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Conserved domains on  [gi|4827012|ref|NP_005062|]
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excitatory amino acid transporter 4 isoform 2 [Homo sapiens]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10003465)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
54-533 4.79e-121

Na+/H+-dicarboxylate symporter [Energy production and conversion];


:

Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 362.89  E-value: 4.79e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   54 RRNAFILLTVSAVVIGVSLAFALRPYQLTYrqikyFSFPGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAA 132
Cdd:COG1301   1 FKLSLTLQILIALVLGILLGLLLPELVAAV-----LKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  133 VYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETiPTADAFMDLIRNMFPPNLVEAcfkqfktqystrvvtrtmv 212
Cdd:COG1301  76 LYFLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEA-AEAPSLLDFLLNIIPSNIFEA------------------- 135
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  213 rtengsepgasmpppfsvengtsFLENvtralgtlqemlsfeetvpvpgsangiNALGLVVFSVAFGLVIGGMKHKGRVL 292
Cdd:COG1301 136 -----------------------FAEG---------------------------NMLQIIFFAILFGIALAALGEKGKPL 165
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  293 RDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMeDMAVLGgQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFP 372
Cdd:COG1301 166 LDFFESLSEVMFKIVGWVMKLAPIGVFALIAATVAKY-GLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLK 243
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  373 FIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQIT 452
Cdd:COG1301 244 FLRAIRPALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQL 323
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  453 TISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHlSQRELELQEA 532
Cdd:COG1301 324 TIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK-WEGELDREKL 402

                .
gi 4827012  533 E 533
Cdd:COG1301 403 N 403
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
54-533 4.79e-121

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 362.89  E-value: 4.79e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   54 RRNAFILLTVSAVVIGVSLAFALRPYQLTYrqikyFSFPGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAA 132
Cdd:COG1301   1 FKLSLTLQILIALVLGILLGLLLPELVAAV-----LKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  133 VYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETiPTADAFMDLIRNMFPPNLVEAcfkqfktqystrvvtrtmv 212
Cdd:COG1301  76 LYFLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEA-AEAPSLLDFLLNIIPSNIFEA------------------- 135
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  213 rtengsepgasmpppfsvengtsFLENvtralgtlqemlsfeetvpvpgsangiNALGLVVFSVAFGLVIGGMKHKGRVL 292
Cdd:COG1301 136 -----------------------FAEG---------------------------NMLQIIFFAILFGIALAALGEKGKPL 165
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  293 RDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMeDMAVLGgQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFP 372
Cdd:COG1301 166 LDFFESLSEVMFKIVGWVMKLAPIGVFALIAATVAKY-GLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLK 243
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  373 FIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQIT 452
Cdd:COG1301 244 FLRAIRPALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQL 323
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  453 TISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHlSQRELELQEA 532
Cdd:COG1301 324 TIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK-WEGELDREKL 402

                .
gi 4827012  533 E 533
Cdd:COG1301 403 N 403
SDF pfam00375
Sodium:dicarboxylate symporter family;
58-522 9.85e-114

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 343.35  E-value: 9.85e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012     58 FILLTVSAVVIGVSLAFALRPYqltyrqIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAAVYYM 136
Cdd:pfam00375   1 LLLQILIALVLGILIGLFFPEL------AAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012    137 VTTIIAVFIGILMVTIIHPGKGSKeGLHREGRIETIPTADAFMDLIRNMFPPNLVEACFKQfktqystrvvtrtmvrten 216
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLA-LIAASLKEAKAAEAPSLLDFILNIIPSNIFEALAEG------------------- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012    217 gsepgasmpppfsvengtsflenvtralgtlqemlsfeetvpvpgsangiNALGLVVFSVAFGLVIGGMKHKGRVLRDFF 296
Cdd:pfam00375 135 --------------------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFI 164
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012    297 DSLNEAIMRLVGIIIWYAPVGILFLIAGKILEmEDMAVLGgQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFPFIGG 376
Cdd:pfam00375 165 ESLQEVMMKVIGWVMKLAPIGVFALIANTVGT-YGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKK 242
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012    377 MLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISI 456
Cdd:pfam00375 243 MLPALLTAFSTASSAATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVL 322
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4827012    457 TATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHL 522
Cdd:pfam00375 323 TATLASIGAAGVPGGGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
63-519 3.41e-40

