NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|4885629|ref|NP_005414|]
View 

trefoil factor 2 precursor [Homo sapiens]

Protein Classification

Trefoil domain-containing protein( domain architecture ID 10635785)

Trefoil domain-containing protein

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 79-124 2.85e-14

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


:

Pssm-ID: 197472  Cd Length: 46  Bit Score: 62.02  E-value: 2.85e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 4885629      79 DQCVMEVSDRRNCGYPGISPEECASRKCCFSNFIFEVPWCFFPKSV 124
Cdd:smart00018   1 AQCSVPPSERINCGPPGITEAECEARGCCFDSSISGVPWCFYPNTV 46
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 29-75 7.32e-12

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


:

Pssm-ID: 197472  Cd Length: 46  Bit Score: 55.85  E-value: 7.32e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4885629      29 CQCSRlSPHNRTNCGFPGITSDQCFDNGCCFDSSVTGVPWCFHPLPK 75
Cdd:smart00018   1 AQCSV-PPSERINCGPPGITEAECEARGCCFDSSISGVPWCFYPNTV 46
 
Name Accession Description Interval E-value
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 79-124 2.85e-14

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


Pssm-ID: 197472  Cd Length: 46  Bit Score: 62.02  E-value: 2.85e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 4885629      79 DQCVMEVSDRRNCGYPGISPEECASRKCCFSNFIFEVPWCFFPKSV 124
Cdd:smart00018   1 AQCSVPPSERINCGPPGITEAECEARGCCFDSSISGVPWCFYPNTV 46
Trefoil cd00111
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated ...
 79-122 5.06e-13

P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.


Pssm-ID: 238059  Cd Length: 44  Bit Score: 58.89  E-value: 5.06e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 4885629   79 DQCVMEVSDRRNCGYPGISPEECASRKCCFSNFIFEVPWCFFPK 122
Cdd:cd00111   1 EWCSVPPSERIDCGPPGITQEECEARGCCFDPSISGVPWCFYPK 44
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 29-75 7.32e-12

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


Pssm-ID: 197472  Cd Length: 46  Bit Score: 55.85  E-value: 7.32e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4885629      29 CQCSRlSPHNRTNCGFPGITSDQCFDNGCCFDSSVTGVPWCFHPLPK 75
Cdd:smart00018   1 AQCSV-PPSERINCGPPGITEAECEARGCCFDSSISGVPWCFYPNTV 46
Trefoil pfam00088
Trefoil (P-type) domain;
31-72 4.05e-11

Trefoil (P-type) domain;


Pssm-ID: 459666  Cd Length: 43  Bit Score: 53.86  E-value: 4.05e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 4885629     31 CSRLSPHNRTNCGFPGITSDQCFDNGCCFDSSVT-GVPWCFHP 72
Cdd:pfam00088   1 CSSVPPSDRFDCGYPGITQEECEARGCCWDPSVDpGVPWCFYP 43
Trefoil cd00111
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated ...
 36-72 9.03e-10

P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.


Pssm-ID: 238059  Cd Length: 44  Bit Score: 50.42  E-value: 9.03e-10
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 4885629   36 PHNRTNCGFPGITSDQCFDNGCCFDSSVTGVPWCFHP 72
Cdd:cd00111   7 PSERIDCGPPGITQEECEARGCCFDPSISGVPWCFYP 43
Trefoil pfam00088
Trefoil (P-type) domain;
82-121 7.63e-09

Trefoil (P-type) domain;


Pssm-ID: 459666  Cd Length: 43  Bit Score: 48.08  E-value: 7.63e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 4885629     82 VMEVSDRRNCGYPGISPEECASRKCCF-SNFIFEVPWCFFP 121
Cdd:pfam00088   3 SVPPSDRFDCGYPGITQEECEARGCCWdPSVDPGVPWCFYP 43
 
Name Accession Description Interval E-value
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 79-124 2.85e-14

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


Pssm-ID: 197472  Cd Length: 46  Bit Score: 62.02  E-value: 2.85e-14
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 4885629      79 DQCVMEVSDRRNCGYPGISPEECASRKCCFSNFIFEVPWCFFPKSV 124
Cdd:smart00018   1 AQCSVPPSERINCGPPGITEAECEARGCCFDSSISGVPWCFYPNTV 46
Trefoil cd00111
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated ...
 79-122 5.06e-13

P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.


Pssm-ID: 238059  Cd Length: 44  Bit Score: 58.89  E-value: 5.06e-13
                        10        20        30        40
                ....*....|....*....|....*....|....*....|....
gi 4885629   79 DQCVMEVSDRRNCGYPGISPEECASRKCCFSNFIFEVPWCFFPK 122
Cdd:cd00111   1 EWCSVPPSERIDCGPPGITQEECEARGCCFDPSISGVPWCFYPK 44
PD smart00018
P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.
 29-75 7.32e-12

P or trefoil or TFF domain; Proposed role in renewal and pathology of mucous epithelia.


Pssm-ID: 197472  Cd Length: 46  Bit Score: 55.85  E-value: 7.32e-12
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 4885629      29 CQCSRlSPHNRTNCGFPGITSDQCFDNGCCFDSSVTGVPWCFHPLPK 75
Cdd:smart00018   1 AQCSV-PPSERINCGPPGITEAECEARGCCFDSSISGVPWCFYPNTV 46
Trefoil pfam00088
Trefoil (P-type) domain;
31-72 4.05e-11

Trefoil (P-type) domain;


Pssm-ID: 459666  Cd Length: 43  Bit Score: 53.86  E-value: 4.05e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 4885629     31 CSRLSPHNRTNCGFPGITSDQCFDNGCCFDSSVT-GVPWCFHP 72
Cdd:pfam00088   1 CSSVPPSDRFDCGYPGITQEECEARGCCWDPSVDpGVPWCFYP 43
Trefoil cd00111
P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated ...
 36-72 9.03e-10

P or trefoil or TFF domain; Trefoil factor family domain peptides are mucin-associated molecules, largely found in epithelia of gastrointestinal tissues. Function is not known but it was originally identified from mucosal tissues, where it may have a regulatory or structural role and has also been implicated as a growth fractor in other tissues.The domain is found in 1 to 6 copies where it occurs.


Pssm-ID: 238059  Cd Length: 44  Bit Score: 50.42  E-value: 9.03e-10
                        10        20        30
                ....*....|....*....|....*....|....*..
gi 4885629   36 PHNRTNCGFPGITSDQCFDNGCCFDSSVTGVPWCFHP 72
Cdd:cd00111   7 PSERIDCGPPGITQEECEARGCCFDPSISGVPWCFYP 43
Trefoil pfam00088
Trefoil (P-type) domain;
82-121 7.63e-09

Trefoil (P-type) domain;


Pssm-ID: 459666  Cd Length: 43  Bit Score: 48.08  E-value: 7.63e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 4885629     82 VMEVSDRRNCGYPGISPEECASRKCCF-SNFIFEVPWCFFP 121
Cdd:pfam00088   3 SVPPSDRFDCGYPGITQEECEARGCCWdPSVDPGVPWCFYP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH