NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|42558250|ref|NP_005889|]
View 

caprin-1 isoform 1 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
Caprin-1_C pfam12287
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ...
359-681 2.47e-144

Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.


:

Pssm-ID: 463522 [Multi-domain]  Cd Length: 320  Bit Score: 424.21  E-value: 2.47e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   359 VQDLMAQMQGPYNFIQDSMLDFENQTlDPAIVSAQPmnPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSST 438
Cdd:pfam12287   1 LQDLMAQIQGTYNFMQDSMLDFDKPS-DSAIVSAQP--PSQSPDLSQMVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   439 SEGYTASQPLYQPShaTEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQagtSKPLHSSGINVNAAPFQSMQT 518
Cdd:pfam12287  78 SNACASSGSEYQFH--TSEPPQPEAIDPIQSSMSLPSELAPPSPPLSPASQPQVFQ---SKPASSSGINVNAAPFQSMQT 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   519 VFNMNAPVPPVNEpETLKQQNQYQASYNQSFSSQPHQVEQTEL--QQEQLQTVVGTYHgsPDQSHQVTGNH-QQPPQQNT 595
Cdd:pfam12287 153 VFNVNAPVPPRNE-QELKESSQYSSGYNQSFSSQSTQTVPQCQlpSEQLEQTVVGAYH--PDGTIQVSNGHlAFYPAQTN 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   596 GFPRSNQPYYNSRGVSRGGSRGARGLMNGYRGPaNGFRGGYDGYRPSFSNTPNSGYTQSQFSApRDYSG---YQRDGYQQ 672
Cdd:pfam12287 230 GFPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGP-NGFKGGFDGYRGPFPNTPNGGYGQLQFQA-RDYSGtpySQRDGYQQ 307

                  ....*....
gi 42558250   673 NFKRGSGQS 681
Cdd:pfam12287 308 NYKRGGTQS 316
Caprin-1_dimer pfam18293
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ...
132-247 7.22e-52

Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.


:

Pssm-ID: 436391  Cd Length: 116  Bit Score: 175.09  E-value: 7.22e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   132 RREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHAS 211
Cdd:pfam18293   1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 42558250   212 IHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFD 247
Cdd:pfam18293  81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
 
Name Accession Description Interval E-value
Caprin-1_C pfam12287
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ...
359-681 2.47e-144

Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.


Pssm-ID: 463522 [Multi-domain]  Cd Length: 320  Bit Score: 424.21  E-value: 2.47e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   359 VQDLMAQMQGPYNFIQDSMLDFENQTlDPAIVSAQPmnPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSST 438
Cdd:pfam12287   1 LQDLMAQIQGTYNFMQDSMLDFDKPS-DSAIVSAQP--PSQSPDLSQMVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   439 SEGYTASQPLYQPShaTEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQagtSKPLHSSGINVNAAPFQSMQT 518
Cdd:pfam12287  78 SNACASSGSEYQFH--TSEPPQPEAIDPIQSSMSLPSELAPPSPPLSPASQPQVFQ---SKPASSSGINVNAAPFQSMQT 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   519 VFNMNAPVPPVNEpETLKQQNQYQASYNQSFSSQPHQVEQTEL--QQEQLQTVVGTYHgsPDQSHQVTGNH-QQPPQQNT 595
Cdd:pfam12287 153 VFNVNAPVPPRNE-QELKESSQYSSGYNQSFSSQSTQTVPQCQlpSEQLEQTVVGAYH--PDGTIQVSNGHlAFYPAQTN 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   596 GFPRSNQPYYNSRGVSRGGSRGARGLMNGYRGPaNGFRGGYDGYRPSFSNTPNSGYTQSQFSApRDYSG---YQRDGYQQ 672
Cdd:pfam12287 230 GFPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGP-NGFKGGFDGYRGPFPNTPNGGYGQLQFQA-RDYSGtpySQRDGYQQ 307

                  ....*....
gi 42558250   673 NFKRGSGQS 681
Cdd:pfam12287 308 NYKRGGTQS 316
Caprin-1_dimer pfam18293
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ...
132-247 7.22e-52

Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.


Pssm-ID: 436391  Cd Length: 116  Bit Score: 175.09  E-value: 7.22e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   132 RREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHAS 211
Cdd:pfam18293   1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 42558250   212 IHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFD 247
Cdd:pfam18293  81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
PRK10263 PRK10263
DNA translocase FtsK; Provisional
321-470 1.65e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 48.54  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   321 VEVVNSLQQQPQAASPSVPEPHSLTPVAQADPLVRRQRVQDLMAQM------QGPYNFIQDSMLDFENQTLDPAIVSAQP 394
Cdd:PRK10263  346 VASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVqyneplQQPVQPQQPYYAPAAEQPAQQPYYAPAP 425
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42558250   395 MNPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPlvSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQAT 470
Cdd:PRK10263  426 EQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQT--EQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEET 499
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
327-492 1.15e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.18  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   327 LQQQPQAASPSVPEPHSLTPV--AQADPLVRRQRVQdlmAQMQG-PYNFIQDSMLDFENQTLDPAivsaQPMNPTQnmdM 403
Cdd:TIGR01628 371 LQDQFMQLQPRMRQLPMGSPMggAMGQPPYYGQGPQ---QQFNGqPLGWPRMSMMPTPMGPGGPL----RPNGLAP---M 440
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   404 PQLVCPPVHSESRLAQPNQVPVQpeatqvplvsstsegytasqplYQPSHATEQRPQKEPIDQIQATISLNTDQTTAS-S 482
Cdd:TIGR01628 441 NAVRAPSRNAQNAAQKPPMQPVM----------------------YPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVlA 498
                         170
                  ....*....|
gi 42558250   483 SLPAASQPQV 492
Cdd:TIGR01628 499 SATPQMQKQV 508
 
Name Accession Description Interval E-value
Caprin-1_C pfam12287
Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is ...
359-681 2.47e-144

Cytoplasmic activation/proliferation-associated protein-1 C term; This family of proteins is found in eukaryotes. Proteins in this family are typically between 343 and 708 amino acids in length. This family is the C terminal region of caprin-1. Caprin-1 is a protein involved in regulating cellular proliferation. In mutated phenotypes, the G1 phase of the cell cycle is greatly lengthened, impairing normal proliferation. The C terminal region of caprin-1 contains RGG motifs which are characteriztic of RNA binding domains. It is possible that caprin-1 functions through an RNA binding mechanism.


Pssm-ID: 463522 [Multi-domain]  Cd Length: 320  Bit Score: 424.21  E-value: 2.47e-144
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   359 VQDLMAQMQGPYNFIQDSMLDFENQTlDPAIVSAQPmnPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPLVSST 438
Cdd:pfam12287   1 LQDLMAQIQGTYNFMQDSMLDFDKPS-DSAIVSAQP--PSQSPDLSQMVCPPASPEQRLSQQSDVLQQPEQTQVSPVSPS 77
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   439 SEGYTASQPLYQPShaTEQRPQKEPIDQIQATISLNTDQTTASSSLPAASQPQVFQagtSKPLHSSGINVNAAPFQSMQT 518
Cdd:pfam12287  78 SNACASSGSEYQFH--TSEPPQPEAIDPIQSSMSLPSELAPPSPPLSPASQPQVFQ---SKPASSSGINVNAAPFQSMQT 152
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   519 VFNMNAPVPPVNEpETLKQQNQYQASYNQSFSSQPHQVEQTEL--QQEQLQTVVGTYHgsPDQSHQVTGNH-QQPPQQNT 595
Cdd:pfam12287 153 VFNVNAPVPPRNE-QELKESSQYSSGYNQSFSSQSTQTVPQCQlpSEQLEQTVVGAYH--PDGTIQVSNGHlAFYPAQTN 229
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   596 GFPRSNQPYYNSRGVSRGGSRGARGLMNGYRGPaNGFRGGYDGYRPSFSNTPNSGYTQSQFSApRDYSG---YQRDGYQQ 672
Cdd:pfam12287 230 GFPRPPQPFYNSRGSPRGGPRGGRGLMNGYRGP-NGFKGGFDGYRGPFPNTPNGGYGQLQFQA-RDYSGtpySQRDGYQQ 307

                  ....*....
gi 42558250   673 NFKRGSGQS 681
Cdd:pfam12287 308 NYKRGGTQS 316
Caprin-1_dimer pfam18293
Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a ...
132-247 7.22e-52

Caprin-1 dimerization domain; This domain is found in human Caprin-1 protein. Caprin-1 plays a role in many important biological processes, including cellular proliferation, innate immune response and synaptic plasticity. This domain is found in the highly conserved homologous region 1(HR1) and is responsible for the tight homodimerization of Caprin-1.


