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Conserved domains on  [gi|5031707|ref|NP_005503|]
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transforming growth factor beta activator LRRC32 isoform a precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-277 3.55e-42

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


:

Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 155.21  E-value: 3.55e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   19 QHQDKVPCkMVDKKVSCQVLG---LLQVPSVL--PPDTETLDLSGNQLRSI---LASPLGFYTA---LRHLDLSTNEISF 87
Cdd:cd00116  17 ELLPKLLC-LQVLRLEGNTLGeeaAKALASALrpQPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGP 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   88 LQPGAFQALTH---LEHLSLAHNRLA-MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAEN 159
Cdd:cd00116  96 DGCGVLESLLRsssLQELKLNNNGLGdRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANN 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  160 SLT-RLTRHTFRDMPA---LEQLDLHSNVLMDIEDGAFEGLPR----LTHLNLSRNSLT--CISDFSLQ------QLRVL 223
Cdd:cd00116 176 GIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAETLAslksLEVLNLGDNNLTdaGAAALASAllspniSLLTL 255

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5031707  224 DLSCNSIE--AFQTASQPQAEF-QLTWLDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 277
Cdd:cd00116 256 SLSCNDITddGAKDLAEVLAEKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-574 5.24e-19

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 5.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  290 IHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 369
Cdd:COG4886  23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  370 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLS 449
Cdd:COG4886 103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLT-----DLPEP-----LGNLTNLKSLD 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  450 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALGGLEaSLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL 529
Cdd:COG4886 166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 5031707  530 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 574
Cdd:COG4886 244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
PLN03150 super family cl31977
hypothetical protein; Provisional
 496-654 3.08e-04

hypothetical protein; Provisional


The actual alignment was detected with superfamily member PLN03150:

Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   496 LALQGNGLM-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 571
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   572 PLSCCGNGWLAAQ-LHQGRVDVDATQDLiCrfssqeevSLSHVRPedCekGGLKNINLIIILTF-ILVSAILLTTLAACC 649
Cdd:PLN03150 501 SLSGRVPAALGGRlLHRASFNFTDNAGL-C--------GIPGLRA--C--GPHLSVGAKIGIAFgVSVAFLFLVICAMCW 567


                 ....*
gi 5031707   650 CVRRQ 654
Cdd:PLN03150 568 WKRRQ 572
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-277 3.55e-42

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 155.21  E-value: 3.55e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   19 QHQDKVPCkMVDKKVSCQVLG---LLQVPSVL--PPDTETLDLSGNQLRSI---LASPLGFYTA---LRHLDLSTNEISF 87
Cdd:cd00116  17 ELLPKLLC-LQVLRLEGNTLGeeaAKALASALrpQPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGP 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   88 LQPGAFQALTH---LEHLSLAHNRLA-MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAEN 159
Cdd:cd00116  96 DGCGVLESLLRsssLQELKLNNNGLGdRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANN 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  160 SLT-RLTRHTFRDMPA---LEQLDLHSNVLMDIEDGAFEGLPR----LTHLNLSRNSLT--CISDFSLQ------QLRVL 223
Cdd:cd00116 176 GIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAETLAslksLEVLNLGDNNLTdaGAAALASAllspniSLLTL 255

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5031707  224 DLSCNSIE--AFQTASQPQAEF-QLTWLDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 277
Cdd:cd00116 256 SLSCNDITddGAKDLAEVLAEKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-278 3.13e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 3.13e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   36 QVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRlamatal 115
Cdd:COG4886  35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  116 sagGLGPLPRVTSLDLSGNSLYSglLERLLGEAPSLHTLSLAENSLTRLTRhTFRDMPALEQLDLHSNVLMDIeDGAFEG 195
Cdd:COG4886 108 ---ELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGN 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  196 LPRLTHLNLSRNSLTCISD--FSLQQLRVLDLSCNSIEAFqtaSQPQAEF-QLTWLDLRENKLLHFPDLAALPRLIYLNL 272
Cdd:COG4886 181 LTNLKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDL 257


                ....*.
gi 5031707  273 SNNLIR 278
Cdd:COG4886 258 SNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-574 5.24e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 5.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  290 IHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 369
Cdd:COG4886  23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  370 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLS 449
Cdd:COG4886 103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLT-----DLPEP-----LGNLTNLKSLD 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  450 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALGGLEaSLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL 529
Cdd:COG4886 166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 5031707  530 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 574
Cdd:COG4886 244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-495 1.39e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.13  E-value: 1.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707    43 VPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLamaTALSAGGLGP 122
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQ 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   123 LPRVTSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHL 202
Cdd:PLN00113 211 MKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISL 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   203 NLSRNSLTC-ISDF--SLQQLRVLDLSCNSIeafqTASQPQAefqltwldlrenkllhfpdLAALPRLIYLNLSNNliRL 279
Cdd:PLN00113 290 DLSDNSLSGeIPELviQLQNLEILHLFSNNF----TGKIPVA-------------------LTSLPRLQVLQLWSN--KF 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   280 PTGPPQDsKGIHapsEGWSALPLSapSGNASGR-PLS-----QLLNLDLSYNEIE-LIPDSfLEHLTSLCFLNLSRNCLR 352
Cdd:PLN00113 345 SGEIPKN-LGKH---NNLTVLDLS--TNNLTGEiPEGlcssgNLFKLILFSNSLEgEIPKS-LGACRSLRRVRLQDNSFS 417

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   353 TFEARRLGSLPCLMLLDLSHN--------------ALETLELGARAL--------GS--LRTLLLQGNALRDLPPYTFAN 408
Cdd:PLN00113 418 GELPSEFTKLPLVYFLDISNNnlqgrinsrkwdmpSLQMLSLARNKFfgglpdsfGSkrLENLDLSRNQFSGAVPRKLGS 497

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   409 LASLQRLNLQGNRVSpcgG--PDEpgpsgcvaFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGA 485
Cdd:PLN00113 498 LSELMQLKLSENKLS---GeiPDE--------LSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQNQLSGEIPKN 566

                        490
                 ....*....|
gi 5031707   486 LGGLEASLEV 495
Cdd:PLN00113 567 LGNVESLVQV 576
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 198-423 5.71e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.66  E-value: 5.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  198 RLTHLNLSRNSLTCISDFSL-QQLRVLDLSCN---SIEAFQTASQpqaefqLTWLDLRENKLLHFPDLAALPRLIYLNLS 273
Cdd:cd21340   3 RITHLYLNDKNITKIDNLSLcKNLKVLYLYDNkitKIENLEFLTN------LTHLYLQNNQIEKIENLENLVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  274 NNLIRLPTGppqdskgihapsegwsalplsapsgnasgrplsqllnldlsyneielipdsfLEHLTSLCFLNLSRNCLR- 352
Cdd:cd21340  77 GNRISVVEG----------------------------------------------------LENLTNLEELHIENQRLPp 104