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 150.97  E-value: 3.41e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012    63 VSAVVIGVSLAFALRPYQLTYRQIkyfsfpGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAAVYYMVTTII 141
Cdd:PRK13027  13 VIALVLGVALGAFFPHFAESLKPL------GDGFIKLIKMLIGPIVFCVVVSGIAGAgDLKKVGRVGLKAVIYFEVMTTI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   142 AVFIGILMVTIIHPGKGSKEGLHregrieTIPTADAfmdlirnmfppnlveacfkqfktqystrvvtrtmvrtengsepg 221
Cdd:PRK13027  87 ALVIGLVLAYLTGPGVGMNIDLR------SLDAASL-------------------------------------------- 116
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   222 asmpppfsvengTSFLENVTRALGTLQEMLSFEETVPVPGSANGiNALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNE 301
Cdd:PRK13027 117 ------------AGYAKNAQSLKGTAGFLLKLIPTTAVDAFAKG-DILQVLLFSVLFGSALSLLGERAKRVNRLIDELSH 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   302 AIMRLVGIIIWYAPVGILFLIA---GKiLEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVthrnpFPFIGGML 378
Cdd:PRK13027 184 VLFRIMGFIIKLAPLGVLGAIAfttGK-YGVGSLKQLGMLVAVFYLTCFVFVVVVLGAVMRLAGFSV-----FKLIRYLR 257
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   379 QALITAMGTSSSSATLPITFRCLEEgLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITA 458
Cdd:PRK13027 258 EELLIVLGTASSDAVLPQVMRKLEH-MGIKDSTVGLVIPTGYSFNLDGFSIYLTLAAVFIAQATNTPLSMHDLITILLVS 336
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4827012   459 TAASVGAAGIPQAGLVTMVIVLTSVG-LPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVI 519
Cdd:PRK13027 337 LVTSKGAHGIPGSAIVILAATLSAIPaIPVLGLVLILPVDWFMGIARALTNLIGNCVATVVV 398
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
54-533 4.79e-121

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 362.89  E-value: 4.79e-121
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   54 RRNAFILLTVSAVVIGVSLAFALRPYQLTYrqikyFSFPGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAA 132
Cdd:COG1301   1 FKLSLTLQILIALVLGILLGLLLPELVAAV-----LKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  133 VYYMVTTIIAVFIGILMVTIIHPGKGSKEGLHREGRIETiPTADAFMDLIRNMFPPNLVEAcfkqfktqystrvvtrtmv 212
Cdd:COG1301  76 LYFLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEA-AEAPSLLDFLLNIIPSNIFEA------------------- 135
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  213 rtengsepgasmpppfsvengtsFLENvtralgtlqemlsfeetvpvpgsangiNALGLVVFSVAFGLVIGGMKHKGRVL 292
Cdd:COG1301 136 -----------------------FAEG---------------------------NMLQIIFFAILFGIALAALGEKGKPL 165
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  293 RDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMeDMAVLGgQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFP 372
Cdd:COG1301 166 LDFFESLSEVMFKIVGWVMKLAPIGVFALIAATVAKY-GLDALG-SLGKLVLTVYLALLLHLFVVLPLILRLLTGLSPLK 243
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  373 FIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQIT 452
Cdd:COG1301 244 FLRAIRPALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAYGIDLSLGQQL 323
                       410       420       430       440       450       460       470       480
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  453 TISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHlSQRELELQEA 532
Cdd:COG1301 324 TIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK-WEGELDREKL 402

                .
gi 4827012  533 E 533
Cdd:COG1301 403 N 403
SDF pfam00375
Sodium:dicarboxylate symporter family;
58-522 9.85e-114

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 343.35  E-value: 9.85e-114
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012     58 FILLTVSAVVIGVSLAFALRPYqltyrqIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAAVYYM 136
Cdd:pfam00375   1 LLLQILIALVLGILIGLFFPEL------AAWLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012    137 VTTIIAVFIGILMVTIIHPGKGSKeGLHREGRIETIPTADAFMDLIRNMFPPNLVEACFKQfktqystrvvtrtmvrten 216
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLA-LIAASLKEAKAAEAPSLLDFILNIIPSNIFEALAEG------------------- 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012    217 gsepgasmpppfsvengtsflenvtralgtlqemlsfeetvpvpgsangiNALGLVVFSVAFGLVIGGMKHKGRVLRDFF 296
Cdd:pfam00375 135 --------------------------------------------------NVLAVIVFAILFGIALAALGEKGEPLLNFI 164
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012    297 DSLNEAIMRLVGIIIWYAPVGILFLIAGKILEmEDMAVLGgQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRNPFPFIGG 376
Cdd:pfam00375 165 ESLQEVMMKVIGWVMKLAPIGVFALIANTVGT-YGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFLGKVNPFKFLKK 242
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012    377 MLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISI 456
Cdd:pfam00375 243 MLPALLTAFSTASSAATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVDLSFGQQLTLVL 322
                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4827012    457 TATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIEHL 522
Cdd:pfam00375 323 TATLASIGAAGVPGGGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
63-519 3.41e-40

