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Conserved domains on  [gi|5031999|ref|NP_005659|]
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CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase isoform a precursor [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 10466376)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.-.-
Gene Ontology:  GO:0006486|GO:0008373
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 76-353 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


:

Pssm-ID: 467716  Cd Length: 278  Bit Score: 614.66  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999   76 SLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSE 155
Cdd:cd23988   1 SLVLEIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  156 CGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEK 235
Cdd:cd23988  81 CGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  236 HVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYH 315
Cdd:cd23988 161 HVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYH 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 5031999  316 YYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTT 353
Cdd:cd23988 241 YYDDLKYRYFSNAGPHRMPLEFKTLNVLHNRGALKLTT 278
 
Name Accession Description Interval E-value
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 76-353 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 614.66  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999   76 SLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSE 155
Cdd:cd23988   1 SLVLEIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  156 CGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEK 235
Cdd:cd23988  81 CGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  236 HVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYH 315
Cdd:cd23988 161 HVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYH 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 5031999  316 YYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTT 353
Cdd:cd23988 241 YYDDLKYRYFSNAGPHRMPLEFKTLNVLHNRGALKLTT 278
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 96-348 2.22e-104

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 307.23  E-value: 2.22e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999     96 SVVKSSFKPGDVIHYVlDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVV 175
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999    176 EFAADVGTKSDFITMNP-SVVQRAFGGFRNESDREKFVHRLSML--NDSVLWIPAFMVKGGEKHVEWVNALILKNKLKV- 251
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999    252 --RTAYPSLRLIHAVRGYWL-TNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFpkdLNGKAVKYHYYDDLKYRYFSNA 328
Cdd:pfam00777 160 pdKVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMKKGGFY 236

                         250       260
                  ....*....|....*....|
gi 5031999    329 SPHRMPLEFKTLNVLHNRGA 348
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
 
Name Accession Description Interval E-value
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 76-353 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 614.66  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999   76 SLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSE 155
Cdd:cd23988   1 SLVLEIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISQNLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  156 CGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEK 235
Cdd:cd23988  81 CGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEK 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  236 HVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYH 315
Cdd:cd23988 161 HVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVNIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDANGNPVKYH 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 5031999  316 YYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTT 353
Cdd:cd23988 241 YYDDLKYRYFSNAGPHRMPLEFKTLNVLHNRGALKLTT 278
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 76-353 0e+00

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 518.51  E-value: 0e+00
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999   76 SLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSE 155
Cdd:cd23969   1 TEVLRMRKWILKFFDPEKDISVLKSQVKPGDRMHYEIDRHKTVNITQDLYQLLPEVSPLKGKHFRTCAVVGNSGILLNSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  156 CGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEK 235
Cdd:cd23969  81 CGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNLTTMNPSVIPHAYGDLVNATDKEKFVERLRQLGDSILWIPAFVSKGGEE 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  236 HVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYH 315
Cdd:cd23969 161 HVQWTNEIILKHKLNVKTAYPPLRLNHAIRGYWLTTKFRIKRPSTGLLMYTLATRFCDEIHLYGFYPFSEDGNGRAVKYH 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 5031999  316 YYDDLKYRYfsNASPHRMPLEFKTLNVLHNRGALKLTT 353
Cdd:cd23969 241 YYDNRKYLT--TARPHKMPEEFRALRSLHQRGALRLHT 276
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 76-353 8.74e-177

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 491.76  E-value: 8.74e-177
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999   76 SLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSE 155
Cdd:cd23987   1 TLSLKIRKQILKFLDAERDISVLKGTLKPGDVIHYVFDRDSTMNISQNLYELLPRTSPLKNKHFKTCAIVGNSGILLNSG 80

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  156 CGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEK 235
Cdd:cd23987  81 CGREIDSHDFVIRCNLAPVEEYAKDVGTKTDLVTMNPSVVQRAFEDLVNETWKEKFLQRLQSLNGSILWIPAFMAKGGEE 160

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  236 HVEWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYH 315
Cdd:cd23987 161 RVEWVNDLILKHHINVRTAYPSLRLLHAVRGYWLTNKVHIKRPTTGLLMYTLATRFCNRIHLYGFWPFPRDQNQNPVKYH 240

                       250       260       270
                ....*....|....*....|....*....|....*...
gi 5031999  316 YYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKLTT 353
Cdd:cd23987 241 YYDSLKYGYTSQASPHTMPLEFKALKNLHQQGALKLTV 278
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 78-353 7.25e-117