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5031707  353 ----TFEARRLGSL-PCLMLLDLSHNALETLElGARALGSLRTLLLQGNALRDLPP--YTFANLASLQRLNLQGNRVS 423
Cdd:cd21340 105 geklTFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-574 1.59e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 1.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707    49 PDTETLDLSGNQLRSILASPLgFYT--ALRHLDLSTNEISFLQPGAFqaLTHLEHLSLAHNrlaMATALSAGGLGPLPRV 126
Cdd:PLN00113  93 PYIQTINLSNNQLSGPIPDDI-FTTssSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNN---MLSGEIPNDIGSFSSL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   127 TSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSR 206
Cdd:PLN00113 167 KVLDLGGNVL-VGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVY 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   207 NSLTCISDFSLQQLRvldlscnsieafqtasqpqaefQLTWLDLRENKLLHF--PDLAALPRLIYLNLSNNLIrlptgpp 284
Cdd:PLN00113 246 NNLTGPIPSSLGNLK----------------------NLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSL------- 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   285 qdskgihapsegwsalplsapSGNASgRPLSQLLNLDL----SYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEARRLG 360
Cdd:PLN00113 297 ---------------------SGEIP-ELVIQLQNLEIlhlfSNNFTGKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLG 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   361 SLPCLMLLDLSHNALE-TLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNrvspcggpdepgpsgcvAF 439
Cdd:PLN00113 354 KHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN-----------------SF 416

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   440 SGitslrslslvdneiELLRAgaFLHTPLTE-LDLSSNpglevatgalggleaslevlALQGNgLMVLQVDLPCficLKR 518
Cdd:PLN00113 417 SG--------------ELPSE--FTKLPLVYfLDISNN--------------------NLQGR-INSRKWDMPS---LQM 456

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031707   519 LNLAENRLS-HLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLeTSLRRLYLQGNPLS 574
Cdd:PLN00113 457 LSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSL-SELMQLKLSENKLS 512
LRR_8 pfam13855
Leucine rich repeat;
149-209 4.79e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 4.79e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5031707    149 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL 209
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
315-375 8.48e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 8.48e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5031707    315 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNAL 375
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-52 1.28e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.30  E-value: 1.28e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 5031707      21 QDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTE 52
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PLN03150 PLN03150
hypothetical protein; Provisional
 496-654 3.08e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   496 LALQGNGLM-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 571
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   572 PLSCCGNGWLAAQ-LHQGRVDVDATQDLiCrfssqeevSLSHVRPedCekGGLKNINLIIILTF-ILVSAILLTTLAACC 649
Cdd:PLN03150 501 SLSGRVPAALGGRlLHRASFNFTDNAGL-C--------GIPGLRA--C--GPHLSVGAKIGIAFgVSVAFLFLVICAMCW 567


                 ....*
gi 5031707   650 CVRRQ 654
Cdd:PLN03150 568 WKRRQ 572
 
Name Accession Description Interval E-value
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 19-277 3.55e-42

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 155.21  E-value: 3.55e-42
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   19 QHQDKVPCkMVDKKVSCQVLG---LLQVPSVL--PPDTETLDLSGNQLRSI---LASPLGFYTA---LRHLDLSTNEISF 87
Cdd:cd00116  17 ELLPKLLC-LQVLRLEGNTLGeeaAKALASALrpQPSLKELCLSLNETGRIprgLQSLLQGLTKgcgLQELDLSDNALGP 95

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   88 LQPGAFQALTH---LEHLSLAHNRLA-MATALSAGGLGPL-PRVTSLDLSGNSLYSGLLERLLGEAP---SLHTLSLAEN 159
Cdd:cd00116  96 DGCGVLESLLRsssLQELKLNNNGLGdRGLRLLAKGLKDLpPALEKLVLGRNRLEGASCEALAKALRanrDLKELNLANN 175

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  160 SLT-RLTRHTFRDMPA---LEQLDLHSNVLMDIEDGAFEGLPR----LTHLNLSRNSLT--CISDFSLQ------QLRVL 223
Cdd:cd00116 176 GIGdAGIRALAEGLKAncnLEVLDLNNNGLTDEGASALAETLAslksLEVLNLGDNNLTdaGAAALASAllspniSLLTL 255

                       250       260       270       280       290       300
                ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 5031707  224 DLSCNSIE--AFQTASQPQAEF-QLTWLDLRENKL------LHFPDLAAL-PRLIYLNLSNNLI 277
Cdd:cd00116 256 SLSCNDITddGAKDLAEVLAEKeSLLELDLRGNKFgeegaqLLAESLLEPgNELESLWVKDDSF 319
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
36-278 3.13e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 90.76  E-value: 3.13e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   36 QVLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRlamatal 115
Cdd:COG4886  35 LALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE------- 107

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  116 sagGLGPLPRVTSLDLSGNSLYSglLERLLGEAPSLHTLSLAENSLTRLTRhTFRDMPALEQLDLHSNVLMDIeDGAFEG 195
Cdd:COG4886 108 ---ELSNLTNLESLDLSGNQLTD--LPEELANLTNLKELDLSNNQLTDLPE-PLGNLTNLKSLDLSNNQLTDL-PEELGN 180

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  196 LPRLTHLNLSRNSLTCISD--FSLQQLRVLDLSCNSIEAFqtaSQPQAEF-QLTWLDLRENKLLHFPDLAALPRLIYLNL 272
Cdd:COG4886 181 LTNLKELDLSNNQITDLPEplGNLTNLEELDLSGNQLTDL---PEPLANLtNLETLDLSNNQLTDLPELGNLTNLEELDL 257


                ....*.
gi 5031707  273 SNNLIR 278
Cdd:COG4886 258 SNNQLT 263
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
290-574 5.24e-19

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 89.99  E-value: 5.24e-19
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  290 IHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLD 369
Cdd:COG4886  23 TLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELD 102

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  370 LSHNALETlelgarALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLS 449
Cdd:COG4886 103 LSGNEELS------NLTNLESLDLSGNQLTDLPE-ELANLTNLKELDLSNNQLT-----DLPEP-----LGNLTNLKSLD 165

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  450 LVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATGALGGLEaSLEVLALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL 529
Cdd:COG4886 166 LSNNQLTDLPEELGNLTNLKELDLSNNQ-ITDLPEPLGNLT-NLEELDLSGNQLTDLPEPLANLTNLETLDLSNNQLTDL 243

