NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|53729352|ref|NP_005103|]
View 

WD repeat-containing protein 1 isoform 2 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-465 9.72e-51

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 9.72e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSvns 127
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--- 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 128 vvstfpmgstvldqqlgclwqkdhllsvslSGyinyldrnnpsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHIN 207
Cdd:COG2319 151 ------------------------------TG-----------KLLRTLTGHSGAVTSVAFSPDG--KLLASGSDDGTVR 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 208 YWDSETGEnDSFAGKGHTNQVSRMTVDESGQLI-SCSMDDTVRytslmLRDYSGQgvvkldvqpKCVAVGPGGYAVVVCi 286
Cdd:COG2319 188 LWDLATGK-LLRTLTGHTGAVRSVAFSPDGKLLaSGSADGTVR-----LWDLATG---------KLLRTLTGHSGSVRS- 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 287 gqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAV 366
Cdd:COG2319 252 ------------------------VAFSPDGRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 367 CDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQdAHRlHHVSSLAWL- 445
Cdd:COG2319 306 GSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHT-GAVTSVAFSp 382

                       410       420
                ....*....|....*....|
gi 53729352 446 DEHTLVTTSHDASVKEWTIT 465
Cdd:COG2319 383 DGRTLASGSADGTVRLWDLA 402
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-465 9.72e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 9.72e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSvns 127
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--- 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 128 vvstfpmgstvldqqlgclwqkdhllsvslSGyinyldrnnpsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHIN 207
Cdd:COG2319 151 ------------------------------TG-----------KLLRTLTGHSGAVTSVAFSPDG--KLLASGSDDGTVR 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 208 YWDSETGEnDSFAGKGHTNQVSRMTVDESGQLI-SCSMDDTVRytslmLRDYSGQgvvkldvqpKCVAVGPGGYAVVVCi 286
Cdd:COG2319 188 LWDLATGK-LLRTLTGHTGAVRSVAFSPDGKLLaSGSADGTVR-----LWDLATG---------KLLRTLTGHSGSVRS- 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 287 gqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAV 366
Cdd:COG2319 252 ------------------------VAFSPDGRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 367 CDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQdAHRlHHVSSLAWL- 445
Cdd:COG2319 306 GSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHT-GAVTSVAFSp 382

                       410       420
                ....*....|....*....|
gi 53729352 446 DEHTLVTTSHDASVKEWTIT 465
Cdd:COG2319 383 DGRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-419 9.00e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 150.18  E-value: 9.00e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  42 LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIW 121
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 122 DVSVNSVVSTFpmgstvldqqlgclwqkdhllsvslsgyinyldrnnpskplhviKGHSKSIQCLTVHKNGgkSYIYSGS 201
Cdd:cd00200  79 DLETGECVRTL--------------------------------------------TGHTSYVSSVAFSPDG--RILSSSS 112

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 202 HDGHINYWDSETGENdSFAGKGHTNQVSRMTVDESGQLISCSMDDtvrytslmlrdysgqGVVKL-DV-QPKCVAVGPGG 279
Cdd:cd00200 113 RDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPDGTFVASSSQD---------------GTIKLwDLrTGKCVATLTGH 176

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 280 YAVVVCigqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGNVRLYSILGTTLKdegKLLEAK-GPVTDVAYS 358
Cdd:cd00200 177 TGEVNS-------------------------VAFSPDGEKLLSSSSDGTIKLWDLSTGKCL---GTLRGHeNGVNSVAFS 228

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 53729352 359 HDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 419
Cdd:cd00200 229 PDGYLLASGSEDGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 42-77 1.01e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.01e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 53729352     42 LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYD 77
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 62-226 1.11e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352   62 NRFATASADGQIYIYDGKTGEKVCALggsKAHDGGIYAISWSP-DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLD 140
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEM---KEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICC 622