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 339.62  E-value: 7.25e-117
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999   78 VLEIRKNILRFLDAERDVsVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECG 157
Cdd:cd23963   3 LDKFRKELERLLNTRKLF-LTQKNTPLGDVLYYSYFKKKTFKITKSLYELLPKTSPFSHKRYKTCAVVGNSGILLGSGCG 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  158 KEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHV 237
Cdd:cd23963  82 KEIDSHDFVIRCNLPPIKGFEKDVGRKTNLTTLNPSILKRRYNSLKKNRDRDKFLNRLKEYNGSILWYPKFSFKSSTNLL 161

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  238 EWVNALILKNKLKVRTAYPSLRLIHAVRGYWLTNKVPiKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYY 317
Cdd:cd23963 162 LKAARALKKNGLNLTVVYSNPEHFLAVQKFWKRRGLE-KRPSTGLYLVSLALTFCDEIHLYGFWPFPTDPNGRPVPYHYY 240

                       250       260       270
                ....*....|....*....|....*....|....*.
gi 5031999  318 DDLKYRYFSNasPHRMPLEFKTLNVLHNRGALKLTT 353
Cdd:cd23963 241 DDLSPSTKNK--VHNMPEEFKLLRELHKKGVLKLHT 274
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 96-348 2.22e-104

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 307.23  E-value: 2.22e-104
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999     96 SVVKSSFKPGDVIHYVlDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVV 175
Cdd:pfam00777   1 FLTKENFPLGEWIRYS-EWWLPFTVTEELLELLPKVSPFDNKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTK 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999    176 EFAADVGTKSDFITMNP-SVVQRAFGGFRNESDREKFVHRLSML--NDSVLWIPAFMVKGGEKHVEWVNALILKNKLKV- 251
Cdd:pfam00777  80 GYEKDVGSKTTLRTMNPeSAIDSKYGNLGFSHPRDPFVEFVLVPfkGRDLLWLPAFLTKGNVSRSLRVLYTLKEVKIPVd 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999    252 --RTAYPSLRLIHAVRGYWL-TNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFpkdLNGKAVKYHYYDDLKYRYFSNA 328
Cdd:pfam00777 160 pdKVLFLHPDFLRYVANFWLrSHGLKGRRPSTGLLMLSLALHLCDEVSLYGFGPF---LDSRGNSHHYYDNVLMKKGGFY 236

                         250       260
                  ....*....|....*....|
gi 5031999    329 SPHRMPLEFKTLNVLHNRGA 348
Cdd:pfam00777 237 GVHDMPFEFKLLQKLHKEGV 256
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 74-353 4.51e-95

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 284.67  E-value: 4.51e-95
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999   74 NSSLVLEIRKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLN-ISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILL 152
Cdd:cd23970   2 NKTALLHQRKEIRQYFDVIKNISLTKKDVRIGQLMHFDYSSHKYVFsISPNLRSLLPEVSPFQNKHYNTCAVVGNSGILT 81

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  153 DSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLNDSVLWIPAFMvkg 232
Cdd:cd23970  82 NSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFF--- 158

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  233 geKHVEWVNALIL-------KNKLKVRTAYPSLRLIHaVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPK 305
Cdd:cd23970 159 --FHTSATVTRTLvdffvehRGQLKVQLAWPGNIMQH-VNRYWKTKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGF 235

                       250       260       270       280       290
                ....*....|....*....|....*....|....*....|....*....|....
gi 5031999  306 DLNGKAVKYHYYD------DLKYRYFsnaspHRMPLEFKTLNVLHNRGALKLTT 353
Cdd:cd23970 236 DPTGTPLPYHYYDkkgtkfTTKWQES-----HQLPAEFVLLYKMHGAGVLKLTL 284
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 105-351 4.90e-72

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 225.21  E-value: 4.90e-72
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  105 GDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPvVEFAADVGTK 184
Cdd:cd23971  30 GSKIHYEGERKKTITVNEKLFSMLPKESPFSNKPLKTCAVVGNGGILKNSSCGREIDSADFVIRCNLPP-LNDSKDVGSK 108

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  185 SDFITMNPSVVQRAFGGFRNEsdREKFVHRLSMLNDSVLWIPAF-MVKGGEKHVEWVNALI-LKNKLKVRTAYPS-LRLI 261
Cdd:cd23971 109 TNLVTANPSILREKFHNLKKR--RRPFVERMKVYGNALLLLPAFsYTSNTEPSLRALYTLEdFGSPQKVLFFNPEyLRNL 186