                       250       260       270       280
                ....*....|....*....|....*....|....*....|....*
gi 5031707  530 PAWTQAVSLEVLDLRNNSFSLLPGSamGGLeTSLRRLYLQGNPLS 574
Cdd:COG4886 244 PELGNLTNLEELDLSNNQLTDLPPL--ANL-TNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
37-393 1.45e-18

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 88.45  E-value: 1.45e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   37 VLGLLQVPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALS 116
Cdd:COG4886   9 TLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLG 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  117 AGGLGPLPRVTSLDLSGNslysglleRLLGEAPSLHTLSLAENSLTRLTRHtFRDMPALEQLDLHSNVLMDIEDgAFEGL 196
Cdd:COG4886  89 LTDLGDLTNLTELDLSGN--------EELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPE-PLGNL 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  197 PRLTHLNLSRNSLTCISDF--SLQQLRVLDLSCNSIEAFQTA-SQPQaefQLTWLDLRENKLLHFPD-LAALPRLIYLNL 272
Cdd:COG4886 159 TNLKSLDLSNNQLTDLPEElgNLTNLKELDLSNNQITDLPEPlGNLT---NLEELDLSGNQLTDLPEpLANLTNLETLDL 235

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  273 SNNLIrlptgppqdskgihapsegwSALP-LSApsgnasgrpLSQLLNLDLSYNEIELIPDSFleHLTSLCFLNLSRNCL 351
Cdd:COG4886 236 SNNQL--------------------TDLPeLGN---------LTNLEELDLSNNQLTDLPPLA--NLTNLKTLDLSNNQL 284

                       330       340       350       360
                ....*....|....*....|....*....|....*....|..
gi 5031707  352 RTFEARRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLL 393
Cdd:COG4886 285 TDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLL 326
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
128-423 2.27e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 84.99  E-value: 2.27e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  128 SLDLSGNSLYSGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRN 207
Cdd:COG4886  27 LLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN 106

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  208 SLTcisdFSLQQLRVLDLSCNSIEAFQTA-SQPQaefQLTWLDLRENKLLHFPD-LAALPRLIYLNLSNNLIrlptgppq 285
Cdd:COG4886 107 EEL----SNLTNLESLDLSGNQLTDLPEElANLT---NLKELDLSNNQLTDLPEpLGNLTNLKSLDLSNNQL-------- 171

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  286 dskgihapsegwSALPlsapsgnASGRPLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEArRLGSLPCL 365
Cdd:COG4886 172 ------------TDLP-------EELGNLTNLKELDLSNNQITDLPEP-LGNLTNLEELDLSGNQLTDLPE-PLANLTNL 230

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 5031707  366 MLLDLSHNALETL-ELGarALGSLRTLLLQGNALRDLPPytFANLASLQRLNLQGNRVS 423
Cdd:COG4886 231 ETLDLSNNQLTDLpELG--NLTNLEELDLSNNQLTDLPP--LANLTNLKTLDLSNNQLT 285
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
245-551 6.07e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 83.44  E-value: 6.07e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  245 LTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPSGNASGRPLSQLLNLDLSY 324
Cdd:COG4886   2 LLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLL 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  325 NEIELIPDSFLEHLTSLCFLNLSRNclrtfeaRRLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPy 404
Cdd:COG4886  82 LSLLLLGLTDLGDLTNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEELANLTNLKELDLSNNQLTDLPE- 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  405 TFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSGITSLRSLSLVDNEIELLRAGAFLHTPLTELDLSSNPgLEVATG 484
Cdd:COG4886 154 PLGNLTNLKSLDLSNNQLT-----DLPEE-----LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQ-LTDLPE 222

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  485 ALGGLEaSLEVLALQGNGLmvlqVDLPCFIC---LKRLNLAENRLSHLPAWTQAVSLEVLDLRNNSFSLL 551
Cdd:COG4886 223 PLANLT-NLETLDLSNNQL----TDLPELGNltnLEELDLSNNQLTDLPPLANLTNLKTLDLSNNQLTDL 287
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 43-495 1.39e-16

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 84.13  E-value: 1.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707    43 VPSVLPPDTETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLamaTALSAGGLGP 122
Cdd:PLN00113 134 IPRGSIPNLETLDLSNNMLSGEIPNDIGSFSSLKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQL---VGQIPRELGQ 210

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   123 LPRVTSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHL 202
Cdd:PLN00113 211 MKSLKWIYLGYNNL-SGEIPYEIGGLTSLNHLDLVYNNLTGPIPSSLGNLKNLQYLFLYQNKLSGPIPPSIFSLQKLISL 289

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   203 NLSRNSLTC-ISDF--SLQQLRVLDLSCNSIeafqTASQPQAefqltwldlrenkllhfpdLAALPRLIYLNLSNNliRL 279
Cdd:PLN00113 290 DLSDNSLSGeIPELviQLQNLEILHLFSNNF----TGKIPVA-------------------LTSLPRLQVLQLWSN--KF 344

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   280 PTGPPQDsKGIHapsEGWSALPLSapSGNASGR-PLS-----QLLNLDLSYNEIE-LIPDSfLEHLTSLCFLNLSRNCLR 352
Cdd:PLN00113 345 SGEIPKN-LGKH---NNLTVLDLS--TNNLTGEiPEGlcssgNLFKLILFSNSLEgEIPKS-LGACRSLRRVRLQDNSFS 417

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   353 TFEARRLGSLPCLMLLDLSHN--------------ALETLELGARAL--------GS--LRTLLLQGNALRDLPPYTFAN 408
Cdd:PLN00113 418 GELPSEFTKLPLVYFLDISNNnlqgrinsrkwdmpSLQMLSLARNKFfgglpdsfGSkrLENLDLSRNQFSGAVPRKLGS 497

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   409 LASLQRLNLQGNRVSpcgG--PDEpgpsgcvaFSGITSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGA 485
Cdd:PLN00113 498 LSELMQLKLSENKLS---GeiPDE--------LSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQNQLSGEIPKN 566

                        490
                 ....*....|
gi 5031707   486 LGGLEASLEV 495
Cdd:PLN00113 567 LGNVESLVQV 576
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
195-529 3.98e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 78.05  E-value: 3.98e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  195 GLPRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKllhfpDLAALPRLIYLNLSN 274
Cdd:COG4886  48 LLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNE-----ELSNLTNLESLDLSG 122

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  275 NLIrlptgppqdskgihapsegwSALPLSAPSgnasgrpLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTF 354
Cdd:COG4886 123 NQL--------------------TDLPEELAN-------LTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLSNNQLTDL 174

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  355 EARrLGSLPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPgps 434
Cdd:COG4886 175 PEE-LGNLTNLKELDLSNNQITDLPEPLGNLTNLEELDLSGNQLTDLPE-PLANLTNLETLDLSNNQLT-----DLP--- 244

