSGKT--AAFLIpllvwittlpkidriEESDQGPYAIILAPTRELAQQIE 485
Cdd:COG1061 80 ELRPYQQEALeallaALERGGGRGLVVAPTGTGKTvlALALA---------------AELLRGKRVLVLVPRRELLEQWA 144
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 486 EETIKFgkplgiRTVAVIGGISREDqgfrlrmGCEIVIATPGRLIDVLENRYLVlSRCTYVVLDEADRMIDMGFepdvQK 565
Cdd:COG1061 145 EELRRF------LGDPLAGGGKKDS-------DAPITVATYQSLARRAHLDELG-DRFGLVIIDEAHHAGAPSY----RR 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 566 ILEHMPvsnqkpdtdeaedPEKMLA-----NFESGKHKYRQT---VMFTATMPPAverLARSYLRRPAVVYI-------G 630
Cdd:COG1061 207 ILEAFP-------------AAYRLGltatpFRSDGREILLFLfdgIVYEYSLKEA---IEDGYLAPPEYYGIrvdltdeR 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 631 SAGKPHERVEQKVFLMSESEKRKKLLAILEQ-GFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSN 709
Cdd:COG1061 271 AEYDALSERLREALAADAERKDKILRELLREhPDDRKTLVFCSSVDHAEALAELLNEAGIRAAVVTGDTPKKEREEILEA 350
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 710 LKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGvaitfltkeDSAVFYEL 779
Cdd:COG1061 351 FRDGELRILVTVDVLNEGVDVPRLDVAILLRPTGSPREFIQRLGRGLRPAPGK---------EDALVYDF 411
|
|
| SF2_C_RecQ |
cd18794 |
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an ... |
647-767 |
9.25e-16 |
|
C-terminal helicase domain of the RecQ family helicases; The RecQ helicase family is an evolutionarily conserved class of enzymes, dedicated to preserving genomic integrity by operating in telomere maintenance, DNA repair, and replication. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350181 [Multi-domain] Cd Length: 134 Bit Score: 74.55 E-value: 9.25e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 647 SESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGR 726
Cdd:cd18794 13 KKDEKLDLLKRIKVEHLGGSGIIYCLSRKECEQVAARLQSKGISAAAYHAGLEPSDRRDVQRKWLRDKIQVIVATVAFGM 92
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 41327771 727 GIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITF 767
Cdd:cd18794 93 GIDKPDVRFVIHYSLPKSMESYYQESGRAGRDGLPSECILF 133
|
|
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
398-551 |
2.20e-14 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 76.86 E-value: 2.20e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 398 LPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGV-AETGSGKTaafLIPLLVWITTLpkidrieesDQGPYAIILAP 476
Cdd:COG1204 7 PLEKVIEFLKERGIEELYPPQAEALEAGLLEGKNLVVsAPTASGKT---LIAELAILKAL---------LNGGKALYIVP 74
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41327771 477 TRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRlrmGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEA 551
Cdd:COG1204 75 LRALASEKYREFKRDFEELGIKVGVSTGDYDSDDEWLG---RYDILVATPEKLDSLLRNGPSWLRDVDLVVVDEA 146
|
|
| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
666-769 |
2.90e-14 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 68.50 E-value: 2.90e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 666 PIIIFVNQKKGCDVLAKSLEkmgynactlhggkgqeqrefalsnlkagakdILVATDVAGRGIDIQDVSMVVNYDMAKNI 745
Cdd:cd18785 5 KIIVFTNSIEHAEEIASSLE-------------------------------ILVATNVLGEGIDVPSLDTVIFFDPPSSA 53
|
90 100
....*....|....*....|....
gi 41327771 746 EDYIHRIGRTGRAGKSGVAITFLT 769
Cdd:cd18785 54 ASYIQRVGRAGRGGKDEGEVILFV 77
|
|
| MPH1 |
COG1111 |
ERCC4-related helicase [Replication, recombination and repair]; |
648-781 |
1.16e-13 |
|
ERCC4-related helicase [Replication, recombination and repair];
Pssm-ID: 440728 [Multi-domain] Cd Length: 718 Bit Score: 74.77 E-value: 1.16e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 648 ESEKRKKLLAILEQGF----DPPIIIFVNQKKGCDVLAKSLEKMGYNACTL------HGGKG--QEQREFALSNLKAGAK 715
Cdd:COG1111 333 EHPKLSKLREILKEQLgtnpDSRIIVFTQYRDTAEMIVEFLSEPGIKAGRFvgqaskEGDKGltQKEQIEILERFRAGEF 412
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 41327771 716 DILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGR--AGKSGVAITFLTKeDSAVFYELKQ 781
Cdd:COG1111 413 NVLVATSVAEEGLDIPEVDLVIFYEPVPSEIRSIQRKGRTGRkrEGRVVVLIAKGTR-DEAYYWSSRR 479
|
|
| DEADc_DDX19 |
cd18047 |
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both ... |
391-555 |
1.01e-11 |
|
DEAD-box helicase domain of DEAD box protein 19; DDX19 is an RNA helicase involved in both mRNA (mRNA) export from the nucleus into the cytoplasm and in mRNA translation. DDX19 functions in the nucleus in resolving RNA:DNA hybrids (R-loops). Activation of a DNA damage response pathway dependent upon the ATR kinase, a major regulator of replication fork progression, stimulates translocation of DDX19 from the cytoplasm into the nucleus. Only nuclear Ddx19 is competent to resolve R-loops. DDX19 is a member of the DEAD-box helicases, a diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif (motif II). This domain contains the ATP-binding region.
Pssm-ID: 350805 [Multi-domain] Cd Length: 205 Bit Score: 65.13 E-value: 1.01e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 391 RSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQN--RDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEESDQG 468
Cdd:cd18047 1 KSFEELRLKPQLLQGVYAMGFNRPSKIQENALPLMLAEppQNLIAQSQSGTGKTAAFVLAML---------SQVEPANKY 71
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 469 PYAIILAPTRELAQQIEEETIKFGKPLGIRTVAVIGGISREDQGFRLRMgcEIVIATPGRLID-VLENRYLVLSRCTYVV 547
Cdd:cd18047 72 PQCLCLSPTYELALQTGKVIEQMGKFYPELKLAYAVRGNKLERGQKISE--QIVIGTPGTVLDwCSKLKFIDPKKIKVFV 149
|
....*...
gi 41327771 548 LDEADRMI 555
Cdd:cd18047 150 LDEADVMI 157
|
|
| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
434-569 |
3.98e-11 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 61.65 E-value: 3.98e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 434 VAETGSGKTAAFLIPLLvwittlpkiDRIEEsdQGPYAIILAPTRELAQQIEEETIKFGKPlGIRTVAVIGGISREDQGF 513
Cdd:cd00046 7 TAPTGSGKTLAALLAAL---------LLLLK--KGKKVLVLVPTKALALQTAERLRELFGP-GIRVAVLVGGSSAEEREK 74
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*..
gi 41327771 514 RLRMGCEIVIATPGRLI-DVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEH 569
Cdd:cd00046 75 NKLGDADIIIATPDMLLnLLLREDRLFLKDLKLIIVDEAHALLIDSRGALILDLAVR 131
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
415-551 |
5.22e-11 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 62.28 E-value: 5.22e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 415 TPIQRQAI-PIGLQNRDIIGVAETGSGKTaafLIPLLvWIttlpkIDRIEESDQgpYAIILAPTRELAQQIEEETIKFGK 493
Cdd:cd17921 3 NPIQREALrALYLSGDSVLVSAPTSSGKT---LIAEL-AI-----LRALATSGG--KAVYIAPTRALVNQKEADLRERFG 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 494 PLGIRTVAVIGGISREDQGFRlrmGCEIVIATPGRLiDVLENR--YLVLSRCTYVVLDEA 551
Cdd:cd17921 72 PLGKNVGLLTGDPSVNKLLLA---EADILVATPEKL-DLLLRNggERLIQDVRLVVVDEA 127
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
395-766 |
6.86e-11 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 66.01 E-value: 6.86e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 395 DSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIEEsDQGPYAIIL 474
Cdd:COG1205 38 PDWLPPELRAALKKRGIERLYSHQAEAIEAARAGKNVVIATPTASGKSLAYLLPVL---------EALLE-DPGATALYL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 475 APTRELAQQIEEETIKFGKPLGIR-TVAVI-GGISREDqgfR--LRMGCEIVIATPgrliDVLENRYL--------VLSR 542
Cdd:COG1205 108 YPTKALARDQLRRLRELAEALGLGvRVATYdGDTPPEE---RrwIREHPDIVLTNP----DMLHYGLLphhtrwarFFRN 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 543 CTYVVLDEA---------------DRMidmgfepdvQKILEHMpvsnqkpdtdeAEDPekmlanfesgkhkyrQTVMFTA 607
Cdd:COG1205 181 LRYVVIDEAhtyrgvfgshvanvlRRL---------RRICRHY-----------GSDP---------------QFILASA 225
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 608 TMPPAVErLARSYLRRPAVVyIGSAGKPHERveqKVFLM-------------SESEKRKKLLAILEQGFdpPIIIFVNQK 674
Cdd:COG1205 226 TIGNPAE-HAERLTGRPVTV-VDEDGSPRGE---RTFVLwnpplvddgirrsALAEAARLLADLVREGL--RTLVFTRSR 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 675 KGCDVLAKSLEK-----------MGYnactlHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAK 743
Cdd:COG1205 299 RGAELLARYARRalrepdladrvAAY-----RAGYLPEERREIERGLRSGELLGVVSTNALELGIDIGGLDAVVLAGYPG 373
|
410 420
....*....|....*....|...