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  141 QQLGCLWQKDhLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLtvhKNGGKSYIYSGSHDGHINYWD---SETGEND 217
Cdd:PLN00181 623 VQFPSESGRS-LAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYV---RFVDSSTLVSSSTDNTLKLWDlsmSISGINE 698

                        170
                 ....*....|.
gi 53729352  218 S--FAGKGHTN 226
Cdd:PLN00181 699 TplHSFMGHTN 709
WD40 pfam00400
WD domain, G-beta repeat;
42-77 2.01e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.01e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 53729352    42 LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYD 77
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
48-465 9.72e-51

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 177.41  E-value: 9.72e-51
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  48 HSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSvns 127
Cdd:COG2319  77 HTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTG---HTGAVRSVAFSPDGKTLASGSADGTVRLWDLA--- 150

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 128 vvstfpmgstvldqqlgclwqkdhllsvslSGyinyldrnnpsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHIN 207
Cdd:COG2319 151 ------------------------------TG-----------KLLRTLTGHSGAVTSVAFSPDG--KLLASGSDDGTVR 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 208 YWDSETGEnDSFAGKGHTNQVSRMTVDESGQLI-SCSMDDTVRytslmLRDYSGQgvvkldvqpKCVAVGPGGYAVVVCi 286
Cdd:COG2319 188 LWDLATGK-LLRTLTGHTGAVRSVAFSPDGKLLaSGSADGTVR-----LWDLATG---------KLLRTLTGHSGSVRS- 251

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 287 gqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAV 366
Cdd:COG2319 252 ------------------------VAFSPDGRLLASGSADGTVRLWDL--ATGELLRTLTGHSGGVNSVAFSPDGKLLAS 305

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 367 CDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSDPETRVKIQdAHRlHHVSSLAWL- 445
Cdd:COG2319 306 GSDDGTVRLWDLATG-KLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLT-GHT-GAVTSVAFSp 382

                       410       420
                ....*....|....*....|
gi 53729352 446 DEHTLVTTSHDASVKEWTIT 465
Cdd:COG2319 383 DGRTLASGSADGTVRLWDLA 402
WD40 COG2319
WD40 repeat [General function prediction only];
41-423 1.18e-47

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.94  E-value: 1.18e-47
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  41 ILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKI 120
Cdd:COG2319 112 LLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTG---HSGAVTSVAFSPDGKLLASGSDDGTVRL 188

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 121 WDVSvnsvvstfpmgstvldqqlgclwqkdhllsvslSGyinyldrnnpsKPLHVIKGHSKSIQCLTVHKNGgkSYIYSG 200
Cdd:COG2319 189 WDLA---------------------------------TG-----------KLLRTLTGHTGAVRSVAFSPDG--KLLASG 222

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 201 SHDGHINYWDSETGEnDSFAGKGHTNQVSRMTVDESGQ-LISCSMDDTVRytslmLRDYSGQgvvkldvqpKCVAVGPGG 279
Cdd:COG2319 223 SADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSPDGRlLASGSADGTVR-----LWDLATG---------ELLRTLTGH 287

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 280 YAVVVCigqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGNVRLYSIlgttlkDEGKLLEA----KGPVTDV 355
Cdd:COG2319 288 SGGVNS-------------------------VAFSPDGKLLASGSDDGTVRLWDL------ATGKLLRTltghTGAVRSV 336

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 53729352 356 AYSHDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVWTLSD 423
Cdd:COG2319 337 AFSPDGKTLASGSDDGTVRLWDLATG-ELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 42-419 9.00e-42

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 150.18  E-value: 9.00e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  42 LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGDKTSKIW 121
Cdd:cd00200   2 RRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKG---HTGPVRDVAASADGTYLASGSSDKTIRLW 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 122 DVSVNSVVSTFpmgstvldqqlgclwqkdhllsvslsgyinyldrnnpskplhviKGHSKSIQCLTVHKNGgkSYIYSGS 201
Cdd:cd00200  79 DLETGECVRTL--------------------------------------------TGHTSYVSSVAFSPDG--RILSSSS 112