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  262 HAvrgYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKyryfSNASPHRMPLEFKTLN 341
Cdd:cd23971 187 SR---YWKSKGLKARRLSTGLMLVSAALELCENVHLYGFWPFSTDLDGNPISHHYYDNVL----PKKGVHAMPEEFLRYL 259

                       250
                ....*....|
gi 5031999  342 VLHNRGALKL 351
Cdd:cd23971 260 KLHSQGVLRL 269
GT29_ST8SIA1 cd23989
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2, ...
 82-351 3.50e-59

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1 (also known as ganglioside GD3 synthase) adds sialic acids to GM3 ganglioside. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze analpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467717  Cd Length: 272  Bit Score: 192.35  E-value: 3.50e-59
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999   82 RKNILRFLDAERDVSVVKSSFKPGDVIHYVLDRRRTLNISHDLHSLLPEVSPMKnRRFKTCAVVGNSGILLDSECGKEID 161
Cdd:cd23989   7 RKLLEDCCDPKRLFAVTKHNSPLGKNLWFDGEFLHSHTVDNETYSLFPQDTPLQ-LPLKKCSVVGNGGILKNSGCGQQID 85

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  162 SHNFVIRCNLAPVV-EFAADVGTKSDFITMNPSVVQRAFGGFrnESDREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWV 240
Cdd:cd23989  86 RADFVMRCNLPPLSrEYTDDVGTKTQLVTANPSIIDKRFQNL--LWSRKSFVESMKVYGRSYIYMPAFSMKTGTDPSLRV 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  241 nALILKN---KLKVRTAYPSLrlIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYY 317
Cdd:cd23989 164 -YYTLADvgaNQTVLFANPNF--LRNVGKFWKSKGVHAKRLSTGLFLVSAALGLCEEVTIYGFWPFSVDLDERTISHHYY 240

                       250       260       270
                ....*....|....*....|....*....|....
gi 5031999  318 DDLkyryFSNASPHRMPLEFKTLNVLHNRGALKL 351
Cdd:cd23989 241 DNV----LPDSGFHAMPEEFLQLWHLHKSGVLRM 270
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 105-351 6.81e-56

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 183.80  E-value: 6.81e-56
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  105 GDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVV-EFAADVGT 183
Cdd:cd23991  30 GTNLTYEVEPKKKILITENIFRMFPKSQPFRGYPYKQCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGgNISKDVGS 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  184 KSDFITMNPSVVQRAFGGFRNEsdREKFVHRLSMLNDSVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRLIHA 263
Cdd:cd23991 110 KTNLVTANPSIISIKYAKLNER--RKPFLETVSVYGDAFLLLPAFSYRSNTALSFKVYYTLEDFKAKQKVIFFHPIYLKH 187

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  264 VRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLkyryFSNASPHRMPLEFKTLNVL 343
Cdd:cd23991 188 LAQFWRSKGVQVYRLSTGLMITSAALELCEEVKLYGFWPFSKNTEGKPISHHYYDNQ----LPKPGFHSMPKEFYQLLQL 263


                ....*...
gi 5031999  344 HNRGALKL 351
Cdd:cd23991 264 HSKGILKL 271
GT29_ST8SIA5 cd23990
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2, ...
 105-353 7.45e-50

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 5 (also known as alpha-2,8-sialyltransferase 8E) is involved in the biosynthesis of gangliosides, such as GD1c, GT1a, GQ1b, and GT3. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467718  Cd Length: 273  Bit Score: 168.09  E-value: 7.45e-50
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  105 GDVIHYVLDRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVE-FAADVGT 183
Cdd:cd23990  30 GTKLKYEVDTSGIYHINSEIFKMFPKDMPYSRSQFKKCAVVGNGGILKNSKCGREIDSADFVFRCNLPPISEkYVRDVGV 109

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  184 KSDFITMNPSVVQRAFGGFrnESDREKFVHRLSMLNDSVLWIPAFMvkggekhvewvNALILKNKLKVRTA--------- 254
Cdd:cd23990 110 KTDVVTINPSIITERFHKL--EKWRRPFYEVLQVYENASVVLPAFY-----------NTRNTDVSIRVKYVlddfesqqa 176

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  255 --YPSLRLIHAVRGYWLTNKVPIKRPSTGLLMYTLATRFCDEIHLYGFWPFPKDLNGKAVKYHYYDDLKYRyfsnASPHR 332
Cdd:cd23990 177 vyYFHPQYLLNVSRFWLRQGVRAKRISSGLMLVTAALELCEEVHLYGFWAFPMNPSGIFITHHYYDNVKPR----PGFHA 252

