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Conserved domains on  [gi|37574603|ref|NP_005764|]
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zinc finger protein 256 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-54 3.24e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 3.24e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 37574603    14 VTFEDVAVYFSWKEWGLLDEAQKCLYHDVMLENLTLTTSLG 54
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-626 1.35e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.35e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 293 RPHQCDECGKLFNRKYDLLIHQRVHTGERPYKCS--ECGKSFSHSSSLITHQRIHTGMRPYECSECGKS--FIHSSSLIT 368
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 369 HQRVHTgtrPYMCSECGKSFSQSchlIKHRRLHIGEGPYECSECGKLFTYRSRFFQHQRVHTGVrSHECHECGKLFSRKF 448
Cdd:COG5048 112 SSSSNS---NDNNLLSSHSLPPS---SRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP-PLPANSLSKDPSSNL 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 449 DLIVHERVHTGERPYECSECGKSFTCKSYLISHWKVHTGARPYECGECGKSFTHSSTLLQHQRVHTGERPYECNECGKFF 528
Cdd:COG5048 185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 529 SQSSSLIRHRRSHTGER-------PYECSECWKSFSNHSSLVKHRR--VHTGE--RPYECSE--CGKSFSQSSNLTNHQR 595
Cdd:COG5048 265 LPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                       330       340       350
                ....*....|....*....|....*....|...
gi 37574603 596 IHSGERPYEC--SDCGKFFTFNSNLLKHQNVHK 626
Cdd:COG5048 345 LHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQ 377
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-54 3.24e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 3.24e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 37574603    14 VTFEDVAVYFSWKEWGLLDEAQKCLYHDVMLENLTLTTSLG 54
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
14-54 1.73e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 1.73e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 37574603     14 VTFEDVAVYFSWKEWGLLDEAQKCLYHDVMLENLTLTTSLG 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-53 1.46e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 1.46e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 37574603  14 VTFEDVAVYFSWKEWGLLDEAQKCLYHDVMLENLTLTTSL 53
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-626 1.35e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.35e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 293 RPHQCDECGKLFNRKYDLLIHQRVHTGERPYKCS--ECGKSFSHSSSLITHQRIHTGMRPYECSECGKS--FIHSSSLIT 368
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 369 HQRVHTgtrPYMCSECGKSFSQSchlIKHRRLHIGEGPYECSECGKLFTYRSRFFQHQRVHTGVrSHECHECGKLFSRKF 448
Cdd:COG5048 112 SSSSNS---NDNNLLSSHSLPPS---SRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP-PLPANSLSKDPSSNL 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 449 DLIVHERVHTGERPYECSECGKSFTCKSYLISHWKVHTGARPYECGECGKSFTHSSTLLQHQRVHTGERPYECNECGKFF 528
Cdd:COG5048 185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 529 SQSSSLIRHRRSHTGER-------PYECSECWKSFSNHSSLVKHRR--VHTGE--RPYECSE--CGKSFSQSSNLTNHQR 595
Cdd:COG5048 265 LPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                       330       340       350
                ....*....|....*....|....*....|...
gi 37574603 596 IHSGERPYEC--SDCGKFFTFNSNLLKHQNVHK 626
Cdd:COG5048 345 LHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQ 377
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 575-597 1.75e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.75e-03
                          10        20
                  ....*....|....*....|...
gi 37574603   575 YECSECGKSFSQSSNLTNHQRIH 597
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 14-54 3.24e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 3.24e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 37574603    14 VTFEDVAVYFSWKEWGLLDEAQKCLYHDVMLENLTLTTSLG 54
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
14-54 1.73e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 1.73e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 37574603     14 VTFEDVAVYFSWKEWGLLDEAQKCLYHDVMLENLTLTTSLG 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLG 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 14-53 1.46e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.35  E-value: 1.46e-16
                        10        20        30        40
                ....*....|....*....|....*....|....*....|
gi 37574603  14 VTFEDVAVYFSWKEWGLLDEAQKCLYHDVMLENLTLTTSL 53
Cdd:cd07765   1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
293-626 1.35e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.11  E-value: 1.35e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 293 RPHQCDECGKLFNRKYDLLIHQRVHTGERPYKCS--ECGKSFSHSSSLITHQRIHTGMRPYECSECGKS--FIHSSSLIT 368
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnSKASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 369 HQRVHTgtrPYMCSECGKSFSQSchlIKHRRLHIGEGPYECSECGKLFTYRSRFFQHQRVHTGVrSHECHECGKLFSRKF 448
Cdd:COG5048 112 SSSSNS---NDNNLLSSHSLPPS---SRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHP-PLPANSLSKDPSSNL 184