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 202 HDGHINYWDSETGENdSFAGKGHTNQVSRMTVDESGQLISCSMDDtvrytslmlrdysgqGVVKL-DV-QPKCVAVGPGG 279
Cdd:cd00200 113 RDKTIKVWDVETGKC-LTTLRGHTDWVNSVAFSPDGTFVASSSQD---------------GTIKLwDLrTGKCVATLTGH 176

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 280 YAVVVCigqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGNVRLYSILGTTLKdegKLLEAK-GPVTDVAYS 358
Cdd:cd00200 177 TGEVNS-------------------------VAFSPDGEKLLSSSSDGTIKLWDLSTGKCL---GTLRGHeNGVNSVAFS 228

                       330       340       350       360       370       380
                ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 53729352 359 HDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 419
Cdd:cd00200 229 PDGYLLASGSEDGTIRVWDLRTG-ECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIW 288
WD40 COG2319
WD40 repeat [General function prediction only];
35-380 2.52e-40

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 149.29  E-value: 2.52e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  35 TNGKCviLRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASG 114
Cdd:COG2319 150 ATGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTG---HTGAVRSVAFSPDGKLLASGSA 224

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 115 DKTSKIWDVsvnsvvstfpmgstvldqqlgclwqkdhllsvslsgyinyldrnNPSKPLHVIKGHSKSIQCLTVHKNGgk 194
Cdd:COG2319 225 DGTVRLWDL--------------------------------------------ATGKLLRTLTGHSGSVRSVAFSPDG-- 258

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 195 SYIYSGSHDGHINYWDSETGENDSFAGkGHTNQVSRMTVDESGQ-LISCSMDDTVRytslmLRDYSGqgvvkldvqPKCV 273
Cdd:COG2319 259 RLLASGSADGTVRLWDLATGELLRTLT-GHSGGVNSVAFSPDGKlLASGSDDGTVR-----LWDLAT---------GKLL 323

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 274 AVGPGGYAVVVCigqivllkdqrkcfsidnpgyepevVAVHPGGDTVAIGGVDGNVRLYSIlgTTLKDEGKLLEAKGPVT 353
Cdd:COG2319 324 RTLTGHTGAVRS-------------------------VAFSPDGKTLASGSDDGTVRLWDL--ATGELLRTLTGHTGAVT 376

                       330       340
                ....*....|....*....|....*..
gi 53729352 354 DVAYSHDGAFLAVCDASKVVTVFSVAD 380
Cdd:COG2319 377 SVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 36-249 3.41e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 115.90  E-value: 3.41e-29
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  36 NGKCVilRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGD 115
Cdd:cd00200  82 TGECV--RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRG---HTDWVNSVAFSPDGTFVASSSQD 156

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 116 KTSKIWDVSVNSVVSTFPmGSTvlDQQLGCLWQKD--HLLSVSLSGYInYLDRNNPSKPLHVIKGHSKSIQCLTVHKNGg 193
Cdd:cd00200 157 GTIKLWDLRTGKCVATLT-GHT--GEVNSVAFSPDgeKLLSSSSDGTI-KLWDLSTGKCLGTLRGHENGVNSVAFSPDG- 231

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*..
gi 53729352 194 kSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQVSRMTVDESGQ-LISCSMDDTVR 249
Cdd:cd00200 232 -YLLASGSEDGTIRVWDLRTGE-CVQTLSGHTNSVTSLAWSPDGKrLASGSADGTIR 286
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 172-462 1.21e-28

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 114.35  E-value: 1.21e-28
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 172 PLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWDSETGEnDSFAGKGHTNQVSR-MTVDESGQLISCSMDDTVRY 250
Cdd:cd00200   1 LRRTLKGHTGGVTCVAFSPDG--KLLATGSGDGTIKVWDLETGE-LLRTLKGHTGPVRDvAASADGTYLASGSSDKTIRL 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 251 TSL----MLRDYSG--QGVVKLDVQPKC-VAVGpGGYAVVVCIGQIVLLKDQRKCFSIDNPGYepeVVAVHPGGDTVAIG 323
Cdd:cd00200  78 WDLetgeCVRTLTGhtSYVSSVAFSPDGrILSS-SSRDKTIKVWDVETGKCLTTLRGHTDWVN---SVAFSPDGTFVASS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 324 GVDGNVRLYSIlgTTLKDEGKLLEAKGPVTDVAYSHDGAFLAVCDASKVVTVFSVADGySENNVFYGHHAKIVCLAWSPD 403
Cdd:cd00200 154 SQDGTIKLWDL--RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTG-KCLGTLRGHENGVNSVAFSPD 230

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 404 NEHFASGGMDMMVYVWTLSDPETRVKIQdAHRlHHVSSLAWL-DEHTLVTTSHDASVKEW 462
Cdd:cd00200 231 GYLLASGSEDGTIRVWDLRTGECVQTLS-GHT-NSVTSLAWSpDGKRLASGSADGTIRIW 288
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 36-210 4.13e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 95.86  E-value: 4.13e-22
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  36 NGKCVilRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALGGskaHDGGIYAISWSPDSTHLLSASGD 115
Cdd:cd00200 166 TGKCV--ATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRG---HENGVNSVAFSPDGYLLASGSED 240

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352 116 KTSKIWDVsvnsvvstfpmgstvldqqlgclwqkdhllsvslsgyinyldrnNPSKPLHVIKGHSKSIQCLTVHKNGgkS 195
Cdd:cd00200 241 GTIRVWDL--------------------------------------------RTGECVQTLSGHTNSVTSLAWSPDG--K 274

                       170
                ....*....|....*
gi 53729352 196 YIYSGSHDGHINYWD 210
Cdd:cd00200 275 RLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 42-77 1.01e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 48.08  E-value: 1.01e-07
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 53729352     42 LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYD 77
Cdd:smart00320   5 LKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 62-226 1.11e-06

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 51.24  E-value: 1.11e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352   62 NRFATASADGQIYIYDGKTGEKVCALggsKAHDGGIYAISWSP-DSTHLLSASGDKTSKIWDVSVNSVVSTFPMGSTVLD 140
Cdd:PLN00181 546 SQVASSNFEGVVQVWDVARSQLVTEM---KEHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICC 622

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  141 QQLGCLWQKDhLLSVSLSGYINYLDRNNPSKPLHVIKGHSKSIQCLtvhKNGGKSYIYSGSHDGHINYWD---SETGEND 217
Cdd:PLN00181 623 VQFPSESGRS-LAFGSADHKVYYYDLRNPKLPLCTMIGHSKTVSYV---RFVDSSTLVSSSTDNTLKLWDlsmSISGINE 698

                        170
                 ....*....|.
gi 53729352  218 S--FAGKGHTN 226
Cdd:PLN00181 699 TplHSFMGHTN 709
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 91-122 1.57e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.61  E-value: 1.57e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 53729352     91 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 122
Cdd:smart00320   9 KGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
42-77 2.01e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.01e-06
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 53729352    42 LRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYD 77
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 386-419 2.53e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 44.23  E-value: 2.53e-06
                           10        20        30
                   ....*....|....*....|....*....|....
gi 53729352    386 NVFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 419
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLW 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 169-210 6.37e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 43.07  E-value: 6.37e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 53729352    169 PSKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWD 210
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDG--KYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
91-122 8.27e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 42.72  E-value: 8.27e-06
                          10        20        30
                  ....*....|....*....|....*....|..
gi 53729352    91 KAHDGGIYAISWSPDSTHLLSASGDKTSKIWD 122
Cdd:pfam00400   8 EGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 55-124 1.25e-05

