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Conserved domains on  [gi|4757702|ref|NP_004837|]
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eukaryotic translation initiation factor 4E type 2 isoform A [Homo sapiens]

Protein Classification

eukaryotic translation initiation factor 4E( domain architecture ID 10483299)

eukaryotic translation initiation factor 4E (EIF4E) recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of secondary structures of mRNAs

CATH:  3.30.760.10
PubMed:  30636602|31074051
SCOP:  4001578

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
IF4E pfam01652
Eukaryotic initiation factor 4E;
55-214 2.27e-88

Eukaryotic initiation factor 4E;


:

Pssm-ID: 460281  Cd Length: 158  Bit Score: 258.22  E-value: 2.27e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702     55 PLQYNYTFWYSRRtpgrPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGK 134
Cdd:pfam01652   1 PLQNTWTLWYDTK----PDKSKSYEDNLKKIGTFDTVEDFWSLYNHIKPPSELPPGSDYHLFKEGIKPMWEDPANKNGGK 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702    135 WIIRLRK-GLASRCWENLILAMLGEQF-MVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIM 212
Cdd:pfam01652  77 WIIRLKKkGLLDRLWEDLLLALIGEQFdEDSDEICGAVVSVRKKEDKISIWTRDASDEEAVLKIGKKLKEVLGLPPNTKI 156

                  ..
gi 4757702    213 EY 214
Cdd:pfam01652 157 EY 158
 
Name Accession Description Interval E-value
IF4E pfam01652
Eukaryotic initiation factor 4E;
55-214 2.27e-88

Eukaryotic initiation factor 4E;


Pssm-ID: 460281  Cd Length: 158  Bit Score: 258.22  E-value: 2.27e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702     55 PLQYNYTFWYSRRtpgrPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGK 134
Cdd:pfam01652   1 PLQNTWTLWYDTK----PDKSKSYEDNLKKIGTFDTVEDFWSLYNHIKPPSELPPGSDYHLFKEGIKPMWEDPANKNGGK 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702    135 WIIRLRK-GLASRCWENLILAMLGEQF-MVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIM 212
Cdd:pfam01652  77 WIIRLKKkGLLDRLWEDLLLALIGEQFdEDSDEICGAVVSVRKKEDKISIWTRDASDEEAVLKIGKKLKEVLGLPPNTKI 156

                  ..
gi 4757702    213 EY 214
Cdd:pfam01652 157 EY 158
CDC33 COG5053
Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];
54-221 4.53e-35

Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227386  Cd Length: 217  Bit Score: 124.62  E-value: 4.53e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702   54 HPLQYNYTFWY-SRRTPGrptsSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNG 132
Cdd:COG5053  37 HPLAFHWTLWFlKPPEDG----LESWSDLLKSIITFETVEEFWYILHNISDASRLPRKSDYNVFREGIRPEWEDEANMNG 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702  133 GKWIIRLRKGLASRC---WENLILAMLGEQF-MVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPP 208
Cdd:COG5053 113 GKWSFQLKGKGCDRLdelWLRTLLAAIGETLdPTGSEIGGVVGNMRKGFYKLAIWTRNCNNKDVLGAIGNEFKQVLELSD 192
                       170
                ....*....|...
gi 4757702  209 NTIMEYKTHTDSI 221
Cdd:COG5053 193 VETLEYKAHESSK 205
PTZ00040 PTZ00040
translation initiation factor E4; Provisional
55-190 3.79e-18

translation initiation factor E4; Provisional


Pssm-ID: 240238  Cd Length: 233  Bit Score: 80.24  E-value: 3.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702    55 PLQYNYTFWySRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGH-------SD--FH------LFKEG 119
Cdd:PTZ00040  39 PLSYKWVIW-EQVVKETIRKSNDYKDYTKPLASFDSVQKFWQLWFNIPQPSELLTGkrmiresSDgsEHvvdavmIFKDG 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702   120 IKPMWEDDANKNGGKWIIRLR-----KGLASRCWENLILAMLGEQFMVGEEICGA----VVSVRFQEDIISIWNKTASDQ 190
Cdd:PTZ00040 118 IQPMWEDPMNATGGHFEYRFWptdvsPGQIDEYWNNLVLALIGSSLEHSSLINGIrlvdKLSGRFGVIRIEIWFTNLGDQ 197
 
Name Accession Description Interval E-value
IF4E pfam01652
Eukaryotic initiation factor 4E;
55-214 2.27e-88

Eukaryotic initiation factor 4E;


Pssm-ID: 460281  Cd Length: 158  Bit Score: 258.22  E-value: 2.27e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702     55 PLQYNYTFWYSRRtpgrPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNGGK 134
Cdd:pfam01652   1 PLQNTWTLWYDTK----PDKSKSYEDNLKKIGTFDTVEDFWSLYNHIKPPSELPPGSDYHLFKEGIKPMWEDPANKNGGK 76
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702    135 WIIRLRK-GLASRCWENLILAMLGEQF-MVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPPNTIM 212
Cdd:pfam01652  77 WIIRLKKkGLLDRLWEDLLLALIGEQFdEDSDEICGAVVSVRKKEDKISIWTRDASDEEAVLKIGKKLKEVLGLPPNTKI 156

                  ..
gi 4757702    213 EY 214
Cdd:pfam01652 157 EY 158
CDC33 COG5053
Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];
54-221 4.53e-35

Translation initiation factor 4E (eIF-4E) [Translation, ribosomal structure and biogenesis];


Pssm-ID: 227386  Cd Length: 217  Bit Score: 124.62  E-value: 4.53e-35
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702   54 HPLQYNYTFWY-SRRTPGrptsSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGHSDFHLFKEGIKPMWEDDANKNG 132
Cdd:COG5053  37 HPLAFHWTLWFlKPPEDG----LESWSDLLKSIITFETVEEFWYILHNISDASRLPRKSDYNVFREGIRPEWEDEANMNG 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702  133 GKWIIRLRKGLASRC---WENLILAMLGEQF-MVGEEICGAVVSVRFQEDIISIWNKTASDQATTARIRDTLRRVLNLPP 208
Cdd:COG5053 113 GKWSFQLKGKGCDRLdelWLRTLLAAIGETLdPTGSEIGGVVGNMRKGFYKLAIWTRNCNNKDVLGAIGNEFKQVLELSD 192
                       170
                ....*....|...
gi 4757702  209 NTIMEYKTHTDSI 221
Cdd:COG5053 193 VETLEYKAHESSK 205
PTZ00040 PTZ00040
translation initiation factor E4; Provisional
55-190 3.79e-18

translation initiation factor E4; Provisional


Pssm-ID: 240238  Cd Length: 233  Bit Score: 80.24  E-value: 3.79e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702    55 PLQYNYTFWySRRTPGRPTSSQSYEQNIKQIGTFASVEQFWRFYSHMVRPGDLTGH-------SD--FH------LFKEG 119
Cdd:PTZ00040  39 PLSYKWVIW-EQVVKETIRKSNDYKDYTKPLASFDSVQKFWQLWFNIPQPSELLTGkrmiresSDgsEHvvdavmIFKDG 117
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4757702   120 IKPMWEDDANKNGGKWIIRLR-----KGLASRCWENLILAMLGEQFMVGEEICGA----VVSVRFQEDIISIWNKTASDQ 190
Cdd:PTZ00040 118 IQPMWEDPMNATGGHFEYRFWptdvsPGQIDEYWNNLVLALIGSSLEHSSLINGIrlvdKLSGRFGVIRIEIWFTNLGDQ 197
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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