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isocitrate dehydrogenase [NADP] cytoplasmic [Homo sapiens]
Protein Classification
NADP-dependent isocitrate dehydrogenase ( domain architecture ID 10015366 )
NADP-dependent isocitrate dehydrogenase catalyzes the conversion of isocitrate to 2-oxoglutarate in an NADP-dependent manner
List of domain hits
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-411
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 847.35
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 1 MSK KI S - GGS VVE MQ GDEMTRIIW EL IKEKLI F PY VELDLHS YDL G IENRD A T N D Q VT K DAAEAIKKH N VG V KCATITPD 79
Cdd:PTZ00435 2 TGG KI K v KNP VVE LD GDEMTRIIW KM IKEKLI L PY LDVPIKY YDL S IENRD K T D D K VT V DAAEAIKKH K VG I KCATITPD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 80 E K RV E EF K LK Q MWKSPNGTIRNIL G GTVFRE A II C KNIPRLV S GW V KPI I IGRHA Y GDQY R ATDFVV P GPGK V E ITY TP S 159
Cdd:PTZ00435 82 E A RV K EF N LK K MWKSPNGTIRNIL D GTVFRE P II I KNIPRLV P GW K KPI V IGRHA F GDQY K ATDFVV D GPGK L E LVF TP A 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 160 DG TQKVTYL V HN F E e GGGVAMGMYN Q D K SIE D FA H S S FQ M AL SKGW PLYLSTKNTILKKYDGRFKDIFQEIYD KQ YK SQ F 239
Cdd:PTZ00435 162 DG SEPQRVD V FD F K - GGGVAMGMYN T D E SIE G FA R S C FQ Y AL DRKM PLYLSTKNTILKKYDGRFKDIFQEIYD EE YK AK F 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 240 E AQKI WYEHRLIDDMVAQA M KSEGGF I WACKNYDGDVQSD S VAQGYGSLG M MTSVLVCPDGKTVEAEAAHGTVTRHYR MY 319
Cdd:PTZ00435 241 E KAGL WYEHRLIDDMVAQA I KSEGGF V WACKNYDGDVQSD I VAQGYGSLG L MTSVLVCPDGKTVEAEAAHGTVTRHYR QH 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 320 QKG Q ETSTN P IASIFAWTRGLAHRAKLDNN K EL AF F AN ALE EVS IETIEAGFMTKDLA A C IK G LPN V Q RSDYLNT F EF M D 399
Cdd:PTZ00435 321 QKG K ETSTN S IASIFAWTRGLAHRAKLDNN Q EL VK F CQ ALE RSC IETIEAGFMTKDLA I C VH G SSK V T RSDYLNT E EF I D 400
410
....*....|..
gi 28178825 400 K LG E N LK I KL AQ 411
Cdd:PTZ00435 401 K VA E K LK K KL GA 412
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-411
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 847.35
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 1 MSK KI S - GGS VVE MQ GDEMTRIIW EL IKEKLI F PY VELDLHS YDL G IENRD A T N D Q VT K DAAEAIKKH N VG V KCATITPD 79
Cdd:PTZ00435 2 TGG KI K v KNP VVE LD GDEMTRIIW KM IKEKLI L PY LDVPIKY YDL S IENRD K T D D K VT V DAAEAIKKH K VG I KCATITPD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 80 E K RV E EF K LK Q MWKSPNGTIRNIL G GTVFRE A II C KNIPRLV S GW V KPI I IGRHA Y GDQY R ATDFVV P GPGK V E ITY TP S 159
Cdd:PTZ00435 82 E A RV K EF N LK K MWKSPNGTIRNIL D GTVFRE P II I KNIPRLV P GW K KPI V IGRHA F GDQY K ATDFVV D GPGK L E LVF TP A 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 160 DG TQKVTYL V HN F E e GGGVAMGMYN Q D K SIE D FA H S S FQ M AL SKGW PLYLSTKNTILKKYDGRFKDIFQEIYD KQ YK SQ F 239
Cdd:PTZ00435 162 DG SEPQRVD V FD F K - GGGVAMGMYN T D E SIE G FA R S C FQ Y AL DRKM PLYLSTKNTILKKYDGRFKDIFQEIYD EE YK AK F 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 240 E AQKI WYEHRLIDDMVAQA M KSEGGF I WACKNYDGDVQSD S VAQGYGSLG M MTSVLVCPDGKTVEAEAAHGTVTRHYR MY 319
Cdd:PTZ00435 241 E KAGL WYEHRLIDDMVAQA I KSEGGF V WACKNYDGDVQSD I VAQGYGSLG L MTSVLVCPDGKTVEAEAAHGTVTRHYR QH 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 320 QKG Q ETSTN P IASIFAWTRGLAHRAKLDNN K EL AF F AN ALE EVS IETIEAGFMTKDLA A C IK G LPN V Q RSDYLNT F EF M D 399
Cdd:PTZ00435 321 QKG K ETSTN S IASIFAWTRGLAHRAKLDNN Q EL VK F CQ ALE RSC IETIEAGFMTKDLA I C VH G SSK V T RSDYLNT E EF I D 400
410
....*....|..