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 47.73  E-value: 1.25e-05
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 53729352   55 VRFSPDGNRFATAS-ADG--QIYIYDGKTGEKVCALggSKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVS 124
Cdd:COG4946  348 PAWSPDGKSIAYFSdASGeyELYIAPADGSGEPKQL--TLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLA 418
WD40 pfam00400
WD domain, G-beta repeat;
387-419 1.26e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.26e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 53729352   387 VFYGHHAKIVCLAWSPDNEHFASGGMDMMVYVW 419
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVW 38
WD40 pfam00400
WD domain, G-beta repeat;
170-210 2.06e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.56  E-value: 2.06e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 53729352   170 SKPLHVIKGHSKSIQCLTVHKNGgkSYIYSGSHDGHINYWD 210
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDG--KLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 52-241 2.58e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 46.62  E-value: 2.58e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352   52 VNCVRFSPD-GNRFATASADGQIYIYDGKTGE-KVCALGGskaHDGGIYAISWSpDSTHLLSASGDKTSKIWDvsvnsvv 129
Cdd:PLN00181 620 ICCVQFPSEsGRSLAFGSADHKVYYYDLRNPKlPLCTMIG---HSKTVSYVRFV-DSSTLVSSSTDNTLKLWD------- 688

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  130 stfpmgstvldqqlgclwqkdhlLSVSLSGyINyldrnnpSKPLHVIKGHS--KSIQCLTVhkngGKSYIYSGSHDGHI- 206
Cdd:PLN00181 689 -----------------------LSMSISG-IN-------ETPLHSFMGHTnvKNFVGLSV----SDGYIATGSETNEVf 733

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 53729352  207 NYWDSETGENDSFAGKgHTNQVSRMTVDESGQLIS 241
Cdd:PLN00181 734 VYHKAFPMPVLSYKFK-TIDPVSGLEVDDASQFIS 767
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 35-103 4.68e-05

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 41.88  E-value: 4.68e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 53729352    35 TNGKCVILRNIDDHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEKVCALggsKAHDGGIYAISWS 103
Cdd:pfam12894  24 LNWQRVWTLSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHF---SAGSDLITCLGWG 89
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 47-255 1.64e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 44.31  E-value: 1.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352   47 DHSRFVNCVRFSPDGNRFATASADGQIYIYDGKTGEK--------VCALGGSKAHDGgiyaISW-SPDSTHLLSASGDKT 117
Cdd:PLN00181 481 NSSNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKdgrdihypVVELASRSKLSG----ICWnSYIKSQVASSNFEGV 556

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  118 SKIWDVSVNSVVstfpmgsTVLDQQLGCLWQKDH-------LLSVSLSGYINyLDRNNPSKPLHVIKGHSkSIQCLTVHK 190
Cdd:PLN00181 557 VQVWDVARSQLV-------TEMKEHEKRVWSIDYssadptlLASGSDDGSVK-LWSINQGVSIGTIKTKA-NICCVQFPS 627

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 53729352  191 NGGKSYIYsGSHDGHINYWDSETGENDSFAGKGHTNQVSRMTVDESGQLISCSMDDTVRYTSLML 255
Cdd:PLN00181 628 ESGRSLAF-GSADHKVYYYDLRNPKLPLCTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDLSM 691
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 56-136 2.03e-04

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 41.58  E-value: 2.03e-04
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  56 RFSPDGNRFATASADG---QIYIYDGKTGEkvcalggSKAHDGGIYAISWSPDSTHLL-SASGDKTSKIWDVSVNSVVST 131
Cdd:COG0823  81 SWSPDGKRLAFVSRSDgrfDIYVLDLDGGA-------PRRLTDGPGSPSWSPDGRRIVfSSDRGGRPDLYVVDLDGRKRR 153


