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Conserved domains on  [gi|323098348|ref|NP_005690|]
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interleukin-18-binding protein isoform c precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Pox_vIL-18BP super family cl23951
Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory ...
 79-169 5.81e-10

Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Several poxvirus genes encode proteins with sequence similarity to IL-18BPs. It has been shown that vaccinia, ectromelia and cowpox viruses secrete from infected cells a soluble IL-18BP (vIL-18BP) that may modulate the host antiviral response. The expression of vIL-18BPs by distinct poxvirus genera that cause local or general viral dissemination, or persistent or acute infections in the host, emphasizes the importance of IL-18 in response to viral infections.


The actual alignment was detected with superfamily member PHA03112:

Pssm-ID: 305108  Cd Length: 141  Bit Score: 55.09  E-value: 5.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323098348  79 NGTLSLSCVACSRFPNFSILYWL-GNGS------FIEHLPGRLWEGSTSRERGSTGTQLCKalvLEQLTPALHSTNFSCV 151
Cdd:PHA03112  38 TEKVVLECRGCSYFPKFSYVYWLiGNNKsdvdqkPIEHYGEGIYESEKPRTCDNEPRTDLI---VYNVTDEMKFTKLTCV 114

                         90
                 ....*....|....*...
gi 323098348 152 LVDPEQVVQRHVVLAQLW 169
Cdd:PHA03112 115 LMDLDGPIKKSIILNNIW 132
 
Name Accession Description Interval E-value
PHA03112 PHA03112
IL-18 binding protein; Provisional
 79-169 5.81e-10

IL-18 binding protein; Provisional


Pssm-ID: 222990  Cd Length: 141  Bit Score: 55.09  E-value: 5.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323098348  79 NGTLSLSCVACSRFPNFSILYWL-GNGS------FIEHLPGRLWEGSTSRERGSTGTQLCKalvLEQLTPALHSTNFSCV 151
Cdd:PHA03112  38 TEKVVLECRGCSYFPKFSYVYWLiGNNKsdvdqkPIEHYGEGIYESEKPRTCDNEPRTDLI---VYNVTDEMKFTKLTCV 114

                         90
                 ....*....|....*...
gi 323098348 152 LVDPEQVVQRHVVLAQLW 169
Cdd:PHA03112 115 LMDLDGPIKKSIILNNIW 132
Pox_vIL-18BP pfam05566
Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory ...
 66-165 5.13e-04

Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Several poxvirus genes encode proteins with sequence similarity to IL-18BPs. It has been shown that vaccinia, ectromelia and cowpox viruses secrete from infected cells a soluble IL-18BP (vIL-18BP) that may modulate the host antiviral response. The expression of vIL-18BPs by distinct poxvirus genera that cause local or general viral dissemination, or persistent or acute infections in the host, emphasizes the importance of IL-18 in response to viral infections.


Pssm-ID: 283269  Cd Length: 126  Bit Score: 38.49  E-value: 5.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323098348   66 ALEVTWPEVEVpLNGTLSLSCVACSRF-PNFSILYWLG-------NGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLE 137
Cdd:pfam05566  20 ADEIKCPNLDI-VTSSGEFRCSGCVEFmPKFSYMYWLAkdmksdeDAKFIEHLGDGIKEDETIRTIDGGITTLQKVLHVT 98

                          90       100
                  ....*....|....*....|....*...
gi 323098348  138 QlTPALHSTNFSCVLVDPEQVVQRHVVL 165
Cdd:pfam05566  99 D-TNKFAHYRFTCVLTTIDGVSKKNIWL 125
 
Name Accession Description Interval E-value
PHA03112 PHA03112
IL-18 binding protein; Provisional
 79-169 5.81e-10

IL-18 binding protein; Provisional


Pssm-ID: 222990  Cd Length: 141  Bit Score: 55.09  E-value: 5.81e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323098348  79 NGTLSLSCVACSRFPNFSILYWL-GNGS------FIEHLPGRLWEGSTSRERGSTGTQLCKalvLEQLTPALHSTNFSCV 151
Cdd:PHA03112  38 TEKVVLECRGCSYFPKFSYVYWLiGNNKsdvdqkPIEHYGEGIYESEKPRTCDNEPRTDLI---VYNVTDEMKFTKLTCV 114

                         90
                 ....*....|....*...
gi 323098348 152 LVDPEQVVQRHVVLAQLW 169
Cdd:PHA03112 115 LMDLDGPIKKSIILNNIW 132
Pox_vIL-18BP pfam05566
Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory ...
 66-165 5.13e-04

Orthopoxvirus interleukin 18 binding protein; Interleukin-18 (IL-18) is a proinflammatory cytokine that plays a key role in the activation of natural killer and T helper 1 cell responses principally by inducing interferon-gamma (IFN-gamma). Several poxvirus genes encode proteins with sequence similarity to IL-18BPs. It has been shown that vaccinia, ectromelia and cowpox viruses secrete from infected cells a soluble IL-18BP (vIL-18BP) that may modulate the host antiviral response. The expression of vIL-18BPs by distinct poxvirus genera that cause local or general viral dissemination, or persistent or acute infections in the host, emphasizes the importance of IL-18 in response to viral infections.


Pssm-ID: 283269  Cd Length: 126  Bit Score: 38.49  E-value: 5.13e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 323098348   66 ALEVTWPEVEVpLNGTLSLSCVACSRF-PNFSILYWLG-------NGSFIEHLPGRLWEGSTSRERGSTGTQLCKALVLE 137
Cdd:pfam05566  20 ADEIKCPNLDI-VTSSGEFRCSGCVEFmPKFSYMYWLAkdmksdeDAKFIEHLGDGIKEDETIRTIDGGITTLQKVLHVT 98

                          90       100
                  ....*....|....*....|....*...
gi 323098348  138 QlTPALHSTNFSCVLVDPEQVVQRHVVL 165
Cdd:pfam05566  99 D-TNKFAHYRFTCVLTTIDGVSKKNIWL 125
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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