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  435 gcvAFSGITSLRSLSLVDNEIELLRAGAFLhTPLTELDLSSNP--GLEVATGALGGLEASLEVLALQGNGLMVLQVDLPC 512
Cdd:COG4886 245 ---ELGNLTNLEELDLSNNQLTDLPPLANL-TNLKTLDLSNNQltDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLL 320

                       330
                ....*....|....*..
gi 5031707  513 FICLKRLNLAENRLSHL 529
Cdd:COG4886 321 TTLLLLLLLLKGLLVTL 337
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
202-551 2.25e-13

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 72.66  E-value: 2.25e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  202 LNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPQAEFQLTWLDLRENKLLHFPDLAALPRLIYLNLSNNLIRLPT 281
Cdd:COG4886   3 LLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLL 82

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  282 GPPQDSKGIHAPSEGWSALPLSapsGNASGRPLSQLLNLDLSYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEARrLGS 361
Cdd:COG4886  83 SLLLLGLTDLGDLTNLTELDLS---GNEELSNLTNLESLDLSGNQLTDLPEE-LANLTNLKELDLSNNQLTDLPEP-LGN 157

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  362 LPCLMLLDLSHNALETLELGARALGSLRTLLLQGNALRDLPPyTFANLASLQRLNLQGNRVSpcggpDEPGPsgcvaFSG 441
Cdd:COG4886 158 LTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQITDLPE-PLGNLTNLEELDLSGNQLT-----DLPEP-----LAN 226

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  442 ITSLRSLSLVDNEIELLRAGAFLhTPLTELDLSSNPglevatgaLGGLEASLEVLALQgnglmvlqvdlpcficlkRLNL 521
Cdd:COG4886 227 LTNLETLDLSNNQLTDLPELGNL-TNLEELDLSNNQ--------LTDLPPLANLTNLK------------------TLDL 279

                       330       340       350
                ....*....|....*....|....*....|
gi 5031707  522 AENRLSHLPAWTQAVSLEVLDLRNNSFSLL 551
Cdd:COG4886 280 SNNQLTDLKLKELELLLGLNSLLLLLLLLN 309
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
119-422 5.04e-13

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 72.42  E-value: 5.04e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   119 GLGPLP-----RVTSLDLSGNSLYSgLLERLLGeapSLHTLSLAENSLTRLTRhTFRDmpALEQLDLHSNVLMDIEdgaf 193
Cdd:PRK15370 189 GLTTIPacipeQITTLILDNNELKS-LPENLQG---NIKTLYANSNQLTSIPA-TLPD--TIQEMELSINRITELP---- 257

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   194 EGLPR-LTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFqtasqPQaefqltwldlrenkllHFPDlaalpRLIYLNL 272
Cdd:PRK15370 258 ERLPSaLQSLDLFHNKISCLPENLPEELRYLSVYDNSIRTL-----PA----------------HLPS-----GITHLNV 311

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   273 -SNNLIRLPTGPPQDSKGIHAPSEGWSALPLSAPsgnasgrplSQLLNLDLSYNEIELIPDSFLEHLTSlcfLNLSRNCL 351
Cdd:PRK15370 312 qSNSLTALPETLPPGLKTLEAGENALTSLPASLP---------PELQVLDVSKNQITVLPETLPPTITT---LDVSRNAL 379

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   352 RTFEArrlgSLP-CLMLLDLSHNALetlelgARALGSLRTLLLQG----NALRDLPPYTFANLASLQRL----NLQGNRV 422
Cdd:PRK15370 380 TNLPE----NLPaALQIMQASRNNL------VRLPESLPHFRGEGpqptRIIVEYNPFSERTIQNMQRLmssvGYQGPRV 449
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 198-423 5.71e-13

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 68.66  E-value: 5.71e-13
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  198 RLTHLNLSRNSLTCISDFSL-QQLRVLDLSCN---SIEAFQTASQpqaefqLTWLDLRENKLLHFPDLAALPRLIYLNLS 273
Cdd:cd21340   3 RITHLYLNDKNITKIDNLSLcKNLKVLYLYDNkitKIENLEFLTN------LTHLYLQNNQIEKIENLENLVNLKKLYLG 76

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  274 NNLIRLPTGppqdskgihapsegwsalplsapsgnasgrplsqllnldlsyneielipdsfLEHLTSLCFLNLSRNCLR- 352
Cdd:cd21340  77 GNRISVVEG----------------------------------------------------LENLTNLEELHIENQRLPp 104

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 5031707  353 ----TFEARRLGSL-PCLMLLDLSHNALETLElGARALGSLRTLLLQGNALRDLPP--YTFANLASLQRLNLQGNRVS 423
Cdd:cd21340 105 geklTFDPRSLAALsNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDLTGNPVC 181
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 49-574 1.59e-12

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 71.03  E-value: 1.59e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707    49 PDTETLDLSGNQLRSILASPLgFYT--ALRHLDLSTNEISFLQPGAFqaLTHLEHLSLAHNrlaMATALSAGGLGPLPRV 126
Cdd:PLN00113  93 PYIQTINLSNNQLSGPIPDDI-FTTssSLRYLNLSNNNFTGSIPRGS--IPNLETLDLSNN---MLSGEIPNDIGSFSSL 166

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   127 TSLDLSGNSLySGLLERLLGEAPSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSR 206
Cdd:PLN00113 167 KVLDLGGNVL-VGKIPNSLTNLTSLEFLTLASNQLVGQIPRELGQMKSLKWIYLGYNNLSGEIPYEIGGLTSLNHLDLVY 245

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   207 NSLTCISDFSLQQLRvldlscnsieafqtasqpqaefQLTWLDLRENKLLHF--PDLAALPRLIYLNLSNNLIrlptgpp 284
Cdd:PLN00113 246 NNLTGPIPSSLGNLK----------------------NLQYLFLYQNKLSGPipPSIFSLQKLISLDLSDNSL------- 296

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   285 qdskgihapsegwsalplsapSGNASgRPLSQLLNLDL----SYNEIELIPDSfLEHLTSLCFLNLSRNCLRTFEARRLG 360
Cdd:PLN00113 297 ---------------------SGEIP-ELVIQLQNLEIlhlfSNNFTGKIPVA-LTSLPRLQVLQLWSNKFSGEIPKNLG 353

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   361 SLPCLMLLDLSHNALE-TLELGARALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNrvspcggpdepgpsgcvAF 439
Cdd:PLN00113 354 KHNNLTVLDLSTNNLTgEIPEGLCSSGNLFKLILFSNSLEGEIPKSLGACRSLRRVRLQDN-----------------SF 416

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   440 SGitslrslslvdneiELLRAgaFLHTPLTE-LDLSSNpglevatgalggleaslevlALQGNgLMVLQVDLPCficLKR 518
Cdd:PLN00113 417 SG--------------ELPSE--FTKLPLVYfLDISNN--------------------NLQGR-INSRKWDMPS---LQM 456

                        490       500       510       520       530
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 5031707   519 LNLAENRLS-HLPAWTQAVSLEVLDLRNNSFSLLPGSAMGGLeTSLRRLYLQGNPLS 574
Cdd:PLN00113 457 LSLARNKFFgGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSL-SELMQLKLSENKLS 512
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
36-296 1.89e-12

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 70.50  E-value: 1.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707    36 QVLGLLQVPSVLPPDTETLDLSGNQLRSIlasPLGFYTALRHLDLSTNEISFLqPGAFQalTHLEHLSLAHNRLamaTAL 115
Cdd:PRK15370 186 KILGLTTIPACIPEQITTLILDNNELKSL---PENLQGNIKTLYANSNQLTSI-PATLP--DTIQEMELSINRI---TEL 256

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   116 SAgglgPLPR-VTSLDLSGNSLySGLLERLLGEapsLHTLSLAENSLTRLTRHtfrdMPA-LEQLDLHSNVLMDIEdgaf 193
Cdd:PRK15370 257 PE----RLPSaLQSLDLFHNKI-SCLPENLPEE---LRYLSVYDNSIRTLPAH----LPSgITHLNVQSNSLTALP---- 320

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   194 EGLP-RLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSIEAFQTASQPqaefQLTWLDLRENKLLHFPDlaALP-RLIYLN 271
Cdd:PRK15370 321 ETLPpGLKTLEAGENALTSLPASLPPELQVLDVSKNQITVLPETLPP----TITTLDVSRNALTNLPE--NLPaALQIMQ 394

                        250       260
                 ....*....|....*....|....*.
gi 5031707   272 LS-NNLIRLPTGPPqdskgiHAPSEG 296
Cdd:PRK15370 395 ASrNNLVRLPESLP------HFRGEG 414
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 52-210 3.47e-12

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 66.35  E-value: 3.47e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   52 ETLDLSGNQLRSIlaSPLGFYTALRHLDLSTNEISFLQPgaFQALTHLEHLSLAHNRLAMATalsagGLGPLPRVTSLDL 131
Cdd:cd21340  27 KVLYLYDNKITKI--ENLEFLTNLTHLYLQNNQIEKIEN--LENLVNLKKLYLGGNRISVVE-----GLENLTNLEELHI 97

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  132 SGNSLYSGLL-----ERLLGEAPSLHTLSLAENSLTRLTrhTFRDMPALEQLDLHSNVLMDIED--GAFEGLPRLTHLNL 204
Cdd:cd21340  98 ENQRLPPGEKltfdpRSLAALSNSLRVLNISGNNIDSLE--PLAPLRNLEQLDASNNQISDLEEllDLLSSWPSLRELDL 175


                ....*.
gi 5031707  205 SRNSLT 210
Cdd:cd21340 176 TGNPVC 181
LRR_8 pfam13855
Leucine rich repeat;
149-209 4.79e-12

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 61.39  E-value: 4.79e-12
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5031707    149 PSLHTLSLAENSLTRLTRHTFRDMPALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSL 209
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-253 1.12e-11

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 64.81  E-value: 1.12e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   54 LDLSGNQLRSIlaSPLGFYTALRHLDLSTNEISFLQpgAFQALTHLEHLSLAHNRLamataLSAGGLGPLPRVTSLDLSG 133
Cdd:cd21340   7 LYLNDKNITKI--DNLSLCKNLKVLYLYDNKITKIE--NLEFLTNLTHLYLQNNQI-----EKIENLENLVNLKKLYLGG 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  134 NSLysgllERLLGeapsLHTLSlaenSLTRLTrhtfrdmpaLEQLDLHSNVLMDIEDGAFEGL-PRLTHLNLSRNSLTCI 212
Cdd:cd21340  78 NRI-----SVVEG----LENLT----NLEELH---------IENQRLPPGEKLTFDPRSLAALsNSLRVLNISGNNIDSL 135

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 5031707  213 SDFS-LQQLRVLDLSCNSIEAFQTASQP-QAEFQLTWLDLREN 253
Cdd:cd21340 136 EPLApLRNLEQLDASNNQISDLEELLDLlSSWPSLRELDLTGN 178
LRR_8 pfam13855
Leucine rich repeat;
75-136 3.45e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 53.30  E-value: 3.45e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 5031707     75 LRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLamaTALSAGGLGPLPRVTSLDLSGNSL 136
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLL---TTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 53-232 6.52e-09

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 58.65  E-value: 6.52e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   53 TLDLSGNQL----RSILASPLGFYTALRHLDLSTNEISflQPGA---FQALTH---LEHLSLAHNRLAMATALS-AGGLG 121
Cdd:COG5238 212 TLWLKRNPIgdegAEILAEALKGNKSLTTLDLSNNQIG--DEGVialAEALKNnttVETLYLSGNQIGAEGAIAlAKALQ 289

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  122 PLPRVTSLDLSGNSL----YSGLLERLLGEAPsLHTLSLAENSLT----RLTRHTFRDMPALEQLDLHSNVLMDIEDGAF 193
Cdd:COG5238 290 GNTTLTSLDLSVNRIgdegAIALAEGLQGNKT-LHTLNLAYNGIGaqgaIALAKALQENTTLHSLDLSDNQIGDEGAIAL 368

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*....
gi 5031707  194 ----EGLPRLTHLNLSRNSLT------CISDFSLQQLRVLDLSCNSIEA 232
Cdd:COG5238 369 akylEGNTTLRELNLGKNNIGkqgaeaLIDALQTNRLHTLILDGNLIGA 417
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 150-396 7.08e-09

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 56.33  E-value: 7.08e-09
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  150 SLHTLSLAENSLTRLTRhtFRDMPALEQLDLHSNVLMDIEDgaFEGLPRLTHLNLSRNSLTCISDF-SLQQLRVLDLSCN 228
Cdd:cd21340   3 RITHLYLNDKNITKIDN--LSLCKNLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIENLeNLVNLKKLYLGGN 78

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  229 SIEAFqtasqpqaefqltwldlrENkllhfpdLAALPRLIYLNLSNNliRLPTGppqdskgihapsegwsalplsapsgn 308
Cdd:cd21340  79 RISVV------------------EG-------LENLTNLEELHIENQ--RLPPG-------------------------- 105

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  309 asgrplsqllnldlsyNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEArrLGSLPCLMLLDLSHNAL---ETLELGARAL 385
Cdd:cd21340 106 ----------------EKLTFDPRSLAALSNSLRVLNISGNNIDSLEP--LAPLRNLEQLDASNNQIsdlEELLDLLSSW 167

                       250
                ....*....|.
gi 5031707  386 GSLRTLLLQGN 396
Cdd:cd21340 168 PSLRELDLTGN 178
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
31-230 1.44e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 58.17  E-value: 1.44e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707    31 KKVSCQVLGLLQVPSVLPPDTETLDLSGNQlrsILASPLGFYTALRHLDLSTNEISFLqPGAFQalTHLEHLSLAHNRLa 110
Cdd:PRK15370 223 KTLYANSNQLTSIPATLPDTIQEMELSINR---ITELPERLPSALQSLDLFHNKISCL-PENLP--EELRYLSVYDNSI- 295

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   111 maTALSAGglgpLPR-VTSLDLSGNSLySGLLERLlgeAPSLHTLSLAENSLTRLTRHTfrdMPALEQLDLHSNVLMDIE 189
Cdd:PRK15370 296 --RTLPAH----LPSgITHLNVQSNSL-TALPETL---PPGLKTLEAGENALTSLPASL---PPELQVLDVSKNQITVLP 362

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 5031707   190 dgafEGL-PRLTHLNLSRNSLTCISDFSLQQLRVLDLSCNSI 230
Cdd:PRK15370 363 ----ETLpPTITTLDVSRNALTNLPENLPAALQIMQASRNNL 400
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 314-477 4.71e-08

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 54.02  E-value: 4.71e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  314 LSQLLNLDLSY---NEIELIPDsfLEHLTSLCFLNLSRNCLRTFEarRLGSLPCLMLLDLSHNALETLElGARALGSLRT 390
Cdd:cd21340  20 LSLCKNLKVLYlydNKITKIEN--LEFLTNLTHLYLQNNQIEKIE--NLENLVNLKKLYLGGNRISVVE-GLENLTNLEE 94

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  391 LLLQGNALRDLPPYTF-----ANLA-SLQRLNLQGNRVspcggpDEPGPsgcvaFSGITSLRSLSLVDNEIELLR--AGA 462
Cdd:cd21340  95 LHIENQRLPPGEKLTFdprslAALSnSLRVLNISGNNI------DSLEP-----LAPLRNLEQLDASNNQISDLEelLDL 163

                       170
                ....*....|....*.
gi 5031707  463 FLHTP-LTELDLSSNP 477
Cdd:cd21340 164 LSSWPsLRELDLTGNP 179
LRR_8 pfam13855
Leucine rich repeat;
173-230 7.25e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.45  E-value: 7.25e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5031707    173 PALEQLDLHSNVLMDIEDGAFEGLPRLTHLNLSRNSLTCISDFSLQ---QLRVLDLSCNSI 230
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSglpSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
315-375 8.48e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 49.06  E-value: 8.48e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5031707    315 SQLLNLDLSYNEIELIPDSFLEHLTSLCFLNLSRNCLRTFEARRLGSLPCLMLLDLSHNAL 375
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 387-552 1.15e-07

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 52.87  E-value: 1.15e-07
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  387 SLRTLLLQGNALRDLPPytFANLASLQRLNLQGNRVSPCGGpdepgpsgcvaFSGITSLRSLSLVDNEIELLrAGafLH- 465
Cdd:cd21340  25 NLKVLYLYDNKITKIEN--LEFLTNLTHLYLQNNQIEKIEN-----------LENLVNLKKLYLGGNRISVV-EG--LEn 88

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  466 -TPLTELDLS-----SNPGLEVATGALGGLEASLEVLALQGNGLMVLQvDLPCFICLKRLNLAENRLSHLPAWTQAVS-- 537
Cdd:cd21340  89 lTNLEELHIEnqrlpPGEKLTFDPRSLAALSNSLRVLNISGNNIDSLE-PLAPLRNLEQLDASNNQISDLEELLDLLSsw 167

                       170
                ....*....|....*..
gi 5031707  538 --LEVLDLRNNSFSLLP 552
Cdd:cd21340 168 psLRELDLTGNPVCKKP 184
LRR_8 pfam13855
Leucine rich repeat;
52-109 2.24e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 47.90  E-value: 2.24e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 5031707     52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRL 109
Cdd:pfam13855   4 RSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
297-573 2.52e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.93  E-value: 2.52e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   297 WSALPLSAPSGNASGRPLS-QLLNLDLSYNEIEL---------IPDSFLEHLTSLCF-----LNLSRNC---LRTFEAR- 357
Cdd:PRK15370 150 WSEWVKEAPAKEAANREEAvQRMRDCLKNNKTELrlkilglttIPACIPEQITTLILdnnelKSLPENLqgnIKTLYANs 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   358 -RLGSLP-----CLMLLDLSHNALetLELGARALGSLRTLLLQGNALRDLPPytfanlaslqrlNLqgnrvspcggPDEp 431
Cdd:PRK15370 230 nQLTSIPatlpdTIQEMELSINRI--TELPERLPSALQSLDLFHNKISCLPE------------NL----------PEE- 284

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   432 gpsgcvafsgitsLRSLSLVDNEIELLRAgaflHTPlteldlssnpglevatgalggleASLEVLALQGNGLMVLQVDLP 511
Cdd:PRK15370 285 -------------LRYLSVYDNSIRTLPA----HLP-----------------------SGITHLNVQSNSLTALPETLP 324

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 5031707   512 cfICLKRLNLAENRLSHLPAwTQAVSLEVLDLRNNSFSLLPGSamggLETSLRRLYLQGNPL 573
Cdd:PRK15370 325 --PGLKTLEAGENALTSLPA-SLPPELQVLDVSKNQITVLPET----LPPTITTLDVSRNAL 379
PRK15387 PRK15387
type III secretion system effector E3 ubiquitin transferase SspH2;
39-363 5.39e-07

type III secretion system effector E3 ubiquitin transferase SspH2;


Pssm-ID: 185285 [Multi-domain]  Cd Length: 788  Bit Score: 52.86  E-value: 5.39e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707    39 GLLQVPSVLPPDTETLDLSGNQLRSILASPlgfyTALRHLDLSTNEIS---FLQPGafqalthLEHLSLAHNRLAMATAL 115
Cdd:PRK15387 212 GLTTLPDCLPAHITTLVIPDNNLTSLPALP----PELRTLEVSGNQLTslpVLPPG-------LLELSIFSNPLTHLPAL 280