                ....*
gi 53729352 132 FPMGS 136
Cdd:COG0823 154 LTPAS 158
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 65-137 3.90e-04

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 39.18  E-value: 3.90e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 53729352    65 ATASADGQIYIYDGKtGEKVCALGGSKaHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVNSVVSTFPMGST 137
Cdd:pfam12894  11 ALATEDGELLLHRLN-WQRVWTLSPDK-EDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSD 81
IKI3 pfam04762
IKI3 family; Members of this family are components of the elongator multi-subunit component of ...
 64-123 4.32e-04

IKI3 family; Members of this family are components of the elongator multi-subunit component of a novel RNA polymerase II holoenzyme for transcriptional elongation. This region contains WD40 like repeats.


Pssm-ID: 428111 [Multi-domain]  Cd Length: 933  Bit Score: 43.08  E-value: 4.32e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 53729352    64 FATASADGQIYIYDGKTGEKVCALGGSKahDGGIYAISWSPDSTHLLSASGDKT----SKIWDV 123
Cdd:pfam04762  92 FASASGDIILVTYDPDPETTVVEIVGSI--DSGITAAAWSPDEELLALVTGEGTvllmTRDFEP 153
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 320-465 5.34e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.38  E-value: 5.34e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352  320 VAIGGVDGNVRLYSILGTTLKDEGKllEAKGPVTDVAYSH-DGAFLAVCDASKVVTVFSVADGYSENNVfyGHHAKIVCL 398
Cdd:PLN00181 548 VASSNFEGVVQVWDVARSQLVTEMK--EHEKRVWSIDYSSaDPTLLASGSDDGSVKLWSINQGVSIGTI--KTKANICCV 623

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 53729352  399 AWSPDN-EHFASGGMDMMVYVWTLSDPETRVKIQDAHRlHHVSSLAWLDEHTLVTTSHDASVKEWTIT 465
Cdd:PLN00181 624 QFPSESgRSLAFGSADHKVYYYDLRNPKLPLCTMIGHS-KTVSYVRFVDSSTLVSSSTDNTLKLWDLS 690
PTZ00421 PTZ00421
coronin; Provisional
 48-157 1.43e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 41.03  E-value: 1.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352   48 HSRFVNCVRFSPDG-NRFATASADGQIYIYDGKTGEKVCALggsKAHDGGIYAISWSPDSTHLLSASGDKTSKIWDVSVN 126
Cdd:PTZ00421 124 HTKKVGIVSFHPSAmNVLASAGADMVVNVWDVERGKAVEVI---KCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDG 200

                         90       100       110
                 ....*....|....*....|....*....|.
gi 53729352  127 SVVSTFPMGSTVLDQQlgCLWQKDHLLSVSL 157
Cdd:PTZ00421 201 TIVSSVEAHASAKSQR--CLWAKRKDLIITL 229
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 36-124 2.77e-03

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 38.79  E-value: 2.77e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 53729352    36 NGKCVILRNIDDHSRfvNCVRFSPDGNRFATA---SADGQIYIYDGKTGEKVCALGGSKAHDggiyaISWSPDSTHLLSA 112
Cdd:pfam08662  89 DLKGNVIHSFGEQPR--NTIFWSPFGRLVLLAgfgNLAGDIEFWDVVNKKKIATAEASNATL-----CEWSPDGRYFLTA 161

                          90
                  ....*....|....*...
gi 53729352   113 SG------DKTSKIWDVS 124
Cdd:pfam08662 162 TTaprlrvDNGFKIWHYN 179
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 56-106 3.10e-03

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 40.02  E-value: 3.10e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 53729352   56 RFSPDGNRFATASADGQIYIYDGKTGE--KVcalgGSKAHDGGIYAISWSPDS 106
Cdd:COG4946  395 VWSPDGKKIAFTDNRGRLWVVDLASGKvrKV----DTDGYGDGISDLAWSPDS 443
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH