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Conserved domains on  [gi|222352170|ref|NP_005374|]
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sialidase-2 [Homo sapiens]

Protein Classification

sialidase family protein( domain architecture ID 10202570)

sialidase (glycoside hydrolase 33) family protein such as non-viral exo-alpha-sialidase that catalyzes the removal of sialic acid (N-acetylneuraminic acid) moieties from glycoproteins, oligosaccharides and gangliosides

CATH:  2.120.10.10
CAZY:  GH33
EC:  3.2.1.-
PubMed:  7934919|8994884
SCOP:  3001607

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
14-368 1.78e-68

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


:

Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 219.25  E-value: 1.78e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  14 QSGAHAYRIPALLYLPGQqSLLAFAEQRASKKDEHAE--LIVLRRGDYDAPThqvqWQAQEVVAQARL-DGHRSMNPCPL 90
Cdd:cd15482    8 DEGSDSYRIPSLVTTPNG-TLLAFADGRYEGAGDLGGdiDIVVRRSTDGGKT----WSEPVTVVDGGGsGGASYGDPSLV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  91 YDAQTGTLFLFFIAIPGQVteqQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPayrEWSTFAVGPGHCLQLHD- 169
Cdd:cd15482   83 VDPDTGRIFLFYTSGPGGG---GEALTGDGTVRVRLSTSDDDGKTWSEPRDLTPQVKPS---GWKFFFTGPGRGIQLSDg 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170 170 RarsLVVPAYAYRKLHPIQRpipsAFCFLSHDHGRTWARGHFVAQDTL---ECQVAEVETGeqRVVtLNARS--HLRARV 244
Cdd:cd15482  157 R---LVFPAYARNGGGGGDG----AVVIYSDDGGKTWTRGGGVPSSGAggdEPSIVELSDG--RLL-MNARNsgGGGGRA 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170 245 QAQSTNDGLDFQESQLVKKLVEPppqGCQGSVISFPSPRSGpgspaqWLLYTHPTHS-WQRADLGAYLNPRPPApeAWSE 323
Cdd:cd15482  227 VAESTDGGETWSEPVPTPSLPDP---GCQGSLIRLPDGGRK------VLLFSNPASPgKGRTNLTLRLSDDGGK--TWPD 295
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 222352170 324 PVLLAKGS-CAYSDLQSMgtgPDGSplFGCLYEAND---YEEIVFLMFT 368
Cdd:cd15482  296 VRVLEDGPgSGYSSLTQL---PDGT--IGLLYEEGRgggYEGIKFARLT 339
 
Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
14-368 1.78e-68

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 219.25  E-value: 1.78e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  14 QSGAHAYRIPALLYLPGQqSLLAFAEQRASKKDEHAE--LIVLRRGDYDAPThqvqWQAQEVVAQARL-DGHRSMNPCPL 90
Cdd:cd15482    8 DEGSDSYRIPSLVTTPNG-TLLAFADGRYEGAGDLGGdiDIVVRRSTDGGKT----WSEPVTVVDGGGsGGASYGDPSLV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  91 YDAQTGTLFLFFIAIPGQVteqQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPayrEWSTFAVGPGHCLQLHD- 169
Cdd:cd15482   83 VDPDTGRIFLFYTSGPGGG---GEALTGDGTVRVRLSTSDDDGKTWSEPRDLTPQVKPS---GWKFFFTGPGRGIQLSDg 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170 170 RarsLVVPAYAYRKLHPIQRpipsAFCFLSHDHGRTWARGHFVAQDTL---ECQVAEVETGeqRVVtLNARS--HLRARV 244
Cdd:cd15482  157 R---LVFPAYARNGGGGGDG----AVVIYSDDGGKTWTRGGGVPSSGAggdEPSIVELSDG--RLL-MNARNsgGGGGRA 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170 245 QAQSTNDGLDFQESQLVKKLVEPppqGCQGSVISFPSPRSGpgspaqWLLYTHPTHS-WQRADLGAYLNPRPPApeAWSE 323
Cdd:cd15482  227 VAESTDGGETWSEPVPTPSLPDP---GCQGSLIRLPDGGRK------VLLFSNPASPgKGRTNLTLRLSDDGGK--TWPD 295
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 222352170 324 PVLLAKGS-CAYSDLQSMgtgPDGSplFGCLYEAND---YEEIVFLMFT 368
Cdd:cd15482  296 VRVLEDGPgSGYSSLTQL---PDGT--IGLLYEEGRgggYEGIKFARLT 339
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
1-370 7.62e-65