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 150.97  E-value: 3.41e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012    63 VSAVVIGVSLAFALRPYQLTYRQIkyfsfpGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAAVYYMVTTII 141
Cdd:PRK13027  13 VIALVLGVALGAFFPHFAESLKPL------GDGFIKLIKMLIGPIVFCVVVSGIAGAgDLKKVGRVGLKAVIYFEVMTTI 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   142 AVFIGILMVTIIHPGKGSKEGLHregrieTIPTADAfmdlirnmfppnlveacfkqfktqystrvvtrtmvrtengsepg 221
Cdd:PRK13027  87 ALVIGLVLAYLTGPGVGMNIDLR------SLDAASL-------------------------------------------- 116
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   222 asmpppfsvengTSFLENVTRALGTLQEMLSFEETVPVPGSANGiNALGLVVFSVAFGLVIGGMKHKGRVLRDFFDSLNE 301
Cdd:PRK13027 117 ------------AGYAKNAQSLKGTAGFLLKLIPTTAVDAFAKG-DILQVLLFSVLFGSALSLLGERAKRVNRLIDELSH 183
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   302 AIMRLVGIIIWYAPVGILFLIA---GKiLEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFLVthrnpFPFIGGML 378
Cdd:PRK13027 184 VLFRIMGFIIKLAPLGVLGAIAfttGK-YGVGSLKQLGMLVAVFYLTCFVFVVVVLGAVMRLAGFSV-----FKLIRYLR 257
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   379 QALITAMGTSSSSATLPITFRCLEEgLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTISITA 458
Cdd:PRK13027 258 EELLIVLGTASSDAVLPQVMRKLEH-MGIKDSTVGLVIPTGYSFNLDGFSIYLTLAAVFIAQATNTPLSMHDLITILLVS 336
                        410       420       430       440       450       460
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 4827012   459 TAASVGAAGIPQAGLVTMVIVLTSVG-LPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVI 519
Cdd:PRK13027 337 LVTSKGAHGIPGSAIVILAATLSAIPaIPVLGLVLILPVDWFMGIARALTNLIGNCVATVVV 398
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
65-519 6.65e-39

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 147.99  E-value: 6.65e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012    65 AVVIGVSLAFALRpYQLTYRQ---IKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAAVYYMVTTI 140
Cdd:PRK11283  15 ALVLGILLGAYLH-YHSDSRDwlvSNLLSPAGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAKTIIYFEVITT 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   141 IAVFIGILMVTIIHPGKGSKEGL--------HREGRIETIPTADAFMDLIRNMFPPNLVeacfkqfktqystrvvtrtmv 212
Cdd:PRK11283  94 VAIILGITLANVFQPGAGIDMSQlatvdiskYQSTTEEVQSHSHGLMGTILSLIPTNIF--------------------- 152
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   213 rtengsepgASMpppfsvengtsflenvtrALGtlqEMLsfeetvPVpgsanginalglVVFSVAFGLVIGGMKHKGRV- 291
Cdd:PRK11283 153 ---------ASM------------------AKG---EML------PI------------IFFSVLFGLGLSSLPATHREp 184
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   292 LRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLggQLGMYTLTVIVGLFLHAGIVLPLIYFLVTHRnPF 371
Cdd:PRK11283 185 LVTVFRSVSETMFKVTHMVMRYAPVGVFALIAVTVANFGFASLW--PLAKLVLLVYFAILFFALVVLGIVARLCGLS-IW 261
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   372 PFIGGMLQALITAMGTSSSSATLPitfRCLE--EGLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLG 449
Cdd:PRK11283 262 ILIRILKDELILAYSTASSETVLP---RIIEkmEAYGAPKSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQLYGIDLSIW 338
                        410       420       430       440       450       460       470
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   450 QITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVI 519
Cdd:PRK11283 339 QEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNALAVLVI 408
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
63-535 3.00e-38