gi 28178825 400 K LG E N LK I KL AQ 411
Cdd:PTZ00435 401 K VA E K LK K KL GA 412
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
3-411
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 787.91
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 3 K KI SGGS - VVEM Q GDEMTRIIWELIK E KLI F PYVELDL HS YDLG I E N RDATNDQVT K DAAEAIKK H NVGVKCATITPDE K 81
Cdd:TIGR00127 1 S KI KVAN p VVEM D GDEMTRIIWELIK D KLI L PYVELDL KY YDLG V E Y RDATNDQVT V DAAEAIKK Y NVGVKCATITPDE A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 82 RVEEFKLK Q MWKSPNGTIRNILGGTVFRE A IICKNIPRLV S GW V KPIIIGRHA Y GDQYRATDFVVPGPGK V E IT Y T P S DG 161
Cdd:TIGR00127 81 RVEEFKLK K MWKSPNGTIRNILGGTVFRE P IICKNIPRLV P GW E KPIIIGRHA F GDQYRATDFVVPGPGK L E LV Y K P K DG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 162 TQKVT YL V HN FEEGGGVAM G MYN Q D K SIE D FAHSSFQ M AL S K G WPLYLSTKNTILKKYDGRFKDIFQE I Y DK QYKS Q FEA 241
Cdd:TIGR00127 161 TQKVT LK V YD FEEGGGVAM A MYN T D E SIE G FAHSSFQ L AL E K K WPLYLSTKNTILKKYDGRFKDIFQE V Y EA QYKS K FEA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 242 QK IWYEHRLIDDMVAQA M KSEGGFIWACKNYDGDVQSD S VAQG Y GSLG M MTSVL V CPDGKT V EAEAAHGTVTRHYRMYQK 321
Cdd:TIGR00127 241 LG IWYEHRLIDDMVAQA L KSEGGFIWACKNYDGDVQSD I VAQG F GSLG L MTSVL I CPDGKT F EAEAAHGTVTRHYRMYQK 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 322 GQETSTN P IASIFAW T RGLAHRAKLDNN K EL AF FAN A LE EVS I E T I EAG F MTKDLA ACIK G L P n V Q RS D YLNT F EF M D KL 401
Cdd:TIGR00127 321 GQETSTN S IASIFAW S RGLAHRAKLDNN P EL SK FAN I LE SAC I N T V EAG I MTKDLA LILG G S P - V E RS A YLNT E EF I D AV 399
410
....*....|
gi 28178825 402 G E N LK I K L A Q 411
Cdd:TIGR00127 400 E E R LK K K I A A 409
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
10-406
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 509.65
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 10 VVEMQ GD ---- E M TR I IW EL I KEKLIFP Y --- VELDLHSY D L G IEN RD A T N D QVTKDA AEAIK KHN VG V K CATI TP DE kr 82
Cdd:COG0538 21 IPFIE GD gigp E I TR A IW KV I DAAVEKA Y ggk RDIEWKEV D A G EKA RD E T G D WLPDET AEAIK EYG VG I K GPLT TP VG -- 98
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 83 veefklk QM W K S P N G TIR N IL GGT V F R EAI - IC K NI P RL V SGWV K - P I I I G R HAYG D Q Y RATDFVVPG P GKVEITYTPS D 160
Cdd:COG0538 99 ------- GG W R S L N V TIR Q IL DLY V C R RPV r YF K GV P SP V KHPE K v D I V I F R ENTE D I Y AGIEWKAGS P EALKLIFFLE D 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 161 GT qkv TYL V HN F E E GG G VAMGMYN q D KSI E DFAHSSF Q M AL SKG - WPLY L ST K NT I L K KYD G R FKD IFQ E IYDKQYKSQ F 239
Cdd:COG0538 172 EM --- GVT V IR F P E DS G IGIKPVS - D EGT E RLVRAAI Q Y AL DNK r KSVT L VH K GN I M K FTE G A FKD WGY E VAEEEFGDK F 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 240 ------------- E A Q KI W Y EH R LI DDM VA Q AMKSE G G - FIW A C KN YD GD VQ SD SV A QGY G S LG MMTSVLVCP DG K t V E A 305