gi 41327771 744 NIEDYIHRIGRTGRAGKSGVAIT 766
Cdd:COG1205 374 TRASFWQQAGRAGRRGQDSLVVL 396
|
|
| SF2_C_dicer |
cd18802 |
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave ... |
649-761 |
1.07e-10 |
|
C-terminal helicase domain of the endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicer exists throughout eukaryotes, and a subset has an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer helicase domains are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350189 [Multi-domain] Cd Length: 142 Bit Score: 60.30 E-value: 1.07e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 649 SEKRKKLLAILEQGFDPPI----IIFVNQKKGCDVLAKSLEKMG-----YNACTLHGG-------------KGQEQrefA 706
Cdd:cd18802 6 IPKLQKLIEILREYFPKTPdfrgIIFVERRATAVVLSRLLKEHPstlafIRCGFLIGRgnssqrkrslmtqRKQKE---T 82
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*
gi 41327771 707 LSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRtGRAGKS 761
Cdd:cd18802 83 LDKFRDGELNLLIATSVLEEGIDVPACNLVIRFDLPKTLRSYIQSRGR-ARAPNS 136
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
637-753 |
3.80e-10 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 58.64 E-value: 3.80e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 637 ERVEQKVflmseSEKRKKLLAILEQGFDPP--IIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGA 714
Cdd:cd18793 3 PKIEEVV-----SGKLEALLELLEELREPGekVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDP 77
|
90 100 110 120
....*....|....*....|....*....|....*....|....*..
gi 41327771 715 KD--ILVATDVAGRGIDIQDVSMVVNYDMAKNI------EDYIHRIG 753
Cdd:cd18793 78 DIrvFLLSTKAGGVGLNLTAANRVILYDPWWNPaveeqaIDRAHRIG 124
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
416-551 |
8.18e-09 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 55.00 E-value: 8.18e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 416 PIQRQAIPIGLQN----RDIIgVAETGSGKTA-AFLIPLLVWITTLpkidrieesdqgpyaIILAPTRELAQQIEEEtik 490
Cdd:cd17926 3 PYQEEALEAWLAHknnrRGIL-VLPTGSGKTLtALALIAYLKELRT---------------LIVVPTDALLDQWKER--- 63
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 41327771 491 FGKPLGIRTVAVIGGISREDQGfrlrmGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEA 551
Cdd:cd17926 64 FEDFLGDSSIGLIGGGKKKDFD-----DANVVVATYQSLSNLAEEEKDLFDQFGLLIVDEA 119
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
668-761 |
8.74e-09 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 54.96 E-value: 8.74e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 668 IIFVNQKKGCDVLAKSLEKMGYNACT-----LHGGK-GQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDM 741
Cdd:cd18796 42 LVFTNTRSQAERLAQRLRELCPDRVPpdfiaLHHGSlSRELREEVEAALKRGDLKVVVATSSLELGIDIGDVDLVIQIGS 121
|
90 100
....*....|....*....|
gi 41327771 742 AKNIEDYIHRIGRTGRAGKS 761
Cdd:cd18796 122 PKSVARLLQRLGRSGHRPGA 141
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
648-755 |
1.98e-08 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 57.93 E-value: 1.98e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 648 ESEKRKKLLAILEQGFDP--PIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAG--AKDILVATDV 723
Cdd:COG0553 531 RSAKLEALLELLEELLAEgeKVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGpeAPVFLISLKA 610
|
90 100 110
....*....|....*....|....*....|....*....
gi 41327771 724 AGRGIDIQDVSMVVNYDM----AKnIE---DYIHRIGRT 755
Cdd:COG0553 611 GGEGLNLTAADHVIHYDLwwnpAV-EEqaiDRAHRIGQT 648
|
|
| DEXHc_Hrq1-like |
cd17923 |
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a ... |
418-551 |
1.99e-08 |
|
DEAH-box helicase domain of Hrq1 and similar proteins; Yeast Hrq1, similar to RecQ4, plays a role in DNA inter-strand crosslink (ICL) repair and in telomere maintenance. Hrq1 lacks the Sld2-like domain found in RecQ4. Hrq1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350681 [Multi-domain] Cd Length: 182 Bit Score: 54.90 E-value: 1.99e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 418 QRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLvwittlpkiDRIeESDQGPYAIILAPTRELAQQIEEETIKFGKPLGI 497
Cdd:cd17923 5 QAEAIEAARAGRSVVVTTGTASGKSLCYQLPIL---------EAL-LRDPGSRALYLYPTKALAQDQLRSLRELLEQLGL 74
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41327771 498 R-TVAVIGG-ISREDQGFRLRMGCEIVIATPgrliDVLEnrYLVL----------SRCTYVVLDEA 551
Cdd:cd17923 75 GiRVATYDGdTPREERRAIIRNPPRILLTNP----DMLH--YALLphhdrwarflRNLRYVVLDEA 134
|
|
| DEXHc_dicer |
cd18034 |
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded ... |
429-551 |
6.18e-08 |
|
DEXH-box helicase domain of endoribonuclease Dicer; Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). In concert with Argonautes, these small RNAs bind complementary mRNAs to down-regulate their expression. miRNAs are processed by Dicer from small hairpins, while siRNAs are typically processed from longer dsRNA, from endogenous sources, or exogenous sources such as viral replication intermediates. Some organisms, such as Homo sapiens and Caenorhabditis elegans, encode one Dicer that generates miRNAs and siRNAs, but other organisms have multiple dicers with specialized functions. Dicers exist throughout eukaryotes, and a subset have an N-terminal helicase domain of the RIG-I-like receptor (RLR) subgroup. RLRs often function in innate immunity and Dicer helicase domains sometimes show differences in activity that correlate with roles in immunity. Dicer is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350792 [Multi-domain] Cd Length: 200 Bit Score: 53.81 E-value: 6.18e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 429 RDIIGVAETGSGKTaafLIPLLVwITTLPKIDRiEESDQGPYAIILAPTRELAQQiEEETIKFGKPLgirTVAVIGGISR 508
Cdd:cd18034 17 RNTIVVLPTGSGKT---LIAVML-IKEMGELNR-KEKNPKKRAVFLVPTVPLVAQ-QAEAIRSHTDL---KVGEYSGEMG 87
|
90 100 110 120
....*....|....*....|....*....|....*....|....*...
gi 41327771 509 EDQGFRLRMGCE-----IVIATPGRLIDVLENRYLVLSRCTYVVLDEA 551
Cdd:cd18034 88 VDKWTKERWKEElekydVLVMTAQILLDALRHGFLSLSDINLLIFDEC 135
|
|
| PLN03137 |
PLN03137 |
ATP-dependent DNA helicase; Q4-like; Provisional |
658-760 |
6.27e-08 |
|
ATP-dependent DNA helicase; Q4-like; Provisional
Pssm-ID: 215597 [Multi-domain] Cd Length: 1195 Bit Score: 56.44 E-value: 6.27e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 658 ILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVV 737
Cdd:PLN03137 674 IKENHFDECGIIYCLSRMDCEKVAERLQEFGHKAAFYHGSMDPAQRAFVQKQWSKDEINIICATVAFGMGINKPDVRFVI 753
|
90 100
....*....|....*....|...
gi 41327771 738 NYDMAKNIEDYIHRIGRTGRAGK 760
Cdd:PLN03137 754 HHSLPKSIEGYHQECGRAGRDGQ 776
|
|
| PRK11057 |
PRK11057 |
ATP-dependent DNA helicase RecQ; Provisional |
397-774 |
1.23e-07 |
|
ATP-dependent DNA helicase RecQ; Provisional
Pssm-ID: 182933 [Multi-domain] Cd Length: 607 Bit Score: 55.10 E-value: 1.23e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 397 SLPPHILEviDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVwittlpkidrieesdQGPYAIILAP 476
Cdd:PRK11057 11 SLAKQVLQ--ETFGYQQFRPGQQEIIDAVLSGRDCLVVMPTGGGKSLCYQIPALV---------------LDGLTLVVSP 73
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 477 TRELAQ-QIEEEtikfgKPLGIRTVAVIGGISREDQgFRLRMGC-----EIVIATPGRL-----IDVLENRYLVLsrcty 545
Cdd:PRK11057 74 LISLMKdQVDQL-----LANGVAAACLNSTQTREQQ-LEVMAGCrtgqiKLLYIAPERLmmdnfLEHLAHWNPAL----- 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 546 VVLDEADRMIDMG--FEPD------VQKILEHMPVSNQKPDTDEAEdpekmlanfesgkhkyRQTVmftatmppaVERLA 617
Cdd:PRK11057 143 LAVDEAHCISQWGhdFRPEyaalgqLRQRFPTLPFMALTATADDTT----------------RQDI---------VRLLG 197
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 618 rsyLRRPaVVYIGSAGKPHERVEqkvfLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGG 697
Cdd:PRK11057 198 ---LNDP-LIQISSFDRPNIRYT----LVEKFKPLDQLMRYVQEQRGKSGIIYCNSRAKVEDTAARLQSRGISAAAYHAG 269
|
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 41327771 698 KGQEQREFALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTKEDSA 774
Cdd:PRK11057 270 LDNDVRADVQEAFQRDDLQIVVATVAFGMGINKPNVRFVVHFDIPRNIESYYQETGRAGRDGLPAEAMLFYDPADMA 346
|
|
| PRK13766 |
PRK13766 |
Hef nuclease; Provisional |
650-777 |
1.99e-07 |
|
Hef nuclease; Provisional
Pssm-ID: 237496 [Multi-domain] Cd Length: 773 Bit Score: 54.88 E-value: 1.99e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 650 EKRKKLLA-ILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNA------CTLHGGKG---QEQREfALSNLKAGAKDILV 719
Cdd:PRK13766 350 EKLREIVKeQLGKNPDSRIIVFTQYRDTAEKIVDLLEKEGIKAvrfvgqASKDGDKGmsqKEQIE-ILDKFRAGEFNVLV 428
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 720 ATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRaGKSGVAITFLTKE--DSAVFY 777
Cdd:PRK13766 429 STSVAEEGLDIPSVDLVIFYEPVPSEIRSIQRKGRTGR-QEEGRVVVLIAKGtrDEAYYW 487
|
|
| SF2_C_FANCM_Hef |
cd18801 |
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M ... |
651-757 |
4.42e-07 |
|
C-terminal helicase domain of Fanconi anemia group M family helicases; Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. It is required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. FANCM and Hef are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350188 [Multi-domain] Cd Length: 143 Bit Score: 50.05 E-value: 4.42e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 651 KRKKLLAILEQGF-------DPPIIIFVNQKKGCDVLAKSLEKMGY-----------NACTLHGGKGQEQREfALSNLKA 712
Cdd:cd18801 10 KLEKLEEIVKEHFkkkqegsDTRVIIFSEFRDSAEEIVNFLSKIRPgiratrfigqaSGKSSKGMSQKEQKE-VIEQFRK 88
|
90 100 110 120
....*....|....*....|....*....|....*....|....*
gi 41327771 713 GAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGR 757
Cdd:cd18801 89 GGYNVLVATSIGEEGLDIGEVDLIICYDASPSPIRMIQRMGRTGR 133
|
|
| DEXHc_RecQ |
cd17920 |
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box ... |
410-631 |
4.54e-06 |
|
DEXH-box helicase domain of RecQ family proteins; The RecQ family of the type II DEAD box helicase superfamily is a family of highly conserved DNA repair helicases. This domain contains the ATP-binding region.
Pssm-ID: 350678 [Multi-domain] Cd Length: 200 Bit Score: 48.30 E-value: 4.54e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 410 GYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVwittLPKIdrieesdqgpyAIILAPTRELAQ-QIEEEt 488
Cdd:cd17920 9 GYDEFRPGQLEAINAVLAGRDVLVVMPTGGGKSLCYQLPALL----LDGV-----------TLVVSPLISLMQdQVDRL- 72
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 489 ikfgKPLGIRTVAVIGGISREDQ---GFRLRMG-CEIVIATPGRL-----IDVLENRYLvLSRCTYVVLDEA-------- 551
Cdd:cd17920 73 ----QQLGIRAAALNSTLSPEEKrevLLRIKNGqYKLLYVTPERLlspdfLELLQRLPE-RKRLALIVVDEAhcvsqwgh 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 552 DrmidmgFEPDVQKILEHMpvsnqkpdtdeaedpeKMLANFesgkhkyrQTVMFTATMPPAVERLARSYLR-RPAVVYIG 630
Cdd:cd17920 148 D------FRPDYLRLGRLR----------------RALPGV--------PILALTATATPEVREDILKRLGlRNPVIFRA 197
|
.
gi 41327771 631 S 631
Cdd:cd17920 198 S 198
|
|
| PRK13767 |
PRK13767 |
ATP-dependent helicase; Provisional |
411-506 |
8.29e-06 |
|
ATP-dependent helicase; Provisional
Pssm-ID: 237497 [Multi-domain] Cd Length: 876 Bit Score: 49.50 E-value: 8.29e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 411 YKEPTPIQRQAIPIGLQNRDIIGVAETGSGKT-AAFLIPllvwITTLPKIDRIEESDQGPYAIILAPTRELAQQIE---E 486
Cdd:PRK13767 30 FGTFTPPQRYAIPLIHEGKNVLISSPTGSGKTlAAFLAI----IDELFRLGREGELEDKVYCLYVSPLRALNNDIHrnlE 105
|
90 100
....*....|....*....|.
gi 41327771 487 EtikfgkPL-GIRTVAVIGGI 506
Cdd:PRK13767 106 E------PLtEIREIAKERGE 120
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
412-569 |
1.21e-05 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 46.13 E-value: 1.21e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 412 KEPTPIQRQAI-----PIGLQNRDIIGVAETGSGKT--AAFLIPLLvwiTTLPKIDRIeesdqgpyaIILAPTRELAQQI 484
Cdd:pfam04851 2 LELRPYQIEAIenlleSIKNGQKRGLIVMATGSGKTltAAKLIARL---FKKGPIKKV---------LFLVPRKDLLEQA 69
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 485 EEETIKFGKplgirTVAVIGGISREDQGFRLRMGCEIVIATPGRL--IDVLENRYLVLSRCTYVVLDEADRMIDMGFepd 562
Cdd:pfam04851 70 LEEFKKFLP-----NYVEIGEIISGDKKDESVDDNKIVVTTIQSLykALELASLELLPDFFDVIIIDEAHRSGASSY--- 141
|
....*..
gi 41327771 563 vQKILEH 569
Cdd:pfam04851 142 -RNILEY 147
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
627-765 |
1.51e-05 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 45.62 E-value: 1.51e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 627 VYIGSAGKPHERVEQKvflMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYnactLHGGKGQEQRE-- 704
Cdd:cd18795 9 VLGFNGLGIKLRVDVM---NKFDSDIIVLLKIETVSEGKPVLVFCSSRKECEKTAKDLAGIAF----HHAGLTREDRElv 81
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41327771 705 ---FALSNLKagakdILVATD--VAG-----RGIDIQDVSMVVNYDMAK-NIEDYIHRIGRTGRAG--KSGVAI 765
Cdd:cd18795 82 eelFREGLIK-----VLVATStlAAGvnlpaRTVIIKGTQRYDGKGYRElSPLEYLQMIGRAGRPGfdTRGEAI 150
|
|
| DEXHc_RIG-I |
cd17927 |
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I ... |
412-553 |
1.79e-05 |
|
DEXH-box helicase domain of DEAD-like helicase RIG-I family proteins; Members of the RIG-I family include FANCM, dicer, Hef, and the RIG-I-like receptors. Fanconi anemia group M (FANCM) protein is a DNA-dependent ATPase component of the Fanconi anemia (FA) core complex required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. Dicer ribonucleases cleave double-stranded RNA (dsRNA) precursors to generate microRNAs (miRNAs) and small interfering RNAs (siRNAs). Hef (helicase-associated endonuclease fork-structure) is involved in stalled replication fork repair. RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprises RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). The RIG-I family is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350685 [Multi-domain] Cd Length: 201 Bit Score: 46.27 E-value: 1.79e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 412 KEPTPIQRQAIPIGLQNRDIIGVAETGSGKTaafLIPLLVWITTLPKIdrieESDQGPYAIILAPTREL-AQQIEEETIK 490
Cdd:cd17927 1 FKPRNYQLELAQPALKGKNTIICLPTGSGKT---FVAVLICEHHLKKF----PAGRKGKVVFLANKVPLvEQQKEVFRKH 73
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41327771 491 FGKPlGIRTVAVIGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYLV-LSRCTYVVLDEADR 553
Cdd:cd17927 74 FERP-GYKVTGLSGDTSENVSVEQIVESSDVIIVTPQILVNDLKSGTIVsLSDFSLLVFDECHN 136
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
417-526 |
1.96e-05 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 46.58 E-value: 1.96e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 417 IQRQAIPIGLQ-NRDIIGVAETGSGKTAAF---LIPLLVWITTLPKIDRIeesdqgpyAIILAPTRELAQQIEEE-TIKF 491
Cdd:cd18023 5 IQSEVFPDLLYsDKNFVVSAPTGSGKTVLFelaILRLLKERNPLPWGNRK--------VVYIAPIKALCSEKYDDwKEKF 76
|
90 100 110
....*....|....*....|....*....|....*
gi 41327771 492 GkPLGIRTVAVIGGISREDqgFRLRMGCEIVIATP 526
Cdd:cd18023 77 G-PLGLSCAELTGDTEMDD--TFEIQDADIILTTP 108
|
|
| DEXHc_RLR |
cd18036 |
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense ... |
413-550 |
6.78e-05 |
|
DEXH-box helicase domain of RIG-I-like receptors; RIG-I-like receptors (RLRs) sense cytoplasmic viral RNA and comprise RIG-I, RLR-2/MDA5 (melanoma differentiation-associated protein 5) and RLR-3/LGP2 (laboratory of genetics and physiology 2). RIG-I-like receptors (RLRs) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350794 [Multi-domain] Cd Length: 204 Bit Score: 44.77 E-value: 6.78e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 413 EPTPIQRQAIPIGLQNRDIIGVAETGSGKT-AAFLIpllvwitTLPKIDRIEESDQGPYAIILAPTRELAQQieeETIKF 491
Cdd:cd18036 2 ELRNYQLELVLPALRGKNTIICAPTGSGKTrVAVYI-------CRHHLEKRRSAGEKGRVVVLVNKVPLVEQ---QLEKF 71
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 41327771 492 GKPL-GIRTVAVIGGISREDQGFR-LRMGCEIVIATPGRLIDVL----ENRYLVLSRCTYVVLDE 550
Cdd:cd18036 72 FKYFrKGYKVTGLSGDSSHKVSFGqIVKASDVIICTPQILINNLlsgrEEERVYLSDFSLLIFDE 136
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
416-577 |
8.95e-05 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 43.86 E-value: 8.95e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 416 PIQRQAIPIGL-QNRDIIGVAETGSGKTaaflipLLVWITTLPKIDRieesdqGPYAIILAPTRELAQQIEEETIKFgKP 494
Cdd:cd18028 4 PPQAEAVRAGLlKGENLLISIPTASGKT------LIAEMAMVNTLLE------GGKALYLVPLRALASEKYEEFKKL-EE 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 495 LGIRTVAVIGGISREDQGFRlrmGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSN 574
Cdd:cd18028 71 IGLKVGISTGDYDEDDEWLG---DYDIIVATYEKFDSLLRHSPSWLRDVGVVVVDEIHLISDEERGPTLESIVARLRRLN 147
|
...