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 145.82  E-value: 3.00e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012    63 VSAVVIGVSLAFAlrpYQLTYRQIKYFsfpGELLMRMLQMLVLPLIVSSLVTGMASL-DNKATGRMGMRAAVYYMVTTII 141
Cdd:PRK01663  14 LVAIIIGILLGHF---YPELGAQMKPL---GDGFIKLIKMIIAPIIFCTVVTGIAGMgDMKKVGRVGGKALLYFEIVSTI 87
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   142 AVFIGILMVTIIHPGKGskeglhregrietiptadafmdliRNMFPPNLVEACFKQFktqystrvvtrtmvrTENGSEPG 221
Cdd:PRK01663  88 ALIIGLIVVNVVQPGAG------------------------MNIDPATLDAKAVAQY---------------AAQAHEQG 128
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   222 AsmpppfsvengTSFLENVtralgtlqemlsfeetvpVPGS-----ANGiNALGLVVFSVAFGLVIGGMKHKGRVLRDFF 296
Cdd:PRK01663 129 T-----------VDFLMDI------------------IPTTvvgafASG-DILQVLLFAVLFGFALARLGEKGKPVFDFI 178
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   297 DSLNEAIMRLVGIIIWYAPVGILFLIAGKI--LEMEDMAVLGGQLGMYTLTVIVGLFLHAGIVLPLIYFlvthrNPFPFI 374
Cdd:PRK01663 179 ESLSHVLFGIVNMIMKLAPIGAFGAMAFTIgkYGVGSLVQLGQLIGCFYITCILFVFVVLGAIARLTGF-----SIFKFI 253
                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   375 GGMLQALITAMGTSSSSATLPITFRCLEEgLGVDRRITRFVLPVGATVNMDGTALYEALAAIFIAQVNNYELNLGQITTI 454
Cdd:PRK01663 254 RYIKEELLIVLGTSSSESALPRMMEKMEK-LGCKKSVVGLVIPTGYSFNLDGTSIYLTMAAVFIAQATNTPLSIGHQITL 332
                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   455 SITATAASVGAAGIPQAGLVTMVIVLTSVG-LPTEDITLIIAVDWFLDRLRTMTNVLGDSIGAAVIehlSQRELELQEAE 533
Cdd:PRK01663 333 LAVLLLTSKGAAGVTGSGFIVLAATLSAVPhIPVAGLALILGIDRFMSEARALTNLIGNGVATVVV---AKWEKELDREK 409

                 ..
gi 4827012   534 LT 535
Cdd:PRK01663 410 LD 411
TcyP COG1823
L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and ...
64-519 1.67e-18

L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and metabolism];


Pssm-ID: 441428  Cd Length: 463  Bit Score: 88.34  E-value: 1.67e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   64 SAVVIGVSLAFALrpyQLTY--------RQIKYFSFPGELLMRMLQMLVLPLIVSSLVTGMASLDN-KATGRMGMRAAVY 134
Cdd:COG1823  36 TGLGLGILFGLIL---QLIYgagspvikQSIDWFNIVGNGYVRLLQMIVMPLVFVSILSAITKLKNaSSLGKISGLIIGI 112
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  135 YMVTTIIAVFIGILMVTIIHPgkgSKEGLHrEGRIEtiptadafmdlirnmfppnlveacfkqfktqystrvvtrtmvrT 214
Cdd:COG1823 113 LLGTTAIAALVGILVALLFGL---TAEGLT-QGAAE-------------------------------------------T 145
                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  215 ENGSEpgasmpppfsVENGTSFLENVTRAlgtlQEMLSFEETVP---VPGsANGINALGLVVFSVAFGLVIGGMKHK--- 288
Cdd:COG1823 146 ARGEA----------LEERLGEVEDLSLP----QQILSFIPTNPfadLTG-ARPTSTIAVVIFAAFLGIAALGLRRKkpe 210
                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  289 -GRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAgKIL---EMEDMAVLGGQLGMYTLTVIVGLFLHagivlpLIYFL 364
Cdd:COG1823 211 qAETFLKGIDALQAIVMRLVRLVLRLTPYGVLALMT-KVVatsDFADILNLGKFVVASYVALIIMFIVH------LLLLA 283
                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  365 VTHRNPFPFIGGMLQALITAMGTSSSSATLPITFRCLEEGLGVDRRITRFVLPVGATVNMDGTA-LYEALAAIFIA-QVN 442
Cdd:COG1823 284 LAGLNPLTYFKKVWPVLTFAFTSRSSAGTIPLNIETQTKRLGVPEGIANFAASFGATIGQNGCAgIYPAMLAVMIApTVG 363
                       410       420       430       440       450       460       470
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 4827012  443 NYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFLDRLRTMTNVlGDSIGAAVI 519
Cdd:COG1823 364 INPLDPSFILTLIAVVTISSFGVAGVGGGATFAALIVLSAMGLPVALAGLLISIEPLIDMGRTALNV-SGSMTAGTV 439
PRK13628 PRK13628
serine/threonine transporter SstT; Provisional
263-468 9.83e-18