Cdd:COG0538 248 itegpwekykgpk P A G KI V Y KD R IA DDM LQ Q ILLRP G E y DVI A T KN LN GD YI SD AL A AQV G G LG IAPGANIGD DG G - A E F 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 306 EA A HGT VTRH yrmyqk GQET STNP IAS I FAW T RG L A HR AK L DN nkelaff A NAL E EVSIE TIE A G FM T K DLA ACIK G LP n 385
Cdd:COG0538 327 EA T HGT APKY ------ AGKD STNP GSL I LSG T MM L R HR GW L EA ------- A DLI E KAVEK TIE S G KV T Y DLA RLME G AT - 392
410 420
....*....|....*....|.
gi 28178825 386 vqrsd Y L N T F EF M D KLG ENL K 406
Cdd:COG0538 393 ----- E L S T S EF G D AII ENL D 408
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
11-401
1.33e-86
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 267.24
E-value: 1.33e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 11 VEMQ G D E MTRIIWELI K EK L IFPYV E LDLHSY D L G IENR D A T NDQVTKDAA EA I KK HNVGVKC A TIT P D ---- EK R V E EF 86
Cdd:pfam00180 7 GDGI G P E VMAAALKVL K AA L EKAPL E FEFEER D V G GAAI D E T GEPLPDETL EA C KK ADAVLLG A VGG P K wdpa GV R P E NG 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 87 k L KQMW K SP n G TIR N ILGGT VF R e AIICKNIPRLVSGW V K p I I I G R HAY G DQ Y RATDFVVP G P G kveitytpsdgtqkvt 166
Cdd:pfam00180 87 - L LALR K EL - G LFA N LRPAK VF P - PLGDASPLKNEVEG V D - I V I V R ELT G GI Y FGIEKGIK G S G ---------------- 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 167 ylvhnfe EGGG V AMGM Y NQ D K s IE DF A HSS F QM A LSK G - WPLYLST K NTI LK KY D g RFKD I FQ E IYDKQ Y K sqfeaq KIW 245
Cdd:pfam00180 147 ------- NEVA V DTKL Y SR D E - IE RI A RVA F EL A RKR G r KKVTSVD K ANV LK SS D - LWRK I VT E VAKAE Y P ------ DVE 211
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 246 Y EH R L I D DMVA Q AM K SEGG F - IWACK N YD GD VQ SD SVAQGY GSLG MMT S VLVCPD G k TVEA E AA HG TVTRHYR myq KG Q e 324
Cdd:pfam00180 212 L EH Q L V D NAAM Q LV K NPSQ F d VIVTP N LF GD IL SD EASMLT GSLG LLP S ASLGAN G - FGIF E PV HG SAPDIAG --- KG I - 286
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28178825 325 ts T NPIA S I FAWTRG L AHRAK L DNN kelaff A NAL E EVSIETI E A G FM T K DLA A cikglpnvq RSD Y LN T F EF MDKL 401
Cdd:pfam00180 287 -- A NPIA T I LSAAMM L RYSLG L EDA ------ A DKI E AAVLKVL E S G IR T G DLA G --------- SAT Y VS T S EF GEAV 346
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-411
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 847.35
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 1 MSK KI S - GGS VVE MQ GDEMTRIIW EL IKEKLI F PY VELDLHS YDL G IENRD A T N D Q VT K DAAEAIKKH N VG V KCATITPD 79
Cdd:PTZ00435 2 TGG KI K v KNP VVE LD GDEMTRIIW KM IKEKLI L PY LDVPIKY YDL S IENRD K T D D K VT V DAAEAIKKH K VG I KCATITPD 81