                       250       260
                ....*....|....*....|.
gi 5031999  333 MPLEFKTLNVLHNRGALKLTT 353
Cdd:cd23990 253 MPSEIFNFLHMHSRGILRVHT 273
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 142-343 1.50e-40

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 141.35  E-value: 1.50e-40
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  142 CAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVqrafgGFRNESDReKFVHRLSMLNDS 221
Cdd:cd19952   1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWA-----GFYLRGPR-CGCHPLPLEEEV 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  222 VLWIPAFMVKgGEKHVEWVNALILKNKLKVRTAYPslRLIHAVRGYW--LTNKVPI--KRPSTGLLMYTLATRFCDEIHL 297
Cdd:cd19952  75 VLILSRAAAA-DFKRLKRRKKRHDNAVLLLTDPAP--DLLSYVRKRLekLGLKSFFggNAPSSGLLAVLLALQLCDSVDL 151

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*.
gi 5031999  298 YGFWPFPKDlnGKAVKYHYYDdlKYRYFSNASPHRMPLEFKTLNVL 343
Cdd:cd19952 152 YGFGVDSGH--APKVPYHYYD--LVEAEEGTAVHSFDLEAELLRAL 193
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 128-342 6.39e-26

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 104.66  E-value: 6.39e-26
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  128 LPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVqrafggfrnESD 207
Cdd:cd23968  34 FPESSLENTKRYNTCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSKTTLRLINSQIL---------SKP 104

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  208 REKFVHRLSMLNDSVL-WIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPSLRL-IHAVRGYW-------LTNKVPIKR- 277
Cdd:cd23968 105 EFNFLTDPLYRNVTLLvWDPSSYNVNLEKWYKKPDFDFFPNYIKYRRRHPEEPFyLIDPRFLWrlwdilqEYTPEKIKPn 184

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 5031999  278 -PSTGLLMYTLATRFCDEIHLYGFWPfPKDLNGKAvkyHYYDDLKYRYFSNASPHrmPLEF-----KTLNV 342
Cdd:cd23968 185 pPSSGFIGIVLMLHLCDWVDVYEYVP-SVRQTDRC---HYYDVEKDLACTLGAWH--PLAAekllvRHLNV 249
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 141-351 6.65e-25

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 102.34  E-value: 6.65e-25
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  141 TCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESDREKFVHRLSMLND 220
Cdd:cd23964  84 RCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLLKHVPQDKDTKYLFIPFKIRD 163

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  221 SVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAypSLRLIHA-----VRGYWLtNKVPIKRPSTGLLMYTLATRFCDEI 295
Cdd:cd23964 164 YDYLDAVLSGKPVPDGCDKGKRPPPLFGPKLNAT--NVRLLHPdfiryLFNRWL-NSSTSYRPTTGALMLLTALHTCDQV 240

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*...
gi 5031999  296 HLYGFwpfpkdlnGKAVKY--HYYDDLKYRYFSNASPHRMPLEFKTLNVLHNRGALKL 351
Cdd:cd23964 241 SVYGF--------GYDPRFslHYYDKTFVKFTVFYANHDFTNERKLWRKLHEEGIINL 290
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 130-351 1.55e-21

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 92.73  E-value: 1.55e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  130 EVSPMKNR-------RFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPsvvqrafggf 202
Cdd:cd23966  61 QVVPGENPyrtrdpnRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFMYP---------- 130

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  203 rnesdrEKFVHrlsmLNDSV--LWIPaFMVKGgekhVEWVNAlILKNKLKVRTAYPSLRLIHAVRgywltNKVPI----- 275
Cdd:cd23966 131 ------ESAVD----LDPGVhlVLVP-FKVLD----LQWLIS-ALTTGEITRTYTPVKRFIKADK-----DKVLVinpaf 189

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  276 -------------KRPSTGLLMYTLATRFCDEIHLYGF-------WpfpkdlngkavkYHYYDDLKYRY-FSNASPHRMP 334
Cdd:cd23966 190 ikyvhdnwtehhgRYPSTGFLALIFALHICDEVSVFGFgadskgnW------------HHYWEKNRSAGaFRKTGVHDAD 257

                       250
                ....*....|....*..
gi 5031999  335 LEFKTLNVLHNRGALKL 351
Cdd:cd23966 258 FESDIIKKLAKEGKIRV 274
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 140-321 8.36e-21