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 210.95  E-value: 7.62e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170   1 MASLPVLQKESVFQSG---AHAYRIPALLYLP-GqqSLLAFAEQR-ASKKDEHAEL-IVLRRGDYDAPThqvqWQAQEVV 74
Cdd:COG4409   15 LTAVAALTETAVFTSGddgYASYRIPALVTTPkG--TLLAFADARyNGSGDLPGDIdIVMRRSTDGGKT----WSPPQVI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  75 AQARLDGHRS---MNPCPLYDAQTGTLFLFFIAIPGQVTEQ----QQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAI 147
Cdd:COG4409   89 LDYGEGGGLSagvGDPAPVVDRKTGRIFLLADWMPGNDGEGwsgsEPGTDPKGTRQLWVTYSDDDGKTWSEPRNITPQVK 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170 148 GPayrEWSTFAVGPGHCLQLHDRARS--LVVPAYaYRklhpiQRPIPSAFCFLSHDHGRTWARGHFVAQD--TLECQVAE 223
Cdd:COG4409  169 DP---DWRFLATGPGHGIQLKNGEHKgrLVFPAY-YS-----DGGKPSAAVIYSDDHGKTWKLGESANDKanTNEAQVVE 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170 224 VETGeqrVVTLNARSHLRA--RVQAQSTNDGLDFQESQLVKKLVEPppqGCQGSVISFpsprsGPGSPAQWLLYTHPTHS 301
Cdd:COG4409  240 LSDG---RLMLNMRNQSGGgkRAVATSKDGGETWSEVTFDPALPEP---VCQASIIRY-----DKGDGKDVLLFSNPASP 308
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 222352170 302 WQRADLGAYLNprppAPEA--WSEPVLLAKGSCAYSDLQSMgtgPDGSplFGCLYEANDYEEIVFLMFTLK 370
Cdd:COG4409  309 KGRKNGTVRLS----YDDGktWPYSKVIEPGGSAYSCLTVL---DDGT--IGLLYERGDAGNIVFARFPLD 370
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
34-343 1.56e-56

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 186.38  E-value: 1.56e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170   34 LLAFAEqrASKKDEHAELIVLRRGDydapTHQV-QWQAQEVVA---QARLDGHRSMNPCPLYDAqTGTLFLFFIAIPGQV 109
Cdd:pfam13088   3 LLAAWF--GGSREGAPDVSIWRSVF----DPGSnKWSAPQVVAdgeQLGRYIRKLGNPVLFRDP-GGTLVLFYKVGVSPG 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  110 TEQqqlqtRANVTRlcqVTSTDHGRTWSSPRDLTDAaigpayreWSTFAVGPGHCLQLHDRARSLVVPAYayrklHPIQR 189
Cdd:pfam13088  76 GWA-----GSKIYR---ITSSDNGRTWSAPRRLPPG--------PFLNISGPVKNKPVQLADGRLLLPSY-----HELAG 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  190 PiPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVtLNARSHLRARVQAQSTNDGLDFQESQlvkklveppp 269
Cdd:pfam13088 135 K-WAAHLELSDDGGVTWRKGRPDNAISGELQPSVLVLADGRLV-MLFRSQEGAILASESTDGGLTWSPPE---------- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  270 qgcqgsVISFPSPRSGP-----GSPAQWLLYTHPTHSWQRADLGAYLnpRPPAPEAWSEPVLLAKGS---CAYSDLQSMG 341
Cdd:pfam13088 203 ------PTNLPNPNSGIdavnlPDGRLLLVYNPPNAGKPRGPLALAL--SEDGGKSWEEVLTLEDGPgdeYSYPSLIQAR 274

                  ..
gi 222352170  342 TG 343
Cdd:pfam13088 275 DG 276
 
Name Accession Description Interval E-value
Sialidase_non-viral cd15482
Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal ...
14-368 1.78e-68

Non-viral sialidases; Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates, they play vital roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold with the non-viral sialidases containing 2-5 Asp-box motifs (most commonly Ser/Thr-X-Asp-[X]-Gly-X-Thr- Trp/Phe). This CD includes eubacterial and eukaryotic sialidases.