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 80 E K RV E EF K LK Q MWKSPNGTIRNIL G GTVFRE A II C KNIPRLV S GW V KPI I IGRHA Y GDQY R ATDFVV P GPGK V E ITY TP S 159
Cdd:PTZ00435 82 E A RV K EF N LK K MWKSPNGTIRNIL D GTVFRE P II I KNIPRLV P GW K KPI V IGRHA F GDQY K ATDFVV D GPGK L E LVF TP A 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 160 DG TQKVTYL V HN F E e GGGVAMGMYN Q D K SIE D FA H S S FQ M AL SKGW PLYLSTKNTILKKYDGRFKDIFQEIYD KQ YK SQ F 239
Cdd:PTZ00435 162 DG SEPQRVD V FD F K - GGGVAMGMYN T D E SIE G FA R S C FQ Y AL DRKM PLYLSTKNTILKKYDGRFKDIFQEIYD EE YK AK F 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 240 E AQKI WYEHRLIDDMVAQA M KSEGGF I WACKNYDGDVQSD S VAQGYGSLG M MTSVLVCPDGKTVEAEAAHGTVTRHYR MY 319
Cdd:PTZ00435 241 E KAGL WYEHRLIDDMVAQA I KSEGGF V WACKNYDGDVQSD I VAQGYGSLG L MTSVLVCPDGKTVEAEAAHGTVTRHYR QH 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 320 QKG Q ETSTN P IASIFAWTRGLAHRAKLDNN K EL AF F AN ALE EVS IETIEAGFMTKDLA A C IK G LPN V Q RSDYLNT F EF M D 399
Cdd:PTZ00435 321 QKG K ETSTN S IASIFAWTRGLAHRAKLDNN Q EL VK F CQ ALE RSC IETIEAGFMTKDLA I C VH G SSK V T RSDYLNT E EF I D 400
410
....*....|..
gi 28178825 400 K LG E N LK I KL AQ 411
Cdd:PTZ00435 401 K VA E K LK K KL GA 412
PRK08299
PRK08299 NADP-dependent isocitrate dehydrogenase;
1-409
0e+00
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226
Cd Length: 402
Bit Score: 821.02
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 1 M S K KISGGS VVE MQ GDEMTRIIW EL IK E KLI F PY VEL DL HS YDLGIENRDAT N DQVT K DAA E AIKK HN VGVKCATITPDE 80
Cdd:PRK08299 1 M A K IKVKNP VVE LD GDEMTRIIW KF IK D KLI L PY LDI DL EY YDLGIENRDAT D DQVT I DAA N AIKK YG VGVKCATITPDE 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 81 K RV E EF K LK Q MWKSPNGTIRNILGGTVFRE A IICKN I PRLV S GW V KPI I IGRHAYGDQYRATDF V VPG P GK VEITY T PS D 160
Cdd:PRK08299 81 A RV K EF N LK K MWKSPNGTIRNILGGTVFRE P IICKN V PRLV P GW T KPI V IGRHAYGDQYRATDF K VPG K GK LTLVF T GE D 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 161 G t QKVTYL VH N F E e G G GVAMGMYN Q D K SI E DFA HS SF QMA L SKGW P L YLSTKNTILK K YDGRFKDIFQE I Y DKQY K SQ FE 240
Cdd:PRK08299 161 G - EPIEHE VH D F P - G A GVAMGMYN L D E SI R DFA RA SF NYG L DRKY P V YLSTKNTILK A YDGRFKDIFQE V Y EAEF K EK FE 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 241 A QK I W YEHRLIDDMVA Q A M K S EGG FI WACKNYDGDVQSD S VAQG Y GSLG M MTSVL VC PDGKTVEAEAAHGTVTRHYR MY Q 320
Cdd:PRK08299 239 A AG I T YEHRLIDDMVA S A L K W EGG YV WACKNYDGDVQSD T VAQG F GSLG L MTSVL MT PDGKTVEAEAAHGTVTRHYR QH Q 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 321 KG Q ETSTNPIASIFAWTRGLAHR A KLD N N K EL AF FA NA LE E V S IET I E A GFMTKDLA ACIK gl P NVQ rsd Y L N T F EF M D K 400
Cdd:PRK08299 319 KG E ETSTNPIASIFAWTRGLAHR G KLD G N P EL VK FA DT LE K V C IET V E S GFMTKDLA LLVG -- P DQK --- W L T T E EF L D A 393
....*....