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 449 DLIVHERVHTGERPYECSECGKSFTCKSYLISHWKVHTGARPYECGECGKSFTHSSTLLQHQRVHTGERPYECNECGKFF 528
Cdd:COG5048 185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSS 264

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 529 SQSSSLIRHRRSHTGER-------PYECSECWKSFSNHSSLVKHRR--VHTGE--RPYECSE--CGKSFSQSSNLTNHQR 595
Cdd:COG5048 265 LPTASSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                       330       340       350
                ....*....|....*....|....*....|...
gi 37574603 596 IHSGERPYEC--SDCGKFFTFNSNLLKHQNVHK 626
Cdd:COG5048 345 LHTSISPAKEklLNSSSKFSPLLNNEPPQSLQQ 377
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
237-612 3.45e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 3.45e-12
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 237 RSYMCSECGKSFSTSCSLSDHLRVHTSEKPYTCG--ECGKSYRQSSSLITHRRIHTGVRPHQCDECGKLFN--RKYDLLI 312
Cdd:COG5048  32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNskASSSSLS 111

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 313 HQRVHTgERPYKCSECGKSFSHSSSLITHQRIHTGMRPYECSECGKSFIHSS----------------------SLITHQ 370
Cdd:COG5048 112 SSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPqsnslhpplpanslskdpssnlSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 371 RVHTGTRPYMCSECGKSFSQSCHLIKHRRLHIGEGPYECSECGKLFTYRSRFFQHQRVHTGVRSHECHECGKLF--SRKF 448
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSlpTASS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 449 DLIVHERVHTGER-----PYECSECGKSFTCKSYLISH--WKVHTG--ARPYECGE--CGKSFTHSSTLLQHQRVHTGER 517
Cdd:COG5048 271 QSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHlrSVNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 518 PYEC--NECGKFFSQSS-----SLIRHRRSHTGERPYEC--SECWKSFSNHSSLVKHRRVHTGERPYEC--SECGKSFSQ 586
Cdd:COG5048 351 PAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNR 430

                       410       420
                ....*....|....*....|....*.
gi 37574603 587 SSNLTNHQRIHSGERPYECSDCGKFF 612
Cdd:COG5048 431 HYNLIPHKKIHTNHAPLLCSILKSFR 456
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-532 2.90e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 56.63  E-value: 2.90e-08
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 280 SSLITHRRIHTGVRPHQCDECGKLFNRKYDLLIHQRVHTGERPYKCSECGKSFSHSSSLITHQRIHTgmrPYECSECGKS 359
Cdd:COG5048 184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSS---SDSSSSASES 260

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 360 FIHSSSLITHQR---------VHTG-TRPYMCSECGKSFSQSCHLIKHRR--LHIGEG--PYECSE--CGKLFTYRSRFF 423
Cdd:COG5048 261 PRSSLPTASSQSsspnesdssSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESlkPFSCPYslCGKLFSRNDALK 340

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 424 QHQRVHTGVRSHECHEC-------GKLFSRKFDLIVHERVHTGERPYEC--SECGKSFTCKSYLISHWKVHTGARPYEC- 493
Cdd:COG5048 341 RHILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCk 420

                       250       260       270       280
                ....*....|....*....|....*....|....*....|
gi 37574603 494 -GECGKSFTHSSTLLQHQRVHTGERPYECNECGKFFSQSS 532
Cdd:COG5048 421 nPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
238-391 1.35e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.24  E-value: 1.35e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 238 SYMCSECGKSFSTSCSLSDHLR--VHTSE--KPYTCGE--CGKSYRQSSSLITHRRIHTGVRPHQC--DECGKLFNRKYD 309
Cdd:COG5048 289 PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLLN 368

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 310 LLIHQRVH-----TGERPYKC--SECGKSFSHSSSLITHQRIHTGMRPYEC--SECGKSFIHSSSLITHQRVHTGTRPYM 380
Cdd:COG5048 369 NEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                       170
                ....*....|.
gi 37574603 381 CSECGKSFSQS 391
Cdd:COG5048 449 CSILKSFRRDL 459
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
62-477 4.37e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 4.37e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603  62 EAPYQQSTSPQRVSQV--RIPKALPSPQKTNPCEICGPVLRQILHLVEHQGTHHGQKLY--TDGACRKQLQFTAYLHQHQ 137
Cdd:COG5048   4 TSSQSSSSNNSVLSSTpkSTLKSLSNAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSqcSYSGCDKSFSRPLELSRHL 83