gi 41327771 575 QKP 577
Cdd:cd18028 148 PNT 150
|
|
| Lhr |
COG1201 |
Lhr-like helicase [Replication, recombination and repair]; |
411-485 |
2.13e-04 |
|
Lhr-like helicase [Replication, recombination and repair];
Pssm-ID: 440814 [Multi-domain] Cd Length: 850 Bit Score: 45.09 E-value: 2.13e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 41327771 411 YKEPTPIQRQAIPIGLQNRDIIGVAETGSGKT-AAFLIPLLVWITTLPKIDRieesDQGPYAIILAPTRELAQQIE 485
Cdd:COG1201 22 FGAPTPPQREAWPAIAAGESTLLIAPTGSGKTlAAFLPALDELARRPRPGEL----PDGLRVLYISPLKALANDIE 93
|
|
| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
428-550 |
4.21e-04 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 41.80 E-value: 4.21e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 428 NRDIIGVAETGSGKT-AAFlipllvwittLPKIDRI-EESDQGPYAIILAPTRELAQQIEE------ETIKFGKPLGIRT 499
Cdd:cd17922 1 GRNVLIAAPTGSGKTeAAF----------LPALSSLaDEPEKGVQVLYISPLKALINDQERrleeplDEIDLEIPVAVRH 70
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|...
gi 41327771 500 vaviGGISREDQGFRLRMGCEIVIATPGRLIDVLENRYL--VLSRCTYVVLDE 550
Cdd:cd17922 71 ----GDTSQSEKAKQLKNPPGILITTPESLELLLVNKKLreLFAGLRYVVVDE 119
|
|
| DEXHc_RecG |
cd17918 |
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase ... |
413-505 |
4.88e-04 |
|
DEXH/Q-box helicase domain of DEAD-like helicase RecG family proteins; The DEAD-like helicase RecG family is part of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350676 [Multi-domain] Cd Length: 180 Bit Score: 42.02 E-value: 4.88e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 413 EPTPIQRQAIpiglqnRDIIG------------VAETGSGKTAAFLIPLLVWIttlpkidrieesDQGPYAIILAPTREL 480
Cdd:cd17918 15 SLTKDQAQAI------KDIEKdlhspepmdrllSGDVGSGKTLVALGAALLAY------------KNGKQVAILVPTEIL 76
|
90 100
....*....|....*....|....*
gi 41327771 481 AQQIEEETIKFGKPlgIRTVAVIGG 505
Cdd:cd17918 77 AHQHYEEARKFLPF--INVELVTGG 99
|
|
| SF-CC1 |
TIGR01622 |
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors ... |
80-209 |
8.16e-04 |
|
splicing factor, CC1-like family; This model represents a subfamily of RNA splicing factors including the Pad-1 protein (N. crassa), CAPER (M. musculus) and CC1.3 (H.sapiens). These proteins are characterized by an N-terminal arginine-rich, low complexity domain followed by three (or in the case of 4 H. sapiens paralogs, two) RNA recognition domains (rrm: pfam00706). These splicing factors are closely related to the U2AF splicing factor family (TIGR01642). A homologous gene from Plasmodium falciparum was identified in the course of the analysis of that genome at TIGR and was included in the seed.
Pssm-ID: 273721 [Multi-domain] Cd Length: 494 Bit Score: 42.98 E-value: 8.16e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 80 DKERDRNK-----KDRDRDKDGHR-RDKDRKRSSlspGRGKDFKSRKDRDSKKDEEDEHGDKKPKAQPLSleellakkka 153
Cdd:TIGR01622 6 ERERLRDSssagdRDRRRDKGRERsRDRSRDRER---SRSRRRDRHRDRDYYRGRERRSRSRRPNRRYRP---------- 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 41327771 154 eeeaeakpkflskaereaEALKRRQQEVEERQRMLEEERKKRKQFQDLGRKMLEDP 209
Cdd:TIGR01622 73 ------------------REKRRRRGDSYRRRRDDRRSRREKPRARDGTPEPLTED 110
|
|
| DEXHc_Hef |
cd18035 |
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs ... |
417-553 |
1.25e-03 |
|
DEXH-box helicase domain of Hef; Hef (helicase-associated endonuclease fork-structure) belongs to the XPF/MUS81/FANCM family of endonucleases and is involved in stalled replication fork repair. All archaea encode a protein of the XPF/MUS81/FANCM family of endonucleases. It exists in two forms: a long form, referred as Hef which consists of an N-terminal helicase fused to a C-terminal nuclease and is specific to euryarchaea and a short form, referred as XPF which lacks the helicase domain and is specific to crenarchaea and thaumarchaea. Hef has the unique feature of having both active helicase and nuclease domains. This domain configuration is highly similar with the human FANCM, a possible ortholog of archaeal Hef proteins. Hef is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350793 [Multi-domain] Cd Length: 181 Bit Score: 40.58 E-value: 1.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 417 IQRQAIPIGLQNRDIIGVAETGSGKTaafLIPLLVWITTLPKidrieesdQGPYAIILAPTRELAQQiEEETIKFGKPLG 496
Cdd:cd18035 5 LYQVLIAAVALNGNTLIVLPTGLGKT---IIAILVAADRLTK--------KGGKVLILAPSRPLVEQ-HAENLKRVLNIP 72
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*...