gi 28178825 401 LG ENL KIK L 409
Cdd:PRK08299 394 ID ENL EKA L 402
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
3-411
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 787.91
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 3 K KI SGGS - VVEM Q GDEMTRIIWELIK E KLI F PYVELDL HS YDLG I E N RDATNDQVT K DAAEAIKK H NVGVKCATITPDE K 81
Cdd:TIGR00127 1 S KI KVAN p VVEM D GDEMTRIIWELIK D KLI L PYVELDL KY YDLG V E Y RDATNDQVT V DAAEAIKK Y NVGVKCATITPDE A 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 82 RVEEFKLK Q MWKSPNGTIRNILGGTVFRE A IICKNIPRLV S GW V KPIIIGRHA Y GDQYRATDFVVPGPGK V E IT Y T P S DG 161
Cdd:TIGR00127 81 RVEEFKLK K MWKSPNGTIRNILGGTVFRE P IICKNIPRLV P GW E KPIIIGRHA F GDQYRATDFVVPGPGK L E LV Y K P K DG 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 162 TQKVT YL V HN FEEGGGVAM G MYN Q D K SIE D FAHSSFQ M AL S K G WPLYLSTKNTILKKYDGRFKDIFQE I Y DK QYKS Q FEA 241
Cdd:TIGR00127 161 TQKVT LK V YD FEEGGGVAM A MYN T D E SIE G FAHSSFQ L AL E K K WPLYLSTKNTILKKYDGRFKDIFQE V Y EA QYKS K FEA 240
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 242 QK IWYEHRLIDDMVAQA M KSEGGFIWACKNYDGDVQSD S VAQG Y GSLG M MTSVL V CPDGKT V EAEAAHGTVTRHYRMYQK 321
Cdd:TIGR00127 241 LG IWYEHRLIDDMVAQA L KSEGGFIWACKNYDGDVQSD I VAQG F GSLG L MTSVL I CPDGKT F EAEAAHGTVTRHYRMYQK 320
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 322 GQETSTN P IASIFAW T RGLAHRAKLDNN K EL AF FAN A LE EVS I E T I EAG F MTKDLA ACIK G L P n V Q RS D YLNT F EF M D KL 401
Cdd:TIGR00127 321 GQETSTN S IASIFAW S RGLAHRAKLDNN P EL SK FAN I LE SAC I N T V EAG I MTKDLA LILG G S P - V E RS A YLNT E EF I D AV 399
410
....*....|
gi 28178825 402 G E N LK I K L A Q 411
Cdd:TIGR00127 400 E E R LK K K I A A 409
PLN03065
PLN03065 isocitrate dehydrogenase (NADP+); Provisional
10-414
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 178617 [Multi-domain]
Cd Length: 483
Bit Score: 723.98
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 10 V VEM Q GDEMTR I IW EL IK E KLIFPY VE LD LHSY DLGI E NRDAT N D Q VT KDA AEA IK K H NV GV KCATITPDE K RV E EF K LK 89
Cdd:PLN03065 80 I VEM D GDEMTR V IW QM IK D KLIFPY LD LD IKYF DLGI L NRDAT D D K VT VES AEA TL K Y NV AI KCATITPDE A RV K EF G LK 159