Pssm-ID: 271234 [Multi-domain]  Cd Length: 339  Bit Score: 219.25  E-value: 1.78e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  14 QSGAHAYRIPALLYLPGQqSLLAFAEQRASKKDEHAE--LIVLRRGDYDAPThqvqWQAQEVVAQARL-DGHRSMNPCPL 90
Cdd:cd15482    8 DEGSDSYRIPSLVTTPNG-TLLAFADGRYEGAGDLGGdiDIVVRRSTDGGKT----WSEPVTVVDGGGsGGASYGDPSLV 82
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  91 YDAQTGTLFLFFIAIPGQVteqQQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAIGPayrEWSTFAVGPGHCLQLHD- 169
Cdd:cd15482   83 VDPDTGRIFLFYTSGPGGG---GEALTGDGTVRVRLSTSDDDGKTWSEPRDLTPQVKPS---GWKFFFTGPGRGIQLSDg 156
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170 170 RarsLVVPAYAYRKLHPIQRpipsAFCFLSHDHGRTWARGHFVAQDTL---ECQVAEVETGeqRVVtLNARS--HLRARV 244
Cdd:cd15482  157 R---LVFPAYARNGGGGGDG----AVVIYSDDGGKTWTRGGGVPSSGAggdEPSIVELSDG--RLL-MNARNsgGGGGRA 226
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170 245 QAQSTNDGLDFQESQLVKKLVEPppqGCQGSVISFPSPRSGpgspaqWLLYTHPTHS-WQRADLGAYLNPRPPApeAWSE 323
Cdd:cd15482  227 VAESTDGGETWSEPVPTPSLPDP---GCQGSLIRLPDGGRK------VLLFSNPASPgKGRTNLTLRLSDDGGK--TWPD 295
                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 222352170 324 PVLLAKGS-CAYSDLQSMgtgPDGSplFGCLYEAND---YEEIVFLMFT 368
Cdd:cd15482  296 VRVLEDGPgSGYSSLTQL---PDGT--IGLLYEEGRgggYEGIKFARLT 339
NanH COG4409
Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate ...
1-370 7.62e-65

Neuraminidase (sialidase) NanH, contains C-terminal autotransporter domain [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443531 [Multi-domain]  Cd Length: 376  Bit Score: 210.95  E-value: 7.62e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170   1 MASLPVLQKESVFQSG---AHAYRIPALLYLP-GqqSLLAFAEQR-ASKKDEHAEL-IVLRRGDYDAPThqvqWQAQEVV 74
Cdd:COG4409   15 LTAVAALTETAVFTSGddgYASYRIPALVTTPkG--TLLAFADARyNGSGDLPGDIdIVMRRSTDGGKT----WSPPQVI 88
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  75 AQARLDGHRS---MNPCPLYDAQTGTLFLFFIAIPGQVTEQ----QQLQTRANVTRLCQVTSTDHGRTWSSPRDLTDAAI 147
Cdd:COG4409   89 LDYGEGGGLSagvGDPAPVVDRKTGRIFLLADWMPGNDGEGwsgsEPGTDPKGTRQLWVTYSDDDGKTWSEPRNITPQVK 168
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170 148 GPayrEWSTFAVGPGHCLQLHDRARS--LVVPAYaYRklhpiQRPIPSAFCFLSHDHGRTWARGHFVAQD--TLECQVAE 223
Cdd:COG4409  169 DP---DWRFLATGPGHGIQLKNGEHKgrLVFPAY-YS-----DGGKPSAAVIYSDDHGKTWKLGESANDKanTNEAQVVE 239
                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170 224 VETGeqrVVTLNARSHLRA--RVQAQSTNDGLDFQESQLVKKLVEPppqGCQGSVISFpsprsGPGSPAQWLLYTHPTHS 301
Cdd:COG4409  240 LSDG---RLMLNMRNQSGGgkRAVATSKDGGETWSEVTFDPALPEP---VCQASIIRY-----DKGDGKDVLLFSNPASP 308
                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 222352170 302 WQRADLGAYLNprppAPEA--WSEPVLLAKGSCAYSDLQSMgtgPDGSplFGCLYEANDYEEIVFLMFTLK 370
Cdd:COG4409  309 KGRKNGTVRLS----YDDGktWPYSKVIEPGGSAYSCLTVL---DDGT--IGLLYERGDAGNIVFARFPLD 370
BNR_2 pfam13088
BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these ...
34-343 1.56e-56

