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Conserved domains on  [gi|48675811|ref|NP_004898|]
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immediate early response gene 2 protein [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
IER super family cl25623
Immediate early response protein (IER); This family consists of several eukaryotic immediate ...
 1-116 1.70e-14

Immediate early response protein (IER); This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it play an important role in mediating the cellular response to mitogenic signals. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals.


The actual alignment was detected with superfamily member pfam05760:

Pssm-ID: 461732  Cd Length: 310  Bit Score: 70.70  E-value: 1.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675811     1 MEVQKEAQRIMTLSVWKMYHSRMQRGGLRLHRSLQLSLVMRSARELYLSAKVealePEVSL--PAALPSDPRLHPPrEAE 78
Cdd:pfam05760   1 MECAVDAQSLISISLRKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYLSEKY----AELYRmqQYEEVAPPPEQQE-YMA 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 48675811    79 STAETATPdgeHPFPEPMDTQEAPTA----------EETSACCAPRPA 116
Cdd:pfam05760  76 VCGEIPEL---NPLPLAEDVGDEGPAddvycngtglESGEWHCGPRQA 120
 
Name Accession Description Interval E-value
IER pfam05760
Immediate early response protein (IER); This family consists of several eukaryotic immediate ...
 1-116 1.70e-14

Immediate early response protein (IER); This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it play an important role in mediating the cellular response to mitogenic signals. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals.


Pssm-ID: 461732  Cd Length: 310  Bit Score: 70.70  E-value: 1.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675811     1 MEVQKEAQRIMTLSVWKMYHSRMQRGGLRLHRSLQLSLVMRSARELYLSAKVealePEVSL--PAALPSDPRLHPPrEAE 78
Cdd:pfam05760   1 MECAVDAQSLISISLRKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYLSEKY----AELYRmqQYEEVAPPPEQQE-YMA 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 48675811    79 STAETATPdgeHPFPEPMDTQEAPTA----------EETSACCAPRPA 116
Cdd:pfam05760  76 VCGEIPEL---NPLPLAEDVGDEGPAddvycngtglESGEWHCGPRQA 120
 
Name Accession Description Interval E-value
IER pfam05760
Immediate early response protein (IER); This family consists of several eukaryotic immediate ...
 1-116 1.70e-14

Immediate early response protein (IER); This family consists of several eukaryotic immediate early response (IER) 2 and 5 proteins. The role of IER5 is unclear although it play an important role in mediating the cellular response to mitogenic signals. Again, little is known about the function of IER2 although it is thought to play a role in mediating the cellular responses to a variety of extracellular signals.


Pssm-ID: 461732  Cd Length: 310  Bit Score: 70.70  E-value: 1.70e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 48675811     1 MEVQKEAQRIMTLSVWKMYHSRMQRGGLRLHRSLQLSLVMRSARELYLSAKVealePEVSL--PAALPSDPRLHPPrEAE 78
Cdd:pfam05760   1 MECAVDAQSLISISLRKIHNSRTQRGGIKLHKNLLVSYVLRNARQVYLSEKY----AELYRmqQYEEVAPPPEQQE-YMA 75

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 48675811    79 STAETATPdgeHPFPEPMDTQEAPTA----------EETSACCAPRPA 116
Cdd:pfam05760  76 VCGEIPEL---NPLPLAEDVGDEGPAddvycngtglESGEWHCGPRQA 120
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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