serine/threonine transporter SstT; Provisional


Pssm-ID: 184190 [Multi-domain]  Cd Length: 402  Bit Score: 85.30  E-value: 9.83e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   263 ANGINAL------GLVVFSVAFGLvigGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLG 336
Cdd:PRK13628 136 DNPINALlnanyiGILAWAIGLGL---ALRHASDTTKNVVNDLSEAVSQIVKWVIRFAPIGIFGLVASTLAETGFSALAG 212
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   337 -GQLgmytLTVIVG-LFLHAGIVLPLIYFLVTHRNPFPFIggmLQAL----ITAMGTSSSSATLPITFRcLEEGLGVDRR 410
Cdd:PRK13628 213 yAQL----LAVLVGcMLFVALVVNPLIVFWKIRRNPYPLV---FTCLresgVTAFFTRSSAANIPVNMA-LCEKLGLDED 284
                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 4827012   411 ITRFVLPVGATVNMDGtalyealAAIFI-----AQVN--NYELNLGQITTISITATAASVGAAGI 468
Cdd:PRK13628 285 TYSVSIPLGATINMAG-------AAITItvltlAAVHtlGIPVDLPTALLLSVVAAISACGASGV 342
SstT COG3633
Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];
263-469 1.46e-17

Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];


Pssm-ID: 442850  Cd Length: 406  Bit Score: 84.84  E-value: 1.46e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  263 ANGINAL------GLVVFSVAFGLvigGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVLG 336
Cdd:COG3633 135 DNPVNALananyiGILAWAIGLGL---ALRHASDTTKTVLSDLSDAVSKIVRWVIRFAPLGIFGLVASTVATTGFSALLG 211
                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012  337 -GQLgmytLTVIVG-LFLHAGIVLPLIYFLVTHRNPFPFIggmLQAL----ITAMGTSSSSATLPITFRcLEEGLGVDRR 410
Cdd:COG3633 212 yAHL----LAVLVGcMLFVALVVNPLIVFLKIRRNPYPLV---FTCLresgITAFFTRSSAANIPVNMA-LCEKLGLDED 283
                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 4827012  411 ITRFVLPVGATVNMDGtalyealAAIFI-----AQVN--NYELNLGQITTISITATAASVGAAGIP 469
Cdd:COG3633 284 TYSVSIPLGATINMAG-------AAITItvltlAAVHtlGIEVDLPTALLLSVVAAVSACGASGVA 342
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
267-526 7.96e-13

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 69.69  E-value: 7.96e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   267 NALGLVVFSVAFGLvigGMKHKGRVLRDFFDSLNEAIMRLVGIIIWYAPVGILFLIAGKILEMEDMAVlgGQLGMYTLTV 346
Cdd:PRK14695  60 NYIGILSWAVIFGI---AMREASKNSKELLKTIADVTSKIVEWIINLAPFGILGLVFKTISDKGVGSL--ANYGILLVLL 134
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   347 IVGLFLHAGIVLPLIYFLVTHRNPFPFIGGMLQ-ALITAMGTSSSSATLPITFRCLEEgLGVDRRITRFVLPVGATVNMD 425
Cdd:PRK14695 135 VTTMLFVAPVVNPLIAFFFMRRNPYPLVWNCLRvSGVTAFFTRSSATNIPVNMKLCHD-LGLNPDTYSVSIPLGSTINMA 213
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 4827012   426 GTALYEALAAIFIAQVNNYELNLGQITTISITATAASVGAAGIPQAGLVTMVIVLTSVGLPTEDITLIIAVDWFL----D 501
Cdd:PRK14695 214 GVAITINLLTLVTVNTLGIPVDFATAFVLSVVAAISACGASGIAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIgviqD 293
                        250       260
                 ....*....|....*....|....*
gi 4827012   502 RLRTMTNVLGDSIGAAVIEHLSQRE 526
Cdd:PRK14695 294 SCETALNSSTDVLFTAVAEYAATRK 318
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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