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 90 Q MW K SPNGTIRNIL G GTVFRE A I I CKNIPRLV S GW V KPI I IGRHA Y GDQYRATD F V VP GPGK VEITYT P S DG TQK V TYL V 169
Cdd:PLN03065 160 S MW R SPNGTIRNIL N GTVFRE P I L CKNIPRLV P GW K KPI C IGRHA F GDQYRATD T V IK GPGK LKMVFV P E DG NAP V ELD V 239
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 170 HN F E e G G GVA MG MYN Q D K SI ED FA H SS FQ MAL S K G WPLYLSTKNTILKKYDGRFKDIFQE I Y DK Q Y K SQ FE AQK IWYEHR 249
Cdd:PLN03065 240 YD F K - G P GVA LA MYN V D E SI RA FA E SS MA MAL Q K K WPLYLSTKNTILKKYDGRFKDIFQE V Y EE Q W K QK FE EHS IWYEHR 318
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 250 LIDDMVA Q A M KSEGG FI WACKNYDGDVQSD SV AQG Y GSLG M MTSVL VCP DGKT V EAEAAHGTVTRH Y R MY QKGQETSTN P 329
Cdd:PLN03065 319 LIDDMVA Y A V KSEGG YV WACKNYDGDVQSD LL AQG F GSLG L MTSVL LSS DGKT L EAEAAHGTVTRH F R LH QKGQETSTN S 398
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 330 IASIFAWTRGL A HRAKLD N N K EL AF F ANA LE EVS IET I E A G F MTKDLA AC I K G l P N V Q R SD YLNT F EF M D KLGEN L KI K L 409
Cdd:PLN03065 399 IASIFAWTRGL E HRAKLD K N E EL LD F VHK LE SAC IET V E S G K MTKDLA IL I H G - P K V S R EF YLNT E EF I D AVAQT L AT K R 477
....*
gi 28178825 410 AQAKL 414
Cdd:PLN03065 478 GEPAV 482
PLN00103
PLN00103 isocitrate dehydrogenase (NADP+); Provisional
10-409
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177720
Cd Length: 410
Bit Score: 695.81
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 10 V VEM Q GDEMTR I IW EL IK E KLIFP YVE LD LHSY DLG IE NRDAT N D Q VT KDA AEA IK K H NV GV KCATITPDE K RV E EF K LK 89
Cdd:PLN00103 12 I VEM D GDEMTR V IW KS IK D KLIFP FLD LD IKYF DLG LP NRDAT D D K VT VES AEA TL K Y NV AI KCATITPDE A RV K EF G LK 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 90 QMWKSPNGTIRNIL G GTVFRE A IICKNIPRLV S GW V KPI I IGRHA Y GDQYRATD F V VP GPGK VEITYT P SDGTQ K VTYL V 169
Cdd:PLN00103 92 QMWKSPNGTIRNIL N GTVFRE P IICKNIPRLV P GW T KPI C IGRHA F GDQYRATD A V IK GPGK LKLVFV P EGKDE K TELE V 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 170 H NF EEG GGVA MG MYN Q D K SI ED FA HS S FQM A LS K G WPLYLSTKNTILKKYDGRFKDIFQE I Y DK Q Y KS Q FEA QK IWYEHR 249
Cdd:PLN00103 172 Y NF TGA GGVA LS MYN T D E SI RA FA EA S MNT A YQ K K WPLYLSTKNTILKKYDGRFKDIFQE V Y EA Q W KS K FEA AG IWYEHR 251