BNR repeat-like domain; This family of proteins contains BNR-like repeats suggesting these proteins may act as sialidases.


Pssm-ID: 463781 [Multi-domain]  Cd Length: 280  Bit Score: 186.38  E-value: 1.56e-56
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170   34 LLAFAEqrASKKDEHAELIVLRRGDydapTHQV-QWQAQEVVA---QARLDGHRSMNPCPLYDAqTGTLFLFFIAIPGQV 109
Cdd:pfam13088   3 LLAAWF--GGSREGAPDVSIWRSVF----DPGSnKWSAPQVVAdgeQLGRYIRKLGNPVLFRDP-GGTLVLFYKVGVSPG 75
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  110 TEQqqlqtRANVTRlcqVTSTDHGRTWSSPRDLTDAaigpayreWSTFAVGPGHCLQLHDRARSLVVPAYayrklHPIQR 189
Cdd:pfam13088  76 GWA-----GSKIYR---ITSSDNGRTWSAPRRLPPG--------PFLNISGPVKNKPVQLADGRLLLPSY-----HELAG 134
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  190 PiPSAFCFLSHDHGRTWARGHFVAQDTLECQVAEVETGEQRVVtLNARSHLRARVQAQSTNDGLDFQESQlvkklveppp 269
Cdd:pfam13088 135 K-WAAHLELSDDGGVTWRKGRPDNAISGELQPSVLVLADGRLV-MLFRSQEGAILASESTDGGLTWSPPE---------- 202
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  270 qgcqgsVISFPSPRSGP-----GSPAQWLLYTHPTHSWQRADLGAYLnpRPPAPEAWSEPVLLAKGS---CAYSDLQSMG 341
Cdd:pfam13088 203 ------PTNLPNPNSGIdavnlPDGRLLLVYNPPNAGKPRGPLALAL--SEDGGKSWEEVLTLEDGPgdeYSYPSLIQAR 274

                  ..
gi 222352170  342 TG 343
Cdd:pfam13088 275 DG 276
COG4692 COG4692
Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane ...
67-252 1.30e-06

Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism, Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443727 [Multi-domain]  Cd Length: 353  Bit Score: 49.93  E-value: 1.30e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170  67 QWQAQEVVAQARLD--GHRSMNPCpLYDAQTGTLFLFFIAIP--GQVTEqqqlqtranvtRLCQVTSTDHGRTWSSPRDL 142
Cdd:COG4692   83 KWSAPVRVATGEQDdpRRPLWNPV-LFLAPDGRLWLFYKVPSpgGWWGS-----------LIRVRTSTDGGKTWSPPERL 150
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 222352170 143 TDAAIGPayrewSTFAvgpghclqlhdrarslvvpayayrKLHPIQRP-----IPSAFCFLSH---------DHGRTWAR 208
Cdd:COG4692  151 PEGPFLI-----GGPV------------------------RNKPVVLSdgrilLPSYTESGGKwrshveisdDGGKTWTK 201
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*....
gi 222352170 209 -----GHFVAQDTLecqvaeVETGEQRVVTLnARSHLRARVQAQSTNDG 252
Cdd:COG4692  202 spipkGFGAIQPSI------LELKDGRLQAL-MRSRGAGRIYRSESTDG 243
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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