gi 41327771 497 IRTVAVIGGISREDQGFRLRmGCEIVIATPGRL-IDVLENRYlVLSRCTYVVLDEADR 553
Cdd:cd18035 73 DKITSLTGEVKPEERAERWD-ASKIIVATPQVIeNDLLAGRI-TLDDVSLLIFDEAHH 128
|
|
| SF2_C_XPB |
cd18789 |
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex ... |
624-780 |
3.93e-03 |
|
C-terminal helicase domain of XPB-like helicases; TFIIH basal transcription factor complex helicase XPB (xeroderma pigmentosum type B) subunit (also known as DNA excision repair protein ERCC-3 or TFIIH 89 kDa subunit) is the ATP-dependent 3'-5' DNA helicase component of the core-TFIIH basal transcription factor, involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. XPB is a DEAD-like helicase belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350176 [Multi-domain] Cd Length: 153 Bit Score: 38.77 E-value: 3.93e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 624 PAVVYIGSAGKPHERVEQKVFLMSES--EKRKKLLAILEQGfdPPIIIFVNQKKGCDVLAKSLekmgyNACTLHGGKGQE 701
Cdd:cd18789 9 TPEFYREYLGLGAHRKRRLLAAMNPNklRALEELLKRHEQG--DKIIVFTDNVEALYRYAKRL-----LKPFITGETPQS 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 702 QREFALSNLKAGAKDILVATDVAGRGIDIQD--VSMVVNYDMAKNIEdYIHRIGRTGRAGKSGvaitfltkEDSAVFYEL 779
Cdd:cd18789 82 EREEILQNFREGEYNTLVVSKVGDEGIDLPEanVAIQISGHGGSRRQ-EAQRLGRILRPKKGG--------GKNAFFYSL 152
|
.
gi 41327771 780 K 780
Cdd:cd18789 153 V 153
|
|
| DEXHc_DDX60 |
cd18025 |
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an ... |
418-550 |
4.65e-03 |
|
DEXH-box helicase domain of DEAD box protein 60; DEAD box protein 60 (DDX60) is an IFN-inducible cytoplasmic helicase that plays a role in RIG-I-mediated type I interferon (IFN) nuclease-mediated viral RNA degradation. DDX60 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350783 [Multi-domain] Cd Length: 192 Bit Score: 39.27 E-value: 4.65e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 418 QRQAIPIGLQNRDIIGVAETGSGKTaafliplLVWITTLPKIDRieESDQGpYAIILAPTRELAQQIEEETI-KFGKPLG 496
Cdd:cd18025 6 QRELLDIVDRRESALIVAPTSSGKT-------FISYYCMEKVLR--ESDDG-VVVYVAPTKALVNQVVAEVYaRFSKKYP 75
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 41327771 497 IRTVAVIGGISREdqgFRLR--MGCEIVIATPgrliDVLEnrYLVLS--------RCTYVVLDE 550
Cdd:cd18025 76 PSGKSLWGVFTRD---YRHNnpMNCQVLITVP----ECLE--ILLLSphnaswvpRIKYVIFDE 130
|
|
| PTZ00121 |
PTZ00121 |
MAEBL; Provisional |
4-351 |
9.37e-03 |
|
MAEBL; Provisional
Pssm-ID: 173412 [Multi-domain] Cd Length: 2084 Bit Score: 39.74 E-value: 9.37e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 4 ELADKKDRDASPSKEERKRSRTPDRERDRDRDRKSSPSKDRKRHRSRDRRRGGSRSRSRSRSksAERERRHKERERDKER 83
Cdd:PTZ00121 1325 EEAKKKADAAKKKAEEAKKAAEAAKAEAEAAADEAEAAEEKAEAAEKKKEEAKKKADAAKKK--AEEKKKADEAKKKAEE 1402
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 84 DRNKKDRDRDKDGHRRDKDRKRSSLSPGRGKDFKSRKDRDSKKDEEdehgdKKPKAQPLSLEELLAKKKAEEEAEAKPKF 163
Cdd:PTZ00121 1403 DKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEAKKADE-----AKKKAEEAKKAEEAKKKAEEAKKADEAKK 1477
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 164 LSKAEREAEALKRRqqeVEERQRMLEEERKKRKQfqdlgRKMLEDPQERERRERRERMERETNGNEDEEGRQKirEEKDK 243
Cdd:PTZ00121 1478 KAEEAKKADEAKKK---AEEAKKKADEAKKAAEA-----KKKADEAKKAEEAKKADEAKKAEEAKKADEAKKA--EEKKK 1547
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 41327771 244 SKELHAIKE-RYLGGIKKRRRTRHLNDRKFVFEWDASEDTSIdynplykERHQVQLLGRGFiagIDLKQQKREQSRFYGD 322
Cdd:PTZ00121 1548 ADELKKAEElKKAEEKKKAEEAKKAEEDKNMALRKAEEAKKA-------EEARIEEVMKLY---EEEKKMKAEEAKKAEE 1617
|
330 340
....*....|....*....|....*....
gi 41327771 323 LMEKRRTLEEKEQEEARLRKLRKKEAKQR 351
Cdd:PTZ00121 1618 AKIKAEELKKAEEEKKKVEQLKKKEAEEK 1646
|
|
| |