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 250 LIDDMVA Q A M KSEGG FI WACKNYDGDVQSD SV AQG Y GSLG M MTSVLVCPDGKT V EAEAAHGTVTRHYR MY QKG Q ETSTN P 329
Cdd:PLN00103 252 LIDDMVA Y A L KSEGG YV WACKNYDGDVQSD FL AQG F GSLG L MTSVLVCPDGKT I EAEAAHGTVTRHYR VH QKG G ETSTN S 331
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 330 IASIFAW T RGLAHRAKLD N N KE L AF F ANA LE EVSIE T I E A G F MTKDLA AC I K G l P N V Q R SD YLNT F EF M D KLG E N LK IK L 409
Cdd:PLN00103 332 IASIFAW S RGLAHRAKLD G N AR L LD F TEK LE AACVG T V E S G K MTKDLA LL I H G - P K V S R DQ YLNT E EF I D AVA E E LK AR L 410
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
10-406
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 509.65
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 10 VVEMQ GD ---- E M TR I IW EL I KEKLIFP Y --- VELDLHSY D L G IEN RD A T N D QVTKDA AEAIK KHN VG V K CATI TP DE kr 82
Cdd:COG0538 21 IPFIE GD gigp E I TR A IW KV I DAAVEKA Y ggk RDIEWKEV D A G EKA RD E T G D WLPDET AEAIK EYG VG I K GPLT TP VG -- 98
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 83 veefklk QM W K S P N G TIR N IL GGT V F R EAI - IC K NI P RL V SGWV K - P I I I G R HAYG D Q Y RATDFVVPG P GKVEITYTPS D 160
Cdd:COG0538 99 ------- GG W R S L N V TIR Q IL DLY V C R RPV r YF K GV P SP V KHPE K v D I V I F R ENTE D I Y AGIEWKAGS P EALKLIFFLE D 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 161 GT qkv TYL V HN F E E GG G VAMGMYN q D KSI E DFAHSSF Q M AL SKG - WPLY L ST K NT I L K KYD G R FKD IFQ E IYDKQYKSQ F 239
Cdd:COG0538 172 EM --- GVT V IR F P E DS G IGIKPVS - D EGT E RLVRAAI Q Y AL DNK r KSVT L VH K GN I M K FTE G A FKD WGY E VAEEEFGDK F 247
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 240 ------------- E A Q KI W Y EH R LI DDM VA Q AMKSE G G - FIW A C KN YD GD VQ SD SV A QGY G S LG MMTSVLVCP DG K t V E A 305
Cdd:COG0538 248 itegpwekykgpk P A G KI V Y KD R IA DDM LQ Q ILLRP G E y DVI A T KN LN GD YI SD AL A AQV G G LG IAPGANIGD DG G - A E F 326
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 306 EA A HGT VTRH yrmyqk GQET STNP IAS I FAW T RG L A HR AK L DN nkelaff A NAL E EVSIE TIE A G FM T K DLA ACIK G LP n 385
Cdd:COG0538 327 EA T HGT APKY ------ AGKD STNP GSL I LSG T MM L R HR GW L EA ------- A DLI E KAVEK TIE S G KV T Y DLA RLME G AT - 392
410 420
....*....|....*....|.
gi 28178825 386 vqrsd Y L N T F EF M D KLG ENL K 406
Cdd:COG0538 393 ----- E L S T S EF G D AII ENL D 408
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
11-401
1.33e-86
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 267.24
E-value: 1.33e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 11 VEMQ G D E MTRIIWELI K EK L IFPYV E LDLHSY D L G IENR D A T NDQVTKDAA EA I KK HNVGVKC A TIT P D ---- EK R V E EF 86
Cdd:pfam00180 7 GDGI G P E VMAAALKVL K AA L EKAPL E FEFEER D V G GAAI D E T GEPLPDETL EA C KK ADAVLLG A VGG P K wdpa GV R P E NG 86
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 87 k L KQMW K SP n G TIR N ILGGT VF R e AIICKNIPRLVSGW V K p I I I G R HAY G DQ Y RATDFVVP G P G kveitytpsdgtqkvt 166
Cdd:pfam00180 87 - L LALR K EL - G LFA N LRPAK VF P - PLGDASPLKNEVEG V D - I V I V R ELT G GI Y FGIEKGIK G S G ---------------- 146
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 167 ylvhnfe EGGG V AMGM Y NQ D K s IE DF A HSS F QM A LSK G - WPLYLST K NTI LK KY D g RFKD I FQ E IYDKQ Y K sqfeaq KIW 245
Cdd:pfam00180 147 ------- NEVA V DTKL Y SR D E - IE RI A RVA F EL A RKR G r KKVTSVD K ANV LK SS D - LWRK I VT E VAKAE Y P ------ DVE 211
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 246 Y EH R L I D DMVA Q AM K SEGG F - IWACK N YD GD VQ SD SVAQGY GSLG MMT S VLVCPD G k TVEA E AA HG TVTRHYR myq KG Q e 324
Cdd:pfam00180 212 L EH Q L V D NAAM Q LV K NPSQ F d VIVTP N LF GD IL SD EASMLT GSLG LLP S ASLGAN G - FGIF E PV HG SAPDIAG --- KG I - 286
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 28178825 325 ts T NPIA S I FAWTRG L AHRAK L DNN kelaff A NAL E EVSIETI E A G FM T K DLA A cikglpnvq RSD Y LN T F EF MDKL 401
Cdd:pfam00180 287 -- A NPIA T I LSAAMM L RYSLG L EDA ------ A DKI E AAVLKVL E S G IR T G DLA G --------- SAT Y VS T S EF GEAV 346
PLN00096
PLN00096 isocitrate dehydrogenase (NADP+); Provisional
10-405
2.57e-53
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177715
Cd Length: 393
Bit Score: 182.54
E-value: 2.57e-53
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 10 V V EMQ G D EMTR IIWE LI KE K L I F P Y V ELD - LHSY DL GIE NRD A T N DQV TK D AA EA IKKHNVGV K CA TITP DEKR V EEFK L 88
Cdd:PLN00096 1 M V YVA G E EMTR YTMD LI LA K W I E P H V DTS a WEFF DL RAK NRD D T E DQV LR D VI EA GARLKAIF K EP TITP TADQ V KRLG L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 89 K QM W K SPNG TI R NILG G - T VF R EA I ick N I PRLVS G WV KP IIIG RHA Y G DQ Y R A t DFVVP G P G KVEI T YT P SD G TQKVTY 167
Cdd:PLN00096 81 K KA W G SPNG AM R RGWN G i T IS R DT I --- H I DGVEL G YK KP VFFE RHA V G GE Y S A - GYKIV G K G TLVT T FV P EE G GKPIVV 156
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 168 LVHNFEEGGGVAMGMY N QDKSIEDF A HSS F QMA L SK G WPL Y LS TK N T IL k K YDGR F KD I FQEIY D KQY KS Q F EAQKIWYE 247
Cdd:PLN00096 157 DDRTITDDLNAVVTYH N PLDNVHHL A RIF F GRC L DA G IVP Y VV TK K T VF - K WQEP F WE I MKKVF D EEF KS K F VDKGVMKS 235
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 248 ----- H R L I D dmv A QA MK ---- SE GGF IW A CK NYDGDV QS D SV AQ GYG S L G MM TS V LV CP D GKTV --- E A EA A HGTVT RH 315
Cdd:PLN00096 236 gdelv H L L S D --- A AT MK lvvw TD GGF GM A AH NYDGDV LT D EL AQ VHK S P G FI TS N LV GV D ENGT lik E F EA S HGTVT DM 312
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 28178825 316 YRMYQK G Q ETS T NP IASIFAWTRGLA H R A KLDNN KE LAF - F ANA L EE V SIETIEA G FM T K DL AA cikglpnvqr SDY L N T 394
Cdd:PLN00096 313 DEARLR G E ETS L NP LGMVEGLIGAMN H A A DVHGG KE RVH p F TAK L RA V IHKLFRE G RG T R DL CG ---------- AGG L T T 382
410
....*....|.
gi 28178825 395 FE F M D KLG E N L 405
Cdd:PLN00096 383 EQ F I D AVA E E L 393
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
