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Conserved domains on  [gi|148491103|ref|NP_005203|]
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kappa-casein precursor [Homo sapiens]

Protein Classification

Casein_kappa domain-containing protein( domain architecture ID 10470039)

Casein_kappa domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Casein_kappa pfam00997
Kappa casein; Kappa-casein is a mammalian milk protein involved in a number of important ...
 21-171 4.79e-71

Kappa casein; Kappa-casein is a mammalian milk protein involved in a number of important physiological processes. In the gut, the ingested protein is split into an insoluble peptide (para kappa-casein) and a soluble hydrophilic glycopeptide (caseinomacropeptide). Caseinomacropeptide is responsible for increased efficiency of digestion, prevention of neonate hypersensitivity to ingested proteins, and inhibition of gastric pathogens.


:

Pssm-ID: 460021  Cd Length: 160  Bit Score: 211.94  E-value: 4.79e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491103   21 EVQNQKQPACHENDERPFYQKTAPYVPMYYVPNSYPYYGTNLYQRRPAIAINNPYVPRTYYANPAVVRPHAQIPQRQYLP 100
Cdd:pfam00997   1 EVQNQEQPTCCENDERLFDQKTVKYIPIHYVLNSYPHYEPNYYQHRPAVPINNPYMPYPYYAKPVVVRPHAQIPQWQVLP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148491103  101 NSHPPTVVRRPNLHPSFIAIPPKKIQDKIIIPTINTIATVEPTPAPATEPTVDSVVTPEAFSESIItSTPE 171
Cdd:pfam00997  81 NIYPPTVVRHPIPHPSFIAIPPKKIQDKTAIPTINTIATVEPTPVPTTEPVVNTVVTPEASSEFII-STPE 150
 
Name Accession Description Interval E-value
Casein_kappa pfam00997
Kappa casein; Kappa-casein is a mammalian milk protein involved in a number of important ...
 21-171 4.79e-71

Kappa casein; Kappa-casein is a mammalian milk protein involved in a number of important physiological processes. In the gut, the ingested protein is split into an insoluble peptide (para kappa-casein) and a soluble hydrophilic glycopeptide (caseinomacropeptide). Caseinomacropeptide is responsible for increased efficiency of digestion, prevention of neonate hypersensitivity to ingested proteins, and inhibition of gastric pathogens.


Pssm-ID: 460021  Cd Length: 160  Bit Score: 211.94  E-value: 4.79e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491103   21 EVQNQKQPACHENDERPFYQKTAPYVPMYYVPNSYPYYGTNLYQRRPAIAINNPYVPRTYYANPAVVRPHAQIPQRQYLP 100
Cdd:pfam00997   1 EVQNQEQPTCCENDERLFDQKTVKYIPIHYVLNSYPHYEPNYYQHRPAVPINNPYMPYPYYAKPVVVRPHAQIPQWQVLP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148491103  101 NSHPPTVVRRPNLHPSFIAIPPKKIQDKIIIPTINTIATVEPTPAPATEPTVDSVVTPEAFSESIItSTPE 171
Cdd:pfam00997  81 NIYPPTVVRHPIPHPSFIAIPPKKIQDKTAIPTINTIATVEPTPVPTTEPVVNTVVTPEASSEFII-STPE 150
 
Name Accession Description Interval E-value
Casein_kappa pfam00997
Kappa casein; Kappa-casein is a mammalian milk protein involved in a number of important ...
 21-171 4.79e-71

Kappa casein; Kappa-casein is a mammalian milk protein involved in a number of important physiological processes. In the gut, the ingested protein is split into an insoluble peptide (para kappa-casein) and a soluble hydrophilic glycopeptide (caseinomacropeptide). Caseinomacropeptide is responsible for increased efficiency of digestion, prevention of neonate hypersensitivity to ingested proteins, and inhibition of gastric pathogens.


Pssm-ID: 460021  Cd Length: 160  Bit Score: 211.94  E-value: 4.79e-71
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 148491103   21 EVQNQKQPACHENDERPFYQKTAPYVPMYYVPNSYPYYGTNLYQRRPAIAINNPYVPRTYYANPAVVRPHAQIPQRQYLP 100
Cdd:pfam00997   1 EVQNQEQPTCCENDERLFDQKTVKYIPIHYVLNSYPHYEPNYYQHRPAVPINNPYMPYPYYAKPVVVRPHAQIPQWQVLP 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 148491103  101 NSHPPTVVRRPNLHPSFIAIPPKKIQDKIIIPTINTIATVEPTPAPATEPTVDSVVTPEAFSESIItSTPE 171
Cdd:pfam00997  81 NIYPPTVVRHPIPHPSFIAIPPKKIQDKTAIPTINTIATVEPTPVPTTEPVVNTVVTPEASSEFII-STPE 150
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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