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 88.89  E-value: 8.36e-21
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  140 KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFitmnpsvvqRAF---GGFRNESDREK---FVH 213
Cdd:cd23967   3 RRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTF---------RMFypeSAFRDPEEYDSdwlLVL 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  214 RLSMLNDsVLWIPAF-----MVKGGEKHVEWVNALIlKNKLKVRTAYPSLRLIHAVR--GYWLTNKVPIKRPSTGLLMYT 286
Cdd:cd23967  74 VPFKSMD-LLWLQAVikgkkPNGKGGFWKKIATSVP-KPPKKIRILNPYILQEAAFDliGLPMNGKQGKNVPTTGIIAIV 151

                       170       180       190
                ....*....|....*....|....*....|....*
gi 5031999  287 LATRFCDEIHLYGFWPFPKDLNgkaVKYHYYDDLK 321
Cdd:cd23967 152 MALHYCDEVDIAGFGYDPSDPN---APLHYYDSLT 183
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 123-319 4.14e-18

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 83.39  E-value: 4.14e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  123 DLHSLLP-EVSPMKNRRF---KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPsvvqra 198
Cdd:cd23980  61 ELFQVVPgNVDPLLEKRLvscRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSKTTHHFVYP------ 134

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  199 fggfrnESDREkFVHRLSML-----NDSVLWIPAFMVKGGEKHVEW-VNALILKNKLKVRTAYPSlrLIHAVRGYWLTNK 272
Cdd:cd23980 135 ------ESFRE-LAQNVSMIlvpfkTLDLEWVISATTTGTISHTYVpVPRKIKVKKEKILIYHPA--FIKYVFDRWLQGH 205

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....*..
gi 5031999  273 VpiKRPSTGLLMYTLATRFCDEIHLYGFwpfpkDLNGKAVKYHYYDD 319
Cdd:cd23980 206 G--RYPSTGILSVIFSLHVCDEVDLYGF-----GADSKGNWHHYWEN 245
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 116-351 9.38e-18

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 82.56  E-value: 9.38e-18
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  116 RTLNISHDLHSLLPEVSPMKNRRfktCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFI-----TM 190
Cdd:cd23972  62 SLLNDSANAKLFFPRDTPGKCIR---CAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYgftvnTM 138

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  191 NPSVVQ-RAFGGFRNESDRE-KFVHRLSMLNDSVLW--------IPAFMVKGGEKHVEW-VNALILKNKLkvrtAYPSlr 259
Cdd:cd23972 139 KNSLISyWNLGFTRTPQGQDlQYIFIPSDIRDYVMLrsailgvpVPEGLDKGDRPHKYFgPEASAKKFKL----LHPD-- 212

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  260 LIHAVRGYWLTNKV------PIKRPSTGLLMYTLATRFCDEIHLYGFWpfpkDLNGKAVKYHYYDDLK--YRYFSNaspH 331
Cdd:cd23972 213 FISYLTDRFLKSKLlnthygHLYMPSTGALMLLTALHTCDQVSAYGFI----TSNYWKFSDHYYERKKkpLVFYAN---H 285

                       250       260
                ....*....|....*....|
gi 5031999  332 RMPLEFKTLNVLHNRGALKL 351
Cdd:cd23972 286 DMLLEAALWRRLHKAGILQL 305
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 140-323 1.40e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 80.75  E-value: 1.40e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  140 KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSD-----FITMnPSVVQRAFGGFRNESdREKFVhr 214
Cdd:cd23965   2 DTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTirvvsHSSL-PRLLRNAILLLAGTR-APTVV-- 77

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  215 lsmlndsVLWIPAF-MVKGGEKHVewvnaLILKNKLKVrtaYPSLRLIHAVR---------------------GYWLtnk 272
Cdd:cd23965  78 -------VFWGPETkMNKDGAGKY-----NLLRSLSKK---YPDVEFYSLTPekmdyadelfeketgksriksGTWL--- 139

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|...
gi 5031999  273 vpikrpSTGLLMYTLATRFCDEIHLYGFWP--FPKDLNGKAVKYHYYDDLKYR 323
Cdd:cd23965 140 ------STGWFTMLLALDVCDEIKVYGMVPenYCREHPNSKVPYHYYEPGGLK 186
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 124-351 2.67e-17

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 81.34  E-value: 2.67e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  124 LHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFI-----TMNPSVVQRA 198
Cdd:cd23973  68 KEQQLLALSPPGGDGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYvhtahSITSSLMILQ 147

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  199 FGGFRN-ESDRE-KFVHRLSMLNDsvlwipafmvkggekhVEWVNALiLKNKLKVRTAYPSLR---------------LI 261
Cdd:cd23973 148 KRGFKNiPQDKDiKYILFPEGPRD----------------YQWLEAL-LKNKTIPSGAYYGRRprsyfsgdftedkylVL 210

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  262 HA-----VRGYWLTNKV------PIKRPSTGLLMYTLATRFCDEIHLYGFwpfpkdLNGKAVKY--HYYDDLKYR--YFS 326
Cdd:cd23973 211 HPdflryVKNRFLRSKTlkgkywAIYRPTTGAFLLLTALHLCDTVSAYGF------ITEDYRKYpdHYYDKKKTKlvFYI 284

                       250       260
                ....*....|....*....|....*
gi 5031999  327 NaspHRMPLEFKTLNVLHNRGALKL 351
Cdd:cd23973 285 N---HDFRLEKKLWKRLHDEKIIKL 306
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 81-351 4.12e-17

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 80.30  E-value: 4.12e-17
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999   81 IRKNILRFLDAERDVSVVKSSFKPGDvIHYVLDRrrtlnishdLHSLLPEVSPMKNR---RFKTCAVVGNSGILLDSECG 157
Cdd:cd23979  29 TKENMELPPDVQYWWMMLQPQFKPHN-TKEVLSK---------LFQIIPGENPYRSWdpsRCRRCAVVGNSGNLRGSGYG 98

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  158 KEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVqrafggfRNESDREKFVHRLSMLNDsVLWIPAFMVKGGEKHV 237
Cdd:cd23979  99 KDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESA-------KNLPANVSFVLVPFKTLD-LLWITSALSTGQIRFT 170

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  238 -EWVNALILKNKLKVRTAYPS-LRLIHavrGYWLTNKVpiKRPSTGLLMYTLATRFCDEIHLYGFwpfpkDLNGKAVKYH 315
Cdd:cd23979 171 yAPVKQFLRVDKDKVQIYNPAfFKYIH---DRWTEHHG--RYPSTGMLVLFFALHVCDEVNVYGF-----GADSRGNWHH 240

                       250       260       270
                ....*....|....*....|....*....|....*..
gi 5031999  316 YYDDLKYR-YFSNASPHRMPLEFKTLNVLHNRGALKL 351
Cdd:cd23979 241 YWENNRYAgEFRKTGVHDADFEAHIIDMLAKAGKIKV 277
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 137-302 1.57e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 78.60  E-value: 1.57e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  137 RRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQrafggfrneSDREKFvHRLS 216
Cdd:cd23985  43 GPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLINSQLVT---------TEKHKF-LKDS 112

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  217 MLNDSVL--WIPAfmVKGGEKHvEWVNalilKNKLKVRTAYPSLRLIHAVRGYWLTN-KVP--------------IKR-- 277
Cdd:cd23985 113 LYNEGILivWDPA--PYHSDIP-EWYK----NPDYNFFENYKTYRRLNPNQPFYILHpQMQwelwdiiqenspeeIQPnp 185

                       170       180
                ....*....|....*....|....*
gi 5031999  278 PSTGLLMYTLATRFCDEIHLYGFWP 302
Cdd:cd23985 186 PSSGMLGIILMMTLCDQVDVYEFLP 210
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 140-340 8.95e-16

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 75.09  E-value: 8.95e-16
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  140 KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSdfiTMnpsvvqRAF--------GGFRNESDrEKF 211
Cdd:cd23982   3 RRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKT---TI------RLFypesaqfdPGIENDPD-TLL 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  212 VHrLSMLNDSVLWIPAFMV------KGGEKHV--EWvnaliLKNKLKVRTAYPSLRLIHAVRGYWLTNKVPIK-RPSTGL 282
Cdd:cd23982  73 VL-VPFKPLDFYWLYEILSnekrvrKGFWKQPprIW-----DANPKQIRILNPYYTYVAATKLLQVPGQRKKKqKPTTGL 146

                       170       180       190       200       210
                ....*....|....*....|....*....|....*....|....*....|....*....
gi 5031999  283 LMYTLATRFCDEIHLYGF-WPfpkDLNGKAVKYHYYDDLKYRYFSNaSPHRMPLEFKTL 340
Cdd:cd23982 147 LAITLALHLCDEVHIAGFgYP---DNGNSNQPIHYYNQITLKSMAN-SGHNLNAEAQAI 201
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 113-351 1.47e-15

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 76.33  E-value: 1.47e-15
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  113 DRRRTLNISHDLHSLLPEVSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNP 192
Cdd:cd23974  58 DALNLLNSSANGQMFDWWDRPNGRSPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFST 137

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  193 SVVQ---RAFGG---------------FRNESDREKFVHRLSMLNDSVLWIPafmvKGGEKHVEWVNALILKNKLKVrtA 254
Cdd:cd23974 138 NTLMnslRAYAGvgfngppqsketryiFLPDHDRDYLLVKAALTHTPIDRGR----DKSKRPSKYFGKDVTAEKFKI--Y 211

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  255 YPSlrLIHAVRGYWL------TNKVPIKRPSTGLLMYTLATRFCDEIHLYGFwpFPKDLNgkavKY--HYYDDL--KYRY 324
Cdd:cd23974 212 HPD--FIRYLRNRFLwspilnTKQRDIYRPSTGAVMLLAALHTCDQVSAYGF--MTPDYG----KYsdHYYDKTyhKVVF 283

                       250       260
                ....*....|....*....|....*..
gi 5031999  325 FSNaspHRMPLEFKTLNVLHNRGALKL 351
Cdd:cd23974 284 YAN---HDLRLEMQLWQKLHKAGLIKL 307
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 140-319 1.07e-14

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 72.09  E-value: 1.07e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  140 KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVqrafggFRNESDREKfvhrlsmln 219
Cdd:cd23984   3 KKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESI------FSDPSHYDP--------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  220 DSVLWIPAFMvkggEKHVEWVNALILKNKLKVRTAY--PSLRLI---HAVR----------GYWLTN-------KVPIKR 277
Cdd:cd23984  68 NTTVVLIPFK----PHDLRWLLDLLMGKKVSAKGFWkkPALNLIykpNQIRilnpfilriaAYELLHfpkrfpkEKKPKH 143

                       170       180       190       200
                ....*....|....*....|....*....|....*....|..
gi 5031999  278 PSTGLLMYTLATRFCDEIHLYGfwpFPKDLNGKAVKYHYYDD 319
Cdd:cd23984 144 PTTGIIAITLALHICNEVHIAG---FKYDFSNLNSTLHYYGN 182
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 140-320 3.49e-14

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 71.44  E-value: 3.49e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  140 KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRNesdrekfvhRLSMLN 219
Cdd:cd23976  16 KSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRI---LRN---------RNELLN 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  220 DS-----VLWIPA-FMVKGGEKHVewVNALILKNKLkvrtaYPSLRLIHAVRGYWLTNKVPIKRP------------STG 281
Cdd:cd23976  84 VSqgtvfIFWGPSnYMRRDGKGLV--YNNLQLMNQI-----LPKLKVYTITRHKMLQFDELFKREtgkdrkisntwlSTG 156

                       170       180       190       200
                ....*....|....*....|....*....|....*....|.
gi 5031999  282 LLMYTLATRFCDEIHLYGFWP--FPKDLNGKAVKYHYYDDL 320
Cdd:cd23976 157 WFTMIIALELCDRINVYGMVPpdFCRDPNHPSVPYHYYEPS 197
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 140-343 4.34e-14

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 70.54  E-value: 4.34e-14
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  140 KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDfITMN-----PSVVQrafggfrnESDR-EKFVH 213
Cdd:cd23983   3 RRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTT-IRMTypegaPKSEQ--------EYDPtSLFVA 73

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  214 RL----------SMLNDSVL--WIPAFMVKG-------GEKHVEWVNALILKNKLKVRTAYPSLRlihaVRGYWLTNKVp 274
Cdd:cd23983  74 VLfksvdfawlkAMVKKEPLsfWSRLFFWKEvadsiplKPSQFRILNPLIIKETALDILQYPEPQ----SRLWGWDKNV- 148

                       170       180       190       200       210       220
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 5031999  275 ikrPSTGLLMYTLATRFCDEIHLYGfwpFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVL 343
Cdd:cd23983 149 ---PTLGVTAVVLATHLCDEVSLAG---FGYDLSQPHAPLHYYDSVCMAAMNTQTMHNVTKETKFLKKL 211
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 140-321 2.54e-12

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 65.65  E-value: 2.54e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  140 KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRNESdrekfvHRLSMLN 219
Cdd:cd23977   2 RRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLL---LRNQG------YFFQQSR 72

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  220 DSVlwipaFMVKGGEKHVEWVNALILKNKL-KVRTAYPSLRLihavrgYWLT------------NKVPIKRP------ST 280
Cdd:cd23977  73 DTK-----YVIWGPERNMDRDGGGKTYRALlTLAKMYPHLQV------YTLTeekmaycdgvfqNETGKNRMksgsflST 141

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 5031999  281 GLLMYTLATRFCDEIHLYGFW--PFPKDLNGKAVKYHYYDDLK 321
Cdd:cd23977 142 GWFTMILALELCEEILVYGMVsdSYCRNKNHSSVPYHYYEKGR 184
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 131-318 3.11e-12

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 66.01  E-value: 3.11e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  131 VSPMKNRRFKTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAFGGFRNESdrek 210
Cdd:cd23986  41 LSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINSQILTNPNHHFIDSS---- 116

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  211 fVHRLSMLndsVLWIPAFMVKGGEKHVEWVNALILKNKLKVRTAYPS--LRLIHAvRGYW---------LTNKVPIKRPS 279
Cdd:cd23986 117 -LYKDVIL---VAWDPAPYSANLHKWYKKPDYNLFTPYVQYRKRNPNqpFYILHP-KFIWqlwdiiqenTQEKIQPNPPS 191

                       170       180       190       200
                ....*....|....*....|....*....|....*....|...
gi 5031999  280 TGLLMYTLATRFCDEIHLYGFWPFPK--DLngkaVKYH--YYD 318
Cdd:cd23986 192 SGFIGILIMMSMCREVHVYEYIPSVRqtDL----CHYHerYYD 230
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 140-343 7.91e-11

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 61.09  E-value: 7.91e-11
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  140 KTCAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDF-ITMNPSVVQRAfggfrneSDREKfvhrlsml 218
Cdd:cd23981   3 RRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLrITYPEGAIQKP-------EQYEK-------- 67

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  219 nDSVLWIPAFMvkggEKHVEWVNALILKNKLK--------VRTAYPslRLIHAVR---GYWL-----------TNKVPIK 276
Cdd:cd23981  68 -DSLFVLAGFK----WQDFKWLKYIVYKEKVSasdgfwksVATRVP--REPHEIRilnPYFIqeaafsfiglpFNNGLMG 140

                       170       180       190       200       210       220       230
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  277 R---PSTGLLMYTLATRFCDEIHLYGfwpFPKDLNGKAVKYHYYDDLKYRYFSNASPHRMPLEFKTLNVL 343
Cdd:cd23981 141 RgniPTLGSVAITMALHNCDEVAVAG---FGYDMNTPNAPLHYYETIKMSAIKESWTHNIQREKEFLRKL 207
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 142-318 1.57e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 54.48  E-value: 1.57e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  142 CAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSDFITMNPSVVqrafggFRNESDREKFVHRLSmlnDS 221
Cdd:cd23978   4 CALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSV------YRVLRRPQEFLNRTP---ET 74

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  222 VL--W-IPAFMVKGGEKHVewvnALILKnklKVRTAYPSLR--------------LIHAVRG-------YWLtnkvpikr 277
Cdd:cd23978  75 TLifWgPPNKMQKDGKSNL----FRIIQ---RASMTFPNMSafvvsprrmrqfddLFRGETGrdrkkshSWL-------- 139

                       170       180       190       200
                ....*....|....*....|....*....|....*....|....
gi 5031999  278 pSTGLLMYTLATRFCDEIHLYGFWPF---PKDLNGKAVKYHYYD 318
Cdd:cd23978 140 -STGWFTMVIAVELCDNVHVYGMVPPnycSKRPTPKKMPYHYYE 182
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 142-318 5.36e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 53.01  E-value: 5.36e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  142 CAVVGNSGILLDSECGKEIDSHNFVIRCNLAPVVEFAADVGTKSD----------FITMNP--------SVVQRAFGGFR 203
Cdd:cd23975   4 CAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTirvvshtsvpLLLKNPdyffketnETIYVIWGPFR 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 5031999  204 N-ESDREKFVHrlSMLNDSVLWIP-AFMVKGGEKHVEWVNALILKNKLKVRTAypslrlihavRGYWLtnkvpikrpSTG 281
Cdd:cd23975  84 NmRKDGKGIVY--NMLKKAVESYPqAKIYVTTEKRMSYCDTVFKKETGKDRVQ----------SGSYL---------STG 142

                       170       180       190
                ....*....|....*....|....*....|....*....
gi 5031999  282 LLMYTLATRFCDEIHLYGFW--PFPKDLNGKAVKYHYYD 318
Cdd:cd23975 143 WFTLILAMDACYGIHVYGMIndTYCKTEGYRKVPYHYYE 181
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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