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 138 KQHVGQKHFR-SNGGRDMFLSSCTFEVSGKPFT------------CKEVGKDFL--VRSRFLQQQAAHTRKKSNRTKSAV 202
Cdd:COG5048  84 RTHHNNPSDLnSKSLPLSNSKASSSSLSSSSSNsndnnllsshslPPSSRDPQLpdLLSISNLRNNPLPGNNSSSVNTPQ 163

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 203 AFHSVKNHYNWGECVKAFSYKHVRVQHQGDLIRERSYMCSECGKSFSTSCSLSDHLRVHTSEkPYTCGECGKSYRQSSSL 282
Cdd:COG5048 164 SNSLHPPLPANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLS 242

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 283 ITHRRIHTGVRPHQCDECGKLF--NRKYDLLIHQRVHTGER-----PYKCSECGKSFSHSSSLITHQR--IHTGM--RPY 351
Cdd:COG5048 243 QSPSSLSSSDSSSSASESPRSSlpTASSQSSSPNESDSSSEkgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPF 322

                       330       340       350       360       370       380       390       400
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 352 ECSE--CGKSFIHSSSLITHQRVHTGTRPYMC--SECGKSFSQS------CHLIKHRRLHIgEGPYECSECGKLFTYRSR 421
Cdd:COG5048 323 SCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKN-DKKSETLSNSCIRNFKRD 401

                       410       420       430       440       450       460
                ....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 422 FFQ--HQRVHTGVRSHECH--ECGKLFSRKFDLIVHERVHTGERPYECSECGKSFTCKSY 477
Cdd:COG5048 402 SNLslHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
348-625 4.53e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 4.53e-06
                        10        20        30        40        50        60        70        80
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 348 MRPYECSECGKSFIHSSSLITHQRVHTGTRPYMCS--ECGKSFSQSCHLIKHRRLHIGEGPYECSECGKLFTYRSRFFQH 425
Cdd:COG5048  31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSL 110

                        90       100       110       120       130       140       150       160
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 426 QRVHTGVRSHE-CHECGKLFSRKFDLIVHERVHTGERPYECSECGKSF----------------------TCKSYLISHW 482
Cdd:COG5048 111 SSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpanslskdpSSNLSLLISS 190

                       170       180       190       200       210       220       230       240
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 483 KVHTGARPYECGECGKSFTHSSTLLQHQRVHTGERPYECNECGKFF-------SQSSSLIRHRRSHTGERPYEC----SE 551
Cdd:COG5048 191 NVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpksllsqSPSSLSSSDSSSSASESPRSSlptaSS 270

                       250       260       270       280       290       300       310       320
                ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 37574603 552 CWKSFSNHSSlVKHRRVHTgerPYECSECGKSFSQSSNLTNHQR--IHSGE--RPYEC--SDCGKFFTFNSNLLKHQNVH 625
Cdd:COG5048 271 QSSSPNESDS-SSEKGFSL---PIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLH 346
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 575-597 1.75e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.12  E-value: 1.75e-03
                          10        20
                  ....*....|....*....|...
gi 37574603   575 YECSECGKSFSQSSNLTNHQRIH 597
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
561-586 2.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 37574603   561 SLVKHRRVHTGERPYECSECGKSFSQ 586
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 323-345 2.91e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 35.35  E-value: 2.91e-03
                          10        20
                  ....*....|....*....|...
gi 37574603   323 YKCSECGKSFSHSSSLITHQRIH 345
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-334 2.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.92e-03
                          10        20
                  ....*....|....*....|....*.
gi 37574603   309 DLLIHQRVHTGERPYKCSECGKSFSH 334
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
449-474 3.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.35e-03
                          10        20
                  ....*....|....*....|....*.
gi 37574603   449 DLIVHERVHTGERPYECSECGKSFTC 474
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
506-530 4.08e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.08e-03
                          10        20
                  ....*....|....*....|....*
gi 37574603   506 LLQHQRVHTGERPYECNECGKFFSQ 530
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 519-541 6.97e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.20  E-value: 6.97e-03
                          10        20
                  ....*....|....*....|...
gi 37574603   519 YECNECGKFFSQSSSLIRHRRSH 541
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-362 7.29e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.29e-03
                          10        20
                  ....*....|....*....|....*.
gi 37574603   337 SLITHQRIHTGMRPYECSECGKSFIH 362
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
589-613 9.70e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.70e-03
                          10        20
                  ....*....|....*....|....*
gi 37574603   589 NLTNHQRIHSGERPYECSDCGKFFT 613
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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