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   116 SAGglgplprVTSLDLSGNSLYSgllerLLGEAPSLHTLSLAENSLTRLtrhtfrdmPALEQldlhsnvlmdiedgafeg 195
Cdd:PRK15387 281 PSG-------LCKLWIFGNQLTS-----LPVLPPGLQELSVSDNQLASL--------PALPS------------------ 322

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   196 lpRLTHLNLSRNSLTCISDF--SLQQLRVLDlscnsieaFQTASQPQAEFQLTWLDLRENKLLHFPDL-AALPRLIYlnL 272
Cdd:PRK15387 323 --ELCKLWAYNNQLTSLPTLpsGLQELSVSD--------NQLASLPTLPSELYKLWAYNNRLTSLPALpSGLKELIV--S 390

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   273 SNNLIRLPTgPPQDSKGIHAPSEGWSALPLsAPSGnasgrplsqLLNLDLSYNEIELIPDSFLeHLTSLCFLNLSRNCL- 351
Cdd:PRK15387 391 GNRLTSLPV-LPSELKELMVSGNRLTSLPM-LPSG---------LLSLSVYRNQLTRLPESLI-HLSSETTVNLEGNPLs 458

                        330
                 ....*....|....
gi 5031707   352 -RTFEA-RRLGSLP 363
Cdd:PRK15387 459 eRTLQAlREITSAP 472
LRR_8 pfam13855
Leucine rich repeat;
365-422 7.40e-07

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 46.75  E-value: 7.40e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 5031707    365 LMLLDLSHNALETLELGA-RALGSLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNRV 422
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAfKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 100-386 4.04e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 49.79  E-value: 4.04e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  100 EHLSLAHNRLAMATALSAGGLGPLPRVTSLDLSGNSLYSGLLERL---LGEAPSLHTLSLAENSLTRLTRHTFRDM---- 172
Cdd:COG5238 156 VHLLGLAARLGLLAAISMAKALQNNSVETVYLGCNQIGDEGIEELaeaLTQNTTVTTLWLKRNPIGDEGAEILAEAlkgn 235

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  173 PALEQLDLHSNvlmDIEDGAFEGLprLTHLNLSRnsltcisdfslqQLRVLDLSCNSIE---AFQTASQPQAEFQLTWLD 249
Cdd:COG5238 236 KSLTTLDLSNN---QIGDEGVIAL--AEALKNNT------------TVETLYLSGNQIGaegAIALAKALQGNTTLTSLD 298

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  250 LRENKLlHFPDLAAL-------PRLIYLNLSNNLIRlptgppqdskgihapSEGWSALPlsapsgnASGRPLSQLLNLDL 322
Cdd:COG5238 299 LSVNRI-GDEGAIALaeglqgnKTLHTLNLAYNGIG---------------AQGAIALA-------KALQENTTLHSLDL 355

                       250       260       270       280       290       300       310
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  323 SYNEI------ELIpdSFLEHLTSLCFLNLSRNCLRTFEARRLGSLpclmlldLSHNALETLELGARALG 386
Cdd:COG5238 356 SDNQIgdegaiALA--KYLEGNTTLRELNLGKNNIGKQGAEALIDA-------LQTNRLHTLILDGNLIG 416
LRRNT smart00013
Leucine rich repeat N-terminal domain;
21-52 1.28e-05

Leucine rich repeat N-terminal domain;


Pssm-ID: 214470 [Multi-domain]  Cd Length: 33  Bit Score: 42.30  E-value: 1.28e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 5031707      21 QDKVPCKMVDKKVSCQVLGLLQVPSVLPPDTE 52
Cdd:smart00013   1 ACPAPCNCSGTAVDCSGRGLTEVPLDLPPDTT 32
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 54-179 2.04e-05

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 46.32  E-value: 2.04e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   54 LDLSGNQLRSIlaSPLGFYTALRHLDLSTNEISFLQpgAFQALTHLEHLSLAHNRLA----------MATALSA------ 117
Cdd:cd21340  51 LYLQNNQIEKI--ENLENLVNLKKLYLGGNRISVVE--GLENLTNLEELHIENQRLPpgekltfdprSLAALSNslrvln 126

                        90       100       110       120       130       140       150
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 5031707  118 ---------GGLGPLPRVTSLDLSGNSLYSGL-LERLLGEAPSLHTLSLAENSLTRLTRhtFRD-----MPALEQLD 179
Cdd:cd21340 127 isgnnidslEPLAPLRNLEQLDASNNQISDLEeLLDLLSSWPSLRELDLTGNPVCKKPK--YRDkiilaSKSLEVLD 201
PLN03150 PLN03150
hypothetical protein; Provisional
 330-423 2.21e-05

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 47.50  E-value: 2.21e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   330 IPD--SFLEHLTSLcflNLSRNCLRTFEARRLGSLPCLMLLDLSHNALEtlelgaralGSLrtlllqgnalrdlpPYTFA 407
Cdd:PLN03150 434 IPNdiSKLRHLQSI---NLSGNSIRGNIPPSLGSITSLEVLDLSYNSFN---------GSI--------------PESLG 487

                         90
                 ....*....|....*.
gi 5031707   408 NLASLQRLNLQGNRVS 423
Cdd:PLN03150 488 QLTSLRILNLNGNSLS 503
LRR_8 pfam13855
Leucine rich repeat;
387-455 2.27e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 42.51  E-value: 2.27e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 5031707    387 SLRTLLLQGNALRDLPPYTFANLASLQRLNLQGNR---VSPcggpdepgpsgcVAFSGITSLRSLSLVDNEI 455
Cdd:pfam13855   2 NLRSLDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLlttLSP------------GAFSGLPSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 344-577 2.90e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 46.58  E-value: 2.90e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  344 LNLSRNCLRTFEARR-LGSLPCLMLLDLSHNALEtlELGARALG-------SLRTLLLQGNALRDLPPYT------FANL 409
Cdd:cd00116   3 LSLKGELLKTERATElLPKLLCLQVLRLEGNTLG--EEAAKALAsalrpqpSLKELCLSLNETGRIPRGLqsllqgLTKG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  410 ASLQRLNLQGNRVSPcggpdePGPSGCVAFSGITSLRSLSLVDNEIELlRAGAFLHT-------PLTELDLS----SNPG 478
Cdd:cd00116  81 CGLQELDLSDNALGP------DGCGVLESLLRSSSLQELKLNNNGLGD-RGLRLLAKglkdlppALEKLVLGrnrlEGAS 153

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  479 LEVATGALGGLeASLEVL-----ALQGNGLMVLQVDLPCFICLKRLNLAENRLSHL------PAWTQAVSLEVLDLRNNS 547
Cdd:cd00116 154 CEALAKALRAN-RDLKELnlannGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEgasalaETLASLKSLEVLNLGDNN 232

                       250       260       270
                ....*....|....*....|....*....|....
gi 5031707  548 FSLLP----GSAMGGLETSLRRLYLQGNPLSCCG 577
Cdd:cd00116 233 LTDAGaaalASALLSPNISLLTLSLSCNDITDDG 266
LRR_8 pfam13855
Leucine rich repeat;
516-573 3.86e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 41.74  E-value: 3.86e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707    516 LKRLNLAENRLSHLP--AWTQAVSLEVLDLRNNSFSLLPGSAMGGLeTSLRRLYLQGNPL 573
Cdd:pfam13855   3 LRSLDLSNNRLTSLDdgAFKGLSNLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 312-549 6.60e-05

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 45.42  E-value: 6.60e-05
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  312 RPLSQLLNLDLSYNEIELIPD------SFLEHLTSLCFLNLSRNCLRTFEARRLGSL---PCLMLLDLSHNALET--LEL 380
Cdd:cd00116  48 RPQPSLKELCLSLNETGRIPRglqsllQGLTKGCGLQELDLSDNALGPDGCGVLESLlrsSSLQELKLNNNGLGDrgLRL 127

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  381 GARALGS----LRTLLLQGNALRDLPPYTFANLA----SLQRLNLQGNRVSPCGGPdepgpSGCVAFSGITSLRSLSLVD 452
Cdd:cd00116 128 LAKGLKDlppaLEKLVLGRNRLEGASCEALAKALranrDLKELNLANNGIGDAGIR-----ALAEGLKANCNLEVLDLNN 202

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707  453 NEIELLRAGAFLHTP-----LTELDLSSNPGLEVATGALggLEASLEVLalqgnglmvlqvdlpcfICLKRLNLAENRLS 527
Cdd:cd00116 203 NGLTDEGASALAETLaslksLEVLNLGDNNLTDAGAAAL--ASALLSPN-----------------ISLLTLSLSCNDIT 263

                       250       260
                ....*....|....*....|....*...
gi 5031707  528 HLPAWTQA------VSLEVLDLRNNSFS 549
Cdd:cd00116 264 DDGAKDLAevlaekESLLELDLRGNKFG 291
LRRNT pfam01462
Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence ...
 21-48 8.00e-05

Leucine rich repeat N-terminal domain; Leucine Rich Repeats pfam00560 are short sequence motifs present in a number of proteins with diverse functions and cellular locations. Leucine Rich Repeats are often flanked by cysteine rich domains. This domain is often found at the N-terminus of tandem leucine rich repeats.


Pssm-ID: 396168 [Multi-domain]  Cd Length: 28  Bit Score: 39.92  E-value: 8.00e-05
                          10        20
                  ....*....|....*....|....*...
gi 5031707     21 QDKVPCKMVDKKVSCQVLGLLQVPSVLP 48
Cdd:pfam01462   1 ACPVPCHCSATVVNCSDRGLTAVPRDLP 28
PLN03150 PLN03150
hypothetical protein; Provisional
 52-135 2.11e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.42  E-value: 2.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707    52 ETLDLSGNQLRSILASPLGFYTALRHLDLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLgPLPRvTSLDL 131
Cdd:PLN03150 445 QSINLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRILNLNGNSLSGRVPAALGGR-LLHR-ASFNF 522


                 ....
gi 5031707   132 SGNS 135
Cdd:PLN03150 523 TDNA 526
PLN03150 PLN03150
hypothetical protein; Provisional
 496-654 3.08e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 44.04  E-value: 3.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   496 LALQGNGLM-VLQVDLPCFICLKRLNLAENRLSHL--PAWTQAVSLEVLDLRNNSFS-LLPGSAmgGLETSLRRLYLQGN 571
Cdd:PLN03150 423 LGLDNQGLRgFIPNDISKLRHLQSINLSGNSIRGNipPSLGSITSLEVLDLSYNSFNgSIPESL--GQLTSLRILNLNGN 500

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   572 PLSCCGNGWLAAQ-LHQGRVDVDATQDLiCrfssqeevSLSHVRPedCekGGLKNINLIIILTF-ILVSAILLTTLAACC 649
Cdd:PLN03150 501 SLSGRVPAALGGRlLHRASFNFTDNAGL-C--------GIPGLRA--C--GPHLSVGAKIGIAFgVSVAFLFLVICAMCW 567


                 ....*
gi 5031707   650 CVRRQ 654
Cdd:PLN03150 568 WKRRQ 572
PLN03150 PLN03150
hypothetical protein; Provisional
 54-152 9.91e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.11  E-value: 9.91e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707    54 LDLSGNQLRSILASPLgfyTALRHL---DLSTNEISFLQPGAFQALTHLEHLSLAHNRLAMATALSAGGLGPLPRvtsLD 130
Cdd:PLN03150 423 LGLDNQGLRGFIPNDI---SKLRHLqsiNLSGNSIRGNIPPSLGSITSLEVLDLSYNSFNGSIPESLGQLTSLRI---LN 496

                         90       100
                 ....*....|....*....|..
gi 5031707   131 LSGNSLySGLLERLLGEAPsLH 152
Cdd:PLN03150 497 LNGNSL-SGRVPAALGGRL-LH 516
LRR_8 pfam13855
Leucine rich repeat;
443-503 2.50e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.73  E-value: 2.50e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 5031707    443 TSLRSLSLVDNEIELLRAGAFLHTP-LTELDLSSNPGLEVATGALGGLeASLEVLALQGNGL 503
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGLSnLKVLDLSNNLLTTLSPGAFSGL-PSLRYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
197-255 2.73e-03

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 36.35  E-value: 2.73e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 5031707    197 PRLTHLNLSRNSLTCISD---FSLQQLRVLDLSCNSIEAFqtasqPQAEFQ----LTWLDLRENKL 255
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDgafKGLSNLKVLDLSNNLLTTL-----SPGAFSglpsLRYLDLSGNRL 61
PLN03150 PLN03150
hypothetical protein; Provisional
 260-363 4.85e-03

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 40.18  E-value: 4.85e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031707   260 DLAALPRLIYLNLSNNLIRlptgppqdskgihapsegwSALPLSApsGNASGrplsqLLNLDLSYNEIE-LIPDSfLEHL 338
Cdd:PLN03150 437 DISKLRHLQSINLSGNSIR-------------------GNIPPSL--GSITS-----LEVLDLSYNSFNgSIPES-LGQL 489

                         90       100
                 ....*....|....*....|....*
gi 5031707   339 TSLCFLNLSRNCLRTFEARRLGSLP 363
Cdd:PLN03150 490 TSLRILNLNGNSLSGRVPAALGGRL 514
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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