Pssm-ID: 436391  Cd Length: 116  Bit Score: 175.09  E-value: 7.22e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   132 RREQLMREEAEQKRLKTVLELQYVLDKLGDDEVRTDLKQGLNGVPILSEEELSLLDEFYKLVDPERDMSLRLNEQYEHAS 211
Cdd:pfam18293   1 KKEAQLKMQAELARLREVLQVQDVLNSLGSEDVRNDFLNGTNGAVKLTEEDLKQLDEFYKLVGPKRDEDTSFADQMQKAA 80
                          90       100       110
                  ....*....|....*....|....*....|....*.
gi 42558250   212 IHLWDLLEGKEKPVCGTTYKVLKEIVERVFQSNYFD 247
Cdd:pfam18293  81 EHLWALLEGKEKPVAGTTYKELKELLDKILNCGYFD 116
PRK10263 PRK10263
DNA translocase FtsK; Provisional
321-470 1.65e-05

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 48.54  E-value: 1.65e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   321 VEVVNSLQQQPQAASPSVPEPHSLTPVAQADPLVRRQRVQDLMAQM------QGPYNFIQDSMLDFENQTLDPAIVSAQP 394
Cdd:PRK10263  346 VASVDVPPAQPTVAWQPVPGPQTGEPVIAPAPEGYPQQSQYAQPAVqyneplQQPVQPQQPYYAPAAEQPAQQPYYAPAP 425
                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 42558250   395 MNPTQNMDMPQLVCPPVHSESRLAQPNQVPVQPEATQVPlvSSTSEGYTASQPLYQPSHATEQRPQKEPIDQIQAT 470
Cdd:PRK10263  426 EQPAQQPYYAPAPEQPVAGNAWQAEEQQSTFAPQSTYQT--EQTYQQPAAQEPLYQQPQPVEQQPVVEPEPVVEET 499
PABP-1234 TIGR01628
polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins ...
327-492 1.15e-04

polyadenylate binding protein, human types 1, 2, 3, 4 family; These eukaryotic proteins recognize the poly-A of mRNA and consists of four tandem RNA recognition domains at the N-terminus (rrm: pfam00076) followed by a PABP-specific domain (pfam00658) at the C-terminus. The protein is involved in the transport of mRNA's from the nucleus to the cytoplasm. There are four paralogs in Homo sapiens which are expressed in testis, platelets, broadly expressed and of unknown tissue range.


Pssm-ID: 130689 [Multi-domain]  Cd Length: 562  Bit Score: 45.18  E-value: 1.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   327 LQQQPQAASPSVPEPHSLTPV--AQADPLVRRQRVQdlmAQMQG-PYNFIQDSMLDFENQTLDPAivsaQPMNPTQnmdM 403
Cdd:TIGR01628 371 LQDQFMQLQPRMRQLPMGSPMggAMGQPPYYGQGPQ---QQFNGqPLGWPRMSMMPTPMGPGGPL----RPNGLAP---M 440
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   404 PQLVCPPVHSESRLAQPNQVPVQpeatqvplvsstsegytasqplYQPSHATEQRPQKEPIDQIQATISLNTDQTTAS-S 482
Cdd:TIGR01628 441 NAVRAPSRNAQNAAQKPPMQPVM----------------------YPPNYQSLPLSQDLPQPQSTASQGGQNKKLAQVlA 498
                         170
                  ....*....|
gi 42558250   483 SLPAASQPQV 492
Cdd:TIGR01628 499 SATPQMQKQV 508
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
329-603 9.56e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.45  E-value: 9.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   329 QQPQAASPSVPePHSLTpvaQADPLVRRQRVQDLMAQMQGpynfiqdsmldfENQTLDPAIVSAQPM-NPTQNMDMPQLV 407
Cdd:pfam03154 216 QPPNQTQSTAA-PHTLI---QQTPTLHPQRLPSPHPPLQP------------MTQPPPPSQVSPQPLpQPSLHGQMPPMP 279
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   408 CP----PVHSESRLA-QPNQVPVQPEATQVPLVSSTSEGYTASQPLYQPSHATEQRPQKEPIDQ--IQATISLNTDQTTA 480
Cdd:pfam03154 280 HSlqtgPSHMQHPVPpQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQplPPAPLSMPHIKPPP 359
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 42558250   481 SSSLPAASQPQVFQagtsKPLHSSG-----INVNAAPFQSMQTVFNMNAPVPPVNEPETLKQQNQYQasynqsfSSQPHQ 555
Cdd:pfam03154 360 TTPIPQLPNPQSHK----HPPHLSGpspfqMNSNLPPPPALKPLSSLSTHHPPSAHPPPLQLMPQSQ-------QLPPPP 428
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*...
gi 42558250   556 VEQTELQQEQLQTVVGTYHGSPDQSHQVTgnhQQPPQQNTGFPRSNQP 603
Cdd:pfam03154 429 AQPPVLTQSQSLPPPAASHPPTSGLHQVP---SQSPFPQHPFVPGGPP 473
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH